DNA Topoisomerases, Type II
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Subject Areas on Research
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A Bacterial Chromosome Structuring Protein Binds Overtwisted DNA to Stimulate Type II Topoisomerases and Enable DNA Replication.
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A unique type II topoisomerase mutant that is hypersensitive to a broad range of cleavage-inducing antitumor agents.
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An antitumor drug-induced topoisomerase cleavage complex blocks a bacteriophage T4 replication fork in vivo.
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Analysis of cleavage complexes using reactive inhibitor derivatives.
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Bacteriophage T4 DNA topoisomerase is the target of antitumor agent 4'-(9-acridinylamino)methanesulfon-m-anisidide (m-AMSA) in T4-infected Escherichia coli.
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Bacteriophage T4 mutants hypersensitive to an antitumor agent that induces topoisomerase-DNA cleavage complexes.
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Bacteriophage T4, a model system for understanding the mechanism of type II topoisomerase inhibitors.
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Carbonic anhydrase IX is a predictive marker of doxorubicin resistance in early-stage breast cancer independent of HER2 and TOP2A amplification.
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Casein kinase II copurifies with yeast DNA topoisomerase II and re-activates the dephosphorylated enzyme.
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Casein kinase II phosphorylates the eukaryote-specific C-terminal domain of topoisomerase II in vivo.
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Comparative value of tumour grade, hormonal receptors, Ki-67, HER-2 and topoisomerase II alpha status as predictive markers in breast cancer patients treated with neoadjuvant anthracycline-based chemotherapy.
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Complex response of breast epithelial cell lines to topoisomerase inhibitors.
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Cytological and genetic consequences for the progeny of a mitotic catastrophe provoked by Topoisomerase II deficiency.
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Dietary isothiocyanate-induced apoptosis via thiol modification of DNA topoisomerase IIα.
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Disruption of a topoisomerase-DNA cleavage complex by a DNA helicase.
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Elevated DNA polymerase alpha, DNA polymerase beta, and DNA topoisomerase II in a melphalan-resistant rhabdomyosarcoma xenograft that is cross-resistant to nitrosoureas and topotecan.
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Escherichia coli mutants thermosensitive for deoxyribonucleic acid gyrase subunit A: effects on deoxyribonucleic acid replication, transcription, and bacteriophage growth.
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Formation and resolution of DNA catenanes by DNA gyrase.
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Function of the hydrophilic carboxyl terminus of type II DNA topoisomerase from Drosophila melanogaster. I. In vitro studies.
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Function of the hydrophilic carboxyl terminus of type II DNA topoisomerase from Drosophila melanogaster. II. In vivo studies.
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Genetic variability of Bacillus anthracis and related species.
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Haploinsufficiency of RanBP2 is neuroprotective against light-elicited and age-dependent degeneration of photoreceptor neurons.
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Hotspot sites for acridine-induced frameshift mutations in bacteriophage T4 correspond to sites of action of the T4 type II topoisomerase.
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International Commission for Protection Against Environmental Mutagens and Carcinogens. Mutagenicity and carcinogenicity of topoisomerase-interactive agents.
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Localization of RAP1 and topoisomerase II in nuclei and meiotic chromosomes of yeast.
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Localization of an aminoacridine antitumor agent in a type II topoisomerase-DNA complex.
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Loss of a histone deacetylase dramatically alters the genomic distribution of Spo11p-catalyzed DNA breaks in Saccharomyces cerevisiae.
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Low levels of DNA polymerase alpha induce mitotic and meiotic instability in the ribosomal DNA gene cluster of Saccharomyces cerevisiae.
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Mitotic recombination in the rDNA of S. cerevisiae is suppressed by the combined action of DNA topoisomerases I and II.
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Multiple DNA repair mechanisms and alkylator resistance in the human medulloblastoma cell line D-283 Med (4-HCR).
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Mutational alteration of the breakage/resealing subunit of bacteriophage T4 DNA topoisomerase confers resistance to antitumor agent m-AMSA.
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Mutational analysis of a type II topoisomerase cleavage site: distinct requirements for enzyme and inhibitors.
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Mutations of the bacteriophage T4 type II DNA topoisomerase that alter sensitivity to antitumor agent 4'-(9-acridinylamino)methanesulfon-m-anisidide and an antibacterial quinolone.
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Phase I clinical and plasma and cellular pharmacological study of topotecan without and with granulocyte colony-stimulating factor.
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Probing conformational changes in human DNA topoisomerase IIα by pulsed alkylation mass spectrometry.
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Purification of the bacteriophage T4 type II DNA topoisomerase.
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Recognition of single-stranded DNA by the bacteriophage T4-induced type II topoisomerase.
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Regulation of L-selectin-mediated rolling through receptor dimerization.
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Regulation of topoisomerase II by phosphorylation: a role for casein kinase II.
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Repair of topoisomerase-mediated DNA damage in bacteriophage T4.
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Role of recombinational repair in sensitivity to an antitumour agent that inhibits bacteriophage T4 type II DNA topoisomerase.
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Site-specific recognition of bacteriophage T4 DNA by T4 type II DNA topoisomerase and Escherichia coli DNA gyrase.
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Structure and activities of Escherichia coli DNA gyrase.
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Targeting nucleolin for better survival in diffuse large B-cell lymphoma.
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The C-terminal 20 Amino Acids of Drosophila Topoisomerase 2 Are Required for Binding to a BRCA1 C Terminus (BRCT) Domain-containing Protein, Mus101, and Fidelity of DNA Segregation.
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The composition and morphology of yeast nuclear scaffolds.
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The regulation of DNA topoisomerase II by casein kinase II.
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The specificity of topoisomerase-mediated DNA cleavage defines acridine-induced frameshift specificity within a hotspot in bacteriophage T4.
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Tirapazamine: a hypoxia-activated topoisomerase II poison.
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Topoisomerase II levels during granulocytic maturation in vitro and in vivo.
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Topoisomerase II: its functions and phosphorylation.
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Trapped topoisomerase II initiates formation of de novo duplications via the nonhomologous end-joining pathway in yeast.
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Unusual chromosome architecture and behaviour at an HSR.