DNA Replication

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  Subject Areas on Research

  • 1,10-Phenanthroline reversibility inhibits proliferation of two human prostate carcinoma cell lines (PC-3 and DU145). 
  • 2',3'-dideoxy-beta-L-5-fluorocytidine inhibits duck hepatitis B virus reverse transcription and suppresses viral DNA synthesis in hepatocytes, both in vitro and in vivo. 
  • 5-Azacytidine induced methyltransferase-DNA adducts block DNA replication in vivo. 
  • A 'Semi-Protected Oligonucleotide Recombination' Assay for DNA Mismatch Repair in vivo Suggests Different Modes of Repair for Lagging Strand Mismatches. 
  • A 57,000-mol-wt protein uniquely present in nonproliferating cells and senescent human fibroblasts. 
  • A Bacterial Chromosome Structuring Protein Binds Overtwisted DNA to Stimulate Type II Topoisomerases and Enable DNA Replication. 
  • A CDC6 protein-binding peptide selected using a bacterial two-hybrid-like system is a cell cycle inhibitor. 
  • A G-quadruplex DNA-affinity Approach for Purification of Enzymatically Active G4 Resolvase1. 
  • A cell-nonautonomous mechanism of yeast chronological aging regulated by caloric restriction and one-carbon metabolism. 
  • A conserved region at the COOH terminus of human immunodeficiency virus gp120 envelope protein contains an immunodominant epitope. 
  • A defective phage system reveals bacteriophage T4 replication origins that coincide with recombination hot spots. 
  • A deletion-generator compound element allows deletion saturation analysis for genomewide phenotypic annotation. 
  • A dimerized coiled-coil domain and an adjoining part of geminin interact with two sites on Cdt1 for replication inhibition. 
  • A festival of cell-cycle controls. 
  • A genomic view of eukaryotic DNA replication. 
  • A human protein related to yeast Cdc6p. 
  • A new assay to quantify in vivo repair of G:T mispairs by base excision repair. 
  • A novel structural form of the 2 micron plasmid of the yeast Saccharomyces cerevisiae. 
  • A novel, non-apoptotic role for Scythe/BAT3: a functional switch between the pro- and anti-proliferative roles of p21 during the cell cycle. 
  • ATM Regulation of the Cohesin Complex Is Required for Repression of DNA Replication and Transcription in the Vicinity of DNA Double-Strand Breaks. 
  • Activation of SV40 DNA replication in vitro by cellular protein phosphatase 2A. 
  • Adrenergic control of DNA synthesis in developing rat brain regions: effects of intracisternal administration of isoproterenol. 
  • Alleles of the yeast Pms1 mismatch-repair gene that differentially affect recombination- and replication-related processes. 
  • Alpha 2-adrenergic agonists stimulate DNA synthesis in Chinese hamster lung fibroblasts transfected with a human alpha 2-adrenergic receptor gene. 
  • Altered rate of DNA replication in ageing human fibroblast cultures. 
  • Amelioration strategies fail to prevent tobacco smoke effects on neurodifferentiation: Nicotinic receptor blockade, antioxidants, methyl donors. 
  • An Atlas of Genetic Variation Linking Pathogen-Induced Cellular Traits to Human Disease. 
  • An analysis of single nucleotide polymorphisms of 125 DNA repair genes in the Texas genome-wide association study of lung cancer with a replication for the XRCC4 SNPs. 
  • An antitumor drug-induced topoisomerase cleavage complex blocks a bacteriophage T4 replication fork in vivo. 
  • Analysis of APOBEC-induced mutations in yeast strains with low levels of replicative DNA polymerases. 
  • Analysis of Cdc6 function in the assembly of mammalian prereplication complexes. 
  • Analysis of the cell cycle using Xenopus egg extracts. 
  • Analysis of the individual regulatory components of the IncFII plasmid replication control system. 
  • Antimitotic and cytotoxic effects of theophylline in MDA-MB-231 human breast cancer cells. 
  • Antiviral activity of mismatched double-stranded RNA against human immunodeficiency virus in vitro. 
  • Arrest of replication by mammalian DNA polymerases alpha and beta caused by chromium-DNA lesions. 
  • Autocrine stimulation of mas oncogene leads to altered growth control. 
  • BRD4 Prevents R-Loop Formation and Transcription-Replication Conflicts by Ensuring Efficient Transcription Elongation. 
  • Bacteriophage T4 gene 41 helicase and gene 59 helicase-loading protein: a versatile couple with roles in replication and recombination. 
  • Bacteriophage T4 initiates bidirectional DNA replication through a two-step process. 
  • Bacteriophage T4 proteins replicate plasmids with a preformed R loop at the T4 ori(uvsY) replication origin in vitro. 
  • Bacteriophage T7 Deoxyribonucleic acid replication in vitro. A protein of Escherichia coli required for bacteriophage T7 DNA polymerase activity. 
  • Bacteriophage T7 deoxyribonucleic acid replication invitro. Bacteriophage T7 DNA polymerase: an an emzyme composed of phage- and host-specific subunits. 
  • Barriers to productive transfection of trabecular meshwork cells. 
  • Base composition of mononucleotide runs affects DNA polymerase slippage and removal of frameshift intermediates by mismatch repair in Saccharomyces cerevisiae. 
  • Base-specific arrest of in vitro DNA replication by carcinogenic chromium: relationship to DNA interstrand crosslinking. 
  • Beta adrenergic control of macromolecule synthesis in neonatal rat heart, kidney and lung: relationship to sympathetic neuronal development. 
  • Binding of receptor-recognized forms of alpha2-macroglobulin to the alpha2-macroglobulin signaling receptor activates phosphatidylinositol 3-kinase. 
  • CD10/neutral endopeptidase 24.11 hydrolyzes bombesin-like peptides and regulates the growth of small cell carcinomas of the lung. 
  • CD10/neutral endopeptidase 24.11 regulates fetal lung growth and maturation in utero by potentiating endogenous bombesin-like peptides. 
  • Cadmium-induced DNA synthesis and cell proliferation in macrophages: the role of intracellular calcium and signal transduction mechanisms. 
  • Calmodulin and the cell cycle: involvement in regulation of cell-cycle progression. 
  • Carcinogenesis in urogenital sites. 
  • Cdc6 is regulated by E2F and is essential for DNA replication in mammalian cells. 
  • Cell cycle progression in G1 and S phases is CCR4 dependent following ionizing radiation or replication stress in Saccharomyces cerevisiae. 
  • Cell cycle. Checking two steps. 
  • Cell cycle: Flies teach an old dogma new tricks. 
  • Cell-Cycle-Dependent Chromatin Dynamics at Replication Origins. 
  • Centromere identity in Drosophila is not determined in vivo by replication timing. 
  • Characterization of a defective phage system for the analysis of bacteriophage T4 DNA replication origins. 
  • Characterization of the repeat-tract instability and mutator phenotypes conferred by a Tn3 insertion in RFC1, the large subunit of the yeast clamp loader. 
  • Checkpoints couple transcription network oscillator dynamics to cell-cycle progression. 
  • Chemically induced mutations observed as mosaics in Drosophila melanogaster. 
  • Chromatin and DNA replication. 
  • Chromatin signatures of the Drosophila replication program. 
  • Chromosomal translocations in yeast induced by low levels of DNA polymerase a model for chromosome fragile sites. 
  • Chromosome aberrations resulting from double-strand DNA breaks at a naturally occurring yeast fragile site composed of inverted ty elements are independent of Mre11p and Sae2p. 
  • Chromosome fragility at GAA tracts in yeast depends on repeat orientation and requires mismatch repair. 
  • Chromosome rearrangements via template switching between diverged repeated sequences. 
  • Co-orientation of replication and transcription preserves genome integrity. 
  • Combination therapy of inhibitors of epidermal growth factor receptor/vascular endothelial growth factor receptor 2 (AEE788) and the mammalian target of rapamycin (RAD001) offers improved glioblastoma tumor growth inhibition. 
  • Comparative analysis of metazoan chromatin organization. 
  • Comparison of in vitro and in vivo differentiation of myeloblastic leukemia of the RFM/Un mouse. 
  • Complexities of chromium carcinogenesis: role of cellular response, repair and recovery mechanisms. 
  • Constrained four parameter logistic model. 
  • Contributions of Mamu-A*01 status and TRIM5 allele expression, but not CCL3L copy number variation, to the control of SIVmac251 replication in Indian-origin rhesus monkeys. 
  • Control of G1 arrest after DNA damage. 
  • Control of simian virus 40 DNA replication by the HeLa cell nuclear kinase casein kinase I. 
  • Coordination and processing of DNA ends during double-strand break repair: the role of the bacteriophage T4 Mre11/Rad50 (MR) complex. 
  • Coordination of replication and transcription along a Drosophila chromosome. 
  • Copper-dependent site-specific mutagenesis by benzoyl peroxide in the supF gene of the mutation reporter plasmid pS189. 
  • Culture kinetics of glycolytic enzyme induction, glucose utilization, and thymidine incorporation of extended-exposure phytohemagglutinin-stimulated human lymphocytes. 
  • Cyclosporin A inhibits inositol 1,4,5-trisphosphate binding to its receptors and release of calcium from intracellular stores in peritoneal macrophages. 
  • Cytological evidence of transcription of highly repeated DNA sequences during the lampbrush stage in Triturus cristatus carnifex. 
  • DNA Sequence Recognition by DNA Primase Using High-Throughput Primase Profiling. 
  • DNA bending near the replication origin of IncFII plasmid NR1. 
  • DNA damage responses in prokaryotes: regulating gene expression, modulating growth patterns, and manipulating replication forks. 
  • DNA mismatch correction. 
  • DNA repair capacity in healthy medical students during and after exam stress. 
  • DNA repair synthesis in isolated rainbow trout liver cells. 
  • DNA replication and progression through the cell cycle. 
  • DNA replication and transcription programs respond to the same chromatin cues. 
  • DNA replication checkpoint control of Wee1 stability by vertebrate Hsl7. 
  • DNA replication origins-where do we begin? 
  • DNA replication. 
  • Defining origins of replication in mammalian cells. 
  • Defining the replication program through the chromatin landscape. 
  • Deletions associated with stabilization of the Top1 cleavage complex in yeast are products of the nonhomologous end-joining pathway. 
  • Delineating the requirements for spontaneous DNA damage resistance pathways in genome maintenance and viability in Saccharomyces cerevisiae. 
  • Destabilization of tracts of simple repetitive DNA in yeast by mutations affecting DNA mismatch repair. 
  • Detection of DNA looping due to simultaneous interaction of a DNA-binding protein with two spatially separated binding sites on DNA. 
  • Developmental control of gene copy number by repression of replication initiation and fork progression. 
  • Developmental control of the DNA replication and transcription programs. 
  • Developmental neurotoxicity of chlorpyrifos: delayed targeting of DNA synthesis after repeated administration. 
  • Developmental regulation of DNA replication: replication fork barriers and programmed gene amplification in Tetrahymena thermophila. 
  • Different oligomeric forms of protein phosphatase 2A activate and inhibit simian virus 40 DNA replication. 
  • Differential effects of epidermal growth factor, somatomedin-C/insulin-like growth factor I, and transforming growth factor-beta on porcine granulosa cell deoxyribonucleic acid synthesis and cell proliferation. 
  • Differential expression of mitochondrial DNA replication factors in mammalian tissues. 
  • Differential impact of ionic and coordinate covalent chromium (Cr)-DNA binding on DNA replication. 
  • Differential replication of ribosomal gene repeats in polytene nuclei of Drosophila. 
  • Differential replication of satellite DNA in polyploid tissues of Drosophila virilis. 
  • Differential susceptibility of yeast S and M phase CDK complexes to inhibitory tyrosine phosphorylation. 
  • Diffusible factors are responsible for differences in nuclease sensitivity among chromatins originating from different cell types. 
  • Diminished capacity for p53 in mediating a radiation-induced G1 arrest in established human tumor cell lines. 
  • Disruption of origin chromatin structure by helicase activation in the absence of DNA replication. 
  • Disruption of the Rad9/Rad1/Hus1 (9-1-1) complex leads to checkpoint signaling and replication defects. 
  • Dissecting the differences between the alpha and beta anomers of the oxidative DNA lesion FaPydG. 
  • Distinctions in the specificity of E2F function revealed by gene expression signatures. 
  • Diverse hypermutability of multiple expressed sequence motifs present in a cancer with microsatellite instability. 
  • Do genetic make-up and growth manipulation affect tomato fruit size by cell number, or cell size and DNA endoreduplication? 
  • Double-strand break repair in tandem repeats during bacteriophage T4 infection. 
  • Drosophila E2f2 promotes the conversion from genomic DNA replication to gene amplification in ovarian follicle cells. 
  • Drosophila follicle cell amplicons as models for metazoan DNA replication: a cyclinE mutant exhibits increased replication fork elongation. 
  • Drosophila homologue of the Rothmund-Thomson syndrome gene: essential function in DNA replication during development. 
  • Dual control of DNA synthesis by alpha- and beta-adrenergic mechanisms in normoxic and hypoxic neonatal rat brain. 
  • Duplication of single stranded DNA catalyzed by calf thymus DNA polymerase alpha. 
  • Dynamic basis for dG•dT misincorporation via tautomerization and ionization. 
  • Dynamics of BAF-Polycomb complex opposition on heterochromatin in normal and oncogenic states. 
  • E2F3 activity is regulated during the cell cycle and is required for the induction of S phase. 
  • Early activation and cell cycle entry of resting B cells after Fab-anti-Ig treatment: role of receptor crosslinking. 
  • Early intracellular events in the replication of bacteriophage T4 deoxyribonucleic acid. VI. Newly synthesized proteins in the T4 protein-deoxyribonucleic acid complex. 
  • Effect of nickel(II) on DNA-protein binding, thymidine incorporation, and sedimentation pattern of chromatin fractions from intact mammalian cells. 
  • Effect of thimerosal in leukemia, in leukemic cell lines, and on normal hematopoiesis. 
  • Effects of 5'-fluoro-2-deoxyuridine on mitochondrial biology in Caenorhabditis elegans. 
  • Effects of glutathione on chromium-induced DNA crosslinking and DNA polymerase arrest. 
  • Elevated Genome-Wide Instability in Yeast Mutants Lacking RNase H Activity. 
  • Emerging antiviral therapeutics for human adenovirus infection: Recent developments and novel strategies. 
  • Endonuclease-independent DNA mismatch repair processes on the lagging strand. 
  • Endothelin-1 induces an increase in total protein synthesis and expression of the smooth muscle alpha-actin gene in vascular smooth muscle cells. 
  • Enhancer-origin interaction in plasmid R6K involves a DNA loop mediated by initiator protein. 
  • Epidermal growth factor replaces estrogen in the stimulation of female genital-tract growth and differentiation. 
  • Error-prone replication of oxidatively damaged DNA by a high-fidelity DNA polymerase. 
  • Evidence for Compartmentalized Axonal Mitochondrial Biogenesis: Mitochondrial DNA Replication Increases in Distal Axons As an Early Response to Parkinson's Disease-Relevant Stress. 
  • Evidence for a dual role for TC4 protein in regulating nuclear structure and cell cycle progression. 
  • Evidence for a pro-proliferative feedback loop in prostate cancer: the role of Epac1 and COX-2-dependent pathways. 
  • Evidence that a free-running oscillator drives G1 events in the budding yeast cell cycle. 
  • Expression and function of the uvsW gene of bacteriophage T4. 
  • Expression of the E2F1 transcription factor overcomes type beta transforming growth factor-mediated growth suppression. 
  • Extracellular Matrix Degradation Products Downregulate Neoplastic Esophageal Cell Phenotype. 
  • Fiber autoradiography of replicating yeast DNA. 
  • Flavivirus RNA transactions from viral entry to genome replication. 
  • Following an environmental carcinogen N2-dG adduct through replication: elucidating blockage and bypass in a high-fidelity DNA polymerase. 
  • Fork regression is an active helicase-driven pathway in bacteriophage T4. 
  • Formation and processing of stalled replication forks--utility of two-dimensional agarose gels. 
  • Frameshift intermediates in homopolymer runs are removed efficiently by yeast mismatch repair proteins. 
  • Frameshift mutagenesis: the roles of primer-template misalignment and the nonhomologous end-joining pathway in Saccharomyces cerevisiae. 
  • Friedreich's ataxia (GAA)n•(TTC)n repeats strongly stimulate mitotic crossovers in Saccharomyces cerevisae. 
  • Functions of fission yeast orp2 in DNA replication and checkpoint control. 
  • Functions that Protect Escherichia coli from Tightly Bound DNA-Protein Complexes Created by Mutant EcoRII Methyltransferase. 
  • Fusion of the termini of the murine cytomegalovirus genome after infection. 
  • Gap formation is associated with methyl-directed mismatch correction under conditions of restricted DNA synthesis. 
  • Genetic and enzymatic characterization of a conditional lethal mutant of Escherichia coli K12 with a temperature-sensitive DNA ligase. 
  • Genetic control of chromosome length in yeast. 
  • Genome-wide analysis of genomic alterations induced by oxidative DNA damage in yeast. 
  • Genome-wide analysis of re-replication reveals inhibitory controls that target multiple stages of replication initiation. 
  • Genome-wide association study of white blood cell count in 16,388 African Americans: the continental origins and genetic epidemiology network (COGENT). 
  • Genome-wide high-resolution mapping of UV-induced mitotic recombination events in Saccharomyces cerevisiae. 
  • Genome-wide linkage scan for prostate cancer aggressiveness loci using families from the University of Michigan Prostate Cancer Genetics Project. 
  • Genome-wide localization of replication factors. 
  • Genomic FHIT analysis in RER+ and RER- adenocarcinomas of the pancreas. 
  • Global analysis of genomic instability caused by DNA replication stress in Saccharomyces cerevisiae. 
  • Global genomic instability caused by reduced expression of DNA polymerase ε in yeast. 
  • Hereditary nonpolyposis colorectal cancer: preventive management. 
  • Herpesviruses carrying a Brainbow cassette reveal replication and expression of limited numbers of incoming genomes. 
  • Heterogeneous polymerase fidelity and mismatch repair bias genome variation and composition. 
  • High-Frequency Illegitimate Strand Transfers of Nascent DNA Fragments During Reverse Transcription Result in Defective Retrovirus Genomes. 
  • High-Resolution Mapping of Homologous Recombination Events in rad3 Hyper-Recombination Mutants in Yeast. 
  • Homologous Recombination and Translesion DNA Synthesis Play Critical Roles on Tolerating DNA Damage Caused by Trace Levels of Hexavalent Chromium. 
  • Human Rad9 is required for the activation of S-phase checkpoint and the maintenance of chromosomal stability. 
  • Human T-cell leukemia virus type 1 tax attenuates the ATM-mediated cellular DNA damage response. 
  • Human immunodeficiency virus type 1 Vpr-binding protein VprBP, a WD40 protein associated with the DDB1-CUL4 E3 ubiquitin ligase, is essential for DNA replication and embryonic development. 
  • Human mitochondrial DNA polymerase gamma exhibits potential for bypass and mutagenesis at UV-induced cyclobutane thymine dimers 
  • Human origin recognition complex large subunit is degraded by ubiquitin-mediated proteolysis after initiation of DNA replication. 
  • Human papillomavirus 16 E6 expression disrupts the p53-mediated cellular response to DNA damage. 
  • Human protein phosphatase PP6 regulatory subunits provide Sit4-dependent and rapamycin-sensitive sap function in Saccharomyces cerevisiae. 
  • Hyalocytes synthesize and secrete inhibitors of retinal pigment epithelial cell proliferation in vitro. 
  • Hydrolysis of template and newly synthesized deoxyribonucleic acid by the 3' to 5' exonuclease activity of the T4 deoxyribonucleic acid polymerase. 
  • Hypermutability and mismatch repair deficiency in RER+ tumor cells. 
  • Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project. 
  • Identification of a mutant DNA polymerase delta in Saccharomyces cerevisiae with an antimutator phenotype for frameshift mutations. 
  • Identification of a strand-related bias in the PCNA-mediated bypass of spontaneous lesions by yeast Poleta. 
  • Identification of cellular proteins required for simian virus 40 DNA replication. 
  • Identification of inhibitory autophosphorylation sites in casein kinase I epsilon. 
  • Identification of the nuclear localization signal in Xenopus cyclin E and analysis of its role in replication and mitosis. 
  • Identification of yeast mutants with altered telomere structure. 
  • Immune status assay (ISA): a noninvasive procedure for studying allograft rejection. 
  • Improved EBV shuttle vectors. 
  • In vitro cell cycle arrest induced by using artificial DNA templates. 
  • In vitro neurogenesis by neuronal precursor cells derived from the adult songbird brain. 
  • In vivo mutagenesis of the reporter plasmid pSP189 induced by exposure of host Ad293 cells to activated polymorphonuclear leukocytes. 
  • In vivo production of an RNA-DNA copolymer after infection of Escherichia coli by bacteriophage T4. 
  • IncFII plasmid incompatibility product and its target are both RNA transcripts. 
  • Incompatibility and IncFII plasmid replication control. 
  • Induction of rat kidney ornithine decarboxylase by nicotinamide without a concomitant increase in DNA synthesis. 
  • Inhibition of DNA replication by tirapazamine. 
  • Inhibition of cultured human RPE cell proliferation and lysyl hydroxylase activity by hydroxy derivatives of minoxidil. 
  • Inhibition of human corneal epithelium with immunotoxin 454A12-rRA. 
  • Inhibition of mitogen-activated protein kinase and phosphatidylinositol 3-kinase activity in MCF-7 cells prevents estrogen-induced mitogenesis. 
  • Initiating cellular stress responses. 
  • Initiation of SV40 DNA replication: mechanism and control. 
  • Initiation of bacteriophage T4 DNA replication and replication fork dynamics: a review in the Virology Journal series on bacteriophage T4 and its relatives. 
  • Initiation of replication at a mammalian chromosomal origin. 
  • Innate and adaptive receptors interact to balance humoral immunity. 
  • Interactions of human nucleotide excision repair protein XPA with DNA and RPA70 Delta C327: chemical shift mapping and 15N NMR relaxation studies. 
  • Interplay between DNA replication and recombination in prokaryotes. 
  • Intrachromosomal gene conversion and the maintenance of sequence homogeneity among repeated genes. 
  • Intragenic regulation of the synthesis of phi chi 174 gene A proteins. 
  • Inverted DNA repeats channel repair of distant double-strand breaks into chromatid fusions and chromosomal rearrangements. 
  • Involvement of two endonuclease III homologs in the base excision repair pathway for the processing of DNA alkylation damage in Saccharomyces cerevisiae. 
  • Isolation and characterization of the replicon of a Thiobacillus intermedius plasmid. 
  • Isolation of SOS constitutive mutants of Escherichia coli. 
  • Isolation of human sequences that replicate autonomously in human cells. 
  • Lack of genomic imprinting of DNA primase, polypeptide 2 (PRIM2) in human term placenta and white blood cells. 
  • Lactoferrin expression in the mouse reproductive tract during the natural estrous cycle: correlation with circulating estradiol and progesterone. 
  • Local nucleosome dynamics and eviction following a double-strand break are reversible by NHEJ-mediated repair in the absence of DNA replication. 
  • MDM2 antagonists overcome intrinsic resistance to CDK4/6 inhibition by inducing p21. 
  • Mcm10 and And-1/CTF4 recruit DNA polymerase alpha to chromatin for initiation of DNA replication. 
  • Mcm2-7 Is an Active Player in the DNA Replication Checkpoint Signaling Cascade via Proposed Modulation of Its DNA Gate. 
  • Mechanism by which T7 bacteriophage protein Gp1.2 inhibits Escherichia coli dGTPase. 
  • Mechanism of action of nalidixic acid: purification of Escherichia coli nalA gene product and its relationship to DNA gyrase and a novel nicking-closing enzyme. 
  • Mechanism of activation of simian virus 40 DNA replication by protein phosphatase 2A. 
  • Mechanisms and biological effects of mismatch repair. 
  • Membrane localization of the kinase which phosphorylates p34cdc2 on threonine 14. 
  • Metabolic stress is a barrier to Epstein-Barr virus-mediated B-cell immortalization. 
  • Method for the structural analysis of Twinkle mitochondrial DNA helicase by cryo-EM. 
  • Methylation of deoxycytidine incorporated by excision-repair synthesis of DNA. 
  • Methylation of histone H4 lysine 20 by PR-Set7 ensures the integrity of late replicating sequence domains in Drosophila. 
  • Mimosine targets serine hydroxymethyltransferase. 
  • Mimosine, a novel inhibitor of DNA replication, binds to a 50 kDa protein in Chinese hamster cells. 
  • Minoxidil inhibits ocular cell proliferation and lysyl hydroxylase activity. 
  • Misincorporation and mispaired primer extension by human immunodeficiency virus reverse transcriptase. 
  • Mismatch recognition and subsequent processing have distinct effects on mitotic recombination intermediates and outcomes in yeast. 
  • Mismatch repair in replication fidelity, genetic recombination, and cancer biology. 
  • Mismatch repair, genetic stability, and cancer. 
  • Mitochondrial dynamics and autophagy aid in removal of persistent mitochondrial DNA damage in Caenorhabditis elegans 
  • Modulation of mutagenesis in eukaryotes by DNA replication fork dynamics and quality of nucleotide pools. 
  • Molecular genetics of yeast. 
  • Multiple and specific initiation of T4 DNA replication. 
  • Mutagenesis and the three R's in yeast. 
  • Mutations in TFAM, encoding mitochondrial transcription factor A, cause neonatal liver failure associated with mtDNA depletion. 
  • Nascent chromatin occupancy profiling reveals locus- and factor-specific chromatin maturation dynamics behind the DNA replication fork. 
  • Negative regulation of DNA replication by the retinoblastoma protein is mediated by its association with MCM7. 
  • Neocentromeres: a place for everything and everything in its place. 
  • Network calisthenics: control of E2F dynamics in cell cycle entry. 
  • Nkx2-5 Second Heart Field Target Gene Ccdc117 Regulates DNA Metabolism and Proliferation. 
  • Norfloxacin-induced DNA gyrase cleavage complexes block Escherichia coli replication forks, causing double-stranded breaks in vivo. 
  • Novel PMS1 alleles preferentially affect the repair of primer strand loops during DNA replication. 
  • Nucleosomes influence multiple steps during replication initiation. 
  • ORChestrating the human DNA replication program. 
  • Oligonucleotide transformation of yeast reveals mismatch repair complexes to be differentially active on DNA replication strands. 
  • On ribosomal gene compensation in Drosophila. 
  • Oxygen-induced mitochondrial biogenesis in the rat hippocampus. 
  • PI3K stimulates DNA synthesis and cell-cycle progression via its p55PIK regulatory subunit interaction with PCNA. 
  • PR48, a novel regulatory subunit of protein phosphatase 2A, interacts with Cdc6 and modulates DNA replication in human cells. 
  • Participation of p53 protein in the cellular response to DNA damage. 
  • Patterns of heteroduplex formation associated with the initiation of meiotic recombination in the yeast Saccharomyces cerevisiae. 
  • Persistence of herpes simplex virus type-2 genome in a human leukemic cell line. 
  • Plasmid models for bacteriophage T4 DNA replication: requirements for fork proteins. 
  • Polyamines as intermediates in developmental neurotoxic events. 
  • Polyoma mutants that productively infect F9 embryonal carcinoma cells do not rescue wild-type polyoma in F9 cells. 
  • Polytenization of the ribosomal genes on the X and Y chromosomes of Drosophila melanogaster. 
  • Polyteny: still a giant player in chromosome research. 
  • Preferential DNA-protein cross-linking by NiCl2 in magnesium-insoluble regions of fractionated Chinese hamster ovary cell chromatin. 
  • Preferential re-replication of Drosophila heterochromatin in the absence of geminin. 
  • Preparation and use of interphase Xenopus egg extracts. 
  • Processive DNA synthesis observed in a polymerase crystal suggests a mechanism for the prevention of frameshift mutations. 
  • Protein phosphatase 2A-dependent dephosphorylation of replication protein A is required for the repair of DNA breaks induced by replication stress. 
  • Protein phosphatase 2A: a panoply of enzymes. 
  • Protein-protein and protein-DNA interactions at the bacteriophage T4 DNA replication fork. Characterization of a fluorescently labeled DNA polymerase sliding clamp. 
  • Purification of replication protein C, a cellular protein involved in the initial stages of simian virus 40 DNA replication in vitro. 
  • Purifying selection, sequence composition, and context-specific indel mutations shape intraspecific variation in a bacterial endosymbiont. 
  • Pyroptotic cell death defends against intracellular pathogens. 
  • RCC1, a regulator of mitosis, is essential for DNA replication. 
  • REV1 inhibitor JH-RE-06 enhances tumor cell response to chemotherapy by triggering senescence hallmarks. 
  • RNA subunit of mitochondrial RNA-processing enzyme is induced by contractile activity in striated muscle. 
  • RNA-DNA hybrid formation at a bacteriophage T4 replication origin. 
  • Rapid and specific conversion of precursor interleukin 1 beta (IL-1 beta) to an active IL-1 species by human mast cell chymase. 
  • Recombination hotspots in bacteriophage T4 are dependent on replication origins. 
  • Recombination-dependent DNA replication in phage T4. 
  • Recombination-dependent DNA replication stimulated by double-strand breaks in bacteriophage T4. 
  • Recombination-dependent replication of plasmids during bacteriophage T4 infection. 
  • Reconstitution of simian virus 40 DNA replication with purified proteins. 
  • Reduced expression of transforming growth factor beta type I receptor contributes to the malignancy of human colon carcinoma cells. 
  • Regenerative proliferation in inner ear sensory epithelia from adult guinea pigs and humans. 
  • Regression supports two mechanisms of fork processing in phage T4. 
  • Regulation of CTP Synthase Filament Formation During DNA Endoreplication in Drosophila. 
  • Regulation of mitochondrial biogenesis in skeletal muscle by CaMK. 
  • Regulation of transcription of the repA1 gene in the replication control region of IncFII plasmid NR1 by gene dosage of the repA2 transcription repressor protein. 
  • Repair of double-strand breaks in bacteriophage T4 by a mechanism that involves extensive DNA replication. 
  • Replicating circular DNA molecules in yeast. 
  • Replication and preferential inheritance of hypersuppressive petite mitochondrial DNA. 
  • Replication control of autonomously replicating human sequences. 
  • Replication factors MCM2 and ORC1 interact with the histone acetyltransferase HBO1. 
  • Replication of 13 obesity loci among Singaporean Chinese, Malay and Asian-Indian populations. 
  • Replication of N2-ethyldeoxyguanosine DNA adducts in the human embryonic kidney cell line 293. 
  • Replication of the Escherichia coli chromosome in RNase HI-deficient cells: multiple initiation regions and fork dynamics. 
  • Replication of the vesicular stomatitis virus genome in permissive and nonpermissive host cells. 
  • Replication of yeast chromosomal DNA. 
  • Replication, recombination, and repair: going for the gold. 
  • Requirement of the prolyl isomerase Pin1 for the replication checkpoint. 
  • Resveratrol arrests the cell division cycle at S/G2 phase transition. 
  • Ribonucleotides and Transcription-Associated Mutagenesis in Yeast. 
  • Ribonucleotides in DNA: hidden in plain sight. 
  • Role for E2F in control of both DNA replication and mitotic functions as revealed from DNA microarray analysis. 
  • Role for the PP2A/B56delta phosphatase in regulating 14-3-3 release from Cdc25 to control mitosis. 
  • Role of ATP in DNA synthesis in Escherichia coli. 
  • Role of Escherichia coli DNA polymerase I in conferring viability upon the dnaN159 mutant strain. 
  • Role of MotA transcription factor in bacteriophage T4 DNA replication. 
  • Role of the aryl hydrocarbon receptor in cell cycle regulation. 
  • Roles of RAD6 epistasis group members in spontaneous polzeta-dependent translesion synthesis in Saccharomyces cerevisiae. 
  • Roles of exonucleases and translesion synthesis DNA polymerases during mitotic gap repair in yeast. 
  • SET8 Inhibition Potentiates Radiotherapy by Suppressing DNA Damage Repair in Carcinomas. 
  • SSBP1 mutations cause mtDNA depletion underlying a complex optic atrophy disorder. 
  • SV40 enhancer-binding factors are required at the establishment but not the maintenance step of enhancer-dependent transcriptional activation. 
  • Schedule-dependent enhancement of 1-beta-D-arabinofuranosylcytosine incorporation into HL-60 DNA by deoxyguanosine. 
  • Self-inflicted DNA double-strand breaks sustain tumorigenicity and stemness of cancer cells. 
  • Sensing and Processing of DNA Interstrand Crosslinks by the Mismatch Repair Pathway. 
  • Sequences flanking the pentanucleotide T-antigen binding sites in the polyomavirus core origin help determine selectivity of DNA replication. 
  • Single intraluminal delivery of antisense cdc2 kinase and proliferating-cell nuclear antigen oligonucleotides results in chronic inhibition of neointimal hyperplasia. 
  • Sir2 suppresses transcription-mediated displacement of Mcm2-7 replicative helicases at the ribosomal DNA repeats. 
  • Sites of copy choice replication involved in generation of vesicular stomatitis virus defective-interfering particle RNAs. 
  • Sliding clamp of the bacteriophage T4 polymerase has open and closed subunit interfaces in solution. 
  • Sliding clamp-DNA interactions are required for viability and contribute to DNA polymerase management in Escherichia coli. 
  • SnapShot: Origins of DNA replication. 
  • Stabilization of microsatellite sequences by variant repeats in the yeast Saccharomyces cerevisiae. 
  • Stochastic initiation of DNA replication across the human genome. 
  • Structural insight and characterization of human Twinkle helicase in mitochondrial disease. 
  • Structure of DNA in DNA replication mutants of yeast. 
  • Structure of DNA polymerase I Klenow fragment bound to duplex DNA. 
  • Structure of a high fidelity DNA polymerase bound to a benzo[a]pyrene adduct that blocks replication. 
  • Structure of the human MutSalpha DNA lesion recognition complex. 
  • Structures of mismatch replication errors observed in a DNA polymerase. 
  • Studies on DNA replication in the bacteriophage T4 in vitro system. 
  • Studies on scaffold attachment sites and their relation to genome function. 
  • Studies on the regulation and specificity of the DNA-untwisting enzyme. 
  • Suppression of human corneal epithelial proliferation with breast carcinoma immunotoxin. 
  • T-antigen kinase inhibits simian virus 40 DNA replication by phosphorylation of intact T antigen on serines 120 and 123. 
  • T7-induced DNA polymerase. Requirement for thioredoxin sulfhydryl groups. 
  • Telomerase, cell immortality, and cancer. 
  • Temporal association of ORCA/LRWD1 to late-firing origins during G1 dictates heterochromatin replication and organization. 
  • Temporal profile of replication of human chromosomes. 
  • Tertiary initiation of replication in bacteriophage T4. Deletion of the overlapping uvsY promoter/replication origin from the phage genome. 
  • The 9-1-1 checkpoint clamp physically interacts with polzeta and is partially required for spontaneous polzeta-dependent mutagenesis in Saccharomyces cerevisiae. 
  • The MotA protein from bacteriophage T4 contains two domains. Preliminary structural analysis by X-ray diffraction and nuclear magnetic resonance. 
  • The N2-ethylguanine and the O6-ethyl- and O6-methylguanine lesions in DNA: contrasting responses from the "bypass" DNA polymerase eta and the replicative DNA polymerase alpha. 
  • The combination of novel low molecular weight inhibitors of RAF (LBT613) and target of rapamycin (RAD001) decreases glioma proliferation and invasion. 
  • The conserved bromo-adjacent homology domain of yeast Orc1 functions in the selection of DNA replication origins within chromatin. 
  • The effect of culture density and proliferation rate on the expression of ouabain-sensitive Na/K ATPase pumps in cultured human retinal pigment epithelium. 
  • The effect of oxidative metabolism on spontaneous Pol zeta-dependent translesion synthesis in Saccharomyces cerevisiae. 
  • The effects of aging on phosphofructokinase induction during lymphocyte mitogenesis in relation to DNA and protein synthesis. 
  • The fidelity of DNA replication, particularly on GC-rich templates, is reduced by defects of the Fe-S cluster in DNA polymerase δ. 
  • The histone modification pattern of active genes revealed through genome-wide chromatin analysis of a higher eukaryote. 
  • The human oncoprotein and chromatin architectural factor DEK counteracts DNA replication stress. 
  • The importance of repairing stalled replication forks. 
  • The mechanism of the translocation step in DNA replication by DNA polymerase I: a computer simulation analysis. 
  • The oncoprotein DEK affects the outcome of PARP1/2 inhibition during mild replication stress. 
  • The phage T4 protein UvsW drives Holliday junction branch migration. 
  • The plant amino acid mimosine may inhibit initiation at origins of replication in Chinese hamster cells. 
  • The polymerase eta translesion synthesis DNA polymerase acts independently of the mismatch repair system to limit mutagenesis caused by 7,8-dihydro-8-oxoguanine in yeast. 
  • The role of Dbf4-dependent protein kinase in DNA polymerase ζ-dependent mutagenesis in Saccharomyces cerevisiae. 
  • The role of Exo1p exonuclease in DNA end resection to generate gene conversion tracts in Saccharomyces cerevisiae. 
  • The role of cytoplasmic deoxycytidine kinase in the mitochondrial effects of the anti-human immunodeficiency virus compound, 2',3'-dideoxycytidine. 
  • The role of receptors for complement in the induction of polyclonal B-cell proliferation and differentiation. 
  • The telomere hypothesis of cellular aging. 
  • The thymic microenvironment. Characterization of in vitro differentiation of the IT26R21 rat thymic epithelial cell line. 
  • The tight linkage between DNA replication and double-strand break repair in bacteriophage T4. 
  • Topoisomerase 1-dependent deletions initiated by incision at ribonucleotides are biased to the non-transcribed strand of a highly activated reporter. 
  • Topoisomerase I and Genome Stability: The Good and the Bad. 
  • Transcription as a source of genome instability. 
  • Transcription inhibits the replication of autonomously replicating plasmids in human cells. 
  • Transcription of the terminal loop region of vaccinia virus DNA is initiated from the telomere sequences directing DNA resolution. 
  • Transcription-associated mutagenesis in yeast is directly proportional to the level of gene expression and influenced by the direction of DNA replication. 
  • Transcription-associated mutagenesis. 
  • Transcriptional pausing in a region important for plasmid NR1 replication control. 
  • Transcriptional repressor functions of Drosophila E2F1 and E2F2 cooperate to inhibit genomic DNA synthesis in ovarian follicle cells. 
  • Transposon Tn5: specific sequence recognition and conservative transposition. 
  • Treatment of murine peritoneal macrophages with bacterial lipopolysaccharide alters expression of c-fos and c-myc oncogenes. 
  • Two molecularly distinct G(2)/M checkpoints are induced by ionizing irradiation. 
  • Two-dimensional gel analysis of rolling circle replication in the presence and absence of bacteriophage T4 primase. 
  • Type I elements mediate replication fork pausing at conserved upstream sites in the Tetrahymena thermophila ribosomal DNA minichromosome. 
  • Ubiquitylation of p53 by the APC/C inhibitor Trim39. 
  • Unusual chromosome architecture and behaviour at an HSR. 
  • UvsW protein regulates bacteriophage T4 origin-dependent replication by unwinding R-loops. 
  • Vascular smooth muscle cell hypertrophy vs. hyperplasia. Autocrine transforming growth factor-beta 1 expression determines growth response to angiotensin II. 
  • Visualization of replication initiation and elongation in Drosophila. 
  • Visualizing DNA replication in a catalytically active Bacillus DNA polymerase crystal. 
  • Wild-type p53 is a cell cycle checkpoint determinant following irradiation. 
  • Yeast RPO41 gene product is required for transcription and maintenance of the mitochondrial genome. 
  • Yeast chromosomal DNA: size, structure, and replication. 
  • [125I]iodo-epidermal growth factor binding and mitotic responsiveness of porcine granulosa cells are modulated by differentiation and follicle-stimulating hormone. 
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  Keywords of People

  • Cianciolo, George James, Associate Professor Emeritus of Pathology, Pathology
  • Erickson, Harold Paul, James B. Duke Distinguished Professor Emeritus, Cell Biology
  • McLendon, Roger Edwin, Professor of Pathology, Pathology
  • Meyer, Joel, Associate Professor of Environmental Genomics in the Division of Environmental Sciences and Policy, Nicholas Institute-Energy Initiative
  • Sullivan, Beth Ann, Professor of Molecular Genetics and Microbiology, Duke Science & Society