DNA-Binding Proteins

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  Subject Areas on Research

  • 'Interactive' recognition in EcoRI restriction enzyme-DNA complex. 
  • 14-3-3 proteins are part of an abscisic acid-VIVIPAROUS1 (VP1) response complex in the Em promoter and interact with VP1 and EmBP1. 
  • 3-Aminopyrrolidinone farnesyltransferase inhibitors: design of macrocyclic compounds with improved pharmacokinetics and excellent cell potency. 
  • 3-nitrotyrosine attenuates respiratory syncytial virus infection in human bronchial epithelial cell line. 
  • 450K epigenome-wide scan identifies differential DNA methylation in newborns related to maternal smoking during pregnancy. 
  • 4D MRI of polycystic kidneys from rapamycin-treated Glis3-deficient mice. 
  • 5-Hydroxymethylcytosine (5hmC) and Ten-eleven translocation 1-3 (TET1-3) proteins in the dorsal root ganglia of mouse: Expression and dynamic regulation in neuropathic pain. 
  • A 30-kDa alternative translation product of the CCAAT/enhancer binding protein alpha message: transcriptional activator lacking antimitotic activity. 
  • A 40-kilodalton protein binds specifically to an upstream sequence element essential for muscle-specific transcription of the human myoglobin promoter. 
  • A Cross-Cancer Genetic Association Analysis of the DNA Repair and DNA Damage Signaling Pathways for Lung, Ovary, Prostate, Breast, and Colorectal Cancer. 
  • A Drosophila CREB/CREM homolog encodes multiple isoforms, including a cyclic AMP-dependent protein kinase-responsive transcriptional activator and antagonist. 
  • A Functionally Conserved Gene Regulatory Network Module Governing Olfactory Neuron Diversity. 
  • A Molecular Switch Regulating Cell Fate Choice between Muscle Progenitor Cells and Brown Adipocytes. 
  • A PRDM16-Driven Metabolic Signal from Adipocytes Regulates Precursor Cell Fate. 
  • A Pseudomonas syringae type III effector suppresses cell wall-based extracellular defense in susceptible Arabidopsis plants. 
  • A Xenopus egg factor with DNA-binding properties characteristic of terminus-specific telomeric proteins. 
  • A binding site for Pax proteins regulates expression of the gene for the neural cell adhesion molecule in the embryonic spinal cord. 
  • A c-Fos- and E1A-interacting component of the tissue factor basal promoter complex mediates synergistic activation of transcription by transforming growth factor-beta1. 
  • A cAMP response element in the beta 2-adrenergic receptor gene confers transcriptional autoregulation by cAMP. 
  • A calcineurin-dependent transcriptional pathway controls skeletal muscle fiber type. 
  • A calcium-responsive transcription factor, CaRF, that regulates neuronal activity-dependent expression of BDNF. 
  • A cell-specific nuclear receptor is essential for adrenal and gonadal development and sexual differentiation. 
  • A cell-specific nuclear receptor plays essential roles in adrenal and gonadal development. 
  • A cell-specific nuclear receptor regulates the steroid hydroxylases. 
  • A combined syndrome of juvenile polyposis and hereditary haemorrhagic telangiectasia associated with mutations in MADH4 (SMAD4). 
  • A connection between stress and development in the multicellular prokaryote Streptomyces coelicolor A3(2). 
  • A conserved docking motif for CK1 binding controls the nuclear localization of NFAT1. 
  • A conserved domain of the viviparous-1 gene product enhances the DNA binding activity of the bZIP protein EmBP-1 and other transcription factors. 
  • A conserved transcriptional enhancer regulates RAG gene expression in developing B cells. 
  • A cut above the other caspases. 
  • A defined human system that supports bidirectional mismatch-provoked excision. 
  • A dimerized coiled-coil domain and an adjoining part of geminin interact with two sites on Cdt1 for replication inhibition. 
  • A direct link between carbohydrate utilization and virulence in the major human pathogen group A Streptococcus. 
  • A flexible statistical model for alignment of label-free proteomics data--incorporating ion mobility and product ion information. 
  • A framework for integrating the songbird brain. 
  • A gene mapping to the sex-determining region of the mouse Y chromosome is a member of a novel family of embryonically expressed genes. 
  • A gene therapy strategy using a transcription factor decoy of the E2F binding site inhibits smooth muscle proliferation in vivo. 
  • A genetic investigation of E2A function in lymphocyte development. 
  • A genetically tractable model of human glioma formation. 
  • A genome-wide association study identifies susceptibility loci for ovarian cancer at 2q31 and 8q24. 
  • A genomic approach to identify regulatory nodes in the transcriptional network of systemic acquired resistance in plants. 
  • A hot spot for hydrogen peroxide-induced damage in the human hypoxia-inducible factor 1 binding site of the PGK 1 gene. 
  • A human erythropoietin receptor gene mutant causing familial erythrocytosis is associated with deregulation of the rates of Jak2 and Stat5 inactivation. 
  • A human gamma globin gene variant binds SP1. 
  • A hypermutation phenotype and somatic MSH6 mutations in recurrent human malignant gliomas after alkylator chemotherapy. 
  • A mechanism of COOH-terminal binding protein-mediated repression. 
  • A mouse homologue of FAST-1 transduces TGF beta superfamily signals and is expressed during early embryogenesis. 
  • A naturally occurring gamma globin gene mutation enhances SP1 binding activity. 
  • A naturally occurring hPMS2 mutation can confer a dominant negative mutator phenotype. 
  • A network of genetic events sufficient to convert normal human cells to a tumorigenic state. 
  • A new H/D exchange- and mass spectrometry-based method for thermodynamic analysis of protein-DNA interactions. 
  • A new activating role for CO in cardiac mitochondrial biogenesis. 
  • A new role for ATM: regulating mitochondrial function and mitophagy. 
  • A new trick for Cyclin-Cdk: activation of STAT. 
  • A noncanonical function of cGAMP in inflammasome priming and activation. 
  • A novel ATM-dependent pathway regulates protein phosphatase 1 in response to DNA damage. 
  • A novel Cbx1, PurB, and Sp3 complex mediates long-term silencing of tissue- and lineage-specific genes. 
  • A novel T-77C polymorphism in DNA repair gene XRCC1 contributes to diminished promoter activity and increased risk of non-small cell lung cancer. 
  • A novel XPF -357A>C polymorphism predicts risk and recurrence of bladder cancer. 
  • A novel human cancer culture model for the study of prostate cancer. 
  • A novel role for HEB downstream or parallel to the pre-TCR signaling pathway during alpha beta thymopoiesis. 
  • A pathogenetic role for TNF alpha in the syndrome of cachexia, arthritis, and autoimmunity resulting from tristetraprolin (TTP) deficiency. 
  • A potential role for Elf-1 in CD4 promoter function. 
  • A promoter polymorphism (-77T>C) of DNA repair gene XRCC1 is associated with risk of lung cancer in relation to tobacco smoking. 
  • A prospective prostate cancer screening programme for men with pathogenic variants in mismatch repair genes (IMPACT): initial results from an international prospective study. 
  • A protein encoded within the Down syndrome critical region is enriched in striated muscles and inhibits calcineurin signaling. 
  • A quantitative, high-throughput screen for protein stability. 
  • A rapid micropreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells. 
  • A recessive variant of XRCC4 predisposes to non- BRCA1/2 breast cancer in chinese women and impairs the DNA damage response via dysregulated nuclear localization. 
  • A regulatory hierarchy controls the dynamic transcriptional response to extreme oxidative stress in archaea. 
  • A role for Pin1 in mammalian germ cell development and spermatogenesis. 
  • A role for cohesin in T-cell-receptor rearrangement and thymocyte differentiation. 
  • A role for histone acetylation in the developmental regulation of VDJ recombination. 
  • A role for nuclear inositol 1,4,5-trisphosphate kinase in transcriptional control. 
  • A role for sonic hedgehog signaling in the pathogenesis of human tracheoesophageal fistula. 
  • A role for the orphan steroid receptor Nur77 in apoptosis accompanying antigen-induced negative selection. 
  • A sensitized mutagenesis screen identifies Gli3 as a modifier of Sox10 neurocristopathy. 
  • A soluble factor(s) secreted from CD8(+) T lymphocytes inhibits human immunodeficiency virus type 1 replication through STAT1 activation. 
  • A stimulus-specific role for CREB-binding protein (CBP) in T cell receptor-activated tumor necrosis factor alpha gene expression. 
  • A subtle t(3;8) results in plausible juxtaposition of MYC and BCL6 in a child with Burkitt lymphoma/leukemia and ataxia-telangiectasia. 
  • A telomerase-immortalized primary human prostate cancer clonal cell line with neoplastic phenotypes. 
  • A transcription factor links growth rate and metabolism in the hypersaline adapted archaeon Halobacterium salinarum. 
  • A transcription network of interlocking positive feedback loops maintains intracellular iron balance in archaea. 
  • A user's guide to the encyclopedia of DNA elements (ENCODE). 
  • A variant at a potentially functional microRNA-binding site in BRIP1 was associated with risk of squamous cell carcinoma of the head and neck. 
  • A variant of the DNA repair gene XRCC3 and risk of squamous cell carcinoma of the head and neck: a case-control analysis. 
  • A whole-genome association study of major determinants for host control of HIV-1. 
  • A20 modulates lipid metabolism and energy production to promote liver regeneration. 
  • A20 protects endothelial cells from TNF-, Fas-, and NK-mediated cell death by inhibiting caspase 8 activation. 
  • A20 protects from CD40-CD40 ligand-mediated endothelial cell activation and apoptosis. 
  • A20 protects mice from D-galactosamine/lipopolysaccharide acute toxic lethal hepatitis. 
  • A20, a modulator of smooth muscle cell proliferation and apoptosis, prevents and induces regression of neointimal hyperplasia. 
  • ACTL6A Is Co-Amplified with p63 in Squamous Cell Carcinoma to Drive YAP Activation, Regenerative Proliferation, and Poor Prognosis. 
  • AIF-1 in the activated smooth muscle cell : spectator or participant? 
  • ARID1A Is Essential for Endometrial Function during Early Pregnancy. 
  • ARID1A and PGR proteins interact in the endometrium and reveal a positive correlation in endometriosis. 
  • ARID1A-mutated ovarian cancers depend on HDAC6 activity. 
  • ARID5B genetic polymorphisms contribute to racial disparities in the incidence and treatment outcome of childhood acute lymphoblastic leukemia. 
  • ASH1L Links Histone H3 Lysine 36 Dimethylation to MLL Leukemia. 
  • ATDC/TRIM29 phosphorylation by ATM/MAPKAP kinase 2 mediates radioresistance in pancreatic cancer cells. 
  • ATM activation in normal human tissues and testicular cancer. 
  • ATM binds to beta-adaptin in cytoplasmic vesicles. 
  • ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway. 
  • ATM polymorphisms predict severe radiation pneumonitis in patients with non-small cell lung cancer treated with definitive radiation therapy. 
  • ATM regulates a DNA damage response posttranscriptional RNA operon in lymphocytes. 
  • ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS. 
  • ATM--a key determinant of multiple cellular responses to irradiation. 
  • ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage. 
  • ATM-dependent suppression of stress signaling reduces vascular disease in metabolic syndrome. 
  • ATM: genome stability, neuronal development, and cancer cross paths. 
  • ATR/ATM-mediated phosphorylation of human Rad17 is required for genotoxic stress responses. 
  • Aberrant splicing of the TSG101 tumor suppressor gene in human breast and ovarian cancers. 
  • Abh and AbrB control of Bacillus subtilis antimicrobial gene expression. 
  • Abnormal mouse lung alveolarization caused by Smad3 deficiency is a developmental antecedent of centrilobular emphysema. 
  • Absence of truncating BRIP1 mutations in chromosome 17q-linked hereditary prostate cancer families. 
  • Acinar cell carcinoma of the pancreas: new genetic and treatment insights into a rare malignancy. 
  • Activated signal transducer and activator of transcription (STAT) 3: localization in focal adhesions and function in ovarian cancer cell motility. 
  • Activation of MEF2 by muscle activity is mediated through a calcineurin-dependent pathway. 
  • Activation of TLX3 and NKX2-5 in t(5;14)(q35;q32) T-cell acute lymphoblastic leukemia by remote 3'-BCL11B enhancers and coregulation by PU.1 and HMGA1. 
  • Activation of an EDS1-mediated R-gene pathway in the snc1 mutant leads to constitutive, NPR1-independent pathogen resistance. 
  • Activation of src-family tyrosine kinases by LPS regulates cytokine production in dendritic cells by controlling AP-1 formation. 
  • Activation of the 9E3/cCAF chemokine by phorbol esters occurs via multiple signal transduction pathways that converge to MEK1/ERK2 and activate the Elk1 transcription factor. 
  • Activation of the ATM kinase by ionizing radiation and phosphorylation of p53. 
  • Activator protein-1 has an essential role in pancreatic cancer cells and is regulated by a novel Akt-mediated mechanism. 
  • Adaptive mechanisms that preserve cardiac function in mice without myoglobin. 
  • Adenovirus E1A, simian virus 40 tumor antigen, and human papillomavirus E7 protein share the capacity to disrupt the interaction between transcription factor E2F and the retinoblastoma gene product. 
  • Adenovirus-mediated transfer of CCAAT/enhancer-binding protein-alpha identifies a dominant antiproliferative role for this isoform in hepatocytes. 
  • Adipose-specific deletion of TFAM increases mitochondrial oxidation and protects mice against obesity and insulin resistance. 
  • Adult patients with de novo acute myeloid leukemia and t(9; 11)(p22; q23) have a superior outcome to patients with other translocations involving band 11q23: a cancer and leukemia group B study. 
  • Advances in targeted genome editing. 
  • Advances in the understanding and treatment of human severe combined immunodeficiency. 
  • African-derived genetic polymorphisms in TNFAIP3 mediate risk for autoimmunity. 
  • Aged human muscle demonstrates an altered gene expression profile consistent with an impaired response to exercise. 
  • Akt phosphorylates and activates HSF-1 independent of heat shock, leading to Slug overexpression and epithelial-mesenchymal transition (EMT) of HER2-overexpressing breast cancer cells. 
  • All cyclophilins and FK506 binding proteins are, individually and collectively, dispensable for viability in Saccharomyces cerevisiae. 
  • Allele-specific regulation of TCR beta variable gene segment chromatin structure. 
  • Allelic diversity in the TGFB1 regulatory region: characterization of novel functional single nucleotide polymorphisms. 
  • Alpha-2 macroglobulin in Alzheimer's disease: a marker of neuronal injury through the RCAN1 pathway. 
  • Alteration of NF-kappa B p50 DNA binding kinetics by S-nitrosylation. 
  • Altered T-dependent antigen responses and development of autoimmune symptoms in mice lacking E2A in T lymphocytes. 
  • Alternative translation initiation site usage results in two structurally distinct forms of Pit-1. 
  • Amino acid changes in Xrs2p, Dun1p, and Rfa2p that remove the preferred targets of the ATM family of protein kinases do not affect DNA repair or telomere length in Saccharomyces cerevisiae. 
  • Amplification and high-level expression of heat shock protein 90 marks aggressive phenotypes of human epidermal growth factor receptor 2 negative breast cancer. 
  • An ATM/Chk2-mediated DNA damage-responsive signaling pathway suppresses Epstein-Barr virus transformation of primary human B cells. 
  • An ERCC4 regulatory variant predicts grade-3 or -4 toxicities in patients with advanced non-small cell lung cancer treated by platinum-based therapy. 
  • An analysis of T cell intrinsic roles of E2A by conditional gene disruption in the thymus. 
  • An analysis of single nucleotide polymorphisms of 125 DNA repair genes in the Texas genome-wide association study of lung cancer with a replication for the XRCC4 SNPs. 
  • An anti-silencer- and SATB1-dependent chromatin hub regulates Rag1 and Rag2 gene expression during thymocyte development. 
  • An atypical RNA polymerase involved in RNA silencing shares small subunits with RNA polymerase II. 
  • An auxin-dependent distal organizer of pattern and polarity in the Arabidopsis root. 
  • An essential role for Mad homology domain 1 in the association of Smad3 with histone deacetylase activity*. 
  • An inhibitory region of the DNA-binding domain of thyroid hormone receptor blocks hormone-dependent transactivation. 
  • An integrated encyclopedia of DNA elements in the human genome. 
  • An intron facilitates activation of the calspermin gene by the testis-specific transcription factor CREM tau. 
  • An oligonucleotide decoy for transcription factor E2F inhibits mesangial cell proliferation in vitro. 
  • An unexpected alliance between stress responses to drive oncogenesis. 
  • Anabolic function of the type II isozyme of hexokinase in hepatic lipid synthesis. 
  • Analysis of DNA mismatch repair proteins in human medulloblastoma. 
  • Analysis of microsatellite mutations in the mitochondrial DNA of Saccharomyces cerevisiae. 
  • Analysis of novel and recurrent mutations responsible for the tricho-rhino-phalangeal syndromes. 
  • Analysis of single nucleotide polymorphisms and radiation sensitivity of the lung assessed with an objective radiologic endpoin. 
  • Analysis of the excision step in human DNA mismatch repair. 
  • Analysis of the role of E2A-encoded proteins in insulin gene transcription. 
  • Androgen and androgen receptor antagonist responsive primary African-American benign prostate epithelial cell line. 
  • Angiotensin II mobilizes spleen monocytes to promote the development of abdominal aortic aneurysm in Apoe-/- mice. 
  • Angiotensin II-induced hypertrophy of rat vascular smooth muscle is associated with increased 18 S rRNA synthesis and phosphorylation of the rRNA transcription factor, upstream binding factor. 
  • Ankrd11 is a chromatin regulator involved in autism that is essential for neural development. 
  • Antagonism between apolipoprotein AI regulatory protein 1, Ear3/COUP-TF, and hepatocyte nuclear factor 4 modulates apolipoprotein CIII gene expression in liver and intestinal cells. 
  • Antagonism of SET using OP449 enhances the efficacy of tyrosine kinase inhibitors and overcomes drug resistance in myeloid leukemia. 
  • Anthrabenzoxocinones from Streptomyces sp. as liver X receptor ligands and antibacterial agents. 
  • Antibody response to a T-dependent antigen requires B cell expression of complement receptors. 
  • Antiestrogen can establish nonproductive receptor complexes and alter chromatin structure at target enhancers. 
  • Apolipoprotein E and peptide mimetics modulate inflammation by binding the SET protein and activating protein phosphatase 2A. 
  • Aptamers: an emerging class of therapeutics. 
  • Arabidopsis DDB1-CUL4 ASSOCIATED FACTOR1 forms a nuclear E3 ubiquitin ligase with DDB1 and CUL4 that is involved in multiple plant developmental processes. 
  • Arabidopsis SNI1 and RAD51D regulate both gene transcription and DNA recombination during the defense response. 
  • Armadillo coactivates transcription driven by the product of the Drosophila segment polarity gene dTCF. 
  • Aromatic hydrocarbon receptor interaction with the retinoblastoma protein potentiates repression of E2F-dependent transcription and cell cycle arrest. 
  • Assembly and molecular activities of the MutS tetramer. 
  • Assessing transcription factor motif drift from noisy decoy sequences. 
  • Assessment of autoantibodies to meningioma in a population-based study. 
  • Association and interactions between DNA repair gene polymorphisms and adult glioma. 
  • Association between XPF polymorphisms and cancer risk: a meta-analysis. 
  • Association between single nucleotide polymorphisms in ERCC4 and risk of squamous cell carcinoma of the head and neck. 
  • Association between the ERCC5 Asp1104His polymorphism and cancer risk: a meta-analysis. 
  • Association of XRCC1 polymorphisms and risk of differentiated thyroid carcinoma: a case-control analysis. 
  • Association of a functional tandem repeats in the downstream of human telomerase gene and lung cancer. 
  • Association of a p73 exon 2 G4C14-to-A4T14 polymorphism with risk of squamous cell carcinoma of the head and neck. 
  • Association of combined p73 and p53 genetic variants with tumor HPV16-positive oropharyngeal cancer. 
  • Association of genetic variation in IKZF1, ARID5B, and CEBPE and surrogates for early-life infections with the risk of acute lymphoblastic leukemia in Hispanic children. 
  • Associations between expression levels of nucleotide excision repair proteins in lymphoblastoid cells and risk of squamous cell carcinoma of the head and neck. 
  • Associations of Lys939Gln and Ala499Val polymorphisms of the XPC gene with cancer susceptibility: a meta-analysis. 
  • Ataxia telangiectasia mutant protein activates c-Abl tyrosine kinase in response to ionizing radiation. 
  • Ataxia telangiectasia-mutated and p53 are potential mediators of chloroquine-induced resistance to mammary carcinogenesis. 
  • Ataxia-telangiectasia group D complementing gene (ATDC) promotes lung cancer cell proliferation by activating NF-κB pathway. 
  • Atm deficiency affects both apoptosis and proliferation to augment Myc-induced lymphomagenesis. 
  • Atomic force microscopy captures the initiation of methyl-directed DNA mismatch repair. 
  • Attempted replication of 50 reported asthma risk genes identifies a SNP in RAD50 as associated with childhood atopic asthma. 
  • Aurora Kinase A is critical for the Nkx6.1 mediated β-cell proliferation pathway. 
  • Autoregulatory control of E2F1 expression in response to positive and negative regulators of cell cycle progression. 
  • Aven-dependent activation of ATM following DNA damage. 
  • B-lymphocyte development is regulated by the combined dosage of three basic helix-loop-helix genes, E2A, E2-2, and HEB. 
  • BLM-DNA2-RPA-MRN and EXO1-BLM-RPA-MRN constitute two DNA end resection machineries for human DNA break repair. 
  • BMP4 is essential for lens induction in the mouse embryo. 
  • Backbone dynamics of the monomeric lambda repressor denatured state ensemble under nondenaturing conditions. 
  • Bacterial plasmid partition machinery: a minimalist approach to survival. 
  • Bacteriophage T4 gene 41 helicase and gene 59 helicase-loading protein: a versatile couple with roles in replication and recombination. 
  • Bacteriophage T4 helicase loader protein gp59 functions as gatekeeper in origin-dependent replication in vivo. 
  • Bacteriophage T4 initiates bidirectional DNA replication through a two-step process. 
  • Bacteriophage T4 mutants hypersensitive to an antitumor agent that induces topoisomerase-DNA cleavage complexes. 
  • Balancing different types of actin polymerization at distinct sites: roles for Abelson kinase and Enabled. 
  • Basal LAT-diacylglycerol-RasGRP1 signals in T cells maintain TCRα gene expression. 
  • Basic residues in the nucleocapsid domain of Gag are critical for late events of HIV-1 budding. 
  • Behaviourally driven gene expression reveals song nuclei in hummingbird brain. 
  • Beryllofluoride mimics phosphorylation of NtrC and other bacterial response regulators. 
  • Bidirectional approaches for optogenetic regulation of gene expression in mammalian cells using Arabidopsis cryptochrome 2. 
  • Bidirectional excision in methyl-directed mismatch repair. 
  • Bimodal activation of SMC ATPase by intra- and inter-molecular interactions. 
  • Binding of HMG-I(Y) elicits structural changes in a silencer of the human beta-globin gene. 
  • Biochemical correlates of temozolomide sensitivity in pediatric solid tumor xenograft models. 
  • Biological Significance of Photoreceptor Photocycle Length: VIVID Photocycle Governs the Dynamic VIVID-White Collar Complex Pool Mediating Photo-adaptation and Response to Changes in Light Intensity. 
  • Biological activity of interleukin-10 in the central nervous system. 
  • Biomedicine. Insulin resistance takes a trip through the ER. 
  • Biphasic induction of immediate early gene expression accompanies activity-dependent angiogenesis and myofiber remodeling of rabbit skeletal muscle. 
  • Bisphenol A delays the perinatal chloride shift in cortical neurons by epigenetic effects on the Kcc2 promoter. 
  • Blood monocyte transcriptome and epigenome analyses reveal loci associated with human atherosclerosis. 
  • Blood vessels engineered from human cells. 
  • Bone formation by human postnatal bone marrow stromal stem cells is enhanced by telomerase expression. 
  • Bone morphogenetic protein 2 opposes Shh-mediated proliferation in cerebellar granule cells through a TIEG-1-based regulation of Nmyc. 
  • Brassinosteroid, gibberellin, and phytochrome signalling pathways impinge on a common transcription module in Arabidopsis 
  • Brassinosteroids: Multidimensional Regulators of Plant Growth, Development, and Stress Responses. 
  • C-terminal regions of the human telomerase catalytic subunit essential for in vivo enzyme activity. 
  • CARHSP1 is required for effective tumor necrosis factor alpha mRNA stabilization and localizes to processing bodies and exosomes. 
  • CBF, Myb, and Ets binding sites are important for activity of the core I element of the murine retrovirus SL3-3 in T lymphocytes. 
  • CDKN1C (p57) is a direct target of EZH2 and suppressed by multiple epigenetic mechanisms in breast cancer cells. 
  • CHD7 targets active gene enhancer elements to modulate ES cell-specific gene expression. 
  • COUGER--co-factors associated with uniquely-bound genomic regions. 
  • CRL4Mahj E3 ubiquitin ligase promotes neural stem cell reactivation. 
  • CTLA-4-Mediated inhibition of early events of T cell proliferation. 
  • Caenorhabditis elegans DNA mismatch repair gene msh-2 is required for microsatellite stability and maintenance of genome integrity. 
  • Calcineurin mutants render T lymphocytes resistant to cyclosporin A. 
  • Calcineurin target CrzA regulates conidial germination, hyphal growth, and pathogenesis of Aspergillus fumigatus. 
  • Calcineurin-NFAT signaling, together with GABP and peroxisome PGC-1{alpha}, drives utrophin gene expression at the neuromuscular junction. 
  • Calcineurin. Structure, function, and inhibition. 
  • Calcineurin: a central controller of signalling in eukaryotes. 
  • Calcium-Calmodulin-Calcineurin Signaling: A Globally Conserved Virulence Cascade in Eukaryotic Microbial Pathogens. 
  • Calcium-dependent gene regulation in myocyte hypertrophy and remodeling. 
  • Calmodulin-dependent protein kinase IV regulates nuclear export of Cabin1 during T-cell activation. 
  • Calspermin gene transcription is regulated by two cyclic AMP response elements contained in an alternative promoter in the calmodulin kinase IV gene. 
  • Carbonic anhydrase IX is a predictive marker of doxorubicin resistance in early-stage breast cancer independent of HER2 and TOP2A amplification. 
  • Cardiac repolarization: current knowledge, critical gaps, and new approaches to drug development and patient management. 
  • Casein kinase Iepsilon plays a functional role in the transforming growth factor-beta signaling pathway. 
  • Caspase-1-induced pyroptotic cell death. 
  • Caspase-3 cleavage links delta-catenin to the novel nuclear protein ZIFCAT. 
  • Cdc6 is regulated by E2F and is essential for DNA replication in mammalian cells. 
  • Cell biology: A BID for the pathway. 
  • Cell cycle. Checking two steps. 
  • Cell cycle: Flies teach an old dogma new tricks. 
  • Centromere identity in Drosophila is not determined in vivo by replication timing. 
  • Centromeres of human chromosomes. 
  • Changes in the expression of transcription factors ATF-2 and Fra-2 after axotomy and during regeneration in rat retinal ganglion cells. 
  • Characteristics of the interaction of a synthetic human tristetraprolin tandem zinc finger peptide with AU-rich element-containing RNA substrates. 
  • Characterization and expression of a rice RAD23 gene. 
  • Characterization of RanBP2-associated molecular components in neuroretina. 
  • Characterization of a cholesterol response element (CRE) in the promoter of the cholesteryl ester transfer protein gene: functional role of the transcription factors SREBP-1a, -2, and YY1. 
  • Characterization of a putative insulin-responsive element and its binding protein(s) in rat angiotensinogen gene promoter: regulation by glucose and insulin. 
  • Characterization of a zinc finger DNA-binding protein expressed specifically in Petunia petals and seedlings. 
  • Characterization of interactions between PinX1 and human telomerase subunits hTERT and hTR. 
  • Characterization of neo-centromeres in marker chromosomes lacking detectable alpha-satellite DNA. 
  • Characterization of substrate phosphorylation and use of calmodulin mutants to address implications from the enzyme crystal structure of calmodulin-dependent protein kinase I. 
  • Characterization of the PC4 binding domain and its interactions with HNF4alpha. 
  • Characterization of the absence of an unique DNA-binding protein in senescent but not in their young growing and nongrowing counterparts provides the means to mark the final stage of the cellular aging process. 
  • Characterization of the mouse FTZ-F1 gene, which encodes a key regulator of steroid hydroxylase gene expression. 
  • Characterization of the porcine ATM gene: towards the generation of a novel non-murine animal model for Ataxia-Telangiectasia. 
  • Characterization of the rat type III hexokinase gene promoter. A functional octamer 1 motif is critical for basal promoter activity. 
  • Characterization of transcriptional activation and DNA-binding functions in the hinge region of the vitamin D receptor. 
  • Characterizing Watson-Crick versus Hoogsteen Base Pairing in a DNA-Protein Complex Using Nuclear Magnetic Resonance and Site-Specifically 13C- and 15N-Labeled DNA. 
  • Characterizing the developmental pathways TTF-1, NKX2-8, and PAX9 in lung cancer. 
  • Checkpoint signals in grasshopper meiosis are sensitive to microtubule attachment, but tension is still essential. 
  • Chemokine production by G protein-coupled receptor activation in a human mast cell line: roles of extracellular signal-regulated kinase and NFAT. 
  • Chloroquine improves survival and hematopoietic recovery after lethal low-dose-rate radiation. 
  • Chromatin association of rad17 is required for an ataxia telangiectasia and rad-related kinase-mediated S-phase checkpoint in response to low-dose ultraviolet radiation. 
  • Chromatin conformation of yeast centromeres 
  • Chromium (VI) activates ataxia telangiectasia mutated (ATM) protein. Requirement of ATM for both apoptosis and recovery from terminal growth arrest. 
  • Chronic inhibition of cyclic GMP phosphodiesterase 5A prevents and reverses cardiac hypertrophy. 
  • Chronic oxidative stress promotes GADD34-mediated phosphorylation of the TAR DNA-binding protein TDP-43, a modification linked to neurodegeneration. 
  • Circular RNA circEsyt2 regulates vascular smooth muscle cell remodeling via splicing regulation. 
  • Circular transcripts of the testis-determining gene Sry in adult mouse testis. 
  • Cisplatin and adriamycin resistance are associated with MutLalpha and mismatch repair deficiency in an ovarian tumor cell line. 
  • Clinical Characteristics, Oral Anticoagulation Patterns, and Outcomes of Medicaid Patients With Atrial Fibrillation: Insights From the Outcomes Registry for Better Informed Treatment of Atrial Fibrillation (ORBIT-AF I) Registry. 
  • Clinical and Genetic Risk Prediction of Subsequent CNS Tumors in Survivors of Childhood Cancer: A Report From the COG ALTE03N1 Study. 
  • Clinical application of whole-genome sequencing in patients with primary immunodeficiency. 
  • Clinical heterogeneity in lymphoedema-distichiasis with FOXC2 truncating mutations. 
  • Clinical significance of tumor-associated inflammatory cells in metastatic neuroblastoma. 
  • Clinico-pathological description of three paediatric medulloblastoma cases with MLL2/3 gene mutations. 
  • Cloning and characterization of a novel endothelial promoter of the human CYP19 (aromatase P450) gene that is up-regulated in breast cancer tissue. 
  • Cloning and characterization of the major promoter of the human protein kinase C beta gene. Regulation by phorbol esters. 
  • Cloning and characterization of two yeast genes encoding members of the CCCH class of zinc finger proteins: zinc finger-mediated impairment of cell growth. 
  • Cloning of an NF-kappa B subunit which stimulates HIV transcription in synergy with p65. 
  • Cloning of the Arabidopsis clock gene TOC1, an autoregulatory response regulator homolog 
  • Coactivation of liver receptor homologue-1 by peroxisome proliferator-activated receptor gamma coactivator-1alpha on aromatase promoter II and its inhibition by activated retinoid X receptor suggest a novel target for breast-specific antiestrogen therapy. 
  • Cocaine shapes chromatin landscapes via Tet1. 
  • Cohesin: it's not just for chromosomes anymore. 
  • Collaborative interactions between MEF-2 and Sp1 in muscle-specific gene regulation. 
  • Colon cancer with microsatellite instability in a 13-year-old Hispanic male. 
  • Colonial differentiation in Streptomyces coelicolor depends on translation of a specific codon within the adpA gene. 
  • Combined effects of the p53 and p73 polymorphisms on lung cancer risk. 
  • Combined effects of the p53 codon 72 and p73 G4C14-to-A4T14 polymorphisms on the risk of HPV16-associated oral cancer in never-smokers. 
  • Combined expression of A1 and A20 achieves optimal protection of renal proximal tubular epithelial cells. 
  • Combined p53-related genetic variants together with HPV infection increase oral cancer risk. 
  • Combined targeting of SET and tyrosine kinases provides an effective therapeutic approach in human T-cell acute lymphoblastic leukemia. 
  • Common variants at 7p21 are associated with frontotemporal lobar degeneration with TDP-43 inclusions. 
  • Comparative Molecular Analysis of Gastrointestinal Adenocarcinomas. 
  • Comparative value of tumour grade, hormonal receptors, Ki-67, HER-2 and topoisomerase II alpha status as predictive markers in breast cancer patients treated with neoadjuvant anthracycline-based chemotherapy. 
  • Comparison of human and Xenopus GATA-2 promoters. 
  • Complete DiGeorge syndrome associated with CHD7 mutation. 
  • Complexity of CNC transcription factors as revealed by gene targeting of the Nrf3 locus. 
  • Compromised CDK1 activity sensitizes BRCA-proficient cancers to PARP inhibition. 
  • Computational tools for understanding sequence variability in recombination signals. 
  • Concentration and desalting of protein samples for mass spectrometry analysis. 
  • Concise review: role of DEK in stem/progenitor cell biology. 
  • Condensin and cohesin display different arm conformations with characteristic hinge angles. 
  • Conditional telomerase induction causes proliferation of hair follicle stem cells. 
  • Conformational changes of purine repressor DNA-binding domain upon complexation with DNA. 
  • Conformational plasticity of the coiled-coil domain of BmrR is required for bmr operator binding: the structure of unliganded BmrR. 
  • Consensus and variant cAMP-regulated enhancers have distinct CREB-binding properties. 
  • Conserved organization of centromeric chromatin in flies and humans. 
  • Constitutive Sp1 activity is essential for differential constitutive expression of vascular endothelial growth factor in human pancreatic adenocarcinoma. 
  • Constitutive disease resistance requires EDS1 in the Arabidopsis mutants cpr1 and cpr6 and is partially EDS1-dependent in cpr5. 
  • Contribution of a buried hydrogen bond to lambda repressor folding kinetics. 
  • Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1. 
  • Controlling lymphopoiesis with a combinatorial E-protein code. 
  • Convergence of the fanconi anemia and ataxia telangiectasia signaling pathways. 
  • Convergent effects of mouse Pet-1 deletion and human PET-1 variation on amygdala fear and threat processing. 
  • Cooperation among multiple transcription factors is required for access to minimal T-cell receptor alpha-enhancer chromatin in vivo. 
  • Cooperation between core binding factor and adjacent promoter elements contributes to the tissue-specific expression of interleukin-3. 
  • Cooperation of Sp1 and p300 in the induction of the CDK inhibitor p21WAF1/CIP1 during NGF-mediated neuronal differentiation. 
  • Coordinated activation of candidate proto-oncogenes and cancer testes antigens via promoter demethylation in head and neck cancer and lung cancer. 
  • Coordination and processing of DNA ends during double-strand break repair: the role of the bacteriophage T4 Mre11/Rad50 (MR) complex. 
  • Coordination of replication and transcription along a Drosophila chromosome. 
  • Correlation between germline mutations in MMR genes and microsatellite instability in ovarian cancer specimens. 
  • Correspondence regarding: TDP-43 proteinopathy and motor neuron disease in chronic traumatic encephalopathy. J Neuropathol Exp Neurol 2010:69;918-29. 
  • Cowpox virus and other members of the orthopoxvirus genus interfere with the regulation of NF-kappaB activation. 
  • Creation of an active estrogen-responsive element by a single base change in the flanking sequence of a cellular oncogene: a possible mechanism for hormonal carcinogenesis? 
  • Creation of human tumour cells with defined genetic elements. 
  • Cross-ancestry genome-wide meta-analysis of 61,047 cases and 947,237 controls identifies new susceptibility loci contributing to lung cancer. 
  • Crystal structure of LacI member, PurR, bound to DNA: minor groove binding by alpha helices. 
  • Crystal structure of MtaN, a global multidrug transporter gene activator. 
  • Crystal structure of the human LRH-1 DBD-DNA complex reveals Ftz-F1 domain positioning is required for receptor activity. 
  • Crystal structure of the phage T4 recombinase UvsX and its functional interaction with the T4 SF2 helicase UvsW. 
  • Crystal structures of SarA, a pleiotropic regulator of virulence genes in S. aureus. 
  • Crystallization and preliminary X-ray studies on the co-repressor binding domain of the Escherichia coli purine repressor. 
  • Crystallization of a complex of cro repressor with a 17 base-pair operator. 
  • Cutting edge: Cytosolic bacterial DNA activates the inflammasome via Aim2. 
  • Cyclic AMP-dependent protein kinase regulates pseudohyphal differentiation in Saccharomyces cerevisiae. 
  • Cyclophilin A and Ess1 interact with and regulate silencing by the Sin3-Rpd3 histone deacetylase. 
  • Cyclophilin-related protein RanBP2 acts as chaperone for red/green opsin. 
  • Cytokine signals through STAT3 promote expression of granulocyte secondary granule proteins in 32D cells. 
  • Cytokine transcriptional events during helper T cell subset differentiation. 
  • DDB1 functions as a linker to recruit receptor WD40 proteins to CUL4-ROC1 ubiquitin ligases. 
  • DEK is required for homologous recombination repair of DNA breaks. 
  • DEK oncogene expression during normal hematopoiesis and in Acute Myeloid Leukemia (AML). 
  • DEK proto-oncogene expression interferes with the normal epithelial differentiation program. 
  • DEK regulates hematopoietic stem engraftment and progenitor cell proliferation. 
  • DHFR/MSH3 amplification in methotrexate-resistant cells alters the hMutSalpha/hMutSbeta ratio and reduces the efficiency of base-base mismatch repair. 
  • DNA and RNA topoisomerase activities of Top3β are promoted by mediator protein Tudor domain-containing protein 3. 
  • DNA chain length dependence of formation and dynamics of hMutSalpha.hMutLalpha.heteroduplex complexes. 
  • DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation. 
  • DNA damage responses: mechanisms and roles in human disease: 2007 G.H.A. Clowes Memorial Award Lecture. 
  • DNA mismatch repair: functions and mechanisms. 
  • DNA mismatches reveal conformational penalties in protein-DNA recognition. 
  • DNA polymerase zeta introduces multiple mutations when bypassing spontaneous DNA damage in Saccharomyces cerevisiae. 
  • DNA repair gene ERCC1 and ERCC2/XPD polymorphisms and risk of squamous cell carcinoma of the head and neck. 
  • DNA repair gene XPC genotypes/haplotypes and risk of lung cancer in a Chinese population. 
  • DNA repair gene XPD polymorphism and lung cancer risk: a meta-analysis. 
  • DNA repair gene XRCC3 241Met variant is not associated with risk of cutaneous malignant melanoma. 
  • DNA-XPA interactions: a (31)P NMR and molecular modeling study of dCCAATAACC association with the minimal DNA-binding domain (M98-F219) of the nucleotide excision repair protein XPA. 
  • DNA-dependent activation of the hMutSalpha ATPase. 
  • Daily humidity oscillation regulates the circadian clock to influence plant physiology. 
  • Daughter-specific transcription factors regulate cell size control in budding yeast. 
  • Dax1 regulates testis cord organization during gonadal differentiation. 
  • De Novo Mutations in SON Disrupt RNA Splicing of Genes Essential for Brain Development and Metabolism, Causing an Intellectual-Disability Syndrome. 
  • Defective dendritic cell maturation in a child with nucleotide excision repair deficiency and CD4 lymphopenia. 
  • Defective mesonephric cell migration is associated with abnormal testis cord development in C57BL/6J XY(Mus domesticus) mice. 
  • Defective signaling in a subpopulation of CD4(+) T cells in the absence of Ca(2+)/calmodulin-dependent protein kinase IV. 
  • Defects of the heart, eye, and megakaryocytes in peroxisome proliferator activator receptor-binding protein (PBP) null embryos implicate GATA family of transcription factors. 
  • Defining the genotypic and phenotypic spectrum of X-linked MSL3-related disorder. 
  • Definition of the critical cellular components which distinguish between hormone and antihormone activated progesterone receptor. 
  • Deletion of Y chromosome sequences located outside the testis determining region can cause XY female sex reversal. 
  • Deltex1 redirects lymphoid progenitors to the B cell lineage by antagonizing Notch1. 
  • Dependence of the regulation of telomere length on the type of subtelomeric repeat in the yeast Saccharomyces cerevisiae. 
  • Derepression of BDNF transcription involves calcium-dependent phosphorylation of MeCP2. 
  • Design, Assembly, and Characterization of TALE-Based Transcriptional Activators and Repressors. 
  • Destruction of Myc by ubiquitin-mediated proteolysis: cancer-associated and transforming mutations stabilize Myc. 
  • Detailed analysis of gene expression during development of T cell lineages in the thymus. 
  • Detection of DNA looping due to simultaneous interaction of a DNA-binding protein with two spatially separated binding sites on DNA. 
  • Development of DNA Vaccine Targeting E6 and E7 Proteins of Human Papillomavirus 16 (HPV16) and HPV18 for Immunotherapy in Combination with Recombinant Vaccinia Boost and PD-1 Antibody. 
  • Developmental biology informs cancer: the emerging role of the hedgehog signaling pathway in upper gastrointestinal cancers. 
  • Developmental control of gene copy number by repression of replication initiation and fork progression. 
  • Developmental control of the DNA replication and transcription programs. 
  • Diagnosis of 22q11.2 deletion syndrome and artemis deficiency in two children with T-B-NK+ immunodeficiency. 
  • Dietary isothiocyanate-induced apoptosis via thiol modification of DNA topoisomerase IIα. 
  • Differences in the anatomic distribution of immediate-early gene expression in amygdala and angular bundle kindling development. 
  • Different dimerization activities of alpha and beta thyroid hormone receptor isoforms. 
  • Differential and simultaneous adenosine di- and triphosphate binding by MutS. 
  • Differential effects of CD30 activation in anaplastic large cell lymphoma and Hodgkin disease cells. 
  • Differential effects of nitric oxide-mediated S-nitrosylation on p50 and c-jun DNA binding. 
  • Differential expression of p63 isoforms in female reproductive organs. 
  • Differential functions for the transcription factor E2A in positive and negative gene regulation in pre-B lymphocytes. 
  • Differential gene expression of blood-derived cell lines in familial combined hyperlipidemia. 
  • Differential regulation of vascular cell adhesion molecule 1 gene expression by specific NF-kappa B subunits in endothelial and epithelial cells. 
  • Differential requirement for STAT by gain-of-function and wild-type receptor tyrosine kinase Torso in Drosophila. 
  • Differential specificities and simultaneous occupancy of human MutSalpha nucleotide binding sites. 
  • Differentially labeled mutant oligonucleotides for analysis of protein-DNA interactions. 
  • Dimerization and ubiquitin mediated recruitment of A20, a complex deubiquitinating enzyme. 
  • Dimerization of NF-KB2 with RelA(p65) regulates DNA binding, transcriptional activation, and inhibition by an I kappa B-alpha (MAD-3). 
  • Dinucleotide polymorphism of p73 gene is associated with a reduced risk of lung cancer in a Chinese population. 
  • Direct interactions between autoantigen La and human immunodeficiency virus leader RNA. 
  • Direct visualization of asymmetric adenine-nucleotide-induced conformational changes in MutL alpha. 
  • Directing visceral white adipocyte precursors to a thermogenic adipocyte fate improves insulin sensitivity in obese mice. 
  • Disappearance of the telomere dysfunction-induced stress response in fully senescent cells. 
  • Disrupted gonadogenesis and male-to-female sex reversal in Pod1 knockout mice. 
  • Disruption of PAX6 function in mice homozygous for the Pax6Sey-1Neu mutation produces abnormalities in the early development and regionalization of the diencephalon. 
  • Dissecting the regulatory architecture of gene expression QTLs. 
  • Dissection of the molecular circuitry controlling virulence in Francisella tularensis. 
  • Dissociation among in vitro telomerase activity, telomere maintenance, and cellular immortalization. 
  • Dissociation of radiation-induced phosphorylation of replication protein A from the S-phase checkpoint. 
  • Distinct Epigenetic Effects of Tobacco Smoking in Whole Blood and among Leukocyte Subtypes. 
  • Distinct MutS DNA-binding modes that are differentially modulated by ATP binding and hydrolysis. 
  • Distinct combinations of NF-kappa B subunits determine the specificity of transcriptional activation. 
  • Distinct functional domains of Nbs1 modulate the timing and magnitude of ATM activation after low doses of ionizing radiation. 
  • Distinct functions of Nijmegen breakage syndrome in ataxia telangiectasia mutated-dependent responses to DNA damage. 
  • Distinct mesodermal signals, including BMPs from the septum transversum mesenchyme, are required in combination for hepatogenesis from the endoderm. 
  • Distinct nuclear proteins competing for an overlapping sequence of cyclic adenosine monophosphate and negative regulatory elements regulate tissue-specific mouse renin gene expression. 
  • Distinct roles for c-Myb and core binding factor/polyoma enhancer-binding protein 2 in the assembly and function of a multiprotein complex on the TCR delta enhancer in vivo. 
  • Distinguishing direct versus indirect transcription factor-DNA interactions. 
  • Diterpenoid, steroid, and triterpenoid agonists of liver X receptors from diversified terrestrial plants and marine sources. 
  • Divergent vascular mechanisms downstream of Sry establish the arterial system in the XY gonad. 
  • Diverse genetic-driven immune landscapes dictate tumor progression through distinct mechanisms. 
  • Do germinal centers have a role in the generation of lymphomas? 
  • Domain structure and DNA binding regions of beta protein from bacteriophage lambda. 
  • Domains of the adenovirus E1A protein required for oncogenic activity are also required for dissociation of E2F transcription factor complexes. 
  • Down-regulation of neu/HER-2 by interferon-gamma in prostate cancer cells. 
  • Drosophila E2f2 promotes the conversion from genomic DNA replication to gene amplification in ovarian follicle cells. 
  • Drosophila TFIID binds to a conserved downstream basal promoter element that is present in many TATA-box-deficient promoters. 
  • Drosophila Tcf and Groucho interact to repress Wingless signalling activity. 
  • Dual roles of modulatory calcineurin-interacting protein 1 in cardiac hypertrophy. 
  • Dynamic perfluorinated gas MRI reveals abnormal ventilation despite normal FEV1 in cystic fibrosis. 
  • Dynamics of BAF-Polycomb complex opposition on heterochromatin in normal and oncogenic states. 
  • Dysregulation of hedgehog signalling predisposes to synovial chondromatosis. 
  • Dystonia with and without deafness is caused by TIMM8A mutation. 
  • E1A-mediated inhibition of myogenesis correlates with a direct physical interaction of E1A12S and basic helix-loop-helix proteins. 
  • E2F3 activity is regulated during the cell cycle and is required for the induction of S phase. 
  • E2F4-RB and E2F4-p107 complexes suppress gene expression by transforming growth factor beta through E2F binding sites. 
  • ELF3 is a repressor of androgen receptor action in prostate cancer cells. 
  • ER Stress Sensor XBP1 Controls Anti-tumor Immunity by Disrupting Dendritic Cell Homeostasis. 
  • ERCC1 and ERCC2 polymorphisms predict clinical outcomes of oxaliplatin-based chemotherapies in gastric and colorectal cancer: a systemic review and meta-analysis. 
  • ERCC1 and ERCC2 variants predict survival in gastric cancer patients. 
  • ERCC1 protein expression is associated with differential survival in oropharyngeal head and neck squamous cell carcinoma. 
  • ETS transcription factors regulate an enhancer activity in the third intron of TNF-alpha. 
  • EZH2 regulates the transcription of estrogen-responsive genes through association with REA, an estrogen receptor corepressor. 
  • Early de novo DNA methylation and prolonged demethylation in the muscle lineage. 
  • Early elicitor induction in members of a novel multigene family coding for highly related RING-H2 proteins in Arabidopsis thaliana 
  • Early retinal neurodegeneration and impaired Ran-mediated nuclear import of TDP-43 in progranulin-deficient FTLD. 
  • Ectopic expression of interferon regulatory factor-1 promotes human breast cancer cell death and results in reduced expression of survivin. 
  • Ectopic expression of transcription factor NF-E2 alters the phenotype of erythroid and monoblastoid cells. 
  • Effect of FTY720 on the SET-PP2A complex in acute myeloid leukemia; SET binding drugs have antagonistic activity. 
  • Effects of base excision repair gene polymorphisms on pancreatic cancer survival. 
  • Effects of hexavalent chromium on the survival and cell cycle distribution of DNA repair-deficient S. cerevisiae. 
  • Effects of mismatch repair and Hpr1 on transcription-stimulated mitotic recombination in the yeast Saccharomyces cerevisiae. 
  • Effects of nickel(II) on nuclear protein binding to DNA in intact mammalian cells. 
  • Effects of rearrangement and allelic exclusion of JJAZ1/SUZ12 on cell proliferation and survival. 
  • Egr-1 is activated by 17beta-estradiol in MCF-7 cells by mitogen-activated protein kinase-dependent phosphorylation of ELK-1. 
  • Ehd4 is required to attain normal prepubertal testis size but dispensable for fertility in male mice. 
  • Eight common genetic variants associated with serum DHEAS levels suggest a key role in ageing mechanisms. 
  • Electrical stimulation of neonatal cardiac myocytes activates the NFAT3 and GATA4 pathways and up-regulates the adenylosuccinate synthetase 1 gene. 
  • Elevated LRRK2 autophosphorylation in brain-derived and peripheral exosomes in LRRK2 mutation carriers. 
  • Elevated hepatocyte levels of the Forkhead box A2 (HNF-3beta) transcription factor cause postnatal steatosis and mitochondrial damage. 
  • Embryonal central nervous system neoplasms arising in infants and young children: a pediatric brain tumor consortium study. 
  • Embryonic expression of Lim-1, the mouse homolog of Xenopus Xlim-1, suggests a role in lateral mesoderm differentiation and neurogenesis. 
  • Endometrial epithelial ARID1A is critical for uterine gland function in early pregnancy establishment. 
  • Endothelial healing in vein grafts: proliferative burst unimpaired by genetic therapy of neointimal disease. 
  • Engineering synthetic TALE and CRISPR/Cas9 transcription factors for regulating gene expression. 
  • Enhanced T cell responses due to diacylglycerol kinase zeta deficiency. 
  • Enhancer analysis of the mouse HNF-3 beta gene: regulatory elements for node/notochord and floor plate are independent and consist of multiple sub-elements. 
  • Enhancer-origin interaction in plasmid R6K involves a DNA loop mediated by initiator protein. 
  • Enhancing immunogenicity by CpG DNA. 
  • Environmental estrogens differentially engage the histone methyltransferase EZH2 to increase risk of uterine tumorigenesis. 
  • Epigenetic Silencing of Recombinant Adeno-associated Virus Genomes by NP220 and the HUSH Complex. 
  • Epigenetic dysregulation of Oxtr in Tet1-deficient mice has implications for neuropsychiatric disorders. 
  • Epigenetic inactivation of RUNX3 in microsatellite unstable sporadic colon cancers. 
  • Epigenome-Wide Association Study for All-Cause Mortality in a Cardiovascular Cohort Identifies Differential Methylation in Castor Zinc Finger 1 (CASZ1). 
  • Epithelial-mesenchymal transitions and hepatocarcinogenesis. 
  • Epstein-Barr virus induces global changes in cellular mRNA isoform usage that are important for the maintenance of latency. 
  • Erythroid AP-1/NF-E2 elements vary in their response to NF-E2. 
  • Erythroid transcription factor NF-E2 coordinates hemoglobin synthesis. 
  • Erythroid transcription factor NF-E2 is a haematopoietic-specific basic-leucine zipper protein. 
  • Erythropoietin activates mitochondrial biogenesis and couples red cell mass to mitochondrial mass in the heart. 
  • Erythropoietin hypersensitivity in primary familial and congenital polycythemia: role of tyrosines Y285 and Y344 in erythropoietin receptor cytoplasmic domain. 
  • Escape from tolerance in the human X-linked autoimmunity-allergic disregulation syndrome and the Scurfy mouse. 
  • Escherichia coli biotin holoenzyme synthetase/bio repressor crystal structure delineates the biotin- and DNA-binding domains. 
  • Escherichia coli mutS-encoded protein binds to mismatched DNA base pairs. 
  • Escherichia coli purine repressor: key residues for the allosteric transition between active and inactive conformations and for interdomain signaling. 
  • Essential role for Smad3 in regulating MCP-1 expression and vascular inflammation. 
  • Evaluation of allelic strength of human TET2 mutations and cooperation between Tet2 knockdown and oncogenic Nras mutation. 
  • Evidence for association of SNPs in ABCB1 and CBR3, but not RAC2, NCF4, SLC28A3 or TOP2B, with chronic cardiotoxicity in a cohort of breast cancer patients treated with anthracyclines. 
  • Evidence for multiple roles for grainyhead-like 2 in the establishment and maintenance of human mucociliary airway epithelium.[corrected]. 
  • Evidence for the involvement of the Gli gene family in embryonic mouse lung development. 
  • Evidence from normal expression and targeted misexpression that bone morphogenetic protein (Bmp-4) plays a role in mouse embryonic lung morphogenesis. 
  • Evidence that Mothers-against-dpp-related 1 (Madr1) plays a role in the initiation and maintenance of spermatogenesis in the mouse. 
  • Evolving revascularization approaches for myocardial ischemia. 
  • Ex-vivo gene therapy of human vascular bypass grafts with E2F decoy: the PREVENT single-centre, randomised, controlled trial. 
  • Examination of the roles of Sgs1 and Srs2 helicases in the enforcement of recombination fidelity in Saccharomyces cerevisiae. 
  • Exome sequencing of liver fluke-associated cholangiocarcinoma. 
  • Exome sequencing reveals recurrent REV3L mutations in cisplatin-resistant squamous cell carcinoma of head and neck. 
  • Exome-wide Sequencing Shows Low Mutation Rates and Identifies Novel Mutated Genes in Seminomas. 
  • Expanding the Spectrum of BAF-Related Disorders: De Novo Variants in SMARCC2 Cause a Syndrome with Intellectual Disability and Developmental Delay. 
  • Expansion of adult beta-cell mass in response to increased metabolic demand is dependent on HNF-4alpha. 
  • Explicit equilibrium modeling of transcription-factor binding and gene regulation. 
  • Expression and assay of recombinant ATM. 
  • Expression and hormonal regulation of coactivator and corepressor genes. 
  • Expression and modification of Hox 2.1 protein in mouse embryos. 
  • Expression of A20 by dendritic cells preserves immune homeostasis and prevents colitis and spondyloarthritis. 
  • Expression of Sry, the mouse sex determining gene. 
  • Expression of TERT in early premalignant lesions and a subset of cells in normal tissues. 
  • Expression of a candidate sex-determining gene during mouse testis differentiation. 
  • Expression of a murine cytomegalovirus early-late protein in "latently" infected mice. 
  • Expression of five selected human mismatch repair genes simultaneously detected in normal and cancer cell lines by a nonradioactive multiplex reverse transcription-polymerase chain reaction. 
  • Expression of heme oxygenase-1 can determine cardiac xenograft survival. 
  • Expression of heterogeneous nuclear ribonucleoprotein A2/B1 changes with critical stages of mammalian lung development. 
  • Expression of human vitamin D receptor in Saccharomyces cerevisiae. Purification, properties, and generation of polyclonal antibodies. 
  • Expression of nucleotide excision repair genes and the risk for squamous cell carcinoma of the head and neck. 
  • Expression of osteocalcin and its transcriptional regulators core-binding factor alpha 1 and MSX2 in osteoid-forming tumours. 
  • Expression of telomerase reverse transcriptase (TERT) in malignant mesotheliomas. 
  • Expression of the E2F1 transcription factor overcomes type beta transforming growth factor-mediated growth suppression. 
  • Expression of utrophin A mRNA correlates with the oxidative capacity of skeletal muscle fiber types and is regulated by calcineurin/NFAT signaling. 
  • Expression, purification, and in vitro assays of mitochondrial single-stranded DNA-binding protein. 
  • Extra-placental expression of vascular endothelial growth factor receptor-1, (Flt-1) and soluble Flt-1 (sFlt-1), by peripheral blood mononuclear cells (PBMCs) in normotensive and preeclamptic pregnant women. 
  • FKBP12 is not required for the modulation of transforming growth factor beta receptor I signaling activity in embryonic fibroblasts and thymocytes. 
  • FKBP12 physically and functionally interacts with aspartokinase in Saccharomyces cerevisiae. 
  • FKBP12-rapamycin target TOR2 is a vacuolar protein with an associated phosphatidylinositol-4 kinase activity. 
  • FKF1 F-box protein mediates cyclic degradation of a repressor of CONSTANS in Arabidopsis 
  • Familial polycythemia due to truncations of the erythropoietin receptor. 
  • Fetal development of subcutaneous white adipose tissue is dependent on Zfp423. 
  • Fezf2 regulates telencephalic precursor differentiation from mouse embryonic stem cells. 
  • Fgf9 induces proliferation and nuclear localization of FGFR2 in Sertoli precursors during male sex determination. 
  • Flow linear dichroism and electron microscopic analysis of protein-DNA complexes of a mutant UvrB protein that binds to but cannot kink DNA. 
  • Folding kinetics of a fluorescent variant of monomeric lambda repressor. 
  • For whom the bird sings: context-dependent gene expression. 
  • Fragments of ATM which have dominant-negative or complementing activity. 
  • Frameshift intermediates in homopolymer runs are removed efficiently by yeast mismatch repair proteins. 
  • Frequency of LATE neuropathologic change across the spectrum of Alzheimer's disease neuropathology: combined data from 13 community-based or population-based autopsy cohorts. 
  • Frequency of mutations in mismatch repair genes in a population-based study of women with ovarian cancer. 
  • Frequent ATRX, CIC, FUBP1 and IDH1 mutations refine the classification of malignant gliomas. 
  • Frequent IGF2/H19 domain epigenetic alterations and elevated IGF2 expression in epithelial ovarian cancer. 
  • Frequent fusion of the JAZF1 and JJAZ1 genes in endometrial stromal tumors. 
  • Frequent overexpression of ETS-related gene-1 (ERG1) in prostate cancer transcriptome. 
  • From induction to conduction: how intrinsic transcriptional priming of extrinsic neuronal connectivity shapes neuronal identity. 
  • From man to fish: What can Zebrafish tell us about ApoL1 nephropathy? 
  • Functional Analysis and Fine Mapping of the 9p22.2 Ovarian Cancer Susceptibility Locus. 
  • Functional Analysis of the Bacteriophage T4 Rad50 Homolog (gp46) Coiled-coil Domain. 
  • Functional Variants in Notch Pathway Genes NCOR2, NCSTN, and MAML2 Predict Survival of Patients with Cutaneous Melanoma. 
  • Functional characterization of a unique liver gene promoter. 
  • Functional ecdysone receptor is the product of EcR and Ultraspiracle genes. 
  • Functional genetic variants of XRCC4 and ERCC1 predict survival of gastric cancer patients treated with chemotherapy by regulating the gene expression. 
  • Functional polymorphisms of base excision repair genes XRCC1 and APEX1 predict risk of radiation pneumonitis in patients with non-small cell lung cancer treated with definitive radiation therapy. 
  • Functional redundancy of the Nur77 and Nor-1 orphan steroid receptors in T-cell apoptosis. 
  • Functional replacement of the mouse E2A gene with a human HEB cDNA. 
  • Functional variations in the ATM gene and susceptibility to differentiated thyroid carcinoma. 
  • Functions of E2A-HEB heterodimers in T-cell development revealed by a dominant negative mutation of HEB. 
  • Functions of FKBP12 and mitochondrial cyclophilin active site residues in vitro and in vivo in Saccharomyces cerevisiae. 
  • Functions of fission yeast orp2 in DNA replication and checkpoint control. 
  • GLIS1 regulates trabecular meshwork function and intraocular pressure and is associated with glaucoma in humans. 
  • GNAS and KRAS Mutations Define Separate Progression Pathways in Intraductal Papillary Mucinous Neoplasm-Associated Carcinoma. 
  • GRHL2 coordinates regeneration of a polarized mucociliary epithelium from basal stem cells. 
  • Galpha12 and Galpha13 negatively regulate the adhesive functions of cadherin. 
  • Gamma-globin gene promoter elements required for interaction with globin enhancers. 
  • Gamma-radiation sensitivity and polymorphisms in RAD51L1 modulate glioma risk. 
  • Gastrostomy in oropharyngeal cancer patients with ERCC4 (XPF) germline variants. 
  • Gata3 loss leads to embryonic lethality due to noradrenaline deficiency of the sympathetic nervous system. 
  • Gene dosage-dependent embryonic development and proliferation defects in mice lacking the transcriptional integrator p300. 
  • Gene expression phenotypic models that predict the activity of oncogenic pathways. 
  • Gene profiling of canine B-cell lymphoma reveals germinal center and postgerminal center subtypes with different survival times, modeling human DLBCL. 
  • Gene therapy with an E2F transcription factor decoy inhibits cell cycle progression in rat anti-Thy 1 glomerulonephritis. 
  • Generalized dead-end elimination algorithms make large-scale protein side-chain structure prediction tractable: implications for protein design and structural genomics. 
  • Generation of S phase-dependent DNA double-strand breaks by Cr(VI) exposure: involvement of ATM in Cr(VI) induction of gamma-H2AX. 
  • Genes on the wing. 
  • Genetic DISC-section of regeneration in Drosophila. 
  • Genetic Determinants of Outcome in Intrahepatic Cholangiocarcinoma. 
  • Genetic analysis of sinonasal adenocarcinoma phenotypes: distinct alterations of histogenetic significance. 
  • Genetic and functional association of FAM5C with myocardial infarction. 
  • Genetic and phenotypic spectrum in the NONO-associated syndromic disorder. 
  • Genetic contribution to variation in DNA methylation at maternal smoking-sensitive loci in exposed neonates. 
  • Genetic engineering of a suboptimal islet graft with A20 preserves beta cell mass and function. 
  • Genetic interactions between Shox2 and Hox genes during the regional growth and development of the mouse limb. 
  • Genetic modeling of human rhabdomyosarcoma. 
  • Genetic polymorphisms in DNA base-excision repair genes ADPRT, XRCC1, and APE1 and the risk of squamous cell carcinoma of the head and neck. 
  • Genetic polymorphisms modify bladder cancer recurrence and survival in a USA population-based prognostic study. 
  • Genetic polymorphisms of ataxia telangiectasia mutated and breast cancer risk. 
  • Genetic polymorphisms of selected DNA repair genes, estrogen and progesterone receptor status, and breast cancer risk. 
  • Genetic requirements for spontaneous and transcription-stimulated mitotic recombination in Saccharomyces cerevisiae. 
  • Genetic variants in ERCC1 and XPC predict survival outcome of non-small cell lung cancer patients treated with platinum-based therapy. 
  • Genetic variants in Hippo pathway genes YAP1, TEAD1 and TEAD4 are associated with melanoma-specific survival. 
  • Genetic variants in p53-related genes confer susceptibility to second primary malignancy in patients with index squamous cell carcinoma of head and neck. 
  • Genetic variants of the ADPRT, XRCC1 and APE1 genes and risk of cutaneous melanoma. 
  • Genetic variants of the nonhomologous end joining gene LIG4 and severe radiation pneumonitis in nonsmall cell lung cancer patients treated with definitive radiotherapy. 
  • Genetic variants of the p53 and p73 genes jointly increase risk of second primary malignancies in patients after index squamous cell carcinoma of the head and neck. 
  • Genome engineering: the next genomic revolution. 
  • Genome-defined African ancestry is associated with distinct mutations and worse survival in patients with diffuse large B-cell lymphoma. 
  • Genome-wide analysis of STAT target genes: elucidating the mechanism of STAT-mediated oncogenesis. 
  • Genome-wide analysis of menin binding provides insights into MEN1 tumorigenesis. 
  • Genome-wide association and functional follow-up reveals new loci for kidney function. 
  • Genome-wide association study of bipolar I disorder in the Han Chinese population. 
  • Genome-wide identification of calcium-response factor (CaRF) binding sites predicts a role in regulation of neuronal signaling pathways. 
  • Genome-wide localization of replication factors. 
  • Genome-wide specificity of DNA binding, gene regulation, and chromatin remodeling by TALE- and CRISPR/Cas9-based transcriptional activators. 
  • Genomewide search for type 2 diabetes susceptibility genes in four American populations. 
  • Genomic correlates of variability in immune response to an oral cholera vaccine. 
  • Genomic distribution of CHD7 on chromatin tracks H3K4 methylation patterns. 
  • Genomic landscapes of breast fibroepithelial tumors. 
  • Genomic organization, expression, and localization of murine Ran-binding protein 2 (RanBP2) gene. 
  • Genomic structure and chromosomal localization of the novel ETS factor, PE-2 (ERF). 
  • Genotoxic stress regulates expression of the proto-oncogene Bcl6 in germinal center B cells. 
  • Genotypes and haplotypes of ERCC1 and ERCC2/XPD genes predict levels of benzo[a]pyrene diol epoxide-induced DNA adducts in cultured primary lymphocytes from healthy individuals: a genotype-phenotype correlation analysis. 
  • Germline genetic variants in men with prostate cancer and one or more additional cancers. 
  • Gibberellin signaling: biosynthesis, catabolism, and response pathways. 
  • Global Identification of EVI1 Target Genes in Acute Myeloid Leukemia. 
  • Global expression analysis of cancer/testis genes in uterine cancers reveals a high incidence of BORIS expression. 
  • Global identification of MLL2-targeted loci reveals MLL2's role in diverse signaling pathways. 
  • Glucocorticoid treatment alleviates dystrophic myofiber pathology by activation of the calcineurin/NF-AT pathway. 
  • Glucose down-regulates the expression of the peroxisome proliferator-activated receptor-alpha gene in the pancreatic beta -cell. 
  • Glutamine attenuates lung injury and improves survival after sepsis: role of enhanced heat shock protein expression. 
  • Glutamine attenuation of cell death and inducible nitric oxide synthase expression following inflammatory cytokine-induced injury is dependent on heat shock factor-1 expression. 
  • Glutamine enhances heat shock protein 70 expression via increased hexosamine biosynthetic pathway activity. 
  • Glutamine's protection against cellular injury is dependent on heat shock factor-1. 
  • Glutamine-mediated attenuation of cellular metabolic dysfunction and cell death after injury is dependent on heat shock factor-1 expression. 
  • Glutamine-mediated dual regulation of heat shock transcription factor-1 activation and expression. 
  • Glycine and a glycine dehydrogenase (GLDC) SNP as citalopram/escitalopram response biomarkers in depression: pharmacometabolomics-informed pharmacogenomics. 
  • Growth arrest and DNA damage-inducible protein GADD34 assembles a novel signaling complex containing protein phosphatase 1 and inhibitor 1. 
  • Growth factors regulate beta-catenin-mediated TCF-dependent transcriptional activation in fibroblasts during the proliferative phase of wound healing. 
  • Guanine repeat-containing sequences confer transcription-dependent instability in an orientation-specific manner in yeast. 
  • Guanylate binding proteins enable rapid activation of canonical and noncanonical inflammasomes in Chlamydia-infected macrophages. 
  • Guinea pig and bovine zeta-crystallins have distinct functional characteristics highlighting replacements in otherwise similar structures. 
  • Guttiferone I, a new prenylated benzophenone from Garcinia humilis as a liver X receptor ligand. 
  • HDAC4 promotes Pax7-dependent satellite cell activation and muscle regeneration. 
  • HDAC6 controls major cell response pathways to cytotoxic accumulation of protein aggregates. 
  • HIF-1alpha induces genetic instability by transcriptionally downregulating MutSalpha expression. 
  • HIV-1 induces renal epithelial dedifferentiation in a transgenic model of HIV-associated nephropathy. 
  • HMGB1: a multifunctional alarmin driving autoimmune and inflammatory disease. 
  • HNF-3 beta as a regulator of floor plate development. 
  • HNF-4alpha: from MODY to late-onset type 2 diabetes. 
  • HSP70 chaperones RNA-free TDP-43 into anisotropic intranuclear liquid spherical shells. 
  • HSV-1 amplicon vector-mediated expression of ATM cDNA and correction of the ataxia-telangiectasia cellular phenotype. 
  • Half-site arrangement of hybrid glucocorticoid and thyroid hormone response elements specifies thyroid hormone receptor complex binding to DNA and transcriptional activity. 
  • Haploinsufficiency of the transcription factors FOXC1 and FOXC2 results in aberrant ocular development. 
  • Haploinsufficient phenotypes in Bmp4 heterozygous null mice and modification by mutations in Gli3 and Alx4. 
  • Heat and cold denatured states of monomeric lambda repressor are thermodynamically and conformationally equivalent. 
  • Helix lap-joints as ion-binding sites: DNA-binding motifs and Ca-binding "EF hands" are related by charge and sequence reversal. 
  • Helix-loop-helix transcription factors E12 and E47 are not essential for skeletal or cardiac myogenesis, erythropoiesis, chondrogenesis, or neurogenesis. 
  • Heme Oxygenase-1/Carbon Monoxide System and Embryonic Stem Cell Differentiation and Maturation into Cardiomyocytes. 
  • Hepatocyte nuclear factor-4alpha mediates redox sensitivity of inducible nitric-oxide synthase gene transcription. 
  • Hereditary prostate cancer as a feature of Lynch syndrome. 
  • Heterodimerization among thyroid hormone receptor, retinoic acid receptor, retinoid X receptor, chicken ovalbumin upstream promoter transcription factor, and an endogenous liver protein. 
  • Hierarchical assembly and disassembly of a transcriptionally active RAG locus in CD4+CD8+ thymocytes. 
  • High XRCC1 protein expression is associated with poorer survival in patients with head and neck squamous cell carcinoma. 
  • High affinity for farnesyltransferase and alternative prenylation contribute individually to K-Ras4B resistance to farnesyltransferase inhibitors. 
  • High gene expression of TS1, GSTP1, and ERCC1 are risk factors for survival in patients treated with trimodality therapy for esophageal cancer. 
  • High level expression of a truncated chicken progesterone receptor in Escherichia coli. 
  • High mobility group box chromosomal protein 1 as a nuclear protein, cytokine, and potential therapeutic target in arthritis. 
  • High rate of CAD gene amplification in human cells deficient in MLH1 or MSH6. 
  • High-grade neuroendocrine carcinomas of the lung highly express enhancer of zeste homolog 2, but carcinoids do not. 
  • High-resolution genome-wide in vivo footprinting of diverse transcription factors in human cells. 
  • High-resolution solution structure of the beryllofluoride-activated NtrC receiver domain. 
  • Highly coordinated gene regulation in mouse skeletal muscle regeneration. 
  • HipBA-promoter structures reveal the basis of heritable multidrug tolerance. 
  • Histone H1 enhances the DNA binding activity of the transcription factor EmBP-1. 
  • Histone deacetylase 3 binds to and regulates the GCMa transcription factor. 
  • Histone lysine methyltransferase SDG8 is involved in brassinosteroid-regulated gene expression in Arabidopsis thaliana. 
  • Homoeo boxes and strings for the packaging of genes? 
  • Hormone signaling and fatty liver in females: analysis of estrogen receptor α mutant mice. 
  • How the zebrafish gets its stripes. 
  • Hsp90 governs echinocandin resistance in the pathogenic yeast Candida albicans via calcineurin. 
  • Human DNA-activated protein kinase (DNA-PK) is homologous to phosphatidylinositol kinases. 
  • Human MafG is a functional partner for p45 NF-E2 in activating globin gene expression. 
  • Human MutSalpha recognizes damaged DNA base pairs containing O6-methylguanine, O4-methylthymine, or the cisplatin-d(GpG) adduct. 
  • Human T-cell leukemia virus type 1 tax attenuates the ATM-mediated cellular DNA damage response. 
  • Human arteries engineered in vitro. 
  • Human equivalent of the mouse Nude/SCID phenotype: long-term evaluation of immunologic reconstitution after bone marrow transplantation. 
  • Human gamma-satellite DNA maintains open chromatin structure and protects a transgene from epigenetic silencing. 
  • Human immunodeficiency virus type 1 (HIV-1) induces activation of multiple STATs in CD4+ cells of lymphocyte or monocyte/macrophage lineages. 
  • Human immunodeficiency virus type 1 Vpr-binding protein VprBP, a WD40 protein associated with the DDB1-CUL4 E3 ubiquitin ligase, is essential for DNA replication and embryonic development. 
  • Human nucleotide excision repair protein XPA: NMR spectroscopic studies of an XPA fragment containing the ERCC1-binding region and the minimal DNA-binding domain (M59-F219). 
  • Human origin recognition complex large subunit is degraded by ubiquitin-mediated proteolysis after initiation of DNA replication. 
  • Human plasmacytoid dendritic cells activated by CpG oligodeoxynucleotides induce the generation of CD4+CD25+ regulatory T cells. 
  • Human syndromes of immunodeficiency and dysregulation are characterized by distinct defects in T-cell receptor repertoire development. 
  • Hydrolytically deficient MutS E694A is defective in the MutL-dependent activation of MutH and in the mismatch-dependent assembly of the MutS.MutL.heteroduplex complex. 
  • Hydrophobic residues Phe751 and Leu753 are essential for STAT5 transcriptional activity. 
  • Hyperlipidemic effects of dietary saturated fats mediated through PGC-1beta coactivation of SREBP. 
  • Hyperphosphorylated C-terminal repeat domain-associating proteins in the nuclear proteome link transcription to DNA/chromatin modification and RNA processing. 
  • IL-7 promotes Glut1 trafficking and glucose uptake via STAT5-mediated activation of Akt to support T-cell survival. 
  • ITF-2, a downstream target of the Wnt/TCF pathway, is activated in human cancers with beta-catenin defects and promotes neoplastic transformation. 
  • Identification and characterization of a highly conserved calcineurin binding protein, CBP1/calcipressin, in Cryptococcus neoformans. 
  • Identification and characterization of an SKN7 homologue in Cryptococcus neoformans. 
  • Identification and characterization of cell type-specific and ubiquitous chromatin regulatory structures in the human genome. 
  • Identification and characterization of upstream open reading frames (uORF) in the 5' untranslated regions (UTR) of genes in Saccharomyces cerevisiae. 
  • Identification of Brassinosteroid Target Genes by Chromatin Immunoprecipitation Followed by High-Throughput Sequencing (ChIP-seq) and RNA-Sequencing. 
  • Identification of E2A target genes in B lymphocyte development by using a gene tagging-based chromatin immunoprecipitation system. 
  • Identification of MeCP2 mutations in a series of females with autistic disorder. 
  • Identification of STRA6 and SKI sequence variants in patients with anophthalmia/microphthalmia. 
  • Identification of a genetic signature of activated signal transducer and activator of transcription 3 in human tumors. 
  • Identification of a melanoma susceptibility locus and somatic mutation in TET2. 
  • Identification of a negative regulatory element involved in tissue-specific expression of mouse renin genes. 
  • Identification of a new subclass of Alu DNA repeats which can function as estrogen receptor-dependent transcriptional enhancers. 
  • Identification of a novel set of genes regulated by a unique liver X receptor-alpha -mediated transcription mechanism. 
  • Identification of calcium-modulating cyclophilin ligand (CAML) as transducer of angiotensin II-mediated nuclear factor of activated T cells (NFAT) activation. 
  • Identification of centromeric antigens in dicentric Robertsonian translocations: CENP-C and CENP-E are necessary components of functional centromeres. 
  • Identification of genetic variants in base excision repair pathway and their associations with risk of esophageal squamous cell carcinoma. 
  • Identification of mZnf8, a mouse Krüppel-like transcriptional repressor, as a novel nuclear interaction partner of Smad1. 
  • Identification of novel hrp-regulated genes through functional genomic analysis of the Pseudomonas syringae pv. tomato DC3000 genome. 
  • Identification of novel mediators of NF-kappaB through genome-wide survey of monocyte adherence-induced genes. 
  • Identification of novel mutations and sequence variants in the SOX2 and CHX10 genes in patients with anophthalmia/microphthalmia. 
  • Identification of novel risk loci for restless legs syndrome in genome-wide association studies in individuals of European ancestry: a meta-analysis. 
  • Identification of risk and age-at-onset genes on chromosome 1p in Parkinson disease. 
  • Identification of transcription factors that regulate ATG8 expression and autophagy in Arabidopsis . 
  • Identifying a novel connection between the fungal plasma membrane and pH-sensing. 
  • Immediate early gene expression in axotomized and regenerating retinal ganglion cells of the adult rat. 
  • Immunogenetic Determinants of Susceptibility to Head and Neck Cancer in the Million Veteran Program Cohort. 
  • Immunohistochemical and genetic analysis of non-small cell and small cell gallbladder carcinoma and their precursor lesions. 
  • Immunological and clinical responses in metastatic renal cancer patients vaccinated with tumor RNA-transfected dendritic cells. 
  • Immunophilins interact with calcineurin in the absence of exogenous immunosuppressive ligands. 
  • Immunosuppressant target protein FKBP12 is required for P-glycoprotein function in yeast. 
  • Immunosurveillance by hematopoietic progenitor cells trafficking through blood, lymph, and peripheral tissues. 
  • Impaired proliferation and tumorigenicity induced by CCAAT/enhancer-binding protein. 
  • Imprinted CDKN1C is a tumor suppressor in rhabdoid tumor and activated by restoration of SMARCB1 and histone deacetylase inhibitors. 
  • Improved datasets and evaluation methods for the automatic prediction of DNA-binding proteins. 
  • Improvements to gene deletion in the fungal pathogen Cryptococcus neoformans: absence of Ku proteins increases homologous recombination, and co-transformation of independent DNA molecules allows rapid complementation of deletion phenotypes. 
  • Improving the clinical risk score: an analysis of molecular biomarkers in the era of modern chemotherapy for resectable hepatic colorectal cancer metastases. 
  • In vitro interleukin-6 treatment prevents mortality associated with fatty liver transplants in rats. 
  • In vitro studies on the bacteriophage P2 terminase system. 
  • In vitro transcriptional studies of the roles of the thyroid hormone (T3) response elements and minimal promoters in T3-stimulated gene transcription. 
  • In vivo footprinting of the human alpha-globin locus upstream regulatory element by guanine and adenine ligation-mediated polymerase chain reaction. 
  • In vivo functional analysis of in vitro protein binding sites in the immunoglobulin heavy chain enhancer. 
  • In vivo interaction between NPR1 and transcription factor TGA2 leads to salicylic acid-mediated gene activation in Arabidopsis. 
  • In vivo regulation of hTERT expression and telomerase activity by androgen. 
  • In vivo requirement for RecJ, ExoVII, ExoI, and ExoX in methyl-directed mismatch repair. 
  • In-vivo studies on the cis-acting replication initiator protein of IncFII plasmid NR1. 
  • Inactivation of the human papillomavirus E6 or E7 gene in cervical carcinoma cells by using a bacterial CRISPR/Cas RNA-guided endonuclease. 
  • Increase in PDX-1 levels suppresses insulin gene expression in RIN 1046-38 cells. 
  • Increased rates of genomic deletions generated by mutations in the yeast gene encoding DNA polymerase delta or by decreases in the cellular levels of DNA polymerase delta. 
  • Independent signals control expression of the calcineurin inhibitory proteins MCIP1 and MCIP2 in striated muscles. 
  • Indistinguishable nuclear factor binding to functional core sites of the T-cell receptor delta and murine leukemia virus enhancers. 
  • Induction of Mesenchymal-Epithelial Transitions in Sarcoma Cells. 
  • Induction of a cellular enzyme for energy metabolism by transforming domains of adenovirus E1a. 
  • Induction of hippocampal long-term potentiation during waking leads to increased extrahippocampal zif-268 expression during ensuing rapid-eye-movement sleep. 
  • Induction of immediate-early genes by angiotensin II and endothelin-1 in adult rat cardiomyocytes. 
  • Induction of lef1 during zebrafish fin regeneration. 
  • Induction of p21waf1 expression and growth inhibition by transforming growth factor beta involve the tumor suppressor gene DPC4 in human pancreatic adenocarcinoma cells. 
  • Induction of stress proteins in cultured myogenic cells. Molecular signals for the activation of heat shock transcription factor during ischemia. 
  • Induction of the protective antioxidant response element pathway by 6-hydroxydopamine in vivo and in vitro. 
  • Inflammation influences vascular remodeling through AT2 receptor expression and signaling. 
  • Influence of ATM function on telomere metabolism. 
  • Inherited causes of clonal haematopoiesis in 97,691 whole genomes. 
  • Inherited genetic susceptibility to acute lymphoblastic leukemia in Down syndrome. 
  • Inhibition of Bmp signaling affects growth and differentiation in the anagen hair follicle. 
  • Inhibition of NF-kappa B by S-nitrosylation. 
  • Inhibition of Pten deficient Castration Resistant Prostate Cancer by Targeting of the SET - PP2A Signaling axis. 
  • Inhibition of cell proliferation by an RNA ligand that selectively blocks E2F function. 
  • Inhibition of the 3-hydroxy-3-methylglutaryl-coenzyme A reductase pathway induces p53-independent transcriptional regulation of p21(WAF1/CIP1) in human prostate carcinoma cells. 
  • Inhibition of the anaphase-promoting complex by the Xnf7 ubiquitin ligase. 
  • Inhibition of transforming growth factor-beta/SMAD signalling by the interferon-gamma/STAT pathway. 
  • Initiating cellular stress responses. 
  • Initiation of methyl-directed mismatch repair. 
  • Inner nuclear envelope proteins SUN1 and SUN2 play a prominent role in the DNA damage response. 
  • Inositol diphosphate signaling regulates telomere length. 
  • Insight into F plasmid DNA segregation revealed by structures of SopB and SopB-DNA complexes. 
  • Insights into the nature of DNA binding of AbrB-like transcription factors. 
  • Integrated genomic characterization of endometrial carcinoma. 
  • Integrated omics networks reveal the temporal signaling events of brassinosteroid response in Arabidopsis. 
  • Integration of cell line and clinical trial genome-wide analyses supports a polygenic architecture of Paclitaxel-induced sensory peripheral neuropathy. 
  • Integration of plasmids into the bacteriophage T4 genome. 
  • Intensive chemotherapy and immunotherapy in patients with newly diagnosed primary CNS lymphoma: CALGB 50202 (Alliance 50202). 
  • Interaction and functional collaboration of p300/CBP and bHLH proteins in muscle and B-cell differentiation. 
  • Interaction between the Ah receptor and proteins binding to the AP-1-like electrophile response element (EpRE) during murine phase II [Ah] battery gene expression. 
  • Interaction between transcriptional activator protein LAC9 and negative regulatory protein GAL80. 
  • Interaction of atrial natriuretic polypeptide and angiotensin II on protooncogene expression and vascular cell growth. 
  • Interaction of the Dr1 inhibitory factor with the TATA binding protein is disrupted by adenovirus E1A. 
  • Interaction of the polyglutamine protein ataxin-3 with Rad23 regulates toxicity in Drosophila models of Spinocerebellar Ataxia Type 3. 
  • Interaction of the regulatory domains of the murine Cyp1a1 gene with two DNA-binding proteins in addition to the Ah receptor and the Ah receptor nuclear translocator (ARNT). 
  • Interactions of TLC1 (which encodes the RNA subunit of telomerase), TEL1, and MEC1 in regulating telomere length in the yeast Saccharomyces cerevisiae. 
  • Interactions of human mismatch repair proteins MutSalpha and MutLalpha with proteins of the ATR-Chk1 pathway. 
  • Interactions of human nucleotide excision repair protein XPA with DNA and RPA70 Delta C327: chemical shift mapping and 15N NMR relaxation studies. 
  • Interconversion of red opsin isoforms by the cyclophilin-related chaperone protein Ran-binding protein 2. 
  • Interferon regulatory factor-1 up-regulates angiotensin II type 2 receptor and induces apoptosis. 
  • Interferon regulatory factors regulate interleukin-1beta-converting enzyme expression and apoptosis in vascular smooth muscle cells. 
  • Interlaboratory validation of a new assay for DNA-protein crosslinks. 
  • Interleukin-3 expression by activated T cells involves an inducible, T-cell-specific factor and an octamer binding protein. 
  • Interleukin-3-induced activation of the JAK/STAT pathway is prolonged by proteasome inhibitors. 
  • Interplay of catalysis, fidelity, threading, and processivity in the exo- and endonucleolytic reactions of human exonuclease I. 
  • Intestinal apolipoprotein AI gene transcription is regulated by multiple distinct DNA elements and is synergistically activated by the orphan nuclear receptor, hepatocyte nuclear factor 4. 
  • Investigation of the PARK10 gene in Parkinson disease. 
  • Investigation of the complexes of EcoRI endonuclease with decanucleotides containing canonical and modified recognition sequences using fluorescence and optical detection of magnetic resonance spectroscopy. 
  • Involvement of the MKK6-p38gamma cascade in gamma-radiation-induced cell cycle arrest. 
  • Involvement of the beta clamp in methyl-directed mismatch repair in vitro. 
  • Involvement of the cohesin protein, Smc1, in Atm-dependent and independent responses to DNA damage. 
  • Ionizing radiation activates the ATM kinase throughout the cell cycle. 
  • Isolation and characterization of cul1-7, a recessive allele of CULLIN1 that disrupts SCF function at the C terminus of CUL1 in Arabidopsis thaliana. 
  • Isolation and characterization of point mutations in mismatch repair genes that destabilize microsatellites in yeast. 
  • Isolation and characterization of the replicon of a Thiobacillus intermedius plasmid. 
  • Isolation and initial characterization of the BRCA2 promoter. 
  • Isolation of MutSbeta from human cells and comparison of the mismatch repair specificities of MutSbeta and MutSalpha. 
  • Isolation of an hMSH2-p160 heterodimer that restores DNA mismatch repair to tumor cells. 
  • Isolation of two E-box binding factors that interact with the rat tyrosine hydroxylase enhancer. 
  • Isolation of unique STAT5 targets by chromatin immunoprecipitation-based gene identification. 
  • Isolation, purification and in vitro differentiation of cytotrophoblast cells from human term placenta. 
  • JAK2 is required for induction of the murine DUB-1 gene. 
  • Janus kinase 3 (JAK3) deficiency: clinical, immunologic, and molecular analyses of 10 patients and outcomes of stem cell transplantation. 
  • KAP-1 promotes resection of broken DNA ends not protected by γ-H2AX and 53BP1 in G₁-phase lymphocytes. 
  • KLF15 is a molecular link between endoplasmic reticulum stress and insulin resistance. 
  • KMT2D maintains neoplastic cell proliferation and global histone H3 lysine 4 monomethylation. 
  • Kindling and associated mossy fibre sprouting are not affected in mice deficient of NGFI-A/NGFI-B genes. 
  • Kinetic role of helix caps in protein folding is context-dependent. 
  • Klf15 orchestrates circadian nitrogen homeostasis. 
  • Kruppel-like factor 15 is required for the cardiac adaptive response to fasting. 
  • LAT is required for TCR-mediated activation of PLCgamma1 and the Ras pathway. 
  • LATE-NC staging in routine neuropathologic diagnosis: an update. 
  • LIN28B polymorphisms influence susceptibility to epithelial ovarian cancer. 
  • LUX ARRHYTHMO encodes a novel Myb-like transcription factor essential for circadian rhythms 
  • LXRalpha functions as a cAMP-responsive transcriptional regulator of gene expression. 
  • Learning protein-DNA interaction landscapes by integrating experimental data through computational models. 
  • Lefty inhibits receptor-regulated Smad phosphorylation induced by the activated transforming growth factor-beta receptor. 
  • Lineage-specific signaling in melanocytes. C-kit stimulation recruits p300/CBP to microphthalmia. 
  • Lipopolysaccharide stimulates mitochondrial biogenesis via activation of nuclear respiratory factor-1. 
  • Liver X receptors alpha and beta regulate renin expression in vivo. 
  • Local nucleosome dynamics and eviction following a double-strand break are reversible by NHEJ-mediated repair in the absence of DNA replication. 
  • Long-term stabilization of vein graft wall architecture and prolonged resistance to experimental atherosclerosis after E2F decoy oligonucleotide gene therapy. 
  • Loss of ARID1A in Tumor Cells Renders Selective Vulnerability to Combined Ionizing Radiation and PARP Inhibitor Therapy. 
  • Loss of ARID1A-associated protein expression is a frequent event in clear cell and endometrioid ovarian cancers. 
  • Loss of Smad3-mediated negative regulation of Runx2 activity leads to an alteration in cell fate determination. 
  • Loss of atm radiosensitizes multiple p53 null tissues. 
  • Loss of the mismatch repair protein MSH6 in human glioblastomas is associated with tumor progression during temozolomide treatment. 
  • Low levels of DNA polymerase alpha induce mitotic and meiotic instability in the ribosomal DNA gene cluster of Saccharomyces cerevisiae. 
  • LvGroucho and nuclear beta-catenin functionally compete for Tcf binding to influence activation of the endomesoderm gene regulatory network in the sea urchin embryo. 
  • Lymphocyte development and function in the absence of retinoic acid-related orphan receptor alpha. 
  • Lymphomatosis Cerebri: A Diagnostic Challenge. 
  • MAP kinase phosphorylation-dependent activation of Elk-1 leads to activation of the co-activator p300. 
  • MAP kinase signaling specificity mediated by the LIN-1 Ets/LIN-31 WH transcription factor complex during C. elegans vulval induction. 
  • MEF2 responds to multiple calcium-regulated signals in the control of skeletal muscle fiber type. 
  • MRE11-deficiency associated with improved long-term disease free survival and overall survival in a subset of stage III colon cancer patients in randomized CALGB 89803 trial. 
  • MSH6 inactivation and emergent temozolomide resistance in human glioblastomas. 
  • MSH6, a Saccharomyces cerevisiae protein that binds to mismatches as a heterodimer with MSH2. 
  • Macromolecular assembly of the transition state regulator AbrB in its unbound and complexed states probed by microelectrospray ionization mass spectrometry. 
  • Male-specific cell migration into the developing gonad. 
  • Mammalian dwarfins are phosphorylated in response to transforming growth factor beta and are implicated in control of cell growth. 
  • Mammalian homologs of Drosophila ELAV localized to a neuronal subset can bind in vitro to the 3' UTR of mRNA encoding the Id transcriptional repressor. 
  • Management of high, moderate, and low penetrance ovarian cancer susceptibility mutations: an assessment of current risk reduction practices. 
  • Maternal Diet and Insulin-Like Signaling Control Intergenerational Plasticity of Progeny Size and Starvation Resistance. 
  • Mcm10 and And-1/CTF4 recruit DNA polymerase alpha to chromatin for initiation of DNA replication. 
  • Mcm2-7 Is an Active Player in the DNA Replication Checkpoint Signaling Cascade via Proposed Modulation of Its DNA Gate. 
  • Mechanism of 5'-directed excision in human mismatch repair. 
  • Mechanism of apoptosis and determination of cellular fate in chromium(VI)-exposed populations of telomerase-immortalized human fibroblasts. 
  • Mechanism of corepressor-mediated specific DNA binding by the purine repressor. 
  • Mechanisms of DNA-mismatch correction. 
  • Meiotic recombination involving heterozygous large insertions in Saccharomyces cerevisiae: formation and repair of large, unpaired DNA loops. 
  • Melanoma Expression Genes Identified through Genome-Wide Association Study of Breslow Tumor Thickness. 
  • Mesenchymal-Epithelial Transition in Sarcomas Is Controlled by the Combinatorial Expression of MicroRNA 200s and GRHL2. 
  • Mesonephric cell migration induces testis cord formation and Sertoli cell differentiation in the mammalian gonad. 
  • MetJ repressor interactions with DNA probed by in-cell NMR. 
  • Methionine oxidation of monomeric lambda repressor: the denatured state ensemble under nondenaturing conditions. 
  • Methyl-CpG binding domain 1 gene polymorphisms and lung cancer risk in a Chinese population. 
  • Methyl-directed DNA mismatch repair in Escherichia coli. 
  • Methyl-directed mismatch repair is bidirectional. 
  • Microchimerism in sensitized renal patients. 
  • Microcytic anemia in mk/mk mice is not corrected by retroviral-mediated gene transfer of wild-type p45 NF-E2. 
  • Microglia: a promising target for treating neuropathic and postoperative pain, and morphine tolerance. 
  • Microphthalmia-associated transcription factor (MITF) locus lacks linkage to human vitiligo or osteopetrosis: an evaluation. 
  • Microsatellite instability in gynecological sarcomas and in hMSH2 mutant uterine sarcoma cell lines defective in mismatch repair activity. 
  • Microsecond protein folding through a compact transition state. 
  • Migration of mesonephric cells into the mammalian gonad depends on Sry. 
  • Mimetics of caloric restriction include agonists of lipid-activated nuclear receptors. 
  • Minimal phenotype of mice homozygous for a null mutation in the forkhead/winged helix gene, Mf2. 
  • Mismatch recognition and subsequent processing have distinct effects on mitotic recombination intermediates and outcomes in yeast. 
  • Mismatch repair and nucleotide excision repair proteins cooperate in the recognition of DNA interstrand crosslinks. 
  • Mismatch repair proteins MutS and MutL inhibit RecA-catalyzed strand transfer between diverged DNAs. 
  • Mismatch repair proteins and mitotic genome stability. 
  • Mismatch-, MutS-, MutL-, and helicase II-dependent unwinding from the single-strand break of an incised heteroduplex. 
  • Mismatch-containing oligonucleotide duplexes bound by the E. coli mutS-encoded protein. 
  • Missense variants in the chromatin remodeler CHD1 are associated with neurodevelopmental disability. 
  • Mitochondrial dysfunction in ataxia-telangiectasia. 
  • Mitochondrial hTERT exacerbates free-radical-mediated mtDNA damage. 
  • Mitogen-activated protein kinases enhance long-range activation by the beta-globin locus control region. 
  • Mitogens stimulate the rapid nuclear to cytosolic translocation of tristetraprolin, a potential zinc-finger transcription factor. 
  • Modulation of MutS ATP hydrolysis by DNA cofactors. 
  • Modulation of human nuclear receptor LRH-1 activity by phospholipids and SHP. 
  • Modulation of nucleotide excision repair capacity by XPD polymorphisms in lung cancer patients. 
  • Modulatory function of CREB.CREM alpha heterodimers depends upon CREM alpha phosphorylation. 
  • Molecular analysis of the JAZF1-JJAZ1 gene fusion by RT-PCR and fluorescence in situ hybridization in endometrial stromal neoplasms. 
  • Molecular and clinical analyses of Greig cephalopolysyndactyly and Pallister-Hall syndromes: robust phenotype prediction from the type and position of GLI3 mutations. 
  • Molecular characterization and localization of the human MAFG gene. 
  • Molecular evolutionary and structural analysis of the cytosolic DNA sensor cGAS and STING. 
  • Molecular mapping of brain areas involved in parrot vocal communication. 
  • Molecular mechanism of tissue-specific regulation of mouse renin gene expression by cAMP. Identification of an inhibitory protein that binds nuclear transcriptional factor. 
  • Molecular mechanisms of HipA-mediated multidrug tolerance and its neutralization by HipB. 
  • Molecular mechanisms of dominant negative activity by nuclear hormone receptors. 
  • Molecular mechanisms of immunosuppression by cyclosporine, FK506, and rapamycin. 
  • Molecular signatures of thyroid follicular neoplasia. 
  • Mouse Mesenchyme forkhead 2 (Mf2): expression, DNA binding and induction by sonic hedgehog during somitogenesis. 
  • Mouse embryonic stem cells carrying one or two defective Msh2 alleles respond abnormally to oxidative stress inflicted by low-level radiation. 
  • Mouse microcytic anaemia caused by a defect in the gene encoding the globin enhancer-binding protein NF-E2. 
  • Msx1 and Pax3 cooperate to mediate FGF8 and WNT signals during Xenopus neural crest induction. 
  • Multicenter study of acetaminophen hepatotoxicity reveals the importance of biological endpoints in genomic analyses. 
  • Multifocal anaplastic astrocytoma in a patient with hereditary colorectal cancer, transcobalamin II deficiency, agenesis of the corpus callosum, mental retardation, and inherited PMS2 mutation. 
  • Multiple DNA repair mechanisms and alkylator resistance in the human medulloblastoma cell line D-283 Med (4-HCR). 
  • Multiple different missense mutations in the pore region of HERG in patients with long QT syndrome. 
  • Multiple domains of MCIP1 contribute to inhibition of calcineurin activity. 
  • Multiple dose-dependent roles for Sox2 in the patterning and differentiation of anterior foregut endoderm. 
  • Multiple signaling pathways involving ATM. 
  • Multiple, conserved cryptic recombination signals in VH gene segments: detection of cleavage products only in pro B cells. 
  • Multiplex CRISPR/Cas9-based genome engineering from a single lentiviral vector. 
  • Multivariate proteomic analysis of murine embryonic stem cell self-renewal versus differentiation signaling. 
  • Murine forkhead/winged helix genes Foxc1 (Mf1) and Foxc2 (Mfh1) are required for the early organogenesis of the kidney and urinary tract. 
  • Murine monoclonal antibodies specific for conserved and non-conserved antigenic determinants of the human and murine Ku autoantigens. 
  • MutS and MutL activate DNA helicase II in a mismatch-dependent manner. 
  • MutS mediates heteroduplex loop formation by a translocation mechanism. 
  • Mutagenic analysis of functional domains of the mos proto-oncogene and identification of the sites important for MAPK activation and DNA binding. 
  • Mutation detection with MutH, MutL, and MutS mismatch repair proteins. 
  • Mutation in the mismatch repair gene Msh6 causes cancer susceptibility. 
  • Mutational analysis defines a minimum level of telomerase activity required for tumourigenic growth of human cells. 
  • Mutations in CIC and FUBP1 contribute to human oligodendroglioma. 
  • Mutations in NCAPG2 Cause a Severe Neurodevelopmental Syndrome that Expands the Phenotypic Spectrum of Condensinopathies. 
  • Mutations in TFAM, encoding mitochondrial transcription factor A, cause neonatal liver failure associated with mtDNA depletion. 
  • Mutations in the MSH3 gene preferentially lead to deletions within tracts of simple repetitive DNA in Saccharomyces cerevisiae. 
  • Mutations of the forkhead/winged-helix gene, FKHL7, in patients with Axenfeld-Rieger anomaly. 
  • Myc requires distinct E2F activities to induce S phase and apoptosis. 
  • Myocyte nuclear factor, a novel winged-helix transcription factor under both developmental and neural regulation in striated myocytes. 
  • Myocyte-enriched calcineurin-interacting protein, MCIP1, inhibits cardiac hypertrophy in vivo. 
  • Myogenic stem cell function is impaired in mice lacking the forkhead/winged helix protein MNF. 
  • Myristoylation of calcineurin B is not required for function or interaction with immunophilin-immunosuppressant complexes in the yeast Saccharomyces cerevisiae. 
  • N-(2-Benzoylphenyl)-L-tyrosine PPARgamma agonists. 1. Discovery of a novel series of potent antihyperglycemic and antihyperlipidemic agents. 
  • N-methyl-D-aspartate receptors activate transcription of c-fos and NGFI-A by distinct phospholipase A2-requiring intracellular signaling pathways. 
  • NF-kappaB RelA opposes epidermal proliferation driven by TNFR1 and JNK. 
  • NF-kappaB and AP-1 connection: mechanism of NF-kappaB-dependent regulation of AP-1 activity. 
  • NF-kappaB cis-acting motifs of the human immunodeficiency virus (HIV) long terminal repeat regulate HIV transcription in human macrophages. 
  • NMR assignment of the SRI domain of human Set2/HYPB. 
  • NMR solution structure and DNA-binding model of the DNA-binding domain of competence protein A. 
  • NMR structure of AbhN and comparison with AbrBN: FIRST insights into the DNA binding promiscuity and specificity of AbrB-like transition state regulator proteins. 
  • NPR1 modulates cross-talk between salicylate- and jasmonate-dependent defense pathways through a novel function in the cytosol. 
  • Narp and NP1 form heterocomplexes that function in developmental and activity-dependent synaptic plasticity. 
  • Nascent chromatin occupancy profiling reveals locus- and factor-specific chromatin maturation dynamics behind the DNA replication fork. 
  • Nef stimulates proliferation of glomerular podocytes through activation of Src-dependent Stat3 and MAPK1,2 pathways. 
  • Negative regulation of DNA replication by the retinoblastoma protein is mediated by its association with MCM7. 
  • Neisseria gonorrhoeae FitA interacts with FitB to bind DNA through its ribbon-helix-helix motif. 
  • Neoteny in lymphocytes: Rag1 and Rag2 expression in germinal center B cells. 
  • Nerve activity-dependent modulation of calcineurin signaling in adult fast and slow skeletal muscle fibers. 
  • Neurabins recruit protein phosphatase-1 and inhibitor-2 to the actin cytoskeleton. 
  • Neural cell adhesion molecule (CD56)-positive acute myelogenous leukemia and myelodysplastic and myeloproliferative syndromes. 
  • Neural induction and patterning in the mouse in the absence of the node and its derivatives. 
  • Neuronal regulation of the spatial patterning of neurogenesis. 
  • Neuropathological associations of limbic-predominant age-related TDP-43 encephalopathy neuropathological change (LATE-NC) differ between the oldest-old and younger-old. 
  • Neurotoxic microglia promote TDP-43 proteinopathy in progranulin deficiency. 
  • Neurotrophins and netrins require calcineurin/NFAT signaling to stimulate outgrowth of embryonic axons. 
  • New bedfellows in the mammalian sex-determination affair. 
  • New insights into E-protein function in lymphocyte development. 
  • Newborns of obese parents have altered DNA methylation patterns at imprinted genes. 
  • Ninety-six haploid yeast strains with individual disruptions of open reading frames between YOR097C and YOR192C, constructed for the Saccharomyces genome deletion project, have an additional mutation in the mismatch repair gene MSH3. 
  • Nitric oxide synthase-2 regulates mitochondrial Hsp60 chaperone function during bacterial peritonitis in mice. 
  • Nkx6.1 regulates islet β-cell proliferation via Nr4a1 and Nr4a3 nuclear receptors. 
  • No evidence of an association of ERCC1 and ERCC2 polymorphisms with clinical outcomes of platinum-based chemotherapies in non-small cell lung cancer: a meta-analysis. 
  • Nomenclature: vertebrate mediators of TGFbeta family signals. 
  • Nonconsensus Protein Binding to Repetitive DNA Sequence Elements Significantly Affects Eukaryotic Genomes. 
  • Notch promotes survival of pre-T cells at the beta-selection checkpoint by regulating cellular metabolism. 
  • Notch signaling genes: myogenic DNA hypomethylation and 5-hydroxymethylcytosine. 
  • Novel Genetic Loci Associated With Retinal Microvascular Diameter. 
  • Novel Sfp1 transcriptional regulation of Saccharomyces cerevisiae gene expression changes during spaceflight. 
  • Novel compound heterozygous variants in CECR1 gene associated with childhood onset polyarteritis nodosa and deficiency of ADA2. 
  • Novel missense mutation in the cyclic nucleotide-binding domain of HERG causes long QT syndrome. 
  • Novel nuclear target for thrombin: activation of the Elk1 transcription factor leads to chemokine gene expression. 
  • Novel regulation of cardiac force-frequency relation by CREM (cAMP response element modulator). 
  • Novel susceptibility variants at 10p12.31-12.2 for childhood acute lymphoblastic leukemia in ethnically diverse populations. 
  • Nuclear factor kappa B mediates lipopolysaccharide-induced inflammation in the urinary bladder. 
  • Nuclear oncoprotein expression as a function of lineage, differentiation stage, and proliferative status of normal human hematopoietic cells. 
  • Nuclear receptor LXRalpha is involved in cAMP-mediated human renin gene expression. 
  • Nucleolin mediates nucleosome disruption critical for DNA double-strand break repair. 
  • Nucleotide excision repair functions in the removal of chromium-induced DNA damage in mammalian cells. 
  • Nucleotide-promoted release of hMutSalpha from heteroduplex DNA is consistent with an ATP-dependent translocation mechanism. 
  • Obligatory role for cooperative signaling by pre-TCR and Notch during thymocyte differentiation. 
  • Observation of incipient tumor angiogenesis that is independent of hypoxia and hypoxia inducible factor-1 activation. 
  • Oct4 RNA interference induces trophectoderm differentiation in mouse embryonic stem cells. 
  • Oncogenic activation of c-ABL by mutation within its last exon. 
  • Optimal sequence selection in proteins of known structure by simulated evolution. 
  • Optimizing aptamer activity for gene therapy applications using expression cassette SELEX. 
  • Oral glutamine enhances heat shock protein expression and improves survival following hyperthermia. 
  • Organizing mRNA export. 
  • Orphan nuclear receptors in T lymphocyte development. 
  • Our cells get stressed too! Implications for human disease. 
  • Overexpression of SKI oncoprotein leads to p53 degradation through regulation of MDM2 protein sumoylation. 
  • Overexpression of leptin receptors in pancreatic islets of Zucker diabetic fatty rats restores GLUT-2, glucokinase, and glucose-stimulated insulin secretion. 
  • Overexpression of the ETS-related gene, ERG, predicts a worse outcome in acute myeloid leukemia with normal karyotype: a Cancer and Leukemia Group B study. 
  • Overexpression of tropomysin-related kinase B in metastatic human pancreatic cancer cells. 
  • Overlapping specificities of base excision repair, nucleotide excision repair, recombination, and translesion synthesis pathways for DNA base damage in Saccharomyces cerevisiae. 
  • PAS is a dimerization domain common to Drosophila period and several transcription factors. 
  • PD-linked CHCHD2 mutations impair CHCHD10 and MICOS complex leading to mitochondria dysfunction. 
  • PGC-1alpha mRNA expression is influenced by metabolic perturbation in exercising human skeletal muscle. 
  • PGC-1α senses the CBC of pre-mRNA to dictate the fate of promoter-proximally paused RNAPII. 
  • PKA, PKC, and the protein phosphatase 2A influence HAND factor function: a mechanism for tissue-specific transcriptional regulation. 
  • PLANT NATRIURETIC PEPTIDE A and Its Putative Receptor PNP-R2 Antagonize Salicylic Acid-Mediated Signaling and Cell Death. 
  • PLP/DM20 ratio is regulated by hnRNPH and F and a novel G-rich enhancer in oligodendrocytes. 
  • PMS2 endonuclease activity has distinct biological functions and is essential for genome maintenance. 
  • PPDPF alleviates hepatic steatosis through inhibition of mTOR signaling. 
  • PURA Syndrome and Myotonia. 
  • Paracrine signaling through the JAK/STAT pathway activates invasive behavior of ovarian epithelial cells in Drosophila. 
  • Partial RAG deficiency in humans induces dysregulated peripheral lymphocyte development and humoral tolerance defect with accumulation of T-bet+ B cells. 
  • Participation of ATM in insulin signalling through phosphorylation of eIF-4E-binding protein 1. 
  • Participation of c-FLIP in NLRP3 and AIM2 inflammasome activation. 
  • Patterns of nucleotide variation and reproductive isolation between a Mimulus allotetraploid and its progenitor species. 
  • Patterns of regulatory activity across diverse human cell types predict tissue identity, transcription factor binding, and long-range interactions. 
  • Pdgfrβ+ Mural Preadipocytes Contribute to Adipocyte Hyperplasia Induced by High-Fat-Diet Feeding and Prolonged Cold Exposure in Adult Mice. 
  • Peripheral subnuclear positioning suppresses Tcrb recombination and segregates Tcrb alleles from RAG2. 
  • Perivascular mesenchymal cells control adipose-tissue macrophage accrual in obesity. 
  • Peroxide-mediated chromatin remodelling of a nuclear factor kappa B site in the mouse inducible nitric oxide synthase promoter. 
  • Peroxisome proliferator-activated receptor-alpha regulates fatty acid utilization in primary human skeletal muscle cells. 
  • Persistent expression of MNF identifies myogenic stem cells in postnatal muscles. 
  • Phage display screening for peptides that inhibit polyglutamine aggregation. 
  • Phenotypic abnormalities in macrophages from leptin-deficient, obese mice. 
  • Phenotypic expansion of Bosch-Boonstra-Schaaf optic atrophy syndrome and further evidence for genotype-phenotype correlations. 
  • Phenotypic expansion of KMT2D-related disorder: Beyond Kabuki syndrome. 
  • Phosphoprotein Crh-Ser46-P displays altered binding to CcpA to effect carbon catabolite regulation. 
  • Phosphorylation by protein kinase CK2 changes the DNA binding properties of the human chromatin protein DEK. 
  • Phosphorylation of SMC1 is a critical downstream event in the ATM-NBS1-BRCA1 pathway. 
  • Phosphorylation of serine 1387 in Brca1 is specifically required for the Atm-mediated S-phase checkpoint after ionizing irradiation. 
  • Phosphorylation of the group A Streptococcal CovR response regulator causes dimerization and promoter-specific recruitment by RNA polymerase. 
  • Phosphorylation of the rRNA transcription factor upstream binding factor promotes its association with TATA binding protein. 
  • Phosphorylation of tristetraprolin, a potential zinc finger transcription factor, by mitogen stimulation in intact cells and by mitogen-activated protein kinase in vitro. 
  • Phycomyces MADB interacts with MADA to form the primary photoreceptor complex for fungal phototropism. 
  • Physical interaction between VIVID and white collar complex regulates photoadaptation in Neurospora. 
  • Plant hormone jasmonate prioritizes defense over growth by interfering with gibberellin signaling cascade 
  • Plant transcription factors - being in the right place with the right company. 
  • Plasmacellular differentiation in extranodal marginal zone B cell lymphomas of the ocular adnexa: an analysis of the neoplastic plasma cell phenotype and its prognostic significance in 136 cases. 
  • Plasmid models for bacteriophage T4 DNA replication: requirements for fork proteins. 
  • Plasmid protein TubR uses a distinct mode of HTH-DNA binding and recruits the prokaryotic tubulin homolog TubZ to effect DNA partition. 
  • Pleiotropic effects of HIF-1 blockade on tumor radiosensitivity. 
  • Polymorphisms in DNA base excision repair genes ADPRT and XRCC1 and risk of lung cancer. 
  • Polymorphisms in DNA damage binding protein 2 (DDB2) and susceptibility of primary lung cancer in the Chinese: a case-control study. 
  • Polymorphisms in ERCC1 and XPF genes and risk of gastric cancer in an eastern Chinese population. 
  • Polymorphisms in NF-kappaB inhibitors and risk of epithelial ovarian cancer. 
  • Polymorphisms in excision repair cross-complementing group 4 (ERCC4) and susceptibility to primary lung cancer in a Chinese Han population. 
  • Polymorphisms in the DNA repair genes XPC, XPD, and XPG and risk of cutaneous melanoma: a case-control analysis. 
  • Polymorphisms in the ERCC5 gene and risk of esophageal squamous cell carcinoma (ESCC) in Eastern Chinese populations. 
  • Polymorphisms in the XPG gene and risk of gastric cancer in Chinese populations. 
  • Polymorphisms in the two helicases ERCC2/XPD and ERCC3/XPB of the transcription factor IIH complex and risk of lung cancer: a case-control analysis in a Chinese population. 
  • Polymorphisms of DNA repair gene XRCC1 in squamous cell carcinoma of the head and neck. 
  • Polymorphisms of DNA repair gene XRCC3 Thr241Met and risk of gastric cancer in a Chinese population. 
  • Polymorphisms of DNA repair genes and risk of glioma. 
  • Polymorphisms of LIG4 and XRCC4 involved in the NHEJ pathway interact to modify risk of glioma. 
  • Polymorphisms of TP53 Arg72Pro, but not p73 G4C14>A4TA4 and p21 Ser31Arg, contribute to risk of cutaneous melanoma. 
  • Polymorphisms of XPG/ERCC5 and risk of squamous cell carcinoma of the head and neck. 
  • Polymorphisms of homologous recombination genes and clinical outcomes of non-small cell lung cancer patients treated with definitive radiotherapy. 
  • Polymorphisms of nucleotide excision repair genes predict melanoma survival. 
  • Polymorphisms of p16, p27, p73, and MDM2 modulate response and survival of pancreatic cancer patients treated with preoperative chemoradiation. 
  • Polymorphisms of the DNA repair gene XPD and risk of lung cancer in a Chinese population. 
  • Polymorphisms of the DNA repair gene XRCC1 and risk of gastric cancer in a Chinese population. 
  • Positive selection on a human-specific transcription factor binding site regulating IL4 expression. 
  • Postlipopolysaccharide oxidative damage of mitochondrial DNA. 
  • Potentially functional single nucleotide polymorphisms in the core nucleotide excision repair genes and risk of squamous cell carcinoma of the head and neck. 
  • Potentially functional variants in the core nucleotide excision repair genes predict survival in Japanese gastric cancer patients. 
  • Pre-established Chromatin Interactions Mediate the Genomic Response to Glucocorticoids. 
  • Precise arrangement of factor-binding sites is required for murine CD4 promoter function. 
  • Preliminary structural studies on the multi-ligand-binding domain of the transcription activator, BmrR, from Bacillus subtilis. 
  • Prevalence of transcription promoters within archaeal operons and coding sequences. 
  • Probing conformational changes in human DNA topoisomerase IIα by pulsed alkylation mass spectrometry. 
  • Probing the DNA sequence specificity of Escherichia coli RECA protein. 
  • Prognostic impact of c-Rel nuclear expression and REL amplification and crosstalk between c-Rel and the p53 pathway in diffuse large B-cell lymphoma. 
  • Prognostic methylation markers for overall survival in cytogenetically normal patients with acute myeloid leukemia treated on SWOG trials. 
  • Prognostic significance of mucin and p53 expression in stage IB non-small cell lung cancer: a laboratory companion study to CALGB 9633. 
  • Prokaryotic transcription regulators: more than just the helix-turn-helix motif. 
  • Prolactin induction of insulin gene transcription: roles of glucose and signal transducer and activator of transcription 5. 
  • Prominent Dutcher body formation in a case of follicular lymphoma with BCL6 gene rearrangement and intact BCL2 gene. 
  • Promoter analysis of Zfp-36, the mitogen-inducible gene encoding the zinc finger protein tristetraprolin. 
  • Promoter methylation and silencing of the tissue factor pathway inhibitor-2 (TFPI-2), a gene encoding an inhibitor of matrix metalloproteinases in human glioma cells. 
  • Promotion of the development of enteric neurons and glia by neuropoietic cytokines: interactions with neurotrophin-3. 
  • Prostate-derived Ets factor, an oncogenic driver in breast cancer. 
  • Prostate-specific expression of p53(R172L) differentially regulates p21, Bax, and mdm2 to inhibit prostate cancer progression and prolong survival. 
  • Protection from mitochondrial complex II inhibition in vitro and in vivo by Nrf2-mediated transcription. 
  • Protective responses in the ischemic myocardium. 
  • Protein folding dynamics: quantitative comparison between theory and experiment. 
  • Protein interactions among the vaccinia virus late transcription factors. 
  • Protein kinase activity of Tel1p and Mec1p, two Saccharomyces cerevisiae proteins related to the human ATM protein kinase. 
  • Protein phosphatase 1 regulation by inhibitors and targeting subunits. 
  • Protein-DNA binding in the absence of specific base-pair recognition. 
  • Protein-DNA binding: complexities and multi-protein codes. 
  • Protein-DNA conformational changes in the crystal structure of a lambda Cro-operator complex. 
  • Protein-protein and protein-DNA interactions at the bacteriophage T4 DNA replication fork. Characterization of a fluorescently labeled DNA polymerase sliding clamp. 
  • Proteolysis of Rad17 by Cdh1/APC regulates checkpoint termination and recovery from genotoxic stress. 
  • Proteome-wide analysis reveals widespread lysine acetylation of major protein complexes in the malaria parasite. 
  • Pseudomonas syringae pv. tomato DC3000 HopPtoM (CEL ORF3) is important for lesion formation but not growth in tomato and is secreted and translocated by the Hrp type III secretion system in a chaperone-dependent manner. 
  • Purification of the human NF-E2 complex: cDNA cloning of the hematopoietic cell-specific subunit and evidence for an associated partner. 
  • Purified MotA protein binds the -30 region of a bacteriophage T4 middle-mode promoter and activates transcription in vitro. 
  • Putative telomere-recruiting domain in the catalytic subunit of human telomerase. 
  • Quorum-sensing regulation of a copper toxicity system in Pseudomonas aeruginosa. 
  • R-spondin1 tips the balance in sex determination. 
  • RAG2:GFP knockin mice reveal novel aspects of RAG2 expression in primary and peripheral lymphoid tissues. 
  • RB regulates transcription of the p21/WAF1/CIP1 gene. 
  • RCC1, a regulator of mitosis, is essential for DNA replication. 
  • RD26 mediates crosstalk between drought and brassinosteroid signalling pathways. 
  • REST and stress resistance in ageing and Alzheimer's disease. 
  • REV3L 3'UTR 460 T>C polymorphism in microRNA target sites contributes to lung cancer susceptibility. 
  • RNA interference of human papillomavirus type 18 E6 and E7 induces senescence in HeLa cells. 
  • RU486 exerts antiestrogenic activities through a novel progesterone receptor A form-mediated mechanism. 
  • RUNX3 inhibits cell proliferation and induces apoptosis by reinstating transforming growth factor beta responsiveness in esophageal adenocarcinoma cells. 
  • Rad17 recruits the MRE11-RAD50-NBS1 complex to regulate the cellular response to DNA double-strand breaks. 
  • Rad18 confers hematopoietic progenitor cell DNA damage tolerance independently of the Fanconi Anemia pathway in vivo. 
  • Radiation activates HIF-1 to regulate vascular radiosensitivity in tumors: role of reoxygenation, free radicals, and stress granules. 
  • Radiation response genotype and risk of differentiated thyroid cancer: a case-control analysis. 
  • Rapamycin and p53 act on different pathways to induce G1 arrest in mammalian cells. 
  • Rapid Akt activation by nicotine and a tobacco carcinogen modulates the phenotype of normal human airway epithelial cells. 
  • Rapid detection of SMARCB1 sequence variation using high resolution melting. 
  • Rare and de novo coding variants in chromodomain genes in Chiari I malformation. 
  • RasGRP1 is a potential biomarker to stratify anti-EGFR therapy response in colorectal cancer. 
  • Rasagiline for amyotrophic lateral sclerosis: A randomized, controlled trial. 
  • Rationale and design of Total Therapy Study XV for newly diagnosed childhood acute lymphoblastic leukemia. 
  • Reaction mechanism of human DNA repair excision nuclease. 
  • Real-time imaging of morphogenetic movements in Drosophila using Gal4-UAS-driven expression of GFP fused to the actin-binding domain of moesin. 
  • Receptors that induce erythroid differentiation of Ba/F3 cells: structural requirements and effect on STAT5 binding. 
  • Recognition and repair of compound DNA lesions (base damage and mismatch) by human mismatch repair and excision repair systems. 
  • Recombination between homologous chromosomes induced by unrepaired UV-generated DNA damage requires Mus81p and is suppressed by Mms2p. 
  • Recruiting substrates to cullin 4-dependent ubiquitin ligases by DDB1. 
  • Redox-mediated upregulation of hepatocyte iNOS transcription requires coactivator PC4. 
  • Reduced DNA repair of benzo[a]pyrene diol epoxide-induced adducts and common XPD polymorphisms in breast cancer patients. 
  • Reduced expression levels of nucleotide excision repair genes in lung cancer: a case-control analysis. 
  • Reduced expression of hMLH1 and hGTBP/hMSH6: a risk factor for head and neck cancer. 
  • Reduced expression of hMSH2 and hMLH1 and risk of prostate cancer: a case-control study. 
  • Reduced expression of mismatch repair genes in colorectal cancer patients in Egypt. 
  • Reduced expression of mismatch repair genes measured by multiplex reverse transcription-polymerase chain reaction in human gliomas. 
  • Reduced mRNA expression of nucleotide excision repair genes in lymphocytes and risk of squamous cell carcinoma of the head and neck. 
  • Refinement of the PARK3 locus on chromosome 2p13 and the analysis of 14 candidate genes. 
  • Regeneration of fat cells from myofibroblasts during wound healing. 
  • Regenerative changes in C/EBP alpha and C/EBP beta expression modulate binding to the C/EBP site in the c-fos promoter. 
  • Regulation of ALK-1 signaling by the nuclear receptor LXRbeta. 
  • Regulation of E2A activities by histone acetyltransferases in B lymphocyte development. 
  • Regulation of NFkappaB in hepatic ischemic preconditioning. 
  • Regulation of T cell receptor delta gene rearrangement by CBF/PEBP2. 
  • Regulation of T cell receptor delta gene rearrangement by c-Myb. 
  • Regulation of TCRβ allelic exclusion by gene segment proximity and accessibility. 
  • Regulation of V(D)J recombination: a dominant role for promoter positioning in gene segment accessibility. 
  • Regulation of a cyclin-CDK-CDK inhibitor complex by inositol pyrophosphates. 
  • Regulation of chromatin accessibility for V(D)J recombination. 
  • Regulation of early adipose commitment by Zfp521. 
  • Regulation of early lymphocyte development by E2A family proteins. 
  • Regulation of group VIA phospholipase A2 expression by sterol availability. 
  • Regulation of male germ cell cycle arrest and differentiation by DND1 is modulated by genetic background. 
  • Regulation of systemic acquired resistance by NPR1 and its partners. 
  • Regulation of the T-cell receptor delta enhancer by functional cooperation between c-Myb and core-binding factors. 
  • Regulation of the germinal center gene program by interferon (IFN) regulatory factor 8/IFN consensus sequence-binding protein. 
  • Regulation of the murine Ddelta2 promoter by upstream stimulatory factor 1, Runx1, and c-Myb. 
  • Regulation of the transcriptional activator NtrC1: structural studies of the regulatory and AAA+ ATPase domains. 
  • Regulation of the uncoupling protein-2 gene in INS-1 beta-cells by oleic acid. 
  • Reinterpretation of GCN4-p1 folding kinetics: partial helix formation precedes dimerization in coiled coil folding. 
  • RelB modulation of IkappaBalpha stability as a mechanism of transcription suppression of interleukin-1alpha (IL-1alpha), IL-1beta, and tumor necrosis factor alpha in fibroblasts. 
  • Relationship between expression of coactivators and corepressors of hormone receptors and resistance of ovarian cancers to growth regulation by steroid hormones. 
  • Relevance and safety of telomerase for human tissue engineering. 
  • Remodeling muscles with calcineurin. 
  • Removal of frameshift intermediates by mismatch repair proteins in Saccharomyces cerevisiae. 
  • Renaming the DSCR1/Adapt78 gene family as RCAN: regulators of calcineurin. 
  • Repair of DNA loops involves DNA-mismatch and nucleotide-excision repair proteins. 
  • Repair versus Checkpoint Functions of BRCA1 Are Differentially Regulated by Site of Chromatin Binding. 
  • Replication factors MCM2 and ORC1 interact with the histone acetyltransferase HBO1. 
  • Repression of the human papillomavirus E6 gene initiates p53-dependent, telomerase-independent senescence and apoptosis in HeLa cervical carcinoma cells. 
  • Repurposing Pan-HDAC Inhibitors for ARID1A-Mutated Ovarian Cancer. 
  • Requirement for JAK/STAT signaling throughout border cell migration in Drosophila. 
  • Requirement of estrogen receptor alpha DNA-binding domain for HPV oncogene-induced cervical carcinogenesis in mice. 
  • Requirement of protein phosphatase 5 in DNA-damage-induced ATM activation. 
  • Requirement of the Src homology 2 domain protein Shb for T cell receptor-dependent activation of the interleukin-2 gene nuclear factor for activation of T cells element in Jurkat T cells. 
  • Rescue of an hTERT mutant defective in telomere elongation by fusion with hPot1. 
  • Resistance to thyroid hormone in a patient without thyroid hormone receptor mutations. 
  • Restricted expression of WT1 messenger ribonucleic acid in immature ovarian follicles: uniformity in mammalian and avian species and maintenance during reproductive senescence. 
  • Resveratrol and endometrium: a closer look at an active ingredient of red wine using in vivo and in vitro models. 
  • Retinal ganglion cell genesis requires lakritz, a Zebrafish atonal Homolog. 
  • Retinoid-related orphan receptor gamma (RORgamma) is essential for lymphoid organogenesis and controls apoptosis during thymopoiesis. 
  • Retrospective family study of childhood medulloblastoma. 
  • Rev7 loss alters cisplatin response and increases drug efficacy in chemotherapy-resistant lung cancer. 
  • Revealing A-T and G-C Hoogsteen base pairs in stressed protein-bound duplex DNA. 
  • Reversal of apoptosis by the leukaemia-associated E2A-HLF chimaeric transcription factor. 
  • Reversal of physiological stress-induced resistance to topoisomerase II inhibitors using an inducible phosphorylation site-deficient mutant of I kappa B alpha. 
  • Reversible inhibition of Hsp70 chaperone function by Scythe and Reaper. 
  • Revised structure of the AbrB N-terminal domain unifies a diverse superfamily of putative DNA-binding proteins. 
  • Rewiring of Signaling Networks Modulating Thermotolerance in the Human Pathogen Cryptococcus neoformans. 
  • Rhabdoid tumour: a malignancy of early childhood with variable primary site, histology and clinical behaviour. 
  • Role for E2F in control of both DNA replication and mitotic functions as revealed from DNA microarray analysis. 
  • Role for ETS domain transcription factors Pea3/Erm in mouse lung development. 
  • Role of MotA transcription factor in bacteriophage T4 DNA replication. 
  • Role of T-bet in commitment of TH1 cells before IL-12-dependent selection. 
  • Role of cAMP-dependent protein kinase in controlling aggregation and postaggregative development in Dictyostelium. 
  • Role of decreased levels of lipid phosphate phosphatase-1 in accumulation of lysophosphatidic acid in ovarian cancer. 
  • Role of mismatch repair in the fidelity of RAD51- and RAD59-dependent recombination in Saccharomyces cerevisiae. 
  • Role of transforming growth factor Beta in human cancer. 
  • Roles for the winged helix transcription factors MF1 and MFH1 in cardiovascular development revealed by nonallelic noncomplementation of null alleles. 
  • Roles of ATM and NBS1 in chromatin structure modulation and DNA double-strand break repair. 
  • Roles of CCAAT/enhancer-binding proteins in regulation of liver regenerative growth. 
  • Roles of RAD6 epistasis group members in spontaneous polzeta-dependent translesion synthesis in Saccharomyces cerevisiae. 
  • Roles of v-erbA homodimers and heterodimers in mediating dominant negative activity by v-erbA. 
  • Runx2/Cbfa1-genetically engineered skeletal myoblasts mineralize collagen scaffolds in vitro. 
  • SB-431542, a small molecule transforming growth factor-beta-receptor antagonist, inhibits human glioma cell line proliferation and motility. 
  • SET alpha and SET beta mRNA isoforms in chronic lymphocytic leukaemia. 
  • SET oncoprotein overexpression in B-cell chronic lymphocytic leukemia and non-Hodgkin lymphoma: a predictor of aggressive disease and a new treatment target. 
  • SINAT E3 Ligases Control the Light-Mediated Stability of the Brassinosteroid-Activated Transcription Factor BES1 in Arabidopsis. 
  • SMRTER, a Drosophila nuclear receptor coregulator, reveals that EcR-mediated repression is critical for development. 
  • SOCS36E, a novel Drosophila SOCS protein, suppresses JAK/STAT and EGF-R signalling in the imaginal wing disc. 
  • SOS induction as an in vivo assay of enzyme-DNA interactions. 
  • SSBP1 mutations cause mtDNA depletion underlying a complex optic atrophy disorder. 
  • STAT-3 overexpression and p21 up-regulation accompany impaired regeneration of fatty livers. 
  • STAT1 is essential for antimicrobial effector function but dispensable for gamma interferon production during Toxoplasma gondii infection. 
  • SV40 enhancer-binding factors are required at the establishment but not the maintenance step of enhancer-dependent transcriptional activation. 
  • Sec63 and Xbp1 regulate IRE1α activity and polycystic disease severity. 
  • Secondary structure of a leucine zipper determined by nuclear magnetic resonance spectroscopy. 
  • Secreted nuclear protein DEK regulates hematopoiesis through CXCR2 signaling. 
  • Segregation of atrial-specific and inducible expression of an atrial natriuretic factor transgene in an in vivo murine model of cardiac hypertrophy. 
  • Selective Autophagy of BES1 Mediated by DSK2 Balances Plant Growth and Survival. 
  • Selective induction of CCAAT/enhancer binding protein isoforms occurs during rat liver development. 
  • Self-assembled Lipid Nanoparticles for Ratiometric Codelivery of Cisplatin and siRNA Targeting XPF to Combat Drug Resistance in Lung Cancer. 
  • Senataxin mutations elicit motor neuron degeneration phenotypes and yield TDP-43 mislocalization in ALS4 mice and human patients. 
  • Sensing and Processing of DNA Interstrand Crosslinks by the Mismatch Repair Pathway. 
  • Sensitivity of temporal excitation properties to the neuronal element activated by extracellular stimulation. 
  • Separate domains of the Ran GTPase interact with different factors to regulate nuclear protein import and RNA processing. 
  • Sequence composition and context effects on the generation and repair of frameshift intermediates in mononucleotide runs in Saccharomyces cerevisiae. 
  • Sequence variations in DNA repair gene XPC is associated with lung cancer risk in a Chinese population: a case-control study. 
  • Sequences that direct rat tyrosine hydroxylase gene expression. 
  • Sequestration of a dual function DNA-binding protein by Vibrio cholerae CRP. 
  • Serine/threonine phosphorylation regulates HNF-4alpha-dependent redox-mediated iNOS expression in hepatocytes. 
  • Seven-up inhibits ultraspiracle-based signaling pathways in vitro and in vivo. 
  • Sex in the 90s: SRY and the switch to the male pathway. 
  • Shared genetic pathways contribute to the tolerance of endogenous and low-dose exogenous DNA damage in yeast. 
  • Signaling role of hemocytes in Drosophila JAK/STAT-dependent response to septic injury. 
  • Signaling via LAT (linker for T-cell activation) and Syk/ZAP70 is required for ERK activation and NFAT transcriptional activation following CD2 stimulation. 
  • Significant effect of homologous recombination DNA repair gene polymorphisms on pancreatic cancer survival. 
  • Simian virus 40 (SV40) T antigen binds specifically to double-stranded DNA but not to single-stranded DNA or DNA/RNA hybrids containing the SV40 regulatory sequences. 
  • Single cell analysis reveals distinct immune landscapes in transplant and primary sarcomas that determine response or resistance to immunotherapy. 
  • Single nucleotide polymorphisms of RecQ1, RAD54L, and ATM genes are associated with reduced survival of pancreatic cancer. 
  • Single-cell imaging of T cell immunotherapy responses in vivo. 
  • Sir2 suppresses transcription-mediated displacement of Mcm2-7 replicative helicases at the ribosomal DNA repeats. 
  • Six1 and Six1 cofactor expression is altered during early skeletal muscle overload in mice. 
  • Smad3 deficiency attenuates bleomycin-induced pulmonary fibrosis in mice. 
  • Smad3 has a critical role in TGF-beta-mediated growth inhibition and apoptosis in colonic epithelial cells. 
  • Smad3-Smad4 and AP-1 complexes synergize in transcriptional activation of the c-Jun promoter by transforming growth factor beta. 
  • Smad5 induces ventral fates in Xenopus embryo. 
  • Smads "freeze" when they ski. 
  • Smads bind directly to the Jun family of AP-1 transcription factors. 
  • Small Cell Lung Cancer Exhibits Frequent Inactivating Mutations in the Histone Methyltransferase KMT2D/MLL2: CALGB 151111 (Alliance). 
  • Small contribution of G1 checkpoint control manipulation to modulation of p53-mediated apoptosis. 
  • Sok2 regulates yeast pseudohyphal differentiation via a transcription factor cascade that regulates cell-cell adhesion. 
  • Solution NMR structure of the N-terminal domain of the human DEK protein. 
  • Solution structure of the core NFATC1/DNA complex. 
  • Somatic Mutation Allelic Ratio Test Using ddPCR (SMART-ddPCR): An Accurate Method for Assessment of Preferential Allelic Imbalance in Tumor DNA. 
  • Somatic mutation of hPMS2 as a possible cause of sporadic human colon cancer with microsatellite instability. 
  • Somatic mutations in the chromatin remodeling gene ARID1A occur in several tumor types. 
  • Sox2 is required for development of taste bud sensory cells. 
  • Sox8 is expressed at similar levels in gonads of both sexes during the sex determining period in turtles. 
  • SoxNeuro and Shavenbaby act cooperatively to shape denticles in the embryonic epidermis of Drosophila . 
  • Sp and GATA factors are critical for Apolipoprotein AI downstream enhancer activity in human HepG2 cells. 
  • Sp1, but not Sp3, functions to mediate promoter activation by TGF-beta through canonical Sp1 binding sites. 
  • Spatiotemporal analysis identifies ABF2 and ABF3 as key hubs of endodermal response to nitrate. 
  • Special issue on engineered DNA-binding proteins. 
  • Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival. 
  • Spermatogenesis and the regulation of Ca(2+)-calmodulin-dependent protein kinase IV localization are not dependent on calspermin. 
  • Spontaneous expression of antibodies to DNA of various species origin in sera of normal subjects and patients with systemic lupus erythematosus. 
  • Sry and the testis: molecular pathways of organogenesis. 
  • Sry induces cell proliferation in the mouse gonad. 
  • Stable interaction between beta-arrestin 2 and angiotensin type 1A receptor is required for beta-arrestin 2-mediated activation of extracellular signal-regulated kinases 1 and 2. 
  • Staggered cell-intrinsic timing of ath5 expression underlies the wave of ganglion cell neurogenesis in the zebrafish retina. 
  • Stat3 activation regulates the expression of matrix metalloproteinase-2 and tumor invasion and metastasis. 
  • Stat3 activation regulates the expression of vascular endothelial growth factor and human pancreatic cancer angiogenesis and metastasis. 
  • Stemness Is Enhanced in Gastric Cancer by a SET/PP2A/E2F1 Axis. 
  • Steroid induction of therapy-resistant cytokeratin-5-positive cells in estrogen receptor-positive breast cancer through a BCL6-dependent mechanism. 
  • Steroidal and triterpenoidal fungal metabolites as ligands of liver X receptors. 
  • Steroidogenic factor 1 (SF-1) is essential for endocrine development and function. 
  • Steroidogenic factor 1 (SF-1) is essential for ovarian development and function. 
  • Steroidogenic factor 1 and Dax-1 colocalize in multiple cell lineages: potential links in endocrine development. 
  • Steroidogenic factor 1 is the essential transcript of the mouse Ftz-F1 gene. 
  • Steroidogenic factor 1 plays multiple roles in endocrine development and function. 
  • Steroidogenic factor 1: an essential mediator of endocrine development. 
  • Stimulation of GCMa transcriptional activity by cyclic AMP/protein kinase A signaling is attributed to CBP-mediated acetylation of GCMa. 
  • Stimulation of calcineurin signaling attenuates the dystrophic pathology in mdx mice. 
  • Stimulation of different subtypes of angiotensin II receptors, AT1 and AT2 receptors, regulates STAT activation by negative crosstalk. 
  • Stoichiometries of protein-protein/DNA binding and conformational changes for the transition-state regulator AbrB measured by pseudo cell-size exclusion chromatography-mass spectrometry. 
  • Stress proteins and cardiovascular disease. 
  • Structural analysis of the purine repressor, an Escherichia coli DNA-binding protein. 
  • Structural and biochemical characterization of MepR, a multidrug binding transcription regulator of the Staphylococcus aureus multidrug efflux pump MepA. 
  • Structural basis for allosteric control of the transcription regulator CcpA by the phosphoprotein HPr-Ser46-P. 
  • Structural basis of DNA-protein recognition. 
  • Structural basis of JAZ repression of MYC transcription factors in jasmonate signalling. 
  • Structural basis of core promoter recognition in a primitive eukaryote. 
  • Structural basis of multidrug recognition by BmrR, a transcription activator of a multidrug transporter. 
  • Structural biology of plasmid partition: uncovering the molecular mechanisms of DNA segregation. 
  • Structural mechanism for the fine-tuning of CcpA function by the small molecule effectors glucose 6-phosphate and fructose 1,6-bisphosphate. 
  • Structural mechanism of ATP-induced polymerization of the partition factor ParF: implications for DNA segregation. 
  • Structure and DNA-binding traits of the transition state regulator AbrB. 
  • Structure and function of the UvrB protein. 
  • Structure and regulation of the mouse ing1 gene. Three alternative transcripts encode two phd finger proteins that have opposite effects on p53 function. 
  • Structure and stability of monomeric lambda repressor: NMR evidence for two-state folding. 
  • Structure of FitAB from Neisseria gonorrhoeae bound to DNA reveals a tetramer of toxin-antitoxin heterodimers containing pin domains and ribbon-helix-helix motifs. 
  • Structure of the Rad50 x Mre11 DNA repair complex from Saccharomyces cerevisiae by electron microscopy. 
  • Structure of the genes encoding transcription factor IIB and TATA box-binding protein from Drosophila melanogaster. 
  • Structures of carbon catabolite protein A-(HPr-Ser46-P) bound to diverse catabolite response element sites reveal the basis for high-affinity binding to degenerate DNA operators. 
  • Structures of maintenance of carboxysome distribution Walker-box McdA and McdB adaptor homologs. 
  • Structures of the Escherichia coli transcription activator and regulator of diauxie, XylR: an AraC DNA-binding family member with a LacI/GalR ligand-binding domain. 
  • Structures of the nucleoid occlusion protein SlmA bound to DNA and the C-terminal domain of the cytoskeletal protein FtsZ. 
  • Submillisecond folding of monomeric lambda repressor. 
  • Substitutions in bacteriophage T4 AsiA and Escherichia coli sigma(70) that suppress T4 motA activation mutations. 
  • Substrate availability and transcriptional regulation of metabolic genes in human skeletal muscle during recovery from exercise. 
  • Substrate specificities and identification of putative substrates of ATM kinase family members. 
  • Suppression of CHK1 by ETS Family Members Promotes DNA Damage Response Bypass and Tumorigenesis. 
  • Suppression of DNA-damage checkpoint signaling by Rsk-mediated phosphorylation of Mre11. 
  • Suppression of Rev3, the catalytic subunit of Pol{zeta}, sensitizes drug-resistant lung tumors to chemotherapy. 
  • Suppression of tumorigenesis and induction of p15(ink4b) by Smad4/DPC4 in human pancreatic cancer cells. 
  • Survey of variation in human transcription factors reveals prevalent DNA binding changes. 
  • Survival prediction in patients with glioblastoma multiforme by human telomerase genetic variation. 
  • Synergic effect of OP449 and FTY720 on oral squamous cell carcinoma. 
  • Synergistic interactions between heterologous upstream activation elements and specific TATA sequences in a muscle-specific promoter. 
  • Synthesis of programmable integrases. 
  • Synthetic lethality by targeting EZH2 methyltransferase activity in ARID1A-mutated cancers. 
  • Synthetic zinc finger proteins: the advent of targeted gene regulation and genome modification technologies. 
  • Systemic acquired resistance. 
  • Systemic transforming growth factor-beta1 gene therapy induces Foxp3+ regulatory cells, restores self-tolerance, and facilitates regeneration of beta cell function in overtly diabetic nonobese diabetic mice. 
  • TET2 Deficiency Sets the Stage for B-cell Lymphoma. 
  • TET2 binds the androgen receptor and loss is associated with prostate cancer. 
  • TET2 mutations improve the new European LeukemiaNet risk classification of acute myeloid leukemia: a Cancer and Leukemia Group B study. 
  • TGF-beta-induced phosphorylation of Smad3 regulates its interaction with coactivator p300/CREB-binding protein. 
  • TOR mutations confer rapamycin resistance by preventing interaction with FKBP12-rapamycin. 
  • TRPC3 channels confer cellular memory of recent neuromuscular activity. 
  • Tagging single nucleotide polymorphisms in excision repair cross-complementing group 1 (ERCC1) and risk of primary lung cancer in a Chinese population. 
  • Tandem mass spectrometry acquisition approaches to enhance identification of protein-protein interactions using low-energy collision-induced dissociative chemical crosslinking reagents. 
  • Targeted disruption of Smad3 reveals an essential role in transforming growth factor beta-mediated signal transduction. 
  • Targeted ubiquitination of CDT1 by the DDB1-CUL4A-ROC1 ligase in response to DNA damage. 
  • Targeting A20 decreases glioma stem cell survival and tumor growth. 
  • Targeting SET/I(2)PP2A oncoprotein functions as a multi-pathway strategy for cancer therapy. 
  • Targeting inhibitors of the tumor suppressor PP2A for the treatment of pancreatic cancer. 
  • Targeting lysosomal degradation induces p53-dependent cell death and prevents cancer in mouse models of lymphomagenesis. 
  • Targeting the ATM Kinase to Enhance the Efficacy of Radiotherapy and Outcomes for Cancer Patients. 
  • Targets of immunophilin-immunosuppressant complexes are distinct highly conserved regions of calcineurin A. 
  • Telomerase activity is restored in human cells by ectopic expression of hTERT (hEST2), the catalytic subunit of telomerase. 
  • Telomerase mRNA-transfected dendritic cells stimulate antigen-specific CD8+ and CD4+ T cell responses in patients with metastatic prostate cancer. 
  • Template-based docking of a prolactin receptor proline-rich motif octapeptide to FKBP12: implications for cytokine receptor signaling. 
  • Tethering telomeric double- and single-stranded DNA-binding proteins inhibits telomere elongation. 
  • Tetramerization and single-stranded DNA binding properties of native and mutated forms of murine mitochondrial single-stranded DNA-binding proteins. 
  • The "dispensable" portion of RAG2 is necessary for efficient V-to-DJ rearrangement during B and T cell development. 
  • The 58-kda microspherule protein (MSP58) represses human telomerase reverse transcriptase (hTERT) gene expression and cell proliferation by interacting with telomerase transcriptional element-interacting factor (TEIF). 
  • The 9-1-1 checkpoint clamp physically interacts with polzeta and is partially required for spontaneous polzeta-dependent mutagenesis in Saccharomyces cerevisiae. 
  • The AIM2 inflammasome is activated in astrocytes during the late phase of EAE. 
  • The AP2/ERF Transcription Factor TINY Modulates Brassinosteroid-Regulated Plant Growth and Drought Responses in Arabidopsis. 
  • The ATM-dependent DNA damage signaling pathway. 
  • The Cancer Genome Atlas Comprehensive Molecular Characterization of Renal Cell Carcinoma. 
  • The CovR response regulator of group A streptococcus (GAS) acts directly to repress its own promoter. 
  • The Cryptococcus neoformans Rim101 transcription factor directly regulates genes required for adaptation to the host. 
  • The DNA binding domain of a papillomavirus E2 protein programs a chimeric nuclease to cleave integrated human papillomavirus DNA in HeLa cervical carcinoma cells. 
  • The DNA damage- and transcription-associated protein paxip1 controls thymocyte development and emigration. 
  • The DNA repair protein, O(6)-methylguanine-DNA methyltransferase is a proteolytic target for the E6 human papillomavirus oncoprotein. 
  • The DNA-binding protein Hdf1p (a putative Ku homologue) is required for maintaining normal telomere length in Saccharomyces cerevisiae. 
  • The Drosophila BEAF insulator protein interacts with the polybromo subunit of the PBAP chromatin remodeling complex. 
  • The F-box E3 ubiquitin ligase BAF1 mediates the degradation of the brassinosteroid-activated transcription factor BES1 through selective autophagy in Arabidopsis. 
  • The GBP1 microcapsule interferes with IcsA-dependent septin cage assembly around Shigella flexneri. 
  • The Genetic Basis of Hepatosplenic T-cell Lymphoma. 
  • The HSF-like transcription factor TBF1 is a major molecular switch for plant growth-to-defense transition. 
  • The Histone Methyltransferase Ash1l is Required for Epidermal Homeostasis in Mice. 
  • The Hypersaline Archaeal Histones HpyA and HstA Are DNA Binding Proteins That Defy Categorization According to Commonly Used Functional Criteria. 
  • The MODY1 gene HNF-4alpha regulates selected genes involved in insulin secretion. 
  • The Maf transcription factors: regulators of differentiation. 
  • The MerR-like protein BldC binds DNA direct repeats as cooperative multimers to regulate Streptomyces development. 
  • The Mitochondrial Phosphatase PGAM5 Is Dispensable for Necroptosis but Promotes Inflammasome Activation in Macrophages. 
  • The MotA protein from bacteriophage T4 contains two domains. Preliminary structural analysis by X-ray diffraction and nuclear magnetic resonance. 
  • The MotA transcriptional activator of bacteriophage T4 binds to its specific DNA site as a monomer. 
  • The Mre11p/Rad50p/Xrs2p complex and the Tel1p function in a single pathway for telomere maintenance in yeast. 
  • The MutSalpha-proliferating cell nuclear antigen interaction in human DNA mismatch repair. 
  • The N-terminal Set-β Protein Isoform Induces Neuronal Death. 
  • The NF-E2 transcription factor. 
  • The Oct-2 transcription factor represses tyrosine hydroxylase expression via a heptamer TAATGARAT-like motif in the gene promoter. 
  • The Phycomyces madA gene encodes a blue-light photoreceptor for phototropism and other light responses. 
  • The Primary Effect on the Proteome of ARID1A-mutated Ovarian Clear Cell Carcinoma is Downregulation of the Mevalonate Pathway at the Post-transcriptional Level. 
  • The Rad50S allele promotes ATM-dependent DNA damage responses and suppresses ATM deficiency: implications for the Mre11 complex as a DNA damage sensor. 
  • The Smads: transcriptional regulation and mouse models. 
  • The Solution Structures and Interaction of SinR and SinI: Elucidating the Mechanism of Action of the Master Regulator Switch for Biofilm Formation in Bacillus subtilis. 
  • The Sox10(Dom) mouse: modeling the genetic variation of Waardenburg-Shah (WS4) syndrome. 
  • The Staphylococcus aureus pSK41 plasmid-encoded ArtA protein is a master regulator of plasmid transmission genes and contains a RHH motif used in alternate DNA-binding modes. 
  • The Structure of the Biofilm-controlling Response Regulator BfmR from Acinetobacter baumannii Reveals Details of Its DNA-binding Mechanism. 
  • The TFAP2A-IRF6-GRHL3 genetic pathway is conserved in neurulation. 
  • The accessible chromatin landscape of the human genome. 
  • The activation domain of the MotA transcription factor from bacteriophage T4. 
  • The adenovirus E4orf6 protein inhibits DNA double strand break repair and radiosensitizes human tumor cells in an E1B-55K-independent manner. 
  • The bZIP transcription factor LCR-F1 is essential for mesoderm formation in mouse development. 
  • The basic helix-loop-helix domain of the aryl hydrocarbon receptor nuclear transporter (ARNT) can oligomerize and bind E-box DNA specifically. 
  • The battle of the sexes. 
  • The bromodomain protein Brd4 insulates chromatin from DNA damage signalling. 
  • The carboxyl-terminal repeat domain of RNA polymerase II is not required for transcription factor Sp1 to function in vitro. 
  • The cell-specific nuclear receptor steroidogenic factor 1 plays multiple roles in reproductive function. 
  • The chromatin-binding protein Smyd1 restricts adult mammalian heart growth. 
  • The coiled coils of cohesin are conserved in animals, but not in yeast. 
  • The crystal structure of the Escherichia coli MobA protein provides insight into molybdopterin guanine dinucleotide biosynthesis. 
  • The cyclophilin-like domain mediates the association of Ran-binding protein 2 with subunits of the 19 S regulatory complex of the proteasome. 
  • The downstream core promoter element, DPE, is conserved from Drosophila to humans and is recognized by TAFII60 of Drosophila. 
  • The energy landscape of a fast-folding protein mapped by Ala-->Gly substitutions. 
  • The forkhead genes, Foxc1 and Foxc2, regulate paraxial versus intermediate mesoderm cell fate. 
  • The forkhead/winged helix gene Mf1 is disrupted in the pleiotropic mouse mutation congenital hydrocephalus. 
  • The forkhead/winged-helix gene, Mf1, is necessary for the normal development of the cornea and formation of the anterior chamber in the mouse eye. 
  • The function of gamma interferon-inducible GTP-binding protein IGTP in host resistance to Toxoplasma gondii is Stat1 dependent and requires expression in both hematopoietic and nonhematopoietic cellular compartments. 
  • The function of multiple IkappaB : NF-kappaB complexes in the resistance of cancer cells to Taxol-induced apoptosis. 
  • The gene SCL is expressed during early hematopoiesis and encodes a differentiation-related DNA-binding motif. 
  • The gene coding for the Hrp pilus structural protein is required for type III secretion of Hrp and Avr proteins in Pseudomonas syringae pv. tomato. 
  • The genetic landscape of mutations in Burkitt lymphoma. 
  • The genetic landscape of the childhood cancer medulloblastoma. 
  • The genome's best friend. 
  • The genomic landscape of familial glioma. 
  • The genomic landscape of mantle cell lymphoma is related to the epigenetically determined chromatin state of normal B cells. 
  • The growth-dependent expression of angiotensin II type 2 receptor is regulated by transcription factors interferon regulatory factor-1 and -2. 
  • The helix-loop-helix gene E2A is required for B cell formation. 
  • The helix-turn-helix DNA binding motif. 
  • The high mobility group protein Abf2p influences the level of yeast mitochondrial DNA recombination intermediates in vivo. 
  • The histone deacetylase HDAC4 connects neural activity to muscle transcriptional reprogramming. 
  • The homeodomain protein HOXB13 regulates the cellular response to androgens. 
  • The human TTP protein: sequence, alignment with related proteins, and chromosomal localization of the mouse and human genes. 
  • The human fetal lymphocyte lineage: identification by CD27 and LIN28B expression in B cell progenitors. 
  • The immunosuppressant FK506 and its nonimmunosuppressive analog L-685,818 are toxic to Cryptococcus neoformans by inhibition of a common target protein. 
  • The loss of Smad3 results in a lower rate of bone formation and osteopenia through dysregulation of osteoblast differentiation and apoptosis. 
  • The many substrates and functions of ATM. 
  • The mechanism of RU486 antagonism is dependent on the conformation of the carboxy-terminal tail of the human progesterone receptor. 
  • The mismatch DNA repair heterodimer, hMSH2/6, regulates BLM helicase. 
  • The multisubunit IkappaB kinase complex shows random sequential kinetics and is activated by the C-terminal domain of IkappaB alpha. 
  • The murine winged helix transcription factors, Foxc1 and Foxc2, are both required for cardiovascular development and somitogenesis. 
  • The myoD gene family: nodal point during specification of the muscle cell lineage. 
  • The nuclear DEK interactome supports multi-functionality. 
  • The nuclear corepressors NCoR and SMRT are key regulators of both ligand- and 8-bromo-cyclic AMP-dependent transcriptional activity of the human progesterone receptor. 
  • The nuclear receptor steroidogenic factor 1 acts at multiple levels of the reproductive axis. 
  • The nuclear receptor steroidogenic factor 1 is essential for the formation of the ventromedial hypothalamic nucleus. 
  • The nucleocapsid region of HIV-1 Gag cooperates with the PTAP and LYPXnL late domains to recruit the cellular machinery necessary for viral budding. 
  • The nucleolar localization domain of the catalytic subunit of human telomerase. 
  • The nucleotide messenger (p)ppGpp is an anti-inducer of the purine synthesis transcription regulator PurR in Bacillus. 
  • The numbers of individual mitochondrial DNA molecules and mitochondrial DNA nucleoids in yeast are co-regulated by the general amino acid control pathway. 
  • The oncocytic subtype is genetically distinct from other pancreatic intraductal papillary mucinous neoplasm subtypes. 
  • The opposing transcriptional activities of the two isoforms of the human progesterone receptor are due to differential cofactor binding. 
  • The order and logic of CD4 versus CD8 lineage choice and differentiation in mouse thymus. 
  • The pathological role of NLRs and AIM2 inflammasome-mediated pyroptosis in damaged blood-brain barrier after traumatic brain injury. 
  • The phage T4 protein UvsW drives Holliday junction branch migration. 
  • The polyphony of BACH2. 
  • The polypyrimidine tract binding protein is required for efficient picornavirus gene expression and propagation. 
  • The potential repertoire of the innate immune system in the bladder: expression of pattern recognition receptors in the rat bladder and a rat urothelial cell line (MYP3 cells). 
  • The presence of human papillomavirus-16/-18 E6, p53, and Bcl-2 protein in cervicovaginal smears from patients with invasive cervical cancer. 
  • The protein kinase Tor1 regulates adhesin gene expression in Candida albicans. 
  • The role and regulation of mTOR in T-lymphocyte function. 
  • The role of EVI1 in myeloid malignancies. 
  • The role of Smad3 in mediating mouse hepatic stellate cell activation. 
  • The role of Sry in cellular events underlying mammalian sex determination. 
  • The role of modulatory calcineurin-interacting proteins in calcineurin signaling. 
  • The role of the transcription factor ETV5 in insulin exocytosis. 
  • The roles of steroidogenic factor-1 in reproductive function. 
  • The scaffold protein WRAP53β orchestrates the ubiquitin response critical for DNA double-strand break repair. 
  • The structural distribution of cooperative interactions in proteins: analysis of the native state ensemble. 
  • The structural mechanism for transcription activation by MerR family member multidrug transporter activation, N terminus. 
  • The structure of PurR mutant L54M shows an alternative route to DNA kinking. 
  • The structure of a CREB bZIP.somatostatin CRE complex reveals the basis for selective dimerization and divalent cation-enhanced DNA binding. 
  • The telomeric protein TRF2 binds the ATM kinase and can inhibit the ATM-dependent DNA damage response. 
  • The tor pathway regulates gene expression by linking nutrient sensing to histone acetylation. 
  • The transcription factor B-Myb is maintained in an inhibited state in target cells through its interaction with the nuclear corepressors N-CoR and SMRT. 
  • The transcriptional integrator CREB-binding protein mediates positive cross talk between nuclear hormone receptors and the hematopoietic bZip protein p45/NF-E2. 
  • The transcriptional repressor Bcl-6 directs T follicular helper cell lineage commitment. 
  • The ubiquitous subunit of erythroid transcription factor NF-E2 is a small basic-leucine zipper protein related to the v-maf oncogene. 
  • The winged helix gene, Mf3, is required for normal development of the diencephalon and midbrain, postnatal growth and the milk-ejection reflex. 
  • The winged helix transcription factor MFH1 is required for proliferation and patterning of paraxial mesoderm in the mouse embryo. 
  • The winged-helix DNA-binding motif: another helix-turn-helix takeoff. 
  • The winged-helix/forkhead protein myocyte nuclear factor beta (MNF-beta) forms a co-repressor complex with mammalian sin3B. 
  • The zinc finger cluster domain of RanBP2 is a specific docking site for the nuclear export factor, exportin-1. 
  • Therapeutic applications of transcription factor decoy oligonucleotides. 
  • Thermodynamic stability measurements on multimeric proteins using a new H/D exchange- and matrix-assisted laser desorption/ionization (MALDI) mass spectrometry-based method. 
  • Three-dimensional structure of the developing mouse genital ridge. 
  • Thymic expression of the transcription factor Nur77 rescues the T cell but not the B cell abnormality of gld/gld mice. 
  • Time-restricted feeding mitigates obesity through adipocyte thermogenesis. 
  • To oxidize or not to oxidize? 
  • Topoisomerase II: its functions and phosphorylation. 
  • Transcription factor AP-2 regulates human immunodeficiency virus type 1 gene expression. 
  • Transcription factor E2-2 is an essential and specific regulator of plasmacytoid dendritic cell development. 
  • Transcription factor NF-kappaB regulates inducible CD83 gene expression in activated T lymphocytes. 
  • Transcription factor Nrg1 mediates capsule formation, stress response, and pathogenesis in Cryptococcus neoformans. 
  • Transcription factor decoy to study the molecular mechanism of negative regulation of renin gene expression in the liver in vivo. 
  • Transcriptional attenuation following cAMP induction requires PP-1-mediated dephosphorylation of CREB. 
  • Transcriptional control of preadipocyte determination by Zfp423. 
  • Transcriptional regulation of the cholesteryl ester transfer protein gene by the orphan nuclear hormone receptor apolipoprotein AI regulatory protein-1. 
  • Transcriptional repressor functions of Drosophila E2F1 and E2F2 cooperate to inhibit genomic DNA synthesis in ovarian follicle cells. 
  • Transferrin receptor 1 is differentially required in lymphocyte development. 
  • Transforming growth factor beta 1 dysregulation in a human oral carcinoma tumour progression model. 
  • Transforming growth factor beta-mediated transcriptional repression of c-myc is dependent on direct binding of Smad3 to a novel repressive Smad binding element. 
  • Transforming growth factor-beta signaling in cancer. 
  • Transforming growth factor-beta-mediated p15(INK4B) induction and growth inhibition in astrocytes is SMAD3-dependent and a pathway prominently altered in human glioma cell lines. 
  • Transforming growth factor-beta1 inhibition of vascular smooth muscle cell activation is mediated via Smad3. 
  • Transient expression of a winged-helix protein, MNF-beta, during myogenesis. 
  • Transient inhibition of ATM kinase is sufficient to enhance cellular sensitivity to ionizing radiation. 
  • Transient requirement for ganglion cells during assembly of retinal synaptic layers. 
  • Triiodothyronine (T3) differentially affects T3-receptor/retinoic acid receptor and T3-receptor/retinoid X receptor heterodimer binding to DNA. 
  • Triple-hit B-cell Lymphoma With MYC, BCL2, and BCL6 Translocations/Rearrangements: Clinicopathologic Features of 11 Cases. 
  • Tumor necrosis factor alpha promotes nuclear localization of cytokine-inducible CCAAT/enhancer binding protein isoforms in hepatocytes. 
  • Tumor necrosis factor-alpha modulates CCAAT/enhancer binding proteins-DNA binding activities and promotes hepatocyte-specific gene expression during liver regeneration. 
  • Tumor necrosis factor-alpha stimulates the maturation of sterol regulatory element binding protein-1 in human hepatocytes through the action of neutral sphingomyelinase. 
  • Tumor suppressor Smad4 is a transforming growth factor beta-inducible DNA binding protein. 
  • Tumor suppressor gene Smad4/DPC4, its downstream target genes, and regulation of cell cycle. 
  • Two forms of NF-kappa B1 (p105/p50) in murine macrophages: differential regulation by lipopolysaccharide, interleukin-2, and interferon-gamma. 
  • Two molecularly distinct G(2)/M checkpoints are induced by ionizing irradiation. 
  • Two novel TP63 mutations associated with the ankyloblepharon, ectodermal defects, and cleft lip and palate syndrome: a skin fragility phenotype. 
  • Type 2 diabetes: evidence for linkage on chromosome 20 in 716 Finnish affected sib pairs. 
  • USP6 oncogene promotes Wnt signaling by deubiquitylating Frizzleds. 
  • Ubiquitin-binding site 2 of ataxin-3 prevents its proteasomal degradation by interacting with Rad23. 
  • Ubiquitin-mediated degradation a mechanism for fine-tuning TGF-beta signaling. 
  • Ultrabithorax function in butterfly wings and the evolution of insect wing patterns. 
  • Uncertainty in the utility of immunohistochemistry in mismatch repair protein expression in epithelial ovarian cancer. 
  • Uncoupling of the signaling and caspase-inhibitory properties of X-linked inhibitor of apoptosis. 
  • Unusual Rel-like architecture in the DNA-binding domain of the transcription factor NFATc. 
  • Unusual chromosome architecture and behaviour at an HSR. 
  • Unveiling the secrets to her heart. 
  • Unwinding the Role of FACT in Cas9-based Genome Editing. 
  • Up-regulation of GRP78 and antiapoptotic signaling in murine peritoneal macrophages exposed to insulin. 
  • Up-regulation of tumor susceptibility gene 101 conveys poor prognosis through suppression of p21 expression in ovarian cancer. 
  • Update on late relapse of germ cell tumor: a clinical and molecular analysis. 
  • Upregulation of VEGF-C by androgen depletion: the involvement of IGF-IR-FOXO pathway. 
  • Upregulation of miR21 and repression of Grhl3 by leptin mediates sinusoidal endothelial injury in experimental nonalcoholic steatohepatitis. 
  • Upstream stimulatory factors are mediators of Ca2+-responsive transcription in neurons. 
  • Use of genetically modified mouse models for evaluation of carcinogenic risk: considerations for the laboratory animal scientist. 
  • Use of phage display to identify novel mineralocorticoid receptor-interacting proteins. 
  • Usefulness of translocation-associated immunohistochemical stains in the fine-needle aspiration diagnosis of salivary gland neoplasms. 
  • Using Bcr-Abl to examine mechanisms by which abl kinase regulates morphogenesis in Drosophila. 
  • V(D)J recombinase activity in a subset of germinal center B lymphocytes. 
  • VHL Deficiency Drives Enhancer Activation of Oncogenes in Clear Cell Renal Cell Carcinoma. 
  • Vaccination of cancer patients against telomerase induces functional antitumor CD8+ T lymphocytes. 
  • Validating genetic risk associations for ovarian cancer through the international Ovarian Cancer Association Consortium. 
  • Validating the meta-analytical results on MDM2, CASP8, XRCC3 polymorphisms and breast cancer risk: examination of Hardy-Weinberg Equilibrium. 
  • Vanadium-induced STAT-1 activation in lung myofibroblasts requires H2O2 and P38 MAP kinase. 
  • Variability on the dot chromosome in the Drosophila simulans clade. 
  • Variable Extent of Lineage-Specificity and Developmental Stage-Specificity of Cohesin and CCCTC-Binding Factor Binding Within the Immunoglobulin and T Cell Receptor Loci. 
  • Variants in Notch signalling pathway genes, PSEN1 and MAML2, predict overall survival in Chinese patients with epithelial ovarian cancer. 
  • Variants in nucleotide excision repair core genes and susceptibility to recurrence of squamous cell carcinoma of the oropharynx. 
  • Variations in Prkdc and susceptibility to benzene-induced toxicity in mice. 
  • Vasculitis as a Major Morbidity Factor in Patients With Partial RAG Deficiency. 
  • Visualization of replication initiation and elongation in Drosophila. 
  • Vitamin D receptors repress basal transcription and exert dominant negative activity on triiodothyronine-mediated transcriptional activity. 
  • Vitamin D status of black and white Americans and changes in vitamin D metabolites after varied doses of vitamin D supplementation. 
  • Vitamin E succinate inhibits human prostate cancer cell growth via modulating cell cycle regulatory machinery. 
  • WT1 and DAX-1 inhibit aromatase P450 expression in human endometrial and endometriotic stromal cells. 
  • WT1 and DAX-1 regulate SF-1-mediated human P450arom gene expression in gonadal cells. 
  • Warming Induces Significant Reprogramming of Beige, but Not Brown, Adipocyte Cellular Identity. 
  • When is a transcription factor a NAP? 
  • Whole genome sequencing reveals novel IGHMBP2 variant leading to unique cryptic splice-site and Charcot-Marie-Tooth phenotype with early onset symptoms. 
  • Whole-exome sequencing of neoplastic cysts of the pancreas reveals recurrent mutations in components of ubiquitin-dependent pathways. 
  • Whole-genome comparison of Leu3 binding in vitro and in vivo reveals the importance of nucleosome occupancy in target site selection. 
  • Why newborn screening for severe combined immunodeficiency is essential: a case report. 
  • Widespread activation of the DNA damage response in human pancreatic intraepithelial neoplasia. 
  • Wnt signalling shows its versatility. 
  • X-ray repair cross-complementing group 1 (XRCC1) single-nucleotide polymorphisms and the risk of salivary gland carcinomas. 
  • XPA polymorphism associated with reduced lung cancer risk and a modulating effect on nucleotide excision repair capacity. 
  • XPD/ERCC2 EXON 8 Polymorphisms: rarity and lack of significance in risk of squamous cell carcinoma of the head and neck. 
  • XPD/ERCC2 polymorphisms and risk of head and neck cancer: a case-control analysis. 
  • XRCC1 polymorphisms and cancer risk: a meta-analysis of 38 case-control studies. 
  • XRCC2 and XRCC3 gene polymorphism and risk of pancreatic cancer. 
  • XRCC3 Thr241Met polymorphism and breast cancer risk: a meta-analysis. 
  • XRCC3 haplotypes and risk of gliomas in a Chinese population: a hospital-based case-control study. 
  • Yeast base excision repair: interconnections and networks. 
  • ZBTB7A promotes virus-host homeostasis during human coronavirus 229E infection. 
  • ZFP423 controls EBF2 coactivator recruitment and PPARγ occupancy to determine the thermogenic plasticity of adipocytes. 
  • ZTF-8 interacts with the 9-1-1 complex and is required for DNA damage response and double-strand break repair in the C. elegans germline. 
  • Zfp36l3, a rodent X chromosome gene encoding a placenta-specific member of the Tristetraprolin family of CCCH tandem zinc finger proteins. 
  • Zfp423 Maintains White Adipocyte Identity through Suppression of the Beige Cell Thermogenic Gene Program. 
  • Zfp423 expression identifies committed preadipocytes and localizes to adipose endothelial and perivascular cells. 
  • Zinc finger protein binding to DNA: an energy perspective using molecular dynamics simulation and free energy calculations on mutants of both zinc finger domains and their specific DNA bases. 
  • Zinc inhibits turnover of labile mRNAs in intact cells. 
  • beta-Arrestin1 modulates lymphoid enhancer factor transcriptional activity through interaction with phosphorylated dishevelled proteins. 
  • c-Myb and core-binding factor/PEBP2 display functional synergy but bind independently to adjacent sites in the T-cell receptor delta enhancer. 
  • c-Myc creates an activation loop by transcriptionally repressing its own functional inhibitor, hMad4, in young fibroblasts, a loop lost in replicatively senescent fibroblasts. 
  • c-di-GMP Arms an Anti-σ to Control Progression of Multicellular Differentiation in Streptomyces. 
  • cAMP-dependent protein kinase is necessary for increased NF-E2.DNA complex formation during erythroleukemia cell differentiation. 
  • cAMP-response element modulator tau is a positive regulator of testis angiotensin converting enzyme transcription. 
  • hEST2, the putative human telomerase catalytic subunit gene, is up-regulated in tumor cells and during immortalization. 
  • hMad4, c-Myc endogenous inhibitor, induces a replicative senescence-like state when overexpressed in human fibroblasts. 
  • hMutSalpha- and hMutLalpha-dependent phosphorylation of p53 in response to DNA methylator damage. 
  • hSnm1B is a novel telomere-associated protein. 
  • mTOR coordinates transcriptional programs and mitochondrial metabolism of activated Treg subsets to protect tissue homeostasis. 
  • miR-17-92 cluster targets phosphatase and tensin homology and Ikaros Family Zinc Finger 4 to promote TH17-mediated inflammation. 
  • mirror encodes a novel PBX-class homeoprotein that functions in the definition of the dorsal-ventral border in the Drosophila eye. 
  • p16 Inactivation in pancreatic intraepithelial neoplasias (PanINs) arising in patients with chronic pancreatitis. 
  • p45 NF-E2 regulates expression of thromboxane synthase in megakaryocytes. 
  • p53 and ATM: cell cycle, cell death, and cancer. 
  • p53 regulates the expression of the tumor suppressor gene maspin. 
  • p53: a two-faced cancer gene. 
  • p63 expression profile in normal and malignant prostate epithelial cells. 
  • p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities. 
  • p73 G4C14-to-A4T14 gene polymorphism and interaction with p53 exon 4 Arg72Pro on cancer susceptibility: a meta-analysis of the literature. 
  • p73 G4C14-to-A4T14 polymorphism and risk of human papillomavirus-associated squamous cell carcinoma of the oropharynx in never smokers and never drinkers. 
  • p73 G4C14-to-A4T14 polymorphism and risk of lung cancer. 
  • p73 G4C14-to-A4T14 polymorphism and risk of second primary malignancy after index squamous cell carcinoma of head and neck. 
  • uORF-mediated translation allows engineered plant disease resistance without fitness costs. 
  • ¹H, ¹³C, and ¹⁵N resonance assignments and secondary structure prediction of the full-length transition state regulator AbrB from Bacillus anthracis. 
  • βarrestin-1 regulates DNA repair by acting as an E3-ubiquitin ligase adaptor for 53BP1. 
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  Keywords of People

  • Bejsovec, Amy, Associate Professor of Biology, Biology
  • Berchuck, Andrew, James M. Ingram Distinguished Professor of Gynecologic Oncology, Obstetrics and Gynecology, Gynecologic Oncology
  • Bobay, Benjamin, Assistant Professor in Radiology, Radiology
  • Ciofani, Maria, Associate Professor of Integrative Immunobiology, Cell Biology
  • Erickson, Harold Paul, James B. Duke Distinguished Professor Emeritus, Cell Biology
  • Ferreira, Paulo Alexandre, Associate Professor in Ophthalmology, Pathology
  • Gordan, Raluca Mihaela, Associate Professor in Biostatistics & Bioinformatics, Computer Science
  • Hartemink, Alexander J., Professor in the Department of Computer Science, Biology
  • Hilton, Matthew James, Associate Professor in Orthopaedic Surgery, Cell Biology
  • Krangel, Michael S., George Barth Geller Distinguished Professor of Immunology, Integrative Immunobiology
  • Linardic, Corinne Mary, Associate Professor of Pediatrics, Cell Biology
  • Luftig, Micah Alan, Professor of Molecular Genetics and Microbiology, Cell Biology
  • McDonnell, Donald Patrick, Glaxo-Wellcome Distinguished Professor of Molecular Cancer Biology, in the School of Medicine, Cell Biology
  • McLendon, Roger Edwin, Professor of Pathology, Pathology
  • Moorman, Patricia Gripka, Professor Emeritus in Family Medicine and Community Health, Duke Cancer Institute
  • Reddy, Timothy E, Associate Professor of Biostatistics & Bioinformatics,, Molecular Genetics and Microbiology
  • Schmid, Amy K., David M. Goodner Associate Professor, Duke Science & Society
  • Sullivan, Beth Ann, Professor of Molecular Genetics and Microbiology, Duke Science & Society
  • Wray, Gregory Allan, Professor of Biology, Evolutionary Anthropology