Dopamine

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  Subject Areas on Research

  • "Model" behavior. 
  • "To learn, you must pay attention." Molecular insights into teachers' wisdom. 
  • (3H)norepinephrine binding and lipolysis by isolated fat cells. 
  • 3H-Dopamine uptake by synaptic storage vesicles of rat whole brain and brain regions. 
  • A Neural Circuit for Gut-Induced Reward. 
  • A fraction of the ventricular myocardium that has the specificity of the cardiac beta-adrenergic receptor. 
  • A genetically defined insula-brainstem circuit selectively controls motivational vigor. 
  • A major direct GABAergic pathway from zona incerta to neocortex. 
  • A mathematical model of circadian rhythms and dopamine. 
  • A mesocortical dopamine circuit enables the cultural transmission of vocal behaviour. 
  • A murine model of hyperdopaminergic state displays altered respiratory control. 
  • A rodent model of spontaneous stereotypy: initial characterization of developmental, environmental, and neurobiological factors. 
  • A thalamocorticostriatal dopamine network for psychostimulant-enhanced human cognitive flexibility. 
  • A tyrosine hydroxylase-yellow fluorescent protein knock-in reporter system labeling dopaminergic neurons reveals potential regulatory role for the first intron of the rodent tyrosine hydroxylase gene. 
  • ADHD and smoking: from genes to brain to behavior. 
  • ADHD, altered dopamine neurotransmission, and disrupted reinforcement processes: implications for smoking and nicotine dependence. 
  • Action, time and the basal ganglia. 
  • Activation in mesolimbic and visuospatial neural circuits elicited by smoking cues: evidence from functional magnetic resonance imaging. 
  • Activity patterns in mesolimbic regions in rats during operant tasks for reward. 
  • Acute and chronic nicotinic interactions with dopamine systems and working memory performance. 
  • Acute decompensated heart failure: update on new and emerging evidence and directions for future research. 
  • Adjunctive brexpiprazole for the treatment of major depressive disorder. 
  • Adolescent nicotine exposure produces immediate and long-term changes in CNS noradrenergic and dopaminergic function. 
  • Age-associated insolubility of parkin in human midbrain is linked to redox balance and sequestration of reactive dopamine metabolites. 
  • Age-related changes in brain catecholamine responses to a single footshock. 
  • Agonist binding promotes a guanine nucleotide reversible increase in the apparent size of the bovine anterior pituitary dopamine receptors. 
  • Alpha 1-adrenergic receptor-mediated downregulation of angiotensin II receptors in neuronal cultures. 
  • Alpha-adrenergic receptor identification by (3H)dihydroergocryptine binding. 
  • Alterations in central nervous system serotonergic and dopaminergic synaptic activity in adulthood after prenatal or neonatal chlorpyrifos exposure. 
  • Alterations in neurotransmitter activity after acute and chronic ethanol treatment: studies of transmitter interactions. 
  • Altered cocaine potency in the nucleus accumbens following 7-day withdrawal from intermittent but not continuous treatment: voltammetric assessment of dopamine uptake in the rat. 
  • Altered prefrontal dopaminergic function in chronic recreational ketamine users. 
  • Amitifadine, a triple reuptake inhibitor, reduces self-administration of the opiate remifentanil in rats. 
  • An Akt/beta-arrestin 2/PP2A signaling complex mediates dopaminergic neurotransmission and behavior. 
  • An animal model of attention deficit hyperactivity disorder. 
  • An involvement of dopamine in higher order choice mechanisms in the monkey. 
  • Androgen decreases dopamine neurone survival in rat midbrain. 
  • Anesthetic management of an AAI pacemaker patient with paroxysmal atrial fibrillation during colorectal surgery. 
  • Anterior pituitary hypoplasia and dwarfism in mice lacking the dopamine transporter. 
  • Antiproliferative action of dopamine and norepinephrine in neuroblastoma cells expressing the human dopamine transporter. 
  • Application of microdialysis and voltammetry to assess dopamine functions in genetically altered mice: correlation with locomotor activity. 
  • Attenuation of auditory startle and prepulse inhibition by unexpected changes in ambient illumination through dopaminergic mechanisms. 
  • Augmented methamphetamine-induced overflow of striatal dopamine 1 day after GDNF administration. 
  • Autoradiographic quantification of neurochemical markers of serotonin, dopamine and opioid systems in rat brain mesolimbic regions following chronic St John's wort treatment. 
  • Autoreceptor presynaptic control of dopamine release from striatum is lost at early stages of manganese poisoning. 
  • BDE99 (2,2',4,4',5-pentabromodiphenyl ether) suppresses differentiation into neurotransmitter phenotypes in PC12 cells. 
  • Behavioral and neurochemical consequences of ibotenic acid lesion in the subthalamic nucleus of the common marmoset. 
  • Behavioral and neurochemical effects of wild-type and mutated human alpha-synuclein in transgenic mice. 
  • Behavioral disturbances in adult mice following neonatal virus infection or kynurenine treatment--role of brain kynurenic acid. 
  • Beta cell monoamines: further evidence for their role in modulating insulin secretion. 
  • Binding of catecholamines to receptors in cultured myocardial cells. 
  • Biochemical and behavioral evaluation of pergolide as a dopamine agonist in the rat brain. 
  • Biological characterization of social phobia. 
  • Biomimetic anchors for antifouling and antibacterial polymer brushes on stainless steel 
  • Bone histomorphometric and biomechanical abnormalities in mice homozygous for deletion of the dopamine transporter gene. 
  • Brain catecholamines and memory modulation: effects of footshock, amygdala implantation, and stimulation. 
  • Brain neurotransmitter turnover rates during rat intravenous cocaine self-administration. 
  • Breast cancer patients have improved immune and neuroendocrine functions following massage therapy. 
  • Calcium-activated inward spike after-currents in bursting neurone R15 of Aplysia. 
  • Catecholamine synthesis is mediated by tyrosinase in the absence of tyrosine hydroxylase. 
  • Catecholaminergic cell lines from the brain and adrenal glands of tyrosine hydroxylase-SV40 T antigen transgenic mice. 
  • Catecholaminergic innervation of the hippocampus in the cynomolgus monkey. 
  • Catecholaminergic regulation of opiate-stimulated growth hormone secretion in the developing rat. 
  • Cellular determinants of reduced adaptability of the aging brain: neurotransmitter utilization and cell signaling responses after MDMA lesions. 
  • Cholinergic neurons constitutively engage the ISR for dopamine modulation and skill learning in mice. 
  • Cholinergic-dopaminergic interactions in cognitive performance. 
  • Cholinergic-dopaminergic interactions in radial-arm maze performance. 
  • Chronic cocaine administration increases CNS tyrosine hydroxylase enzyme activity and mRNA levels and tryptophan hydroxylase enzyme activity levels. 
  • Chronic cocaine administration sensitizes behavioral but not neuroendocrine responses. 
  • Clinical, 18F-dopa PET, and genetic analysis of an ethnic Chinese kindred with early-onset parkinsonism and parkin gene mutations. 
  • Cloning and functional characterization of a cocaine-sensitive dopamine transporter. 
  • Cloning, pharmacological characterization, and chromosome assignment of the human dopamine transporter. 
  • Cocaine acts on accumbens monoamines and locomotor behavior via a 5-HT2A/2C receptor mechanism as shown by ketanserin: 24-h follow-up studies. 
  • Cocaine and amphetamine elicit differential effects in rats with a unilateral injection of dopamine transporter antisense oligodeoxynucleotides. 
  • Cocaine increases dopamine release by mobilization of a synapsin-dependent reserve pool. 
  • Cocaine increases stimulated dopamine release more in periadolescent than adult rats. 
  • Cocaine inhibits central noradrenergic and dopaminergic activity during the critical developmental period in which catecholamines influence cell development. 
  • Cocaine self-administration in dopamine-transporter knockout mice. 
  • Combating Acute Heart Failure in the Arena: Lessons From the ROPA-DOP Trial. 
  • Combining 'caged-dopamine' photolysis with fast-scan cyclic voltammetry to assess dopamine clearance and release autoinhibition in vitro. 
  • Combining levodopa and virtual reality-based therapy for rehabilitation of the upper limb after acute stroke: pilot study Part II. 
  • Comparative antidopaminergic properties of thioridazine, mesoridazine and sulforidazine on the corpus striatum. 
  • Comparative dopamine-cholinergic mechanisms in the olfactory tubercle and the striatum: effects of metoclopramide. 
  • Concomitant development of [3H]-dopamine and [3H]-5-hydroxytryptamine uptake systems in rat brain regions. 
  • Concurrent autoreceptor-mediated control of dopamine release and uptake during neurotransmission: an in vivo voltammetric study. 
  • Conditional calcineurin knockout mice exhibit multiple abnormal behaviors related to schizophrenia. 
  • Contributions of hemodynamic monitoring to the treatment of chronic congestive heart failure. 
  • Contributions of neuroendocrine and local autocrine-paracrine mechanisms to the pathophysiology and pharmacology of congestive heart failure. 
  • Cooperativity between the phosphorylation of Thr95 and Ser77 of NHERF-1 in the hormonal regulation of renal phosphate transport. 
  • Coordination of Brain-Wide Activity Dynamics by Dopaminergic Neurons. 
  • Cortisol decreases and serotonin and dopamine increase following massage therapy. 
  • Creatine and cyclocreatine attenuate MPTP neurotoxicity. 
  • Critical prenatal and postnatal periods for persistent effects of dexamethasone on serotonergic and dopaminergic systems. 
  • D-amphetamine challenge effects on Wisconsin Card Sort Test. Performance in schizotypal personality disorder. 
  • D2 dopamine receptors in the human retina: cloning of cDNA and localization of mRNA. 
  • DDD mice, a novel acute mouse model of Parkinson's disease. 
  • Decreased spontaneous motor activity parallels reserpine-induced supersensitivity of catecholamine-responsive rat cerebral cortex adenylate cyclase. 
  • Delineation of discrete domains for substrate, cocaine, and tricyclic antidepressant interactions using chimeric dopamine-norepinephrine transporters. 
  • Depletion of brain amines reverses blood pressure response to footshock in rat. 
  • Desensitization of G protein-coupled receptors and neuronal functions. 
  • Designing Functionally Selective Noncatechol Dopamine D1 Receptor Agonists with Potent In Vivo Antiparkinsonian Activity. 
  • Development of alpha-noradrenergic and Dopaminergic receptor systems depends on maturation of their presynaptic nerve terminals in the rat brain. 
  • Development of dopamine neurotransmission and uptake inhibition in the caudate nucleus as measured by fast-cyclic voltammetry. 
  • Dietary manipulation of serotonergic and dopaminergic function in C57BL/6J mice with amino acid depletion mixtures. 
  • Differences in extracellular dopamine concentrations in the nucleus accumbens during response-dependent and response-independent cocaine administration in the rat. 
  • Differential Response to Low-Dose Dopamine or Low-Dose Nesiritide in Acute Heart Failure With Reduced or Preserved Ejection Fraction: Results From the ROSE AHF Trial (Renal Optimization Strategies Evaluation in Acute Heart Failure). 
  • Differential regulation of MeCP2 phosphorylation in the CNS by dopamine and serotonin. 
  • Differential regulation of dopamine D1A receptor responsiveness by various G protein-coupled receptor kinases. 
  • Differential regulation of tyrosine hydroxylase in the basal ganglia of mice lacking the dopamine transporter. 
  • Differential response of ventral midbrain and striatal progenitor cells to lesions of the nigrostriatal dopaminergic projection. 
  • Direct identification and characterisation of beta-adrenergic receptors in rat brain. 
  • Direct reprogramming of human fibroblasts into dopaminergic neuron-like cells. 
  • Diuretics and ultrafiltration in acute decompensated heart failure. 
  • Do sympathetic neurons coordinate cellular development in the heart and kidney? Effects of neonatal central and peripheral catecholaminergic lesions on cardiac and renal nucleic acids and proteins. 
  • Does dopamine contribute to striatal damage caused by impaired mitochondrial function? 
  • Dopamine D1 and D2 receptor antagonism during development alters later behavior in zebrafish. 
  • Dopamine Metabolism May Have Unexpected Benefits for Mitochondrial Energy Production. 
  • Dopamine and adaptive memory. 
  • Dopamine and dobutamine in septic shock. A comparison. 
  • Dopamine and α-synuclein dysfunction in Smad3 null mice. 
  • Dopamine attenuates evoked inhibitory synaptic currents in central amygdala neurons. 
  • Dopamine autoreceptor regulation of release and uptake in mouse brain slices in the absence of D(3) receptors. 
  • Dopamine efflux during withdrawal from continuous or intermittent cocaine. 
  • Dopamine enhances motor and neuropathological consequences of polyglutamine expanded huntingtin. 
  • Dopamine in amygdala gates limbic processing of aversive stimuli in humans. 
  • Dopamine inhibits burst-firing of neurosecretory cell R 15 in Aplysia californica: establishment of a dose-response relationship. 
  • Dopamine levels modulate the updating of tastant values. 
  • Dopamine mediates vagal modulation of the immune system by electroacupuncture. 
  • Dopamine modulates the response of the human amygdala: a study in Parkinson's disease. 
  • Dopamine neuronal transport kinetics and effects of amphetamine. 
  • Dopamine receptor of the porcine anterior pituitary gland. Evidence for two affinity states discriminated by both agonists and antagonists. 
  • Dopamine reduces slow outward current and calcium influx in burst-firing neuron R15 of Aplysia. 
  • Dopamine regulation of human speech and bird song: a critical review. 
  • Dopamine release and uptake are greater in female than male rat striatum as measured by fast cyclic voltammetry. 
  • Dopamine suppresses osteoclast differentiation via cAMP/PKA/CREB pathway. 
  • Dopamine tone regulates D1 receptor trafficking and delivery in striatal neurons in dopamine transporter-deficient mice. 
  • Dopamine transporter expression confers cytotoxicity to low doses of the parkinsonism-inducing neurotoxin 1-methyl-4-phenylpyridinium. 
  • Dopamine transporter is required for in vivo MPTP neurotoxicity: evidence from mice lacking the transporter. 
  • Dopamine transporter-dependent and -independent actions of trace amine beta-phenylethylamine. 
  • Dopamine transporters and neuronal injury. 
  • Dopamine uptake inhibitors but not dopamine releasers induce greater increases in motor behavior and extracellular dopamine in adolescent rats than in adult male rats. 
  • Dopamine-Dependent Sensitization of Rod Bipolar Cells by GABA Is Conveyed through Wide-Field Amacrine Cells. 
  • Dopamine-independent locomotor actions of amphetamines in a novel acute mouse model of Parkinson disease. 
  • Dopamine-modulated aversive emotion processing fails in alcohol-dependent patients. 
  • Dopamine-sensitive adenylate cyclase: antagonism by impiramine and its analogues. 
  • Dopamine: Context and counterfactuals. 
  • Dopamine: from pharmacology to molecular biology and back. 
  • Dopaminergic Control of Inflammation and Glycemia in Sepsis and Diabetes. 
  • Dopaminergic abnormalities in Hdac6-deficient mice. 
  • Dopaminergic behaviors and signal transduction mediated through adenylate cyclase and phospholipase C pathways. 
  • Dopaminergic control of corticostriatal long-term synaptic depression in medium spiny neurons is mediated by cholinergic interneurons. 
  • Dopaminergic inhibition of adenylate cyclase correlates with high affinity agonist binding to anterior pituitary D2 dopamine receptors. 
  • Dopaminergic modulation of retinal processing from starlight to sunlight. 
  • Dopaminergic neurodegeneration induced by Parkinson's disease-linked G2019S LRRK2 is dependent on kinase and GTPase activity. 
  • Dopaminergic supersensitivity in G protein-coupled receptor kinase 6-deficient mice. 
  • Dorsolateral prefrontal cortex drives mesolimbic dopaminergic regions to initiate motivated behavior. 
  • Dual control of dopamine synthesis and release by presynaptic and postsynaptic dopamine D2 receptors. 
  • Dysregulation of dopamine transporters via dopamine D2 autoreceptors triggers anomalous dopamine efflux associated with attention-deficit hyperactivity disorder. 
  • Effect of intrarenal administration of dopamine on renin release in conscious dogs. 
  • Effect of levodopa priming on dopamine neuron transplant efficacy and induction of abnormal involuntary movements in parkinsonian rats. 
  • Effect of photoperiod reversal on twenty-four hour patterns for dopamine levels in the corpus striatum and upper and lower brainstem of the rat. 
  • Effect of the monoamine oxidase inhibitors clorgyline and pargyline on the hyperphagia of obese mice. 
  • Effects of acute tryptophan depletion on brain serotonin function and concentrations of dopamine and norepinephrine in C57BL/6J and BALB/cJ mice. 
  • Effects of alpha-fluoromethylhistidine (FMH), an irreversible inhibitor of histidine decarboxylase, on development of brain histamine and catecholamine systems in the neonatal rat. 
  • Effects of low-dose dopamine on urine output in normotensive very low birth weight neonates. 
  • Effects of neonatal mercuric chloride administration on growth and biochemical development of neuronal and non-neuronal tissues in the rat: comparison with methylmercury. 
  • Effects of neurochemicals upon a dinoflagellate photoresponse. 
  • Effects of neuromodulation in a cortical network model of object working memory dominated by recurrent inhibition. 
  • Effects of neurotoxic doses of methamphetamine on potassium and amphetamine evoked overflow of dopamine in the striatum of awake rats. 
  • Effects of prenatal cocaine exposure on haloperidol-induced increases in prolactin release and dopamine turnover in weanling, periadolescent, and adult offspring. 
  • Electrochemiluminescence quenching as an indirect method for detection of dopamine and epinephrine with capillary electrophoresis. 
  • Electroconvulsive treatment and haloperidol: effects on pre- and postsynaptic dopamine receptors in rat brain. 
  • Elevation of cAMP is required for down-regulation, but not agonist-induced desensitization, of endogenous dopamine D1 receptors in opossum kidney cells. Studies in cells that stably express a rat cAMP phosphodiesterase (rPDE3) cDNA. 
  • Engineered D2R Variants Reveal the Balanced and Biased Contributions of G-Protein and β-Arrestin to Dopamine-Dependent Functions. 
  • Enhanced rewarding properties of morphine, but not cocaine, in beta(arrestin)-2 knock-out mice. 
  • Enhancement of dopaminergic properties and protection mediated by neuronal activation of Ras in mouse ventral mesencephalic neurones. 
  • Enhancing the efficiency of direct reprogramming of human primary fibroblasts into dopaminergic neuron-like cells through p53 suppression. 
  • Estimation of D2-like receptor occupancy by dopamine in the putamen of hemiparkinsonian Monkeys. 
  • Etiology of Parkinson's disease: Genetics and environment revisited. 
  • Evaluating dopamine reward pathway in ADHD: clinical implications. 
  • Evaluation of a sol-gel derived carbon composite electrode as an amperometric detector for capillary electrophoresis. 
  • Exercise activates vagal induction of dopamine and attenuates systemic inflammation. 
  • Exercise, Dopamine, and Cognition in Older Age. 
  • Exposure to methylmercury in utero: effects on biochemical development of catecholamine neurotransmitter systems. 
  • Exposure to mitochondrial genotoxins and dopaminergic neurodegeneration in Caenorhabditis elegans. 
  • Fe(III)-coordination properties of neuromelanin components: 5,6-dihydroxyindole and 5,6-dihydroxyindole-2-carboxylic acid. 
  • Fetal cocaine exposure causes persistent noradrenergic hyperactivity in rat brain regions: effects on neurotransmitter turnover and receptors. 
  • Fibroblasts that express aromatic amino acid decarboxylase have increased sensitivity to the synergistic cytotoxicity of L-dopa and manganese. 
  • Focal not widespread grafts induce novel dyskinetic behavior in parkinsonian rats. 
  • Food reward in the absence of taste receptor signaling. 
  • Functional hyperdopaminergia in dopamine transporter knock-out mice. 
  • Functional interaction between monoamine plasma membrane transporters and the synaptic PDZ domain-containing protein PICK1. 
  • Functional selectivity of dopamine receptor agonists. I. Selective activation of postsynaptic dopamine D2 receptors linked to adenylate cyclase. 
  • Functional selectivity of dopamine receptor agonists. II. Actions of dihydrexidine in D2L receptor-transfected MN9D cells and pituitary lactotrophs. 
  • GBR12909 stimulates hypothalamo-pituitary-adrenal activity by inhibition of uptake at hypothalamic dopamine neurons. 
  • GDNF protection against 6-OHDA-induced reductions in potassium-evoked overflow of striatal dopamine. 
  • GRK2-mediated inhibition of adrenergic and dopaminergic signaling in right ventricular hypertrophy: therapeutic implications in pulmonary hypertension. 
  • Gamma-butyrolactone sleep: A 24-hour rhythm paralleling normal sleep in the rat and CNS amine changes. 
  • Gene-gene interaction between FGF20 and MAOB in Parkinson disease. 
  • Genes implicated in serotonergic and dopaminergic functioning predict BMI categories. 
  • Genetic and genomic approaches to reward and addiction. 
  • Genetic variation in components of dopamine neurotransmission impacts ventral striatal reactivity associated with impulsivity. 
  • Genetic variation in dopamine neurotransmission and motor development of infants born extremely-low-birthweight. 
  • Glucocorticoids and the development of neuronal function: effects of prenatal dexamethasone exposure on central noradrenergic activity. 
  • Glucose Activates Vagal Control of Hyperglycemia and Inflammation in Fasted Mice. 
  • Glutamatergic modulation of hyperactivity in mice lacking the dopamine transporter. 
  • HMGB1 acts on microglia Mac1 to mediate chronic neuroinflammation that drives progressive neurodegeneration. 
  • Heroin neuroteratogenicity: delayed-onset deficits in catecholaminergic synaptic activity. 
  • High affinity agonist binding to the dopamine D3 receptor: chimeric receptors delineate a role for intracellular domains. 
  • High agonist-independent activity is a distinguishing feature of the dopamine D1B receptor subtype. 
  • High-frequency stimulation of the subthalamic nucleus reverses limb-use asymmetry in rats with unilateral 6-hydroxydopamine lesions. 
  • Higher levels of CSF homovanillic acid in recently abstinent cocaine-dependent patients. 
  • Hippocampus and Prefrontal Cortex Predict Distinct Timescales of Activation in the Human Ventral Tegmental Area. 
  • Histamine-, norepinephrine-, and dopamine-sensitive central adenylate cyclases: effects of chlorpromazine derivatives and butaclamol. 
  • History of Atrial Fibrillation and Trajectory of Decongestion in Acute Heart Failure. 
  • Homeostatic mechanisms in dopamine synthesis and release: a mathematical model. 
  • Hormonal gain control of a medial preoptic area social reward circuit. 
  • Hyperactivity and impaired response habituation in hyperdopaminergic mice. 
  • Hyperactivity, elevated dopaminergic transmission, and response to amphetamine in M1 muscarinic acetylcholine receptor-deficient mice. 
  • Hyperdopaminergia and NMDA receptor hypofunction disrupt neural phase signaling. 
  • Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter. 
  • Hypertension associated with alcohol withdrawal: assessment of mechanisms and complications. 
  • Identification of PSD-95 as a regulator of dopamine-mediated synaptic and behavioral plasticity. 
  • Images in neuroscience. A mouse knockout. 
  • Impaired development of central and peripheral catecholamine neurotransmitter systems in preweanling rats treated with alpha-difluoromethylornithine, a specific irreversible inhibitor of ornithine decarboxylase. 
  • Implanted reuptake-deficient or wild-type dopaminergic neurons improve ON L-dopa dyskinesias without OFF-dyskinesias in a rat model of Parkinson's disease. 
  • In search of a mechanism for receptor-mediated neurobehavioral teratogenesis by nicotine: catecholamine release by nicotine in immature rat brain regions. 
  • In vitro inhibition of collagen cross links by catechol analogs. 
  • Inactivation of the dopamine transporter reveals essential roles of dopamine in the control of locomotion, psychostimulant response, and pituitary function. 
  • Increased expression of the dopamine transporter leads to loss of dopamine neurons, oxidative stress and l-DOPA reversible motor deficits. 
  • Increased methamphetamine neurotoxicity in heterozygous vesicular monoamine transporter 2 knock-out mice. 
  • Increased renal dopamine and acute renal adaptation to a high-phosphate diet. 
  • Increased rewarding properties of morphine in dopamine-transporter knockout mice. 
  • Individual Differences in Dopamine Are Associated with Reward Discounting in Clinical Groups But Not in Healthy Adults. 
  • Individual differences in psychostimulant responses of female rats are associated with ovarian hormones and dopamine neuroanatomy. 
  • Inhibition of lysyl hydroxylase by catechol analogs. 
  • Initial nonfunction in cadaveric renal transplantation. 
  • Instrumental learning in hyperdopaminergic mice. 
  • Interactions of nigrostriate synaptic transmission, iontophoretic O-methylated phenethylamines, dopamine, apomorphine and acetylcholine. 
  • Intranigral administration of D2 dopamine receptor antisense oligodeoxynucleotides establishes a role for nigrostriatal D2 autoreceptors in the motor actions of cocaine. 
  • Intravascular food reward. 
  • Iodine 131-labeled metaiodobenzylguanidine scintigraphy and biochemical analyses in suspected pheochromocytoma. 
  • Iron deficiency anemia and increased urinary norepinephrine excretion. 
  • Knockout of the vesicular monoamine transporter 2 gene results in neonatal death and supersensitivity to cocaine and amphetamine. 
  • L-DOPA is an endogenous ligand for OA1. 
  • L-dopa challenge and relapse in schizophrenia. 
  • Lack of consistent sex differences in D-amphetamine-induced dopamine release measured with [¹⁸ F]fallypride PET. 
  • Lack of potency of metoclopramide's metabolites in various dopaminergic models. 
  • Lithium antagonizes dopamine-dependent behaviors mediated by an AKT/glycogen synthase kinase 3 signaling cascade. 
  • Loss of autoreceptor functions in mice lacking the dopamine transporter. 
  • Low-dose dopamine or low-dose nesiritide in acute heart failure with renal dysfunction: the ROSE acute heart failure randomized trial. 
  • MDMA "ecstasy" alters hyperactive and perseverative behaviors in dopamine transporter knockout mice. 
  • Magnetic resonance imaging at microscopic resolution reveals subtle morphological changes in a mouse model of dopaminergic hyperfunction. 
  • Mechanisms of amphetamine action revealed in mice lacking the dopamine transporter. 
  • Methamphetamine toxicity is attenuated in mice that overexpress human manganese superoxide dismutase. 
  • Methylphenidate-elicited dopamine increases in ventral striatum are associated with long-term symptom improvement in adults with attention deficit hyperactivity disorder. 
  • Mice lacking the dopamine transporter display altered regulation of distal colonic motility. 
  • Mice lacking the norepinephrine transporter are supersensitive to psychostimulants. 
  • Microglial dopamine receptor elimination defines sex-specific nucleus accumbens development and social behavior in adolescent rats. 
  • Mimicking maternal smoking and pharmacotherapy of preterm labor: interactions of fetal nicotine and dexamethasone on serotonin and dopamine synaptic function in adolescence and adulthood. 
  • Models of dopaminergic and serotonergic signaling. 
  • Modulating role of lithium on dopamine turnover, prolactin release, and behavioral supersensitivity following haloperidol and reserpine. 
  • Molecular characterization of the dopamine transporter. 
  • Monoamine mediation of cocaine-induced hypothalamo-pituitary-adrenal activation. 
  • Monoamine oxidase and catechol-O-methyltransferase activity in hamster and rat insulinomas. 
  • Monoaminergic dysregulation in glutathione-deficient mice: possible relevance to schizophrenia? 
  • Motivation deficit in ADHD is associated with dysfunction of the dopamine reward pathway. 
  • Multilocus genetic profile for dopamine signaling predicts ventral striatum reactivity. 
  • Natural killer cells and lymphocytes increase in women with breast cancer following massage therapy. 
  • Neonatal 6-hydroxydopamine lesions of the frontal cortex in rats: persisting effects on locomotor activity, learning and nicotine self-administration. 
  • Neonatal chlorpyrifos exposure alters synaptic development and neuronal activity in cholinergic and catecholaminergic pathways. 
  • Neonatal methylmercury poisoning in the rat: effects on development of central catecholamine neurotransmitter systems. 
  • Neonatal parathion exposure disrupts serotonin and dopamine synaptic function in rat brain regions: modulation by a high-fat diet in adulthood. 
  • Neuro-Immune Mechanisms Regulating Social Behavior: Dopamine as Mediator? 
  • Neurobehavioral effects of 1,2-propanediol in zebrafish (Danio rerio). 
  • Neurocognitive correlates of the COMT Val(158)Met polymorphism in chronic schizophrenia. 
  • Neurological disturbances, nigrostriate synapses, and iontophoretic dopamine and apomorphine after haloperidol. 
  • Neuronal cell death in Huntington's disease: a potential role for dopamine. 
  • Neuronal localization of the enhanced adenylate cyclase responsiveness to catecholamines in the rat cerebral cortex following reserpine injections. 
  • Neuropsychological correlates of central monoamine function in chronic schizophrenia: relationship between CSF metabolites and cognitive function. 
  • Neurotensin interacts with dopaminergic neurons in rat brain. 
  • Neurotensin-induced dopamine release in vivo and in vitro from substantia nigra and nucleus caudate. 
  • Neurotransmitter Imbalance in the Brain and Alzheimer's Disease Pathology. 
  • New double-lumen polyethylene cannula for push-pull perfusion of brain tissue in vivo. 
  • Nicotine effects on learning in zebrafish: the role of dopaminergic systems. 
  • Nicotine interactions with haloperidol, clozapine and risperidone and working memory function in rats. 
  • Norepinephrine transporter-deficient mice exhibit excessive tachycardia and elevated blood pressure with wakefulness and activity. 
  • Novel roles for β-arrestins in the regulation of pharmacological sequestration to predict agonist-induced desensitization of dopamine D3 receptors. 
  • Obligatory role of thyroid hormones in development of peripheral sympathetic and central nervous system catecholaminergic neurons: effects of propylthiouracil-induced hypothyroidism on transmitter levels, turnover and release. 
  • Oestrogen receptors enhance dopamine neurone survival in rat midbrain. 
  • Ophthalmology issues in schizophrenia. 
  • Overexpression of VMAT-2 and DT-diaphorase protects substantia nigra-derived cells against aminochrome neurotoxicity. 
  • PGC-1α, a potential therapeutic target for early intervention in Parkinson's disease. 
  • Partial-volume correction increases estimated dopamine D2-like receptor binding potential and reduces adult age differences. 
  • Patterning small-molecule biocapture surfaces: microcontact insertion printing vs. photolithography. 
  • Perinatal dietary supplementation with a soy lecithin preparation: effects on development of central catecholaminergic neurotransmitter systems. 
  • Perinatal exposure to environmental tobacco smoke upregulates nicotinic cholinergic receptors in monkey brain. 
  • Peripheral chemoreflex inhibition with low-dose dopamine: new insight into mechanisms of extreme apnea. 
  • Persistent hyperdopaminergia decreases the peak frequency of hippocampal theta oscillations during quiet waking and REM sleep. 
  • Pharmacologic evaluation of dopaminergic receptor blockade by metoclopramide. 
  • Plasma homovanillic acid and performance on motor and cognitive tasks in community-dwelling elderly: MacArthur studies of successful aging. 
  • Plasma membrane transporters of serotonin, dopamine, and norepinephrine mediate serotonin accumulation in atypical locations in the developing brain of monoamine oxidase A knock-outs. 
  • Postsynaptic Mechanisms Render Syn I/II/III Mice Highly Responsive to Psychostimulants. 
  • Predictors of inotrope use during separation from cardiopulmonary bypass. 
  • Pregnancy anxiety and comorbid depression and anger: effects on the fetus and neonate. 
  • Prenatal chlorpyrifos exposure elicits presynaptic serotonergic and dopaminergic hyperactivity at adolescence: critical periods for regional and sex-selective effects. 
  • Prenatal dopamine and neonatal behavior and biochemistry. 
  • Presynaptic inhibition of dopamine synthesis in rat striatum: effects of chronic dopamine depletion and receptor blockade. 
  • Presynaptic input regulates development of beta-adrenergic control of rat brain ornithine decarboxylase: effects of 6-hydroxydopamine or propranolol. 
  • Presynaptic nicotinic cholinergic receptors labeled by [3H]acetylcholine on catecholamine and serotonin axons in brain. 
  • Profound neuronal plasticity in response to inactivation of the dopamine transporter. 
  • Prolonged inhibition in burst firing neurons: synaptic inactivation of the slow regenerative inward current. 
  • Psychopharmacological investigations of a lead-induced long-term cognitive deficit in monkeys. 
  • Quantitative 1H magnetic resonance spectroscopic imaging determines therapeutic immunization efficacy in an animal model of Parkinson's disease. 
  • Radioenzymatic assay of platelet serotonin, dopamine and norepinephrine in subjects with normal and increased serotonin production. 
  • Randomized Evaluation of Heart Failure With Preserved Ejection Fraction Patients With Acute Heart Failure and Dopamine: The ROPA-DOP Trial. 
  • Rapid alterations in corticostriatal ensemble coordination during acute dopamine-dependent motor dysfunction. 
  • Re-evaluation of the role of the dopamine transporter in dopamine system homeostasis. 
  • Receptor, Ligand and Transducer Contributions to Dopamine D2 Receptor Functional Selectivity. 
  • Recovery of presynaptic dopaminergic functioning in rats treated with neurotoxic doses of methamphetamine. 
  • Reduced blue cone electroretinogram in cocaine-withdrawn patients. 
  • Reduced dopamine receptors and transporters but not synthesis capacity in normal aging adults: a meta-analysis. 
  • Regional brain catecholamines and memory: effects of footshock, amygdala implantation, and stimulation. 
  • Regional metabolic changes in the pedunculopontine nucleus of unilateral 6-hydroxydopamine Parkinson's model rats. 
  • Regulation of complex I by Engrailed is complex too. 
  • Regulation of responsiveness at D2 dopamine receptors by receptor desensitization and adenylyl cyclase sensitization. 
  • Regulatory T cells attenuate Th17 cell-mediated nigrostriatal dopaminergic neurodegeneration in a model of Parkinson's disease. 
  • Relation between reversal of diastolic creep and recovery of systolic function after ischemic myocardial injury in conscious dogs. 
  • Renal and circulatory mechanisms in congestive heart failure. 
  • Reply: Diuretic Strategies and Renal Dysfunction in Heart Failure With Preserved Ejection Fraction. 
  • Reserpine-induced up-regulation of dopamine D2 receptors in the rat striatum is enhanced by denervation but not by chronic receptor blockade. 
  • Restorative effects of GDNF on striatal dopamine release in rats treated with neurotoxic doses of methamphetamine. 
  • Retinomotor movements in isolated teleost retinal cone inner-outer segment preparations (CIS-COS): effects of light, dark and dopamine. 
  • Reversal of cocaine-induced behavioral sensitization and associated phosphorylation of the NR2B and GluR1 subunits of the NMDA and AMPA receptors. 
  • Reward-guided learning beyond dopamine in the nucleus accumbens: the integrative functions of cortico-basal ganglia networks. 
  • Reward-motivated learning: mesolimbic activation precedes memory formation. 
  • Right frontal EEG and pregnancy/neonatal outcomes. 
  • Rod vision is controlled by dopamine-dependent sensitization of rod bipolar cells by GABA. 
  • Role of carotid body catecholamines in chemoreceptor function. 
  • Role of dopamine transporter in methamphetamine-induced neurotoxicity: evidence from mice lacking the transporter. 
  • Role of neurotransmitters in seizure mechanisms in the kindling model of epilepsy. 
  • Role of nicotinic receptors in the lateral habenula in the attenuation of amphetamine-induced prepulse inhibition deficits of the acoustic startle response in rats. 
  • Role of serotonin in the paradoxical calming effect of psychostimulants on hyperactivity. 
  • Role of the midbrain dopaminergic system in modulation of vocal brain activation by social context. 
  • Selective activation of mesoamygdaloid dopamine neurons by conditioned stress: attenuation by diazepam. 
  • Selective deletion of GRK2 alters psychostimulant-induced behaviors and dopamine neurotransmission. 
  • Septohippocampal cholinergic changes after destruction of the A10-septal dopaminergic pathways. 
  • Sex differences in neurochemical effects of dopaminergic drugs in rat striatum. 
  • Sex, ADHD symptoms, and smoking outcomes: an integrative model. 
  • Signaling pathways utilized by PTH and dopamine to inhibit phosphate transport in mouse renal proximal tubule cells. 
  • Silencing of the constitutive activity of the dopamine D1B receptor. Reciprocal mutations between D1 receptor subtypes delineate residues underlying activation properties. 
  • Silver exposure in developing zebrafish produces persistent synaptic and behavioral changes. 
  • Silver impairs neurodevelopment: studies in PC12 cells. 
  • Single-cell redox imaging demonstrates a distinctive response of dopaminergic neurons to oxidative insults. 
  • Social context-dependent singing-regulated dopamine. 
  • Sodium-hydrogen exchanger regulatory factor 1 (NHERF-1) transduces signals that mediate dopamine inhibition of sodium-phosphate co-transport in mouse kidney. 
  • Spike aftercurrents in R15 of Aplysia: their relationship to slow inward current and calcium influx. 
  • Spinal cord stimulation restores locomotion in animal models of Parkinson's disease. 
  • Spine pruning drives antipsychotic-sensitive locomotion via circuit control of striatal dopamine. 
  • Strengths and limitations of morphological and behavioral analyses in detecting dopaminergic deficiency in Caenorhabditis elegans. 
  • Stress selectively increases fos protein in dopamine neurons innervating the prefrontal cortex. 
  • Studies of dopamine pharmacology in molluscs. 
  • Succinylated octopamine ascarosides and a new pathway of biogenic amine metabolism in Caenorhabditis elegans. 
  • Sustained elevation of extracellular dopamine causes motor dysfunction and selective degeneration of striatal GABAergic neurons. 
  • Synapsins differentially control dopamine and serotonin release. 
  • Synaptic development in brains of rats exposed perinatally to ethanol. 
  • Synaptic mechanism of pentylenetetrazole: selectivity for chloride conductance. 
  • Synthesis and dopamine agonist properties of (+-)-trans-3,4,4a,10b-tetrahydro-4-propyl-2H,5H-[1]benzopyrano [4,3-b]-1,4-oxazin-9-ol and its enantiomers. 
  • Synthesis and pharmacological evaluation of 1-phenyl-3-amino-1,2,3,4-tetrahydronaphthalenes as ligands for a novel receptor with sigma-like neuromodulatory activity. 
  • Systematic errors in detecting biased agonism: Analysis of current methods and development of a new model-free approach. 
  • TAAR1 activation modulates monoaminergic neurotransmission, preventing hyperdopaminergic and hypoglutamatergic activity. 
  • TBR-760, a Dopamine-Somatostatin Compound, Arrests Growth of Aggressive Nonfunctioning Pituitary Adenomas in Mice. 
  • Tactile-kinesthetic stimulation effects on sympathetic and adrenocortical function in preterm infants. 
  • Targeted deletion of GD3 synthase protects against MPTP-induced neurodegeneration. 
  • Targeting the kidney in acute heart failure: can old drugs provide new benefit? Renal Optimization Strategies Evaluation in Acute Heart Failure (ROSE AHF) trial. 
  • Targeting β-arrestin2 in the treatment of L-DOPA-induced dyskinesia in Parkinson's disease. 
  • Tetrabenazine, an amine-depleting drug, also blocks dopamine receptors in rat brain. 
  • The Akt-GSK-3 signaling cascade in the actions of dopamine. 
  • The Dose Makes the Poison: Comparing Epinephrine With Dopamine in Pediatric Septic Shock. 
  • The dopamine metabolite 3-methoxytyramine is a neuromodulator. 
  • The dopamine transporter. The cloned target site of parkinsonism-inducing toxins and of drugs of abuse. 
  • The dopamine transporter: a crucial component regulating dopamine transmission. 
  • The effect of phencyclidine on dopamine metabolism in the mouse brain. 
  • The effect of tremorine on dopamine concentration in the brain of the rat, guinea pig and rabbit. 
  • The effects of dopamine on myocardial functional recovery after reversible ischemic injury. 
  • The emergence of gonadal hormone influences on dopaminergic function during puberty. 
  • The fat mass and obesity associated gene (Fto) regulates activity of the dopaminergic midbrain circuitry. 
  • The influence of time on the response to dopamine after coronary artery bypass grafting: assessment of left ventricular performance and contractility using pressure/dimension analyses. 
  • The involvement of the dopaminergic midbrain and cortico-striatal-thalamic circuits in the integration of reward prospect and attentional task demands. 
  • The kidney and hypertension: novel insights from transgenic models. 
  • The multiple LIM domain-containing adaptor protein Hic-5 synaptically colocalizes and interacts with the dopamine transporter. 
  • The selective serotonin reuptake inhibitor citalopram induces the storage of serotonin in catecholaminergic terminals. 
  • The sources of the nigrotectal pathway. 
  • The subchronic effects of the TRH analog TA-0910 and bromocriptine on alcohol preference in alcohol-preferring rats: development of tolerance and cross-tolerance. 
  • The vasodilatory effects of hydralazine, nicardipine, nitroglycerin, and fenoldopam in the human umbilical artery. 
  • Therapeutic immunization protects dopaminergic neurons in a mouse model of Parkinson's disease. 
  • Therapy of malignant hamster insulinomas with monoamine precursors. 
  • Time-dependent recovery from the effects of 6-hydroxydopamine lesions of the rat nucleus accumbens on cocaine self-administration and the levels of dopamine in microdialysates. 
  • Trace amine associated receptor 1 and movement control. 
  • Transcriptional profiles reveal similarities and differences in the effects of developmental neurotoxicants on differentiation into neurotransmitter phenotypes in PC12 cells. 
  • Treating shock--old drugs, new ideas. 
  • Uptake of (-) 3H-norepinephrine by storage vesicles prepared from whole rat brain: properties of the uptake system and its inhibition by drugs. 
  • Variability in nucleus accumbens activity mediates age-related suboptimal financial risk taking. 
  • Vasoactive medications in extremely low gestational age neonates during the first postnatal week. 
  • Ventral hippocampal dopamine D1 and D2 systems and spatial working memory in rats. 
  • Voltammetric evidence for discrete serotonin circuits, linked to specific reuptake domains, in the mouse medial prefrontal cortex. 
  • Withdrawal from continuous or intermittent cocaine administration: changes in D2 receptor function. 
  • Zebrafish provide a sensitive model of persisting neurobehavioral effects of developmental chlorpyrifos exposure: comparison with nicotine and pilocarpine effects and relationship to dopamine deficits. 
  • [3H]dihydroergocryptine binding in rat brain. 
  • [Behavioral, cellular and molecular consequences of the dopamine transporter gene inactivation]. 
  • [Problem of neuronal reception and the dopamine hypothesis of schizophrenia]. 
  • α-Synuclein fibril-induced inclusion spread in rats and mice correlates with dopaminergic Neurodegeneration. 
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  Keywords of People

  • Calakos, Nicole, Lincoln Financial Group Distinguished Professor of Neurobiology, Duke Science & Society
  • Dickerson, Kathryn C, Assistant Professor in Psychiatry and Behavioral Sciences, Center for Cognitive Neuroscience
  • Huettel, Scott, Professor in the Department of Psychology and Neuroscience, Duke Science & Society
  • Nicolelis, Miguel Angelo L., Duke School of Medicine Professor in Neuroscience, Neurobiology
  • Rada Rincon, Pedro Vicente, Senior Lecturer in Neuroscience at Duke Kunshan University, DKU Faculty
  • Samanez-Larkin, Gregory Russell, Jack H. Neely Associate Professor, Center for Cognitive Neuroscience