Dose-Response Relationship, Immunologic
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Subject Areas on Research
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A comparative evaluation of nasal and parenteral vaccine adjuvants to elicit systemic and mucosal HIV-1 peptide-specific humoral immune responses in cynomolgus macaques.
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A consensus protocol for the determination of the threshold doses for allergenic foods: how much is too much?
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A dose-ranging study of a prototype synthetic HIV-1MN V3 branched peptide vaccine. The National Institute of Allergy and Infectious Diseases AIDS Vaccine Evaluation Group.
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Activation of human B lymphocytes. III. Concanavalin A-induced generation of suppressor cells of the plaque-forming cell response of normal human B lymphocytes.
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Activator-bound C1 is less susceptible to inactivation by C1 inhibition than is fluid-phase C1.
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Active specific immunotherapy of Dukes B2 and C colorectal carcinoma: comparison of two doses of the vaccine.
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Alterations in antibody-dependent cellular cytotoxicity during the course of HIV-1 infection. Humoral and cellular defects.
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Anti-amyloid therapy protects against retinal pigmented epithelium damage and vision loss in a model of age-related macular degeneration.
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Anti-mouse mesangial cell serum induces acute glomerulonephropathy in mice.
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Anti-receptor antibody-induced H-Y-specific delayed-type hypersensitivity responses in nonresponder mice.
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Antibodies against the CD44 p80, lymphocyte homing receptor molecule augment human peripheral blood T cell activation.
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Antibodies reactive with class II antigens encoded for by the major histocompatibility complex inhibit human B cell activation.
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Antibody isotype-specific engagement of Fcgamma receptors regulates B lymphocyte depletion during CD20 immunotherapy.
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B lymphocytes differentially influence acute and chronic allograft rejection in mice.
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Bacterial infection of osteoblasts induces interleukin-1beta and interleukin-18 transcription but not protein synthesis.
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CAMPATH-1H in rheumatoid arthritis--an intravenous dose-ranging study.
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CD4+Thy1- thymocytes with a Th-type 2 cytokine response.
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Characterization and affinity isolation of xenoreactive human natural antibodies.
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Characterization of human chemotactic lymphokine production induced by mitogens and mixed leukocyte reactions using a new microassay.
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Cholera toxin acts as a potent adjuvant for the induction of cytotoxic T-lymphocyte responses with non-replicating antigens.
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Comparison of multiple vaccine vectors in a single heterologous prime-boost trial.
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Control of idiotope expression by monoclonal anti-idiotope and idiotope-bearing antibody.
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Corneal organ cultures in tyrosinemia release chemotactic factors.
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Depression, urinary free cortisol excretion and lymphocyte function.
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Distinct dendritic cell populations sequentially present antigen to CD4 T cells and stimulate different aspects of cell-mediated immunity.
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Dose-Dependent Infectivity of Aseptic, Purified, Cryopreserved Plasmodium falciparum 7G8 Sporozoites in Malaria-Naive Adults.
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Early low-titer neutralizing antibodies impede HIV-1 replication and select for virus escape.
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Effectiveness of measles vaccination and vitamin A treatment.
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Effects of dose and duration of anti-CD154 antibody therapy in preventing renal allograft rejection in a nonhuman primate model.
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Five new epitope-defined monoclonal antibodies reactive with GM2 and human glioma and medulloblastoma cell lines.
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Fluconazole dosing for the prevention or treatment of invasive candidiasis in young infants.
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Genetic control of peripheral leukocyte response to endotoxin in mice.
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Genetic control of the immune response to staphylococcal nuclease. VII. Role of non-H2-linked genes in the control of the anti-nuclease antibody response.
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High doses of intravenous Ig inhibit in vitro uptake of C4 fragments onto sensitized erythrocytes.
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High-dose intravenous immunoglobulin modifies complement-mediated in vivo clearance.
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Histone deacetylation critically determines T cell subset radiosensitivity.
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Human immunodeficiency virus type 1 (HIV-1) gp120-specific antibodies in neonates receiving an HIV-1 recombinant gp120 vaccine.
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Human plasmacytoid dendritic cells activated by CpG oligodeoxynucleotides induce the generation of CD4+CD25+ regulatory T cells.
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Human xenograft-nude mouse model of adoptive immunotherapy with human melanoma-specific cytotoxic T-cells.
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Humoral immune responses in Cr2-/- mice: enhanced affinity maturation but impaired antibody persistence.
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Hyaluronan fragments contribute to the ozone-primed immune response to lipopolysaccharide.
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ICAM-1 (CD54) expression on B lymphocytes is associated with their costimulatory function and can be increased by coactivation with IL-1 and IL-7.
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Identification of transforming growth factor-beta as an immunosuppressive factor in aqueous humor.
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Immunization of normal human splenocytes in vitro to produce human monoclonal antibodies to cellular antigens.
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Immunoglobulin prevents complement-mediated hyperacute rejection in swine-to-primate xenotransplantation.
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Impaired lymphocyte function in depressive illness.
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In vitro assay for curative activity in blood of mice infected with Trypanosoma musculi.
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Individualization of gamma globulin dosage in patients with humoral immunodeficiency.
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Induction of protective CTL responses in newborn mice by a murine retrovirus.
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Infection with Mycobacterium bovis BCG diverts traffic of myelin oligodendroglial glycoprotein autoantigen-specific T cells away from the central nervous system and ameliorates experimental autoimmune encephalomyelitis.
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Influence of HIV-1 infection and cigarette smoking on leukocyte profiles in homosexual men. The Multicenter AIDS Cohort Study.
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Inhibition of in vitro NZB antibody responses by cyclosporine.
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Inhibition of the growth of human melanoma metastases in nude mice by melanoma-specific murine monoclonal antibody.
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Ir genes of different high responder haplotypes for staphylococcal nuclease are not allelic.
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Kinetics of TCR use in response to repeated epitope-specific immunization.
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Ligation of cell surface-associated glucose-regulated protein 78 by receptor-recognized forms of alpha 2-macroglobulin: activation of p21-activated protein kinase-2-dependent signaling in murine peritoneal macrophages.
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Lipopolysaccharide prevents apoptosis and induces responsiveness to antigen receptor cross-linking in immature B cells.
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Lymphocyte responses to purified ragweed allergens in vitro. I. Proliferative responses in normal, newborn, agammaglobulinemic, and atopic subjects.
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Lymphocyte responses to ragweed antigens from different sources.
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Mapping of a ligand-binding site for the human thromboxane A2 receptor protein.
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Methacholine-induced cutaneous flare response: bivariate analysis of responsiveness and sensitivity.
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Modulation of FcR function by complement: subcomponent C1q enhances the phagocytosis of IgG-opsonized targets by human monocytes and culture-derived macrophages.
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Modulation of immunologic responses to HIV-1MN recombinant gp160 vaccine by dose and schedule of administration. National Institute of Allergy and Infectious Diseases AIDS Vaccine Evaluation Group.
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Modulation of lymphocyte functions by group A streptococcal membrane.
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Monoclonal antibodies directed against gonococcal protein I vary in bactericidal activity.
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Neutralizing antibodies to HIV-1 in seronegative volunteers immunized with recombinant gp120 from the MN strain of HIV-1. NIAID AIDS Vaccine Clinical Trials Network.
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Osteopontin is a negative feedback regulator of nitric oxide synthesis in murine macrophages.
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Pharmacokinetics of a new 10% intravenous immunoglobulin in patients receiving replacement therapy for primary immunodeficiency.
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Phase 1 clinical trials of the National Institutes of Health Vaccine Research Center HIV/AIDS candidate vaccines.
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Phase 1/2 multiple ascending dose trial of the prostate-specific membrane antigen-targeted antibody drug conjugate MLN2704 in metastatic castration-resistant prostate cancer.
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Phase I/II trial of intermittent subcutaneous IL-2 administration in pediatric patients with moderate immune suppression: results of Pediatric AIDS Clinical Trials Study 402.
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Potent and broad neutralizing activity of a single chain antibody fragment against cell-free and cell-associated HIV-1.
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Radiolocalization of human pancreatic tumors in athymic mice by monoclonal antibody DU-PAN 1.
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Regulation of complement activity by vaccinia virus complement-control protein.
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Role of CD95/Fas and its ligand in the regulation of the growth of human CD34(++)CD38(-) fetal liver cells.
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SMAD4 is required for development of maximal endotoxin tolerance.
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Safety and Immunogenicity of a Single Low Dose or High Dose of Clade 2 Influenza A(H5N1) Inactivated Vaccine in Adults Previously Primed With Clade 1 Influenza A(H5N1) Vaccine.
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Safety and immunogenicity of 2009 pandemic H1N1 influenza vaccination in perinatally HIV-1-infected children, adolescents, and young adults.
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Safety and immunogenicity of Env 2-3, a human immunodeficiency virus type 1 candidate vaccine, in combination with a novel adjuvant, MTP-PE/MF59. NIAID AIDS Vaccine Evaluation Group.
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Safety and immunogenicity of an inactivated influenza A/H5N1 vaccine given with or without aluminum hydroxide to healthy adults: results of a phase I-II randomized clinical trial.
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Safety and immunogenicity of one vs. two injections of Oka/Merck varicella vaccine in healthy children.
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Specificity of human bactericidal antibodies against PorA P1.7,16 induced with a hexavalent meningococcal outer membrane vesicle vaccine.
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Split tolerance permits safe Ad5-GUCY2C-PADRE vaccine-induced T-cell responses in colon cancer patients.
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Studies of high doses of a human immunodeficiency virus type 1 recombinant glycoprotein 160 candidate vaccine in HIV type 1-seronegative humans. The AIDS Vaccine Clinical Trials Network.
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Surfactant protein A regulates complement activation.
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TGF-beta inhibits the in vitro induction of lymphokine-activated killing activity.
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The biological activity of a liposomal complete core lipopolysaccharide vaccine.
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The cytotoxicity and microdosimetry of astatine-211-labeled chimeric monoclonal antibodies in human glioma and melanoma cells in vitro.
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The induction of tolerance and suppression in autoimmune MRL mice using hapten-modified self.
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The requirement of reversible cysteine sulfenic acid formation for T cell activation and function.
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The role of complement in the induction of antibody responses.
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The role of leukotriene B4 in Clostridium difficile toxin A-induced ileitis in rats.
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Tumor membrane lymphocyte stimulation assay in patients with renal cell carcinoma.
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Use of a new chemically modified intravenous IgG preparation in severe primary humoral immunodeficiency: clinical efficacy and attempts to individualize dosage.
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Variation in DNA and RNA synthetic responses during activation of lymphocytes from inbred strains of mice.
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Keywords of People
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Bowes Rickman, Catherine,
Professor of Ophthalmology,
Cell Biology
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Farsiu, Sina,
Paul Ruffin Scarborough Distinguished Associate Professor of Engineering,
Electrical and Computer Engineering
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Weinhold, Kent James,
Joseph W. and Dorothy W. Beard Distinguished Professor of Experimental Surgery, in the School of Medicine,
Immunology