Drug Carriers

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  Subject Areas on Research

  • A dual-ligand approach for enhancing targeting selectivity of therapeutic nanocarriers. 
  • A gene therapy strategy using a transcription factor decoy of the E2F binding site inhibits smooth muscle proliferation in vivo. 
  • A new temperature-sensitive liposome for use with mild hyperthermia: characterization and testing in a human tumor xenograft model. 
  • A phase I trial of preventive HIV vaccination with heterologous poxviral-vectors containing matching HIV-1 inserts in healthy HIV-uninfected subjects. 
  • A quantitative study of the intracellular fate of pH-responsive doxorubicin-polypeptide nanoparticles. 
  • A serum-resistant cytofectin for cellular delivery of antisense oligodeoxynucleotides and plasmid DNA. 
  • A targeted and adjuvanted nanocarrier lowers the effective dose of liposomal amphotericin B and enhances adaptive immunity in murine cutaneous leishmaniasis. 
  • A tracer dose of technetium-99m-labeled liposomes can estimate the effect of hyperthermia on intratumoral doxil extravasation. 
  • Accelerated wound healing by injectable star poly(ethylene glycol)-b-poly(propylene sulfide) scaffolds loaded with poorly water-soluble drugs. 
  • Acetalated Dextran Microparticles for Codelivery of STING and TLR7/8 Agonists. 
  • An assessment of the effects of shell cross-linked nanoparticle size, core composition, and surface PEGylation on in vivo biodistribution. 
  • Anti-invasive adjuvant therapy with imipramine blue enhances chemotherapeutic efficacy against glioma. 
  • Apoferritin protein cages: a novel drug nanocarrier for photodynamic therapy. 
  • Applications of elastin-like polypeptides in drug delivery. 
  • Aptamer-mediated delivery of chemotherapy to pancreatic cancer cells. 
  • Aqueous self-assembly of poly(ethylene oxide)-block-poly(ε-caprolactone) (PEO-b-PCL) copolymers: disparate diblock copolymer compositions give rise to nano- and meso-scale bilayered vesicles. 
  • Biodegradable Shape Memory Polymers in Medicine. 
  • Biomaterial-assisted local and systemic delivery of bioactive agents for bone repair. 
  • Blood-brain barrier-penetrating amphiphilic polymer nanoparticles deliver docetaxel for the treatment of brain metastases of triple negative breast cancer. 
  • CD40L-adjuvanted DNA/modified vaccinia virus Ankara simian immunodeficiency virus SIV239 vaccine enhances SIV-specific humoral and cellular immunity and improves protection against a heterologous SIVE660 mucosal challenge. 
  • Cell penetration properties of maurocalcine, a natural venom peptide active on the intracellular ryanodine receptor. 
  • Cell-internalization SELEX: method for identifying cell-internalizing RNA aptamers for delivering siRNAs to target cells. 
  • Cellular and molecular targeting for nanotherapeutics in transplantation tolerance. 
  • Cellular uptake and photodynamic activity of protein nanocages containing methylene blue photosensitizing drug. 
  • Cerebral lymphoma in an adenosine deaminase-deficient patient with severe combined immunodeficiency receiving polyethylene glycol-conjugated adenosine deaminase. 
  • Characterization of restricted diffusion in uni- and multi-lamellar vesicles using short distance iMQCs. 
  • Chemistry. Nanomaterials for drug delivery. 
  • Chest discomfort associated with liposomal amphotericin B: report of three cases and review of the literature. 
  • Choice of vehicle affects pyraclostrobin toxicity in mice. 
  • Class I restricted CTL recognition of a soluble protein delivered by liposomes containing lipophilic polylysines. 
  • Clinical benefits of pegylated proteins in oncology. 
  • Clinical uses of pegylated pharmaceuticals in oncology. 
  • Collagen shield delivery of tissue plasminogen activator: functional and pharmacokinetic studies of anterior segment delivery. 
  • Comparison of antibiotic beads and intravenous antibiotics in open fractures. 
  • Computationally guided high-throughput design of self-assembling drug nanoparticles. 
  • Control of SIV infection and subsequent induction of pandemic H1N1 immunity in rhesus macaques using an Ad5 [E1-, E2b-] vector platform. 
  • Cytosolic delivery of macromolecules: I. Synthesis and characterization of pH-sensitive acyloxyalkylimidazoles. 
  • Delivery of antisense oligonucleotides using HPMA polymer: synthesis of A thiol polymer and its conjugation to water-soluble molecules. 
  • Design of thermally responsive, recombinant polypeptide carriers for targeted drug delivery. 
  • Developing Precisely Defined Drug-Loaded Nanoparticles by Ring-Opening Polymerization of a Paclitaxel Prodrug. 
  • Development of a novel adjuvanted nasal vaccine: C48/80 associated with chitosan nanoparticles as a path to enhance mucosal immunity. 
  • Directed axonal outgrowth using a propagating gradient of IGF-1. 
  • Doxorubicin-conjugated chimeric polypeptide nanoparticles that respond to mild hyperthermia. 
  • Doxorubicin-loaded protease-activated near-infrared fluorescent polymeric nanoparticles for imaging and therapy of cancer. 
  • Dressing up Nanoparticles: A Membrane Wrap to Induce Formation of the Virological Synapse. 
  • Drug Coated Balloon Angioplasty in Failing AV Fistulas: A Randomized Controlled Trial. 
  • Effectiveness of combined interleukin 2 and B7.1 vaccination strategy is dependent on the sequence and order: a liposome-mediated gene therapy treatment for bladder cancer. 
  • Elastin-Like Polypeptides for Biomedical Applications. 
  • Elastin-like polypeptides: biomedical applications of tunable biopolymers. 
  • Emerging applications of stimuli-responsive polymer materials. 
  • Encapsulation and controlled release of retinol from silicone particles for topical delivery. 
  • Endochondral bone formation from hydrogel carriers loaded with BMP2-transduced cells. 
  • Engineered chimeric streptavidin tetramers as novel tools for bioseparations and drug delivery. 
  • Engineered modular recombinant transporters: application of new platform for targeted radiotherapeutic agents to alpha-particle emitting 211 At. 
  • Enhanced Immune Responses to HIV-1 Envelope Elicited by a Vaccine Regimen Consisting of Priming with Newcastle Disease Virus Expressing HIV gp160 and Boosting with gp120 and SOSIP gp140 Proteins. 
  • Enhanced uptake of a thermally responsive polypeptide by tumor cells in response to its hyperthermia-mediated phase transition. 
  • Evaluation of humoral, mucosal, and cellular immune responses following co-immunization of HIV-1 Gag and Env proteins expressed by Newcastle disease virus. 
  • Exploitation of intracellular pH gradients in the cellular delivery of macromolecules. 
  • Feasibility of laser-targeted photoocclusion of the choriocapillary layer in rats. 
  • From Composition to Cure: A Systems Engineering Approach to Anticancer Drug Carriers. 
  • Fungal phospholipase activity and susceptibility to lipid preparations of amphotericin B. 
  • Fusigenic liposome-mediated DNA transfer into cardiac myocytes. 
  • Fusigenic viral liposome for gene therapy in cardiovascular diseases. 
  • Gelation of liposome interior. A novel method for drug encapsulation. 
  • Gene therapy with an E2F transcription factor decoy inhibits cell cycle progression in rat anti-Thy 1 glomerulonephritis. 
  • Genetically Encoding Albumin Binding into Chemotherapeutic-loaded Polypeptide Nanoparticles Enhances Their Antitumor Efficacy. 
  • Harnessing the power of cell-penetrating peptides: activatable carriers for targeting systemic delivery of cancer therapeutics and imaging agents. 
  • Heuristics for the Optimal Presentation of Bioactive Peptides on Polypeptide Micelles. 
  • Hyperthermia and liposomes. 
  • ICAM-1 expression in autoimmune encephalitis visualized using magnetic resonance imaging. 
  • Importance of integrating nanotechnology with pharmacology and physiology for innovative drug delivery and therapy - an illustration with firsthand examples. 
  • Improving DNA double-strand repair inhibitor KU55933 therapeutic index in cancer radiotherapy using nanoparticle drug delivery. 
  • In Situ Proapoptotic Peptide-Generating Rapeseed Protein-Based Nanocomplexes Synergize Chemotherapy for Cathepsin-B Overexpressing Breast Cancer. 
  • In situ gelling hydrogels for conformal repair of spinal cord defects, and local delivery of BDNF after spinal cord injury. 
  • In vitro characterization of vascular endothelial growth factor and dexamethasone releasing hydrogels for implantable probe coatings. 
  • In vivo fluorescence imaging: a personal perspective. 
  • In vivo tumor targeting by a NGR-decorated micelle of a recombinant diblock copolypeptide. 
  • Induction of Heterologous Tier 2 HIV-1-Neutralizing and Cross-Reactive V1/V2-Specific Antibodies in Rabbits by Prime-Boost Immunization. 
  • Inherently stealthy and highly tumor-selective gold nanoraspberries for photothermal cancer therapy. 
  • Inhibition of implant-associated infections via nitric oxide release. 
  • Initial treatment for chronic hepatitis C: current therapies and their optimal dosing and duration. 
  • Intravitreal liposome-encapsulated drugs: a preliminary human report. 
  • Kupffer cell depletion by CI2MDP-liposomes alters hepatic cytokine expression and delays liver regeneration after partial hepatectomy. 
  • Live attenuated rubella vectors expressing SIV and HIV vaccine antigens replicate and elicit durable immune responses in rhesus macaques. 
  • Localized delivery of DNA to the cells by viral collagen-loaded silica colloidal crystals. 
  • Long-residence-time nano-scale liposomal iohexol for X-ray-based blood pool imaging. 
  • Mucosal Immunization with Newcastle Disease Virus Vector Coexpressing HIV-1 Env and Gag Proteins Elicits Potent Serum, Mucosal, and Cellular Immune Responses That Protect against Vaccinia Virus Env and Gag Challenges. 
  • Multifunctional nanocarriers for mammographic quantification of tumor dosing and prognosis of breast cancer therapy. 
  • Murine granulocyte-macrophage colony-stimulating factor expressed from a bicistronic simian immunodeficiency virus-based integrase-defective lentiviral vector does not enhance T-cell responses in mice. 
  • Nanoantibiotics: a new paradigm for the treatment of surgical infection. 
  • Nanocarrier-mediated inhibition of macrophage migration inhibitory factor attenuates secondary injury after spinal cord injury. 
  • Nanoparticle delivery of chemosensitizers improve chemotherapy efficacy without incurring additional toxicity. 
  • Nanoparticle delivery of chemotherapy combination regimen improves the therapeutic efficacy in mouse models of lung cancer. 
  • Nanoparticle delivery of donor antigens for transplant tolerance in allogeneic islet transplantation. 
  • Nanoparticles for urothelium penetration and delivery of the histone deacetylase inhibitor belinostat for treatment of bladder cancer. 
  • Noninvasive visualization of the choriocapillaris and its dynamic filling. 
  • On Command Drug Delivery via Cell-Conveyed Phototherapeutics. 
  • Optical imaging and analysis of human vaginal coating by drug delivery gels 
  • Optically modulated cancer therapeutic delivery: past, present and future. 
  • Pentablock copolymer dexamethasone nanoformulations elevate MYOC: in vitro liberation, activity and safety in human trabecular meshwork cells. 
  • Performance of Homologous and Heterologous Prime-Boost Immunization Regimens of Recombinant Adenovirus and Modified Vaccinia Virus Ankara Expressing an Ag85B-TB10.4 Fusion Protein against Mycobacterium tuberculosis. 
  • Pharmacokinetic analysis of two-step approaches using bifunctional and enzyme-conjugated antibodies. 
  • Pharmacokinetics of antisense oligodeoxyribonucleotides (cyclin B1 and CDC 2 kinase) in the vessel wall in vivo: enhanced therapeutic utility for restenosis by HVJ-liposome delivery. 
  • Polycationic Nanofibers for Nucleic Acid Scavenging. 
  • Polymersomes: a new multi-functional tool for cancer diagnosis and therapy. 
  • Prevention of restenosis by gene therapy. 
  • Quantitative Mapping of the Spatial Distribution of Nanoparticles in Endo-Lysosomes by Local pH. 
  • Quantitative Study of the Interaction of Multivalent Ligand-Modified Nanoparticles with Breast Cancer Cells with Tunable Receptor Density. 
  • Rational identification of a novel peptide for targeting nanocarriers to 9L glioma. 
  • Recombinant Mycobacterium bovis bacillus Calmette-Guérin vectors prime for strong cellular responses to simian immunodeficiency virus gag in rhesus macaques. 
  • Reduced foreign body response at nitric oxide-releasing subcutaneous implants. 
  • Release and activity of anti-TNFalpha therapeutics from injectable chitosan preparations for local drug delivery. 
  • Remote triggered release of doxorubicin in tumors by synergistic application of thermosensitive liposomes and gold nanorods. 
  • Ring-opening polymerization of prodrugs: a versatile approach to prepare well-defined drug-loaded nanoparticles. 
  • Selective targeting of nanocarriers to neutrophils and monocytes. 
  • Selective visualization of choroidal neovascular membranes. 
  • Self-assembled Lipid Nanoparticles for Ratiometric Codelivery of Cisplatin and siRNA Targeting XPF to Combat Drug Resistance in Lung Cancer. 
  • Self-assembling chimeric polypeptide–doxorubicin conjugate nanoparticles that abolish tumours after a single injection 
  • Self-assembly of thermally responsive nanoparticles of a genetically encoded peptide polymer by drug conjugation. 
  • Simultaneous measurement of liposome extravasation and content release in tumors. 
  • Single intraluminal delivery of antisense cdc2 kinase and proliferating-cell nuclear antigen oligonucleotides results in chronic inhibition of neointimal hyperplasia. 
  • Single-Step Assembly of Multimodal Imaging Nanocarriers: MRI and Long-Wavelength Fluorescence Imaging. 
  • Soluble proteins delivered to dendritic cells via pH-sensitive liposomes induce primary cytotoxic T lymphocyte responses in vitro. 
  • Spatial distribution and acute anti-inflammatory effects of Methylprednisolone after sustained local delivery to the contused spinal cord. 
  • Specificity and 6-month durability of immune responses induced by DNA and recombinant modified vaccinia Ankara vaccines expressing HIV-1 virus-like particles. 
  • Squeezing flows of vaginal gel formulations relevant to microbicide drug delivery. 
  • Stable Expression of Lentiviral Antigens by Quality-Controlled Recombinant Mycobacterium bovis BCG Vectors. 
  • Stimulus-responsive macromolecules and nanoparticles for cancer drug delivery. 
  • Structure and interactive properties of highly fluorinated phospholipid bilayers. 
  • Surface Engineering of FLT4-Targeted Nanocarriers Enhances Cell-Softening Glaucoma Therapy. 
  • Surface modified poly(β amino ester)-containing nanoparticles for plasmid DNA delivery. 
  • Surface-and hydrogel-mediated delivery of nucleic acid nanoparticles 
  • Sustained release of antibiotics from injectable and thermally responsive polypeptide depots. 
  • Systemic toxicology and laser safety of laser targeted angiography with heat sensitive liposomes. 
  • Targeted drug delivery by thermally responsive polymers. 
  • Targeted drug delivery to C6 glioma by transferrin-coupled liposomes. 
  • Targeted gene therapy for rat glomerulonephritis using HVJ-immunoliposomes. 
  • Targeting tumor microvessels using doxorubicin encapsulated in a novel thermosensitive liposome. 
  • Temperature sensitive peptides: engineering hyperthermia-directed therapeutics. 
  • Temperature-sensitive hydrogels with SiO2-Au nanoshells for controlled drug delivery. 
  • The Weak Link: Optimization of the Ligand-Nanoparticle Interface To Enhance Cancer Cell Targeting by Polymer Micelles. 
  • The materials engineering of temperature-sensitive liposomes. 
  • The role of carrier size in the pharmacodynamics of antisense and siRNA oligonucleotides. 
  • The role of cavitation in acoustically activated drug delivery. 
  • Thermosensitive liposomes: extravasation and release of contents in tumor microvascular networks. 
  • Three-Year Durability of Immune Responses Induced by HIV-DNA and HIV-Modified Vaccinia Virus Ankara and Effect of a Late HIV-Modified Vaccinia Virus Ankara Boost in Tanzanian Volunteers. 
  • Top-down particle fabrication: control of size and shape for diagnostic imaging and drug delivery. 
  • Toward a systems engineering approach to cancer drug delivery. 
  • Transfection efficiency and transgene expression kinetics of mRNA delivered in naked and nanoparticle format. 
  • Treatment of Invasive Brain Tumors Using a Chain-like Nanoparticle. 
  • Treatment of neuroinflammation by soluble tumor necrosis factor receptor Type II fused to a thermally responsive carrier. 
  • Triple stimulus-responsive polypeptide nanoparticles that enhance intratumoral spatial distribution. 
  • Tumor Subtype Determines Therapeutic Response to Chimeric Polypeptide Nanoparticle-based Chemotherapy in Pten-deleted Mouse Models of Sarcoma. 
  • Tumor accumulation, degradation and pharmacokinetics of elastin-like polypeptides in nude mice. 
  • Tumor microvascular permeability is a key determinant for antivascular effects of doxorubicin encapsulated in a temperature sensitive liposome. 
  • Tumor vascular permeability, accumulation, and penetration of macromolecular drug carriers. 
  • Tumor-specific anti-epidermal growth factor receptor variant III monoclonal antibodies: use of the tyramine-cellobiose radioiodination method enhances cellular retention and uptake in tumor xenografts. 
  • Tunable leuko-polymersomes that adhere specifically to inflammatory markers. 
  • Uses of nanoparticles for central nervous system imaging and therapy. 
  • Vaccination With Heterologous HIV-1 Envelope Sequences and Heterologous Adenovirus Vectors Increases T-Cell Responses to Conserved Regions: HVTN 083. 
  • Vaccination with Recombinant Cryptococcus Proteins in Glucan Particles Protects Mice against Cryptococcosis in a Manner Dependent upon Mouse Strain and Cryptococcal Species. 
  • Virus-Like Particles Displaying Trimeric Simian Immunodeficiency Virus (SIV) Envelope gp160 Enhance the Breadth of DNA/Modified Vaccinia Virus Ankara SIV Vaccine-Induced Antibody Responses in Rhesus Macaques. 
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  Keywords of People

  • Canelas, Dorian, Associate Professor of the Practice of Chemistry, Chemistry
  • Charles, Hal Cecil, Adjunct Associate Professor in the Department of Radiology, Radiology
  • Katz, David F., Nello L. Teer, Jr. Distinguished Professor of Biomedical Engineering, in the Edmund T. Pratt, Jr. School of Engineering, Biomedical Engineering
  • Klotman, Mary E, R.J. Reynolds Distinguished Professor of Medicine, School of Medicine
  • Olson, Steven Arthur, Goldner Jones Distinguished Professor of Orthopaedic Surgery, Orthopaedic Surgery