Drug Resistance, Microbial

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  Subject Areas on Research

  • A STE12 homolog is required for mating but dispensable for filamentation in candida lusitaniae. 
  • A comparative study of the mannose-resistant and mannose-sensitive haemagglutinins of Escherichia coli isolated from urinary tract infections. 
  • A new dominant selectable marker for use in Cryptococcus neoformans. 
  • A new face of the Rhesus antigen. 
  • A practical guide for the diagnosis and treatment of acute sinusitis. 
  • A structure-based mechanism for drug binding by multidrug transporters. 
  • A survey of crop-derived transgenes in activated and digester sludges in wastewater treatment plants in the United States. 
  • Acyclovir-resistant herpes simplex virus keratouveitis after penetrating keratoplasty. 
  • Addressing Antimicrobial Resistance and Stewardship: The Priority Antimicrobial Value and Entry (PAVE) Award. 
  • Allelic variants of the human glutathione S-transferase P1 gene confer differential cytoprotection against anticancer agents in Escherichia coli. 
  • An evaluation of the Duke criteria in 25 pathologically confirmed cases of prosthetic valve endocarditis. 
  • Anaerobic resistance of clinical isolates of Staphylococcus aureus to aminoglycosides. 
  • Analysis of bacterial cultures in infectious keratitis, 1997 to 2004. 
  • Analysis of trends in antimicrobial resistance patterns among clinical isolates of Bacteroides fragilis group species from 1990 to 1994. 
  • Antibiotic prophylaxis in interventional radiology. 
  • Antibiotic prophylaxis in vascular and interventional radiology. 
  • Antibiotic resistance in urinary isolates of Escherichia coli from college women with urinary tract infections. 
  • Antibiotic resistance needs global solutions. 
  • Antibiotic resistance: what is the impact of agricultural uses of antibiotics on children's health? 
  • Antibiotic-loaded bone cement for infection prophylaxis in total joint replacement. 
  • Antibiotics for acute bronchitis. 
  • Antifungal effects of cyclosporine and FK 506 are mediated via immunophilin-dependent calcineurin inhibition. 
  • Antifungal resistance trends towards the year 2000. Implications for therapy and new approaches. 
  • Antimicrobial Stewardship and Infection Prevention-Leveraging the Synergy: A Position Paper Update. 
  • Antimicrobial nanotechnology: its potential for the effective management of microbial drug resistance and implications for research needs in microbial nanotoxicology. 
  • Antimicrobial stewardship: another focus for patient safety? 
  • Antimicrobial susceptibilities of 1,292 isolates of the Bacteroides fragilis group in the United States: comparison of 1981 with 1982. 
  • Antimicrobial susceptibilities of group B streptococci isolated from patients with invasive disease: 10-year perspective. 
  • Antimicrobial susceptibility patterns of the Bacteroides fragilis group in the United States, 1989. 
  • Application of antimicrobial stewardship to optimise management of community acquired pneumonia. 
  • Appropriate use of antibiotics in serious obstetric and gynecologic infections. 
  • Bacteriophage T4 DNA topoisomerase is the target of antitumor agent 4'-(9-acridinylamino)methanesulfon-m-anisidide (m-AMSA) in T4-infected Escherichia coli. 
  • Calcineurin is essential for survival during membrane stress in Candida albicans. 
  • Calcineurin is essential in cyclosporin A- and FK506-sensitive yeast strains. 
  • Calcineurin is required for virulence of Cryptococcus neoformans. 
  • Can the thymus win the battle against drug-resistant HIV? 
  • Caspofungin for the treatment of azole resistant candidemia in a premature infant. 
  • Clarithromycin treatment for Mycobacterium avium-intracellulare complex lung disease. 
  • Classification and genetic characterization of pattern-forming Bacilli. 
  • Clinical practice guideline: management of sinusitis. 
  • Clonal and spontaneous origins of fluconazole resistance in Candida albicans. 
  • Coagulase-negative staphylococcal prosthetic valve endocarditis--a contemporary update based on the International Collaboration on Endocarditis: prospective cohort study. 
  • Colonial morphology of staphylococci on Memphis agar: phase variation of slime production, resistance to beta-lactam antibiotics, and virulence. 
  • Combined activity of amphotericin B and 5-fluorocytosine against Cryptococcus neoformans in vitro and in vivo in mice. 
  • Comparative activities of newer beta-lactam agents against members of the Bacteroides fragilis group. 
  • Comparison of direct and standard antimicrobial disk susceptibility testing for bacteria isolated from blood. 
  • Control of diarrhoeal diseases. 
  • Correlation of in vitro fluconazole resistance of Candida isolates in relation to therapy and symptoms of individuals seropositive for human immunodeficiency virus type 1. 
  • Cyclocreatine (1-carboxymethyl-2-iminoimidazolidine) inhibits the replication of human herpes viruses. 
  • Cycloheximide-resistant temperature-sensitive lethal mutations of Saccharomyces cerevisiae. 
  • DHFR/MSH3 amplification in methotrexate-resistant cells alters the hMutSalpha/hMutSbeta ratio and reduces the efficiency of base-base mismatch repair. 
  • Deletion analysis of bacteriophage T4 tertiary origins. A promoter sequence is required for a rifampicin-resistant replication origin. 
  • Development of Saccharomyces cerevisiae as a model pathogen. A system for the genetic identification of gene products required for survival in the mammalian host environment. 
  • Development of a standardized screening method for detection of vancomycin-resistant enterococci. 
  • Development of interpretive criteria and quality control limits for macrolide and clindamycin susceptibility testing of Streptococcus pneumoniae. 
  • Development of positive selectable markers for the fungal pathogen Cryptococcus neoformans. 
  • Development of resistance in Pseudomonas aeruginosa to imipenem, norfloxacin, and ciprofloxacin during therapy: proof provided by typing with a DNA probe. 
  • Differential effects of levofloxacin and ciprofloxacin on the risk for isolation of quinolone-resistant Pseudomonas aeruginosa. 
  • Direct allelic variation scanning of the yeast genome. 
  • Dominant selection system for use in Cryptococcus neoformans. 
  • Doxycycline and the traveller. 
  • Dynamic and heterogeneous mutations to fluconazole resistance in Cryptococcus neoformans. 
  • Ecology drives a global network of gene exchange connecting the human microbiome. 
  • Emerging and resistant infections. 
  • Essential Resources and Strategies for Antibiotic Stewardship Programs in the Acute Care Setting. 
  • Extended Oral Antibiotics and Infection Prophylaxis after a Primary or Revision Total Knee Arthroplasty. 
  • FK 506-binding protein proline rotamase is a target for the immunosuppressive agent FK 506 in Saccharomyces cerevisiae. 
  • Failure of ketoconazole in cryptococcal meningitis. 
  • Fluconazole and Candida krusei fungemia. 
  • Formation of azole-resistant Candida albicans by mutation of sterol 14-demethylase P450. 
  • General guidelines for clinical bacteriology. Infectious Diseases Society of America and the Food and Drug Administration. 
  • HIV-1 sensitivity to zidovudine and clinical outcome in children. 
  • HIV-1 sensitivity to zidovudine and clinical outcome. 
  • Heterologous URA3MX cassettes for gene replacement in Saccharomyces cerevisiae. 
  • High-dose cefamandole therapy in obstetric and gynecologic infections. 
  • Homologs of the vancomycin resistance D-Ala-D-Ala dipeptidase VanX in Streptomyces toyocaensis, Escherichia coli and Synechocystis: attributes of catalytic efficiency, stereoselectivity and regulation with implications for function. 
  • Hyperkeratotic rim of gram-negative toe web infections. 
  • Immunophilins interact with calcineurin in the absence of exogenous immunosuppressive ligands. 
  • Immunosuppressive and nonimmunosuppressive cyclosporine analogs are toxic to the opportunistic fungal pathogen Cryptococcus neoformans via cyclophilin-dependent inhibition of calcineurin. 
  • Implementation of a Market Entry Reward within the United States. 
  • In vitro resistance to thrombin-induced platelet microbicidal protein among clinical bacteremic isolates of Staphylococcus aureus correlates with an endovascular infectious source. 
  • In vivo and in vitro susceptibility to chloroquine of Plasmodium falciparum in Kinshasa and Mbuji-Mayi, Zaire. 
  • In-vitro activity of dicationic aromatic compounds and fluconazole against Cryptococcus neoformans and Candida spp. 
  • Infections in patients with cystic fibrosis following lung transplantation. 
  • Infectious diseases in pregnancy. 
  • Interpretive criteria and quality control parameters for determining bacterial susceptibility to fosfomycin tromethamine. 
  • Intra- and interpopulation transposition of mobile genetic elements driven by antibiotic selection. 
  • Investigating and Modeling the Regulation of Extracellular Antibiotic Resistance Gene Bioavailability by Naturally Occurring Nanoparticles. 
  • Isolation of Enterobacter aerogenes susceptible to beta-lactam antibiotics despite high level beta-lactamase production. 
  • Lambda transducing phages for the nalA gene of Escherichia coli and conditional lethal nalA mutations. 
  • Mammalian RAFT1 kinase domain provides rapamycin-sensitive TOR function in yeast. 
  • Mathematical model of Klebsiella pneumoniae resistance to amikacin and gentamicin. 
  • Methylfolate Trap Promotes Bacterial Thymineless Death by Sulfa Drugs. 
  • Molecular characterization and multilaboratory evaluation of Enterococcus faecalis ATCC 51299 for quality control of screening tests for vancomycin and high-level aminoglycoside resistance in enterococci. 
  • Moraxella catarrhalis ventriculitis in a child with hydrocephalus and an external ventricular drain. 
  • Multicenter study of in vitro susceptibility of the Bacteroides fragilis group, 1995 to 1996, with comparison of resistance trends from 1990 to 1996. 
  • Multilaboratory evaluation of screening methods for detection of high-level aminoglycoside resistance in enterococci. National Committee for Clinical Laboratory Standards Study Group on Enterococci. 
  • Mutational alteration of the breakage/resealing subunit of bacteriophage T4 DNA topoisomerase confers resistance to antitumor agent m-AMSA. 
  • Mutations in Saccharomyces cerevisiae which confer resistance to several amino acid analogs. 
  • Mutations of the bacteriophage T4 type II DNA topoisomerase that alter sensitivity to antitumor agent 4'-(9-acridinylamino)methanesulfon-m-anisidide and an antibacterial quinolone. 
  • Mutations that perturb cyclophilin A ligand binding pocket confer cyclosporin A resistance in Saccharomyces cerevisiae. 
  • Nanoparticles as vectors for antibiotic resistance: The association of silica nanoparticles with environmentally relevant extracellular antibiotic resistance genes. 
  • Nationwide study of the susceptibility of the Bacteroides fragilis group in the United States. 
  • Neisseria gonorrhoeae strains inhibited by vancomycin in selective media and correlation with auxotype. 
  • Ofloxacin, a new broad-spectrum fluoroquinolone. Results from a Multicenter, National Comparative Activity Surveillance Study. The Ofloxacin Surveillance Group. 
  • Optimization of a Noncanonical Anti-infective: Interrogation of the Target Binding Pocket for a Small-Molecule Inhibitor of Escherichia coli Polysaccharide Capsule Expression. 
  • Parallel evolution of drug resistance in HIV: failure of nonsynonymous/synonymous substitution rate ratio to detect selection. 
  • Persistent Strongyloides stercoralis in a blind loop of the bowel. Successful treatment with mebendazole. 
  • Pharmacist-managed antimicrobial stewardship program for patients discharged from the emergency department. 
  • Point-prevalence study of antimicrobial use in public hospitals in southern Sri Lanka identifies opportunities for improving prescribing practices. 
  • Povidone-iodine to prevent ophthalmia neonatorum. 
  • Protein kinase activity and identification of a toxic effector domain of the target of rapamycin TOR proteins in yeast. 
  • Pseudomonas colonization in cystic fibrosis. A study of 160 patients. 
  • RP 59500, a new streptogramin highly active against recent isolates of North American staphylococci. 
  • Recognition of multiple drugs by a single protein: a trivial solution of an old paradox. 
  • Recovery from disseminated candidiasis in a premature neonate. 
  • Resistance diagnostics as a public health tool to combat antibiotic resistance: A model-based evaluation. 
  • Resistant enterococci: a prospective study of prevalence, incidence, and factors associated with colonization in a university hospital. 
  • Risk factors for ineffective therapy in patients with bloodstream infection. 
  • Role of human immunodeficiency virus (HIV) type 1 envelope in the anti-HIV activity of the betulinic acid derivative IC9564. 
  • Scedosporium species infections and treatments. 
  • Selection of peptides that target the aminoacyl-tRNA site of bacterial 16S ribosomal RNA. 
  • Selective decontamination of digestive tract in intensive care. 
  • Shigellosis in the United States: ten-year review of nationwide surveillance, 1964-1973. 
  • Simultaneous genotyping and species identification using hybridization pattern recognition analysis of generic Mycobacterium DNA arrays. 
  • Spiral gradient endpoint method compared to standard agar dilution for susceptibility testing of anaerobic gram-negative bacilli. 
  • Staphylococcus aureus bacteraemia in a tropical setting: patient outcome and impact of antibiotic resistance. 
  • Staphylococcus aureus sortase A contributes to the Trojan horse mechanism of immune defense evasion with its intrinsic resistance to Cys184 oxidation. 
  • Structural basis of multidrug recognition by BmrR, a transcription activator of a multidrug transporter. 
  • Structural biology of bacterial multidrug resistance gene regulators. 
  • Structural mechanisms of multidrug recognition and regulation by bacterial multidrug transcription factors. 
  • Susceptibilities of anaerobic gram-negative bacilli to thirteen antimicrobials and beta-lactamase inhibitor combinations. 
  • Susceptibility of Aspergillus to 5-fluorocytosine and amphotericin B alone and in combination. 
  • Susceptibility of the Bacteroides fragilis group in the United States in 1981. 
  • Susceptibility of the Bacteroides fragilis group in the United States: analysis by site of isolation. 
  • Susceptibility testing of anaerobic bacteria. 
  • Sutterella wadsworthensis gen. nov., sp. nov., bile-resistant microaerophilic Campylobacter gracilis-like clinical isolates. 
  • TOR mutations confer rapamycin resistance by preventing interaction with FKBP12-rapamycin. 
  • Targets for cell cycle arrest by the immunosuppressant rapamycin in yeast. 
  • Targets of immunophilin-immunosuppressant complexes are distinct highly conserved regions of calcineurin A. 
  • The North American component (the United States and Canada) of an International Comparative MIC trial monitoring ofloxacin resistance. 
  • The Use of Systemic and Topical Fluoroquinolones. 
  • The antimicrobial susceptibility patterns of the Bacteroides fragilis group in the United States, 1987. 
  • The immunosuppressant FK506 and its nonimmunosuppressive analog L-685,818 are toxic to Cryptococcus neoformans by inhibition of a common target protein. 
  • The immunosuppressant FK506 inhibits amino acid import in Saccharomyces cerevisiae. 
  • The impact of antimicrobial resistance on empiric antibiotic selection and antimicrobial use in clinical practice. 
  • The long-term effects of phage concentration on the inhibition of planktonic bacterial cultures. 
  • The next opportunity in anti-malaria drug discovery: the liver stage. 
  • The other function of DNA photolyase: stimulation of excision repair of chemical damage to DNA. 
  • Three new dominant drug resistance cassettes for gene disruption in Saccharomyces cerevisiae. 
  • Time series analysis of rhythmic bacterial resistance development to antibiotics. 
  • Tn5-mediated bleomycin resistance in Escherichia coli requires the expression of host genes. 
  • Transposon Tn5: specific sequence recognition and conservative transposition. 
  • Treatment of vancomycin-resistant enterococci, with a focus on quinupristin-dalfopristin. 
  • Trends in antimicrobial resistance among Bacteroides species and Parabacteroides species in the United States from 2010-2012 with comparison to 2008-2009. 
  • Trends in human immunodeficiency virus (HIV) counseling, testing, and antiretroviral treatment of HIV-infected women and perinatal transmission in North Carolina. 
  • United States geographic bacteria susceptibility patterns. 1996 ASCP Susceptibility Testing Group. American Society of Clinical Pathologists. 
  • United States geographic bacteria susceptibility patterns. 1997 ASCP Susceptibility Testing Group. 
  • Update on resistance of Bacteroides fragilis group and related species with special attention to carbapenems 2006-2009. 
  • Urinary tract pathogens and antimicrobial sensitivity patterns in children in Ibadan, Nigeria. 
  • Use of ototopical antibiotics in treating 3 common ear diseases. 
  • Vancomycin-resistant enterococci: risk related to the use of intravenous vancomycin in a university hospital. 
  • Vertical and horizontal gene transfer tradeoffs direct plasmid fitness. 
  • Vertical transmission of multidrug-resistant human immunodeficiency virus type 1 (HIV-1) and continued evolution of drug resistance in an HIV-1-infected infant. 
  • Zidovudine resistance, syncytium-inducing phenotype, and HIV disease progression in a case-control study. The VA Cooperative Study Group. 
  • [Epidemiology of chemoresistant Plasmodium falciparum]. 
  • [Standardization of antimicrobial procedures using computers]. 
  • crl mutants of Saccharomyces cerevisiae resemble both mutants affecting general control of amino acid biosynthesis and omnipotent translational suppressor mutants. 
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  Keywords of People

  • Pasquale, Dana Kristine, Assistant Professor in Population Health Sciences, Population Health Sciences
  • Stinnett, Sandra Sue, Associate Professor of Biostatistics & Bioinformatics, Biostatistics & Bioinformatics