Drug Interactions

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  Subject Areas on Research

  • 5-HT2C Agonists Modulate Schizophrenia-Like Behaviors in Mice. 
  • 9-cis retinoic acid regulation of rat growth hormone gene expression: potential roles of multiple nuclear hormone receptors. 
  • A method for assessing drug therapy appropriateness. 
  • A narrative review of the cardiovascular risks associated with concomitant aspirin and NSAID use. 
  • A nineteen-year-old man with altered mental status. 
  • A peripheral cannabinoid mechanism suppresses spinal fos protein expression and pain behavior in a rat model of inflammation. 
  • A pharmacological study of celecoxib and gemcitabine in patients with advanced pancreatic cancer. 
  • A randomized comparative study to determine the effect of omeprazole on the peak serum concentration of itraconazole oral solution. 
  • A randomized, controlled trial of a clinical pharmacist intervention to improve inappropriate prescribing in elderly outpatients with polypharmacy. 
  • A study of the potential confounding effects of diet, caffeine, nicotine and lorazepam on the stability of plasma and urinary homovanillic acid levels in patients with schizophrenia. 
  • A voltage-gated calcium-selective channel encoded by a sodium channel-like gene. 
  • ACC/AHA expert consensus document. Use of sildenafil (Viagra) in patients with cardiovascular disease. American College of Cardiology/American Heart Association. 
  • ACE inhibitors do not affect erythropoietin efficacy in haemodialysis patients. 
  • Absence of interaction between atorvastatin or other statins and clopidogrel: results from the interaction study. 
  • Acute ethanol administration downregulates human immunodeficiency virus-1 glycoprotein 120-induced KC and RANTES production by murine Kupffer cells and splenocytes. 
  • Acute nicotine interactions with nicotinic and muscarinic antagonists: working and reference memory effects in the 16-arm radial maze. 
  • Addressing Polypharmacy in Older Adults Living With HIV. 
  • Adolescent and adult rats respond differently to nicotine and alcohol: motor activity and body temperature. 
  • Adverse drug events in high risk older outpatients. 
  • Age, dose, and environmental temperature are risk factors for topiramate-related hyperthermia. 
  • Age-related differences in neurosteroid potentiation of muscimol-stimulated 36Cl(-) flux following chronic ethanol treatment. 
  • Aging and cancer. 
  • Alpha-tocopheryl succinate protects hepatocytes from chemical-induced toxicity under physiological calcium conditions. 
  • Alphavirus replicon particles acting as adjuvants promote CD8+ T cell responses to co-delivered antigen. 
  • Alteration of digoxin pharmacokinetics by a single dose of quinidine. 
  • Altered responsiveness to alcohol after exposure to organic lead. 
  • Amphotericin B: 30 years of clinical experience. 
  • Amyloid precursor protein 96-110 and beta-amyloid 1-42 elicit developmental anomalies in sea urchin embryos and larvae that are alleviated by neurotransmitter analogs for acetylcholine, serotonin and cannabinoids. 
  • An approach to the assessment of therapeutic drug interactions with fixed combination drug products. 
  • An exploratory study of the combined effects of orally administered methylphenidate and delta-9-tetrahydrocannabinol (THC) on cardiovascular function, subjective effects, and performance in healthy adults. 
  • An in vitro study of horizontal connections in the intermediate layer of the superior colliculus. 
  • An overview of the clinical rationale for advancing gender-related psychopharmacology and drug abuse research. 
  • Analysis of the risks associated with calcium channel blockade: implications for the obstetrician-gynecologist. 
  • Anidulafungin: a new echinocandin for the treatment of fungal infections. 
  • Antagonist treatment of opioid withdrawal translational low dose approach. 
  • Antagonistic Growth Effects of Mercury and Selenium in Caenorhabditis elegans Are Chemical-Species-Dependent and Do Not Depend on Internal Hg/Se Ratios. 
  • Anti proliferative activity of ELACY (CP-4055) in combination with cloretazine (VNP40101M), idarubicin, gemcitabine, irinotecan and topotecan in human leukemia and lymphoma cells. 
  • Anticoagulation: managing adverse events in patients receiving anticoagulation and perioperative care. 
  • Anticoagulation: monitoring of patients receiving anticoagulation. 
  • Antidepressant therapy in patients with ischemic heart disease. 
  • Antidote-mediated control of an anticoagulant aptamer in vivo. 
  • Antifibrinolytic agents make alpha1- and beta2-microglobulinuria poor markers of postcardiac surgery renal dysfunction. 
  • Antifungal pharmacotherapy for invasive mould infections. 
  • Antiplatelet drug resistance and drug-drug interactions: Role of cytochrome P450 3A4. 
  • Antiplatelet therapy: Clopidogrel-PPI interaction, an ongoing controversy. 
  • Appropriateness of medication prescribing in ambulatory elderly patients. 
  • Aspartate release from rat hippocampal synaptosomes. 
  • Aspirin use and outcomes in a community-based cohort of 7352 patients discharged after first hospitalization for heart failure. 
  • Association between Nephrotoxic Drug Combinations and Acute Kidney Injury in the Neonatal Intensive Care Unit. 
  • Association of adverse drug reactions with drug-drug and drug-disease interactions in frail older outpatients. 
  • Association of diabetes mellitus and glycemic control strategies with clinical outcomes after acute coronary syndromes. 
  • Azithromycin--spectrum of activity, pharmacokinetics, and clinical applications. 
  • Azole antifungals: 35 years of invasive fungal infection management. 
  • Baclofen interactions with nicotine in rats: effects on memory. 
  • Balancing the cyclooxygenase portfolio. 
  • Behavioral alterations in adolescent and adult rats caused by a brief subtoxic exposure to chlorpyrifos during neurulation. 
  • Behavioral and molecular effects of dopamine D1 receptor stimulation during naloxone-precipitated morphine withdrawal. 
  • Benzoate therapy and carnitine deficiency in non-ketotic hyperglycinemia. 
  • Bidirectional interaction of valproate and lamotrigine in healthy subjects. 
  • Biological assessments of a mixture of endocrine disruptors at environmentally relevant concentrations in water following UV/H2O2 oxidation. 
  • Bortezomib sensitizes pancreatic cancer cells to endoplasmic reticulum stress-mediated apoptosis. 
  • Branhamella catarrhalis activates human B lymphocytes following interactions with surface IgD and class I major histocompatibility complex antigens. 
  • Bupropion and guanfacine. 
  • Calcofluor white combination antifungal treatments for Trichophyton rubrum and Candida albicans. 
  • Cancer in People Living With HIV, Version 1.2018, NCCN Clinical Practice Guidelines in Oncology. 
  • Cardiovascular complications of breast cancer therapy in older adults. 
  • Caspofungin: first approved agent in a new class of antifungals. 
  • Cell-enhanced dissolution of carcinogenic lead chromate particles: the role of individual dissolution products in clastogenesis. 
  • Central neurotoxicity after exposure to organic lead: susceptibility to seizures. 
  • Changes in osmolality sensitize the response to capsaicin in trigeminal sensory neurons. 
  • Chlorpyrifos developmental neurotoxicity: interaction with glucocorticoids in PC12 cells. 
  • Chronic myelogenous leukemia. 
  • Chronic nicotine and dizocilpine effects on regionally specific nicotinic and NMDA glutamate receptor binding. 
  • Chronic nicotine interactions with clozapine and risperidone and attentional function in rats. 
  • Chronic nicotine working and reference memory effects in the 16-arm radial maze: interactions with D1 agonist and antagonist drugs. 
  • Circumventing tamoxifen resistance in breast cancers using antiestrogens that induce unique conformational changes in the estrogen receptor. 
  • Clinical consequences of bleeding among individuals with a recent acute coronary syndrome: Insights from the APPRAISE-2 trial. 
  • Clinical outcomes in patients with the concomitant use of clopidogrel and proton pump inhibitors after percutaneous coronary intervention: an analysis from the Guthrie Health Off-Label Stent (GHOST) investigators. 
  • Clopidogrel and PPI interaction: clinically relevant or not? 
  • Clopidogrel and proton pump inhibitors: influence of pharmacological interactions on clinical outcomes and mechanistic explanations. 
  • Clozapine treatment reverses dizocilpine-induced deficits of pre-pulse inhibition of tactile startle response. 
  • Co-medications that modulate liver injury and repair influence clinical outcome of acetaminophen-associated liver injury. 
  • Cocaine self-administration reduces excitatory responses in the mouse nucleus accumbens shell. 
  • Coenzyme Q10 and Heart Failure: A State-of-the-Art Review. 
  • Cognitive function and anticoagulation control in patients with atrial fibrillation. 
  • Combination antifungal therapy. 
  • Combined acetaldehyde and nicotine exposure depresses cardiac contraction in ventricular myocytes: prevention by folic acid. 
  • Combined activity of amphotericin B and 5-fluorocytosine against Cryptococcus neoformans in vitro and in vivo in mice. 
  • Combined effects of dietary phytoestrogen and synthetic endocrine-active compound on reproductive development in Sprague-Dawley rats: genistein and methoxychlor. 
  • Comedications alter drug-induced liver injury reporting frequency: Data mining in the WHO VigiBase™. 
  • Comment: Promethazine adverse events after implementation of a medication shortage interchange. 
  • Common mechanism of toxicity: a case study of organophosphorus pesticides. 
  • Comparison of in vitro and in vivo inhibition potencies of fluvoxamine toward CYP2C19. 
  • Comparison of two knowledge bases on the detection of drug-drug interactions. 
  • Complementary and alternative medicine in cardiovascular disease: a review of biologically based approaches. 
  • Complex drug interactions of HIV protease inhibitors 1: inactivation, induction, and inhibition of cytochrome P450 3A by ritonavir or nelfinavir. 
  • Complex drug interactions of the HIV protease inhibitors 3: effect of simultaneous or staggered dosing of digoxin and ritonavir, nelfinavir, rifampin, or bupropion. 
  • Conflicting results between randomized trials and observational studies on the impact of proton pump inhibitors on cardiovascular events when coadministered with dual antiplatelet therapy: systematic review. 
  • Contribution of itraconazole metabolites to inhibition of CYP3A4 in vivo. 
  • Copper ion-mediated modification of bases in DNA in vitro by benzoyl peroxide. 
  • Critical care perspective on immunotherapy in lung transplantation. 
  • Cyclosporin A inhibits chromium(VI)-induced apoptosis and mitochondrial cytochrome c release and restores clonogenic survival in CHO cells. 
  • Cyclosporine-inhibitable cerebral drug transport does not influence clinical methadone pharmacodynamics. 
  • Cystine-glutamate transport interactions in rat renal cortical tubules, brushborder vesicles, and cultured renal tubule cells. 
  • Cytochrome P4503A does not mediate the interaction between methadone and ritonavir-lopinavir. 
  • D1 and D2 antagonists reverse the effects of appetite suppressants on weight loss, food intake, locomotion, and rebalance spiking inhibition in the rat NAc shell. 
  • D1 and D2 dopamine receptor interactions with pilocarpine-induced oral activity in rats. 
  • Decreased blood-brain barrier permeability to fluorescein in streptozotocin-treated rats. 
  • Depot medroxyprogesterone acetate in combination with a twice-daily lopinavir-ritonavir-based regimen in HIV-infected women showed effective contraception and a lack of clinically significant interactions, with good safety and tolerability: results of the ACTG 5283 study. 
  • Design, implementation and evaluation of a clinical decision support system to prevent adverse drug events. 
  • Desipramine toxicity with terbinafine. 
  • Developmental exposure to an organophosphate flame retardant alters later behavioral responses to dopamine antagonism in zebrafish larvae. 
  • Dialogue with patient care organizations. 
  • Dialysate calcium concentration and the risk of sudden cardiac arrest in hemodialysis patients. 
  • Differential actions of diazepam and zolpidem in basolateral and central amygdala nuclei. 
  • Differential cardiac effects of growth hormone and insulin-like growth factor-1 in the rat. A combined in vivo and in vitro evaluation. 
  • Differential regulation of MeCP2 phosphorylation in the CNS by dopamine and serotonin. 
  • Differential reversal of lipophilic antifolate resistance in mammalian cells with modulators of the multidrug resistance phenotype. 
  • Differentiation of erythroleukemia cells in vitro: properties of chemical inducers. 
  • Does aspirin use adversely influence intermediate-term postdischarge outcomes for hospitalized patients who are treated with angiotensin-converting enzyme inhibitors or angiotensin receptor blockers? Findings from Organized Program to Facilitate Life-Saving Treatment in Hospitalized Patients with Heart Failure (OPTIMIZE-HF). 
  • Dosing recommendations and prescribing patterns for depressed medically ill hospitalized older patients. 
  • Dronedarone and vitamin K antagonists: a review of drug-drug interactions. 
  • Drug interaction between carbapenems and extended-release divalproex sodium in a patient with schizoaffective disorder. 
  • Drug interactions complicate antiplatelet therapy. 
  • Drug interactions: volatile anesthetics and opioids. 
  • Drug-drug interactions in older adults: which ones matter? 
  • Drug-drug-gene interaction risk among opioid users in the U.S. Department of Veterans Affairs. 
  • Drug-induced liver injury: Interactions between drug properties and host factors. 
  • Dystonia as a side effect of nonneuroleptics. 
  • Effect of Azithromycin on Venetoclax Pharmacokinetics in Healthy Volunteers: Implications for Dosing Venetoclax with P-gp Inhibitors. 
  • Effect of Intravenous Fentanyl on Ticagrelor Absorption and Platelet Inhibition Among Patients Undergoing Percutaneous Coronary Intervention: The PACIFY Randomized Clinical Trial (Platelet Aggregation With Ticagrelor Inhibition and Fentanyl). 
  • Effect of Pharmacogenomic Testing for Drug-Gene Interactions on Medication Selection and Remission of Symptoms in Major Depressive Disorder: The PRIME Care Randomized Clinical Trial. 
  • Effect of carbamazepine on Coumadin metabolism. 
  • Effect of colistin on phospholipid-based activated partial thromboplastin time clotting assay results in patients receiving concomitant heparin therapy. 
  • Effect of di(2-ethylhexyl) phthalate on DNA repair and lipid peroxidation in rat hepatocytes and on metabolic cooperation in Chinese hamster V-79 cells. 
  • Effect of low-dose aspirin on thromboxane production and the antihypertensive effect of captopril. 
  • Effect of metabotropic glutamate 5 receptor antagonists on morphine efficacy and tolerance in rats with neuropathic pain. 
  • Effect of rifampicin on S-ketamine and S-norketamine plasma concentrations in healthy volunteers after intravenous S-ketamine administration. 
  • Effect of ritonavir-induced cytochrome P450 3A4 inhibition on plasma fentanyl concentrations during patient-controlled epidural labor analgesia: a pharmacokinetic simulation. 
  • Effect of simultaneous didanosine administration on itraconazole absorption in healthy volunteers. 
  • Effects of ZD6169, a K ATP channel opener, on neurally-mediated plasma extravasation in the rat urinary bladder induced by chemical or electrical stimulation of nerves. 
  • Effects of beta-endorphin on ornithine decarboxylase in tissues of developing rats: a potential role for this endogenous neuropeptide in the modulation of tissue growth. 
  • Effects of daily dermal application of DEET and epermethrin, alone and in combination, on sensorimotor performance, blood-brain barrier, and blood-testis barrier in rats. 
  • Effects of dopamine D1 and D2 receptor antagonists on oral activity in rats. 
  • Effects of gamma hydroxybutyric acid on inhibition and excitation in rat neocortex. 
  • Effects of glutathione on chromium-induced DNA crosslinking and DNA polymerase arrest. 
  • Effects of reserpine on the content and properties of rat adrenal medullary storage vesicles. 
  • Effects of sazetidine-A, a selective α4β2* nicotinic receptor desensitizing agent, on body temperature regulation in mice and rats. 
  • Effects of single and combined exposures to benzo(a)pyrene and 3,3'4,4'5-pentachlorobiphenyl on EROD activity and development in Fundulus heteroclitus. 
  • Effects of sofosbuvir-based hepatitis C treatment on the pharmacokinetics of tenofovir in HIV/HCV-coinfected individuals receiving tenofovir disoproxil fumarate. 
  • Effects of the polycyclic aromatic hydrocarbon heterocycles, carbazole and dibenzothiophene, on in vivo and in vitro CYP1A activity and polycyclic aromatic hydrocarbon-derived embryonic deformities. 
  • Effects of tobacco smoking and nicotine on cancer treatment. 
  • Efficacy and safety of St. John's wort for the treatment of major depression. 
  • Efficacy and safety of angiotensin receptor blockade are not modified by aspirin in patients with chronic heart failure: a cohort study from the Candesartan in Heart failure--Assessment of Reduction in Mortality and morbidity (CHARM) programme. 
  • Elevated mu-opioid receptor expression in the nucleus of the solitary tract accompanies attenuated withdrawal signs after chronic low dose naltrexone in opiate-dependent rats. 
  • Emodin induces apoptosis in human promyeloleukemic HL-60 cells accompanied by activation of caspase 3 cascade but independent of reactive oxygen species production. 
  • Enfuvirtide: the first therapy to inhibit the entry of HIV-1 into host CD4 lymphocytes. 
  • Enhancement of irinotecan (CPT-11) activity against central nervous system tumor xenografts by alkylating agents. 
  • Epidemiology of drug-disease interactions in older veteran nursing home residents. 
  • Establishment of a melphalan-resistant rhabdomyosarcoma xenograft with cross-resistance to vincristine and enhanced sensitivity following buthionine sulfoximine-mediated glutathione depletion. 
  • Estradiol replacement enhances cocaine-stimulated locomotion in female C57BL/6 mice through estrogen receptor alpha. 
  • Ethanol and magnesium ions inhibit N-methyl-D-aspartate-mediated synaptic potentials in an interactive manner. 
  • Evaluation of the dofetilide risk-management program. 
  • Evaluation of the pharmacokinetic drug interaction potential of tivantinib (ARQ 197) using cocktail probes in patients with advanced solid tumours. 
  • Exercise biology and medicine: innovative research to improve global health. 
  • Extended Oral Antibiotics and Infection Prophylaxis after a Primary or Revision Total Knee Arthroplasty. 
  • Facilitation of granule cell epileptiform activity by mossy fiber-released zinc in the pilocarpine model of temporal lobe epilepsy. 
  • Fast endocytosis is inhibited by GABA-mediated chloride influx at a presynaptic terminal. 
  • Flunarizine enhancement of melphalan activity against drug-sensitive/resistant rhabdomyosarcoma. 
  • Fluvoxamine-theophylline interaction: gap between in vitro and in vivo inhibition constants toward cytochrome P4501A2. 
  • Frequency of high-risk use of QT-prolonging medications. 
  • GSNO reductase and beta2-adrenergic receptor gene-gene interaction: bronchodilator responsiveness to albuterol. 
  • Guidance on the emergent reversal of oral thrombin and factor Xa inhibitors. 
  • Guidelines for the diagnosis and treatment of non-ST-segment elevation acute coronary syndromes. 
  • Heparinase I (neutralase) reversal of systemic anticoagulation. 
  • Histamine H1 receptor involvement in prepulse inhibition and memory function: relevance for the antipsychotic actions of clozapine. 
  • How important are drug-drug interactions to the health of older adults? 
  • How to manage drug interactions. 
  • Ibrutinib: a new targeted therapy for hematologic cancers. 
  • Imbalances emerge in cardiac autonomic cell signaling after neonatal exposure to terbutaline or chlorpyrifos, alone or in combination. 
  • Immediate and delayed neurotoxicity after mechlorethamine preparation for bone marrow transplantation. 
  • Immunostimulatory properties of genomic DNA from different bacterial species. 
  • Impact of Polypharmacy and P-Glycoprotein- and CYP3A4-Modulating Drugs on Safety and Efficacy of Oral Anticoagulation Therapy in Patients with Atrial Fibrillation. 
  • Impact of inappropriate drug use on health services utilization among representative older community-dwelling residents. 
  • Impact of morphine on antiplatelet effects of oral P2Y12 receptor inhibitors. 
  • Impact of prophylactic oseltamivir on INR in patients on stable warfarin therapy. 
  • Importance of potent P2Y(12) receptor blockade in acute myocardial infarction: focus on prasugrel. 
  • Improving neutralization potency and breadth by combining broadly reactive HIV-1 antibodies targeting major neutralization epitopes. 
  • In vitro interactions between antifungals and immunosuppressants against Aspergillus fumigatus. 
  • Incidence and predictors of all and preventable adverse drug reactions in frail elderly persons after hospital stay. 
  • Incidence of Drug Interactions Identified by Clinical Pharmacists in Veterans Initiating Treatment for Chronic Hepatitis C Infection. 
  • Incidence of caffeine in serum of patients undergoing dipyridamole myocardial perfusion stress test by an intensive versus routine caffeine history screening. 
  • Increased melphalan activity in intracranial human medulloblastoma and glioma xenografts following buthionine sulfoximine-mediated glutathione depletion. 
  • Individual Proton Pump Inhibitors and Outcomes in Patients With Coronary Artery Disease on Dual Antiplatelet Therapy: A Systematic Review. 
  • Induction of urinary excretion of 3-nitrotyrosine, a marker of oxidative stress, following administration of pyridostigmine bromide, DEET (N,N-diethyl-m-toluamide) and permethrin, alone and in combination in rats. 
  • Infection and cyclosporine. 
  • Influence of HIV antiretrovirals on methadone N-demethylation and transport. 
  • Influence of Successful Chronic Hepatitis C Virus Treatment with Ledipasvir/Sofosbuvir on Warfarin Dosing Requirements in Four Veterans. 
  • Influence of hepatic and intestinal cytochrome P4503A activity on the acute disposition and effects of oral transmucosal fentanyl citrate. 
  • Interacting medication use and the treatment effects of apixaban versus warfarin: results from the ARISTOTLE Trial. 
  • Interaction between digoxin and dronedarone in the PALLAS trial. 
  • Interaction between marihuana and ethanol: effects on psychomotor performance. 
  • Interaction of endosulfan and dietary vitamin A on rat hepatic drug metabolising enzymes. 
  • Interaction of vitamin A and cortisol on liver and plasma lipids of rats. 
  • Interactions between heparins, glycoprotein IIb/IIIa antagonists, and coronary intervention. The Global Registry of Acute Coronary Events (GRACE). 
  • Interactions between highly active antiretroviral therapy and over-the-counter agents: a cautionary note. 
  • Interactions of vasoactive intestinal polypeptide and cholecystokinin octapeptide on the control of gallbladder contraction. 
  • Is bleeding a necessary evil? The inherent risk of antithrombotic pharmacotherapy used for stroke prevention in atrial fibrillation. 
  • Isoflurane alters the kinetics of oral cyclosporine. 
  • Isoproterenol inhibits the increase in microvascular membrane permeability produced by bradykinin. 
  • Ketanserin attenuates nicotine-induced working memory improvement in rats. 
  • Lack of indinavir effects on methadone disposition despite inhibition of hepatic and intestinal cytochrome P4503A (CYP3A). 
  • Lactogenic and somatogenic hormones regulate the expression of neuropeptide Y and cocaine- and amphetamine-regulated transcript in rat insulinoma (INS-1) cells: interactions with glucose and glucocorticoids. 
  • Leptin mediates the parathyroid hormone-related protein paracrine stimulation of fetal lung maturation. 
  • Leptin opposes insulin's effects on fatty acid partitioning in muscles isolated from obese ob/ob mice. 
  • Leveraging Physiologically Based Pharmacokinetic Modeling and Experimental Data to Guide Dosing Modification of CYP3A-Mediated Drug-Drug Interactions in the Pediatric Population. 
  • Locomotor and sensorimotor performance deficit in rats following exposure to pyridostigmine bromide, DEET, and permethrin, alone and in combination. 
  • Lovastatin and coadministered antihypertensive/cardiovascular agents. 
  • Machine Learning Uncovers Food- and Excipient-Drug Interactions. 
  • Magnesium sulfate inhibits the oxytocin-induced production of inositol 1,4,5-trisphosphate in cultured human myometrial cells. 
  • Magnitude and ethanol sensitivity of tonic GABAA receptor-mediated inhibition in dentate gyrus changes from adolescence to adulthood. 
  • Management of drug and food interactions with azole antifungal agents in transplant recipients. 
  • Management of patients coinfected with HCV and HIV: a close look at the role for direct-acting antivirals. 
  • Management of platelet-directed pharmacotherapy in patients with atherosclerotic coronary artery disease undergoing elective endoscopic gastrointestinal procedures. 
  • Marijuana Use in the Anesthetized Patient: History, Pharmacology, and Anesthetic Considerations. 
  • Maternal cadmium, iron and zinc levels, DNA methylation and birth weight. 
  • Mathematical modeling of cell metabolism 
  • Mechanism of efavirenz influence on methadone pharmacokinetics and pharmacodynamics. 
  • Mechanism of ritonavir changes in methadone pharmacokinetics and pharmacodynamics: I. Evidence against CYP3A mediation of methadone clearance. 
  • Mechanism of ritonavir changes in methadone pharmacokinetics and pharmacodynamics: II. Ritonavir effects on CYP3A and P-glycoprotein activities. 
  • Medical management of adrenal cortical disease. 
  • Metabolism of dapsone to its hydroxylamine by CYP2E1 in vitro and in vivo. 
  • Metformin Use May Moderate the Effect of DPP-4 Inhibitors on Cardiovascular Outcomes. 
  • Methadone Disposition: Implementing Lessons Learned. 
  • Methadone pharmacokinetics are independent of cytochrome P4503A (CYP3A) activity and gastrointestinal drug transport: insights from methadone interactions with ritonavir/indinavir. 
  • Milnacipran: beyond a role of antidepressant. 
  • Mitogenesis, cell migration, and loss of focal adhesions induced by tenascin-C interacting with its cell surface receptor, annexin II. 
  • Mitomycin C and menadione for the treatment of lung cancer: a phase II trial. 
  • Modeling the developmental neurotoxicity of nicotine in vitro: cell acquisition, growth and viability in PC12 cells. 
  • Modulating role of lithium on dopamine turnover, prolactin release, and behavioral supersensitivity following haloperidol and reserpine. 
  • Modulation of ATP-induced calcium signaling by progesterone in T47D-Y breast cancer cells. 
  • Multifactorial optimization of endothelial cell growth using modular synthetic extracellular matrices. 
  • Muscarinic inhibition of substance P induced ion secretion in piglet jejunum. 
  • N-acetylcysteine does not modify nitroglycerin-induced tolerance in canine vascular rings. 
  • NMDA receptor antagonists ameliorate the stepping deficits produced by unilateral medial forebrain bundle injections of 6-OHDA in rats. 
  • National Academy of Clinical Biochemistry Laboratory Medicine practice guidelines: Clinical utilization of cardiac biomarker testing in heart failure. 
  • Neuregulin-1 enhances depolarization-induced GABA release. 
  • Neurosteroid modulation of GABAergic neurotransmission in the central amygdala: a role for NMDA receptors. 
  • Neurotensin reduces glutamatergic transmission in the dorsolateral striatum via retrograde endocannabinoid signaling. 
  • Nicotine inhibits voltage-dependent sodium channels and sensitizes vanilloid receptors. 
  • Nicotine interactions with haloperidol, clozapine and risperidone and working memory function in rats. 
  • Nicotine interactions with low-dose alcohol: pharmacological influences on smoking and drinking motivation. 
  • Nicotine-alcohol interactions and attentional performance on an operant visual signal detection task in female rats. 
  • Nicotine-antipsychotic drug interactions and attentional performance in female rats. 
  • Nicotine-dizocilpine interactions and working and reference memory performance of rats in the radial-arm maze. 
  • Nicotinic and muscarinic interactions and choice accuracy in the radial-arm maze. 
  • Nicotinic antagonist effects in the mediodorsal thalamic nucleus: regional heterogeneity of nicotinic receptor involvement in cognitive function. 
  • Nicotinic interactions with antipsychotic drugs, models of schizophrenia and impacts on cognitive function. 
  • Nicotinic-antipsychotic drug interactions and cognitive function. 
  • Nicotinic-glutamatergic interactions and attentional performance on an operant visual signal detection task in female rats. 
  • Nicotinic-serotonergic drug interactions and attentional performance in rats. 
  • Ofloxacin: its pharmacology, pharmacokinetics, and potential for clinical application. 
  • Olanzapine interactions with nicotine and mecamylamine in rats: effects on memory function. 
  • Opposite effects of lead on chemical carcinogenesis in kidney and liver of rats. 
  • Oral activated charcoal prevents experimental cerebral malaria in mice and in a randomized controlled clinical trial in man did not interfere with the pharmacokinetics of parenteral artesunate. 
  • Oral anticoagulants for stroke prevention in atrial fibrillation: current status, special situations, and unmet needs. 
  • Oral anticoagulants in older adults with atrial fibrillation. 
  • Oral poly(ADP-ribose) polymerase-1 inhibitor BSI-401 has antitumor activity and synergizes with oxaliplatin against pancreatic cancer, preventing acute neurotoxicity. 
  • Oxidative mechanisms contributing to the developmental neurotoxicity of nicotine and chlorpyrifos. 
  • PA tablets: investigational compounds combining aspirin and omeprazole for cardioprotection. 
  • PI3 kinase is involved in cocaine behavioral sensitization and its reversal with brain area specificity. 
  • Paradoxical intraocular pressure elevation after combined therapy with latanoprost and bimatoprost. 
  • Paroxetine: safety and tolerability issues. 
  • Perfluorooctyl bromide (perflubron) attenuates oxidative injury to biological and nonbiological systems. 
  • Pergolide interactions with nicotine and pilocarpine in rats on the radial-arm maze. 
  • Periischemic cerebral blood flow (CBF) does not explain beneficial effects of isoflurane on outcome from near-complete forebrain ischemia in rats. 
  • Pharmacodynamic evaluation of clopidogrel plus PA32540: the Spaced PA32540 With Clopidogrel Interaction Gauging (SPACING) study. 
  • Pharmacogenomics for personalized pain medicine. 
  • Pharmacokinetic interactions and safety evaluations of coadministered tafenoquine and chloroquine in healthy subjects. 
  • Pharmacokinetic interactions between buprenorphine and antiretroviral medications. 
  • Pharmacokinetics and pharmacodynamics of ticagrelor in patients with stable coronary artery disease: results from the ONSET-OFFSET and RESPOND studies. 
  • Pharmacokinetics of levetiracetam. 
  • Phase I study of SU5416, a small molecule inhibitor of the vascular endothelial growth factor receptor (VEGFR) in refractory pediatric central nervous system tumors. 
  • Phase I trial of interleukin-2 plus doxorubicin. 
  • Phase I/II study of the P-glycoprotein modulator PSC 833 in patients with acute myeloid leukemia. 
  • Phenamil: an irreversible inhibitor of sodium channels in the toad urinary bladder. 
  • Physiologically-Based Pharmacokinetic Modeling Characterizes the CYP3A-Mediated Drug-Drug Interaction Between Fluconazole and Sildenafil in Infants. 
  • Polyamines antagonize N-methyl-D-aspartate-evoked depolarizations, but reduce Mg2+ block. 
  • Polypharmacy management in Medicare managed care: changes in prescribing by primary care physicians resulting from a program promoting medication reviews. 
  • Posaconazole's impact on prophylaxis and treatment of invasive fungal infections: an update. 
  • Postsynaptic mechanisms govern the differential excitation of cortical neurons by thalamic inputs. 
  • Postsynaptic requirement for Abl kinases in assembly of the neuromuscular junction. 
  • Potency of combined estrogenic pesticides. 
  • Potential interactions between GABAb and cholinergic systems: baclofen augments scopolamine-induced performance deficits in the eight-arm radial maze. 
  • Potential kidney toxicity from the antiviral drug tenofovir: new indications, new formulations, and a new prodrug. 
  • Practical aspects of MAO inhibitor therapy. 
  • Preclinical evaluation of gemcitabine combination regimens for application in acute myeloid leukemia. 
  • Prediction in drug abuse: cocaine interactions with alcohol and buprenorphine. 
  • Prenatal nicotine changes the response to postnatal chlorpyrifos: Interactions targeting serotonergic synaptic function and cognition. 
  • Psychopharmacological interactions between nicotine and ethanol. 
  • Psychophysiological interactions between caffeine and nicotine. 
  • Psychotherapeutic agents in older adults. Metabolism, bioavailability, and drug interactions. 
  • Pyrimethamine pharmacokinetics in human immunodeficiency virus-positive patients seropositive for Toxoplasma gondii. 
  • Quality of pharmacotherapy and outcomes for older veterans discharged from the emergency department. 
  • Quenching of DNA cross-link precursors of chloroethylnitrosoureas and attenuation of DNA interstrand cross-linking by glutathione. 
  • Quinidine as a probe for the role of p-glycoprotein in the intestinal absorption and clinical effects of fentanyl. 
  • Radial-arm maze performance in rats is impaired by a combination of nicotinic-cholinergic and D2 dopaminergic antagonist drugs. 
  • Randomized comparison of direct thrombin inhibition versus heparin in conjunction with fibrinolytic therapy for acute myocardial infarction: results from the GUSTO-IIb Trial. Global Use of Strategies to Open Occluded Coronary Arteries in Acute Coronary Syndromes (GUSTO-IIb) Investigators. 
  • Rational theophylline use in older asthmatics. 
  • Real-world implications of QT prolongation in patients receiving voriconazole and amiodarone. 
  • Reboxetine: a selective norepinephrine reuptake inhibitor for the treatment of depression. 
  • Reducing polypharmacy: evidence from a simple quality improvement initiative. 
  • Regulation of beta adrenergic receptors in isolated frog erythrocyte plasma membranes. 
  • Relationship between dietary retinol and lipofuscin in the retinal pigment epithelium. 
  • Reliability of a modified medication appropriateness index in ambulatory older persons. 
  • Research Priorities to Advance the Health and Health Care of Older Adults with Multiple Chronic Conditions. 
  • Restorative effects of GDNF on striatal dopamine release in rats treated with neurotoxic doses of methamphetamine. 
  • Reversal of a mecamylamine-induced cognitive deficit with the D2 agonist, LY 171555. 
  • Reversal of physiological stress-induced resistance to topoisomerase II inhibitors using an inducible phosphorylation site-deficient mutant of I kappa B alpha. 
  • Risk of major bleeding with concomitant dual antiplatelet therapy after percutaneous coronary intervention in patients receiving long-term warfarin therapy. 
  • Role of C-terminal serines in desensitization and phosphorylation of the mouse thromboxane receptor. 
  • Role of P-glycoprotein in the intestinal absorption and clinical effects of morphine. 
  • Role of the GLT-1 subtype of glutamate transporter in glutamate homeostasis: the GLT-1-preferring inhibitor WAY-855 produces marginal neurotoxicity in the rat hippocampus. 
  • Roundtable panel discussion: the role of glycoprotein IIb-IIIa receptor inhibitors in acute ischemic coronary syndromes. 
  • Safety considerations in the use of drug combinations during general anaesthesia. 
  • Safety events in kidney transplant recipients: results from the folic Acid for vascular outcome reduction in transplant trial. 
  • Safety of aprotinin in heparinized and nonheparinized patients. 
  • Sazetidine-A, a selective α4β2 nicotinic acetylcholine receptor ligand: effects on dizocilpine and scopolamine-induced attentional impairments in female Sprague-Dawley rats. 
  • Schizophrenia, drug therapy, and monitoring. 
  • Selective activation of cannabinoid CB(2) receptors suppresses spinal fos protein expression and pain behavior in a rat model of inflammation. 
  • Sensorimotor deficit and cholinergic changes following coexposure with pyridostigmine bromide and sarin in rats. 
  • Sensorimotor deficits and increased brain nicotinic acetylcholine receptors following exposure to chlorpyrifos and/or nicotine in rats. 
  • Serotonin syndrome in a chronic-pain patient receiving concurrent methadone, ciprofloxacin, and venlafaxine. 
  • Serotonin-lesion myoclonic syndromes. I. Neurochemical profile and S-1 receptor binding. 
  • Sex-related differences in clinical drug response: Implications for women's health 
  • Sex-related spatial learning differences after prenatal cocaine exposure in the young adult rat. 
  • Silver ions increase auxin efflux independently of effects on ethylene response. 
  • Simultaneous assessment of drug interactions with low- and high-extraction opioids: application to parecoxib effects on the pharmacokinetics and pharmacodynamics of fentanyl and alfentanil. 
  • Simultaneous determination of alfentanil and midazolam in human plasma using liquid chromatography and tandem mass spectrometry. 
  • Single-dose disulfiram inhibition of chlorzoxazone metabolism: a clinical probe for P450 2E1. 
  • Single-point sampling for assessment of constitutive, induced, and inhibited cytochrome P450 3A activity with alfentanil or midazolam. 
  • Specific functions of synaptically localized potassium channels in synaptic transmission at the neocortical GABAergic fast-spiking cell synapse. 
  • Statin Safety and Associated Adverse Events: A Scientific Statement From the American Heart Association. 
  • Statin therapy--Part II: Clinical considerations for cardiovascular disease. 
  • Statins do not affect platelet inhibition with clopidogrel during coronary stenting. 
  • Stereoselective bupropion hydroxylation as an in vivo phenotypic probe for cytochrome P4502B6 (CYP2B6) activity. 
  • Subacute ethanol consumption reverses p-xylene-induced decreases in axonal transport. 
  • Suboptimal prescribing in older inpatients and outpatients. 
  • Survey of methadone-drug interactions among patients of methadone maintenance treatment program in Taiwan. 
  • Susceptibility of Aspergillus to 5-fluorocytosine and amphotericin B alone and in combination. 
  • Swainsonine protects both murine and human haematopoietic systems from chemotherapeutic toxicity. 
  • Symposium overview: mechanism of action of nicotine on neuronal acetylcholine receptors, from molecule to behavior. 
  • Symptom exacerbation in psychotically depressed adolescents due to high desipramine plasma concentrations. 
  • Synergistic embryotoxicity of polycyclic aromatic hydrocarbon aryl hydrocarbon receptor agonists with cytochrome P4501A inhibitors in Fundulus heteroclitus. 
  • Tamoxifen pharmacogenomics: the role of CYP2D6 as a predictor of drug response. 
  • The Ca(2+) channel antagonists mibefradil and pimozide inhibit cell growth via different cytotoxic mechanisms. 
  • The anticoagulated patient: strategies for effective blood loss management. 
  • The clinical management of HCV in the HIV-infected patient. 
  • The clinical pharmacogenetics implementation consortium guideline for SLCO1B1 and simvastatin-induced myopathy: 2014 update. 
  • The clopidogrel-statin interaction. 
  • The convergence of herb pharmacodynamics and herb-drug interactions on hemostasis. 
  • The drug-drug interaction between proton pump inhibitors and clopidogrel. 
  • The effect of active site-inhibited factor VIIa on tissue factor-initiated coagulation using platelets before and after aspirin administration. 
  • The effect of antibiotic additions on the mechanical properties of acrylic cement. 
  • The effect of aprepitant and race on the pharmacokinetics of cyclophosphamide in breast cancer patients. 
  • The effect of endothelin-1 on muscle microcirculation and its attenuation by verapamil. 
  • The effect of quinidine, propranolol and their combination on experimental atrial and ventricular arrhythmias. 
  • The effect of the interaction of propofol and alfentanil on recall, loss of consciousness, and the Bispectral Index. 
  • The effects of MDCO-2010, a serine protease inhibitor, on activated clotting time in blood obtained from volunteers and cardiac surgical patients. 
  • The influence of drug properties and host factors on delayed onset of symptoms in drug-induced liver injury. 
  • The interplay of prolactin and the glucocorticoids in the regulation of beta-cell gene expression, fatty acid oxidation, and glucose-stimulated insulin secretion: implications for carbohydrate metabolism in pregnancy. 
  • The microtubule interacting drug candidate NAP protects against kainic acid toxicity in a rat model of epilepsy. 
  • The newer antiepileptic drugs: carbamazepine and valproic acid. 
  • The non-covalent interaction of pyrrolo[2, 1-c] [1, 4]benzodiazepine-5, 11-diones with DNA. 
  • The novel combination of theophylline and bambuterol as a potential treatment of hypoxemia in humans. 
  • The pharmacokinetics of timegadine and two of its metabolites after multiple oral dosing, and the effects of concomitant administration of ibuprofen. 
  • The quality of pharmacotherapy in older veterans discharged from the emergency department or urgent care clinic. 
  • The relation of quinidine-induced elevation of serum digoxin concentration to the conversion of atrial fibrillation-flutter: a pilot study. 
  • The response to inhaled nitric oxide in patients with pulmonary artery hypertension is not masked by baseline vasodilator use. 
  • The role of alpha7 and alpha4beta2 nicotinic receptors in the nicotine-induced anxiolytic effect in zebrafish. 
  • The role of cytochrome P450 3A4 in alfentanil clearance. Implications for interindividual variability in disposition and perioperative drug interactions. 
  • The sea urchin embryo, an invertebrate model for mammalian developmental neurotoxicity, reveals multiple neurotransmitter mechanisms for effects of chlorpyrifos: therapeutic interventions and a comparison with the monoamine depleter, reserpine. 
  • The vulnerable endothelium: priming the vascular endothelium for thrombosis with unfractionated heparin: biologic plausibility for observations from the Superior Yield of the New Strategy of Enoxaparin, Revascularization and GlYcoprotein IIb/IIIa Inhibitors (SYNERGY) trial. 
  • The α₂-adrenergic antagonist idazoxan counteracts prepulse inhibition deficits caused by amphetamine or dizocilpine in rats. 
  • Thrombin enhances monocyte secretion of tumor necrosis factor and interleukin-1 beta by two distinct mechanisms. 
  • Thrombomodulin increases the rate of thrombin inhibition by BPTI. 
  • Tolvaptan administration does not affect steady state amiodarone concentrations in patients with cardiac arrhythmias. 
  • Transient increase in plasma quinidine concentrations during ketoconazole-quinidine therapy. 
  • Transiently overexpressed alpha2-adrenoceptors and their control of DNA synthesis in the developing brain. 
  • Treatment considerations for patients with neuropathic pain and other medical comorbidities. 
  • Treatment options for invasive fungal infections. 
  • Tricyclic-induced akathisia in patients taking conjugated estrogens. 
  • Understanding therapeutic equivalence in epilepsy. 
  • Usability of mobile technology to screen for drug-drug interactions in kidney transplant patients. 
  • Use of control steady-state serum digoxin levels for predicting serum digoxin concentration after quinidine administration. 
  • Use of sildenafil (Viagra) in patients with cardiovascular disease. Technology and Practice Executive Committee. 
  • Vasodilator administration in the presence of beta-adrenergic blockade. 
  • Ventral hippocampal NMDA blockade and nicotinic effects on memory function. 
  • Ventral hippocampal ibotenic acid lesions block chronic nicotine-induced spatial working memory improvement in rats. 
  • Virologic failure in therapy-naive subjects on aplaviroc plus lopinavir-ritonavir: detection of aplaviroc resistance requires clonal analysis of envelope. 
  • Warfarin and acetaminophen interaction: a summary of the evidence and biologic plausibility. 
  • Warfarin reversal with prothrombin complex concentrate confers better antifibrinolytic activity compared with recombinant activated factor VII. 
  • What clinicians should know about the QT interval. 
  • What is the role of combination drug therapy in the treatment of overactive bladder? ICI-RS 2014. 
  • rHuEPO and improved treatment outcomes: potential modes of action. 
  • tPA-mediated generation of plasmin is catalyzed by the proteoglycan NG2. 
• 

  Keywords of People

  • Curtis, Lesley H., Professor in Population Health Sciences, Medicine, General Internal Medicine
  • Erickson, Harold Paul, Professor Emeritus of Cell Biology, Cell Biology
  • Freemark, Michael Scott, Robert C. Atkins, M.D. and Veronica Atkins Distinguished Professor of Pediatrics, in the School of Medicine, Pediatrics, Endocrinology
  • McDonnell, Donald Patrick, Glaxo-Wellcome Distinguished Professor of Molecular Cancer Biology, in the School of Medicine, Cell Biology
  • Middleton, John Paul, Professor of Medicine, Medicine, Nephrology
  • O'Connor, Christopher Michael, Richard Sean Stack, M.D. Distinguished Professor, Medicine, Clinical Pharmacology
  • Wu, Li-Tzy, Professor in Psychiatry and Behavioral Sciences, Medicine, General Internal Medicine