Drug Hypersensitivity

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  Subject Areas on Research

  • A genome-wide association study identifies a novel susceptibility locus for the immunogenicity of polyethylene glycol. 
  • A prospective observational study of the effect of penicillin skin testing on antibiotic use in the intensive care unit. 
  • A prospective study of the epidemiology of adverse drug reactions in pediatric hematology and oncology patients. 
  • A randomized study of alglucosidase alfa in late-onset Pompe's disease. 
  • A retrospective analysis of cross-reacting cetuximab IgE antibody and its association with severe infusion reactions. 
  • Acute coronary syndrome antiplatelet alternatives in clopidogrel allergy. 
  • Adverse reactions to protamine. 
  • Allergic reaction to benzophenone. Simultaneous occurrence of urticarial and contact sensitivities. 
  • Allergic reactions during anesthesia. 
  • Allergic reactions to penicillin during in vitro fertilization and intrauterine insemination. 
  • Anaphylactoid reaction due to the administration of ondansetron in a pediatric neurosurgical patient. 
  • Anaphylaxis to meperidine. 
  • Angioedema occurring in patient prescribed iloperidone and haloperidol: a cross-sensitivity reaction to antipsychotics from different chemical classes. 
  • Antibiotic prophylaxis in interventional radiology. 
  • Antibiotic-loaded bone cement for infection prophylaxis in total joint replacement. 
  • Anticoagulation and reversal paradigms: is too much of a good thing bad? 
  • Argatroban for anticoagulation during cardiopulmonary bypass in an infant. 
  • Aspartame and susceptibility to headache. 
  • Aspirin sensitivity does not compromise quality-of-life outcomes in patients with Samter's triad. 
  • Association of genetic variations in HLA-B region with hypersensitivity to abacavir in some, but not all, populations. 
  • Benefits, risk, and uncertainty: preferences of antiretroviral-naïve African Americans for HIV treatments. 
  • Botulinum toxin (Botox) for axillary hyperhidrosis. 
  • Breakthrough adverse reactions to low-osmolar contrast media after steroid premedication. 
  • Bronchopulmonary inflammation and airway smooth muscle hyperresponsiveness induced by nitrogen dioxide in guinea pigs. 
  • Chemotherapy-induced emergencies. 
  • Comparative pharmacokinetic studies of three asparaginase preparations. 
  • Cross-reaction to maprotiline. 
  • Cutaneous clopidogrel hypersensitivity: give steroids and do not stop the clopidogrel. 
  • Desensitization to pancreatic enzyme intolerance in a child with cystic fibrosis. 
  • Diagnosis and treatment of anaphylactic/anaphylactoid reactions. 
  • Direct interaction between HLA-B and carbamazepine activates T cells in patients with Stevens-Johnson syndrome. 
  • Effect of the REG1 anticoagulation system versus bivalirudin on outcomes after percutaneous coronary intervention (REGULATE-PCI): a randomised clinical trial. 
  • Erwinia asparaginase after allergy to E. coli asparaginase in children with acute lymphoblastic leukemia. 
  • Evaluation of dose and schedule of L-asparaginase in multidrug therapy of childhood leukemia. 
  • Evaluation of patients at risk for protamine reactions. 
  • Exposure to topical apraclonidine in children with glaucoma. 
  • Final results of the ReoPro readministration registry. 
  • Fixed-drug eruption due to tetracycline. Report of a case. 
  • Future directions in pharmacogenomics discovery in cardiovascular disease. 
  • Genetic susceptibility to carbamazepine-induced cutaneous adverse drug reactions. 
  • Genetic variations in HLA-B region and hypersensitivity reactions to abacavir. 
  • Genome-wide approaches to identify pharmacogenetic contributions to adverse drug reactions. 
  • Genome-wide association study in NSAID-induced acute urticaria/angioedema in Spanish and Han Chinese populations. 
  • Genome-wide mapping for clinically relevant predictors of lamotrigine- and phenytoin-induced hypersensitivity reactions. 
  • Glatiramer acetate: successful desensitization for treatment of multiple sclerosis. 
  • HLA-A*3101 and carbamazepine-induced hypersensitivity reactions in Europeans. 
  • How accurate is the label "allergic to iodinated contrast agents"? 
  • How well does a history of seafood allergy predict the likelihood of an adverse reaction to i.v. contrast material? 
  • Human leukocyte antigens and drug hypersensitivity. 
  • Hyperendemic Streptococcus pyogenes infection despite prophylaxis with penicillin G benzathine. 
  • Idarucizumab for Dabigatran Reversal - Full Cohort Analysis. 
  • Immunologic reactions to insulin. 
  • In vitro exposure to nitrogen dioxide (NO2) does not alter bronchial smooth muscle responsiveness in ovalbumin-sensitized guinea-pigs. 
  • Incidence and impact on outcome of streptokinase allergy in the GUSTO-I trial. Global Utilization of Streptokinase and t-PA in Occluded Coronary Arteries. 
  • Incidence and predictors of cetuximab hypersensitivity reactions in a North Carolina academic medical center. 
  • Life-threatening reactions to intravenous protamine (I) 
  • Medication Initiation Burden Required to Comply With Heart Failure Guideline Recommendations and Hospital Quality Measures. 
  • Ontogeny of regulatory mechanisms for beta-adrenoceptor control of rat cardiac adenylyl cyclase: targeting of G-proteins and the cyclase catalytic subunit. 
  • Oral erythromycin prophylaxis against Streptococcus pyogenes infection in penicillin-allergic military recruits: a randomized clinical trial. 
  • Paclitaxel for the treatment of progressive or recurrent childhood brain tumors: a pediatric oncology phase II study. 
  • Patient-reported frequency of taking aspirin in a population with coronary artery disease. 
  • Penicillin allergy: A practical guide for clinicians. 
  • Perioperative Anaphylaxis and the United States Perspective 
  • Pharmacogenetics of hypersensitivity to abacavir: from PGx hypothesis to confirmation to clinical utility. 
  • Pharmacogenomics of adverse drug reactions: implementing personalized medicine. 
  • Phase II trial of docetaxel (Taxotere) in metastatic colorectal carcinoma. 
  • Phenytoin hypersensitivity reaction presenting with toxic epidermal necrolysis and severe hepatitis. Report of a patient treated with corticosteroid "pulse therapy". 
  • Phenytoin hypersensitivity. 
  • Polyethylene Glycol-conjugated L-asparaginase versus native L-asparaginase in combination with standard agents for children with acute lymphoblastic leukemia in second bone marrow relapse: a Children's Oncology Group Study (POG 8866). 
  • Practice bulletin no. 123: thromboembolism in pregnancy. 
  • Pre-existing anti-polyethylene glycol antibody linked to first-exposure allergic reactions to pegnivacogin, a PEGylated RNA aptamer. 
  • Prevention and Management of Thromboembolism in Pregnancy When Heparins Are Not an Option. 
  • Rapid Desensitization of the Patients With Aspirin Hypersensitivity and Coronary Artery Disease. 
  • Rate of contrast material extravasations and allergic-like reactions: effect of extrinsic warming of low-osmolality iodinated CT contrast material to 37 degrees C. 
  • Risk factors for development of systemic lupus erythematosus: allergies, infections, and family history. 
  • Risk factors for gram-negative bacterial surgical site infection: do allergies to antibiotics increase risk? 
  • Safety of dapsone as Pneumocystis carinii pneumonia prophylaxis in human immunodeficiency virus-infected patients with allergy to trimethoprim/sulfamethoxazole. 
  • Severe erythroderma as a complication of continuous epoprostenol therapy. 
  • Shared and restricted T-cell receptor use is crucial for carbamazepine-induced Stevens-Johnson syndrome. 
  • Sinusitis: allergies, antibiotics, aspirin, asthma. 
  • Skin rash associated with Sinemet does not equal levodopa allergy. 
  • Successful desensitization to carboplatin in patients with systemic hypersensitivity reactions. 
  • Successful desensitization to oxaliplatin. 
  • Sugammadex hypersensitivity and underlying mechanisms: a randomised study of healthy non-anaesthetised volunteers. 
  • Sulfites in medicines. 
  • Suspected protamine allergy: diagnosis and management for coronary artery surgery. 
  • T-cell receptor and carbamazepine-induced Stevens-Johnson syndrome and toxic epidermal necrolysis: understanding a hypersensitivity reaction. 
  • The Population Reference Sample, POPRES: a resource for population, disease, and pharmacological genetics research. 
  • The medical and economic roles of pipeline pharmacogenetics: Alzheimer's disease as a model of efficacy and HLA-B(*)5701 as a model of safety. 
  • The safe administration of intravenous contrast material for urologists and radiologists. 
  • The use of D-penicillamine in cystinuria: efficacy and untoward reactions. 
  • Treatment of adverse reactions to radiographic contrast media in adults. 
  • Trimethoprim-sulfamethoxazole-induced hepatotoxicity in a pediatric patient. 
  • Type III Hypersensitivity Reaction to Subcutaneous Insulin Preparations in a Type 1 Diabetic. 
  • Urticaria. 
  • Use of Cefazolin for Group B Streptococci Prophylaxis in Women Reporting a Penicillin Allergy Without Anaphylaxis.