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Subject Areas on Research
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5-HT2C Agonists Modulate Schizophrenia-Like Behaviors in Mice.
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9-cis retinoic acid regulation of rat growth hormone gene expression: potential roles of multiple nuclear hormone receptors.
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A method for assessing drug therapy appropriateness.
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A narrative review of the cardiovascular risks associated with concomitant aspirin and NSAID use.
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A nineteen-year-old man with altered mental status.
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A peripheral cannabinoid mechanism suppresses spinal fos protein expression and pain behavior in a rat model of inflammation.
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A pharmacological study of celecoxib and gemcitabine in patients with advanced pancreatic cancer.
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A randomized comparative study to determine the effect of omeprazole on the peak serum concentration of itraconazole oral solution.
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A randomized, controlled trial of a clinical pharmacist intervention to improve inappropriate prescribing in elderly outpatients with polypharmacy.
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A study of the potential confounding effects of diet, caffeine, nicotine and lorazepam on the stability of plasma and urinary homovanillic acid levels in patients with schizophrenia.
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A voltage-gated calcium-selective channel encoded by a sodium channel-like gene.
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ACC/AHA expert consensus document. Use of sildenafil (Viagra) in patients with cardiovascular disease. American College of Cardiology/American Heart Association.
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ACE inhibitors do not affect erythropoietin efficacy in haemodialysis patients.
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Absence of interaction between atorvastatin or other statins and clopidogrel: results from the interaction study.
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Acute ethanol administration downregulates human immunodeficiency virus-1 glycoprotein 120-induced KC and RANTES production by murine Kupffer cells and splenocytes.
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Acute nicotine interactions with nicotinic and muscarinic antagonists: working and reference memory effects in the 16-arm radial maze.
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Addressing Polypharmacy in Older Adults Living With HIV.
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Adolescent and adult rats respond differently to nicotine and alcohol: motor activity and body temperature.
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Adverse drug events in high risk older outpatients.
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Age, dose, and environmental temperature are risk factors for topiramate-related hyperthermia.
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Age-related differences in neurosteroid potentiation of muscimol-stimulated 36Cl(-) flux following chronic ethanol treatment.
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Aging and cancer.
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Alpha-tocopheryl succinate protects hepatocytes from chemical-induced toxicity under physiological calcium conditions.
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Alphavirus replicon particles acting as adjuvants promote CD8+ T cell responses to co-delivered antigen.
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Alteration of digoxin pharmacokinetics by a single dose of quinidine.
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Altered responsiveness to alcohol after exposure to organic lead.
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Amphotericin B: 30 years of clinical experience.
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Amyloid precursor protein 96-110 and beta-amyloid 1-42 elicit developmental anomalies in sea urchin embryos and larvae that are alleviated by neurotransmitter analogs for acetylcholine, serotonin and cannabinoids.
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An approach to the assessment of therapeutic drug interactions with fixed combination drug products.
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An exploratory study of the combined effects of orally administered methylphenidate and delta-9-tetrahydrocannabinol (THC) on cardiovascular function, subjective effects, and performance in healthy adults.
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An in vitro study of horizontal connections in the intermediate layer of the superior colliculus.
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An overview of the clinical rationale for advancing gender-related psychopharmacology and drug abuse research.
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Analysis of the risks associated with calcium channel blockade: implications for the obstetrician-gynecologist.
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Anidulafungin: a new echinocandin for the treatment of fungal infections.
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Antagonist treatment of opioid withdrawal translational low dose approach.
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Antagonistic Growth Effects of Mercury and Selenium in Caenorhabditis elegans Are Chemical-Species-Dependent and Do Not Depend on Internal Hg/Se Ratios.
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Anti proliferative activity of ELACY (CP-4055) in combination with cloretazine (VNP40101M), idarubicin, gemcitabine, irinotecan and topotecan in human leukemia and lymphoma cells.
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Anticoagulation: managing adverse events in patients receiving anticoagulation and perioperative care.
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Anticoagulation: monitoring of patients receiving anticoagulation.
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Antidepressant therapy in patients with ischemic heart disease.
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Antidote-mediated control of an anticoagulant aptamer in vivo.
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Antifibrinolytic agents make alpha1- and beta2-microglobulinuria poor markers of postcardiac surgery renal dysfunction.
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Antifungal pharmacotherapy for invasive mould infections.
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Antiplatelet drug resistance and drug-drug interactions: Role of cytochrome P450 3A4.
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Antiplatelet therapy: Clopidogrel-PPI interaction, an ongoing controversy.
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Appropriateness of medication prescribing in ambulatory elderly patients.
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Aspartate release from rat hippocampal synaptosomes.
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Aspirin use and outcomes in a community-based cohort of 7352 patients discharged after first hospitalization for heart failure.
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Association between Nephrotoxic Drug Combinations and Acute Kidney Injury in the Neonatal Intensive Care Unit.
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Association of adverse drug reactions with drug-drug and drug-disease interactions in frail older outpatients.
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Association of diabetes mellitus and glycemic control strategies with clinical outcomes after acute coronary syndromes.
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Azithromycin--spectrum of activity, pharmacokinetics, and clinical applications.
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Azole antifungals: 35 years of invasive fungal infection management.
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Baclofen interactions with nicotine in rats: effects on memory.
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Balancing the cyclooxygenase portfolio.
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Behavioral alterations in adolescent and adult rats caused by a brief subtoxic exposure to chlorpyrifos during neurulation.
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Behavioral and molecular effects of dopamine D1 receptor stimulation during naloxone-precipitated morphine withdrawal.
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Benzoate therapy and carnitine deficiency in non-ketotic hyperglycinemia.
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Bidirectional interaction of valproate and lamotrigine in healthy subjects.
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Biological assessments of a mixture of endocrine disruptors at environmentally relevant concentrations in water following UV/H2O2 oxidation.
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Bortezomib sensitizes pancreatic cancer cells to endoplasmic reticulum stress-mediated apoptosis.
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Branhamella catarrhalis activates human B lymphocytes following interactions with surface IgD and class I major histocompatibility complex antigens.
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Bupropion and guanfacine.
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Calcofluor white combination antifungal treatments for Trichophyton rubrum and Candida albicans.
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Cancer in People Living With HIV, Version 1.2018, NCCN Clinical Practice Guidelines in Oncology.
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Cardiovascular complications of breast cancer therapy in older adults.
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Caspofungin: first approved agent in a new class of antifungals.
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Cell-enhanced dissolution of carcinogenic lead chromate particles: the role of individual dissolution products in clastogenesis.
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Central neurotoxicity after exposure to organic lead: susceptibility to seizures.
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Changes in osmolality sensitize the response to capsaicin in trigeminal sensory neurons.
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Chlorpyrifos developmental neurotoxicity: interaction with glucocorticoids in PC12 cells.
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Chronic myelogenous leukemia.
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Chronic nicotine and dizocilpine effects on regionally specific nicotinic and NMDA glutamate receptor binding.
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Chronic nicotine interactions with clozapine and risperidone and attentional function in rats.
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Chronic nicotine working and reference memory effects in the 16-arm radial maze: interactions with D1 agonist and antagonist drugs.
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Circumventing tamoxifen resistance in breast cancers using antiestrogens that induce unique conformational changes in the estrogen receptor.
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Clinical consequences of bleeding among individuals with a recent acute coronary syndrome: Insights from the APPRAISE-2 trial.
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Clinical outcomes in patients with the concomitant use of clopidogrel and proton pump inhibitors after percutaneous coronary intervention: an analysis from the Guthrie Health Off-Label Stent (GHOST) investigators.
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Clopidogrel and PPI interaction: clinically relevant or not?
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Clopidogrel and proton pump inhibitors: influence of pharmacological interactions on clinical outcomes and mechanistic explanations.
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Clozapine treatment reverses dizocilpine-induced deficits of pre-pulse inhibition of tactile startle response.
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Co-medications that modulate liver injury and repair influence clinical outcome of acetaminophen-associated liver injury.
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Cocaine self-administration reduces excitatory responses in the mouse nucleus accumbens shell.
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Coenzyme Q10 and Heart Failure: A State-of-the-Art Review.
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Cognitive function and anticoagulation control in patients with atrial fibrillation.
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Combination antifungal therapy.
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Combined acetaldehyde and nicotine exposure depresses cardiac contraction in ventricular myocytes: prevention by folic acid.
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Combined activity of amphotericin B and 5-fluorocytosine against Cryptococcus neoformans in vitro and in vivo in mice.
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Combined effects of dietary phytoestrogen and synthetic endocrine-active compound on reproductive development in Sprague-Dawley rats: genistein and methoxychlor.
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Comedications alter drug-induced liver injury reporting frequency: Data mining in the WHO VigiBase™.
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Comment: Promethazine adverse events after implementation of a medication shortage interchange.
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Common mechanism of toxicity: a case study of organophosphorus pesticides.
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Comparison of in vitro and in vivo inhibition potencies of fluvoxamine toward CYP2C19.
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Comparison of two knowledge bases on the detection of drug-drug interactions.
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Complementary and alternative medicine in cardiovascular disease: a review of biologically based approaches.
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Complex drug interactions of HIV protease inhibitors 1: inactivation, induction, and inhibition of cytochrome P450 3A by ritonavir or nelfinavir.
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Complex drug interactions of the HIV protease inhibitors 3: effect of simultaneous or staggered dosing of digoxin and ritonavir, nelfinavir, rifampin, or bupropion.
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Conflicting results between randomized trials and observational studies on the impact of proton pump inhibitors on cardiovascular events when coadministered with dual antiplatelet therapy: systematic review.
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Contribution of itraconazole metabolites to inhibition of CYP3A4 in vivo.
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Copper ion-mediated modification of bases in DNA in vitro by benzoyl peroxide.
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Critical care perspective on immunotherapy in lung transplantation.
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Cyclosporin A inhibits chromium(VI)-induced apoptosis and mitochondrial cytochrome c release and restores clonogenic survival in CHO cells.
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Cyclosporine-inhibitable cerebral drug transport does not influence clinical methadone pharmacodynamics.
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Cystine-glutamate transport interactions in rat renal cortical tubules, brushborder vesicles, and cultured renal tubule cells.
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Cytochrome P4503A does not mediate the interaction between methadone and ritonavir-lopinavir.
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D1 and D2 antagonists reverse the effects of appetite suppressants on weight loss, food intake, locomotion, and rebalance spiking inhibition in the rat NAc shell.
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D1 and D2 dopamine receptor interactions with pilocarpine-induced oral activity in rats.
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Decreased blood-brain barrier permeability to fluorescein in streptozotocin-treated rats.
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Depot medroxyprogesterone acetate in combination with a twice-daily lopinavir-ritonavir-based regimen in HIV-infected women showed effective contraception and a lack of clinically significant interactions, with good safety and tolerability: results of the ACTG 5283 study.
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Design, implementation and evaluation of a clinical decision support system to prevent adverse drug events.
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Desipramine toxicity with terbinafine.
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Developmental exposure to an organophosphate flame retardant alters later behavioral responses to dopamine antagonism in zebrafish larvae.
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Dialogue with patient care organizations.
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Dialysate calcium concentration and the risk of sudden cardiac arrest in hemodialysis patients.
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Differential actions of diazepam and zolpidem in basolateral and central amygdala nuclei.
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Differential cardiac effects of growth hormone and insulin-like growth factor-1 in the rat. A combined in vivo and in vitro evaluation.
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Differential regulation of MeCP2 phosphorylation in the CNS by dopamine and serotonin.
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Differential reversal of lipophilic antifolate resistance in mammalian cells with modulators of the multidrug resistance phenotype.
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Differentiation of erythroleukemia cells in vitro: properties of chemical inducers.
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Does aspirin use adversely influence intermediate-term postdischarge outcomes for hospitalized patients who are treated with angiotensin-converting enzyme inhibitors or angiotensin receptor blockers? Findings from Organized Program to Facilitate Life-Saving Treatment in Hospitalized Patients with Heart Failure (OPTIMIZE-HF).
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Dosing recommendations and prescribing patterns for depressed medically ill hospitalized older patients.
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Dronedarone and vitamin K antagonists: a review of drug-drug interactions.
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Drug interaction between carbapenems and extended-release divalproex sodium in a patient with schizoaffective disorder.
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Drug interactions complicate antiplatelet therapy.
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Drug interactions: volatile anesthetics and opioids.
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Drug-drug interactions in older adults: which ones matter?
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Drug-drug-gene interaction risk among opioid users in the U.S. Department of Veterans Affairs.
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Drug-induced liver injury: Interactions between drug properties and host factors.
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Dystonia as a side effect of nonneuroleptics.
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Effect of Azithromycin on Venetoclax Pharmacokinetics in Healthy Volunteers: Implications for Dosing Venetoclax with P-gp Inhibitors.
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Effect of Intravenous Fentanyl on Ticagrelor Absorption and Platelet Inhibition Among Patients Undergoing Percutaneous Coronary Intervention: The PACIFY Randomized Clinical Trial (Platelet Aggregation With Ticagrelor Inhibition and Fentanyl).
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Effect of Pharmacogenomic Testing for Drug-Gene Interactions on Medication Selection and Remission of Symptoms in Major Depressive Disorder: The PRIME Care Randomized Clinical Trial.
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Effect of carbamazepine on Coumadin metabolism.
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Effect of colistin on phospholipid-based activated partial thromboplastin time clotting assay results in patients receiving concomitant heparin therapy.
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Effect of di(2-ethylhexyl) phthalate on DNA repair and lipid peroxidation in rat hepatocytes and on metabolic cooperation in Chinese hamster V-79 cells.
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Effect of low-dose aspirin on thromboxane production and the antihypertensive effect of captopril.
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Effect of metabotropic glutamate 5 receptor antagonists on morphine efficacy and tolerance in rats with neuropathic pain.
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Effect of rifampicin on S-ketamine and S-norketamine plasma concentrations in healthy volunteers after intravenous S-ketamine administration.
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Effect of ritonavir-induced cytochrome P450 3A4 inhibition on plasma fentanyl concentrations during patient-controlled epidural labor analgesia: a pharmacokinetic simulation.
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Effect of simultaneous didanosine administration on itraconazole absorption in healthy volunteers.
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Effects of ZD6169, a K ATP channel opener, on neurally-mediated plasma extravasation in the rat urinary bladder induced by chemical or electrical stimulation of nerves.
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Effects of beta-endorphin on ornithine decarboxylase in tissues of developing rats: a potential role for this endogenous neuropeptide in the modulation of tissue growth.
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Effects of daily dermal application of DEET and epermethrin, alone and in combination, on sensorimotor performance, blood-brain barrier, and blood-testis barrier in rats.
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Effects of dopamine D1 and D2 receptor antagonists on oral activity in rats.
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Effects of gamma hydroxybutyric acid on inhibition and excitation in rat neocortex.
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Effects of glutathione on chromium-induced DNA crosslinking and DNA polymerase arrest.
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Effects of reserpine on the content and properties of rat adrenal medullary storage vesicles.
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Effects of sazetidine-A, a selective α4β2* nicotinic receptor desensitizing agent, on body temperature regulation in mice and rats.
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Effects of single and combined exposures to benzo(a)pyrene and 3,3'4,4'5-pentachlorobiphenyl on EROD activity and development in Fundulus heteroclitus.
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Effects of sofosbuvir-based hepatitis C treatment on the pharmacokinetics of tenofovir in HIV/HCV-coinfected individuals receiving tenofovir disoproxil fumarate.
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Effects of the polycyclic aromatic hydrocarbon heterocycles, carbazole and dibenzothiophene, on in vivo and in vitro CYP1A activity and polycyclic aromatic hydrocarbon-derived embryonic deformities.
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Effects of tobacco smoking and nicotine on cancer treatment.
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Efficacy and safety of St. John's wort for the treatment of major depression.
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Efficacy and safety of angiotensin receptor blockade are not modified by aspirin in patients with chronic heart failure: a cohort study from the Candesartan in Heart failure--Assessment of Reduction in Mortality and morbidity (CHARM) programme.
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Elevated mu-opioid receptor expression in the nucleus of the solitary tract accompanies attenuated withdrawal signs after chronic low dose naltrexone in opiate-dependent rats.
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Emodin induces apoptosis in human promyeloleukemic HL-60 cells accompanied by activation of caspase 3 cascade but independent of reactive oxygen species production.
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Enfuvirtide: the first therapy to inhibit the entry of HIV-1 into host CD4 lymphocytes.
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Enhancement of irinotecan (CPT-11) activity against central nervous system tumor xenografts by alkylating agents.
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Epidemiology of drug-disease interactions in older veteran nursing home residents.
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Establishment of a melphalan-resistant rhabdomyosarcoma xenograft with cross-resistance to vincristine and enhanced sensitivity following buthionine sulfoximine-mediated glutathione depletion.
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Estradiol replacement enhances cocaine-stimulated locomotion in female C57BL/6 mice through estrogen receptor alpha.
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Ethanol and magnesium ions inhibit N-methyl-D-aspartate-mediated synaptic potentials in an interactive manner.
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Evaluation of the dofetilide risk-management program.
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Evaluation of the pharmacokinetic drug interaction potential of tivantinib (ARQ 197) using cocktail probes in patients with advanced solid tumours.
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Exercise biology and medicine: innovative research to improve global health.
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Extended Oral Antibiotics and Infection Prophylaxis after a Primary or Revision Total Knee Arthroplasty.
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Facilitation of granule cell epileptiform activity by mossy fiber-released zinc in the pilocarpine model of temporal lobe epilepsy.
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Fast endocytosis is inhibited by GABA-mediated chloride influx at a presynaptic terminal.
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Flunarizine enhancement of melphalan activity against drug-sensitive/resistant rhabdomyosarcoma.
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Fluvoxamine-theophylline interaction: gap between in vitro and in vivo inhibition constants toward cytochrome P4501A2.
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Frequency of high-risk use of QT-prolonging medications.
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GSNO reductase and beta2-adrenergic receptor gene-gene interaction: bronchodilator responsiveness to albuterol.
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Guidance on the emergent reversal of oral thrombin and factor Xa inhibitors.
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Guidelines for the diagnosis and treatment of non-ST-segment elevation acute coronary syndromes.
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Heparinase I (neutralase) reversal of systemic anticoagulation.
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Histamine H1 receptor involvement in prepulse inhibition and memory function: relevance for the antipsychotic actions of clozapine.
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How important are drug-drug interactions to the health of older adults?
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How to manage drug interactions.
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Ibrutinib: a new targeted therapy for hematologic cancers.
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Imbalances emerge in cardiac autonomic cell signaling after neonatal exposure to terbutaline or chlorpyrifos, alone or in combination.
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Immediate and delayed neurotoxicity after mechlorethamine preparation for bone marrow transplantation.
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Immunostimulatory properties of genomic DNA from different bacterial species.
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Impact of Polypharmacy and P-Glycoprotein- and CYP3A4-Modulating Drugs on Safety and Efficacy of Oral Anticoagulation Therapy in Patients with Atrial Fibrillation.
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Impact of inappropriate drug use on health services utilization among representative older community-dwelling residents.
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Impact of morphine on antiplatelet effects of oral P2Y12 receptor inhibitors.
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Impact of prophylactic oseltamivir on INR in patients on stable warfarin therapy.
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Importance of potent P2Y(12) receptor blockade in acute myocardial infarction: focus on prasugrel.
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Improving neutralization potency and breadth by combining broadly reactive HIV-1 antibodies targeting major neutralization epitopes.
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In vitro interactions between antifungals and immunosuppressants against Aspergillus fumigatus.
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Incidence and predictors of all and preventable adverse drug reactions in frail elderly persons after hospital stay.
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Incidence of Drug Interactions Identified by Clinical Pharmacists in Veterans Initiating Treatment for Chronic Hepatitis C Infection.
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Incidence of caffeine in serum of patients undergoing dipyridamole myocardial perfusion stress test by an intensive versus routine caffeine history screening.
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Increased melphalan activity in intracranial human medulloblastoma and glioma xenografts following buthionine sulfoximine-mediated glutathione depletion.
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Individual Proton Pump Inhibitors and Outcomes in Patients With Coronary Artery Disease on Dual Antiplatelet Therapy: A Systematic Review.
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Induction of urinary excretion of 3-nitrotyrosine, a marker of oxidative stress, following administration of pyridostigmine bromide, DEET (N,N-diethyl-m-toluamide) and permethrin, alone and in combination in rats.
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Infection and cyclosporine.
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Influence of HIV antiretrovirals on methadone N-demethylation and transport.
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Influence of Successful Chronic Hepatitis C Virus Treatment with Ledipasvir/Sofosbuvir on Warfarin Dosing Requirements in Four Veterans.
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Influence of hepatic and intestinal cytochrome P4503A activity on the acute disposition and effects of oral transmucosal fentanyl citrate.
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Interacting medication use and the treatment effects of apixaban versus warfarin: results from the ARISTOTLE Trial.
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Interaction between digoxin and dronedarone in the PALLAS trial.
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Interaction between marihuana and ethanol: effects on psychomotor performance.
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Interaction of endosulfan and dietary vitamin A on rat hepatic drug metabolising enzymes.
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Interaction of vitamin A and cortisol on liver and plasma lipids of rats.
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Interactions between heparins, glycoprotein IIb/IIIa antagonists, and coronary intervention. The Global Registry of Acute Coronary Events (GRACE).
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Interactions between highly active antiretroviral therapy and over-the-counter agents: a cautionary note.
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Interactions of vasoactive intestinal polypeptide and cholecystokinin octapeptide on the control of gallbladder contraction.
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Is bleeding a necessary evil? The inherent risk of antithrombotic pharmacotherapy used for stroke prevention in atrial fibrillation.
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Isoflurane alters the kinetics of oral cyclosporine.
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Isoproterenol inhibits the increase in microvascular membrane permeability produced by bradykinin.
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Ketanserin attenuates nicotine-induced working memory improvement in rats.
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Lack of indinavir effects on methadone disposition despite inhibition of hepatic and intestinal cytochrome P4503A (CYP3A).
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Lactogenic and somatogenic hormones regulate the expression of neuropeptide Y and cocaine- and amphetamine-regulated transcript in rat insulinoma (INS-1) cells: interactions with glucose and glucocorticoids.
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Leptin mediates the parathyroid hormone-related protein paracrine stimulation of fetal lung maturation.
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Leptin opposes insulin's effects on fatty acid partitioning in muscles isolated from obese ob/ob mice.
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Leveraging Physiologically Based Pharmacokinetic Modeling and Experimental Data to Guide Dosing Modification of CYP3A-Mediated Drug-Drug Interactions in the Pediatric Population.
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Locomotor and sensorimotor performance deficit in rats following exposure to pyridostigmine bromide, DEET, and permethrin, alone and in combination.
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Lovastatin and coadministered antihypertensive/cardiovascular agents.
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Machine Learning Uncovers Food- and Excipient-Drug Interactions.
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Magnesium sulfate inhibits the oxytocin-induced production of inositol 1,4,5-trisphosphate in cultured human myometrial cells.
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Magnitude and ethanol sensitivity of tonic GABAA receptor-mediated inhibition in dentate gyrus changes from adolescence to adulthood.
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Management of drug and food interactions with azole antifungal agents in transplant recipients.
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Management of patients coinfected with HCV and HIV: a close look at the role for direct-acting antivirals.
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Management of platelet-directed pharmacotherapy in patients with atherosclerotic coronary artery disease undergoing elective endoscopic gastrointestinal procedures.
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Marijuana Use in the Anesthetized Patient: History, Pharmacology, and Anesthetic Considerations.
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Maternal cadmium, iron and zinc levels, DNA methylation and birth weight.
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Mathematical modeling of cell metabolism
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Mechanism of efavirenz influence on methadone pharmacokinetics and pharmacodynamics.
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Mechanism of ritonavir changes in methadone pharmacokinetics and pharmacodynamics: I. Evidence against CYP3A mediation of methadone clearance.
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Mechanism of ritonavir changes in methadone pharmacokinetics and pharmacodynamics: II. Ritonavir effects on CYP3A and P-glycoprotein activities.
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Medical management of adrenal cortical disease.
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Metabolism of dapsone to its hydroxylamine by CYP2E1 in vitro and in vivo.
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Metformin Use May Moderate the Effect of DPP-4 Inhibitors on Cardiovascular Outcomes.
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Methadone Disposition: Implementing Lessons Learned.
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Methadone pharmacokinetics are independent of cytochrome P4503A (CYP3A) activity and gastrointestinal drug transport: insights from methadone interactions with ritonavir/indinavir.
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Milnacipran: beyond a role of antidepressant.
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Mitogenesis, cell migration, and loss of focal adhesions induced by tenascin-C interacting with its cell surface receptor, annexin II.
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Mitomycin C and menadione for the treatment of lung cancer: a phase II trial.
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Modeling the developmental neurotoxicity of nicotine in vitro: cell acquisition, growth and viability in PC12 cells.
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Modulating role of lithium on dopamine turnover, prolactin release, and behavioral supersensitivity following haloperidol and reserpine.
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Modulation of ATP-induced calcium signaling by progesterone in T47D-Y breast cancer cells.
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Multifactorial optimization of endothelial cell growth using modular synthetic extracellular matrices.
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Muscarinic inhibition of substance P induced ion secretion in piglet jejunum.
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N-acetylcysteine does not modify nitroglycerin-induced tolerance in canine vascular rings.
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NMDA receptor antagonists ameliorate the stepping deficits produced by unilateral medial forebrain bundle injections of 6-OHDA in rats.
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National Academy of Clinical Biochemistry Laboratory Medicine practice guidelines: Clinical utilization of cardiac biomarker testing in heart failure.
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Neuregulin-1 enhances depolarization-induced GABA release.
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Neurosteroid modulation of GABAergic neurotransmission in the central amygdala: a role for NMDA receptors.
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Neurotensin reduces glutamatergic transmission in the dorsolateral striatum via retrograde endocannabinoid signaling.
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Nicotine inhibits voltage-dependent sodium channels and sensitizes vanilloid receptors.
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Nicotine interactions with haloperidol, clozapine and risperidone and working memory function in rats.
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Nicotine interactions with low-dose alcohol: pharmacological influences on smoking and drinking motivation.
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Nicotine-alcohol interactions and attentional performance on an operant visual signal detection task in female rats.
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Nicotine-antipsychotic drug interactions and attentional performance in female rats.
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Nicotine-dizocilpine interactions and working and reference memory performance of rats in the radial-arm maze.
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Nicotinic and muscarinic interactions and choice accuracy in the radial-arm maze.
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Nicotinic antagonist effects in the mediodorsal thalamic nucleus: regional heterogeneity of nicotinic receptor involvement in cognitive function.
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Nicotinic interactions with antipsychotic drugs, models of schizophrenia and impacts on cognitive function.
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Nicotinic-antipsychotic drug interactions and cognitive function.
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Nicotinic-glutamatergic interactions and attentional performance on an operant visual signal detection task in female rats.
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Nicotinic-serotonergic drug interactions and attentional performance in rats.
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Ofloxacin: its pharmacology, pharmacokinetics, and potential for clinical application.
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Olanzapine interactions with nicotine and mecamylamine in rats: effects on memory function.
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Opposite effects of lead on chemical carcinogenesis in kidney and liver of rats.
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Oral activated charcoal prevents experimental cerebral malaria in mice and in a randomized controlled clinical trial in man did not interfere with the pharmacokinetics of parenteral artesunate.
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Oral anticoagulants for stroke prevention in atrial fibrillation: current status, special situations, and unmet needs.
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Oral anticoagulants in older adults with atrial fibrillation.
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Oral poly(ADP-ribose) polymerase-1 inhibitor BSI-401 has antitumor activity and synergizes with oxaliplatin against pancreatic cancer, preventing acute neurotoxicity.
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Oxidative mechanisms contributing to the developmental neurotoxicity of nicotine and chlorpyrifos.
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PA tablets: investigational compounds combining aspirin and omeprazole for cardioprotection.
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PI3 kinase is involved in cocaine behavioral sensitization and its reversal with brain area specificity.
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Paradoxical intraocular pressure elevation after combined therapy with latanoprost and bimatoprost.
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Paroxetine: safety and tolerability issues.
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Perfluorooctyl bromide (perflubron) attenuates oxidative injury to biological and nonbiological systems.
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Pergolide interactions with nicotine and pilocarpine in rats on the radial-arm maze.
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Periischemic cerebral blood flow (CBF) does not explain beneficial effects of isoflurane on outcome from near-complete forebrain ischemia in rats.
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Pharmacodynamic evaluation of clopidogrel plus PA32540: the Spaced PA32540 With Clopidogrel Interaction Gauging (SPACING) study.
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Pharmacogenomics for personalized pain medicine.
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Pharmacokinetic interactions and safety evaluations of coadministered tafenoquine and chloroquine in healthy subjects.
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Pharmacokinetic interactions between buprenorphine and antiretroviral medications.
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Pharmacokinetics and pharmacodynamics of ticagrelor in patients with stable coronary artery disease: results from the ONSET-OFFSET and RESPOND studies.
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Pharmacokinetics of levetiracetam.
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Phase I study of SU5416, a small molecule inhibitor of the vascular endothelial growth factor receptor (VEGFR) in refractory pediatric central nervous system tumors.
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Phase I trial of interleukin-2 plus doxorubicin.
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Phase I/II study of the P-glycoprotein modulator PSC 833 in patients with acute myeloid leukemia.
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Phenamil: an irreversible inhibitor of sodium channels in the toad urinary bladder.
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Physiologically-Based Pharmacokinetic Modeling Characterizes the CYP3A-Mediated Drug-Drug Interaction Between Fluconazole and Sildenafil in Infants.
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Polyamines antagonize N-methyl-D-aspartate-evoked depolarizations, but reduce Mg2+ block.
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Polypharmacy management in Medicare managed care: changes in prescribing by primary care physicians resulting from a program promoting medication reviews.
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Posaconazole's impact on prophylaxis and treatment of invasive fungal infections: an update.
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Postsynaptic mechanisms govern the differential excitation of cortical neurons by thalamic inputs.
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Postsynaptic requirement for Abl kinases in assembly of the neuromuscular junction.
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Potency of combined estrogenic pesticides.
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Potential interactions between GABAb and cholinergic systems: baclofen augments scopolamine-induced performance deficits in the eight-arm radial maze.
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Potential kidney toxicity from the antiviral drug tenofovir: new indications, new formulations, and a new prodrug.
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Practical aspects of MAO inhibitor therapy.
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Preclinical evaluation of gemcitabine combination regimens for application in acute myeloid leukemia.
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Prediction in drug abuse: cocaine interactions with alcohol and buprenorphine.
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Prenatal nicotine changes the response to postnatal chlorpyrifos: Interactions targeting serotonergic synaptic function and cognition.
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Psychopharmacological interactions between nicotine and ethanol.
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Psychophysiological interactions between caffeine and nicotine.
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Psychotherapeutic agents in older adults. Metabolism, bioavailability, and drug interactions.
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Pyrimethamine pharmacokinetics in human immunodeficiency virus-positive patients seropositive for Toxoplasma gondii.
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Quality of pharmacotherapy and outcomes for older veterans discharged from the emergency department.
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Quenching of DNA cross-link precursors of chloroethylnitrosoureas and attenuation of DNA interstrand cross-linking by glutathione.
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Quinidine as a probe for the role of p-glycoprotein in the intestinal absorption and clinical effects of fentanyl.
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Radial-arm maze performance in rats is impaired by a combination of nicotinic-cholinergic and D2 dopaminergic antagonist drugs.
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Randomized comparison of direct thrombin inhibition versus heparin in conjunction with fibrinolytic therapy for acute myocardial infarction: results from the GUSTO-IIb Trial. Global Use of Strategies to Open Occluded Coronary Arteries in Acute Coronary Syndromes (GUSTO-IIb) Investigators.
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Rational theophylline use in older asthmatics.
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Real-world implications of QT prolongation in patients receiving voriconazole and amiodarone.
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Reboxetine: a selective norepinephrine reuptake inhibitor for the treatment of depression.
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Reducing polypharmacy: evidence from a simple quality improvement initiative.
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Regulation of beta adrenergic receptors in isolated frog erythrocyte plasma membranes.
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Relationship between dietary retinol and lipofuscin in the retinal pigment epithelium.
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Reliability of a modified medication appropriateness index in ambulatory older persons.
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Research Priorities to Advance the Health and Health Care of Older Adults with Multiple Chronic Conditions.
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Restorative effects of GDNF on striatal dopamine release in rats treated with neurotoxic doses of methamphetamine.
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Reversal of a mecamylamine-induced cognitive deficit with the D2 agonist, LY 171555.
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Reversal of physiological stress-induced resistance to topoisomerase II inhibitors using an inducible phosphorylation site-deficient mutant of I kappa B alpha.
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Risk of major bleeding with concomitant dual antiplatelet therapy after percutaneous coronary intervention in patients receiving long-term warfarin therapy.
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Role of C-terminal serines in desensitization and phosphorylation of the mouse thromboxane receptor.
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Role of P-glycoprotein in the intestinal absorption and clinical effects of morphine.
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Role of the GLT-1 subtype of glutamate transporter in glutamate homeostasis: the GLT-1-preferring inhibitor WAY-855 produces marginal neurotoxicity in the rat hippocampus.
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Roundtable panel discussion: the role of glycoprotein IIb-IIIa receptor inhibitors in acute ischemic coronary syndromes.
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Safety considerations in the use of drug combinations during general anaesthesia.
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Safety events in kidney transplant recipients: results from the folic Acid for vascular outcome reduction in transplant trial.
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Safety of aprotinin in heparinized and nonheparinized patients.
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Sazetidine-A, a selective α4β2 nicotinic acetylcholine receptor ligand: effects on dizocilpine and scopolamine-induced attentional impairments in female Sprague-Dawley rats.
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Schizophrenia, drug therapy, and monitoring.
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Selective activation of cannabinoid CB(2) receptors suppresses spinal fos protein expression and pain behavior in a rat model of inflammation.
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Sensorimotor deficit and cholinergic changes following coexposure with pyridostigmine bromide and sarin in rats.
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Sensorimotor deficits and increased brain nicotinic acetylcholine receptors following exposure to chlorpyrifos and/or nicotine in rats.
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Serotonin syndrome in a chronic-pain patient receiving concurrent methadone, ciprofloxacin, and venlafaxine.
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Serotonin-lesion myoclonic syndromes. I. Neurochemical profile and S-1 receptor binding.
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Sex-related differences in clinical drug response: Implications for women's health
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Sex-related spatial learning differences after prenatal cocaine exposure in the young adult rat.
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Silver ions increase auxin efflux independently of effects on ethylene response.
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Simultaneous assessment of drug interactions with low- and high-extraction opioids: application to parecoxib effects on the pharmacokinetics and pharmacodynamics of fentanyl and alfentanil.
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Simultaneous determination of alfentanil and midazolam in human plasma using liquid chromatography and tandem mass spectrometry.
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Single-dose disulfiram inhibition of chlorzoxazone metabolism: a clinical probe for P450 2E1.
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Single-point sampling for assessment of constitutive, induced, and inhibited cytochrome P450 3A activity with alfentanil or midazolam.
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Specific functions of synaptically localized potassium channels in synaptic transmission at the neocortical GABAergic fast-spiking cell synapse.
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Statin Safety and Associated Adverse Events: A Scientific Statement From the American Heart Association.
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Statin therapy--Part II: Clinical considerations for cardiovascular disease.
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Statins do not affect platelet inhibition with clopidogrel during coronary stenting.
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Stereoselective bupropion hydroxylation as an in vivo phenotypic probe for cytochrome P4502B6 (CYP2B6) activity.
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Subacute ethanol consumption reverses p-xylene-induced decreases in axonal transport.
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Suboptimal prescribing in older inpatients and outpatients.
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Survey of methadone-drug interactions among patients of methadone maintenance treatment program in Taiwan.
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Susceptibility of Aspergillus to 5-fluorocytosine and amphotericin B alone and in combination.
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Swainsonine protects both murine and human haematopoietic systems from chemotherapeutic toxicity.
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Symposium overview: mechanism of action of nicotine on neuronal acetylcholine receptors, from molecule to behavior.
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Symptom exacerbation in psychotically depressed adolescents due to high desipramine plasma concentrations.
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Synergistic embryotoxicity of polycyclic aromatic hydrocarbon aryl hydrocarbon receptor agonists with cytochrome P4501A inhibitors in Fundulus heteroclitus.
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Tamoxifen pharmacogenomics: the role of CYP2D6 as a predictor of drug response.
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The Ca(2+) channel antagonists mibefradil and pimozide inhibit cell growth via different cytotoxic mechanisms.
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The anticoagulated patient: strategies for effective blood loss management.
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The clinical management of HCV in the HIV-infected patient.
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The clinical pharmacogenetics implementation consortium guideline for SLCO1B1 and simvastatin-induced myopathy: 2014 update.
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The clopidogrel-statin interaction.
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The convergence of herb pharmacodynamics and herb-drug interactions on hemostasis.
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The drug-drug interaction between proton pump inhibitors and clopidogrel.
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The effect of active site-inhibited factor VIIa on tissue factor-initiated coagulation using platelets before and after aspirin administration.
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The effect of antibiotic additions on the mechanical properties of acrylic cement.
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The effect of aprepitant and race on the pharmacokinetics of cyclophosphamide in breast cancer patients.
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The effect of endothelin-1 on muscle microcirculation and its attenuation by verapamil.
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The effect of quinidine, propranolol and their combination on experimental atrial and ventricular arrhythmias.
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The effect of the interaction of propofol and alfentanil on recall, loss of consciousness, and the Bispectral Index.
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The effects of MDCO-2010, a serine protease inhibitor, on activated clotting time in blood obtained from volunteers and cardiac surgical patients.
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The influence of drug properties and host factors on delayed onset of symptoms in drug-induced liver injury.
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The interplay of prolactin and the glucocorticoids in the regulation of beta-cell gene expression, fatty acid oxidation, and glucose-stimulated insulin secretion: implications for carbohydrate metabolism in pregnancy.
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The microtubule interacting drug candidate NAP protects against kainic acid toxicity in a rat model of epilepsy.
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The newer antiepileptic drugs: carbamazepine and valproic acid.
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The non-covalent interaction of pyrrolo[2, 1-c] [1, 4]benzodiazepine-5, 11-diones with DNA.
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The novel combination of theophylline and bambuterol as a potential treatment of hypoxemia in humans.
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The pharmacokinetics of timegadine and two of its metabolites after multiple oral dosing, and the effects of concomitant administration of ibuprofen.
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The quality of pharmacotherapy in older veterans discharged from the emergency department or urgent care clinic.
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The relation of quinidine-induced elevation of serum digoxin concentration to the conversion of atrial fibrillation-flutter: a pilot study.
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The response to inhaled nitric oxide in patients with pulmonary artery hypertension is not masked by baseline vasodilator use.
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The role of alpha7 and alpha4beta2 nicotinic receptors in the nicotine-induced anxiolytic effect in zebrafish.
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The role of cytochrome P450 3A4 in alfentanil clearance. Implications for interindividual variability in disposition and perioperative drug interactions.
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The sea urchin embryo, an invertebrate model for mammalian developmental neurotoxicity, reveals multiple neurotransmitter mechanisms for effects of chlorpyrifos: therapeutic interventions and a comparison with the monoamine depleter, reserpine.
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The vulnerable endothelium: priming the vascular endothelium for thrombosis with unfractionated heparin: biologic plausibility for observations from the Superior Yield of the New Strategy of Enoxaparin, Revascularization and GlYcoprotein IIb/IIIa Inhibitors (SYNERGY) trial.
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The α₂-adrenergic antagonist idazoxan counteracts prepulse inhibition deficits caused by amphetamine or dizocilpine in rats.
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Thrombin enhances monocyte secretion of tumor necrosis factor and interleukin-1 beta by two distinct mechanisms.
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Thrombomodulin increases the rate of thrombin inhibition by BPTI.
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Tolvaptan administration does not affect steady state amiodarone concentrations in patients with cardiac arrhythmias.
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Transient increase in plasma quinidine concentrations during ketoconazole-quinidine therapy.
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Transiently overexpressed alpha2-adrenoceptors and their control of DNA synthesis in the developing brain.
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Treatment considerations for patients with neuropathic pain and other medical comorbidities.
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Treatment options for invasive fungal infections.
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Tricyclic-induced akathisia in patients taking conjugated estrogens.
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Understanding therapeutic equivalence in epilepsy.
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Usability of mobile technology to screen for drug-drug interactions in kidney transplant patients.
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Use of control steady-state serum digoxin levels for predicting serum digoxin concentration after quinidine administration.
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Use of sildenafil (Viagra) in patients with cardiovascular disease. Technology and Practice Executive Committee.
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Vasodilator administration in the presence of beta-adrenergic blockade.
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Ventral hippocampal NMDA blockade and nicotinic effects on memory function.
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Ventral hippocampal ibotenic acid lesions block chronic nicotine-induced spatial working memory improvement in rats.
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Virologic failure in therapy-naive subjects on aplaviroc plus lopinavir-ritonavir: detection of aplaviroc resistance requires clonal analysis of envelope.
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Warfarin and acetaminophen interaction: a summary of the evidence and biologic plausibility.
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Warfarin reversal with prothrombin complex concentrate confers better antifibrinolytic activity compared with recombinant activated factor VII.
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What clinicians should know about the QT interval.
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What is the role of combination drug therapy in the treatment of overactive bladder? ICI-RS 2014.
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rHuEPO and improved treatment outcomes: potential modes of action.
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tPA-mediated generation of plasmin is catalyzed by the proteoglycan NG2.
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Keywords of People
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Curtis, Lesley H.,
Professor in Population Health Sciences,
Medicine, General Internal Medicine
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Erickson, Harold Paul,
Professor Emeritus of Cell Biology,
Cell Biology
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Freemark, Michael Scott,
Robert C. Atkins, M.D. and Veronica Atkins Distinguished Professor of Pediatrics, in the School of Medicine,
Pediatrics, Endocrinology
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McDonnell, Donald Patrick,
Glaxo-Wellcome Distinguished Professor of Molecular Cancer Biology, in the School of Medicine,
Cell Biology
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Middleton, John Paul,
Professor of Medicine,
Medicine, Nephrology
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O'Connor, Christopher Michael,
Richard Sean Stack, M.D. Distinguished Professor,
Medicine, Clinical Pharmacology
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Wu, Li-Tzy,
Professor in Psychiatry and Behavioral Sciences,
Medicine, General Internal Medicine