Drug Implants

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  Subject Areas on Research

  • Adipogenic and lipolytic effects of chronic glucocorticoid exposure. 
  • Aldosterone Exposure Causes Increased Retinal Edema and Severe Retinopathy Following Laser-Induced Retinal Vein Occlusion in Mice. 
  • An intravitreal device providing sustained release of cyclosporine and dexamethasone. 
  • An intravitreal sustained-release triamcinolone and 5-fluorouracil codrug in the treatment of experimental proliferative vitreoretinopathy. 
  • Androgens and isolation from adult tutors differentially affect the development of songbird neurons critical to vocal plasticity. 
  • Beyond Performance Metrics: Automatic Deep Learning Retinal OCT Analysis Reproduces Clinical Trial Outcome. 
  • Chronic haloperidol administration does not block acute nicotine-induced improvements in radial-arm maze performance in the rat. 
  • Chronic nicotine and withdrawal effects on radial-arm maze performance in rats. 
  • Ciliary neurotrophic factor delivered by encapsulated cell intraocular implants for treatment of geographic atrophy in age-related macular degeneration. 
  • Combined Ahmed Glaucoma Valve Placement, Intravitreal Fluocinolone Acetonide Implantation and Cataract Extraction for Chronic Uveitis. 
  • Combined fluocinolone acetonide intraocular delivery system insertion, phacoemulsification, and intraocular lens implantation for severe uveitis. 
  • Combined fluocinolone acetonide intravitreal insertion and glaucoma drainage device placement for chronic uveitis and glaucoma. 
  • Controlled release of anti-inflammatory agent alpha-MSH from neural implants. 
  • Dexamethasone intravitreal implant in previously treated patients with diabetic macular edema: subgroup analysis of the MEAD study. 
  • Dexamethasone sustained drug delivery implant for the treatment of severe uveitis. 
  • Dislocated ganciclovir implant from use of a nylon fixation suture. 
  • Dissociations of the Fluocinolone Acetonide Implant: The Multicenter Uveitis Steroid Treatment (MUST) Trial and Follow-up Study. 
  • Effect of Ciliary Neurotrophic Factor on Retinal Neurodegeneration in Patients with Macular Telangiectasia Type 2: A Randomized Clinical Trial. 
  • Effect of a Fluocinolone Acetonide Insert on Recurrence Rates in Noninfectious Intermediate, Posterior, or Panuveitis: Three-Year Results. 
  • Effect of an Injectable Fluocinolone Acetonide Insert on Recurrence Rates in Chronic Noninfectious Uveitis Affecting the Posterior Segment: Twelve-Month Results. 
  • Effect of an intravitreal cyclosporine implant on experimental uveitis in horses. 
  • Effect of the duration of macular edema on clinical outcomes in retinal vein occlusion treated with dexamethasone intravitreal implant. 
  • Efficacy of low-release-rate fluocinolone acetonide intravitreal implants to treat experimental uveitis. 
  • Evaluation of a delivery system providing long-term release of cyclosporine. 
  • Factors Predicting Visual Acuity Outcome in Intermediate, Posterior, and Panuveitis: The Multicenter Uveitis Steroid Treatment (MUST) Trial. 
  • Fluocinolone acetonide implant (Retisert) for noninfectious posterior uveitis: thirty-four-week results of a multicenter randomized clinical study. 
  • Fluocinolone acetonide sustained drug delivery device for chronic central retinal vein occlusion: 12-month results. 
  • Fluocinolone acetonide sustained drug delivery device to treat severe uveitis. 
  • Forming a Consensus: Data and Guidance for Physicians Treating Diabetic Macular Edema. 
  • G-protein receptor kinase 3 (GRK3) influences opioid analgesic tolerance but not opioid withdrawal. 
  • Hormonal regulation of male-specific rat hepatic cytochrome P-450g (P-450IIC13) by androgens and the pituitary. 
  • Implantable, polymeric systems for modulated drug delivery. 
  • Implanted estrogen pellets associated with hypertriglyceridemia, biliary dyskinesia and focal nodular hyperplasia of the liver: a case report. 
  • Increased mortality after implantation of first generation drug-eluting stents: seeing the smoke, where is the fire? 
  • Increased rate of peripheral nerve regeneration using bioresorbable nerve guides and a laminin-containing gel. 
  • Inhibition of implant-associated infections via nitric oxide release. 
  • Injectable Fluocinolone Acetonide Long-Acting Implant for Noninfectious Intermediate Uveitis, Posterior Uveitis, and Panuveitis: Two-Year Results. 
  • Intermittent and continuous cocaine administration: residual behavioral states during withdrawal. 
  • Interstitial chemotherapy with drug polymer implants for the treatment of recurrent gliomas. 
  • Intraocular pressure in patients with uveitis treated with fluocinolone acetonide implants. 
  • Intravitreal sustained release corticosteroid-5-fluoruracil conjugate in the treatment of experimental proliferative vitreoretinopathy. 
  • Intravitreal sustained-release cyclosporine in the treatment of experimental uveitis. 
  • Late development of hematoma around a breast implant, necessitating removal. 
  • Leptin therapy in insulin-deficient type I diabetes. 
  • Local administration of L-703,081 using a composite polymeric stent reduces platelet deposition in canine coronary arteries. 
  • Long-term follow-up results of a pilot trial of a fluocinolone acetonide implant to treat posterior uveitis. 
  • MUST Beg to Differ. 
  • Management of tumor bed cysts after chemotherapeutic wafer implantation. Report of four cases. 
  • Managing advanced prostate cancer with Viadur (leuprolide acetate implant). 
  • Modulating antibiotic release from reservoirs in 3D-printed orthopedic devices to treat periprosthetic joint infection. 
  • Mu-opioid receptor desensitization by beta-arrestin-2 determines morphine tolerance but not dependence. 
  • Outcome of Treatment of Uveitic Macular Edema: The Multicenter Uveitis Steroid Treatment Trial 2-Year Results. 
  • Pars plana vitrectomy, fluocinolone acetonide implantation, and silicone oil infusion for the treatment of chronic, refractory uveitic hypotony. 
  • Periocular Triamcinolone vs. Intravitreal Triamcinolone vs. Intravitreal Dexamethasone Implant for the Treatment of Uveitic Macular Edema: The PeriOcular vs. INTravitreal corticosteroids for uveitic macular edema (POINT) Trial. 
  • Pharmacokinetics of the fluocinolone/5-fluorouracil codrug in the gas-filled eye. 
  • Pharmacokinetics of the ganciclovir implant in the silicone-filled eye. 
  • Phase 3, Randomized, 20-Month Study of Bimatoprost Implant in Open-Angle Glaucoma and Ocular Hypertension (ARTEMIS 1). 
  • Phase I study of Gliadel wafers plus temozolomide in adults with recurrent supratentorial high-grade gliomas. 
  • Prospective study of a fluocinolone acetonide implant for chronic macular edema from central retinal vein occlusion: thirty-six-month results. 
  • Prospective trial of gross-total resection with Gliadel wafers followed by early postoperative Gamma Knife radiosurgery and conformal fractionated radiotherapy as the initial treatment for patients with radiographically suspected, newly diagnosed glioblastoma multiforme. 
  • Randomized trial of ciliary neurotrophic factor delivered by encapsulated cell intraocular implants for retinitis pigmentosa. 
  • Reduced foreign body response at nitric oxide-releasing subcutaneous implants. 
  • Reduction of granulosa cell progesterone secretion in vitro by intraovarian implants of antiandrogen. 
  • Regulation of blood vessel versus lymphatic vessel growth in the cornea. 
  • Reimplantation of a fluocinolone acetonide sustained drug delivery implant for chronic uveitis. 
  • Review: implants. 
  • Safety and pharmacokinetics of an intraocular fluocinolone acetonide sustained delivery device. 
  • Site-specific retinoic acid production in the brain of adult songbirds. 
  • Steroid hormones drive cancer development. 
  • Targeted delivery in primary and metastatic brain tumors: summary report of the seventh annual meeting of the Blood-Brain Barrier Disruption Consortium. 
  • The Use of a Novel Antimicrobial Implant Coating In Vivo to Prevent Spinal Implant Infection. 
  • Therapies for Macular Edema Associated with Branch Retinal Vein Occlusion: A Report by the American Academy of Ophthalmology. 
  • Time to disease recurrence in noninfectious uveitis following long-acting injectable fluocinolone acetonide implant. 
  • Timing of onset of contraceptive effectiveness in Norplant implant users. Part I. Changes in cervical mucus. 
  • Treatment of posterior uveitis with a fluocinolone acetonide implant: three-year clinical trial results. 
  • Use of the ganciclovir implant for the treatment of cytomegalovirus retinitis in the era of potent antiretroviral therapy: recommendations of the International AIDS Society-USA panel. 
  • Validation of high gradient magnetic field based drug delivery to magnetizable implants under flow. 
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  Keywords of People

  • McLendon, Roger Edwin, Professor of Pathology, Pathology
  • Muir, Kelly Walton, Associate Professor of Ophthalmology, Ophthalmology, Glaucoma
  • Sampson, John Howard, Robert H., M.D. and Gloria Wilkins Professor of Neurosurgery, in the School of Medicine, Immunology
  • Stinnett, Sandra Sue, Associate Professor of Biostatistics and Bioinformatics, Biostatistics & Bioinformatics