DNA, Neoplasm

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  Subject Areas on Research

  • 5-[211 At]astato-2'-deoxyuridine, an alpha particle-emitting endoradiotherapeutic agent undergoing DNA incorporation. 
  • A functional isoform of the human granulocyte/macrophage colony-stimulating factor receptor has an unusual cytoplasmic domain. 
  • A map of human cancer signaling. 
  • A natural history of melanoma: serial gene expression analysis. 
  • A neural survival factor is a candidate oncogene in breast cancer. 
  • A phase II study of capecitabine, oxaliplatin, bevacizumab and cetuximab in the treatment of metastatic colorectal cancer. 
  • A single tube, four-color flow cytometry assay for evaluation of ZAP-70 and CD38 expression in chronic lymphocytic leukemia. 
  • A statistic for comparing two correlated markers which are prognostic for time to an event. 
  • A transcriptional repressor of osteopontin expression in the 4T1 murine breast cancer cell line. 
  • APC promoter hypermethylation contributes to the loss of APC expression in colorectal cancers with allelic loss on 5q. 
  • Aberrant expression of cell-cycle regulatory proteins in human mesenchymal neoplasia. 
  • Aberrant splicing of the TSG101 tumor suppressor gene in human breast and ovarian cancers. 
  • Abnormal expression of cell cycle regulatory proteins in ductal and lobular carcinomas of the breast. 
  • Absence of a correlation of androgen receptor gene CAG repeat length and prostate cancer risk in an African-American population. 
  • Absence of somatic changes in p21 gene in non-Hodgkin's lymphoma and chronic myelogenous leukemia. 
  • Absent ras gene mutations in human adrenal cortical neoplasms and pheochromocytomas. 
  • Allele loss on chromosome 1p36 in epithelial ovarian cancers. 
  • Allelotype analysis of uterine leiomyoma: localization of a potential tumor suppressor gene to a 4-cM region of chromosome 7q. 
  • Alteration of the tumor suppressor gene p53 in a high fraction of hormone refractory prostate cancer. 
  • Amplification of telomeric DNA directly correlates with metastatic potential of human and murine cancers of various histological origin. 
  • Amplification of the c-myc gene in human medulloblastoma cell lines and xenografts. 
  • An efficient multiple-exposure analysis of the toxicity of crisnatol, a DNA intercalator in phase II clinical trials. 
  • An in vitro assay procedure to test chemotherapeutic drugs on cells from human solid tumors. 
  • Analysis of alterations of oncogenes and tumor suppressor genes in chronic lymphocytic leukemia. 
  • Analysis of genetic alterations in uterine leiomyomas and leiomyosarcomas by comparative genomic hybridization. 
  • Androgen receptor mutations in androgen-independent prostate cancer: Cancer and Leukemia Group B Study 9663. 
  • Aneuploid subpopulations in tumour-invaded lymph nodes from breast cancer patients. 
  • Array CGH profiling of favourable histology Wilms tumours reveals novel gains and losses associated with relapse. 
  • Array comparative genomic hybridisation (aCGH) analysis of premenopausal breast cancers from a nuclear fallout area and matched cases from Western New York. 
  • Assessment of pancreatic duct strictures. 
  • Association between ratio of matrix metalloproteinase-1 to tissue inhibitor of metalloproteinase-1 and local recurrence, metastasis, and survival in human chondrosarcoma. 
  • Association of IL-1β -511 polymorphism with severe veno-occlusive disease in pediatric-matched allogeneic hematopoietic stem cell transplantation. 
  • Association of chromosome 11 locus D11S12 with histology, stage, and metastases in lung cancer. 
  • BRCA1 expression is induced before DNA synthesis in both normal and tumor-derived breast cells. 
  • BRCA1 maps proximal to D17S579 on chromosome 17q21 by genetic analysis. 
  • Bayesian analysis of binary prediction tree models for retrospectively sampled outcomes. 
  • Bilateral diffuse uveal melanocytic proliferation associated with pancreatic carcinoma: a case report and literature review of this paraneoplastic syndrome. 
  • Biphasic malignant meningioma: a comparative genomic hybridization study. 
  • CDKN2 in HPV-positive and HPV-negative cervical-carcinoma cell lines. 
  • CDKN2A promoter methylation in gastric adenocarcinomas: clinical variables. 
  • Cell cycle kinetic effects of tamoxifen on human breast cancer cells. Flow cytometric analyses of DNA content, BrdU labeling, Ki-67, PCNA, and statin expression. 
  • Characterization of the DNase I hypersensitive site 3' of the human beta globin gene domain. 
  • Characterization of the epidermal growth factor receptor in human glioma cell lines and xenografts. 
  • Chemotherapy-induced apoptosis in epithelial ovarian cancers. 
  • Cholera toxin and cell growth: role of membrane gangliosides. 
  • Chromosomal aberrations of primary lung adenocarcinomas in nonsmokers. 
  • Chromosome 3 analysis of uveal melanoma using fine-needle aspiration biopsy at the time of plaque radiotherapy in 140 consecutive cases. 
  • Chromosome 3 analysis of uveal melanoma using fine-needle aspiration biopsy at the time of plaque radiotherapy in 140 consecutive cases: the Deborah Iverson, MD, Lectureship. 
  • Clinical performance and utility of a DNA methylation urine test for bladder cancer. 
  • Clinical pharmacodynamics of high-dose methotrexate in acute lymphocytic leukemia. Identification of a relation between concentration and effect. 
  • Clonal origin of epithelial ovarian carcinoma: analysis by loss of heterozygosity, p53 mutation, and X-chromosome inactivation. 
  • Common variants within 6p21.31 locus are associated with chronic lymphocytic leukaemia and, potentially, other non-Hodgkin lymphoma subtypes. 
  • Common variation in Nemo-like kinase is associated with risk of ovarian cancer. 
  • Comparison of fluorescence in situ hybridization, cytogenetic analysis, and DNA index analysis to detect chromosomes 4 and 10 aneuploidy in pediatric acute lymphoblastic leukemia: a Pediatric Oncology Group study. 
  • Comprehensive DNA copy number profiling of meningioma using a chromosome 1 tiling path microarray identifies novel candidate tumor suppressor loci. 
  • Comprehensive, Integrative Genomic Analysis of Diffuse Lower-Grade Gliomas. 
  • Correlation of DNA ploidy and histologic diagnosis from prostate core-needle biopsies: is DNA ploidy more sensitive than histology for the diagnosis of carcinoma in small specimens? 
  • Cytoplasmic and/or nuclear accumulation of the beta-catenin protein is a frequent event in human osteosarcoma. 
  • Cytotoxicity of alpha-particle-emitting 5-[211At]astato-2'-deoxyuridine in human cancer cells. 
  • DNA in radical prostatectomy specimens. Prognostic value of tumor ploidy. 
  • DNA interstrand crosslinking and strand break repair in human glioma cell lines of varying [1,3-bis(2-chloroethyl)-1-nitrosourea] resistance. 
  • DNA methylation and ovarian cancer. I. Analysis of CpG island hypermethylation in human ovarian cancer using differential methylation hybridization. 
  • DNA mismatch repair and O6-alkylguanine-DNA alkyltransferase analysis and response to Temodal in newly diagnosed malignant glioma. 
  • DNA ploidy in nonseminomatous germ cell testicular tumor. 
  • DNA ploidy of malignant melanoma determined by image cytometry of fresh frozen and paraffin-embedded tissue. 
  • Detection of BRCA1 mutations in women with early-onset ovarian cancer by use of the protein truncation test. 
  • Detection of DNA damage in transcriptionally active genes by RT-PCR and assessment of repair of cisplatin-induced damage in the glutathione S-transferase-pi gene in human glioblastoma cells. 
  • Detection of clonal lymphoid receptor gene rearrangements in langerhans cell histiocytosis. 
  • Detection of frequent allelic loss on proximal chromosome 17q in sporadic breast carcinoma using microsatellite length polymorphisms. 
  • Detection of mutated c-Ki-ras in the bile of patients with pancreatic cancer. 
  • Dideoxy fingerprinting assay for BRCA1 mutation analysis. 
  • Differential gene expression patterns in HER2/neu-positive and -negative breast cancer cell lines and tissues. 
  • Differential inactivation of CDKN2 and Rb protein in non-small-cell and small-cell lung cancer cell lines. 
  • Differing molecular pathology of pancreatic adenocarcinoma in Egyptian and United States patients. 
  • Dual role of glutathione in modulating camptothecin activity: depletion potentiates activity, but conjugation enhances the stability of the topoisomerase I-DNA cleavage complex. 
  • Electric field-mediated transport of plasmid DNA in tumor interstitium in vivo. 
  • Endogenous expression of transforming growth factor beta1 inhibits growth and tumorigenicity and enhances Fas-mediated apoptosis in a murine high-grade glioma model. 
  • Epidermal growth factor receptor gene analysis in renal cell carcinoma. 
  • Epigenetic silencing of genes in human colon cancer. 
  • Epstein-Barr virus in gastric adenocarcinomas: association with ethnicity and CDKN2A promoter methylation. 
  • Establishment and characterization of a new human prostatic carcinoma cell line (DuPro-1). 
  • Estrogen receptor alpha (ESR1) mutant A908G is not a common feature in benign and malignant proliferations of the breast. 
  • Etiology of the mutational spectrum of ras genes in human carcinomas. 
  • Evaluation of microsatellite instability, hMLH1 expression and hMLH1 promoter hypermethylation in defining the MSI phenotype of colorectal cancer. 
  • Expression of osteocalcin and its transcriptional regulators core-binding factor alpha 1 and MSX2 in osteoid-forming tumours. 
  • Flow cytometric DNA analysis of interleukin-2 responsive renal cell carcinoma. 
  • Flow cytometric analysis of comedocarcinoma of the prostate: an uncommon histopathological variant of prostatic adenocarcinoma. 
  • Flow cytometric and quantitative histological parameters to predict occult disease in clinical stage I nonseminomatous testicular germ cell tumors. 
  • Flow cytometric assessment of deoxyribonucleic acid content in renal adenocarcinoma: does ploidy status enhance prognostic stratification over stage alone? 
  • Flow cytometric determination of ploidy in prostatic adenocarcinoma: a comparison with seminal vesicle involvement and histopathological grading as a predictor of clinical recurrence. 
  • Flow cytometry as a predictive indicator in patients with operable gastric cancer. 
  • Formation and repair of 1,3-bis-(2-chloroethyl)-1-nitrosourea and cisplatin induced total genomic DNA interstrand crosslinks in human glioma cells. 
  • Frequency of homozygous deletion at p16/CDKN2 in primary human tumours. 
  • Frequent IGF2/H19 domain epigenetic alterations and elevated IGF2 expression in epithelial ovarian cancer. 
  • Frequent detection of bcl-2/JH translocations in human blood and organ samples by a quantitative polymerase chain reaction assay. 
  • Frequent detection of codon 877 mutation in the androgen receptor gene in advanced prostate cancers. 
  • Frequent loss of heterozygosity on chromosome arm 18q in squamous cell carcinomas. Identification of 2 regions of loss--18q11.1-q12.3 and 18q21.1-q23. 
  • Genetic basis for p53 overexpression in human breast cancer. 
  • Genetic changes in contralateral bronchioloalveolar carcinomas of the lung. 
  • Genetic heterogeneity of diffuse large B-cell lymphoma. 
  • Genomic sweeping for hypermethylated genes. 
  • Genotypic analysis of tumor suppressor genes PTEN/MMAC1 and p53 in head and neck squamous cell carcinomas. 
  • Glioma Groups Based on 1p/19q, IDH, and TERT Promoter Mutations in Tumors. 
  • Global search for chromosomal abnormalities in infiltrating ductal carcinoma of the breast using array-comparative genomic hybridization. 
  • Glutathione content and glutathione-S-transferase expression in 1,3-bis(2-chloroethyl)-1-nitrosourea-resistant human malignant astrocytoma cell lines. 
  • Glutathione-associated cis-diamminedichloroplatinum(II) metabolism and ATP-dependent efflux from leukemia cells. Molecular characterization of glutathione-platinum complex and its biological significance. 
  • Ha-ras polymorphisms in epithelial ovarian cancer. 
  • High-throughput detection of glutathione s-transferase polymorphic alleles in a pediatric cancer population. 
  • Histologic grade, DNA ploidy, and intraglandular tumor extent as indicators of tumor progression of clinical stage B prostatic carcinoma. A direct comparison. 
  • Human Dkk-1, a gene encoding a Wnt antagonist, responds to DNA damage and its overexpression sensitizes brain tumor cells to apoptosis following alkylation damage of DNA. 
  • Humoral immunostimulation. IV. Role of complement. 
  • Identification of candidate genes in ulcerative colitis and Crohn's disease using cDNA array technology. 
  • Identification of p18 INK4c as a tumor suppressor gene in glioblastoma multiforme. 
  • Identification of resting cells by dual-parameter flow cytometry of statin expression and DNA content. 
  • Identification of the breast cancer susceptibility gene BRCA2. 
  • Immunohistochemical [corrected] detection of the alternate INK4a-encoded tumor suppressor protein p14(ARF) in archival human cancers and cell lines using commercial antibodies: correlation with p16(INK4a) expression. 
  • Immunohistochemical and genetic analysis of non-small cell and small cell gallbladder carcinoma and their precursor lesions. 
  • Immunohistochemical p16INK4a analysis of archival tumors with deletion, hypermethylation, or mutation of the CDKN2/MTS1 gene. A comparison of four commercial antibodies. 
  • In vitro and in vivo molecular evidence of genistein action in augmenting the efficacy of cisplatin in pancreatic cancer. 
  • In vitro determination of thymidine-3H labeling index in human solid tumors. 
  • Induction of apoptosis by diethylstilbestrol in hormone-insensitive prostate cancer cells. 
  • Induction of transformational changes in normal endothelial cells by cultured human astrocytoma cells. 
  • Inhibition of DNA synthesis and enhancement of the uptake and action of methotrexate by low-power-density microwave radiation in L1210 leukemia cells. 
  • Insulin-like growth factor binding protein-3 induces early apoptosis in malignant prostate cancer cells and inhibits tumor formation in vivo. 
  • Intra-tumoral heterogeneity of gemcitabine delivery and mass transport in human pancreatic cancer. 
  • Intratumoral heterogeneity in primary breast carcinoma: study of concurrent parameters. 
  • LIN28B polymorphisms influence susceptibility to epithelial ovarian cancer. 
  • Loss of heterozygosity at chromosome segment Xq25-26.1 in advanced human ovarian carcinomas. 
  • M6P/IGF2 receptor: a candidate breast tumor suppressor gene. 
  • MEN1 gene mutation analysis of high-grade neuroendocrine lung carcinoma. 
  • MYCC and MYCN oncogene amplification in medulloblastoma. A fluorescence in situ hybridization study on paraffin sections from the Children's Oncology Group. 
  • Maintenance of DNA content and erbB-2 alterations in intraductal and invasive phases of mammary cancer. 
  • Mathematical modeling of folate metabolism: predicted effects of genetic polymorphisms on mechanisms and biomarkers relevant to carcinogenesis. 
  • Mechanism of the anti-tumour effect of biochemotherapy in melanoma: preliminary results. 
  • Microarray sampling-platform fabrication using bubble-jet technology for a biochip system. 
  • Microsatellite instability in gynecological sarcomas and in hMSH2 mutant uterine sarcoma cell lines defective in mismatch repair activity. 
  • Modulation of cyclophosphamide activity by O6-alkylguanine-DNA alkyltransferase. 
  • Molecular biologic staging of lung cancer. 
  • Molecular evidence for increased antitumor activity of gemcitabine by genistein in vitro and in vivo using an orthotopic model of pancreatic cancer. 
  • Monoclonal antibodies for brain tumour treatment. 
  • Monoclonal antibody against human T cell leukemia virus p19 defines a human thymic epithelial antigen acquired during ontogeny. 
  • Multicolor in vitro translation. 
  • Multiple DNA repair mechanisms and alkylator resistance in the human medulloblastoma cell line D-283 Med (4-HCR). 
  • Multiple gastrin-releasing peptide gene-associated peptides are produced by a human small cell lung cancer line. 
  • Mutation analysis of the THRA1 gene in breast cancer: deletion/fusion of the gene to a novel sequence on 17q in the BT474 cell line. 
  • Mutation and overexpression of p53 in early-stage epithelial ovarian cancer. 
  • Mutation and overexpression of the p53 tumor suppressor gene frequently occurs in uterine and ovarian sarcomas. 
  • Mutation of MSH3 in endometrial cancer and evidence for its functional role in heteroduplex repair. 
  • Mutational analysis of the estrogen-receptor gene in endometrial carcinoma. 
  • Mutational analysis of the p21/WAF1/CIP1/SDI1 coding region in human tumor cell lines. 
  • Mutations of PIK3CA in anaplastic oligodendrogliomas, high-grade astrocytomas, and medulloblastomas. 
  • Mutations of the E-cadherin gene in human gynecologic cancers. 
  • Mutations of the p16 gene product are rare in prostate cancer. 
  • Nanoscale chromatin profiling of gastric adenocarcinoma reveals cancer-associated cryptic promoters and somatically acquired regulatory elements. 
  • Network-Based Integration of GWAS and Gene Expression Identifies a HOX-Centric Network Associated with Serous Ovarian Cancer Risk. 
  • Nuclear DNA content of clear cell adenocarcinoma of the vagina and cervix and its relationship to prognosis. 
  • Nuclear DNA study of vaginal and cervical squamous cell abnormalities in DES exposed progeny. 
  • Oncogenic mutations in melanomas and benign melanocytic nevi of the female genital tract. 
  • Overexpression and mutation of p53 in epithelial ovarian cancer. 
  • PTEN gene mutations are seen in high-grade but not in low-grade gliomas. 
  • Participation of p53 protein in the cellular response to DNA damage. 
  • Performance of amplified DNA in an Illumina GoldenGate BeadArray assay. 
  • Persistent genetic instability in cancer cells induced by non-DNA-damaging stress exposures. 
  • Phase I clinical and plasma and cellular pharmacological study of topotecan without and with granulocyte colony-stimulating factor. 
  • Ploidy analysis of epithelial ovarian cancers using image cytometry. 
  • Polymorphic repeats in the androgen receptor gene: molecular markers of prostate cancer risk. 
  • Precise localization of the FHIT gene to the common fragile site at 3p14.2 (FRA3B) and characterization of homozygous deletions within FRA3B that affect FHIT transcription in tumor cell lines. 
  • Prevalence of HTLV-I-associated T-cell lymphoma. 
  • Primary intraocular T-cell-rich large B-cell lymphoma. 
  • Prognostic factors in renal cancer. 
  • Prognostic significance of DNA ploidy in carcinoma of prostate. 
  • Prognostic value of MIB-1 in advanced ovarian carcinoma as determined using automated immunohistochemistry and quantitative image analysis. 
  • Quantitative detection of RASSF1A DNA promoter methylation in tumors and serum of patients with serous epithelial ovarian cancer. 
  • Recombinant adenovirus vector expressing wild-type p53 is a potent inhibitor of prostate cancer cell proliferation. 
  • Regulation of tumor necrosis factor cytotoxicity by calcineurin. 
  • Repair analysis of 4-hydroperoxycyclophosphamide-induced DNA interstrand crosslinking in the c-myc gene in 4-hydroperoxycyclophosphamide-sensitive and -resistant medulloblastoma cell lines. 
  • Risk factors for cancer. 
  • Risk factors for ovarian cancers with and without microsatellite instability. 
  • Risk of adverse events in children completing treatment for acute lymphoblastic leukemia: St. Jude Total Therapy studies VIII, IX, and X. 
  • Simultaneous detection of the tumor suppressor FHIT gene and protein using the multi-functional biochip. 
  • Small changes in expression affect predisposition to tumorigenesis. 
  • Small choroidal melanoma with chromosome 3 monosomy on fine-needle aspiration biopsy. 
  • Somatic Mutation Allelic Ratio Test Using ddPCR (SMART-ddPCR): An Accurate Method for Assessment of Preferential Allelic Imbalance in Tumor DNA. 
  • Somatic deletion of the neurofibromatosis type 1 gene in a neurofibrosarcoma supports a tumour suppressor gene hypothesis. 
  • Strand-specific mismatch correction in nuclear extracts of human and Drosophila melanogaster cell lines. 
  • Structural and functional properties of the "hairy" cells of leukemic reticuloendotheliosis. 
  • Structure of the human allelic glutathione S-transferase-pi gene variant, hGSTP1 C, cloned from a glioblastoma multiforme cell line. 
  • Studies on the enhanced interaction of halodeoxyuridine-substituted DNAs with H1 histones and other polypeptides. 
  • Studies on the mechanism of the synergistic interaction between 2'-deoxy-5-azacytidine and cisplatin. 
  • Suppression of tumorigenicity of A549 lung adenocarcinoma cells by human chromosomes 3 and 11 introduced via microcell-mediated chromosome transfer. 
  • Syndrome of inappropriate secretion of antidiuretic hormone in a patient with carcinoma of the nasopharynx. 
  • Synergistic cytotoxicity using 2'-deoxy-5-azacytidine and cisplatin or 4-hydroperoxycyclophosphamide with human tumor cells. 
  • Synergistic cytotoxicity with 2'-deoxy-5-azacytidine and topotecan in vitro and in vivo. 
  • Synergistic interactions between cyclophosphamide or melphalan and VP-16 in a human rhabdomyosarcoma xenograft. 
  • Telomerase activity in normal leukocytes and in hematologic malignancies. 
  • The DNA-repair gene MGMT and the clinical response of gliomas to alkylating agents. 
  • The isolation and characterization of a novel cDNA demonstrating an altered mRNA level in nontumorigenic Wilms' microcell hybrid cells. 
  • The nuclear factor-kappa B RelA transcription factor is constitutively activated in human pancreatic adenocarcinoma cells. 
  • The p53 signal transduction pathway is intact in human neuroblastoma despite cytoplasmic localization. 
  • The pathology of liver-localized post-transplant lymphoproliferative disease: a report of three cases and a review of the literature. 
  • The pattern of gene amplification is determined by the chromosomal location of hairpin-capped breaks. 
  • Transient inhibition of ATM kinase is sufficient to enhance cellular sensitivity to ionizing radiation. 
  • Two identical triplet sisters carrying a germline BRCA1 gene mutation acquire very similar breast cancer somatic mutations at multiple other sites throughout the genome. 
  • Type 1 neurofibromatosis gene: identification of a large transcript disrupted in three NF1 patients. 
  • Use of laser scanning cytometry to study tumor microenvironment. 
  • [A study of epithelial cell kinetics of the odontogenic keratocyst]. 
  • cDNA sequencing confirms HTLV-I expression in adult T-cell leukemia/lymphoma and different sequence variations in vivo and in vitro. 
  • p16 Improves interobserver agreement in diagnosis of anal intraepithelial neoplasia. 
  • p53 gene alterations in human prostate carcinoma. 
  • p53 gene expression in node-positive breast cancer: relationship to DNA ploidy and prognosis. 
  • p53 status in spontaneous and dimethylnitrosamine-induced renal cell tumors from rats. 
  • rac, a novel ras-related family of proteins that are botulinum toxin substrates. 
  • ras mutations and expression in head and neck squamous cell carcinomas. 
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  Keywords of People

  • Bennett, Vann, George B. Geller Professor for Research in Molecular Biology in the School of Medicine, Duke Cancer Institute
  • Berchuck, Andrew, James M. Ingram Professor of Gynecologic Oncology, Obstetrics and Gynecology, Gynecologic Oncology
  • Halabi, Susan, Professor of Biostatistics and Bioinformatics, Biostatistics & Bioinformatics
  • Luftig, Micah Alan, Associate Professor of Molecular Genetics and Microbiology, Molecular Genetics and Microbiology
  • McLendon, Roger Edwin, Professor of Pathology, Pathology
  • Pang, Herbert, Adjunct Assistant Professor in the Department of Biostatistics and Bioinformatics, Biostatistics & Bioinformatics
  • Yan, Hai, Henry S. Friedman Professor of Neuro-Oncology in the School of Medicine, Pathology