Subject Areas on Research
- A mutation of the yeast gene encoding PCNA destabilizes both microsatellite and minisatellite DNA sequences.
- Alpha satellite DNA biology: finding function in the recesses of the genome.
- Analysis of Drosophila melanogaster satellite IV with restriction endonuclease MboII.
- Analytical DNA fingerprinting in lions: parentage, genetic diversity, and kinship.
- Atomic resolution cryo-EM structure of a native-like CENP-A nucleosome aided by an antibody fragment.
- Blepharophimosis syndrome is linked to chromosome 3q.
- Centromeres of human chromosomes.
- Characterization of neo-centromeres in marker chromosomes lacking detectable alpha-satellite DNA.
- Cytological evidence of transcription of highly repeated DNA sequences during the lampbrush stage in Triturus cristatus carnifex.
- Demographic study of a wild house sparrow population by DNA fingerprinting.
- Detection of frequent allelic loss on proximal chromosome 17q in sporadic breast carcinoma using microsatellite length polymorphisms.
- Development of a microsatellite genetic map spanning 5q31-q33 and subsequent placement of the LGMD1A locus between D5S178 and IL9.
- Distal nephron renal tumors: microsatellite allelotype.
- Diverse hypermutability of multiple expressed sequence motifs present in a cancer with microsatellite instability.
- Elevated frequency of microsatellite mutations in TK6 human lymphoblast clones selected for mutations at the thymidine kinase locus.
- Evidence for structural heterogeneity from molecular cytogenetic analysis of dicentric Robertsonian translocations.
- Frequency of homozygous deletion at p16/CDKN2 in primary human tumours.
- Genetic instability of microsatellites in endometrial carcinoma.
- Genetic mapping of dinucleotide repeat polymorphisms and von Hippel-Lindau disease on chromosome 3p25-26.
- Genomic size of CENP-A domain is proportional to total alpha satellite array size at human centromeres and expands in cancer cells.
- Genomic variation within alpha satellite DNA influences centromere location on human chromosomes with metastable epialleles.
- Histone gene clusters of the newt notophthalmus are separated by long tracts of satellite DNA.
- Human Centromeres Produce Chromosome-Specific and Array-Specific Alpha Satellite Transcripts that Are Complexed with CENP-A and CENP-C.
- Human centromere repositioning within euchromatin after partial chromosome deletion.
- Human centromeric chromatin is a dynamic chromosomal domain that can spread over noncentromeric DNA.
- Human gamma-satellite DNA maintains open chromatin structure and protects a transgene from epigenetic silencing.
- Identification and mapping of type 1 neurofibromatosis (NF1) homologous loci.
- Improved genetic fingerprinting using RNA probes.
- Instability of simple sequence repeats in a mammalian cell line.
- Linkage of Tunisian autosomal recessive Duchenne-like muscular dystrophy to the pericentromeric region of chromosome 13q.
- Microsatellite analysis of childhood brain tumors.
- Microsatellite instability in gynecological sarcomas and in hMSH2 mutant uterine sarcoma cell lines defective in mismatch repair activity.
- Mismatch repair deficiency in phenotypically normal human cells.
- Mutations in the MSH3 gene preferentially lead to deletions within tracts of simple repetitive DNA in Saccharomyces cerevisiae.
- North Carolina macular dystrophy: exclusion map using RFLPs and microsatellites.
- Probable exclusion of GLC1A as a candidate glaucoma gene in a family with middle-age-onset primary open-angle glaucoma.
- Satellite DNA is transcribed on lampbrush chromosomes.
- Structural and functional dynamics of human centromeric chromatin.
- Telomere disruption results in non-random formation of de novo dicentric chromosomes involving acrocentric human chromosomes.
- Telomere-to-telomere assembly of a complete human X chromosome.
- The evolutionary dynamics of alpha-satellite.
- The forkhead transcription factor FoxI1 remains bound to condensed mitotic chromosomes and stably remodels chromatin structure.
- α satellite DNA variation and function of the human centromere.
Keywords of People
- Berchuck, Andrew, James M. Ingram Distinguished Professor of Gynecologic Oncology, Obstetrics and Gynecology, Gynecologic Oncology
- Sullivan, Beth Ann, Professor of Molecular Genetics and Microbiology, Duke Science & Society
- Wray, Gregory Allan, Professor of Biology, Evolutionary Anthropology