DNA Damage

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  Subject Areas on Research

  • 2'-deoxy-5-azacytidine increases binding of cisplatin to DNA by a mechanism independent of DNA hypomethylation. 
  • 5'-3'-UTR interactions regulate p53 mRNA translation and provide a target for modulating p53 induction after DNA damage. 
  • 58-kDa microspherule protein (MSP58) is novel Brahma-related gene 1 (BRG1)-associated protein that modulates p53/p21 senescence pathway. 
  • A 'Semi-Protected Oligonucleotide Recombination' Assay for DNA Mismatch Repair in vivo Suggests Different Modes of Repair for Lagging Strand Mismatches. 
  • A Cross-Cancer Genetic Association Analysis of the DNA Repair and DNA Damage Signaling Pathways for Lung, Ovary, Prostate, Breast, and Colorectal Cancer. 
  • A DNA damage response system associated with the phosphoCTD of elongating RNA polymerase II. 
  • A Multivariate Computational Method to Analyze High-Content RNAi Screening Data. 
  • A PRMT5-RNF168-SMURF2 Axis Controls H2AX Proteostasis. 
  • A Small Molecule Targeting Mutagenic Translesion Synthesis Improves Chemotherapy. 
  • A bacteriophage model system for studying topoisomerase inhibitors. 
  • A colony color method identifies the vulnerability of mitochondria to oxidative damage. 
  • A cut above the other caspases. 
  • A defined human system that supports bidirectional mismatch-provoked excision. 
  • A flucytosine-responsive Mbp1/Swi4-like protein, Mbs1, plays pleiotropic roles in antifungal drug resistance, stress response, and virulence of Cryptococcus neoformans. 
  • A genome-wide RNAi screen reveals multiple regulators of caspase activation. 
  • A histologic study (including DNA quantification and Ki-67 labeling index) in uveal melanomas after brachytherapy with ruthenium plaques. 
  • A hot spot for hydrogen peroxide-induced damage in the human hypoxia-inducible factor 1 binding site of the PGK 1 gene. 
  • A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia. 
  • A methylation-dependent electrostatic switch controls DNA repair and transcriptional activation by E. coli ada. 
  • A modified host-cell reactivation assay to measure repair of alkylating DNA damage for assessing risk of lung adenocarcinoma. 
  • A novel ATM-dependent pathway regulates protein phosphatase 1 in response to DNA damage. 
  • A pleiotropic ATM variant (rs1800057 C>G) is associated with risk of multiple cancers. 
  • A recessive variant of XRCC4 predisposes to non- BRCA1/2 breast cancer in chinese women and impairs the DNA damage response via dysregulated nuclear localization. 
  • A stress response pathway regulates DNA damage through β2-adrenoreceptors and β-arrestin-1. 
  • A topical antioxidant solution containing vitamins C and E stabilized by ferulic acid provides protection for human skin against damage caused by ultraviolet irradiation. 
  • A unique type II topoisomerase mutant that is hypersensitive to a broad range of cleavage-inducing antitumor agents. 
  • AKT1 mediates bypass of the G1/S checkpoint after genotoxic stress in normal human cells. 
  • ALS-associated mutation FUS-R521C causes DNA damage and RNA splicing defects. 
  • ATM activation in normal human tissues and testicular cancer. 
  • ATM regulates a DNA damage response posttranscriptional RNA operon in lymphocytes. 
  • ATM--a key determinant of multiple cellular responses to irradiation. 
  • ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage. 
  • ATM: genome stability, neuronal development, and cancer cross paths. 
  • ATR/ATM-mediated phosphorylation of human Rad17 is required for genotoxic stress responses. 
  • Abasic sites in the transcribed strand of yeast DNA are removed by transcription-coupled nucleotide excision repair. 
  • Accelerated decline in lung function in cigarette smokers is associated with TP53/HDM2 polymorphisms. 
  • Accumulation and DNA damage in fathead minnows (Pimephales promelas) exposed to 2 brominated flame-retardant mixtures, Firemaster 550 and Firemaster BZ-54. 
  • Acetaminophen toxicity in cultured trout liver cells. I. Morphological alterations and effects on cytochrome P450 1A1. 
  • Acquisition of mitochondrial dysregulation and resistance to mitochondrial-mediated apoptosis after genotoxic insult in normal human fibroblasts: a possible model for early stage carcinogenesis. 
  • Activation of the ATM kinase by ionizing radiation and phosphorylation of p53. 
  • Acute DNA damage activates the tumour suppressor p53 to promote radiation-induced lymphoma. 
  • Acute Exposure to Permethrin Modulates Behavioral Functions, Redox, and Bioenergetics Parameters and Induces DNA Damage and Cell Death in Larval Zebrafish. 
  • Aerobic glycolysis suppresses p53 activity to provide selective protection from apoptosis upon loss of growth signals or inhibition of BCR-Abl. 
  • Altered gene expression and DNA damage in peripheral blood cells from Friedreich's ataxia patients: cellular model of pathology. 
  • Amino acid changes in Xrs2p, Dun1p, and Rfa2p that remove the preferred targets of the ATM family of protein kinases do not affect DNA repair or telomere length in Saccharomyces cerevisiae. 
  • An ARF-independent c-MYC-activated tumor suppression pathway mediated by ribosomal protein-Mdm2 Interaction. 
  • An ATM/Chk2-mediated DNA damage-responsive signaling pathway suppresses Epstein-Barr virus transformation of primary human B cells. 
  • An integrative approach identified genes associated with drug response in gastric cancer. 
  • An oxidative stress-based mechanism of doxorubicin cytotoxicity suggests new therapeutic strategies in ABC-DLBCL. 
  • Analysis of DNA damage and repair in nuclear and mitochondrial DNA of animal cells using quantitative PCR. 
  • Analysis of the excision step in human DNA mismatch repair. 
  • Apoptosis leads to photoreceptor degeneration in inherited retinal dystrophy of RCS rats. 
  • Apoptosis: final common pathway of photoreceptor death in rd, rds, and rhodopsin mutant mice. 
  • Arabidopsis SNI1 and RAD51D regulate both gene transcription and DNA recombination during the defense response. 
  • Arrest of replication by mammalian DNA polymerases alpha and beta caused by chromium-DNA lesions. 
  • Association between DNA damage response and repair genes and risk of invasive serous ovarian cancer. 
  • Association between low dietary folate intake and suboptimal cellular DNA repair capacity. 
  • Association between plasma BPDE-Alb adduct concentrations and DNA damage of peripheral blood lymphocytes among coke oven workers. 
  • Association of polymorphisms in AhR, CYP1A1, GSTM1, and GSTT1 genes with levels of DNA damage in peripheral blood lymphocytes among coke-oven workers. 
  • Atm deficiency affects both apoptosis and proliferation to augment Myc-induced lymphomagenesis. 
  • Aven-dependent activation of ATM following DNA damage. 
  • BRCA1 is required for common-fragile-site stability via its G2/M checkpoint function. 
  • BRD4 Prevents R-Loop Formation and Transcription-Replication Conflicts by Ensuring Efficient Transcription Elongation. 
  • Bacterial-induced cell fusion is a danger signal triggering cGAS-STING pathway via micronuclei formation. 
  • Bacteriophage T4, a model system for understanding the mechanism of type II topoisomerase inhibitors. 
  • Base modifications in plasmid DNA caused by potassium permanganate. 
  • Base-specific arrest of in vitro DNA replication by carcinogenic chromium: relationship to DNA interstrand crosslinking. 
  • Bat3 facilitates H3K79 dimethylation by DOT1L and promotes DNA damage-induced 53BP1 foci at G1/G2 cell-cycle phases. 
  • Bayesian Multi-Plate High-Throughput Screening of Compounds. 
  • Bayesian dynamic modeling of latent trait distributions. 
  • Bayesian hierarchically weighted finite mixture models for samples of distributions. 
  • Bi-allelic Variants in TONSL Cause SPONASTRIME Dysplasia and a Spectrum of Skeletal Dysplasia Phenotypes. 
  • Bifunctional DNA alkylator 1,3-bis(2-chloroethyl)-1-nitrosourea activates the ATR-Chk1 pathway independently of the mismatch repair pathway. 
  • Biochemical identification of apoptosis (programmed cell death) in granulosa cells: evidence for a potential mechanism underlying follicular atresia. 
  • Biological Principles of Stereotactic Body Radiation Therapy (SBRT) and Stereotactic Radiation Surgery (SRS): Indirect Cell Death. 
  • Biomarkers of Immune Checkpoint Blockade Response in Triple-Negative Breast Cancer. 
  • CBX4 Regulates Replicative Senescence of WI-38 Fibroblasts. 
  • CHK1 protects oncogenic KRAS-expressing cells from DNA damage and is a target for pancreatic cancer treatment. 
  • Cadmium- and chromium-induced oxidative stress, DNA damage, and apoptotic cell death in cultured human chronic myelogenous leukemic K562 cells, promyelocytic leukemic HL-60 cells, and normal human peripheral blood mononuclear cells. 
  • Caenorhabditis elegans DNA mismatch repair gene msh-2 is required for microsatellite stability and maintenance of genome integrity. 
  • Caenorhabditis elegans generates biologically relevant levels of genotoxic metabolites from aflatoxin B1 but not benzo[a]pyrene in vivo 
  • Caenorhabditis elegans: an emerging model in biomedical and environmental toxicology. 
  • Camptothecin analogues with enhanced antitumor activity at acidic pH. 
  • Can you tBID on it? 
  • Carcinogenic effects of hyperthermia. 
  • Caspase-2-mediated cleavage of Mdm2 creates a p53-induced positive feedback loop. 
  • Cell biology: A BID for the pathway. 
  • Cell cycle control and cancer. 
  • Cell cycle. Checking two steps. 
  • Cell division, growth and death. Cell growth: live and let die. 
  • Cell-cycle checkpoints and cancer. 
  • Cell-extrinsic consequences of epithelial stress: activation of protumorigenic tissue phenotypes. 
  • Cells with pathogenic biallelic mutations in the human MUTYH gene are defective in DNA damage binding and repair. 
  • Characterization of human Gadd45, a p53-regulated protein. 
  • Characterization of the EBV-Induced Persistent DNA Damage Response. 
  • Charting the landscape of tandem BRCT domain-mediated protein interactions. 
  • Checkpoint controls and cancer. Introduction. 
  • Choline deficiency induces apoptosis in SV40-immortalized CWSV-1 rat hepatocytes in culture. 
  • Chromium (VI) activates ataxia telangiectasia mutated (ATM) protein. Requirement of ATM for both apoptosis and recovery from terminal growth arrest. 
  • Chromium genotoxicity: A double-edged sword. 
  • Chromium(III) picolinate produces chromosome damage in Chinese hamster ovary cells. 
  • Chromium(VI) treatment of normal human lung cells results in guanine-specific DNA polymerase arrest, DNA-DNA cross-links and S-phase blockade of cell cycle. 
  • Chromium-induced genotoxicity and apoptosis: relationship to chromium carcinogenesis (review). 
  • Chromosomal translocations in yeast induced by low levels of DNA polymerase a model for chromosome fragile sites. 
  • Chromosome rearrangements and aneuploidy in yeast strains lacking both Tel1p and Mec1p reflect deficiencies in two different mechanisms. 
  • Chronic oxidative DNA damage due to DNA repair defects causes chromosomal instability in Saccharomyces cerevisiae. 
  • Chronic phototoxicity and aggressive squamous cell carcinoma of the skin in children and adults during treatment with voriconazole. 
  • Cisplatin and adriamycin resistance are associated with MutLalpha and mismatch repair deficiency in an ovarian tumor cell line. 
  • Colonic Epithelial-Derived Selenoprotein P Is the Source for Antioxidant-Mediated Protection in Colitis-Associated Cancer. 
  • CometChip enables parallel analysis of multiple DNA repair activities. 
  • Commentary on "Participation of p53 Protein in the Cellular Response to DNA Damage". 
  • Commitment to cell death is signaled by the appearance of a terminin protein of 30 kDa. 
  • Comparative analyses of two primate species diverged by more than 60 million years show different rates but similar distribution of genome-wide UV repair events. 
  • Comparative genome-wide screening identifies a conserved doxorubicin repair network that is diploid specific in Saccharomyces cerevisiae. 
  • Comparative toxicity of silver nanoparticles on oxidative stress and DNA damage in the nematode, Caenorhabditis elegans. 
  • Comparative transcriptome analysis reveals novel roles of the Ras and cyclic AMP signaling pathways in environmental stress response and antifungal drug sensitivity in Cryptococcus neoformans. 
  • Complex response of breast epithelial cell lines to topoisomerase inhibitors. 
  • Complexities of chromium carcinogenesis: role of cellular response, repair and recovery mechanisms. 
  • Compromised CDK1 activity sensitizes BRCA-proficient cancers to PARP inhibition. 
  • Conserved function of Drosophila Fancd2 monoubiquitination in response to double-strand DNA breaks. 
  • Constitutively activated STAT3 frequently coexpresses with epidermal growth factor receptor in high-grade gliomas and targeting STAT3 sensitizes them to Iressa and alkylators. 
  • Control of G1 arrest after DNA damage. 
  • Coordinate regulation of stress- and mitogen-activated protein kinases in the apoptotic actions of ceramide and sphingosine. 
  • Copper ion-mediated modification of bases in DNA in vitro by benzoyl peroxide. 
  • Copper-dependent site-specific mutagenesis by benzoyl peroxide in the supF gene of the mutation reporter plasmid pS189. 
  • Correlation between Charge Transport and Base Excision Repair in the MutY-DNA Glycosylase. 
  • Coupling of human DNA excision repair and the DNA damage checkpoint in a defined in vitro system. 
  • Covalent targeting of remote cysteine residues to develop CDK12 and CDK13 inhibitors. 
  • Critical role of chromium (Cr)-DNA interactions in the formation of Cr-induced polymerase arresting lesions. 
  • Cupric ion/ascorbate/hydrogen peroxide-induced DNA damage: DNA-bound copper ion primarily induces base modifications. 
  • Curing Saccharomyces cerevisiae of the 2 micron plasmid by targeted DNA damage. 
  • Cyclopamine-loaded core-cross-linked polymeric micelles enhance radiation response in pancreatic cancer and pancreatic stellate cells. 
  • DNA Damage Responses during the Cell Cycle: Insights from Model Organisms and Beyond. 
  • DNA adduct formation by 12 chemicals with populations potentially suitable for molecular epidemiological studies. 
  • DNA adducts and exposure to burning oil. 
  • DNA adducts of decarbamoyl mitomycin C efficiently kill cells without wild-type p53 resulting from proteasome-mediated degradation of checkpoint protein 1. 
  • DNA adducts, genetic polymorphisms, and K-ras mutation in human pancreatic cancer. 
  • DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation. 
  • DNA damage and repair in Parkinson's disease: Recent advances and new opportunities. 
  • DNA damage in peripheral blood mononuclear cells correlates with response to biochemotherapy in melanoma. 
  • DNA damage induced by carcinogenic lead chromate particles in cultured mammalian cells. 
  • DNA damage induces phosphorylation of the amino terminus of p53. 
  • DNA damage responses in prokaryotes: regulating gene expression, modulating growth patterns, and manipulating replication forks. 
  • DNA damage responses: mechanisms and roles in human disease: 2007 G.H.A. Clowes Memorial Award Lecture. 
  • DNA damage responses: p53 induction, cell cycle perturbations, and apoptosis. 
  • DNA interstrand crosslinking and strand break repair in human glioma cell lines of varying [1,3-bis(2-chloroethyl)-1-nitrosourea] resistance. 
  • DNA mismatch repair and genetic instability. 
  • DNA mismatch repair: functions and mechanisms. 
  • DNA nicks inflicted by restriction endonucleases are repaired by a RecA- and RecB-dependent pathway in Escherichia coli. 
  • DNA polymerase arrest by adducted trivalent chromium. 
  • DNA polymerase zeta introduces multiple mutations when bypassing spontaneous DNA damage in Saccharomyces cerevisiae. 
  • DNA polymerase zeta is essential for hexavalent chromium-induced mutagenesis. 
  • DNA repair and epidemiology of basal cell carcinoma. 
  • DNA repair capacity for ultraviolet light-induced damage is reduced in peripheral lymphocytes from patients with basal cell carcinoma. 
  • DNA repair capacity in healthy medical students during and after exam stress. 
  • DNA repair mechanisms and the bypass of DNA damage in Saccharomyces cerevisiae. 
  • DNA repair: a double-edged sword. 
  • DNA sequence specificity of doxorubicin-induced mutational damage in uvrB- Escherichia coli. 
  • DNA strand breaks following in vitro exposure to asbestos increase with surface-complexed [Fe3+]. 
  • DNA strand breaks: the DNA template alterations that trigger p53-dependent DNA damage response pathways. 
  • DNA: wire or insulator? 
  • Damage control in broken heart: DNA damage response as a common path in arrhythmogenic cardiomyopathy. 
  • Decline of nucleotide excision repair capacity in aging Caenorhabditis elegans. 
  • Deficiencies in the Fanconi anemia DNA damage response pathway increase sensitivity to HPV-associated head and neck cancer. 
  • Deficient innate immunity, thymopoiesis, and gene expression response to radiation in survivors of childhood acute lymphoblastic leukemia. 
  • Delineating the requirements for spontaneous DNA damage resistance pathways in genome maintenance and viability in Saccharomyces cerevisiae. 
  • Destabilization of simple repetitive DNA sequences by transcription in yeast. 
  • Detecting ultraviolet damage in single DNA molecules by atomic force microscopy. 
  • Detection of DNA damage in transcriptionally active genes by RT-PCR and assessment of repair of cisplatin-induced damage in the glutathione S-transferase-pi gene in human glioblastoma cells. 
  • Development of a cell-based, high-throughput screening assay for ATM kinase inhibitors. 
  • Developmental toxicity and DNA damage from exposure to parking lot runoff retention pond samples in the Japanese medaka (Oryzias latipes). 
  • Dhh1 regulates the G1/S-checkpoint following DNA damage or BRCA1 expression in yeast. 
  • Dietary isothiocyanate-induced apoptosis via thiol modification of DNA topoisomerase IIα. 
  • Differential impact of ionic and coordinate covalent chromium (Cr)-DNA binding on DNA replication. 
  • Disease-associated MRE11 mutants impact ATM/ATR DNA damage signaling by distinct mechanisms. 
  • Disruption of the Rad9/Rad1/Hus1 (9-1-1) complex leads to checkpoint signaling and replication defects. 
  • Dissecting the differences between the alpha and beta anomers of the oxidative DNA lesion FaPydG. 
  • Distinct functional domains of Nbs1 modulate the timing and magnitude of ATM activation after low doses of ionizing radiation. 
  • Distinct functions of Nijmegen breakage syndrome in ataxia telangiectasia mutated-dependent responses to DNA damage. 
  • Distinct functions of POT1 at telomeres. 
  • Distinctive adaptive response to repeated exposure to hydrogen peroxide associated with upregulation of DNA repair genes and cell cycle arrest. 
  • Disulfiram is a direct and potent inhibitor of human O6-methylguanine-DNA methyltransferase (MGMT) in brain tumor cells and mouse brain and markedly increases the alkylating DNA damage. 
  • Double-strand break repair in tandem repeats during bacteriophage T4 infection. 
  • Down-regulation of statin, a nonproliferation-specific nuclear protein, and up-regulation of c-myc after initiation of programmed cell death in mouse fibroblasts. 
  • E3 ubiquitin ligase TRIM32 negatively regulates tumor suppressor p53 to promote tumorigenesis. 
  • ENTPD1 (CD39) Expression Inhibits UVR-Induced DNA Damage Repair through Purinergic Signaling and Is Associated with Metastasis in Human Cutaneous Squamous Cell Carcinoma. 
  • Early-life mitochondrial DNA damage results in lifelong deficits in energy production mediated by redox signaling in Caenorhabditis elegans. 
  • Ecological significance of mitochondrial toxicants. 
  • Effect of mutations in genes affecting homologous recombination on restriction enzyme-mediated and illegitimate recombination in Saccharomyces cerevisiae. 
  • Effective blue light photodynamic therapy does not affect cutaneous langerhans cell number or oxidatively damage DNA. 
  • Effects of 5'-fluoro-2-deoxyuridine on mitochondrial biology in Caenorhabditis elegans. 
  • Effects of camptothecin or TOP1 overexpression on genetic stability in Saccharomyces cerevisiae. 
  • Effects of checkpoint kinase 1 inhibition by prexasertib on the tumor immune microenvironment of head and neck squamous cell carcinoma. 
  • Effects of early life exposure to ultraviolet C radiation on mitochondrial DNA content, transcription, ATP production, and oxygen consumption in developing Caenorhabditis elegans. 
  • Effects of glutathione on chromium-induced DNA crosslinking and DNA polymerase arrest. 
  • Effects of methyl and inorganic mercury exposure on genome homeostasis and mitochondrial function in Caenorhabditis elegans. 
  • Effects of mismatch repair and Hpr1 on transcription-stimulated mitotic recombination in the yeast Saccharomyces cerevisiae. 
  • Effects of reduced mitochondrial DNA content on secondary mitochondrial toxicant exposure in Caenorhabditis elegans. 
  • Endonuclease cleavage of blocked replication forks: An indirect pathway of DNA damage from antitumor drug-topoisomerase complexes. 
  • Endonuclease-independent DNA mismatch repair processes on the lagging strand. 
  • Enhanced repair of a cisplatin-damaged reporter chloramphenicol-O-acetyltransferase gene and altered activities of DNA polymerases alpha and beta, and DNA ligase in cells of a human malignant glioma following in vivo cisplatin therapy. 
  • Enhancer control of local accessibility to V(D)J recombinase. 
  • Epistatic roles for Pseudomonas aeruginosa MutS and DinB (DNA Pol IV) in coping with reactive oxygen species-induced DNA damage. 
  • Error-prone replication of oxidatively damaged DNA by a high-fidelity DNA polymerase. 
  • Etiology of the mutational spectrum of ras genes in human carcinomas. 
  • Experimental models of human carcinogenesis. 
  • Exploiting DNA damage without repair: The activity of platinum chemotherapy in BRCA-mutated prostate cancers. 
  • Exposure to mitochondrial genotoxins and dopaminergic neurodegeneration in Caenorhabditis elegans. 
  • Extending the range of microsecond-to-millisecond chemical exchange detected in labeled and unlabeled nucleic acids by selective carbon R(1rho) NMR spectroscopy. 
  • FANCD2 monoubiquitination and activation by hexavalent chromium [Cr(VI)] exposure: activation is not required for repair of Cr(VI)-induced DSBs. 
  • Fine-structure mapping of meiosis-specific double-strand DNA breaks at a recombination hotspot associated with an insertion of telomeric sequences upstream of the HIS4 locus in yeast. 
  • Fluorescence in situ hybridization method for measuring transfection efficiency. 
  • Folding Landscape of Mutant Huntingtin Exon1: Diffusible Multimers, Oligomers and Fibrils, and No Detectable Monomer. 
  • Formaldehyde-induced mutagenesis in Saccharomyces cerevisiae: molecular properties and the roles of repair and bypass systems. 
  • Formation and repair of 1,3-bis-(2-chloroethyl)-1-nitrosourea and cisplatin induced total genomic DNA interstrand crosslinks in human glioma cells. 
  • Formation of DNA-protein cross-links in cultured mammalian cells upon treatment with iron ions. 
  • Formation of telomeric repeat-containing RNA (TERRA) foci in highly proliferating mouse cerebellar neuronal progenitors and medulloblastoma. 
  • Fragments of ATM which have dominant-negative or complementing activity. 
  • Frameshifts and deletions during in vitro translesion synthesis past Pt-DNA adducts by DNA polymerases beta and eta. 
  • From the Cover: mitotic gene conversion events induced in G1-synchronized yeast cells by gamma rays are similar to spontaneous conversion events. 
  • Functional Interplay between Histone H2B ADP-Ribosylation and Phosphorylation Controls Adipogenesis. 
  • Functional diversity of mammalian type 2C protein phosphatase isoforms: new tales from an old family. 
  • Functions that protect Escherichia coli from DNA-protein crosslinks. 
  • Further evidence for distinct reactive intermediates from nitroxyl and peroxynitrite: effects of buffer composition on the chemistry of Angeli's salt and synthetic peroxynitrite. 
  • GBM radiosensitizers: dead in the water…or just the beginning? 
  • GUCY2C opposes systemic genotoxic tumorigenesis by regulating AKT-dependent intestinal barrier integrity. 
  • Gamma radiation sensitivity and risk of malignant and benign salivary gland tumors: a pilot case-control analysis. 
  • Gamma-radiation sensitivity and risk of glioma. 
  • Gene expression signatures that predict radiation exposure in mice and humans. 
  • Generation of S phase-dependent DNA double-strand breaks by Cr(VI) exposure: involvement of ATM in Cr(VI) induction of gamma-H2AX. 
  • Genetic composition of the Bacillus subtilis SOS system. 
  • Genetic instability and tumorigenesis: introduction. 
  • Genetic susceptibility to benzene-induced toxicity: role of NADPH: quinone oxidoreductase-1. 
  • Genetic susceptibility to lung cancer: the role of DNA damage and repair. 
  • Genetic susceptibility to tobacco carcinogenesis. 
  • Genetic variants in the H2AFX promoter region are associated with risk of sporadic breast cancer in non-Hispanic white women aged  
  • Genome-wide analysis of genomic alterations induced by oxidative DNA damage in yeast. 
  • Genome-wide high-resolution mapping of UV-induced mitotic recombination events in Saccharomyces cerevisiae. 
  • Genomic and Molecular Landscape of DNA Damage Repair Deficiency across The Cancer Genome Atlas. 
  • Genomic instability and endoreduplication triggered by RAD17 deletion. 
  • Genotoxic stress regulates expression of the proto-oncogene Bcl6 in germinal center B cells. 
  • Genotoxicity in Atlantic killifish (Fundulus heteroclitus) from a PAH-contaminated Superfund site on the Elizabeth River, Virginia. 
  • Germline Variants in DNA Damage Repair Genes and HOXB13 Among Black Patients With Early-Onset Prostate Cancer. 
  • Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. 
  • Global analysis of the relationship between the binding of the Bas1p transcription factor and meiosis-specific double-strand DNA breaks in Saccharomyces cerevisiae. 
  • Global mapping of meiotic recombination hotspots and coldspots in the yeast Saccharomyces cerevisiae. 
  • Glutathione regulates susceptibility to oxidant-induced mitochondrial DNA damage in human lymphocytes. 
  • Growth arrest and DNA damage-inducible protein GADD34 assembles a novel signaling complex containing protein phosphatase 1 and inhibitor 1. 
  • Growth arrest and DNA damage-inducible protein GADD34 targets protein phosphatase 1 alpha to the endoplasmic reticulum and promotes dephosphorylation of the alpha subunit of eukaryotic translation initiation factor 2. 
  • HIV-1 Vpr activates the DNA damage response in renal tubule epithelial cells. 
  • HLA-B-associated transcript 3 (Bat3)/Scythe is essential for p300-mediated acetylation of p53. 
  • High incidence of HPV-associated head and neck cancers in FA deficient mice is associated with E7's induction of DNA damage through its inactivation of pocket proteins. 
  • High incidence of female reproductive tract cancers in FA-deficient HPV16-transgenic mice correlates with E7's induction of DNA damage response, an activity mediated by E7's inactivation of pocket proteins. 
  • High-resolution genome-wide analysis of irradiated (UV and γ-rays) diploid yeast cells reveals a high frequency of genomic loss of heterozygosity (LOH) events. 
  • High-resolution mapping of spontaneous mitotic recombination hotspots on the 1.1 Mb arm of yeast chromosome IV. 
  • Histone demethylase AMX-1 is necessary for proper sensitivity to interstrand crosslink DNA damage. 
  • Homologous Recombination and Translesion DNA Synthesis Play Critical Roles on Tolerating DNA Damage Caused by Trace Levels of Hexavalent Chromium. 
  • Human CD34+ hematopoietic progenitors have low, cytokine-unresponsive O6-alkylguanine-DNA alkyltransferase and are sensitive to O6-benzylguanine plus BCNU. 
  • Human Dkk-1, a gene encoding a Wnt antagonist, responds to DNA damage and its overexpression sensitizes brain tumor cells to apoptosis following alkylation damage of DNA. 
  • Human MutSalpha recognizes damaged DNA base pairs containing O6-methylguanine, O4-methylthymine, or the cisplatin-d(GpG) adduct. 
  • Human Rad9 is required for the activation of S-phase checkpoint and the maintenance of chromosomal stability. 
  • Human mitochondrial DNA polymerase gamma exhibits potential for bypass and mutagenesis at UV-induced cyclobutane thymine dimers 
  • Human origin recognition complex large subunit is degraded by ubiquitin-mediated proteolysis after initiation of DNA replication. 
  • Human papillomavirus 16 E6 expression disrupts the p53-mediated cellular response to DNA damage. 
  • Human papillomavirus type 16 E7 oncoprotein causes a delay in repair of DNA damage. 
  • Hypermethylation of growth arrest DNA damage-inducible gene 45 beta promoter in human hepatocellular carcinoma. 
  • Hypo-CpG methylation controls PTEN expression and cell apoptosis in irradiated lung. 
  • INK4a/ARF Expression Impairs Neurogenesis in the Brain of Irradiated Mice. 
  • Identification of JWA as a novel functional gene responsive to environmental oxidative stress induced by benzo[a]pyrene and hydrogen peroxide. 
  • Identification of a DNA Damage-Induced Alternative Splicing Pathway That Regulates p53 and Cellular Senescence Markers. 
  • Identification of a brain- and reproductive-organs-specific gene responsive to DNA damage and retinoic acid. 
  • Identification of a strand-related bias in the PCNA-mediated bypass of spontaneous lesions by yeast Poleta. 
  • Important cellular targets for antimicrobial photodynamic therapy. 
  • In vitro benzo[a]pyrene diol epoxide-induced DNA damage and chromosomal aberrations in primary lymphocytes, smoking, and risk of squamous cell carcinoma of the head and neck. 
  • In vitro evaluation of dimethane sulfonate analogues with potential alkylating activity and selective renal cell carcinoma cytotoxicity. 
  • In vitro expression levels of cell-cycle checkpoint proteins are associated with cellular DNA repair capacity in peripheral blood lymphocytes: a multivariate analysis. 
  • In vitro repair synthesis of BCNU-induced DNA damage. 
  • In vivo mutagenesis of the reporter plasmid pSP189 induced by exposure of host Ad293 cells to activated polymorphonuclear leukocytes. 
  • In vivo repair of alkylating and oxidative DNA damage in the mitochondrial and nuclear genomes of wild-type and glycosylase-deficient Caenorhabditis elegans 
  • Incision of trivalent chromium [Cr(III)]-induced DNA damage by Bacillus caldotenax UvrABC endonuclease. 
  • Increased expression of senescence markers in cystic fibrosis airways. 
  • Induction of apoptotic cell death by particulate lead chromate: differential effects of vitamins C and E on genotoxicity and survival. 
  • Induction of internucleosomal DNA fragmentation by carcinogenic chromate: relationship to DNA damage, genotoxicity, and inhibition of macromolecular synthesis. 
  • Induction of oxidative cell damage by photo-treatment with zinc meta N-methylpyridylporphyrin. 
  • Inhibition of lead chromate clastogenesis by ascorbate: relationship to particle dissolution and uptake. 
  • Inhibition of the p53 E3 ligase HDM-2 induces apoptosis and DNA damage--independent p53 phosphorylation in mantle cell lymphoma. 
  • Initiating cellular stress responses. 
  • Innate immune signaling drives late cardiac toxicity following DNA-damaging cancer therapies. 
  • Inner nuclear envelope proteins SUN1 and SUN2 play a prominent role in the DNA damage response. 
  • Interaction of FANCD2 and NBS1 in the DNA damage response. 
  • Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigen. 
  • Interactions between p53 and MDM2 in a mammalian cell cycle checkpoint pathway. 
  • Interactions of nucleolin and ribosomal protein L26 (RPL26) in translational control of human p53 mRNA. 
  • Interlaboratory validation of a new assay for DNA-protein crosslinks. 
  • Internalization of carcinogenic lead chromate particles by cultured normal human lung epithelial cells: formation of intracellular lead-inclusion bodies and induction of apoptosis. 
  • Interplay between DNA tumor viruses and the host DNA damage response. 
  • Involvement of autophagy and mitochondrial dynamics in determining the fate and effects of irreparable mitochondrial DNA damage. 
  • Involvement of the MKK6-p38gamma cascade in gamma-radiation-induced cell cycle arrest. 
  • Involvement of the cohesin protein, Smc1, in Atm-dependent and independent responses to DNA damage. 
  • Involvement of two endonuclease III homologs in the base excision repair pathway for the processing of DNA alkylation damage in Saccharomyces cerevisiae. 
  • Ionizing radiation activates the ATM kinase throughout the cell cycle. 
  • Ionizing radiation-induced DNA damage, response, and repair. 
  • Isogenic normal basal and luminal mammary epithelial isolated by a novel method show a differential response to ionizing radiation. 
  • Isolation of SOS constitutive mutants of Escherichia coli. 
  • Isolation of an hMSH2-p160 heterodimer that restores DNA mismatch repair to tumor cells. 
  • Joint effects of single nucleotide polymorphisms in P53BP1 and p53 on breast cancer risk in a Chinese population. 
  • Jumping at the chance for precise DNA integration. 
  • KIND1 Loss Sensitizes Keratinocytes to UV-Induced Inflammatory Response and DNA Damage. 
  • Klotho, an antiaging molecule, attenuates oxidant-induced alveolar epithelial cell mtDNA damage and apoptosis. 
  • LKB1 reduces ROS-mediated cell damage via activation of p38. 
  • LRRK2 G2019S-induced mitochondrial DNA damage is LRRK2 kinase dependent and inhibition restores mtDNA integrity in Parkinson's disease. 
  • LRRK2 mutations cause mitochondrial DNA damage in iPSC-derived neural cells from Parkinson's disease patients: reversal by gene correction. 
  • Localization of an aminoacridine antitumor agent in a type II topoisomerase-DNA complex. 
  • Loss of ARID1A in Tumor Cells Renders Selective Vulnerability to Combined Ionizing Radiation and PARP Inhibitor Therapy. 
  • Loss of a histone deacetylase dramatically alters the genomic distribution of Spo11p-catalyzed DNA breaks in Saccharomyces cerevisiae. 
  • Loss of a p53-associated G1 checkpoint does not decrease cell survival following DNA damage. 
  • Low-Dose Irradiation Enhances Gene Targeting in Human Pluripotent Stem Cells. 
  • Luminal alkalinization attenuates proteinuria-induced oxidative damage in proximal tubular cells. 
  • MDM2-HDAC1-mediated deacetylation of p53 is required for its degradation. 
  • MYC paralog-dependent apoptotic priming orchestrates a spectrum of vulnerabilities in small cell lung cancer. 
  • Mapping of copper/hydrogen peroxide-induced DNA damage at nucleotide resolution in human genomic DNA by ligation-mediated polymerase chain reaction. 
  • Mapping of peroxyl radical induced damage on genomic DNA. 
  • Mapping oxidative DNA damage and mechanisms of repair. 
  • Mapping oxidative DNA damage at nucleotide level. 
  • Mapping oxidative DNA damage using ligation-mediated polymerase chain reaction technology. 
  • Mathematical modeling: epidemiology meets systems biology. 
  • Measurement of oxidative DNA damage in the human p53 and PGK1 gene at nucleotide resolution. 
  • Mechanism of the anti-tumour effect of biochemotherapy in melanoma: preliminary results. 
  • Mechanisms in eukaryotic mismatch repair. 
  • Mechanistic insights into the cytotoxicity and genotoxicity induced by glycidamide in human mammary cells. 
  • Metabolic stress is a barrier to Epstein-Barr virus-mediated B-cell immortalization. 
  • Metal ion-dependent hydrogen peroxide-induced DNA damage is more sequence specific than metal specific. 
  • Methylation of histone H4 lysine 20 by PR-Set7 ensures the integrity of late replicating sequence domains in Drosophila. 
  • Mismatch repair and nucleotide excision repair proteins cooperate in the recognition of DNA interstrand crosslinks. 
  • Mismatch repair, genetic stability, and cancer. 
  • Mitochondria as a target of environmental toxicants 
  • Mitochondria as a target of organophosphate and carbamate pesticides: Revisiting common mechanisms of action with new approach methodologies. 
  • Mitochondria in lung biology and pathology: more than just a powerhouse. 
  • Mitochondria, energetics, epigenetics, and cellular responses to stress. 
  • Mitochondrial DNA Mutagenesis: Feature of and Biomarker for Environmental Exposures and Aging. 
  • Mitochondrial DNA damage as a peripheral biomarker for mitochondrial toxin exposure in rats. 
  • Mitochondrial DNA damage as a potential biomarker of LRRK2 kinase activity in LRRK2 Parkinson's disease. 
  • Mitochondrial DNA damage induced autophagy, cell death, and disease. 
  • Mitochondrial DNA damage: molecular marker of vulnerable nigral neurons in Parkinson's disease. 
  • Mitochondrial DNA-depleted A549 cells are resistant to bleomycin. 
  • Mitochondrial dynamics and autophagy aid in removal of persistent mitochondrial DNA damage in Caenorhabditis elegans 
  • Mitochondrial fusion, fission, and mitochondrial toxicity. 
  • Mitochondrial hTERT exacerbates free-radical-mediated mtDNA damage. 
  • Mitochondrial localization of telomerase as a determinant for hydrogen peroxide-induced mitochondrial DNA damage and apoptosis. 
  • Mitochondrial toxicity in hearts of CD-1 mice following perinatal exposure to AZT, 3TC, or AZT/3TC in combination. 
  • Mitogen-induced B-cell proliferation activates Chk2-dependent G1/S cell cycle arrest. 
  • Modeling folate, one-carbon metabolism, and DNA methylation. 
  • Molecular biology of esophageal cancer. 
  • Molecular cross-talk among chromosome fragility syndromes. 
  • Mouse embryonic stem cells carrying one or two defective Msh2 alleles respond abnormally to oxidative stress inflicted by low-level radiation. 
  • Multiple roles of ATM in monitoring and maintaining DNA integrity. 
  • Multiplication of the SNCA locus exacerbates neuronal nuclear aging. 
  • Mutagen sensitivity in upper aerodigestive tract cancer: a case-control analysis. 
  • Mutagenic effects of abasic and oxidized abasic lesions in Saccharomyces cerevisiae. 
  • Mutation of potassium permanganate- and hydrogen peroxide-treated plasmid pZ189 replicating in CV-1 monkey kidney cells. 
  • Mutational fingerprints of aging. 
  • Mycobacterial Mutagenesis and Drug Resistance Are Controlled by Phosphorylation- and Cardiolipin-Mediated Inhibition of the RecA Coprotease. 
  • NAD+ modulates p53 DNA binding specificity and function. 
  • Nanomechanical fingerprints of UV damage to DNA. 
  • Nanomechanical fingerprints of gamma radiation damage to DNA. 
  • Nanoscale detection of ionizing radiation damage to DNA by atomic force microscopy. 
  • Network calisthenics: control of E2F dynamics in cell cycle entry. 
  • Neuropathology in respiratory-related motoneurons in young Pompe (Gaa(-/-)) mice. 
  • New Insights into the Post-Translational Regulation of DNA Damage Response and Double-Strand Break Repair in Caenorhabditis elegans. 
  • Newly Revised Quantitative PCR-Based Assay for Mitochondrial and Nuclear DNA Damage. 
  • Nitric oxide synthase-2 induction optimizes cardiac mitochondrial biogenesis after endotoxemia. 
  • Non-canonical roles of apoptotic and DNA double-strand break repair factors in mediating cellular response to ionizing radiation. 
  • Noncanonical agonist PPARγ ligands modulate the response to DNA damage and sensitize cancer cells to cytotoxic chemotherapy. 
  • Nonselective autophagy reduces mitochondrial content during starvation in Caenorhabditis elegans. 
  • Norfloxacin-induced DNA gyrase cleavage complexes block Escherichia coli replication forks, causing double-stranded breaks in vivo. 
  • Nrf2 inactivation enhances placental angiogenesis in a preeclampsia mouse model and improves maternal and fetal outcomes. 
  • Nuclear basic fibroblast growth factor regulates triple-negative breast cancer chemo-resistance. 
  • Nucleolar organization, ribosomal DNA array stability, and acrocentric chromosome integrity are linked to telomere function. 
  • Nucleolar-nucleoplasmic shuttling of TARG1 and its control by DNA damage-induced poly-ADP-ribosylation and by nucleolar transcription. 
  • Nucleotide excision repair functions in the removal of chromium-induced DNA damage in mammalian cells. 
  • On the TRAIL from p53 to apoptosis? 
  • Our cells get stressed too! Implications for human disease. 
  • Overexpressed heat shock protein 70 protects cells against DNA damage caused by ultraviolet C in a dose-dependent manner. 
  • Overexpression of hMTH in peripheral lymphocytes and risk of prostate cancer: a case-control analysis. 
  • Overlapping specificities of base excision repair, nucleotide excision repair, recombination, and translesion synthesis pathways for DNA base damage in Saccharomyces cerevisiae. 
  • Oxidants, antioxidants and the ischemic brain. 
  • Oxidative DNA base damage in MCF-10A breast epithelial cells at clinically achievable concentrations of doxorubicin. 
  • Oxidative DNA damage and DNA repair enzyme expression are inversely related in murine models of fatty liver disease. 
  • Oxidative DNA damage during night shift work. 
  • Oxidative DNA damage during sleep periods among nightshift workers. 
  • Oxidative damage is a potential cause of cone cell death in retinitis pigmentosa. 
  • Oxidative damage to macromolecules in human Parkinson disease and the rotenone model. 
  • P53, cell cycle control and apoptosis: implications for cancer. 
  • P53: a determinant of the cell cycle response to DNA damage. 
  • PCR-Based Analysis of Mitochondrial DNA Copy Number, Mitochondrial DNA Damage, and Nuclear DNA Damage. 
  • PM2.5 constituents and oxidative DNA damage in humans. 
  • PPM1D mutations are oncogenic drivers of de novo diffuse midline glioma formation. 
  • PRDX6 attenuates oxidative stress- and TGFbeta-induced abnormalities of human trabecular meshwork cells. 
  • Paradoxical effects of a stress signal on pro- and anti-apoptotic machinery in HTLV-1 Tax expressing cells. 
  • Participation of ATM, SMG1, and DDX5 in a DNA Damage-Induced Alternative Splicing Pathway. 
  • Participation of p53 protein in the cellular response to DNA damage. 
  • Peroxynitrite formation and decreased catalase activity in autoimmune MRL-lpr/lpr mice. 
  • Persistence of a regeneration-associated, transitional alveolar epithelial cell state in pulmonary fibrosis. 
  • Persistent DNA damage signaling and DNA polymerase theta promote broken chromosome segregation. 
  • Persistent genetic instability in cancer cells induced by non-DNA-damaging stress exposures. 
  • Personal exposure to particulate PAHs and anthraquinone and oxidative DNA damages in humans. 
  • Pharmacologic Tumor PDL1 Depletion with Cefepime or Ceftazidime Promotes DNA Damage and Sensitivity to DNA-Damaging Agents. 
  • Pharmacologic inhibition of ataxia telangiectasia and Rad3-related (ATR) in the treatment of head and neck squamous cell carcinoma. 
  • Pharmacological blockade of a β(2)AR-β-arrestin-1 signaling cascade prevents the accumulation of DNA damage in a behavioral stress model. 
  • Phosphatases join kinases in DNA-damage response pathways. 
  • Phosphorylation of SMC1 is a critical downstream event in the ATM-NBS1-BRCA1 pathway. 
  • Phosphorylation of serine 1387 in Brca1 is specifically required for the Atm-mediated S-phase checkpoint after ionizing irradiation. 
  • Post-transcriptional RNA regulons affecting cell cycle and proliferation. 
  • Postlipopolysaccharide oxidative damage of mitochondrial DNA. 
  • Predictors of mitochondrial DNA copy number and damage in a mercury-exposed rural Peruvian population near artisanal and small-scale gold mining: An exploratory study. 
  • Programmed cell death induced by ceramide. 
  • Prospective analysis of DNA damage and repair markers of lung cancer risk from the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial. 
  • Protein phosphatase 2A-dependent dephosphorylation of replication protein A is required for the repair of DNA breaks induced by replication stress. 
  • Protein phosphatase 5 is required for ATR-mediated checkpoint activation. 
  • Protein tyrosine phosphatase (PTP) inhibition enhances chromosomal stability after genotoxic stress: decreased chromosomal instability (CIN) at the expense of enhanced genomic instability (GIN)? 
  • Proteolysis of Rad17 by Cdh1/APC regulates checkpoint termination and recovery from genotoxic stress. 
  • Pulmonary toxicity after exposure to military-relevant heavy metal tungsten alloy particles. 
  • QPCR: a tool for analysis of mitochondrial and nuclear DNA damage in ecotoxicology. 
  • Quantitative PCR-based measurement of nuclear and mitochondrial DNA damage and repair in mammalian cells. 
  • Quantitative PCR-based measurement of nuclear and mitochondrial DNA damage and repair in mammalian cells. 
  • Quenching of DNA cross-link precursors of chloroethylnitrosoureas and attenuation of DNA interstrand cross-linking by glutathione. 
  • REV1 inhibitor JH-RE-06 enhances tumor cell response to chemotherapy by triggering senescence hallmarks. 
  • Rad18 confers hematopoietic progenitor cell DNA damage tolerance independently of the Fanconi Anemia pathway in vivo. 
  • Radiation-induced genomic instability: radiation quality and dose response. 
  • Rapid assessment of repair of ultraviolet DNA damage with a modified host-cell reactivation assay using a luciferase reporter gene and correlation with polymorphisms of DNA repair genes in normal human lymphocytes. 
  • Rapid mtDNA deletion by oxidants in rat liver mitochondria after hemin exposure. 
  • Reaction mechanism of human DNA repair excision nuclease. 
  • Reactive nitrogen and oxygen species in interleukin-1-mediated DNA damage associated with osteoarthritis. 
  • Real-Time Genomic Profiling of Pancreatic Ductal Adenocarcinoma: Potential Actionability and Correlation with Clinical Phenotype. 
  • Recognition and repair of compound DNA lesions (base damage and mismatch) by human mismatch repair and excision repair systems. 
  • Recombinant adenovirus vector expressing wild-type p53 is a potent inhibitor of prostate cancer cell proliferation. 
  • Recombination between homologous chromosomes induced by unrepaired UV-generated DNA damage requires Mus81p and is suppressed by Mms2p. 
  • Recombination-dependent DNA replication stimulated by double-strand breaks in bacteriophage T4. 
  • Recurrent mutations in topoisomerase IIα cause a previously undescribed mutator phenotype in human cancers. 
  • Reduced DNA repair capacity in lung cancer patients. 
  • Reduced DNA repair of benzo[a]pyrene diol epoxide-induced adducts and common XPD polymorphisms in breast cancer patients. 
  • Reduced levels of DNA polymerase delta induce chromosome fragile site instability in yeast. 
  • Regulation of p53 by hypoxia: dissociation of transcriptional repression and apoptosis from p53-dependent transactivation. 
  • Regulation of p53 translation and induction after DNA damage by ribosomal protein L26 and nucleolin. 
  • Relationship between lifetime ovulatory cycles and overexpression of mutant p53 in epithelial ovarian cancer. 
  • Repair capacity for UV light induced DNA damage associated with risk of nonmelanoma skin cancer and tumor progression. 
  • Repair of UV light-induced DNA damage and risk of cutaneous malignant melanoma. 
  • Repair of large insertion/deletion heterologies in human nuclear extracts is directed by a 5' single-strand break and is independent of the mismatch repair system. 
  • Repair of mitomycin C cross-linked DNA in mammalian cells measured by a host cell reactivation assay. 
  • Repair of the Escherichia coli chromosome after in vivo scission by the EcoRI endonuclease. 
  • Repair of topoisomerase-mediated DNA damage in bacteriophage T4. 
  • Requirement of protein phosphatase 5 in DNA-damage-induced ATM activation. 
  • Rev7 loss alters cisplatin response and increases drug efficacy in chemotherapy-resistant lung cancer. 
  • Role for topoisomerase 1 in transcription-associated mutagenesis in yeast. 
  • Role of mitochondrial DNA damage and dysfunction in veterans with Gulf War Illness. 
  • Rsp5 ubiquitin-protein ligase mediates DNA damage-induced degradation of the large subunit of RNA polymerase II in Saccharomyces cerevisiae. 
  • SARS-CoV-2 triggers DNA damage response in Vero E6 cells. 
  • SET8 Inhibition Potentiates Radiotherapy by Suppressing DNA Damage Repair in Carcinomas. 
  • SOS induction as an in vivo assay of enzyme-DNA interactions. 
  • Saccharomyces cerevisiae Ntg1p and Ntg2p: broad specificity N-glycosylases for the repair of oxidative DNA damage in the nucleus and mitochondria. 
  • Salicylic acid activates DNA damage responses to potentiate plant immunity. 
  • Self-inflicted DNA double-strand breaks sustain tumorigenicity and stemness of cancer cells. 
  • Sensitivity to DNA damage induced by benzo(a)pyrene diol epoxide and risk of lung cancer: a case-control analysis. 
  • Separate pathways for p53 induction by ionizing radiation and N-(phosphonoacetyl)-L-aspartate. 
  • Shared genetic pathways contribute to the tolerance of endogenous and low-dose exogenous DNA damage in yeast. 
  • Single-cell microarray enables high-throughput evaluation of DNA double-strand breaks and DNA repair inhibitors. 
  • Single-nucleotide polymorphisms of DNA damage response genes are associated with overall survival in patients with pancreatic cancer. 
  • Site-specific methylases induce the SOS DNA repair response in Escherichia coli. 
  • Spatial organization of the mammalian genome surveillance machinery in response to DNA strand breaks. 
  • Specific chemopreventive agents trigger proteasomal degradation of G1 cyclins: implications for combination therapy. 
  • Stoichiometric preference in copper-promoted oxidative DNA damage by ochratoxin A. 
  • Strategic Therapeutic Targeting to Overcome Venetoclax Resistance in Aggressive B-cell Lymphomas. 
  • Stress and death: breaking up the c-Abl/14-3-3 complex in apoptosis. 
  • Structural and Functional Analysis of the GADD34:PP1 eIF2α Phosphatase. 
  • Structural basis of Rev1-mediated assembly of a quaternary vertebrate translesion polymerase complex consisting of Rev1, heterodimeric polymerase (Pol) ζ, and Pol κ. 
  • Substrate spectrum of human excinuclease: repair of abasic sites, methylated bases, mismatches, and bulky adducts. 
  • Suppression of CHK1 by ETS Family Members Promotes DNA Damage Response Bypass and Tumorigenesis. 
  • Suppression of isoprenylcysteine carboxylmethyltransferase compromises DNA damage repair. 
  • Supraspinal inactivation of mitochondrial superoxide dismutase is a source of peroxynitrite in the development of morphine antinociceptive tolerance. 
  • Survival and DNA damage in Chinese hamster V79 cells exposed to alpha particles emitted by DNA-incorporated astatine-211. 
  • Tagging SNPs in non-homologous end-joining pathway genes and risk of glioma. 
  • Tagging single nucleotide polymorphisms in phosphoinositide-3-kinase-related protein kinase genes involved in DNA damage "checkpoints" and lung cancer susceptibility. 
  • Targeted ubiquitination of CDT1 by the DDB1-CUL4A-ROC1 ligase in response to DNA damage. 
  • Targeting nucleolin for better survival in diffuse large B-cell lymphoma. 
  • Targeting the ATM Kinase to Enhance the Efficacy of Radiotherapy and Outcomes for Cancer Patients. 
  • Telomere shortening in cultured autografts of patients with burns. 
  • Temperature-sensitive mutants of the EcoRI endonuclease. 
  • Testicular germ-cell apoptosis in stressed rats following combined exposure to pyridostigmine bromide, N,N-diethyl m-toluamide (DEET), and permethrin. 
  • The 9-1-1 checkpoint clamp physically interacts with polzeta and is partially required for spontaneous polzeta-dependent mutagenesis in Saccharomyces cerevisiae. 
  • The ATM-dependent DNA damage signaling pathway. 
  • The Abl family kinases: mechanisms of regulation and signaling. 
  • The DNA binding domain of a papillomavirus E2 protein programs a chimeric nuclease to cleave integrated human papillomavirus DNA in HeLa cervical carcinoma cells. 
  • The DNA damage response in viral-induced cellular transformation. 
  • The DNA damage response: implications for tumor responses to radiation and chemotherapy. 
  • The DNA damage- and transcription-associated protein paxip1 controls thymocyte development and emigration. 
  • The DNA helicase activities of Rad3 protein of Saccharomyces cerevisiae and helicase II of Escherichia coli are differentially inhibited by covalent and noncovalent DNA modifications. 
  • The N2-ethylguanine and the O6-ethyl- and O6-methylguanine lesions in DNA: contrasting responses from the "bypass" DNA polymerase eta and the replicative DNA polymerase alpha. 
  • The QPCR assay for analysis of mitochondrial DNA damage, repair, and relative copy number. 
  • The Rad50S allele promotes ATM-dependent DNA damage responses and suppresses ATM deficiency: implications for the Mre11 complex as a DNA damage sensor. 
  • The Trim39 ubiquitin ligase inhibits APC/CCdh1-mediated degradation of the Bax activator MOAP-1. 
  • The adenovirus E4orf6 protein inhibits DNA double strand break repair and radiosensitizes human tumor cells in an E1B-55K-independent manner. 
  • The antioxidant, MnTE-2-PyP, prevents side-effects incurred by prostate cancer irradiation. 
  • The bromodomain protein Brd4 insulates chromatin from DNA damage signalling. 
  • The compact chromatin structure of a Ty repeated sequence suppresses recombination hotspot activity in Saccharomyces cerevisiae. 
  • The dCMP transferase activity of yeast Rev1 is biologically relevant during the bypass of endogenously generated AP sites. 
  • The effect of oxidative metabolism on spontaneous Pol zeta-dependent translesion synthesis in Saccharomyces cerevisiae. 
  • The effect of sequence context on spontaneous Polzeta-dependent mutagenesis in Saccharomyces cerevisiae. 
  • The human oncoprotein and chromatin architectural factor DEK counteracts DNA replication stress. 
  • The long amplicon quantitative PCR for DNA damage assay as a sensitive method of assessing DNA damage in the environmental model, Atlantic killifish (Fundulus heteroclitus). 
  • The mammalian Rad24 homologous to yeast Saccharomyces cerevisiae Rad24 and Schizosaccharomyces pombe Rad17 is involved in DNA damage checkpoint. 
  • The many substrates and functions of ATM. 
  • The mechanism of nucleotide excision repair-mediated UV-induced mutagenesis in nonproliferating cells. 
  • The multifaceted roles of nitric oxide in cancer. 
  • The oncoprotein DEK affects the outcome of PARP1/2 inhibition during mild replication stress. 
  • The other function of DNA photolyase: stimulation of excision repair of chemical damage to DNA. 
  • The p53 Transactivation Domain 1-Dependent Response to Acute DNA Damage in Endothelial Cells Protects against Radiation-Induced Cardiac Injury. 
  • The p53 signal transduction pathway is intact in human neuroblastoma despite cytoplasmic localization. 
  • The p53-dependent G1 cell cycle checkpoint pathway and ataxia-telangiectasia. 
  • The p53-dependent gamma-ray response of GADD45. 
  • The phage T4 protein UvsW drives Holliday junction branch migration. 
  • The production and characterization of murine monoclonal antibodies to human Gadd45 raised against a recombinant protein. 
  • The risks and benefits of long-term use of hydroxyurea in sickle cell anemia: A 17.5 year follow-up. 
  • The role of Dbf4-dependent protein kinase in DNA polymerase ζ-dependent mutagenesis in Saccharomyces cerevisiae. 
  • The role of Exo1p exonuclease in DNA end resection to generate gene conversion tracts in Saccharomyces cerevisiae. 
  • The role of p53 in cell-cycle control and apoptosis: implications for cancer. 
  • The role of the c-Jun N-terminal kinases 1/2 and receptor-interacting protein kinase 3 in furosemide-induced liver injury. 
  • The specificity of topoisomerase-mediated DNA cleavage defines acridine-induced frameshift specificity within a hotspot in bacteriophage T4. 
  • The synthesis and anti-neoplastic activity of N2-isobutyryl-2'-deoxyguanosine-N7-cyanoborane derivatives. 
  • The telomeric protein TRF2 binds the ATM kinase and can inhibit the ATM-dependent DNA damage response. 
  • The tight linkage between DNA replication and double-strand break repair in bacteriophage T4. 
  • The tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) induces mitochondrial and nuclear DNA damage in Caenorhabditis elegans. 
  • The uric acid transporter SLC2A9 is a direct target gene of the tumor suppressor p53 contributing to antioxidant defense. 
  • Three-state kinetic mechanism for scaffold-mediated signal transduction. 
  • Thresholds for thermal damage to normal tissues: an update. 
  • Thymic model for examining BRCA2 expression and function. 
  • Tirapazamine: a hypoxia-activated topoisomerase II poison. 
  • Tissue- and strain-specific effects of a genotoxic carcinogen 1,3-butadiene on chromatin and transcription. 
  • Tn5-mediated bleomycin resistance in Escherichia coli requires the expression of host genes. 
  • Toll-like receptor 4 mediates mitochondrial DNA damage and biogenic responses after heat-inactivated E. coli. 
  • Towards precision prevention: Technologies for identifying healthy individuals with high risk of disease. 
  • Transcription-associated mutagenesis. 
  • Transcriptional control of glyoxalase 1 by Nrf2 provides a stress-responsive defence against dicarbonyl glycation. 
  • Transcriptional inhibition by carcinogenic chromate: relationship to DNA damage. 
  • Transient inhibition of ATM kinase is sufficient to enhance cellular sensitivity to ionizing radiation. 
  • Truncating variants in p53AIP1 disrupting DNA damage-induced apoptosis are associated with prostate cancer risk. 
  • Tumor Repression of VCaP Xenografts by a Pyrrole-Imidazole Polyamide. 
  • Tumor necrosis factor-alpha is a potent endogenous mutagen that promotes cellular transformation. 
  • Two types of recombination hotspots in bacteriophage T4: one requires DNA damage and a replication origin and the other does not. 
  • UV disinfection of adenoviruses: molecular indications of DNA damage efficiency. 
  • UVA generates pyrimidine dimers in DNA directly. 
  • UVC-induced mitochondrial degradation via autophagy correlates with mtDNA damage removal in primary human fibroblasts. 
  • Ubiquitination of the DNA-damage checkpoint kinase CHK1 by TRAF4 is required for CHK1 activation. 
  • Unconventional ubiquitin recognition by the ubiquitin-binding motif within the Y family DNA polymerases iota and Rev1. 
  • Urinary biomarkers of oxidative status. 
  • Variation in DNA-Damage Responses to an Inhalational Carcinogen (1,3-Butadiene) in Relation to Strain-Specific Differences in Chromatin Accessibility and Gene Transcription Profiles in C57BL/6J and CAST/EiJ Mice. 
  • WAF1/CIP1 is induced in p53-mediated G1 arrest and apoptosis. 
  • When the checkpoints have gone: insights into Cdc25 functional activation. 
  • Whole thorax irradiation of non-human primates induces persistent nuclear damage and gene expression changes in peripheral blood cells. 
  • Widespread activation of the DNA damage response in human pancreatic intraepithelial neoplasia. 
  • Wild-type p53 is a cell cycle checkpoint determinant following irradiation. 
  • Wnt Signaling and Drug Resistance in Cancer. 
  • Yeast base excision repair: interconnections and networks. 
  • Yeast screens identify the RNA polymerase II CTD and SPT5 as relevant targets of BRCA1 interaction. 
  • ZTF-8 interacts with the 9-1-1 complex and is required for DNA damage response and double-strand break repair in the C. elegans germline. 
  • hMutSalpha- and hMutLalpha-dependent phosphorylation of p53 in response to DNA methylator damage. 
  • p53 and ATM: cell cycle, cell death, and cancer. 
  • p53 functional impairment and high p21waf1/cip1 expression in human T-cell lymphotropic/leukemia virus type I-transformed T cells. 
  • p53 regulates the expression of the tumor suppressor gene maspin. 
  • p53-dependent G1 arrest involves pRB-related proteins and is disrupted by the human papillomavirus 16 E7 oncoprotein. 
  • ssDNA is an allosteric regulator of the C. crescentus SOS-independent DNA damage response transcription activator, DriD. 
  • βarrestin-1 regulates DNA repair by acting as an E3-ubiquitin ligase adaptor for 53BP1. 
• 

  Keywords of People

  • Berchuck, Andrew, James M. Ingram Distinguished Professor of Gynecologic Oncology, Obstetrics and Gynecology, Gynecologic Oncology
  • Clyde, Merlise, Professor of Statistical Science, Statistical Science
  • Floyd, Scott Richard, Gary Hock and Lyn Proctor Associate Professor of Radiation Oncology, Pharmacology & Cancer Biology
  • Halabi, Susan, Professor of Biostatistics & Bioinformatics, Biostatistics & Bioinformatics
  • Hirschey, Matthew, Associate Professor of Medicine, Cell Biology
  • Krangel, Michael S., George Barth Geller Distinguished Professor of Immunology, Integrative Immunobiology
  • Luftig, Micah Alan, Professor of Molecular Genetics and Microbiology, Cell Biology
  • MacLeod, Amanda S, Adjunct Associate Professor in the Department of Dermatology, Integrative Immunobiology
  • McLendon, Roger Edwin, Professor of Pathology, Pathology
  • Moorman, Patricia Gripka, Professor Emeritus in Family Medicine and Community Health, Duke Cancer Institute
  • Sullivan, Beth Ann, Professor of Molecular Genetics and Microbiology, Duke Science & Society
  • Tsalik, Ephraim, Adjunct Associate Professor in the Department of Medicine, Medicine, Infectious Diseases