DNA Helicases

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  Subject Areas on Research

  • A high-throughput CRISPR interference screen for dissecting functional regulators of GPCR/cAMP signaling. 
  • A novel relaxase homologue is involved in chromosomal DNA processing for type IV secretion in Neisseria gonorrhoeae. 
  • Altered telomeres in tumors with ATRX and DAXX mutations. 
  • Analysis of 60 reported glioma risk SNPs replicates published GWAS findings but fails to replicate associations from published candidate-gene studies. 
  • Analysis of the individual regulatory components of the IncFII plasmid replication control system. 
  • Association between fulminant hepatic failure and a strain of GBV virus C. 
  • Association of sequence variants on chromosomes 20, 11, and 5 (20q13.33, 11q23.3, and 5p15.33) with glioma susceptibility in a Chinese population. 
  • Associations between expression levels of nucleotide excision repair proteins in lymphoblastoid cells and risk of squamous cell carcinoma of the head and neck. 
  • BLM-DNA2-RPA-MRN and EXO1-BLM-RPA-MRN constitute two DNA end resection machineries for human DNA break repair. 
  • BRG1 and BRM SWI/SNF ATPases redundantly maintain cardiomyocyte homeostasis by regulating cardiomyocyte mitophagy and mitochondrial dynamics in vivo. 
  • Bacteriophage T4 UvsW protein is a helicase involved in recombination, repair and the regulation of DNA replication origins. 
  • Bacteriophage T4 gene 41 helicase and gene 59 helicase-loading protein: a versatile couple with roles in replication and recombination. 
  • Bacteriophage T4 initiates bidirectional DNA replication through a two-step process. 
  • Bacteriophage T4 proteins replicate plasmids with a preformed R loop at the T4 ori(uvsY) replication origin in vitro. 
  • CHD8 regulates neurodevelopmental pathways associated with autism spectrum disorder in neural progenitors. 
  • Complete DiGeorge syndrome associated with CHD7 mutation. 
  • Conserved motifs II to VI of DNA helicase II from Escherichia coli are all required for biological activity. 
  • Crystal structure of the phage T4 recombinase UvsX and its functional interaction with the T4 SF2 helicase UvsW. 
  • Cutaneous metastasis of SMARCA4-deficient thoracic sarcoma: A diagnostic dilemma with therapeutic implications. 
  • DAXX/ATRX, MEN1, and mTOR pathway genes are frequently altered in pancreatic neuroendocrine tumors. 
  • DNA breakage and closure by rat liver type 1 topoisomerase: separation of the half-reactions by using a single-stranded DNA substrate. 
  • DNA repair gene ERCC1 and ERCC2/XPD polymorphisms and risk of squamous cell carcinoma of the head and neck. 
  • DNA repair gene XPD polymorphism and lung cancer risk: a meta-analysis. 
  • Defective dendritic cell maturation in a child with nucleotide excision repair deficiency and CD4 lymphopenia. 
  • Dependence of the regulation of telomere length on the type of subtelomeric repeat in the yeast Saccharomyces cerevisiae. 
  • Disruption of a topoisomerase-DNA cleavage complex by a DNA helicase. 
  • ERCC6/CSB gene polymorphisms and lung cancer risk. 
  • Enhancer-origin interaction in plasmid R6K involves a DNA loop mediated by initiator protein. 
  • Epithelial-mesenchymal transitions and hepatocarcinogenesis. 
  • Examination of the roles of Sgs1 and Srs2 helicases in the enforcement of recombination fidelity in Saccharomyces cerevisiae. 
  • Exome-wide Sequencing Shows Low Mutation Rates and Identifies Novel Mutated Genes in Seminomas. 
  • Expression and function of the uvsW gene of bacteriophage T4. 
  • Expression of nucleotide excision repair genes and the risk for squamous cell carcinoma of the head and neck. 
  • Flow linear dichroism and electron microscopic analysis of protein-DNA complexes of a mutant UvrB protein that binds to but cannot kink DNA. 
  • Fork regression is an active helicase-driven pathway in bacteriophage T4. 
  • Frequent ATRX, CIC, FUBP1 and IDH1 mutations refine the classification of malignant gliomas. 
  • Functional genetic variants of RUVBL1 predict overall survival of Chinese patients with epithelial ovarian cancer. 
  • G3BP1, G3BP2 and CAPRIN1 are required for translation of interferon stimulated mRNAs and are targeted by a dengue virus non-coding RNA. 
  • Genetic variants in telomerase-related genes are associated with an older age at diagnosis in glioma patients: evidence for distinct pathways of gliomagenesis. 
  • Genetic variants of the nonhomologous end joining gene LIG4 and severe radiation pneumonitis in nonsmall cell lung cancer patients treated with definitive radiotherapy. 
  • Genome-wide association and functional follow-up reveals new loci for kidney function. 
  • Genomic distribution of CHD7 on chromatin tracks H3K4 methylation patterns. 
  • Germline and somatic SMARCA4 mutations characterize small cell carcinoma of the ovary, hypercalcemic type. 
  • Gibberellin Signaling Requires Chromatin Remodeler PICKLE to Promote Vegetative Growth and Phase Transitions. 
  • Guanine repeat-containing sequences confer transcription-dependent instability in an orientation-specific manner in yeast. 
  • HLA polymorphisms in African Americans with idiopathic inflammatory myopathy: allelic profiles distinguish patients with different clinical phenotypes and myositis autoantibodies. 
  • Heteroduplex DNA position defines the roles of the Sgs1, Srs2, and Mph1 helicases in promoting distinct recombination outcomes. 
  • High circulatory leptin mediated NOX-2-peroxynitrite-miR21 axis activate mesangial cells and promotes renal inflammatory pathology in nonalcoholic fatty liver disease. 
  • High-Resolution Mapping of Homologous Recombination Events in rad3 Hyper-Recombination Mutants in Yeast. 
  • Human exonuclease 1 and BLM helicase interact to resect DNA and initiate DNA repair. 
  • Identification and characterization of Escherichia coli DNA helicase II mutants that exhibit increased unwinding efficiency. 
  • In vitro studies on the bacteriophage P2 terminase system. 
  • In-vivo studies on the cis-acting replication initiator protein of IncFII plasmid NR1. 
  • Inhibition of DNA helicase II unwinding and ATPase activities by DNA-interacting ligands. Kinetics and specificity. 
  • Isolation and characterization of the replicon of a Thiobacillus intermedius plasmid. 
  • Lung Transplant Outcomes in Patients With Pulmonary Fibrosis With Telomere-Related Gene Variants. 
  • Mechanism of activation of simian virus 40 DNA replication by protein phosphatase 2A. 
  • Mechanism of staphylococcal multiresistance plasmid replication origin assembly by the RepA protein. 
  • Mechanisms in E. coli and Human Mismatch Repair (Nobel Lecture). 
  • Mechanisms of DNA-mismatch correction. 
  • Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways. 
  • Mismatch-, MutS-, MutL-, and helicase II-dependent unwinding from the single-strand break of an incised heteroduplex. 
  • Missense and truncating variants in CHD5 in a dominant neurodevelopmental disorder with intellectual disability, behavioral disturbances, and epilepsy. 
  • Modulation of nucleotide excision repair capacity by XPD polymorphisms in lung cancer patients. 
  • Molecular Profiling Reveals Biologically Discrete Subsets and Pathways of Progression in Diffuse Glioma. 
  • Murine monoclonal antibodies specific for conserved and non-conserved antigenic determinants of the human and murine Ku autoantigens. 
  • MutS and MutL activate DNA helicase II in a mismatch-dependent manner. 
  • Mutations in CIC and FUBP1 contribute to human oligodendroglioma. 
  • Novel mutations target distinct subgroups of medulloblastoma. 
  • Nucleosomes influence multiple steps during replication initiation. 
  • Polymorphisms in the two helicases ERCC2/XPD and ERCC3/XPB of the transcription factor IIH complex and risk of lung cancer: a case-control analysis in a Chinese population. 
  • Polymorphisms of the DNA repair gene XPD and risk of lung cancer in a Chinese population. 
  • Proliferation of Double-Strand Break-Resistant Polyploid Cells Requires Drosophila FANCD2. 
  • Protein roadblocks and helix discontinuities are barriers to the initiation of mismatch repair. 
  • Purification of replication protein C, a cellular protein involved in the initial stages of simian virus 40 DNA replication in vitro. 
  • Rare Protein-Altering Telomere-related Gene Variants in Patients with Chronic Hypersensitivity Pneumonitis. 
  • Reduced DNA repair of benzo[a]pyrene diol epoxide-induced adducts and common XPD polymorphisms in breast cancer patients. 
  • Reduced expression levels of nucleotide excision repair genes in lung cancer: a case-control analysis. 
  • Reduced mRNA expression of nucleotide excision repair genes in lymphocytes and risk of squamous cell carcinoma of the head and neck. 
  • Regulation of transcription of the repA1 gene in the replication control region of IncFII plasmid NR1 by gene dosage of the repA2 transcription repressor protein. 
  • Relationship between expression of coactivators and corepressors of hormone receptors and resistance of ovarian cancers to growth regulation by steroid hormones. 
  • Role of the Srs2-Rad51 Interaction Domain in Crossover Control in Saccharomyces cerevisiae. 
  • Roles of RAD6 epistasis group members in spontaneous polzeta-dependent translesion synthesis in Saccharomyces cerevisiae. 
  • SMARCA4 and Other SWItch/Sucrose NonFermentable Family Genomic Alterations in NSCLC: Clinicopathologic Characteristics and Outcomes to Immune Checkpoint Inhibition. 
  • Saccharomyces cerevisiae RAD5-encoded DNA repair protein contains DNA helicase and zinc-binding sequence motifs and affects the stability of simple repetitive sequences in the genome. 
  • Sec63 and Xbp1 regulate IRE1α activity and polycystic disease severity. 
  • Senataxin mutations elicit motor neuron degeneration phenotypes and yield TDP-43 mislocalization in ALS4 mice and human patients. 
  • Senataxin, A Novel Helicase at the Interface of RNA Transcriptome Regulation and Neurobiology: From Normal Function to Pathological Roles in Motor Neuron Disease and Cerebellar Degeneration. 
  • Shared genetic pathways contribute to the tolerance of endogenous and low-dose exogenous DNA damage in yeast. 
  • Significant effect of homologous recombination DNA repair gene polymorphisms on pancreatic cancer survival. 
  • Single nucleotide polymorphisms of RecQ1, RAD54L, and ATM genes are associated with reduced survival of pancreatic cancer. 
  • Structure and function of the UvrB protein. 
  • T-antigen kinase inhibits simian virus 40 DNA replication by phosphorylation of intact T antigen on serines 120 and 123. 
  • Tagging SNPs in non-homologous end-joining pathway genes and risk of glioma. 
  • The DNA helicase activities of Rad3 protein of Saccharomyces cerevisiae and helicase II of Escherichia coli are differentially inhibited by covalent and noncovalent DNA modifications. 
  • The DNA-binding protein Hdf1p (a putative Ku homologue) is required for maintaining normal telomere length in Saccharomyces cerevisiae. 
  • The Genetic Basis of Hepatosplenic T-cell Lymphoma. 
  • The T4 phage SF1B helicase Dda is structurally optimized to perform DNA strand separation. 
  • The crystal structure of the UvsW helicase from bacteriophage T4. 
  • The genetic landscape of mutations in Burkitt lymphoma. 
  • The genome's best friend. 
  • The genomic landscape of TERT promoter wildtype-IDH wildtype glioblastoma. 
  • The genomic landscape of mantle cell lymphoma is related to the epigenetically determined chromatin state of normal B cells. 
  • The hereditary nature of small cell carcinoma of the ovary, hypercalcemic type: two new familial cases. 
  • The influence of clinical and genetic factors on patient outcome in small cell carcinoma of the ovary, hypercalcemic type. 
  • The mismatch DNA repair heterodimer, hMSH2/6, regulates BLM helicase. 
  • The phage T4 protein UvsW drives Holliday junction branch migration. 
  • UvsW protein regulates bacteriophage T4 origin-dependent replication by unwinding R-loops. 
  • XPD/ERCC2 EXON 8 Polymorphisms: rarity and lack of significance in risk of squamous cell carcinoma of the head and neck. 
  • XPD/ERCC2 polymorphisms and risk of head and neck cancer: a case-control analysis. 
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  Keywords of People

  • Berchuck, Andrew, James M. Ingram Distinguished Professor of Gynecologic Oncology, Obstetrics and Gynecology, Gynecologic Oncology
  • Erickson, Harold Paul, James B. Duke Distinguished Professor of Cell Biology, Cell Biology
  • McLendon, Roger Edwin, Professor of Pathology, Pathology
  • Yan, Hai, Henry S. Friedman Distinguished Professor of Neuro-Oncology in the School of Medicine, Pathology