DNA Polymerase I
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Subject Areas on Research
- Arrest of replication by mammalian DNA polymerases alpha and beta caused by chromium-DNA lesions.
- Chromosomal translocations in yeast induced by low levels of DNA polymerase a model for chromosome fragile sites.
- Chromosome aberrations resulting from double-strand DNA breaks at a naturally occurring yeast fragile site composed of inverted ty elements are independent of Mre11p and Sae2p.
- Cocrystal structure of an editing complex of Klenow fragment with DNA.
- Crystal structure of a thermostable Bacillus DNA polymerase I large fragment at 2.1 A resolution.
- Crystal structures of the Klenow fragment of DNA polymerase I complexed with deoxynucleoside triphosphate and pyrophosphate.
- Discrimination between right and wrong purine dNTPs by DNA polymerase I from Bacillus stearothermophilus.
- Dissecting the differences between the alpha and beta anomers of the oxidative DNA lesion FaPydG.
- Elevated DNA polymerase alpha, DNA polymerase beta, and DNA topoisomerase II in a melphalan-resistant rhabdomyosarcoma xenograft that is cross-resistant to nitrosoureas and topotecan.
- Enhanced repair of a cisplatin-damaged reporter chloramphenicol-O-acetyltransferase gene and altered activities of DNA polymerases alpha and beta, and DNA ligase in cells of a human malignant glioma following in vivo cisplatin therapy.
- Enhancement of melphalan activity by inhibition of DNA polymerase-alpha and DNA polymerase-beta.
- Following an environmental carcinogen N2-dG adduct through replication: elucidating blockage and bypass in a high-fidelity DNA polymerase.
- Genetic Reprogramming of Positional Memory in a Regenerating Appendage.
- Genetic and crystallographic studies of the 3',5'-exonucleolytic site of DNA polymerase I.
- Heterogeneous polymerase fidelity and mismatch repair bias genome variation and composition.
- Introduction of the alpha-P-borano-group into deoxynucleoside triphosphates increases their selectivity to HIV-1 reverse transcriptase relative to DNA polymerases.
- Isolation and characterization of the replicon of a Thiobacillus intermedius plasmid.
- Low levels of DNA polymerase alpha induce mitotic and meiotic instability in the ribosomal DNA gene cluster of Saccharomyces cerevisiae.
- Mcm10 and And-1/CTF4 recruit DNA polymerase alpha to chromatin for initiation of DNA replication.
- Mechanisms of DNA-mismatch correction.
- Processive DNA synthesis observed in a polymerase crystal suggests a mechanism for the prevention of frameshift mutations.
- Purification and properties of DNA polymerase-beta from guinea pig liver.
- Role of Escherichia coli DNA polymerase I in conferring viability upon the dnaN159 mutant strain.
- Structural basis for the 3'-5' exonuclease activity of Escherichia coli DNA polymerase I: a two metal ion mechanism.
- Structural studies of Klenow fragment: an enzyme with two active sites.
- Structure of DNA polymerase I Klenow fragment bound to duplex DNA.
- The Closing Mechanism of DNA Polymerase I at Atomic Resolution.
- The mechanism of the translocation step in DNA replication by DNA polymerase I: a computer simulation analysis.
- The structure of a high fidelity DNA polymerase bound to a mismatched nucleotide reveals an "ajar" intermediate conformation in the nucleotide selection mechanism.
- Tn5-mediated bleomycin resistance in Escherichia coli requires the expression of host genes.
- Two DNA polymerases: HIV reverse transcriptase and the Klenow fragment of Escherichia coli DNA polymerase I.
- Visualizing DNA replication in a catalytically active Bacillus DNA polymerase crystal.