Drosophila melanogaster

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  Subject Areas on Research

  • A Functionally Conserved Gene Regulatory Network Module Governing Olfactory Neuron Diversity. 
  • A GH3-like domain in reaper is required for mitochondrial localization and induction of IAP degradation. 
  • A New Resource for Characterizing X-linked Genes in Drosophila melanogaster: Systematic Coverage and Subdivision of the X Chromosome with Nested, Y-linked Duplications. 
  • A bidirectional kinesin motor in live Drosophila embryos. 
  • A chimeric kinesin-1 head/kinesin-5 tail motor switches between diffusive and processive motility. 
  • A cis-regulatory map of the Drosophila genome. 
  • A conserved family of cellular genes related to the baculovirus iap gene and encoding apoptosis inhibitors. 
  • A contractile actomyosin network linked to adherens junctions by Canoe/afadin helps drive convergent extension. 
  • A deletion-generator compound element allows deletion saturation analysis for genomewide phenotypic annotation. 
  • A developmental biologist's "outside-the-cell" thinking. 
  • A functional division of Drosophila sweet taste neurons that is value-based and task-specific. 
  • A genome-wide RNAi screen reveals multiple regulators of caspase activation. 
  • A guide for performing germ cell mutagenesis assays using Drosophila melanogaster. 
  • A kinesin motor in a force-producing conformation. 
  • A kingpin of academic inclusive fitness: the history and contributions of Bruce Grant. 
  • A kinome RNAi screen identified AMPK as promoting poxvirus entry through the control of actin dynamics. 
  • A method to measure myocardial calcium handling in adult Drosophila. 
  • A microtubule-destabilizing kinesin motor regulates spindle length and anchoring in oocytes. 
  • A molecular basis for inositol polyphosphate synthesis in Drosophila melanogaster. 
  • A multimember kinesin gene family in Drosophila. 
  • A mutation in the largest subunit of RNA polymerase II alters RNA chain elongation in vitro. 
  • A neuropeptidergic circuit gates selective escape behavior of Drosophila larvae. 
  • A new trick for Cyclin-Cdk: activation of STAT. 
  • A non-canonical start codon in the Drosophila fragile X gene yields two functional isoforms. 
  • A paired-end sequencing strategy to map the complex landscape of transcription initiation. 
  • A recombinational portrait of the Drosophila pseudoobscura genome. 
  • A systematic analysis of microtubule-destabilizing factors during dendrite pruning in Drosophila. 
  • A tripartite interaction among alleles of Notch, Delta, and Enhancer of split during imaginal development of Drosophila melanogaster. 
  • Accelerated cell cycles enable organ regeneration under developmental time constraints in the Drosophila hindgut. 
  • Actin dynamics: the arp2/3 complex branches out. 
  • Addition of molecular methods to mutation studies with Drosophila melanogaster. 
  • Alpha-amanitin-resistant D. melanogaster with an altered RNA polymerase II. 
  • Amanitin-resistant RNA polymerase II mutations are in the enzyme's largest subunit. 
  • Amino acids important in enzyme activity and dimer stability for Drosophila alcohol dehydrogenase. 
  • An Optogenetic Method to Study Signal Transduction in Intestinal Stem Cell Homeostasis. 
  • An entirely cell-based system to generate single-chain antibodies against cell surface receptors. 
  • Analyses of promoter-proximal pausing by RNA polymerase II on the hsp70 heat shock gene promoter in a Drosophila nuclear extract. 
  • Analysis of Drosophila melanogaster satellite IV with restriction endonuclease MboII. 
  • Analysis of ENU-induced mutations at the Adh locus in Drosophila melanogaster. 
  • Analysis of the gene encoding the largest subunit of RNA polymerase II in Drosophila. 
  • Apolipoprotein E-mimetics inhibit neurodegeneration and restore cognitive functions in a transgenic Drosophila model of Alzheimer's disease. 
  • Apoptosis in Drosophila: neither fish nor fowl (nor man, nor worm). 
  • Apoptotic force and tissue dynamics during Drosophila embryogenesis. 
  • Argonaute2 suppresses Drosophila fragile X expression preventing neurogenesis and oogenesis defects. 
  • Arl2- and Msps-dependent microtubule growth governs asymmetric division. 
  • Assaying CTD kinases in vitro and phosphorylation-modulated properties of RNA polymerase II in vivo. 
  • Automatic annotation of spatial expression patterns via sparse Bayesian factor models. 
  • Avidity and Cell Uptake of Integrin-Targeting Polypeptide Micelles is Strongly Shape-Dependent. 
  • B56-associated protein phosphatase 2A is required for survival and protects from apoptosis in Drosophila melanogaster. 
  • Balancing different types of actin polymerization at distinct sites: roles for Abelson kinase and Enabled. 
  • Behavioral and circuit basis of sucrose rejection by Drosophila females in a simple decision-making task. 
  • Behavioral and physiological responses of Drosophila melanogaster and D. suzukii to volatiles from plant essential oils. 
  • Bidirectional power stroke by ncd kinesin. 
  • Bleomycin induces the hsp 70 heat shock promoter in cultured cells. 
  • Building organs from buds, branches and tubes. 
  • CCP1 promotes mitochondrial fusion and motility to prevent Purkinje cell neuron loss in pcd mice. 
  • CDK-Regulated Phase Separation Seeded by Histone Genes Ensures Precise Growth and Function of Histone Locus Bodies. 
  • CDK12 is a transcription elongation-associated CTD kinase, the metazoan ortholog of yeast Ctk1. 
  • CRL4Mahj E3 ubiquitin ligase promotes neural stem cell reactivation. 
  • Calcium binding by synaptotagmin's C2A domain is an essential element of the electrostatic switch that triggers synchronous synaptic transmission. 
  • Cardiomyopathy is associated with ribosomal protein gene haplo-insufficiency in Drosophila melanogaster. 
  • Cell Sheet Morphogenesis: Dorsal Closure in Drosophila melanogaster as a Model System. 
  • Cell ingression and apical shape oscillations during dorsal closure in Drosophila. 
  • Cell patterning in the Drosophila segment: engrailed and wingless antigen distributions in segment polarity mutant embryos. 
  • Cellularization in Drosophila melanogaster is disrupted by the inhibition of rho activity and the activation of Cdc42 function. 
  • Centromeric chromatin exhibits a histone modification pattern that is distinct from both euchromatin and heterochromatin. 
  • Challenge of Drosophila melanogaster with Cryptococcus neoformans and role of the innate immune response. 
  • Changes in the pattern of adherens junction-associated beta-catenin accompany morphogenesis in the sea urchin embryo. 
  • Characterization of Gfat1 (zeppelin) and Gfat2, Essential Paralogous Genes Which Encode the Enzymes That Catalyze the Rate-Limiting Step in the Hexosamine Biosynthetic Pathway in Drosophila melanogaster. 
  • Characterization of a Drosophila U snRNP RNA-binding protein. 
  • Characterization of cis-regulatory elements controlling repo transcription in Drosophila melanogaster. 
  • Charge substitutions at the voltage-sensing module of domain III enhance actions of site-3 and site-4 toxins on an insect sodium channel. 
  • Chromatin Modulatory Proteins and Olfactory Receptor Signaling in the Refinement and Maintenance of Fruitless Expression in Olfactory Receptor Neurons. 
  • Chromatin-based reprogramming of a courtship regulator by concurrent pheromone perception and hormone signaling. 
  • Chromophore-Independent Roles of Opsin Apoproteins in Drosophila Mechanoreceptors. 
  • Chromosomal distribution of the major insert in Drosophila melanogaster 28S rRNA genes. 
  • Chromosome breakage in Drosophila melanogaster induced by a monofunctional alkylating agent (EMS). 
  • Chromosome distribution, molecular motors and the claret protein. 
  • Chromosome mutation tests for mutagenesis in Drosophila melanogaster. A report of the U.S. Environmental Protection Agency Gene-Tox Program. 
  • Cold temperature improves mobility and survival in Drosophila models of autosomal-dominant hereditary spastic paraplegia (AD-HSP). 
  • Collaborative interactions between MEF-2 and Sp1 in muscle-specific gene regulation. 
  • Comparative analysis of behavioral and transcriptional variation underlying CO₂ sensory neuron function and development in Drosophila. 
  • Comparative analysis of metazoan chromatin organization. 
  • Comparative genome sequencing of Drosophila pseudoobscura: chromosomal, gene, and cis-element evolution. 
  • Comparison of a chemical assay with a tissue-mediated bio-assay for chemical mutagens. 
  • Comparison of dose-response relationships for ethyl methanesulfonate and 1-ethyl-1-nitrosourea in Drosophila melanogaster spermatozoa. 
  • Complete canthi removal reveals that forces from the amnioserosa alone are sufficient to drive dorsal closure in Drosophila. 
  • Complete sequence of the Drosophila nonmuscle myosin heavy-chain transcript: conserved sequences in the myosin tail and differential splicing in the 5' untranslated sequence. 
  • Comprehensive analysis of the chromatin landscape in Drosophila melanogaster. 
  • Computational analysis of core promoters in the Drosophila genome. 
  • Connecting recombination, nucleotide diversity and species divergence in Drosophila. 
  • Consequences of recombination rate variation on quantitative trait locus mapping studies. Simulations based on the Drosophila melanogaster genome. 
  • Constitutive magnification by the Ybb- chromosome of Drosophila melanogaster. 
  • Correction for differences in germ cell stage sensitivity in risk assessment. 
  • Coupled oscillators coordinate collective germline growth. 
  • Crosstalk rejection in parallel optical coherence tomography using spatially incoherent illumination with partially coherent sources. 
  • Cysteine 70 of ankyrin-G is S-palmitoylated and is required for function of ankyrin-G in membrane domain assembly. 
  • Cytokinesis proteins Tum and Pav have a nuclear role in Wnt regulation. 
  • Cytoplasmic myosin from Drosophila melanogaster. 
  • Cytoplasmic sharing through apical membrane remodeling. 
  • DNA copy number evolution in Drosophila cell lines. 
  • DNA sequence analysis of X-ray induced Adh null mutations in Drosophila melanogaster. 
  • DSC1 channel-dependent developmental regulation of pyrethroid susceptibility in Drosophila melanogaster. 
  • Determinants of kinesin motor polarity. 
  • Developmental control of gene copy number by repression of replication initiation and fork progression. 
  • Developmental control of the DNA replication and transcription programs. 
  • Differences in (G+C) content between species: a commentary on Forsdyke's "chromosomal viewpoint" of speciation. 
  • Differences in crossover frequency and distribution among three sibling species of Drosophila. 
  • Differential effects of TipE and a TipE-homologous protein on modulation of gating properties of sodium channels from Drosophila melanogaster. 
  • Differential replication of ribosomal gene repeats in polytene nuclei of Drosophila. 
  • Differential requirement for STAT by gain-of-function and wild-type receptor tyrosine kinase Torso in Drosophila. 
  • Direct ribosomal binding by a cellular inhibitor of translation. 
  • Disruption of sarcoendoplasmic reticulum calcium ATPase function in Drosophila leads to cardiac dysfunction. 
  • Distinct effects of tafazzin deletion in differentiated and undifferentiated mitochondria. 
  • Distinct modulating effects of TipE-homologs 2-4 on Drosophila sodium channel splice variants. 
  • Distinct responses to rare codons in select Drosophila tissues. 
  • Distinct roles of the DmNav and DSC1 channels in the action of DDT and pyrethroids. 
  • Distribution of RNA polymerase on Drosophila polytene chromosomes as studied by indirect immunofluorescence. 
  • Dosage-response relationships for methyl methanesulfonate in Drosophila melanogaster spermatozoa: DNA methylation per nucleotide vs. sex-linked recessive lethal frequency. 
  • Dosimetry of the chemical mutagen ethyl methanesulfonate in spermatozoan DNA from Drosophila melanogaster. 
  • Drosophila APC2 and Armadillo participate in tethering mitotic spindles to cortical actin 
  • Drosophila APC2 is a cytoskeletally-associated protein that regulates wingless signaling in the embryonic epidermis. 
  • Drosophila CTP synthase regulates collective cell migration by controlling the polarized endocytic cycle. 
  • Drosophila ORC localizes to open chromatin and marks sites of cohesin complex loading. 
  • Drosophila PIWI associates with chromatin and interacts directly with HP1a. 
  • Drosophila as a model for the identification of genes causing adult human heart disease. 
  • Drosophila crinkled, mutations of which disrupt morphogenesis and cause lethality, encodes fly myosin VIIA. 
  • Drosophila egg-laying site selection as a system to study simple decision-making processes. 
  • Drosophila melanogaster larvae as a model for blast lung injury. 
  • Drosophila melanogaster ma-l mutants are defective in the sulfuration of desulfo Mo hydroxylases. 
  • Drosophila muller f elements maintain a distinct set of genomic properties over 40 million years of evolution. 
  • Drosophila mutants suggest a strong drive toward complexity in evolution 
  • Drosophila p120catenin plays a supporting role in cell adhesion but is not an essential adherens junction component. 
  • Drosophila spectrin: the membrane skeleton during embryogenesis. 
  • Drosophila stretchin-MLCK is a novel member of the Titin/Myosin light chain kinase family. 
  • Drosophila topo IIIalpha is required for the maintenance of mitochondrial genome and male germ-line stem cells. 
  • Drosophila, genetic screens, and cardiac function. 
  • Dynamic changes in the distribution of cytoplasmic myosin during Drosophila embryogenesis. 
  • Ecdysone-inducible gene expression in mammalian cells and transgenic mice. 
  • Effect of mutagen-induced cell lethality on the dose response of germline mutations. 
  • Egg-laying demand induces aversion of UV light in Drosophila females. 
  • Embryonic lethal abnormal visual RNA-binding proteins involved in growth, differentiation, and posttranscriptional gene expression. 
  • Emergent properties during dorsal closure in Drosophila morphogenesis. 
  • Epiregulin and EGFR interactions are involved in pain processing. 
  • Epithelial morphogenesis: apoptotic forces drive cell shape changes. 
  • Essential light chain of Drosophila nonmuscle myosin II. 
  • Evaluating old truths: Final adult size in holometabolous insects is set by the end of larval development. 
  • Evidence of off-target effects associated with long dsRNAs in Drosophila melanogaster cell-based assays. 
  • Evolution in action: giant ankyrins awake. 
  • Evolution of the 12 kDa FK506-binding protein gene. 
  • Evolutionary biology: Genes to make new species. 
  • Evolutionary history of microsatellites in the obscura group of Drosophila. 
  • Exploiting codon usage identifies intensity-specific modifiers of Ras/MAPK signaling in vivo. 
  • Exponential distance statistics to detect the effects of population subdivision. 
  • Expression and functional analysis of Gm114, a putative mammalian ortholog of Drosophila bam. 
  • Expression and modification of Hox 2.1 protein in mouse embryos. 
  • FIGQY phosphorylation defines discrete populations of L1 cell adhesion molecules at sites of cell-cell contact and in migrating neurons. 
  • Fidelity in planar cell polarity signalling. 
  • Fine-scale mapping of recombination rate in Drosophila refines its correlation to diversity and divergence. 
  • Fizzy-Related dictates A cell cycle switch during organ repair and tissue growth responses in the Drosophila hindgut. 
  • Flying at the head of the pack: Wnt biology in Drosophila. 
  • Function of the hydrophilic carboxyl terminus of type II DNA topoisomerase from Drosophila melanogaster. I. In vitro studies. 
  • Function of the hydrophilic carboxyl terminus of type II DNA topoisomerase from Drosophila melanogaster. II. In vivo studies. 
  • Functional analysis of Wingless reveals a link between intercellular ligand transport and dorsal-cell-specific signaling. 
  • Functional conservation of human Spastin in a Drosophila model of autosomal dominant-hereditary spastic paraplegia. 
  • Functional genomic analysis of phagocytosis and identification of a Drosophila receptor for E. coli. 
  • Functional organization of polytene chromosomes. 
  • Functional reconstitution of purified metabotropic glutamate receptor expressed in the fly eye. 
  • Functional studies of the carboxy-terminal repeat domain of Drosophila RNA polymerase II in vivo. 
  • Functional variants in TBX2 are associated with a syndromic cardiovascular and skeletal developmental disorder. 
  • Fusome topology and inheritance during insect gametogenesis. 
  • Galactokinase is a novel modifier of calcineurin-induced cardiomyopathy in Drosophila. 
  • Gene deletion screen for cardiomyopathy in adult Drosophila identifies a new notch ligand. 
  • Gene expression divergence and the origin of hybrid dysfunctions. 
  • Gene transposition as a cause of hybrid sterility in Drosophila. 
  • Genetic DISC-section of regeneration in Drosophila. 
  • Genetic analysis demonstrates a direct link between rho signaling and nonmuscle myosin function during Drosophila morphogenesis. 
  • Genetic and biochemical characterization of mutants at an RNA polymerase II locus in D. melanogaster. 
  • Genetic control of cuticle formation during embryonic development of Drosophila melanogaster. 
  • Genetic dissection of leukemia-associated IDH1 and IDH2 mutants and D-2-hydroxyglutarate in Drosophila. 
  • Genetic interaction screens identify a role for hedgehog signaling in Drosophila border cell migration. 
  • Genetic network identification using convex programming. 
  • Genetically Encoded Cholesterol-Modified Polypeptides. 
  • Genetics of parkin-linked disease. 
  • Genome annotation assessment in Drosophila melanogaster. 
  • Genome-wide patterns of expression in Drosophila pure species and hybrid males. II. Examination of multiple-species hybridizations, platforms, and life cycle stages. 
  • Glutamate-binding affinity of Drosophila metabotropic glutamate receptor is modulated by association with lipid rafts. 
  • Glycosylated recombinant human XCL1/lymphotactin exhibits enhanced biologic activity. 
  • H2O2-Sensitive Isoforms of Drosophila melanogaster TRPA1 Act in Bitter-Sensing Gustatory Neurons to Promote Avoidance of UV During Egg-Laying. 
  • HDAC6 rescues neurodegeneration and provides an essential link between autophagy and the UPS. 
  • Haploidy and androgenesis in Drosophila. 
  • Heat shock-induced appearance of RNA polymerase II in karyoskeletal protein-enriched (nuclear "matrix") fractions correlates with transcriptional shutdown in Drosophila melanogaster. 
  • Hel-N1, an RNA-binding protein, is a ligand for an A + U rich region of the GLUT1 3' UTR. 
  • Hel-N1: an autoimmune RNA-binding protein with specificity for 3' uridylate-rich untranslated regions of growth factor mRNAs. 
  • Heterochromatic sequences in a Drosophila whole-genome shotgun assembly. 
  • High Throughput Assay to Examine Egg-Laying Preferences of Individual Drosophila melanogaster. 
  • High frequency of microsatellites in Drosophila pseudoobscura. 
  • High-resolution microscopic methods for the analysis of cellular movements in Drosophila embryos. 
  • How an individual fecundity pattern looks in Drosophila and medflies. 
  • How the analysis of genetic mutations can help us to solve basic problems in gerontology? II. Life extending genetic modifications in budding yeast S. cereviseae, fruit fly D. melanogaster and laboratory mice M. musculus. 
  • How the cytoskeleton helps build the embryonic body plan: models of morphogenesis from Drosophila. 
  • Identification and interaction of multiple genes resulting in DDT resistance in the 91-R strain of Drosophila melanogaster by RNAi approaches. 
  • Identification of Drosophila cytoskeletal proteins by induction of abnormal cell shape in fission yeast. 
  • Identification of a structural gene for a RNA polymerase II polypeptide in Drosophila melanogaster and mammalian species. 
  • Identification of amino acid residues in the insect sodium channel critical for pyrethroid binding. 
  • Identification of an X-ray induced deletion mutant flanked by direct repeats. 
  • Identification of chemical inhibitors to human tissue transglutaminase by screening existing drug libraries. 
  • Identification of co-regulated transcripts affecting male body size in Drosophila. 
  • Identification of core promoter modules in Drosophila and their application in accurate transcription start site prediction. 
  • Identification of four proteins from the small subunit of the mammalian mitochondrial ribosome using a proteomics approach. 
  • Identification of functional elements and regulatory circuits by Drosophila modENCODE. 
  • Identification of multiple odorant receptors essential for pyrethrum repellency in Drosophila melanogaster. 
  • Identification of new batrachotoxin-sensing residues in segment IIIS6 of the sodium channel. 
  • Identification of the gene for fly non-muscle myosin heavy chain: Drosophila myosin heavy chains are encoded by a gene family. 
  • Identification, molecular cloning, and mutagenesis of Saccharomyces cerevisiae RNA polymerase genes. 
  • Identifying Key Genetic Regions for Cell Sheet Morphogenesis on Chromosome 2L Using a Drosophila Deficiency Screen in Dorsal Closure. 
  • Images in cardiovascular medicine: in vivo imaging of the adult Drosophila melanogaster heart with real-time optical coherence tomography. 
  • Immobilized molecular beacons: a new strategy using UV-activated poly(methyl methacrylate) surfaces to provide large fluorescence sensitivities for reporting on molecular association events. 
  • In vitro proteolysis of a large subunit of Drosophila melanogaster RNA polymerase B. 
  • Incomplete Y chromosomes promote magnification in male and female Drosophila. 
  • Individual fecundity and senescence in Drosophila and medfly. 
  • Individual variation in inbreeding depression: the roles of inbreeding history and mutation. 
  • Inhibition of translation and induction of apoptosis by Bunyaviral nonstructural proteins bearing sequence similarity to reaper. 
  • Inositol phosphate kinase 2 is required for imaginal disc development in Drosophila. 
  • Inositol phosphate metabolomics: merging genetic perturbation with modernized radiolabeling methods. 
  • Integrative analysis of gene amplification in Drosophila follicle cells: parameters of origin activation and repression. 
  • Interaction of the polyglutamine protein ataxin-3 with Rad23 regulates toxicity in Drosophila models of Spinocerebellar Ataxia Type 3. 
  • Interorgan regulation of Drosophila intestinal stem cell proliferation by a hybrid organ boundary zone. 
  • Interphase cohesin regulation ensures mitotic fidelity after genome reduplication. 
  • Interpolated markov chains for eukaryotic promoter recognition. 
  • Interrupter sequences that are widely distributed in the Drosophila genome. 
  • Intersection tests for single marker QTL analysis can be more powerful than two marker QTL analysis. 
  • Invertebrate nociception: behaviors, neurons and molecules. 
  • Ion channels contribute to the regulation of cell sheet forces during Drosophila dorsal closure. 
  • Isoleucine 44 Hydrophobic Patch Controls Toxicity of Unanchored, Linear Ubiquitin Chains through NF-κB Signaling. 
  • JNK signaling coordinates integrin and actin functions during Drosophila embryogenesis. 
  • Lattice light-sheet microscopy: imaging molecules to embryos at high spatiotemporal resolution. 
  • Learning a Spatial Task by Trial and Error in Drosophila. 
  • Linearity Versus nonlinearity of offspring-parent regression: an experimental study of Drosophila melanogaster. 
  • Linkage of kdr-type resistance and the para-homologous sodium channel gene in German cockroaches (Blattella germanica). 
  • Localization of RNA polymerase in polytene chromosomes of Drosophila melanogaster. 
  • Localized H3K36 methylation states define histone H4K16 acetylation during transcriptional elongation in Drosophila. 
  • Long-duration animal tracking in difficult lighting conditions. 
  • Loss of Drosophila melanogaster p21-activated kinase 3 suppresses defects in synapse structure and function caused by spastin mutations. 
  • Macro molecular dosimetry. 
  • Magnification of the ribosomal genes in female Drosophila melanogaster. 
  • Magnification: gene amplification by an inducible system of sister chromatid exchange. 
  • Manganese-based superoxide dismutase mimics modify both acute and long-term outcome severity in a Drosophila melanogaster model of classic galactosemia. 
  • Mapping mutations in genes encoding the two large subunits of Drosophila RNA polymerase II defines domains essential for basic transcription functions and for proper expression of developmental genes. 
  • Mapping the complexity of transcription control in higher eukaryotes. 
  • Mature Drosophila meiosis I spindles comprise microtubules of mixed polarity. 
  • Measuring Cellular Ploidy In Situ by Light Microscopy. 
  • Mechanical Properties of a Drosophila Larval Chordotonal Organ. 
  • Mechanical feedback through E-cadherin promotes direction sensing during collective cell migration. 
  • Mechanisms for dominance: Adh heterodimer formation in heterozygotes between ENU or X-ray induced null alleles and normal alleles in Drosophila melanogaster. 
  • Mediation of meiotic and early mitotic chromosome segregation in Drosophila by a protein related to kinesin. 
  • Metabolic regulation of Drosophila apoptosis through inhibitory phosphorylation of Dronc. 
  • Metaphors and the role of genes in development. 
  • Methylation of histone H4 lysine 20 by PR-Set7 ensures the integrity of late replicating sequence domains in Drosophila. 
  • Missense Variants in RHOBTB2 Cause a Developmental and Epileptic Encephalopathy in Humans, and Altered Levels Cause Neurological Defects in Drosophila. 
  • Mitochondrial fusion is regulated by Reaper to modulate Drosophila programmed cell death. 
  • Modeling the evolution of regulatory elements by simultaneous detection and alignment with phylogenetic pair HMMs. 
  • Molecular analysis of Drosophila melanogaster AdhnLA405 confirms reliability of DNA-sequencing methodology. 
  • Molecular analysis of X-ray-induced alcohol dehydrogenase (ADH) null mutations in Drosophila melanogaster. 
  • Molecular analysis of alcohol dehydrogenase electromorphs in wild type and transformed Drosophila melanogaster. 
  • Molecular and functional characterization of voltage-gated sodium channel variants from Drosophila melanogaster. 
  • Molecular characterization and functional expression of the DSC1 channel. 
  • Molecular characterization of ribosomal genes on the Ybb- chromosome of Drosophila melanogaster. 
  • Molecular cloning of sequences from a Drosophila RNA polymerase II locus by P element transposon tagging. 
  • Molecular dosimetry of the mutagen ethyl methanesulfonate in Drosophila melanogaster spermatozoa: linear relation of DNA alkylation per sperm cell (dose) to sex-linked recessive lethals. 
  • Molecular mechanisms of mutagenesis determined by recombinant DNA technology. 
  • Molecular organization and alternative splicing in zipper, the gene that encodes the Drosophila non-muscle myosin II heavy chain. 
  • Morphogenesis: multitalented GTPases seeking new jobs. 
  • Motif composition, conservation and condition-specificity of single and alternative transcription start sites in the Drosophila genome. 
  • Multi-ethnic GWAS and meta-analysis of sleep quality identify MPP6 as a novel gene that functions in sleep center neurons. 
  • Mutant alleles of the meiotic locus, mei-9, differ in degree of effects on rod chromosome magnification and ring chromosome transmission in Drosophila. 
  • Mutants of the Drosophila ncd microtubule motor protein cause centrosomal and spindle pole defects in mitosis. 
  • Mutation and evolution of microsatellites in Drosophila melanogaster. 
  • Mutation spectrum of 2-chloroethyl methanesulfonate in Drosophila melanogaster premeiotic germ cells. 
  • Mutations in Drosophila crinkled/Myosin VIIA disrupt denticle morphogenesis. 
  • Mutations in the segment polarity genes wingless and porcupine impair secretion of the wingless protein. 
  • Myosins motor Miranda. 
  • Native nonmuscle myosin II stability and light chain binding in Drosophila melanogaster. 
  • Negative cross-resistance of a pyrethroid-resistant Drosophila mutant to Phryma leptostachya-derived haedoxan A. 
  • Neural circuits. Labeling of active neural circuits in vivo with designed calcium integrators. 
  • New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk. 
  • Nonconsensus Protein Binding to Repetitive DNA Sequence Elements Significantly Affects Eukaryotic Genomes. 
  • Nonmuscle myosin II is required for cell proliferation, cell sheet adhesion and wing hair morphology during wing morphogenesis. 
  • Novel sodium channel gene mutations in Blattella germanica reduce the sensitivity of expressed channels to deltamethrin. 
  • Nucleosome Turnover Regulates Histone Methylation Patterns over the Genome. 
  • On ribosomal gene compensation in Drosophila. 
  • One-step and stepwise magnification of a bobbed lethal chromosome in Drosophila melanogaster. 
  • Overlapping transcription units in the transient receptor potential locus of Drosophila melanogaster. 
  • PAS is a dimerization domain common to Drosophila period and several transcription factors. 
  • PCR-Based Determination of Mitochondrial DNA Copy Number in Multiple Species. 
  • PER protein interactions and temperature compensation of a circadian clock in Drosophila. 
  • Paleo-demography of the Drosophila melanogaster subgroup: application of the maximum likelihood method. 
  • Pebble/ECT2 RhoGEF negatively regulates the Wingless/Wnt signaling pathway. 
  • Peptidoglycan-Sensing Receptors Trigger the Formation of Functional Amyloids of the Adaptor Protein Imd to Initiate Drosophila NF-κB Signaling. 
  • Persistent DNA damage signaling and DNA polymerase theta promote broken chromosome segregation. 
  • Pharmacological characterization and immunoaffinity purification of metabotropic glutamate receptor from Drosophila overexpressed in Sf9 cells. 
  • Piezo proteins are pore-forming subunits of mechanically activated channels. 
  • Polytenization of the ribosomal genes on the X and Y chromosomes of Drosophila melanogaster. 
  • Post-translational modifications regulate the ticking of the circadian clock. 
  • Preferential re-replication of Drosophila heterochromatin in the absence of geminin. 
  • Proliferation of Double-Strand Break-Resistant Polyploid Cells Requires Drosophila FANCD2. 
  • Promoter prediction on a genomic scale--the Adh experience. 
  • Properties of mutationally altered RNA polymerases II of Drosophila. 
  • Protein kinase C phosphorylates nonmuscle myosin-II heavy chain from Drosophila but regulation of myosin function by this enzyme is not required for viability in flies. 
  • Protein phosphatase 2A regulates self-renewal of Drosophila neural stem cells. 
  • Protein serine/threonine phosphatases--new avenues for cell regulation. 
  • Purification of kinesin-related protein complexes from eggs and embryos. 
  • Putative human blue-light photoreceptors hCRY1 and hCRY2 are flavoproteins. 
  • Quantitative models of hybrid dysgenesis: rapid evolution under transposition, extrachromosomal inheritance, and fertility selection. 
  • RNA binding specificity of a Drosophila snRNP protein that shares sequence homology with mammalian U1-A and U2-B" proteins. 
  • RNA polymerase B (or II) in heat induced puffs of Drosophila polytene chromosomes. 
  • RNA polymerase B from Drosophila melanogaster larvae. Purification and partial characterization. 
  • Rab11 helps maintain apical crumbs and adherens junctions in the Drosophila embryonic ectoderm. 
  • Rapid double 8-nm steps by a kinesin mutant. 
  • Reaction mechanism of (6-4) photolyase. 
  • Real-time imaging of morphogenetic movements in Drosophila using Gal4-UAS-driven expression of GFP fused to the actin-binding domain of moesin. 
  • Reaper-induced apoptosis in a vertebrate system. 
  • Reaper-induced dissociation of a Scythe-sequestered cytochrome c-releasing activity. 
  • Reduced life span with heart and muscle dysfunction in Drosophila sarcoglycan mutants. 
  • Regulation of Frizzled by fat-like cadherins during planar polarity signaling in the Drosophila compound eye. 
  • Regulation of synaptic connectivity by glia. 
  • Remodeling Tissue Interfaces and the Thermodynamics of Zipping during Dorsal Closure in Drosophila. 
  • Reverse genetics of Drosophila RNA polymerase II: identification and characterization of RpII140, the genomic locus for the second-largest subunit. 
  • Rhodopsin maturation antagonized by dominant rhodopsin mutants. 
  • Ribonomic analysis of human Pum1 reveals cis-trans conservation across species despite evolution of diverse mRNA target sets. 
  • Ring chromosomes and rDNA magnification in Drosophila. 
  • Role of the DSC1 channel in regulating neuronal excitability in Drosophila melanogaster: extending nervous system stability under stress. 
  • SMRTER, a Drosophila nuclear receptor coregulator, reveals that EcR-mediated repression is critical for development. 
  • STING'ing Zika virus in neurons. 
  • Satellite DNA sequences of Drosophila melanogaster. 
  • Scythe: a novel reaper-binding apoptotic regulator. 
  • Self-Organized Nuclear Positioning Synchronizes the Cell Cycle in Drosophila Embryos. 
  • Sensory integration and neuromodulatory feedback facilitate Drosophila mechanonociceptive behavior. 
  • Sequence variations at I260 and A1731 contribute to persistent currents in Drosophila sodium channels. 
  • Serotonergic Modulation Enables Pathway-Specific Plasticity in a Developing Sensory Circuit in Drosophila. 
  • Sestrin mediates detection of and adaptation to low-leucine diets in Drosophila. 
  • Seven-up inhibits ultraspiracle-based signaling pathways in vitro and in vivo. 
  • Signaling by wingless in Drosophila. 
  • Single-target molecule detection with nonbleaching multicolor optical immunolabels. 
  • Site-directed mutagenesis of glycine-14 and two "critical" cysteinyl residues in Drosophila alcohol dehydrogenase. 
  • Site-specific mutagenesis of Drosophila alcohol dehydrogenase: evidence for involvement of tyrosine-152 and lysine-156 in catalysis. 
  • Sites of P element insertion and structures of P element deletions in the 5' region of Drosophila melanogaster RpII215. 
  • Social Context Enhances Hormonal Modulation of Pheromone Detection in Drosophila. 
  • Sonic Hedgehog-induced proliferation requires specific Gα inhibitory proteins. 
  • SoxNeuro and Shavenbaby act cooperatively to shape denticles in the embryonic epidermis of Drosophila . 
  • Sp1 activation of a TATA-less promoter requires a species-specific interaction involving transcription factor IID. 
  • Sprinter: a novel transmembrane protein required for Wg secretion and signaling. 
  • Stall encodes an ADAMTS metalloprotease and interacts genetically with Delta in Drosophila ovarian follicle formation. 
  • Statistical structure of locomotion and its modulation by odors. 
  • Steroid and high-temperature induction of the small heat-shock protein genes in Drosophila. 
  • Stochastic segment models of eukaryotic promoter regions. 
  • Strand-specific mismatch correction in nuclear extracts of human and Drosophila melanogaster cell lines. 
  • Stress resistance declines with age: analysis of data from a survival experiment with Drosophila melanogaster. 
  • Structure of the eukaryotic transcription apparatus: features of the gene for the largest subunit of Drosophila RNA polymerase II. 
  • Structure of the genes encoding transcription factor IIB and TATA box-binding protein from Drosophila melanogaster. 
  • Studying recombination with high-throughput sequencing: an educational primer for use with "fine-scale heterogeneity in crossover rate in the garnet-scalloped region of the Drosophila melanogaster X chromosome". 
  • Subsecond multichannel magnetic control of select neural circuits in freely moving flies. 
  • Success of mutant Drosophila at different sex ratios. 
  • Sustained-input switches for transcription factors and microRNAs are central building blocks of eukaryotic gene circuits. 
  • Sweet neurons inhibit texture discrimination by signaling TMC-expressing mechanosensitive neurons in Drosophila. 
  • Temperature-Induced uncoupling of cell cycle regulators. 
  • Testing hypotheses for the functions of APC family proteins using null and truncation alleles in Drosophila. 
  • The C-terminal 20 Amino Acids of Drosophila Topoisomerase 2 Are Required for Binding to a BRCA1 C Terminus (BRCT) Domain-containing Protein, Mus101, and Fidelity of DNA Segregation. 
  • The C-terminal repeat domain of RNA polymerase II largest subunit is essential in vivo but is not required for accurate transcription initiation in vitro. 
  • The DVR gene family in embryonic development. 
  • The Dh gene of Drosophila melanogaster encodes a diuretic peptide that acts through cyclic AMP. 
  • The Drosophila Cadherin Fat regulates tissue size and planar cell polarity through different domains. 
  • The Drosophila Tis11 protein and its effects on mRNA expression in flies. 
  • The Drosophila Translational Control Element (TCE) is required for high-level transcription of many genes that are specifically expressed in testes. 
  • The Drosophila afadin homologue Canoe regulates linkage of the actin cytoskeleton to adherens junctions during apical constriction. 
  • The Drosophila ncd microtubule motor protein is spindle-associated in meiotic and mitotic cells. 
  • The Saccharomyces and Drosophila heat shock transcription factors are identical in size and DNA binding properties. 
  • The actin membrane skeleton in Drosophila development. 
  • The claret locus in Drosophila encodes products required for eyecolor and for meiotic chromosome segregation. 
  • The developmental control of size in insects. 
  • The downstream core promoter element, DPE, is conserved from Drosophila to humans and is recognized by TAFII60 of Drosophila. 
  • The fruitless gene is required for the proper formation of axonal tracts in the embryonic central nervous system of Drosophila. 
  • The histone modification pattern of active genes revealed through genome-wide chromatin analysis of a higher eukaryote. 
  • The influence of large deletions on the mutation frequency induced by tritiated water and X-radiation in male Drosophila melanogaster post-meiotic germ cells. 
  • The mechanical properties of early Drosophila embryos measured by high-speed video microrheology. 
  • The p35 relative, p49, inhibits mammalian and Drosophila caspases including DRONC and protects against apoptosis. 
  • The phosphoCTD-interacting domain of Topoisomerase I. 
  • The regulatory light chain of nonmuscle myosin is encoded by spaghetti-squash, a gene required for cytokinesis in Drosophila. 
  • The role of HOM-C genes in segmental transformations: reexamination of the Drosophila Sex combs reduced embryonic phenotype. 
  • The segment polarity gene porcupine encodes a putative multitransmembrane protein involved in Wingless processing. 
  • The sex-linked recessive lethal test for mutagenesis in Drosophila melanogaster. A report of the U.S. Environmental Protection Agency Gene-Tox Program. 
  • The small subunit of the mammalian mitochondrial ribosome. Identification of the full complement of ribosomal proteins present. 
  • The strength and periodicity of D. melanogaster circadian rhythms are differentially affected by alterations in period gene expression. 
  • The two-pore domain potassium channel TREK-1 mediates cardiac fibrosis and diastolic dysfunction. 
  • Thermosensory and nonthermosensory isoforms of Drosophila melanogaster TRPA1 reveal heat-sensor domains of a thermoTRP Channel. 
  • Tissue Sculpting by Fibrils. 
  • Tornadic Shear Stress Induces a Transient, Calcineurin-Dependent Hypervirulent Phenotype in Mucorales Molds. 
  • Transcription initiation patterns indicate divergent strategies for gene regulation at the chromatin level. 
  • Transcriptional Timers Regulating Mitosis in Early Drosophila Embryos. 
  • Transcriptional repressor functions of Drosophila E2F1 and E2F2 cooperate to inhibit genomic DNA synthesis in ovarian follicle cells. 
  • Transmutation of carbon-14 within DNA of Drosophila melanogaster spermatozoa. 
  • Triggering a cell shape change by exploiting preexisting actomyosin contractions. 
  • Tum/RacGAP50C provides a critical link between anaphase microtubules and the assembly of the contractile ring in Drosophila melanogaster. 
  • Two chemosensory receptors together mediate carbon dioxide detection in Drosophila. 
  • USP5 Is Dispensable for Monoubiquitin Maintenance in Drosophila. 
  • Ubiquitin-binding site 2 of ataxin-3 prevents its proteasomal degradation by interacting with Rad23. 
  • Ubiquitination regulates the neuroprotective function of the deubiquitinase ataxin-3 in vivo. 
  • Unexpected role of interferon-γ in regulating neuronal connectivity and social behaviour. 
  • Unlocking the secrets of the genome. 
  • Use of time-lapse imaging and dominant negative receptors to dissect the steroid receptor control of neuronal remodeling in Drosophila. 
  • Using Bcr-Abl to examine mechanisms by which abl kinase regulates morphogenesis in Drosophila. 
  • Viscera affectum anno: the gut beyond eating behaviours. 
  • Visualization of replication initiation and elongation in Drosophila. 
  • Wnt signalling shows its versatility. 
  • Wound healing: The power of the purse string. 
  • [Investigation of neuroprotective activity of apolipoprotein E peptide mimetic Cog1410 in transgenic lines of Drosophila melanogaster]. 
  • [Protein transduction domain peptide mediates delivery to the brain via the blood-brain barrier in Drosophila]. 
  • [Studying pathogenesis of Alzheimer's disease in a Drosophila melanogaster model: human APP overexpression in the brain of transgenic flies leads to deficit of the synaptic protein synaptotagmin]. 
  • bullwinkle is required for epithelial morphogenesis during Drosophila oogenesis. 
  • cis-Proline-mediated Ser(P)5 dephosphorylation by the RNA polymerase II C-terminal domain phosphatase Ssu72. 
  • crinkled reveals a new role for Wingless signaling in Drosophila denticle formation. 
  • mirror controls planar polarity and equator formation through repression of fringe expression and through control of cell affinities. 
  • speck, First Identified in Drosophila melanogaster in 1910, Is Encoded by the Arylalkalamine N-Acetyltransferase (AANAT1) Gene. 
  • ¹H, ¹³C and ¹⁵N backbone and side-chain resonance assignments of Drosophila melanogaster Ssu72. 
• 

  Keywords of People

  • Bejsovec, Amy, Associate Professor of Biology, Biology
  • Erickson, Harold Paul, James B. Duke Distinguished Professor Emeritus, Cell Biology
  • Gordan, Raluca Mihaela, Associate Professor in Biostatistics & Bioinformatics, Computer Science
  • Hartemink, Alexander J., Professor in the Department of Computer Science, Biology
  • Hogan, Brigid L. M., Research Professor of Cell Biology, Cell Biology
  • Kiehart, Daniel P., Professor of Biology, Duke Science & Society
  • Pitt, Geoffrey Stuart, Adjunct Professor in the Department of Medicine, Medicine, Cardiology