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Subject Areas on Research
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A high-throughput CRISPR interference screen for dissecting functional regulators of GPCR/cAMP signaling.
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A novel relaxase homologue is involved in chromosomal DNA processing for type IV secretion in Neisseria gonorrhoeae.
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Altered telomeres in tumors with ATRX and DAXX mutations.
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Analysis of 60 reported glioma risk SNPs replicates published GWAS findings but fails to replicate associations from published candidate-gene studies.
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Analysis of the individual regulatory components of the IncFII plasmid replication control system.
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Association of sequence variants on chromosomes 20, 11, and 5 (20q13.33, 11q23.3, and 5p15.33) with glioma susceptibility in a Chinese population.
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Associations between expression levels of nucleotide excision repair proteins in lymphoblastoid cells and risk of squamous cell carcinoma of the head and neck.
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BLM-DNA2-RPA-MRN and EXO1-BLM-RPA-MRN constitute two DNA end resection machineries for human DNA break repair.
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BRG1 and BRM SWI/SNF ATPases redundantly maintain cardiomyocyte homeostasis by regulating cardiomyocyte mitophagy and mitochondrial dynamics in vivo.
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BRG1 is a biomarker of hypertrophic cardiomyopathy in human heart specimens.
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Bacteriophage T4 UvsW protein is a helicase involved in recombination, repair and the regulation of DNA replication origins.
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Bacteriophage T4 gene 41 helicase and gene 59 helicase-loading protein: a versatile couple with roles in replication and recombination.
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Bacteriophage T4 initiates bidirectional DNA replication through a two-step process.
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Bacteriophage T4 proteins replicate plasmids with a preformed R loop at the T4 ori(uvsY) replication origin in vitro.
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Clinical relevance of molecular characteristics in Burkitt lymphoma differs according to age.
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Complete DiGeorge syndrome associated with CHD7 mutation.
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Conserved Structural Motif Identified in Peptides That Bind to Geminivirus Replication Protein Rep.
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Conserved motifs II to VI of DNA helicase II from Escherichia coli are all required for biological activity.
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Crystal structure of the phage T4 recombinase UvsX and its functional interaction with the T4 SF2 helicase UvsW.
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Cutaneous metastasis of SMARCA4-deficient thoracic sarcoma: A diagnostic dilemma with therapeutic implications.
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DAXX/ATRX, MEN1, and mTOR pathway genes are frequently altered in pancreatic neuroendocrine tumors.
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DNA breakage and closure by rat liver type 1 topoisomerase: separation of the half-reactions by using a single-stranded DNA substrate.
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DNA repair gene ERCC1 and ERCC2/XPD polymorphisms and risk of squamous cell carcinoma of the head and neck.
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DNA repair gene XPD polymorphism and lung cancer risk: a meta-analysis.
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Defective dendritic cell maturation in a child with nucleotide excision repair deficiency and CD4 lymphopenia.
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Dependence of the regulation of telomere length on the type of subtelomeric repeat in the yeast Saccharomyces cerevisiae.
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Disruption of a topoisomerase-DNA cleavage complex by a DNA helicase.
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ERCC6/CSB gene polymorphisms and lung cancer risk.
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Enhancer-origin interaction in plasmid R6K involves a DNA loop mediated by initiator protein.
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Epithelial-mesenchymal transitions and hepatocarcinogenesis.
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Examination of the roles of Sgs1 and Srs2 helicases in the enforcement of recombination fidelity in Saccharomyces cerevisiae.
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Exome-wide Sequencing Shows Low Mutation Rates and Identifies Novel Mutated Genes in Seminomas.
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Expression and function of the uvsW gene of bacteriophage T4.
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Expression of nucleotide excision repair genes and the risk for squamous cell carcinoma of the head and neck.
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Flow linear dichroism and electron microscopic analysis of protein-DNA complexes of a mutant UvrB protein that binds to but cannot kink DNA.
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Fork regression is an active helicase-driven pathway in bacteriophage T4.
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Frequent ATRX, CIC, FUBP1 and IDH1 mutations refine the classification of malignant gliomas.
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Functional genetic variants of RUVBL1 predict overall survival of Chinese patients with epithelial ovarian cancer.
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Genetic predisposition to longer telomere length and risk of childhood, adolescent and adult-onset ependymoma.
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Genetic variants in telomerase-related genes are associated with an older age at diagnosis in glioma patients: evidence for distinct pathways of gliomagenesis.
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Genetic variants of the nonhomologous end joining gene LIG4 and severe radiation pneumonitis in nonsmall cell lung cancer patients treated with definitive radiotherapy.
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Genome-wide association and functional follow-up reveals new loci for kidney function.
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Genomic distribution of CHD7 on chromatin tracks H3K4 methylation patterns.
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Germline and somatic SMARCA4 mutations characterize small cell carcinoma of the ovary, hypercalcemic type.
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Gibberellin Signaling Requires Chromatin Remodeler PICKLE to Promote Vegetative Growth and Phase Transitions.
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Guanine repeat-containing sequences confer transcription-dependent instability in an orientation-specific manner in yeast.
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HLA polymorphisms in African Americans with idiopathic inflammatory myopathy: allelic profiles distinguish patients with different clinical phenotypes and myositis autoantibodies.
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Heteroduplex DNA position defines the roles of the Sgs1, Srs2, and Mph1 helicases in promoting distinct recombination outcomes.
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High circulatory leptin mediated NOX-2-peroxynitrite-miR21 axis activate mesangial cells and promotes renal inflammatory pathology in nonalcoholic fatty liver disease.
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High-Resolution Mapping of Homologous Recombination Events in rad3 Hyper-Recombination Mutants in Yeast.
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Human exonuclease 1 and BLM helicase interact to resect DNA and initiate DNA repair.
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Identification and characterization of Escherichia coli DNA helicase II mutants that exhibit increased unwinding efficiency.
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In vitro studies on the bacteriophage P2 terminase system.
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In-vivo studies on the cis-acting replication initiator protein of IncFII plasmid NR1.
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Inhibition of DNA helicase II unwinding and ATPase activities by DNA-interacting ligands. Kinetics and specificity.
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Interplay between structure-specific endonucleases for crossover control during Caenorhabditis elegans meiosis.
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Isolation and characterization of the replicon of a Thiobacillus intermedius plasmid.
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Lung Transplant Outcomes in Patients With Pulmonary Fibrosis With Telomere-Related Gene Variants.
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Mechanism of activation of simian virus 40 DNA replication by protein phosphatase 2A.
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Mechanism of staphylococcal multiresistance plasmid replication origin assembly by the RepA protein.
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Mechanisms in E. coli and Human Mismatch Repair (Nobel Lecture).
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Mechanisms of DNA-mismatch correction.
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Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways.
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Method for the structural analysis of Twinkle mitochondrial DNA helicase by cryo-EM.
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Mismatch-, MutS-, MutL-, and helicase II-dependent unwinding from the single-strand break of an incised heteroduplex.
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Missense and truncating variants in CHD5 in a dominant neurodevelopmental disorder with intellectual disability, behavioral disturbances, and epilepsy.
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Modulation of nucleotide excision repair capacity by XPD polymorphisms in lung cancer patients.
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Molecular Profiling Reveals Biologically Discrete Subsets and Pathways of Progression in Diffuse Glioma.
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Murine monoclonal antibodies specific for conserved and non-conserved antigenic determinants of the human and murine Ku autoantigens.
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MutS and MutL activate DNA helicase II in a mismatch-dependent manner.
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Mutations in CIC and FUBP1 contribute to human oligodendroglioma.
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Nucleosomes influence multiple steps during replication initiation.
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Polymorphisms in the two helicases ERCC2/XPD and ERCC3/XPB of the transcription factor IIH complex and risk of lung cancer: a case-control analysis in a Chinese population.
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Polymorphisms of the DNA repair gene XPD and risk of lung cancer in a Chinese population.
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Proliferation of Double-Strand Break-Resistant Polyploid Cells Requires Drosophila FANCD2.
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Protein roadblocks and helix discontinuities are barriers to the initiation of mismatch repair.
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Purification of replication protein C, a cellular protein involved in the initial stages of simian virus 40 DNA replication in vitro.
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Rare Protein-Altering Telomere-related Gene Variants in Patients with Chronic Hypersensitivity Pneumonitis.
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Reduced DNA repair of benzo[a]pyrene diol epoxide-induced adducts and common XPD polymorphisms in breast cancer patients.
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Reduced expression levels of nucleotide excision repair genes in lung cancer: a case-control analysis.
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Reduced mRNA expression of nucleotide excision repair genes in lymphocytes and risk of squamous cell carcinoma of the head and neck.
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Regulation of transcription of the repA1 gene in the replication control region of IncFII plasmid NR1 by gene dosage of the repA2 transcription repressor protein.
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Relationship between expression of coactivators and corepressors of hormone receptors and resistance of ovarian cancers to growth regulation by steroid hormones.
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Resequencing Study Confirms That Host Defense and Cell Senescence Gene Variants Contribute to the Risk of Idiopathic Pulmonary Fibrosis.
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Role of the Srs2-Rad51 Interaction Domain in Crossover Control in Saccharomyces cerevisiae.
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Roles of RAD6 epistasis group members in spontaneous polzeta-dependent translesion synthesis in Saccharomyces cerevisiae.
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SMARCA4 and Other SWItch/Sucrose NonFermentable Family Genomic Alterations in NSCLC: Clinicopathologic Characteristics and Outcomes to Immune Checkpoint Inhibition.
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Saccharomyces cerevisiae RAD5-encoded DNA repair protein contains DNA helicase and zinc-binding sequence motifs and affects the stability of simple repetitive sequences in the genome.
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Sec63 and Xbp1 regulate IRE1α activity and polycystic disease severity.
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Senataxin mutations elicit motor neuron degeneration phenotypes and yield TDP-43 mislocalization in ALS4 mice and human patients.
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Senataxin, A Novel Helicase at the Interface of RNA Transcriptome Regulation and Neurobiology: From Normal Function to Pathological Roles in Motor Neuron Disease and Cerebellar Degeneration.
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Shared genetic pathways contribute to the tolerance of endogenous and low-dose exogenous DNA damage in yeast.
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Significant effect of homologous recombination DNA repair gene polymorphisms on pancreatic cancer survival.
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Single nucleotide polymorphisms of RecQ1, RAD54L, and ATM genes are associated with reduced survival of pancreatic cancer.
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Structural insight and characterization of human Twinkle helicase in mitochondrial disease.
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Structure and function of the UvrB protein.
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T-antigen kinase inhibits simian virus 40 DNA replication by phosphorylation of intact T antigen on serines 120 and 123.
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Tagging SNPs in non-homologous end-joining pathway genes and risk of glioma.
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The DEXH protein product of the DHX36 gene is the major source of tetramolecular quadruplex G4-DNA resolving activity in HeLa cell lysates.
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The DNA helicase activities of Rad3 protein of Saccharomyces cerevisiae and helicase II of Escherichia coli are differentially inhibited by covalent and noncovalent DNA modifications.
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The DNA-binding protein Hdf1p (a putative Ku homologue) is required for maintaining normal telomere length in Saccharomyces cerevisiae.
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The Genetic Basis of Hepatosplenic T-cell Lymphoma.
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The T4 phage SF1B helicase Dda is structurally optimized to perform DNA strand separation.
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The crystal structure of the UvsW helicase from bacteriophage T4.
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The genetic landscape of mutations in Burkitt lymphoma.
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The genome's best friend.
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The genomic landscape of TERT promoter wildtype-IDH wildtype glioblastoma.
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The genomic landscape of mantle cell lymphoma is related to the epigenetically determined chromatin state of normal B cells.
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The hereditary nature of small cell carcinoma of the ovary, hypercalcemic type: two new familial cases.
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The influence of clinical and genetic factors on patient outcome in small cell carcinoma of the ovary, hypercalcemic type.
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The mismatch DNA repair heterodimer, hMSH2/6, regulates BLM helicase.
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The phage T4 protein UvsW drives Holliday junction branch migration.
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UvsW protein regulates bacteriophage T4 origin-dependent replication by unwinding R-loops.
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XPD/ERCC2 EXON 8 Polymorphisms: rarity and lack of significance in risk of squamous cell carcinoma of the head and neck.
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XPD/ERCC2 polymorphisms and risk of head and neck cancer: a case-control analysis.
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Keywords of People
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Berchuck, Andrew,
James M. Ingram Distinguished Professor of Gynecologic Oncology,
Obstetrics and Gynecology, Gynecologic Oncology
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Erickson, Harold Paul,
Professor Emeritus of Cell Biology,
Cell Biology
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McLendon, Roger Edwin,
Professor of Pathology,
Pathology
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Yan, Hai,
Adjunct Professor of Pathology,
Pathology