DNA, Single-Stranded

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  Subject Areas on Research

  • A role for immunogenic DNA in the pathogenesis of systemic lupus erythematosus. 
  • Association of the viral reverse transcriptase with an enzyme degrading the RNA moiety of RNA-DNA hybrids. 
  • Bacteriophage T4 UvsW protein is a helicase involved in recombination, repair and the regulation of DNA replication origins. 
  • Bacteriophage T4 helicase loader protein gp59 functions as gatekeeper in origin-dependent replication in vivo. 
  • Binding specificity of a monoclonal anti-DNA antibody. 
  • Biocatalytic microcontact printing. 
  • Biochemistry. Scaling up DNA computation. 
  • Breakage of single-stranded DNA by eukaryotic type 1 topoisomerase occurs only at regions with the potential for base-pairing. 
  • Breakage of single-stranded DNA by rat liver nicking-closing enzyme with the formation of a DNA-enzyme complex. 
  • Carbon monoxide promotes hypoxic pulmonary vascular remodeling. 
  • Cellular requirements for anti-DNA production induced in mice by immunization with bacterial DNA. 
  • Characterization of antibodies to bacterial double-stranded DNA in the sera of normal human subjects. 
  • Characterization of the cystic fibrosis transmembrane conductance regulator promoter region. Chromatin context and tissue-specificity. 
  • Cloning and characterization of rat-brain-specific transcripts: rare, brain-specific transcripts and tyrosine hydroxylase. 
  • Cocrystal structure of an editing complex of Klenow fragment with DNA. 
  • Comparative studies on the secondary structure of ovalbumin messenger RNA and its complementary DNA transcript. 
  • Conformational transition of DNA induced by cationic lipid vesicle in acidic solution: spectroscopy investigation. 
  • Cutting of M13mp7 phage DNA and excision of cloned single-stranded sequences by restriction endonucleases. 
  • Cytosine deamination in mismatched base pairs. 
  • DNA breakage and closure by rat liver type 1 topoisomerase: separation of the half-reactions by using a single-stranded DNA substrate. 
  • DNA sequencing: detecting methylation with force. 
  • DNA strand breakage by wheat germ type 1 topoisomerase. 
  • DNA structural features that lead to strand breakage by eukaryotic type-I topoisomerase. 
  • DNA-XPA interactions: a (31)P NMR and molecular modeling study of dCCAATAACC association with the minimal DNA-binding domain (M98-F219) of the nucleotide excision repair protein XPA. 
  • Dissociation of radiation-induced phosphorylation of replication protein A from the S-phase checkpoint. 
  • Distinct functions of POT1 at telomeres. 
  • Duplication of single stranded DNA catalyzed by calf thymus DNA polymerase alpha. 
  • Effect of cytofectins on the immune response of murine macrophages to mammalian DNA. 
  • Effect of sex on the induction of anti-DNA antibodies in normal mice immunized with bacterial DNA. 
  • Enzymatic polymerization of high molecular weight DNA amphiphiles that self-assemble into star-like micelles. 
  • Exposure of mice to topical bovine thrombin induces systemic autoimmunity. 
  • Expression of IgM and IgG autoantibodies in pediatric and adult systemic lupus erythematosus. 
  • Expression, purification, and in vitro assays of mitochondrial single-stranded DNA-binding protein. 
  • Fabrication of ssDNA/oligo(ethylene glycol) monolayers and complex nanostructures by an irradiation-promoted exchange reaction. 
  • Function of the hydrophilic carboxyl terminus of type II DNA topoisomerase from Drosophila melanogaster. I. In vitro studies. 
  • Gene A of X174. 1. Isolation and identification of its products. 
  • Genetic control of inflammatory arthritis in congenic lpr mice. 
  • Genetic subtyping of human immunodeficiency virus using a heteroduplex mobility assay. 
  • Genomic deletions and point mutations induced in Saccharomyces cerevisiae by the trinucleotide repeats (GAA·TTC) associated with Friedreich's ataxia. 
  • Helper T cell subsets for immunoglobulin A responses: oral immunization with tetanus toxoid and cholera toxin as adjuvant selectively induces Th2 cells in mucosa associated tissues. 
  • High-Frequency Illegitimate Strand Transfers of Nascent DNA Fragments During Reverse Transcription Result in Defective Retrovirus Genomes. 
  • Hydrolysis of template and newly synthesized deoxyribonucleic acid by the 3' to 5' exonuclease activity of the T4 deoxyribonucleic acid polymerase. 
  • Identification of cellular proteins required for simian virus 40 DNA replication. 
  • Immune recognition of DNA in SLE. 
  • Immunochemical properties of anti-DNA antibodies in the sera of patients with Escherichia coli bacteremia. 
  • Immunological properties of bacterial DNA. 
  • In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. III. The kinetics of V region mutation and selection in germinal center B cells. 
  • Induction of immune-mediated glomerulonephritis in normal mice immunized with bacterial DNA. 
  • Interactions of human nucleotide excision repair protein XPA with DNA and RPA70 Delta C327: chemical shift mapping and 15N NMR relaxation studies. 
  • Inverted DNA repeats channel repair of distant double-strand breaks into chromatid fusions and chromosomal rearrangements. 
  • Ipr gene control of the anti-DNA antibody response. 
  • Kinetics of bisulfite-induced cytosine deamination in single-stranded DNA. 
  • Mechanisms of polyclonal B-cell activation in autoimmune B6-lpr/lpr mice. 
  • Microbial inactivation of Pseudomonas putida and Pichia pastoris using gene silencing. 
  • Molecular characterization of anti-DNA antibodies induced in normal mice by immunization with bacterial DNA. Differences from spontaneous anti-DNA in the content and location of VH CDR3 arginines. 
  • Mre11-Sae2 and RPA Collaborate to Prevent Palindromic Gene Amplification. 
  • Multiplex detection of disease biomarkers using SERS molecular sentinel-on-chip. 
  • Mutagenic processing of ribonucleotides in DNA by yeast topoisomerase I. 
  • Mutation of the p53 tumor-suppressor gene is not a feature of endometrial hyperplasias. 
  • Numerous group I introns with variable distributions in the ribosomal DNA of a lichen fungus. 
  • Optical characterizations and electronic devices of nearly pure (10,5) single-walled carbon nanotubes. 
  • Origin of overstretching transitions in single-stranded nucleic acids. 
  • Patterns of autoantibody expression in pediatric and adult systemic lupus erythematosus. 
  • Patterns of heavy and light chain utilization in the antibody response to single-stranded bacterial DNA in normal human subjects and patients with systemic lupus erythematosus. 
  • Photocontrolled micellar aggregation of amphiphilic DNA-azobenzene conjugates. 
  • Prediction of solvent-induced morphological changes of polyelectrolyte diblock copolymer micelles. 
  • Purification of the bacteriophage T4 type II DNA topoisomerase. 
  • RNA-DNA hybrid formation at a bacteriophage T4 replication origin. 
  • Recognition of single-stranded DNA by the bacteriophage T4-induced type II topoisomerase. 
  • Replication and preferential inheritance of hypersuppressive petite mitochondrial DNA. 
  • Role of Escherichia coli DNA polymerase I in conferring viability upon the dnaN159 mutant strain. 
  • S1-nuclease enhancement of the ethidium bromide binding assay of drug-induced DNA interstrand crosslinking in human brain tumor cells. 
  • Selective recognition of DNA antigenic determinants by murine monoclonal anti-DNA antibodies. 
  • Simian virus 40 (SV40) T antigen binds specifically to double-stranded DNA but not to single-stranded DNA or DNA/RNA hybrids containing the SV40 regulatory sequences. 
  • Single-stranded RNA facilitates nucleocapsid: APOBEC3G complex formation. 
  • Specificity analysis of antibodies to single-stranded micrococcal DNA in the sera of normal human subjects and patients with systemic lupus erythematosus. 
  • Specificity analysis of monoclonal anti-DNA antibodies from B6-lpr/lpr mice. 
  • Specificity and immunochemical properties of antibodies to bacterial DNA in sera of normal human subjects and patients with systemic lupus erythematosus (SLE). 
  • Specificity and immunochemical properties of antibodies to bacterial DNA. 
  • Specificity of anti-DNA antibodies induced in normal mice by immunization with bacterial DNA. 
  • Spectroscopic study of a DNA brush synthesized in situ by surface initiated enzymatic polymerization. 
  • Structural basis for the 3'-5' exonuclease activity of Escherichia coli DNA polymerase I: a two metal ion mechanism. 
  • Structure of DNA polymerase I Klenow fragment bound to duplex DNA. 
  • Surface-enhanced Raman scattering substrate based on a self-assembled monolayer for use in gene diagnostics. 
  • Surface-initiated enzymatic polymerization of DNA. 
  • Temporal correlation of antibody responses to different epitopes of the human La autoantigen. 
  • Tethering telomeric double- and single-stranded DNA-binding proteins inhibits telomere elongation. 
  • Tetramerization and single-stranded DNA binding properties of native and mutated forms of murine mitochondrial single-stranded DNA-binding proteins. 
  • The T4 phage SF1B helicase Dda is structurally optimized to perform DNA strand separation. 
  • The antibody response of normal mice to immunization with single-stranded DNA of various species origin. 
  • The binding of anti-DNA antibodies to phosphorothioate oligonucleotides in a solid phase immunoassay. 
  • The clearance of a monoclonal anti-DNA antibody following administration of DNA in normal and autoimmune mice. 
  • The fine specificity of monoclonal anti-DNA antibodies induced in normal mice by immunization with bacterial DNA. 
  • The influence of DNA size on the binding of anti-DNA antibodies in the solid and fluid phase. 
  • The influence of the lpr gene on B cell activation: differential antibody expression in lpr congenic mouse strains. 
  • The phage T4 protein UvsW drives Holliday junction branch migration. 
  • The role of Exo1p exonuclease in DNA end resection to generate gene conversion tracts in Saccharomyces cerevisiae. 
  • Transcription-associated mutagenesis. 
  • Transgene induced co-suppression during vegetative growth in Cryptococcus neoformans. 
  • Two-dimensional gel analysis of rolling circle replication in the presence and absence of bacteriophage T4 primase. 
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  Keywords of People

  • Berchuck, Andrew, James M. Ingram Professor of Gynecologic Oncology, Obstetrics and Gynecology, Gynecologic Oncology