Drug Interactions

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  Subject Areas on Research

  • 2-Methoxyestradiol, an endogenous estrogen metabolite, induces apoptosis in endothelial cells and inhibits angiogenesis: possible role for stress-activated protein kinase signaling pathway and Fas expression. 
  • 5-HT2C Agonists Modulate Schizophrenia-Like Behaviors in Mice. 
  • 9-cis retinoic acid regulation of rat growth hormone gene expression: potential roles of multiple nuclear hormone receptors. 
  • A direct, general approach based on isobolograms for assessing the joint action of drugs in pre-clinical experiments. 
  • A method for assessing drug therapy appropriateness. 
  • A narrative review of the cardiovascular risks associated with concomitant aspirin and NSAID use. 
  • A nineteen-year-old man with altered mental status. 
  • A peripheral cannabinoid mechanism suppresses spinal fos protein expression and pain behavior in a rat model of inflammation. 
  • A pharmacological study of celecoxib and gemcitabine in patients with advanced pancreatic cancer. 
  • A randomized comparative study to determine the effect of omeprazole on the peak serum concentration of itraconazole oral solution. 
  • A randomized, controlled trial of a clinical pharmacist intervention to improve inappropriate prescribing in elderly outpatients with polypharmacy. 
  • A study of the potential confounding effects of diet, caffeine, nicotine and lorazepam on the stability of plasma and urinary homovanillic acid levels in patients with schizophrenia. 
  • ACC/AHA expert consensus document. Use of sildenafil (Viagra) in patients with cardiovascular disease. American College of Cardiology/American Heart Association. 
  • ACE inhibitors do not affect erythropoietin efficacy in haemodialysis patients. 
  • Absence of interaction between atorvastatin or other statins and clopidogrel: results from the interaction study. 
  • Acute ethanol administration downregulates human immunodeficiency virus-1 glycoprotein 120-induced KC and RANTES production by murine Kupffer cells and splenocytes. 
  • Acute nicotine interactions with nicotinic and muscarinic antagonists: working and reference memory effects in the 16-arm radial maze. 
  • Adolescent and adult rats respond differently to nicotine and alcohol: motor activity and body temperature. 
  • Adverse drug events in high risk older outpatients. 
  • Age, dose, and environmental temperature are risk factors for topiramate-related hyperthermia. 
  • Age-related differences in neurosteroid potentiation of muscimol-stimulated 36Cl(-) flux following chronic ethanol treatment. 
  • Aging and cancer. 
  • Alendronate-induced ulcerative esophagitis. 
  • Alpha-tocopheryl succinate protects hepatocytes from chemical-induced toxicity under physiological calcium conditions. 
  • Alphavirus replicon particles acting as adjuvants promote CD8+ T cell responses to co-delivered antigen. 
  • Alteration of digoxin pharmacokinetics by a single dose of quinidine. 
  • Altered responsiveness to alcohol after exposure to organic lead. 
  • Amphotericin B: 30 years of clinical experience. 
  • Amyloid precursor protein 96-110 and beta-amyloid 1-42 elicit developmental anomalies in sea urchin embryos and larvae that are alleviated by neurotransmitter analogs for acetylcholine, serotonin and cannabinoids. 
  • An approach to the assessment of therapeutic drug interactions with fixed combination drug products. 
  • An exploratory study of the combined effects of orally administered methylphenidate and delta-9-tetrahydrocannabinol (THC) on cardiovascular function, subjective effects, and performance in healthy adults. 
  • An in vitro study of horizontal connections in the intermediate layer of the superior colliculus. 
  • An overview of the clinical rationale for advancing gender-related psychopharmacology and drug abuse research. 
  • Analysis of the risks associated with calcium channel blockade: implications for the obstetrician-gynecologist. 
  • Anidulafungin: a new echinocandin for the treatment of fungal infections. 
  • Antagonist treatment of opioid withdrawal translational low dose approach. 
  • Antagonistic Growth Effects of Mercury and Selenium in Caenorhabditis elegans Are Chemical-Species-Dependent and Do Not Depend on Internal Hg/Se Ratios. 
  • Anti proliferative activity of ELACY (CP-4055) in combination with cloretazine (VNP40101M), idarubicin, gemcitabine, irinotecan and topotecan in human leukemia and lymphoma cells. 
  • Anticoagulation: managing adverse events in patients receiving anticoagulation and perioperative care. 
  • Anticoagulation: monitoring of patients receiving anticoagulation. 
  • Antidepressant therapy in patients with ischemic heart disease. 
  • Antidote-mediated control of an anticoagulant aptamer in vivo. 
  • Antifibrinolytic agents make alpha1- and beta2-microglobulinuria poor markers of postcardiac surgery renal dysfunction. 
  • Antifungal pharmacotherapy for invasive mould infections. 
  • Antiplatelet drug resistance and drug-drug interactions: Role of cytochrome P450 3A4. 
  • Antiplatelet therapy: Clopidogrel-PPI interaction, an ongoing controversy. 
  • Antiproliferative action of dopamine and norepinephrine in neuroblastoma cells expressing the human dopamine transporter. 
  • Appropriateness of medication prescribing in ambulatory elderly patients. 
  • Aripiprazole as adjunctive therapy for patients with major depressive disorder: overview and implications of clinical trial data. 
  • Aspartate release from rat hippocampal synaptosomes. 
  • Aspirin use and outcomes in a community-based cohort of 7352 patients discharged after first hospitalization for heart failure. 
  • Association of adverse drug reactions with drug-drug and drug-disease interactions in frail older outpatients. 
  • Association of diabetes mellitus and glycemic control strategies with clinical outcomes after acute coronary syndromes. 
  • Azithromycin--spectrum of activity, pharmacokinetics, and clinical applications. 
  • Azole antifungals: 35 years of invasive fungal infection management. 
  • Baclofen interactions with nicotine in rats: effects on memory. 
  • Balancing the cyclooxygenase portfolio. 
  • Behavioral alterations in adolescent and adult rats caused by a brief subtoxic exposure to chlorpyrifos during neurulation. 
  • Benzoate therapy and carnitine deficiency in non-ketotic hyperglycinemia. 
  • Bidirectional interaction of valproate and lamotrigine in healthy subjects. 
  • Biological assessments of a mixture of endocrine disruptors at environmentally relevant concentrations in water following UV/H2O2 oxidation. 
  • Bortezomib sensitizes pancreatic cancer cells to endoplasmic reticulum stress-mediated apoptosis. 
  • Branhamella catarrhalis activates human B lymphocytes following interactions with surface IgD and class I major histocompatibility complex antigens. 
  • Brief Report: Hormonal Contraception Is Not Associated With Reduced ART Effectiveness Among Women Initiating ART: Evidence From Longitudinal Data. 
  • Busulfan and metronidazole: an often forgotten but significant drug interaction. 
  • Calcofluor white combination antifungal treatments for Trichophyton rubrum and Candida albicans. 
  • Cardiovascular complications of breast cancer therapy in older adults. 
  • Caspofungin: first approved agent in a new class of antifungals. 
  • Celecoxib does not affect the antiplatelet activity of aspirin in healthy volunteers. 
  • Cell-enhanced dissolution of carcinogenic lead chromate particles: the role of individual dissolution products in clastogenesis. 
  • Central neurotoxicity after exposure to organic lead: susceptibility to seizures. 
  • Changes in anticholinergic load from regular prescribed medications in palliative care as death approaches. 
  • Changes in osmolality sensitize the response to capsaicin in trigeminal sensory neurons. 
  • Chlorpyrifos developmental neurotoxicity: interaction with glucocorticoids in PC12 cells. 
  • Chronic myelogenous leukemia. 
  • Chronic nicotine and dizocilpine effects on regionally specific nicotinic and NMDA glutamate receptor binding. 
  • Chronic nicotine interactions with clozapine and risperidone and attentional function in rats. 
  • Chronic nicotine working and reference memory effects in the 16-arm radial maze: interactions with D1 agonist and antagonist drugs. 
  • Circumventing tamoxifen resistance in breast cancers using antiestrogens that induce unique conformational changes in the estrogen receptor. 
  • Clinical outcomes in patients with the concomitant use of clopidogrel and proton pump inhibitors after percutaneous coronary intervention: an analysis from the Guthrie Health Off-Label Stent (GHOST) investigators. 
  • Clopidogrel and PPI interaction: clinically relevant or not? 
  • Clopidogrel and proton pump inhibitors: influence of pharmacological interactions on clinical outcomes and mechanistic explanations. 
  • Clozapine treatment reverses dizocilpine-induced deficits of pre-pulse inhibition of tactile startle response. 
  • Co-medications that modulate liver injury and repair influence clinical outcome of acetaminophen-associated liver injury. 
  • Cocaine self-administration reduces excitatory responses in the mouse nucleus accumbens shell. 
  • Coenzyme Q10 and Heart Failure: A State-of-the-Art Review. 
  • Cognitive function and anticoagulation control in patients with atrial fibrillation. 
  • Colistin: still a lifesaver for the 21st century? 
  • Combination antifungal therapy. 
  • Combined acetaldehyde and nicotine exposure depresses cardiac contraction in ventricular myocytes: prevention by folic acid. 
  • Combined activity of amphotericin B and 5-fluorocytosine against Cryptococcus neoformans in vitro and in vivo in mice. 
  • Combined effects of dietary phytoestrogen and synthetic endocrine-active compound on reproductive development in Sprague-Dawley rats: genistein and methoxychlor. 
  • Comedications alter drug-induced liver injury reporting frequency: Data mining in the WHO VigiBase™. 
  • Comment: Promethazine adverse events after implementation of a medication shortage interchange. 
  • Comparison of two knowledge bases on the detection of drug-drug interactions. 
  • Complementary and alternative medicine in cardiovascular disease: a review of biologically based approaches. 
  • Conditions that may affect the results of susceptibility testing of Mycobacterium tuberculosis to pyrazinamide. 
  • Conflicting results between randomized trials and observational studies on the impact of proton pump inhibitors on cardiovascular events when coadministered with dual antiplatelet therapy: systematic review. 
  • Critical care perspective on immunotherapy in lung transplantation. 
  • Cyclophosphamide, cisplatin, and carmustine: pharmacokinetics of carmustine following multiple alkylating-agent interactions. 
  • Cyclosporin A inhibits chromium(VI)-induced apoptosis and mitochondrial cytochrome c release and restores clonogenic survival in CHO cells. 
  • Cystine-glutamate transport interactions in rat renal cortical tubules, brushborder vesicles, and cultured renal tubule cells. 
  • D1 and D2 antagonists reverse the effects of appetite suppressants on weight loss, food intake, locomotion, and rebalance spiking inhibition in the rat NAc shell. 
  • D1 and D2 dopamine receptor interactions with pilocarpine-induced oral activity in rats. 
  • Depot medroxyprogesterone acetate in combination with a twice-daily lopinavir-ritonavir-based regimen in HIV-infected women showed effective contraception and a lack of clinically significant interactions, with good safety and tolerability: results of the ACTG 5283 study. 
  • Design, implementation and evaluation of a clinical decision support system to prevent adverse drug events. 
  • Desipramine toxicity with terbinafine. 
  • Dialogue with patient care organizations. 
  • Dialysate calcium concentration and the risk of sudden cardiac arrest in hemodialysis patients. 
  • Differential actions of diazepam and zolpidem in basolateral and central amygdala nuclei. 
  • Differential cardiac effects of growth hormone and insulin-like growth factor-1 in the rat. A combined in vivo and in vitro evaluation. 
  • Differential effects of triphenylphosphite and diisopropyl phosphorofluoridate on catecholamine secretion from bovine adrenomedullary chromaffin cells. 
  • Differential regulation of MeCP2 phosphorylation in the CNS by dopamine and serotonin. 
  • Differentiation of erythroleukemia cells in vitro: properties of chemical inducers. 
  • Does acute treatment with sedatives/hypnotics for anxiety in depressed patients affect suicide risk? A literature review. 
  • Does aspirin use adversely influence intermediate-term postdischarge outcomes for hospitalized patients who are treated with angiotensin-converting enzyme inhibitors or angiotensin receptor blockers? Findings from Organized Program to Facilitate Life-Saving Treatment in Hospitalized Patients with Heart Failure (OPTIMIZE-HF). 
  • Does the activity of the combination of imipenem and colistin in vitro exceed the problem of resistance in metallo-beta-lactamase-producing Klebsiella pneumoniae isolates? 
  • Dosing recommendations and prescribing patterns for depressed medically ill hospitalized older patients. 
  • Dronedarone and vitamin K antagonists: a review of drug-drug interactions. 
  • Drug interaction between carbapenems and extended-release divalproex sodium in a patient with schizoaffective disorder. 
  • Drug interactions between hormonal contraceptives and antiretrovirals. 
  • Drug interactions between non-rifamycin antibiotics and hormonal contraception: a systematic review. 
  • Drug interactions between rifamycin antibiotics and hormonal contraception: a systematic review. 
  • Drug interactions complicate antiplatelet therapy. 
  • Drug interactions: volatile anesthetics and opioids. 
  • Drug-drug interaction studies of cardiovascular drugs involving P-glycoprotein, an efflux transporter, on the pharmacokinetics of edoxaban, an oral factor Xa inhibitor. 
  • Drug-drug interactions in older adults: which ones matter? 
  • Effect of Intravenous Fentanyl on Ticagrelor Absorption and Platelet Inhibition Among Patients Undergoing Percutaneous Coronary Intervention: The PACIFY Randomized Clinical Trial (Platelet Aggregation With Ticagrelor Inhibition and Fentanyl). 
  • Effect of accompanying antiretroviral drugs on virological response to pegylated interferon and ribavirin in patients co-infected with HIV and hepatitis C virus. 
  • Effect of carbamazepine on Coumadin metabolism. 
  • Effect of colistin on phospholipid-based activated partial thromboplastin time clotting assay results in patients receiving concomitant heparin therapy. 
  • Effect of daily dosing duration of direct and indirect dopamine receptor agonists: cocaine cross-tolerance following chronic regimens. 
  • Effect of di(2-ethylhexyl) phthalate on DNA repair and lipid peroxidation in rat hepatocytes and on metabolic cooperation in Chinese hamster V-79 cells. 
  • Effect of low-dose aspirin on thromboxane production and the antihypertensive effect of captopril. 
  • Effect of ozone on drug-induced sleeping time in mice pretreated with mixed-function oxidase inducers and inhibitors. 
  • Effect of ritonavir-induced cytochrome P450 3A4 inhibition on plasma fentanyl concentrations during patient-controlled epidural labor analgesia: a pharmacokinetic simulation. 
  • Effect of simultaneous didanosine administration on itraconazole absorption in healthy volunteers. 
  • Effect of the bile acid sequestrant colesevelam on the pharmacokinetics of pioglitazone, repaglinide, estrogen estradiol, norethindrone, levothyroxine, and glyburide. 
  • Effect of tolcapone, a catechol-O-methyltransferase inhibitor, on striatal dopaminergic transmission during blockade of dopamine uptake. 
  • Effects of ZD6169, a K ATP channel opener, on neurally-mediated plasma extravasation in the rat urinary bladder induced by chemical or electrical stimulation of nerves. 
  • Effects of acute hypermagnesemia on the threshold for lidocaine-induced seizures in the rat. 
  • Effects of beta-endorphin on ornithine decarboxylase in tissues of developing rats: a potential role for this endogenous neuropeptide in the modulation of tissue growth. 
  • Effects of daily dermal application of DEET and epermethrin, alone and in combination, on sensorimotor performance, blood-brain barrier, and blood-testis barrier in rats. 
  • Effects of dopamine D1 and D2 receptor antagonists on oral activity in rats. 
  • Effects of gamma hydroxybutyric acid on inhibition and excitation in rat neocortex. 
  • Effects of glutathione on chromium-induced DNA crosslinking and DNA polymerase arrest. 
  • Effects of reserpine on the content and properties of rat adrenal medullary storage vesicles. 
  • Effects of ritonavir-boosted lopinavir on the pharmacokinetics of quinine. 
  • Effects of sazetidine-A, a selective α4β2* nicotinic receptor desensitizing agent, on body temperature regulation in mice and rats. 
  • Effects of single and combined exposures to benzo(a)pyrene and 3,3'4,4'5-pentachlorobiphenyl on EROD activity and development in Fundulus heteroclitus. 
  • Effects of the polycyclic aromatic hydrocarbon heterocycles, carbazole and dibenzothiophene, on in vivo and in vitro CYP1A activity and polycyclic aromatic hydrocarbon-derived embryonic deformities. 
  • Effects of tobacco smoking and nicotine on cancer treatment. 
  • Efficacy and safety of St. John's wort for the treatment of major depression. 
  • Efficacy and safety of angiotensin receptor blockade are not modified by aspirin in patients with chronic heart failure: a cohort study from the Candesartan in Heart failure--Assessment of Reduction in Mortality and morbidity (CHARM) programme. 
  • Elevated mu-opioid receptor expression in the nucleus of the solitary tract accompanies attenuated withdrawal signs after chronic low dose naltrexone in opiate-dependent rats. 
  • Enfuvirtide: the first therapy to inhibit the entry of HIV-1 into host CD4 lymphocytes. 
  • Enhancement of irinotecan (CPT-11) activity against central nervous system tumor xenografts by alkylating agents. 
  • Epidemiology of drug-disease interactions in older veteran nursing home residents. 
  • Erythromycin-induced carbamazepine toxicity: a continuing problem. 
  • Establishment of a melphalan-resistant rhabdomyosarcoma xenograft with cross-resistance to vincristine and enhanced sensitivity following buthionine sulfoximine-mediated glutathione depletion. 
  • Estradiol replacement enhances cocaine-stimulated locomotion in female C57BL/6 mice through estrogen receptor alpha. 
  • Ethanol and magnesium ions inhibit N-methyl-D-aspartate-mediated synaptic potentials in an interactive manner. 
  • Evaluation of psychopharmacological effects of Clerodendrum phlomidis Linn. extract. 
  • Evaluation of the dofetilide risk-management program. 
  • Evaluation of the pharmacokinetic drug interaction potential of tivantinib (ARQ 197) using cocktail probes in patients with advanced solid tumours. 
  • Executive summary. Management of urinary tract infection in solid organ transplant recipients: Consensus statement of the Group for the Study of Infection in Transplant Recipients (GESITRA) of the Spanish Society of Infectious Diseases and Clinical Microbiology (SEIMC) and the Spanish Network for Research in Infectious Diseases (REIPI). 
  • Exercise biology and medicine: innovative research to improve global health. 
  • Facilitation of granule cell epileptiform activity by mossy fiber-released zinc in the pilocarpine model of temporal lobe epilepsy. 
  • Fast endocytosis is inhibited by GABA-mediated chloride influx at a presynaptic terminal. 
  • Febuxostat: a new agent for lowering serum urate. 
  • Fludarabine with a higher versus lower dose of myeloablative timed-sequential busulfan in older patients and patients with comorbidities: an open-label, non-stratified, randomised phase 2 trial. 
  • Flunarizine enhancement of melphalan activity against drug-sensitive/resistant rhabdomyosarcoma. 
  • Frequency of high-risk use of QT-prolonging medications. 
  • GSNO reductase and beta2-adrenergic receptor gene-gene interaction: bronchodilator responsiveness to albuterol. 
  • Glycine receptor antagonism. Effects of ACEA-1021 on the minimum alveolar concentration for halothane in the rat. 
  • Guidance on the emergent reversal of oral thrombin and factor Xa inhibitors. 
  • Guidelines for the diagnosis and treatment of non-ST-segment elevation acute coronary syndromes. 
  • Heparinase I (neutralase) reversal of systemic anticoagulation. 
  • Histamine H1 receptor involvement in prepulse inhibition and memory function: relevance for the antipsychotic actions of clozapine. 
  • How important are drug-drug interactions to the health of older adults? 
  • How to manage drug interactions. 
  • Ibrutinib: a new targeted therapy for hematologic cancers. 
  • Imbalances emerge in cardiac autonomic cell signaling after neonatal exposure to terbutaline or chlorpyrifos, alone or in combination. 
  • Immediate and delayed neurotoxicity after mechlorethamine preparation for bone marrow transplantation. 
  • Immunostimulatory properties of genomic DNA from different bacterial species. 
  • Impact of inappropriate drug use on health services utilization among representative older community-dwelling residents. 
  • Impact of morphine on antiplatelet effects of oral P2Y12 receptor inhibitors. 
  • Importance of potent P2Y(12) receptor blockade in acute myocardial infarction: focus on prasugrel. 
  • Improving neutralization potency and breadth by combining broadly reactive HIV-1 antibodies targeting major neutralization epitopes. 
  • In vitro interactions between antifungals and immunosuppressants against Aspergillus fumigatus. 
  • In vitro metabolism and interactions of pyridostigmine bromide, N,N-diethyl-m-toluamide, and permethrin in human plasma and liver microsomal enzymes. 
  • Incidence and predictors of all and preventable adverse drug reactions in frail elderly persons after hospital stay. 
  • Incidence of caffeine in serum of patients undergoing dipyridamole myocardial perfusion stress test by an intensive versus routine caffeine history screening. 
  • Increased expression of glial fibrillary acidic protein in cerebellum and hippocampus: differential effects on neonatal brain regional acetylcholinesterase following maternal exposure to combined chlorpyrifos and nicotine. 
  • Increased melphalan activity in intracranial human medulloblastoma and glioma xenografts following buthionine sulfoximine-mediated glutathione depletion. 
  • Increased neurotoxicity following concurrent exposure to pyridostigmine bromide, DEET, and chlorpyrifos. 
  • Individual Proton Pump Inhibitors and Outcomes in Patients With Coronary Artery Disease on Dual Antiplatelet Therapy: A Systematic Review. 
  • Induction of urinary excretion of 3-nitrotyrosine, a marker of oxidative stress, following administration of pyridostigmine bromide, DEET (N,N-diethyl-m-toluamide) and permethrin, alone and in combination in rats. 
  • Infection and cyclosporine. 
  • Influence of DMSO on antifungal activity during susceptibility testing in vitro. 
  • Influence of Successful Chronic Hepatitis C Virus Treatment with Ledipasvir/Sofosbuvir on Warfarin Dosing Requirements in Four Veterans. 
  • Influence of diagnostic and treatment factors in the population pharmacokinetics of gentamicin. 
  • Influence of ozone on pentobarbital pharmacokinetics in mice. 
  • Interacting medication use and the treatment effects of apixaban versus warfarin: results from the ARISTOTLE Trial. 
  • Interaction between disopyramide and practolol. 
  • Interaction of endosulfan and dietary vitamin A on rat hepatic drug metabolising enzymes. 
  • Interaction of ibuprofen and warfarin on primary haemostasis. 
  • Interaction of pyridostigmine bromide and N,N-diethyl-m-toluamide alone and in combination with P-glycoprotein expressed in Escherichia coli leaky mutant. 
  • Interaction of vitamin A and cortisol on liver and plasma lipids of rats. 
  • Interactions between NMDA and AMPA glutamate receptor antagonists during halothane anesthesia in the rat. 
  • Interactions between heparins, glycoprotein IIb/IIIa antagonists, and coronary intervention. The Global Registry of Acute Coronary Events (GRACE). 
  • Interactions of vasoactive intestinal polypeptide and cholecystokinin octapeptide on the control of gallbladder contraction. 
  • Interleukin-1beta inhibits gamma-aminobutyric acid type A (GABA(A)) receptor current in cultured hippocampal neurons. 
  • Investigations on the antihypertensive activity of timolol and bendroflumethiazide and the combination in dogs and rats. 
  • Is bleeding a necessary evil? The inherent risk of antithrombotic pharmacotherapy used for stroke prevention in atrial fibrillation. 
  • Ischemic depolarization during halothane-nitrous oxide and isoflurane-nitrous oxide anesthesia. An examination of cerebral blood flow threshold and times to depolarization. 
  • Isoflurane alters the kinetics of oral cyclosporine. 
  • Isoproterenol inhibits the increase in microvascular membrane permeability produced by bradykinin. 
  • Ketanserin attenuates nicotine-induced working memory improvement in rats. 
  • Lack of disulfiram--like reactions with ceftizoxime. 
  • Lack of effect of ondansetron on the pharmacokinetics and analgesic effects of morphine and metabolites after single-dose morphine administration in healthy volunteers. 
  • Lactogenic and somatogenic hormones regulate the expression of neuropeptide Y and cocaine- and amphetamine-regulated transcript in rat insulinoma (INS-1) cells: interactions with glucose and glucocorticoids. 
  • Leptin mediates the parathyroid hormone-related protein paracrine stimulation of fetal lung maturation. 
  • Leptin opposes insulin's effects on fatty acid partitioning in muscles isolated from obese ob/ob mice. 
  • Limitations of a simplification antiretroviral strategy for HIV-infected patients with decreasing adherence to a protease inhibitor regimen. 
  • Liver transplantation in HIV/hepatitis co-infection. 
  • Locomotor and sensorimotor performance deficit in rats following exposure to pyridostigmine bromide, DEET, and permethrin, alone and in combination. 
  • Lovastatin and coadministered antihypertensive/cardiovascular agents. 
  • Magnesium sulfate inhibits the oxytocin-induced production of inositol 1,4,5-trisphosphate in cultured human myometrial cells. 
  • Magnitude and ethanol sensitivity of tonic GABAA receptor-mediated inhibition in dentate gyrus changes from adolescence to adulthood. 
  • Management of drug and food interactions with azole antifungal agents in transplant recipients. 
  • Management of patients coinfected with HCV and HIV: a close look at the role for direct-acting antivirals. 
  • Management of platelet-directed pharmacotherapy in patients with atherosclerotic coronary artery disease undergoing elective endoscopic gastrointestinal procedures. 
  • Management of urinary tract infection in solid organ transplant recipients: Consensus statement of the Group for the Study of Infection in Transplant Recipients (GESITRA) of the Spanish Society of Infectious Diseases and Clinical Microbiology (SEIMC) and the Spanish Network for Research in Infectious Diseases (REIPI). 
  • Maternal cadmium, iron and zinc levels, DNA methylation and birth weight. 
  • Medical management of adrenal cortical disease. 
  • Medroxyprogesterone acetate levels among Kenyan women using depot medroxyprogesterone acetate in the FEM-PrEP trial. 
  • Metformin Use May Moderate the Effect of DPP-4 Inhibitors on Cardiovascular Outcomes. 
  • Microdialysis studies on the action of tolcapone on pharmacologically-elevated extracellular dopamine levels in conscious rats. 
  • Microdosing and drug development: past, present and future. 
  • Milnacipran: beyond a role of antidepressant. 
  • Mitogenesis, cell migration, and loss of focal adhesions induced by tenascin-C interacting with its cell surface receptor, annexin II. 
  • Modafinil and cocaine interactions. 
  • Modeling the developmental neurotoxicity of nicotine in vitro: cell acquisition, growth and viability in PC12 cells. 
  • Modulating role of lithium on dopamine turnover, prolactin release, and behavioral supersensitivity following haloperidol and reserpine. 
  • Modulation of ATP-induced calcium signaling by progesterone in T47D-Y breast cancer cells. 
  • Multifactorial optimization of endothelial cell growth using modular synthetic extracellular matrices. 
  • Muscarinic inhibition of substance P induced ion secretion in piglet jejunum. 
  • N-acetylcysteine does not modify nitroglycerin-induced tolerance in canine vascular rings. 
  • National Academy of Clinical Biochemistry Laboratory Medicine practice guidelines: Clinical utilization of cardiac biomarker testing in heart failure. 
  • Ncm-D-aspartate: a novel caged D-aspartate suitable for activation of glutamate transporters and N-methyl-D-aspartate (NMDA) receptors in brain tissue. 
  • Neuregulin-1 enhances depolarization-induced GABA release. 
  • Neurosteroid modulation of GABAergic neurotransmission in the central amygdala: a role for NMDA receptors. 
  • Neurotensin reduces glutamatergic transmission in the dorsolateral striatum via retrograde endocannabinoid signaling. 
  • Nevirapine-based antiretroviral therapy does not reduce oral contraceptive effectiveness. 
  • Nicotine inhibits voltage-dependent sodium channels and sensitizes vanilloid receptors. 
  • Nicotine interactions with haloperidol, clozapine and risperidone and working memory function in rats. 
  • Nicotine interactions with low-dose alcohol: pharmacological influences on smoking and drinking motivation. 
  • Nicotine-alcohol interactions and attentional performance on an operant visual signal detection task in female rats. 
  • Nicotine-antipsychotic drug interactions and attentional performance in female rats. 
  • Nicotine-dizocilpine interactions and working and reference memory performance of rats in the radial-arm maze. 
  • Nicotinic and muscarinic interactions and choice accuracy in the radial-arm maze. 
  • Nicotinic antagonist effects in the mediodorsal thalamic nucleus: regional heterogeneity of nicotinic receptor involvement in cognitive function. 
  • Nicotinic interactions with antipsychotic drugs, models of schizophrenia and impacts on cognitive function. 
  • Nicotinic-antipsychotic drug interactions and cognitive function. 
  • Nicotinic-glutamatergic interactions and attentional performance on an operant visual signal detection task in female rats. 
  • Nicotinic-serotonergic drug interactions and attentional performance in rats. 
  • Ofloxacin: its pharmacology, pharmacokinetics, and potential for clinical application. 
  • Olanzapine interactions with nicotine and mecamylamine in rats: effects on memory function. 
  • Ondansetron given in the acute withdrawal from a repeated cocaine sensitization dosing regimen reverses the expression of sensitization and inhibits self-administration. 
  • Opposite effects of lead on chemical carcinogenesis in kidney and liver of rats. 
  • Oral anticoagulants for stroke prevention in atrial fibrillation: current status, special situations, and unmet needs. 
  • Oral anticoagulants in older adults with atrial fibrillation. 
  • Oral poly(ADP-ribose) polymerase-1 inhibitor BSI-401 has antitumor activity and synergizes with oxaliplatin against pancreatic cancer, preventing acute neurotoxicity. 
  • Oxidative mechanisms contributing to the developmental neurotoxicity of nicotine and chlorpyrifos. 
  • PA tablets: investigational compounds combining aspirin and omeprazole for cardioprotection. 
  • PI3 kinase is involved in cocaine behavioral sensitization and its reversal with brain area specificity. 
  • Paradoxical intraocular pressure elevation after combined therapy with latanoprost and bimatoprost. 
  • Paroxetine: safety and tolerability issues. 
  • Pediatric invasive aspergillosis. 
  • Pegloticase for treating refractory chronic gout. 
  • Perfluorooctyl bromide (perflubron) attenuates oxidative injury to biological and nonbiological systems. 
  • Pergolide interactions with nicotine and pilocarpine in rats on the radial-arm maze. 
  • Periischemic cerebral blood flow (CBF) does not explain beneficial effects of isoflurane on outcome from near-complete forebrain ischemia in rats. 
  • Pharmacodynamic evaluation of clopidogrel plus PA32540: the Spaced PA32540 With Clopidogrel Interaction Gauging (SPACING) study. 
  • Pharmacogenomics for personalized pain medicine. 
  • Pharmacokinetic and pharmacodynamic characteristics of medications used for moderate sedation. 
  • Pharmacokinetic effect of AMD070, an Oral CXCR4 antagonist, on CYP3A4 and CYP2D6 substrates midazolam and dextromethorphan in healthy volunteers. 
  • Pharmacokinetic interactions and safety evaluations of coadministered tafenoquine and chloroquine in healthy subjects. 
  • Pharmacokinetic interactions between depot medroxyprogesterone acetate and combination antiretroviral therapy. 
  • Pharmacokinetic/pharmacodynamic interactions of intensive cyclophosphamide, cisplatin, and BCNU in patients with breast cancer. 
  • Pharmacokinetics and pharmacodynamics of ticagrelor in patients with stable coronary artery disease: results from the ONSET-OFFSET and RESPOND studies. 
  • Pharmacokinetics of amlodipine and olmesartan after administration of amlodipine besylate and olmesartan medoxomil in separate dosage forms and as a fixed-dose combination. 
  • Pharmacokinetics of antiretroviral regimens containing tenofovir disoproxil fumarate and atazanavir-ritonavir in adolescents and young adults with human immunodeficiency virus infection. 
  • Pharmacokinetics of levetiracetam. 
  • Pharmacokinetics of once-daily IV busulfan as part of pretransplantation preparative regimens: a comparison with an every 6-hour dosing schedule. 
  • Pharmacological evaluation of central adrenergic involvement in chlordecone-induced hypothermia. 
  • Pharmacology and clinical applications of human recombinant antithrombin. 
  • Phase I study of SU5416, a small molecule inhibitor of the vascular endothelial growth factor receptor (VEGFR) in refractory pediatric central nervous system tumors. 
  • Phase I/II study of the P-glycoprotein modulator PSC 833 in patients with acute myeloid leukemia. 
  • Phenamil: an irreversible inhibitor of sodium channels in the toad urinary bladder. 
  • Polyamines antagonize N-methyl-D-aspartate-evoked depolarizations, but reduce Mg2+ block. 
  • Polypharmacy management in Medicare managed care: changes in prescribing by primary care physicians resulting from a program promoting medication reviews. 
  • Posaconazole's impact on prophylaxis and treatment of invasive fungal infections: an update. 
  • Postischemic nitrous oxide alone versus intraischemic nitrous oxide in the presence of isoflurane: what it may change for neuroprotection against cerebral stroke in the rat. 
  • Postsynaptic mechanisms govern the differential excitation of cortical neurons by thalamic inputs. 
  • Postsynaptic requirement for Abl kinases in assembly of the neuromuscular junction. 
  • Potency of combined estrogenic pesticides. 
  • Potential interactions between GABAb and cholinergic systems: baclofen augments scopolamine-induced performance deficits in the eight-arm radial maze. 
  • Potential kidney toxicity from the antiviral drug tenofovir: new indications, new formulations, and a new prodrug. 
  • Practical aspects of MAO inhibitor therapy. 
  • Preclinical evaluation of gemcitabine combination regimens for application in acute myeloid leukemia. 
  • Prediction in drug abuse: cocaine interactions with alcohol and buprenorphine. 
  • Preliminary study of quinine pharmacokinetics in pregnant women with malaria-HIV co-infection. 
  • Prenatal nicotine changes the response to postnatal chlorpyrifos: Interactions targeting serotonergic synaptic function and cognition. 
  • Protein kinase C inhibition by tamoxifen antagonizes manic-like behavior in rats: implications for the development of novel therapeutics for bipolar disorder. 
  • Protein levels of neurofilament subunits in the hen central nervous system following prevention and potentiation of diisopropyl phosphorofluoridate (DFP)-induced delayed neurotoxicity(1). 
  • Psychopharmacological interactions between nicotine and ethanol. 
  • Psychophysiological interactions between caffeine and nicotine. 
  • Psychotherapeutic agents in older adults. Metabolism, bioavailability, and drug interactions. 
  • Quality of pharmacotherapy and outcomes for older veterans discharged from the emergency department. 
  • Quenching of DNA cross-link precursors of chloroethylnitrosoureas and attenuation of DNA interstrand cross-linking by glutathione. 
  • Radial-arm maze performance in rats is impaired by a combination of nicotinic-cholinergic and D2 dopaminergic antagonist drugs. 
  • Randomized comparison of direct thrombin inhibition versus heparin in conjunction with fibrinolytic therapy for acute myocardial infarction: results from the GUSTO-IIb Trial. Global Use of Strategies to Open Occluded Coronary Arteries in Acute Coronary Syndromes (GUSTO-IIb) Investigators. 
  • Rational theophylline use in older asthmatics. 
  • Reboxetine: a selective norepinephrine reuptake inhibitor for the treatment of depression. 
  • Regional differences in the management and outcome of kidney transplantation in patients with human immunodeficiency virus infection: A 3-year retrospective cohort study. 
  • Regulation of beta adrenergic receptors in isolated frog erythrocyte plasma membranes. 
  • Relationship between dietary retinol and lipofuscin in the retinal pigment epithelium. 
  • Reliability of a modified medication appropriateness index in ambulatory older persons. 
  • Research Priorities to Advance the Health and Health Care of Older Adults with Multiple Chronic Conditions. 
  • Restorative effects of GDNF on striatal dopamine release in rats treated with neurotoxic doses of methamphetamine. 
  • Reversal of a mecamylamine-induced cognitive deficit with the D2 agonist, LY 171555. 
  • Reversal of physiological stress-induced resistance to topoisomerase II inhibitors using an inducible phosphorylation site-deficient mutant of I kappa B alpha. 
  • Risk of adverse outcomes associated with concomitant use of clopidogrel and proton pump inhibitors following acute coronary syndrome. 
  • Role of C-terminal serines in desensitization and phosphorylation of the mouse thromboxane receptor. 
  • Role of the GLT-1 subtype of glutamate transporter in glutamate homeostasis: the GLT-1-preferring inhibitor WAY-855 produces marginal neurotoxicity in the rat hippocampus. 
  • Roundtable panel discussion: the role of glycoprotein IIb-IIIa receptor inhibitors in acute ischemic coronary syndromes. 
  • Safety considerations in the use of drug combinations during general anaesthesia. 
  • Safety events in kidney transplant recipients: results from the folic Acid for vascular outcome reduction in transplant trial. 
  • Safety of aprotinin in heparinized and nonheparinized patients. 
  • Safety of selegiline transdermal system in clinical practice: analysis of adverse events from postmarketing exposures. 
  • Sazetidine-A, a selective α4β2 nicotinic acetylcholine receptor ligand: effects on dizocilpine and scopolamine-induced attentional impairments in female Sprague-Dawley rats. 
  • Schizophrenia, drug therapy, and monitoring. 
  • Selective activation of cannabinoid CB(2) receptors suppresses spinal fos protein expression and pain behavior in a rat model of inflammation. 
  • Selective inhibition of adenylyl cyclase type V by the dopamine D3 receptor. 
  • Selective mechanism-based inactivation of CYP3A4 by CYP3cide (PF-04981517) and its utility as an in vitro tool for delineating the relative roles of CYP3A4 versus CYP3A5 in the metabolism of drugs. 
  • Selective serotonin 5-HT3 receptor antagonists for postoperative nausea and vomiting: are they all the same? 
  • Sensorimotor deficit and cholinergic changes following coexposure with pyridostigmine bromide and sarin in rats. 
  • Sensorimotor deficits and increased brain nicotinic acetylcholine receptors following exposure to chlorpyrifos and/or nicotine in rats. 
  • Serotonin syndrome in a chronic-pain patient receiving concurrent methadone, ciprofloxacin, and venlafaxine. 
  • Serotonin-lesion myoclonic syndromes. I. Neurochemical profile and S-1 receptor binding. 
  • Sex-related differences in clinical drug response: implications for women's health. 
  • Sex-related spatial learning differences after prenatal cocaine exposure in the young adult rat. 
  • Simultaneous determination of malathion, permethrin, DEET (N,N-diethyl-m-toluamide), and their metabolites in rat plasma and urine using high performance liquid chromatography. 
  • St. John's wort (Hypericum perforatum): a review of the current pharmacological, toxicological, and clinical literature. 
  • Statin therapy--Part II: Clinical considerations for cardiovascular disease. 
  • Statins do not affect platelet inhibition with clopidogrel during coronary stenting. 
  • Suboptimal prescribing in older inpatients and outpatients. 
  • Successful pregnancy after orthotopic liver transplantation in a patient with HIV infection. 
  • Survey of methadone-drug interactions among patients of methadone maintenance treatment program in Taiwan. 
  • Susceptibility of Aspergillus to 5-fluorocytosine and amphotericin B alone and in combination. 
  • Swainsonine protects both murine and human haematopoietic systems from chemotherapeutic toxicity. 
  • Symposium overview: mechanism of action of nicotine on neuronal acetylcholine receptors, from molecule to behavior. 
  • Symptom exacerbation in psychotically depressed adolescents due to high desipramine plasma concentrations. 
  • Synergistic embryotoxicity of polycyclic aromatic hydrocarbon aryl hydrocarbon receptor agonists with cytochrome P4501A inhibitors in Fundulus heteroclitus. 
  • Tamoxifen pharmacogenomics: the role of CYP2D6 as a predictor of drug response. 
  • Temporary disruption of the rat blood-brain barrier with a monoclonal antibody: a novel method for dynamic manganese-enhanced MRI. 
  • The Impact of Pharmacokinetic Interactions With Eslicarbazepine Acetate Versus Oxcarbazepine and Carbamazepine in Clinical Practice. 
  • The additive interactions between ondansetron and droperidol for preventing postoperative nausea and vomiting. 
  • The anticoagulated patient: strategies for effective blood loss management. 
  • The capsaicin VR1 receptor mediates substance P release in toxin A-induced enteritis in rats. 
  • The clinical management of HCV in the HIV-infected patient. 
  • The clinical pharmacogenetics implementation consortium guideline for SLCO1B1 and simvastatin-induced myopathy: 2014 update. 
  • The clopidogrel-statin interaction. 
  • The convergence of herb pharmacodynamics and herb-drug interactions on hemostasis. 
  • The drug-drug interaction between proton pump inhibitors and clopidogrel. 
  • The effect of active site-inhibited factor VIIa on tissue factor-initiated coagulation using platelets before and after aspirin administration. 
  • The effect of antibiotic additions on the mechanical properties of acrylic cement. 
  • The effect of aprepitant and race on the pharmacokinetics of cyclophosphamide in breast cancer patients. 
  • The effect of endothelin-1 on muscle microcirculation and its attenuation by verapamil. 
  • The effect of quinidine, propranolol and their combination on experimental atrial and ventricular arrhythmias. 
  • The effect of the interaction of propofol and alfentanil on recall, loss of consciousness, and the Bispectral Index. 
  • The effects of MDCO-2010, a serine protease inhibitor, on activated clotting time in blood obtained from volunteers and cardiac surgical patients. 
  • The interaction of escitalopram and R-citalopram at the human serotonin transporter investigated in the mouse. 
  • The interplay of prolactin and the glucocorticoids in the regulation of beta-cell gene expression, fatty acid oxidation, and glucose-stimulated insulin secretion: implications for carbohydrate metabolism in pregnancy. 
  • The lack of involvement of cyclic nucleotides in the smooth muscle relaxant action of BRL 34915. 
  • The newer antiepileptic drugs: carbamazepine and valproic acid. 
  • The non-covalent interaction of pyrrolo[2, 1-c] [1, 4]benzodiazepine-5, 11-diones with DNA. 
  • The novel combination of theophylline and bambuterol as a potential treatment of hypoxemia in humans. 
  • The pharmacokinetics of timegadine and two of its metabolites after multiple oral dosing, and the effects of concomitant administration of ibuprofen. 
  • The products of the reaction between toluene diisocyanate and water contract isolated guinea pig bronchi. 
  • The quality of pharmacotherapy in older veterans discharged from the emergency department or urgent care clinic. 
  • The relation of quinidine-induced elevation of serum digoxin concentration to the conversion of atrial fibrillation-flutter: a pilot study. 
  • The response to inhaled nitric oxide in patients with pulmonary artery hypertension is not masked by baseline vasodilator use. 
  • The role of alpha7 and alpha4beta2 nicotinic receptors in the nicotine-induced anxiolytic effect in zebrafish. 
  • The sea urchin embryo, an invertebrate model for mammalian developmental neurotoxicity, reveals multiple neurotransmitter mechanisms for effects of chlorpyrifos: therapeutic interventions and a comparison with the monoamine depleter, reserpine. 
  • The time course of protection from delayed neurotoxicity induced by tri-o-cresyl phosphate and O,O-diisopropyl phosphorofluoridate by phenyl methyl sulfonyl fluoride in chickens. 
  • The vulnerable endothelium: priming the vascular endothelium for thrombosis with unfractionated heparin: biologic plausibility for observations from the Superior Yield of the New Strategy of Enoxaparin, Revascularization and GlYcoprotein IIb/IIIa Inhibitors (SYNERGY) trial. 
  • The α₂-adrenergic antagonist idazoxan counteracts prepulse inhibition deficits caused by amphetamine or dizocilpine in rats. 
  • Thrombin enhances monocyte secretion of tumor necrosis factor and interleukin-1 beta by two distinct mechanisms. 
  • Tolvaptan administration does not affect steady state amiodarone concentrations in patients with cardiac arrhythmias. 
  • Transdermal selegiline. 
  • Transdermal selegiline: the new generation of monoamine oxidase inhibitors. 
  • Transient increase in plasma quinidine concentrations during ketoconazole-quinidine therapy. 
  • Transiently overexpressed alpha2-adrenoceptors and their control of DNA synthesis in the developing brain. 
  • Treatment considerations for patients with neuropathic pain and other medical comorbidities. 
  • Treatment of hypertension in patients with comorbidities: results from the study of hypertensive prescribing practices (SHyPP). 
  • Treatment options for invasive fungal infections. 
  • Tricyclic-induced akathisia in patients taking conjugated estrogens. 
  • Triphenyl phosphite neurotoxicity in the hen: inhibition of neurotoxic esterase and of prophylaxis by phenylmethylsulfonyl fluoride. 
  • Tuberculosis treatment and risk of stavudine substitution in first-line antiretroviral therapy. 
  • Type 2 diabetes. How new insights, new drugs are changing clinical practice. 
  • Understanding therapeutic equivalence in epilepsy. 
  • Usability of mobile technology to screen for drug-drug interactions in kidney transplant patients. 
  • Use of control steady-state serum digoxin levels for predicting serum digoxin concentration after quinidine administration. 
  • Use of sildenafil (Viagra) in patients with cardiovascular disease. Technology and Practice Executive Committee. 
  • Ventral hippocampal NMDA blockade and nicotinic effects on memory function. 
  • Ventral hippocampal ibotenic acid lesions block chronic nicotine-induced spatial working memory improvement in rats. 
  • Virologic failure in therapy-naive subjects on aplaviroc plus lopinavir-ritonavir: detection of aplaviroc resistance requires clonal analysis of envelope. 
  • Warfarin and acetaminophen interaction: a summary of the evidence and biologic plausibility. 
  • Warfarin reversal with prothrombin complex concentrate confers better antifibrinolytic activity compared with recombinant activated factor VII. 
  • What clinicians should know about the QT interval. 
  • What is the role of combination drug therapy in the treatment of overactive bladder? ICI-RS 2014. 
  • [Characteristics of hepatitis and influenza antivirals: update 2009]. 
  • [Liver transplantation in patients with HIV infection: a reality in 2004]. 
  • [Pharmacological modulation of dopaminergic transmission in the rat striatum in vivo]. 
  • [Renal transplantation in patients with HIV infection]. 
  • [The effect of the dopamine neuronal reuptake inhibitor GBR 12909 on the dopaminergic neurotransmission parameters in the rat striatum in vivo] 
  • rHuEPO and improved treatment outcomes: potential modes of action. 
  • tPA-mediated generation of plasmin is catalyzed by the proteoglycan NG2. 
• 

  Keywords of People

  • Curtis, Lesley H., Professor in Population Health Sciences, Medicine, General Internal Medicine
  • Erickson, Harold Paul, James B. Duke Professor of Cell Biology, Biomedical Engineering
  • Freemark, Michael Scott, Robert C. Atkins, M.D. and Veronica Atkins Professor of Pediatrics, in the School of Medicine, Pediatrics, Endocrinology
  • McDonnell, Donald Patrick, Chair, Department of Pharmacology & Cancer Biology, Duke Innovation & Entrepreneurship
  • Middleton, John Paul, Associate Professor of Medicine, Medicine, Nephrology
  • O'Connor, Christopher Michael, Richard Sean Stack, M.D. / Guidant Foundation Professor of Cardiology, Medicine, Clinical Pharmacology
  • Warner, David Samuel, Distinguished Professor of Anesthesiology, in the School of Medicine, Neurobiology
  • Wu, Li-Tzy, Professor in Psychiatry and Behavioral Sciences, Medicine, General Internal Medicine