DNA Repair

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  Subject Areas on Research

  • 172G>T variant in the 5' untranslated region of DNA repair gene RAD51 reduces risk of squamous cell carcinoma of the head and neck and interacts with a P53 codon 72 variant. 
  • A Cross-Cancer Genetic Association Analysis of the DNA Repair and DNA Damage Signaling Pathways for Lung, Ovary, Prostate, Breast, and Colorectal Cancer. 
  • A bacteriophage model system for studying topoisomerase inhibitors. 
  • A defined human system that supports bidirectional mismatch-provoked excision. 
  • A fine-structure map of spontaneous mitotic crossovers in the yeast Saccharomyces cerevisiae. 
  • A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia. 
  • A methylation-dependent electrostatic switch controls DNA repair and transcriptional activation by E. coli ada. 
  • A modified host-cell reactivation assay to measure repair of alkylating DNA damage for assessing risk of lung adenocarcinoma. 
  • A mutation of the yeast gene encoding PCNA destabilizes both microsatellite and minisatellite DNA sequences. 
  • A naturally occurring hPMS2 mutation can confer a dominant negative mutator phenotype. 
  • A new assay to quantify in vivo repair of G:T mispairs by base excision repair. 
  • A promoter polymorphism (-77T>C) of DNA repair gene XRCC1 is associated with risk of lung cancer in relation to tobacco smoking. 
  • A variant of the DNA repair gene XRCC3 and risk of squamous cell carcinoma of the head and neck: a case-control analysis. 
  • ATM Paradoxically Promotes Oncogenic Transformation via Transcriptional Reprogramming. 
  • ATM regulates a DNA damage response posttranscriptional RNA operon in lymphocytes. 
  • ATR functions as a gene dosage-dependent tumor suppressor on a mismatch repair-deficient background. 
  • Abasic sites in the transcribed strand of yeast DNA are removed by transcription-coupled nucleotide excision repair. 
  • Adenine Fine-Tunes DNA Photolyase's Repair Mechanism. 
  • Aged human muscle demonstrates an altered gene expression profile consistent with an impaired response to exercise. 
  • Alleles of the yeast Pms1 mismatch-repair gene that differentially affect recombination- and replication-related processes. 
  • Amino acid changes in Xrs2p, Dun1p, and Rfa2p that remove the preferred targets of the ATM family of protein kinases do not affect DNA repair or telomere length in Saccharomyces cerevisiae. 
  • An ERCC4 regulatory variant predicts grade-3 or -4 toxicities in patients with advanced non-small cell lung cancer treated by platinum-based therapy. 
  • An alkylation-tolerant, mutator human cell line is deficient in strand-specific mismatch repair. 
  • An analysis of DNA repair as a determinant of survival in patients with non-small-cell lung cancer. 
  • An analysis of single nucleotide polymorphisms of 125 DNA repair genes in the Texas genome-wide association study of lung cancer with a replication for the XRCC4 SNPs. 
  • An antitumor drug-induced topoisomerase cleavage complex blocks a bacteriophage T4 replication fork in vivo. 
  • An expanded risk prediction model for lung cancer. 
  • An intronic poly (AT) polymorphism of the DNA repair gene XPC and risk of squamous cell carcinoma of the head and neck: a case-control study. 
  • Analysis of DNA damage and repair in nuclear and mitochondrial DNA of animal cells using quantitative PCR. 
  • Analysis of DNA mismatch repair proteins in human medulloblastoma. 
  • Analysis of a gene conversion gradient at the HIS4 locus in Saccharomyces cerevisiae. 
  • Analysis of the proteins involved in the in vivo repair of base-base mismatches and four-base loops formed during meiotic recombination in the yeast Saccharomyces cerevisiae. 
  • Antitumor activity of temozolomide combined with irinotecan is partly independent of O6-methylguanine-DNA methyltransferase and mismatch repair phenotypes in xenograft models. 
  • Assessment of protein dynamics and DNA repair following generation of DNA double-strand breaks at defined genomic sites. 
  • Association and interactions between DNA repair gene polymorphisms and adult glioma. 
  • Association between DNA damage response and repair genes and risk of invasive serous ovarian cancer. 
  • Association between IHC and MSI testing to identify mismatch repair-deficient patients with ovarian cancer. 
  • Association between family history of cancer and mutagen sensitivity in upper aerodigestive tract cancer patients. 
  • Association between low dietary folate intake and suboptimal cellular DNA repair capacity. 
  • Association between miRNA-binding site polymorphisms in double-strand break repair genes and risk of recurrence in patients with squamous cell carcinomas of the non-oropharynx. 
  • Association between the V109G polymorphism of the p27 gene and the risk and progression of oral squamous cell carcinoma. 
  • Association of germline rare pathogenic mutations in guideline-recommended genes with prostate cancer progression: A meta-analysis. 
  • Association of increased spontaneous mutation rates with high levels of transcription in yeast. 
  • Associations of Lys939Gln and Ala499Val polymorphisms of the XPC gene with cancer susceptibility: a meta-analysis. 
  • BLM-DNA2-RPA-MRN and EXO1-BLM-RPA-MRN constitute two DNA end resection machineries for human DNA break repair. 
  • Bacteriophage T4 UvsW protein is a helicase involved in recombination, repair and the regulation of DNA replication origins. 
  • Bacteriophage T4, a model system for understanding the mechanism of type II topoisomerase inhibitors. 
  • Base composition of mononucleotide runs affects DNA polymerase slippage and removal of frameshift intermediates by mismatch repair in Saccharomyces cerevisiae. 
  • Basic mechanisms of therapeutic resistance to radiation and chemotherapy in lung cancer. 
  • Bat3 facilitates H3K79 dimethylation by DOT1L and promotes DNA damage-induced 53BP1 foci at G1/G2 cell-cycle phases. 
  • Bayesian hierarchically weighted finite mixture models for samples of distributions. 
  • Bidirectional excision in methyl-directed mismatch repair. 
  • Biochemical correlates of temozolomide sensitivity in pediatric solid tumor xenograft models. 
  • Biomarkers in the endometrium. 
  • Caenorhabditis elegans DNA mismatch repair gene msh-2 is required for microsatellite stability and maintenance of genome integrity. 
  • Caenorhabditis elegans generates biologically relevant levels of genotoxic metabolites from aflatoxin B1 but not benzo[a]pyrene in vivo 
  • Carcinogen induced unscheduled DNA synthesis in mouse hepatocytes. 
  • Carcinogen-induced unscheduled DNA synthesis in xenotransplanted human tracheobronchial epithelium: comparison with rat tracheal epithelium. 
  • Carcinogenesis in urogenital sites. 
  • Carcinogenic effects of hyperthermia. 
  • Cell-extrinsic consequences of epithelial stress: activation of protumorigenic tissue phenotypes. 
  • Cells with pathogenic biallelic mutations in the human MUTYH gene are defective in DNA damage binding and repair. 
  • Cellular mechanisms of cyclophosphamide resistance: model studies in human medulloblastoma cell lines. 
  • Characterization of DNA lesions induced by CaCrO4 in synchronous and asynchronous cultured mammalian cells. 
  • Characterization of reaction intermediates of human excision repair nuclease. 
  • Characterization of the repeat-tract instability and mutator phenotypes conferred by a Tn3 insertion in RFC1, the large subunit of the yeast clamp loader. 
  • Characterization of tumor mutation burden, PD-L1 and DNA repair genes to assess relationship to immune checkpoint inhibitors response in metastatic renal cell carcinoma. 
  • Charting the landscape of tandem BRCT domain-mediated protein interactions. 
  • Checkpoint controls and cancer. Introduction. 
  • Chromatin perturbations during the DNA damage response in higher eukaryotes. 
  • Chromium (VI) at plausible drinking water concentrations is not genotoxic in the in vivo bone marrow micronucleus or liver unscheduled DNA synthesis assays. 
  • Chromium genotoxicity: A double-edged sword. 
  • Chromosomal translocations in yeast induced by low levels of DNA polymerase a model for chromosome fragile sites. 
  • Chromosome rearrangements via template switching between diverged repeated sequences. 
  • Chromosomes with high gene density are preferentially repaired in human cells. 
  • Chronic cisplatin treatment promotes enhanced damage repair and tumor progression in a mouse model of lung cancer. 
  • Chronic oxidative DNA damage due to DNA repair defects causes chromosomal instability in Saccharomyces cerevisiae. 
  • Cisplatin and adriamycin resistance are associated with MutLalpha and mismatch repair deficiency in an ovarian tumor cell line. 
  • Clinical and Genomic Characterization of Treatment-Emergent Small-Cell Neuroendocrine Prostate Cancer: A Multi-institutional Prospective Study. 
  • CometChip enables parallel analysis of multiple DNA repair activities. 
  • Common non-epigenetic drugs as epigenetic modulators. 
  • Comparative analyses of two primate species diverged by more than 60 million years show different rates but similar distribution of genome-wide UV repair events. 
  • Comparative genome-wide screening identifies a conserved doxorubicin repair network that is diploid specific in Saccharomyces cerevisiae. 
  • Complexities of chromium carcinogenesis: role of cellular response, repair and recovery mechanisms. 
  • Comprehensive genomic characterization defines human glioblastoma genes and core pathways. 
  • Comprehensive genomic profiling of pancreatic acinar cell carcinomas identifies recurrent RAF fusions and frequent inactivation of DNA repair genes. 
  • Conditional dicentric chromosomes in yeast. 
  • Conserved function of Drosophila Fancd2 monoubiquitination in response to double-strand DNA breaks. 
  • Conserved motifs II to VI of DNA helicase II from Escherichia coli are all required for biological activity. 
  • Conversion-type and restoration-type repair of DNA mismatches formed during meiotic recombination in Saccharomyces cerevisiae. 
  • Coordination of DNA ends during double-strand-break repair in bacteriophage T4. 
  • Correction for differences in germ cell stage sensitivity in risk assessment. 
  • Correlation between Charge Transport and Base Excision Repair in the MutY-DNA Glycosylase. 
  • Correlation between base-excision repair gene polymorphisms and levels of in-vitro BPDE-induced DNA adducts in cultured peripheral blood lymphocytes. 
  • Correlation of DNA fragmentation and chromatin condensation in apoptotic nuclei of the Ser 6 mouse retina. 
  • Coupling of human DNA excision repair and the DNA damage checkpoint in a defined in vitro system. 
  • DEK is required for homologous recombination repair of DNA breaks. 
  • DHFR/MSH3 amplification in methotrexate-resistant cells alters the hMutSalpha/hMutSbeta ratio and reduces the efficiency of base-base mismatch repair. 
  • DNA Damage Responses during the Cell Cycle: Insights from Model Organisms and Beyond. 
  • DNA chain length dependence of formation and dynamics of hMutSalpha.hMutLalpha.heteroduplex complexes. 
  • DNA damage and repair in Parkinson's disease: Recent advances and new opportunities. 
  • DNA damage responses in prokaryotes: regulating gene expression, modulating growth patterns, and manipulating replication forks. 
  • DNA interstrand crosslinking and strand break repair in human glioma cell lines of varying [1,3-bis(2-chloroethyl)-1-nitrosourea] resistance. 
  • DNA mismatch correction in a defined system. 
  • DNA mismatch correction. 
  • DNA mismatch repair and O6-alkylguanine-DNA alkyltransferase analysis and response to Temodal in newly diagnosed malignant glioma. 
  • DNA mismatch repair and genetic instability. 
  • DNA mismatch repair: functions and mechanisms. 
  • DNA nicks inflicted by restriction endonucleases are repaired by a RecA- and RecB-dependent pathway in Escherichia coli. 
  • DNA polymerase delta is required for human mismatch repair in vitro. 
  • DNA polymerase zeta introduces multiple mutations when bypassing spontaneous DNA damage in Saccharomyces cerevisiae. 
  • DNA repair and aging in basal cell carcinoma: a molecular epidemiology study. 
  • DNA repair and epidemiology of basal cell carcinoma. 
  • DNA repair and susceptibility to basal cell carcinoma: a case-control study. 
  • DNA repair capacity and lung cancer risk in never smokers. 
  • DNA repair capacity for ultraviolet light-induced damage is reduced in peripheral lymphocytes from patients with basal cell carcinoma. 
  • DNA repair capacity in healthy medical students during and after exam stress. 
  • DNA repair capacity in peripheral lymphocytes predicts survival of patients with non-small-cell lung cancer treated with first-line platinum-based chemotherapy. 
  • DNA repair gene ERCC1 and ERCC2/XPD polymorphisms and risk of squamous cell carcinoma of the head and neck. 
  • DNA repair gene XPC genotypes/haplotypes and risk of lung cancer in a Chinese population. 
  • DNA repair gene XPD polymorphism and lung cancer risk: a meta-analysis. 
  • DNA repair gene XRCC3 241Met variant is not associated with risk of cutaneous malignant melanoma. 
  • DNA repair gene polymorphisms and risk of pancreatic cancer. 
  • DNA repair genes: contributions to prostate cancer predisposition and aggressiveness. 
  • DNA repair in human leukaemic lymphocytes. 
  • DNA repair in lymphoblastoid cell lines from patients with head and neck cancer. 
  • DNA repair mechanisms and the bypass of DNA damage in Saccharomyces cerevisiae. 
  • DNA repair phenotype and cancer susceptibility--a mini review. 
  • DNA repair proteins are directly involved in regulation of gene expression during plant immune response. 
  • DNA repair related to multiple skin cancers and drug use. 
  • DNA repair synthesis after x-irradiation in E. coli. 
  • DNA repair synthesis in isolated rainbow trout liver cells. 
  • DNA repair: a double-edged sword. 
  • DNA sequence specificity of doxorubicin-induced mutational damage in uvrB- Escherichia coli. 
  • DNA strand breaks: the DNA template alterations that trigger p53-dependent DNA damage response pathways. 
  • DNA-XPA interactions: a (31)P NMR and molecular modeling study of dCCAATAACC association with the minimal DNA-binding domain (M98-F219) of the nucleotide excision repair protein XPA. 
  • DNA-dependent activation of the hMutSalpha ATPase. 
  • DNA: wire or insulator? 
  • Decline of nucleotide excision repair capacity in aging Caenorhabditis elegans. 
  • Defective dendritic cell maturation in a child with nucleotide excision repair deficiency and CD4 lymphopenia. 
  • Deficiency of double-strand DNA break repair does not impair Mycobacterium tuberculosis virulence in multiple animal models of infection. 
  • Delineating the requirements for spontaneous DNA damage resistance pathways in genome maintenance and viability in Saccharomyces cerevisiae. 
  • Destabilization of simple repetitive DNA sequences by transcription in yeast. 
  • Destabilization of tracts of simple repetitive DNA in yeast by mutations affecting DNA mismatch repair. 
  • Detection of DNA damage in transcriptionally active genes by RT-PCR and assessment of repair of cisplatin-induced damage in the glutathione S-transferase-pi gene in human glioblastoma cells. 
  • Determinants of Photolyase's DNA Repair Mechanism in Mesophiles and Extremophiles. 
  • Diagnosis of immunodeficiency caused by a purine nucleoside phosphorylase defect by using tandem mass spectrometry on dried blood spots. 
  • Dietary magnesium and DNA repair capacity as risk factors for lung cancer. 
  • Differential and simultaneous adenosine di- and triphosphate binding by MutS. 
  • Differential specificities and simultaneous occupancy of human MutSalpha nucleotide binding sites. 
  • Direct correlation between DNA repair capacity and metastatic potential of K-1735 murine melanoma cells. 
  • Direct ribosomal binding by a cellular inhibitor of translation. 
  • Discrete in vivo roles for the MutL homologs Mlh2p and Mlh3p in the removal of frameshift intermediates in budding yeast. 
  • Dissociation of radiation-induced phosphorylation of replication protein A from the S-phase checkpoint. 
  • Distinct MutS DNA-binding modes that are differentially modulated by ATP binding and hydrolysis. 
  • Distinctive adaptive response to repeated exposure to hydrogen peroxide associated with upregulation of DNA repair genes and cell cycle arrest. 
  • Distribution of repair-incorporated nucleotides and nucleosome rearrangement in the chromatin of normal and xeroderma pigmentosum human fibroblasts. 
  • Diverse hypermutability of multiple expressed sequence motifs present in a cancer with microsatellite instability. 
  • Double-strand break repair in tandem repeats during bacteriophage T4 infection. 
  • Double-strand breaks associated with repetitive DNA can reshape the genome. 
  • Dual roles for DNA sequence identity and the mismatch repair system in the regulation of mitotic crossing-over in yeast. 
  • ENTPD1 (CD39) Expression Inhibits UVR-Induced DNA Damage Repair through Purinergic Signaling and Is Associated with Metastasis in Human Cutaneous Squamous Cell Carcinoma. 
  • Editor's Highlight: Base Excision Repair Variants and Pesticide Exposure Increase Parkinson's Disease Risk. 
  • Effect of aging on DNA repair and skin carcinogenesis: a minireview of population-based studies. 
  • Effect of di(2-ethylhexyl) phthalate on DNA repair and lipid peroxidation in rat hepatocytes and on metabolic cooperation in Chinese hamster V-79 cells. 
  • Effect of mutations in genes affecting homologous recombination on restriction enzyme-mediated and illegitimate recombination in Saccharomyces cerevisiae. 
  • Effects of base excision repair gene polymorphisms on pancreatic cancer survival. 
  • Effects of hexavalent chromium on the survival and cell cycle distribution of DNA repair-deficient S. cerevisiae. 
  • Effects of high levels of DNA adenine methylation on methyl-directed mismatch repair in Escherichia coli. 
  • Effects of methyl and inorganic mercury exposure on genome homeostasis and mitochondrial function in Caenorhabditis elegans. 
  • Effects of mismatch repair and Hpr1 on transcription-stimulated mitotic recombination in the yeast Saccharomyces cerevisiae. 
  • Emerging predictive biomarkers in the management of bone and soft tissue sarcomas. 
  • Endonucleolytic function of MutLalpha in human mismatch repair. 
  • Enhanced repair of a cisplatin-damaged reporter chloramphenicol-O-acetyltransferase gene and altered activities of DNA polymerases alpha and beta, and DNA ligase in cells of a human malignant glioma following in vivo cisplatin therapy. 
  • Escherichia coli K-12 clones that overproduce dam methylase are hypermutable. 
  • Escherichia coli mutS-encoded protein binds to mismatched DNA base pairs. 
  • Escherichia coli mutY gene encodes an adenine glycosylase active on G-A mispairs. 
  • Escherichia coli mutY gene product is required for specific A-G----C.G mismatch correction. 
  • Estimation of the effects of smoking and DNA repair capacity on coefficients of a carcinogenesis model for lung cancer. 
  • Etiology of the mutational spectrum of ras genes in human carcinomas. 
  • Evaluating and enhancing ribozyme reaction efficiency in mammalian cells. 
  • Excision repair is required for genotoxin-induced mutagenesis in mammalian cells. 
  • Excision repair reduces doxorubicin-induced genotoxicity. 
  • Experience and activity-dependent maturation of perisomatic GABAergic innervation in primary visual cortex during a postnatal critical period. 
  • Expression and function of the uvsW gene of bacteriophage T4. 
  • Expression in normal human tissues of five nucleotide excision repair genes measured simultaneously by multiplex reverse transcription-polymerase chain reaction. 
  • Expression of O6-alkylguanine-DNA alkyltransferase in Mer+ and Mer- human cell extracts probed with specific monoclonal antibodies. 
  • Expression of five selected human mismatch repair genes simultaneously detected in normal and cancer cell lines by a nonradioactive multiplex reverse transcription-polymerase chain reaction. 
  • Expression of nucleotide excision repair genes and the risk for squamous cell carcinoma of the head and neck. 
  • Expression of nucleotide excision repair proteins in lymphocytes as a marker of susceptibility to squamous cell carcinomas of the head and neck. 
  • FANCD2 monoubiquitination and activation by hexavalent chromium [Cr(VI)] exposure: activation is not required for repair of Cr(VI)-induced DSBs. 
  • Fanconi anemia complementation group A cells are hypersensitive to chromium(VI)-induced toxicity. 
  • Fine-scale mapping of recombination rate in Drosophila refines its correlation to diversity and divergence. 
  • Fluorescence in situ hybridization method for measuring transfection efficiency. 
  • Formaldehyde-induced mutagenesis in Saccharomyces cerevisiae: molecular properties and the roles of repair and bypass systems. 
  • Formation and repair of 1,3-bis-(2-chloroethyl)-1-nitrosourea and cisplatin induced total genomic DNA interstrand crosslinks in human glioma cells. 
  • Frameshift intermediates in homopolymer runs are removed efficiently by yeast mismatch repair proteins. 
  • Frameshifts and deletions during in vitro translesion synthesis past Pt-DNA adducts by DNA polymerases beta and eta. 
  • Functional polymorphisms of base excision repair genes XRCC1 and APEX1 predict risk of radiation pneumonitis in patients with non-small cell lung cancer treated with definitive radiation therapy. 
  • Functions of MutLalpha, replication protein A (RPA), and HMGB1 in 5'-directed mismatch repair. 
  • Functions that protect Escherichia coli from DNA-protein crosslinks. 
  • Gamma-radiation sensitivity and risk of glioma. 
  • Gap formation is associated with methyl-directed mismatch correction under conditions of restricted DNA synthesis. 
  • Gastrostomy in oropharyngeal cancer patients with ERCC4 (XPF) germline variants. 
  • Genetic and enzymatic characterization of a conditional lethal mutant of Escherichia coli K12 with a temperature-sensitive DNA ligase. 
  • Genetic control of microsatellite stability. 
  • Genetic evidence for preferential strand transfer during meiotic recombination in yeast. 
  • Genetic instability and tumorigenesis: introduction. 
  • Genetic polymorphisms in DNA base-excision repair genes ADPRT, XRCC1, and APE1 and the risk of squamous cell carcinoma of the head and neck. 
  • Genetic polymorphisms modify bladder cancer recurrence and survival in a USA population-based prognostic study. 
  • Genetic polymorphisms of selected DNA repair genes, estrogen and progesterone receptor status, and breast cancer risk. 
  • Genetic susceptibility to lung cancer: the role of DNA damage and repair. 
  • Genetic susceptibility to tobacco carcinogenesis. 
  • Genetic variant in DNA repair gene GTF2H4 is associated with lung cancer risk: a large-scale analysis of six published GWAS datasets in the TRICL consortium. 
  • Genetic variants in microRNA-binding sites of DNA repair genes as predictors of recurrence in patients with squamous cell carcinoma of the oropharynx. 
  • Genetic variants in nucleotide excision repair pathway predict survival of esophageal squamous cell cancer patients receiving platinum-based chemotherapy. 
  • Genetic variants of DNA repair genes predict the survival of patients with esophageal squamous cell cancer receiving platinum-based adjuvant chemotherapy. 
  • Genetic variants of genes in the NER pathway associated with risk of breast cancer: A large-scale analysis of 14 published GWAS datasets in the DRIVE study. 
  • Genome-wide analysis of genomic alterations induced by oxidative DNA damage in yeast. 
  • Genome-wide association study reveals novel genetic determinants of DNA repair capacity in lung cancer. 
  • Genotypes and haplotypes of ERCC1 and ERCC2/XPD genes predict levels of benzo[a]pyrene diol epoxide-induced DNA adducts in cultured primary lymphocytes from healthy individuals: a genotype-phenotype correlation analysis. 
  • Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. 
  • HIF-1alpha induces genetic instability by transcriptionally downregulating MutSalpha expression. 
  • Hereditary nonpolyposis colorectal cancer: preventive management. 
  • Heteroduplex DNA position defines the roles of the Sgs1, Srs2, and Mph1 helicases in promoting distinct recombination outcomes. 
  • High frequency of hypermethylation at the 14-3-3 sigma locus leads to gene silencing in breast cancer. 
  • High rate of CAD gene amplification in human cells deficient in MLH1 or MSH6. 
  • High rates of "unselected" aneuploidy and chromosome rearrangements in tel1 mec1 haploid yeast strains. 
  • High-Resolution Mapping of Homologous Recombination Events in rad3 Hyper-Recombination Mutants in Yeast. 
  • High-resolution mapping of spontaneous mitotic recombination hotspots on the 1.1 Mb arm of yeast chromosome IV. 
  • High-resolution mapping of two types of spontaneous mitotic gene conversion events in Saccharomyces cerevisiae. 
  • Histone demethylase AMX-1 is necessary for proper sensitivity to interstrand crosslink DNA damage. 
  • Human CD34+ hematopoietic progenitors have low, cytokine-unresponsive O6-alkylguanine-DNA alkyltransferase and are sensitive to O6-benzylguanine plus BCNU. 
  • Human MutSalpha recognizes damaged DNA base pairs containing O6-methylguanine, O4-methylthymine, or the cisplatin-d(GpG) adduct. 
  • Human T-cell leukemia virus type 1 tax attenuates the ATM-mediated cellular DNA damage response. 
  • Human exonuclease 1 and BLM helicase interact to resect DNA and initiate DNA repair. 
  • Human exonuclease I is required for 5' and 3' mismatch repair. 
  • Human mismatch repair: reconstitution of a nick-directed bidirectional reaction. 
  • Human mitochondrial DNA polymerase gamma exhibits potential for bypass and mutagenesis at UV-induced cyclobutane thymine dimers 
  • Human nucleotide excision repair protein XPA: NMR spectroscopic studies of an XPA fragment containing the ERCC1-binding region and the minimal DNA-binding domain (M59-F219). 
  • Human papillomavirus type 16 E7 oncoprotein causes a delay in repair of DNA damage. 
  • Human strand-specific mismatch repair occurs by a bidirectional mechanism similar to that of the bacterial reaction. 
  • Hypermutability and mismatch repair deficiency in RER+ tumor cells. 
  • Identification of a strand-related bias in the PCNA-mediated bypass of spontaneous lesions by yeast Poleta. 
  • Identification of genetic variants in base excision repair pathway and their associations with risk of esophageal squamous cell carcinoma. 
  • Identification of inhibitory autophosphorylation sites in casein kinase I epsilon. 
  • Imaging molecular pathways: reporter genes. 
  • Immunohistochemical detection of the DNA repair enzyme O6-methylguanine-DNA methyltransferase in formalin-fixed, paraffin-embedded astrocytomas. 
  • In vitro BPDE-induced DNA adducts in peripheral lymphocytes as a risk factor for squamous cell carcinoma of the head and neck. 
  • In vitro benzo[a]pyrene diol epoxide-induced DNA damage and chromosomal aberrations in primary lymphocytes, smoking, and risk of squamous cell carcinoma of the head and neck. 
  • In vitro expression levels of cell-cycle checkpoint proteins are associated with cellular DNA repair capacity in peripheral blood lymphocytes: a multivariate analysis. 
  • In vitro induction of benzo(a)pyrene diol epoxide-DNA adducts in peripheral lymphocytes as a susceptibility marker for human lung cancer. 
  • In vitro repair synthesis of BCNU-induced DNA damage. 
  • In vivo repair of alkylating and oxidative DNA damage in the mitochondrial and nuclear genomes of wild-type and glycosylase-deficient Caenorhabditis elegans 
  • In vivo requirement for RecJ, ExoVII, ExoI, and ExoX in methyl-directed mismatch repair. 
  • Inactivation of nuclear GSK3β by Ser(389) phosphorylation promotes lymphocyte fitness during DNA double-strand break response. 
  • Incision of trivalent chromium [Cr(III)]-induced DNA damage by Bacillus caldotenax UvrABC endonuclease. 
  • Increased DNA excision-repair as pathogenesis of a human leukemia. 
  • Increased rates of genomic deletions generated by mutations in the yeast gene encoding DNA polymerase delta or by decreases in the cellular levels of DNA polymerase delta. 
  • Increased transversions in a novel mutator colon cancer cell line. 
  • Induction of wild-type p53 activity in human cancer cells by ribozymes that repair mutant p53 transcripts. 
  • Initiation of methyl-directed mismatch repair. 
  • Inner nuclear envelope proteins SUN1 and SUN2 play a prominent role in the DNA damage response. 
  • Insights into Watson-Crick/Hoogsteen breathing dynamics and damage repair from the solution structure and dynamic ensemble of DNA duplexes containing m1A. 
  • Instability of a plasmid-borne inverted repeat in Saccharomyces cerevisiae. 
  • Interaction of FANCD2 and NBS1 in the DNA damage response. 
  • Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigen. 
  • Interactions of human nucleotide excision repair protein XPA with DNA and RPA70 Delta C327: chemical shift mapping and 15N NMR relaxation studies. 
  • Intercellular trafficking of the nuclear oncoprotein DEK. 
  • Interplay between DNA replication and recombination in prokaryotes. 
  • Interplay of catalysis, fidelity, threading, and processivity in the exo- and endonucleolytic reactions of human exonuclease I. 
  • Intraarterial O6-benzylguanine enables the specific therapy of nitrosourea-resistant intracranial human glioma xenografts in athymic rats with 1,3-bis(2-chloroethyl)-1-nitrosourea. 
  • Inverted DNA repeats channel repair of distant double-strand breaks into chromatid fusions and chromosomal rearrangements. 
  • Involvement of the beta clamp in methyl-directed mismatch repair in vitro. 
  • Involvement of two endonuclease III homologs in the base excision repair pathway for the processing of DNA alkylation damage in Saccharomyces cerevisiae. 
  • Ionizing radiation-induced DNA damage, response, and repair. 
  • Isolation and characterization of point mutations in mismatch repair genes that destabilize microsatellites in yeast. 
  • Isolation and characterization of the Escherichia coli mutL gene product. 
  • Isolation of MutSbeta from human cells and comparison of the mismatch repair specificities of MutSbeta and MutSalpha. 
  • Isolation of SOS constitutive mutants of Escherichia coli. 
  • Isolation of an hMSH2-p160 heterodimer that restores DNA mismatch repair to tumor cells. 
  • Joint effects of dietary trace metals and DNA repair capacity in lung cancer risk. 
  • Joint effects of single nucleotide polymorphisms in P53BP1 and p53 on breast cancer risk in a Chinese population. 
  • KLK3 germline mutation I179T complements DNA repair genes for predicting prostate cancer progression. 
  • Kinetics of bisulfite-induced cytosine deamination in single-stranded DNA. 
  • LRRK2 mutations cause mitochondrial DNA damage in iPSC-derived neural cells from Parkinson's disease patients: reversal by gene correction. 
  • Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility and BRCA1-mediated DNA repair. 
  • Local nucleosome dynamics and eviction following a double-strand break are reversible by NHEJ-mediated repair in the absence of DNA replication. 
  • Loss of ARID1A in Tumor Cells Renders Selective Vulnerability to Combined Ionizing Radiation and PARP Inhibitor Therapy. 
  • Loss of Dependence on Continued Expression of the Human Papillomavirus 16 E7 Oncogene in Cervical Cancers and Precancerous Lesions Arising in Fanconi Anemia Pathway-Deficient Mice. 
  • Loss of KAI1 expression in the progression of colorectal cancer. 
  • Low-level exposures to chemical carcinogens: mutational end points. 
  • MCL-319 LP-284 - A Highly Potent Small Molecule Targeting Mantle Cell Lymphoma. 
  • MSH6, a Saccharomyces cerevisiae protein that binds to mismatches as a heterodimer with MSH2. 
  • Manganese superoxide dismutase is a mitochondrial fidelity protein that protects Polγ against UV-induced inactivation. 
  • Mapping oxidative DNA damage and mechanisms of repair. 
  • Mapping oxidative DNA damage using ligation-mediated polymerase chain reaction technology. 
  • Mathematical modeling: epidemiology meets systems biology. 
  • Measurements of excision repair tracts formed during meiotic recombination in Saccharomyces cerevisiae. 
  • Mechanism of 5'-directed excision in human mismatch repair. 
  • Mechanisms and biological effects of mismatch repair. 
  • Mechanisms in eukaryotic mismatch repair. 
  • Mechanisms of DNA-mismatch correction. 
  • Meiotic recombination involving heterozygous large insertions in Saccharomyces cerevisiae: formation and repair of large, unpaired DNA loops. 
  • Methyl-directed DNA mismatch correction. 
  • Methyl-directed DNA mismatch repair in Escherichia coli. 
  • Methyl-directed mismatch repair is bidirectional. 
  • Methyl-directed repair of DNA base-pair mismatches in vitro. 
  • Methyl-directed repair of DNA base-pair mismatches in vitro. 1983. 
  • Methylation of deoxycytidine incorporated by excision-repair synthesis of DNA. 
  • Methylator resistance mediated by mismatch repair deficiency in a glioblastoma multiforme xenograft. 
  • Microsatellite instability in gynecological sarcomas and in hMSH2 mutant uterine sarcoma cell lines defective in mismatch repair activity. 
  • Microsatellite instability in yeast: dependence on repeat unit size and DNA mismatch repair genes. 
  • Mismatch correction. 
  • Mismatch recognition and subsequent processing have distinct effects on mitotic recombination intermediates and outcomes in yeast. 
  • Mismatch repair and genetic stability in human cells. 
  • Mismatch repair deficiency in phenotypically normal human cells. 
  • Mismatch repair in replication fidelity, genetic recombination, and cancer biology. 
  • Mismatch repair proteins MutS and MutL inhibit RecA-catalyzed strand transfer between diverged DNAs. 
  • Mismatch repair proteins and mitotic genome stability. 
  • Mismatch repair proteins regulate heteroduplex formation during mitotic recombination in yeast. 
  • Mismatch repair, genetic stability and tumour avoidance. 
  • Mismatch repair, genetic stability, and cancer. 
  • Mismatch repair-dependent iterative excision at irreparable O6-methylguanine lesions in human nuclear extracts. 
  • Mismatch-, MutS-, MutL-, and helicase II-dependent unwinding from the single-strand break of an incised heteroduplex. 
  • Mispair specificity of methyl-directed DNA mismatch correction in vitro. 
  • Mitochondrial DNA damage induced autophagy, cell death, and disease. 
  • Mitotic crossovers between diverged sequences are regulated by mismatch repair proteins in Saccaromyces cerevisiae. 
  • Mitotic recombination in yeast: what we know and what we don't know. 
  • Modulation of MutS ATP hydrolysis by DNA cofactors. 
  • Modulation of nucleotide excision repair capacity by XPD polymorphisms in lung cancer patients. 
  • Molecular basis of endometrial cancer. 
  • Molecular cross-talk among chromosome fragility syndromes. 
  • Molecular determinants of sensitivity to antitumor agents. 
  • Molecular structures of crossover and noncrossover intermediates during gap repair in yeast: implications for recombination. 
  • Mouse embryonic stem cells carrying one or two defective Msh2 alleles respond abnormally to oxidative stress inflicted by low-level radiation. 
  • Multifaceted recognition of vertebrate Rev1 by translesion polymerases ζ and κ. 
  • Multiple DNA repair mechanisms and alkylator resistance in the human medulloblastoma cell line D-283 Med (4-HCR). 
  • Multiple roles of ATM in monitoring and maintaining DNA integrity. 
  • MutLalpha and proliferating cell nuclear antigen share binding sites on MutSbeta. 
  • MutS and MutL activate DNA helicase II in a mismatch-dependent manner. 
  • MutS mediates heteroduplex loop formation by a translocation mechanism. 
  • Mutagen sensitivity and risk of gliomas: a case-control analysis. 
  • Mutagenesis and the three R's in yeast. 
  • Mutagenic repair of a ZFN-induced double-strand break in yeast: Effects of cleavage site sequence and spacer size. 
  • Mutation detection with MutH, MutL, and MutS mismatch repair proteins. 
  • Mutation in the mismatch repair gene Msh6 causes cancer susceptibility. 
  • Mutation of MSH3 in endometrial cancer and evidence for its functional role in heteroduplex repair. 
  • Mutations in WDR62, encoding a centrosome-associated protein, cause microcephaly with simplified gyri and abnormal cortical architecture. 
  • Nanoparticle delivery of chemosensitizers improve chemotherapy efficacy without incurring additional toxicity. 
  • Nanopore sequencing of complex genomic rearrangements in yeast reveals mechanisms of repeat-mediated double-strand break repair. 
  • New Insights into the Post-Translational Regulation of DNA Damage Response and Double-Strand Break Repair in Caenorhabditis elegans. 
  • New findings in the chromosome 13 long-arm deletion syndrome and retinoblastoma. 
  • Niraparib in patients with metastatic castration-resistant prostate cancer and DNA repair gene defects (GALAHAD): a multicentre, open-label, phase 2 trial. 
  • No detectable DNA excision repair in UV-exposed hepatocytes from two catfish species. 
  • Non-canonical roles of apoptotic and DNA double-strand break repair factors in mediating cellular response to ionizing radiation. 
  • Novel PMS1 alleles preferentially affect the repair of primer strand loops during DNA replication. 
  • Nuclear basic fibroblast growth factor regulates triple-negative breast cancer chemo-resistance. 
  • Nucleolar organization, ribosomal DNA array stability, and acrocentric chromosome integrity are linked to telomere function. 
  • Nucleotide excision repair as a marker for susceptibility to tobacco-related cancers: a review of molecular epidemiological studies. 
  • Nucleotide excision repair core gene polymorphisms and risk of second primary malignancy in patients with index squamous cell carcinoma of the head and neck. 
  • Nucleotide excision repair functions in the removal of chromium-induced DNA damage in mammalian cells. 
  • Nucleotide excision repair genes are expressed at low levels and are not detectably inducible in Caenorhabditis elegans somatic tissues, but their function is required for normal adult life after UVC exposure 
  • Nucleotide-promoted release of hMutSalpha from heteroduplex DNA is consistent with an ATP-dependent translocation mechanism. 
  • Optimizing the substrate specificity of a group I intron ribozyme. 
  • Outcome of hematopoietic cell transplantation for DNA double-strand break repair disorders. 
  • Oval cells compensate for damage and replicative senescence of mature hepatocytes in mice with fatty liver disease. 
  • Overlapping specificities of base excision repair, nucleotide excision repair, recombination, and translesion synthesis pathways for DNA base damage in Saccharomyces cerevisiae. 
  • Oxidative DNA base damage in MCF-10A breast epithelial cells at clinically achievable concentrations of doxorubicin. 
  • Oxidative DNA damage during night shift work. 
  • Palindromic sequences in heteroduplex DNA inhibit mismatch repair in yeast. 
  • Participation of p53 protein in the cellular response to DNA damage. 
  • Patterns of heteroduplex formation associated with the initiation of meiotic recombination in the yeast Saccharomyces cerevisiae. 
  • Perspective on Oncogenic Processes at the End of the Beginning of Cancer Genomics. 
  • Poly(ADP-ribose) polymerase-1 inhibition reverses temozolomide resistance in a DNA mismatch repair-deficient malignant glioma xenograft. 
  • Polygenic model of DNA repair genetic polymorphisms in human breast cancer risk. 
  • Polymorphism of DNA ligase I and risk of lung cancer--a case-control analysis. 
  • Polymorphisms in DNA base excision repair genes ADPRT and XRCC1 and risk of lung cancer. 
  • Polymorphisms in DNA damage binding protein 2 (DDB2) and susceptibility of primary lung cancer in the Chinese: a case-control study. 
  • Polymorphisms in ERCC1 and XPF genes and risk of gastric cancer in an eastern Chinese population. 
  • Polymorphisms in excision repair cross-complementing group 4 (ERCC4) and susceptibility to primary lung cancer in a Chinese Han population. 
  • Polymorphisms in hMLH1 and risk of early-onset lung cancer in a southeast Chinese population. 
  • Polymorphisms in nucleotide excision repair genes and risk of primary prostate cancer in Chinese Han populations. 
  • Polymorphisms in the DNA repair genes XPC, XPD, and XPG and risk of cutaneous melanoma: a case-control analysis. 
  • Polymorphisms in the XPG gene and risk of gastric cancer in Chinese populations. 
  • Polymorphisms in the two helicases ERCC2/XPD and ERCC3/XPB of the transcription factor IIH complex and risk of lung cancer: a case-control analysis in a Chinese population. 
  • Polymorphisms of DNA repair gene XRCC1 in squamous cell carcinoma of the head and neck. 
  • Polymorphisms of DNA repair gene XRCC3 Thr241Met and risk of gastric cancer in a Chinese population. 
  • Polymorphisms of DNA repair genes and risk of glioma. 
  • Polymorphisms of LIG4 and XRCC4 involved in the NHEJ pathway interact to modify risk of glioma. 
  • Polymorphisms of TP53 Arg72Pro, but not p73 G4C14>A4TA4 and p21 Ser31Arg, contribute to risk of cutaneous melanoma. 
  • Polymorphisms of nucleotide excision repair genes predict melanoma survival. 
  • Polymorphisms of the DNA repair gene MGMT and risk and progression of head and neck cancer. 
  • Polymorphisms of the DNA repair gene XPD and risk of lung cancer in a Chinese population. 
  • Polymorphisms of the DNA repair gene XRCC1 and risk of gastric cancer in a Chinese population. 
  • Potentially functional polymorphisms in the ERCC2 gene and risk of esophageal squamous cell carcinoma in Chinese populations. 
  • Potentially functional polymorphisms of EXO1 and risk of lung cancer in a Chinese population: A case-control analysis. 
  • Potentially functional single nucleotide polymorphisms in the core nucleotide excision repair genes and risk of squamous cell carcinoma of the head and neck. 
  • Potentially functional variants in the core nucleotide excision repair genes predict survival in Japanese gastric cancer patients. 
  • Potentiation of bleomycin lethality by anticalmodulin drugs: a role for calmodulin in DNA repair. 
  • Preferential formation and repair of chromium-induced DNA adducts and DNA--protein crosslinks in nuclear matrix DNA. 
  • Proliferation of Double-Strand Break-Resistant Polyploid Cells Requires Drosophila FANCD2. 
  • Prospective analysis of DNA damage and repair markers of lung cancer risk from the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial. 
  • Protein phosphatase 2A-dependent dephosphorylation of replication protein A is required for the repair of DNA breaks induced by replication stress. 
  • Protein phosphatase 5 is required for ATR-mediated checkpoint activation. 
  • Quantitative PCR-based measurement of nuclear and mitochondrial DNA damage and repair in mammalian cells. 
  • Quantitative PCR-based measurement of nuclear and mitochondrial DNA damage and repair in mammalian cells. 
  • REV1 inhibitor JH-RE-06 enhances tumor cell response to chemotherapy by triggering senescence hallmarks. 
  • RNA∶DNA hybrids initiate quasi-palindrome-associated mutations in highly transcribed yeast DNA. 
  • Rad18 confers hematopoietic progenitor cell DNA damage tolerance independently of the Fanconi Anemia pathway in vivo. 
  • Radiation response genotype and risk of differentiated thyroid cancer: a case-control analysis. 
  • Rapid assessment of repair of ultraviolet DNA damage with a modified host-cell reactivation assay using a luciferase reporter gene and correlation with polymorphisms of DNA repair genes in normal human lymphocytes. 
  • Rare Germline Pathogenic Mutations of DNA Repair Genes Are Most Strongly Associated with Grade Group 5 Prostate Cancer. 
  • Reaction mechanism of human DNA repair excision nuclease. 
  • Recognition and repair of compound DNA lesions (base damage and mismatch) by human mismatch repair and excision repair systems. 
  • Recombinational Repair of Nuclease-Generated Mitotic Double-Strand Breaks with Different End Structures in Yeast. 
  • Reconstitution of human DNA repair excision nuclease in a highly defined system. 
  • Recruiting substrates to cullin 4-dependent ubiquitin ligases by DDB1. 
  • Reduced DNA repair capacity for removing tobacco carcinogen-induced DNA adducts contributes to risk of head and neck cancer but not tumor characteristics. 
  • Reduced DNA repair capacity in head and neck cancer patients. 
  • Reduced DNA repair capacity in lung cancer patients. 
  • Reduced DNA repair of benzo[a]pyrene diol epoxide-induced adducts and common XPD polymorphisms in breast cancer patients. 
  • Reduced expression levels of nucleotide excision repair genes in lung cancer: a case-control analysis. 
  • Reduced expression of hMLH1 and hGTBP/hMSH6: a risk factor for head and neck cancer. 
  • Reduced expression of hMSH2 and hMLH1 and risk of prostate cancer: a case-control study. 
  • Reduced expression of mismatch repair genes in colorectal cancer patients in Egypt. 
  • Reduced expression of mismatch repair genes measured by multiplex reverse transcription-polymerase chain reaction in human gliomas. 
  • Reduced mRNA expression of nucleotide excision repair genes in lymphocytes and risk of squamous cell carcinoma of the head and neck. 
  • Redundant exonuclease involvement in Escherichia coli methyl-directed mismatch repair. 
  • Regulation of chromatin accessibility for V(D)J recombination. 
  • Regulation of hetDNA Length during Mitotic Double-Strand Break Repair in Yeast. 
  • Regulation of mitotic homeologous recombination in yeast. Functions of mismatch repair and nucleotide excision repair genes. 
  • Regulation of p53 translation and induction after DNA damage by ribosomal protein L26 and nucleolin. 
  • Relationship of cancer and aging. 
  • Removal of N-6-methyladenine by the nucleotide excision repair pathway triggers the repair of mismatches in yeast gap-repair intermediates. 
  • Removal of frameshift intermediates by mismatch repair proteins in Saccharomyces cerevisiae. 
  • Repair capacity for UV light induced DNA damage associated with risk of nonmelanoma skin cancer and tumor progression. 
  • Repair of DNA loops involves DNA-mismatch and nucleotide-excision repair proteins. 
  • Repair of UV light-induced DNA damage and risk of cutaneous malignant melanoma. 
  • Repair of double-strand breaks in bacteriophage T4 by a mechanism that involves extensive DNA replication. 
  • Repair of large insertion/deletion heterologies in human nuclear extracts is directed by a 5' single-strand break and is independent of the mismatch repair system. 
  • Repair of mitomycin C cross-linked DNA in mammalian cells measured by a host cell reactivation assay. 
  • Repair of specific base pair mismatches formed during meiotic recombination in the yeast Saccharomyces cerevisiae. 
  • Repair of the Escherichia coli chromosome after in vivo scission by the EcoRI endonuclease. 
  • Repair of tobacco carcinogen-induced DNA adducts and lung cancer risk: a molecular epidemiologic study. 
  • Repair of topoisomerase-mediated DNA damage in bacteriophage T4. 
  • Requirement for d(GATC) sequences in Escherichia coli mutHLS mismatch correction. 
  • Restoration of mismatch repair to nuclear extracts of H6 colorectal tumor cells by a heterodimer of human MutL homologs. 
  • Retargeting mobile group II introns to repair mutant genes. 
  • Rev7 loss alters cisplatin response and increases drug efficacy in chemotherapy-resistant lung cancer. 
  • Role of Escherichia coli DNA polymerase I in conferring viability upon the dnaN159 mutant strain. 
  • Role of mismatch repair in the fidelity of RAD51- and RAD59-dependent recombination in Saccharomyces cerevisiae. 
  • Role of recombinational repair in sensitivity to an antitumour agent that inhibits bacteriophage T4 type II DNA topoisomerase. 
  • Roles of ATM and NBS1 in chromatin structure modulation and DNA double-strand break repair. 
  • Roles of RAD6 epistasis group members in spontaneous polzeta-dependent translesion synthesis in Saccharomyces cerevisiae. 
  • Roles of exonucleases and translesion synthesis DNA polymerases during mitotic gap repair in yeast. 
  • Saccharomyces cerevisiae Ntg1p and Ntg2p: broad specificity N-glycosylases for the repair of oxidative DNA damage in the nucleus and mitochondria. 
  • Saccharomyces cerevisiae RAD5-encoded DNA repair protein contains DNA helicase and zinc-binding sequence motifs and affects the stability of simple repetitive sequences in the genome. 
  • Salicylic acid activates DNA damage responses to potentiate plant immunity. 
  • Sample size for biomarker studies: more subjects or more measurements per subject? 
  • Selected polymorphisms of DNA repair genes and risk of pancreatic cancer. 
  • Self-assembled Lipid Nanoparticles for Ratiometric Codelivery of Cisplatin and siRNA Targeting XPF to Combat Drug Resistance in Lung Cancer. 
  • Sensitivity to DNA damage induced by benzo(a)pyrene diol epoxide and risk of lung cancer: a case-control analysis. 
  • Sequence composition and context effects on the generation and repair of frameshift intermediates in mononucleotide runs in Saccharomyces cerevisiae. 
  • Sequence divergence impedes crossover more than noncrossover events during mitotic gap repair in yeast. 
  • Sequence variations in DNA repair gene XPC is associated with lung cancer risk in a Chinese population: a case-control study. 
  • Significant effect of homologous recombination DNA repair gene polymorphisms on pancreatic cancer survival. 
  • Simultaneous amplification of four DNA repair genes and beta-actin in human lymphocytes by multiplex reverse transcriptase-PCR. 
  • Single nucleotide polymorphisms of RecQ1, RAD54L, and ATM genes are associated with reduced survival of pancreatic cancer. 
  • Single-cell microarray enables high-throughput evaluation of DNA double-strand breaks and DNA repair inhibitors. 
  • Site-specific methylases induce the SOS DNA repair response in Escherichia coli. 
  • Skin-resident T cells sense ultraviolet radiation-induced injury and contribute to DNA repair. 
  • Small ubiquitin-like modifier 1-3 conjugation [corrected] is activated in human astrocytic brain tumors and is required for glioblastoma cell survival. 
  • Small-molecule targeted therapies induce dependence on DNA double-strand break repair in residual tumor cells. 
  • Smoking, DNA repair capacity and risk of nonsmall cell lung cancer. 
  • Somatic mutation of hPMS2 as a possible cause of sporadic human colon cancer with microsatellite instability. 
  • Some properties of a DNA-unwinding protein unique to lymphocytes from chronic lymphocytic leukemia. 
  • Spatial organization of the mammalian genome surveillance machinery in response to DNA strand breaks. 
  • Spontaneous frameshift mutations in Saccharomyces cerevisiae: accumulation during DNA replication and removal by proofreading and mismatch repair activities. 
  • Stabilization of microsatellite sequences by variant repeats in the yeast Saccharomyces cerevisiae. 
  • Stacking the DEK: from chromatin topology to cancer stem cells. 
  • Staphylococcus aureus sepsis and mitochondrial accrual of the 8-oxoguanine DNA glycosylase DNA repair enzyme in mice. 
  • Staphylococcus aureus sepsis induces early renal mitochondrial DNA repair and mitochondrial biogenesis in mice. 
  • Strand-specific mismatch correction in nuclear extracts of human and Drosophila melanogaster cell lines. 
  • Strand-specific mismatch repair in mammalian cells. 
  • Structure of the Rad50 x Mre11 DNA repair complex from Saccharomyces cerevisiae by electron microscopy. 
  • Substrate spectrum of human excinuclease: repair of abasic sites, methylated bases, mismatches, and bulky adducts. 
  • Suppression of isoprenylcysteine carboxylmethyltransferase compromises DNA damage repair. 
  • Synergistic interaction between anti-p185HER-2 ricin A chain immunotoxins and radionuclide conjugates for inhibiting growth of ovarian and breast cancer cells that overexpress HER-2. 
  • THZ531 Induces a State of BRCAness in Multiple Myeloma Cells: Synthetic Lethality with Combination Treatment of THZ 531 with DNA Repair Inhibitors. 
  • Tagging SNPs in non-homologous end-joining pathway genes and risk of glioma. 
  • Tagging single nucleotide polymorphisms in excision repair cross-complementing group 1 (ERCC1) and risk of primary lung cancer in a Chinese population. 
  • Targeting Androgen Receptor and DNA Repair in Metastatic Castration-Resistant Prostate Cancer: Results From NCI 9012. 
  • Targeting the ATM Kinase to Enhance the Efficacy of Radiotherapy and Outcomes for Cancer Patients. 
  • Temperature-sensitive mutants of the EcoRI endonuclease. 
  • The "Inside" Story on Tumor-Expressed PD-L1. 
  • The 9-1-1 checkpoint clamp physically interacts with polzeta and is partially required for spontaneous polzeta-dependent mutagenesis in Saccharomyces cerevisiae. 
  • The ATM-dependent DNA damage signaling pathway. 
  • The C-terminal domain of the adenine-DNA glycosylase MutY confers specificity for 8-oxoguanine.adenine mispairs and may have evolved from MutT, an 8-oxo-dGTPase. 
  • The DNA damage response: implications for tumor responses to radiation and chemotherapy. 
  • The DNA helicase activities of Rad3 protein of Saccharomyces cerevisiae and helicase II of Escherichia coli are differentially inhibited by covalent and noncovalent DNA modifications. 
  • The DNA repair protein, O(6)-methylguanine-DNA methyltransferase is a proteolytic target for the E6 human papillomavirus oncoprotein. 
  • The GO system prevents ROS-induced mutagenesis and killing in Pseudomonas aeruginosa. 
  • The Molecular Taxonomy of Primary Prostate Cancer. 
  • The MutL ATPase is required for mismatch repair. 
  • The N2-ethylguanine and the O6-ethyl- and O6-methylguanine lesions in DNA: contrasting responses from the "bypass" DNA polymerase eta and the replicative DNA polymerase alpha. 
  • The QPCR assay for analysis of mitochondrial DNA damage, repair, and relative copy number. 
  • The adenovirus E4orf6 protein inhibits DNA double strand break repair and radiosensitizes human tumor cells in an E1B-55K-independent manner. 
  • The beta sliding clamp binds to multiple sites within MutL and MutS. 
  • The bromodomain protein Brd4 insulates chromatin from DNA damage signalling. 
  • The compact chromatin structure of a Ty repeated sequence suppresses recombination hotspot activity in Saccharomyces cerevisiae. 
  • The effect of oxidative metabolism on spontaneous Pol zeta-dependent translesion synthesis in Saccharomyces cerevisiae. 
  • The fidelity of DNA replication, particularly on GC-rich templates, is reduced by defects of the Fe-S cluster in DNA polymerase δ. 
  • The folate cofactor of Escherichia coli DNA photolyase acts catalytically. 
  • The genome's best friend. 
  • The in vivo characterization of translesion synthesis across UV-induced lesions in Saccharomyces cerevisiae: insights into Pol zeta- and Pol eta-dependent frameshift mutagenesis. 
  • The many substrates and functions of ATM. 
  • The mechanism of nucleotide excision repair-mediated UV-induced mutagenesis in nonproliferating cells. 
  • The mismatch DNA repair heterodimer, hMSH2/6, regulates BLM helicase. 
  • The origin of O6-methylguanine-DNA methyltransferase in Chinese hamster ovary cells transfected with human DNA. 
  • The other function of DNA photolyase: stimulation of excision repair of chemical damage to DNA. 
  • The phage T4 protein UvsW drives Holliday junction branch migration. 
  • The role of DNA repair capacity in susceptibility to lung cancer: a review. 
  • The role of Dbf4-dependent protein kinase in DNA polymerase ζ-dependent mutagenesis in Saccharomyces cerevisiae. 
  • The role of the mismatch repair machinery in regulating mitotic and meiotic recombination between diverged sequences in yeast. 
  • The scaffold protein WRAP53β orchestrates the ubiquitin response critical for DNA double-strand break repair. 
  • The specificity of topoisomerase-mediated DNA cleavage defines acridine-induced frameshift specificity within a hotspot in bacteriophage T4. 
  • The stabilization of repetitive tracts of DNA by variant repeats requires a functional DNA mismatch repair system. 
  • The tight linkage between DNA replication and double-strand break repair in bacteriophage T4. 
  • The yeast HSM3 gene is not involved in DNA mismatch repair in rapidly dividing cells. 
  • There is substantial agreement among interspecies estimates of DNA repair activity. 
  • Tn5-mediated bleomycin resistance in Escherichia coli requires the expression of host genes. 
  • Topoisomerase 1-dependent deletions initiated by incision at ribonucleotides are biased to the non-transcribed strand of a highly activated reporter. 
  • Topoisomerase II inhibition and altered kinetics of formation and repair of nitrosourea and cisplatin-induced DNA interstrand cross-links and cytotoxicity in human glioblastoma cells. 
  • Towards precision prevention: Technologies for identifying healthy individuals with high risk of disease. 
  • Transcription as a source of genome instability. 
  • Transcription-associated mutagenesis in yeast is directly proportional to the level of gene expression and influenced by the direction of DNA replication. 
  • Transcriptional inhibition by carcinogenic chromate: relationship to DNA damage. 
  • Transposon Tn5: specific sequence recognition and conservative transposition. 
  • Triplet repeats form secondary structures that escape DNA repair in yeast. 
  • Ubiquitin recognition by FAAP20 expands the complex interface beyond the canonical UBZ domain. 
  • V(D)J hypermutation and DNA mismatch repair: vexed by fixation. 
  • Variants in Notch signalling pathway genes, PSEN1 and MAML2, predict overall survival in Chinese patients with epithelial ovarian cancer. 
  • Variants in nucleotide excision repair core genes and susceptibility to recurrence of squamous cell carcinoma of the oropharynx. 
  • Variation in efficiency of DNA mismatch repair at different sites in the yeast genome. 
  • Variation within DNA repair pathway genes and risk of multiple sclerosis. 
  • Vitamin supplementation and reduced risk of basal cell carcinoma. 
  • WNT inhibition creates a BRCA-like state in Wnt-addicted cancer. 
  • Whole-genome analysis informs breast cancer response to aromatase inhibition. 
  • Wnt Signaling and Drug Resistance in Cancer. 
  • XPA polymorphism associated with reduced lung cancer risk and a modulating effect on nucleotide excision repair capacity. 
  • Yeast base excision repair: interconnections and networks. 
  • ZTF-8 interacts with the 9-1-1 complex and is required for DNA damage response and double-strand break repair in the C. elegans germline. 
  • Zebrafish CYP1A expression in transgenic Caenorhabditis elegans protects from exposures to benzo[a]pyrene and a complex polycyclic aromatic hydrocarbon mixture. 
  • p53 functional impairment and high p21waf1/cip1 expression in human T-cell lymphotropic/leukemia virus type I-transformed T cells. 
  • α-synucleinopathy exerts sex-dimorphic effects on the multipurpose DNA repair/redox protein APE1 in mice and humans. 
  • βarrestin-1 regulates DNA repair by acting as an E3-ubiquitin ligase adaptor for 53BP1. 
• 

  Keywords of People

  • Abbruzzese, James, D. C. I. Distinguished Professor of Medical Oncology, Medicine, Medical Oncology
  • Berchuck, Andrew, James M. Ingram Distinguished Professor of Gynecologic Oncology, Obstetrics and Gynecology, Gynecologic Oncology
  • Clyde, Merlise, Professor of Statistical Science, Statistical Science
  • Erickson, Harold Paul, James B. Duke Distinguished Professor Emeritus, Cell Biology
  • Halabi, Susan, Professor of Biostatistics & Bioinformatics, Biostatistics & Bioinformatics
  • Jinks-Robertson, Sue, James B. Duke Distinguished Professor of Molecular Genetics and Microbiology, Cell Biology
  • Kelsoe, Garnett H., James B. Duke Distinguished Professor of Immunology, Integrative Immunobiology
  • Krangel, Michael S., George Barth Geller Distinguished Professor of Immunology, Integrative Immunobiology
  • McLendon, Roger Edwin, Professor of Pathology, Pathology
  • Moorman, Patricia Gripka, Professor Emeritus in Family Medicine and Community Health, Duke Cancer Institute
  • Sullivan, Beth Ann, Professor of Molecular Genetics and Microbiology, Duke Science & Society