Pharmaceutical Preparations

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  Subject Areas on Research

  • "Inactive" ingredients in oral medications. 
  • "Take your pill": the role and fantasy of pills in modern medicine. 
  • A Bayesian approach for individual-level drug benefit-risk assessment. 
  • A Computational Study of Nasal Spray Deposition Pattern in Four Ethnic Groups. 
  • A kernel for the Tropical Disease Initiative. 
  • A new era in pharmacotherapy: the need to understand the principles of therapeutic drug monitoring. 
  • A prospective study of the epidemiology of adverse drug reactions in pediatric hematology and oncology patients. 
  • A single acidic residue can guide binding site selection but does not govern QacR cationic-drug affinity. 
  • A structure-based mechanism for drug binding by multidrug transporters. 
  • Access to essential cancer medicines for children: a comparative mixed-methods analysis of availability, price, and health-system determinants in east Africa. 
  • Activation of PKC isoform beta(I) at the blood-brain barrier rapidly decreases P-glycoprotein activity and enhances drug delivery to the brain. 
  • Active-learning strategies in computer-assisted drug discovery. 
  • Actively targeting solid tumours with thermoresponsive drug delivery systems that respond to mild hyperthermia. 
  • Activity of various endogenous compounds and pharmacologic agents at a glucose-oxidizing platinum electrode. 
  • Advances in Pediatric Pharmacology, Therapeutics, and Toxicology. 
  • Adverse drug events in high risk older outpatients. 
  • Adverse events after discontinuing medications in elderly outpatients. 
  • An evaluation of analytic goals for assays of drugs: a College of American Pathologists Therapeutic Drug Monitoring Survey Study. 
  • Anthracenedione antineoplastic agent effects on drug metabolism in vitro and in vivo: relationship between structure and mechanism of inhibition. 
  • Antifibrotic Drug Use in Patients with Idiopathic Pulmonary Fibrosis. Data from the IPF-PRO Registry. 
  • Application of queueing theory to pharmacokinetics. 
  • Appropriate prescribing in elderly people: how well can it be measured and optimised? 
  • Assessing departure from dose linearity under a repeated measures incomplete block design. 
  • Assessment of Clinical Trials Supporting US Food and Drug Administration Approval of Novel Therapeutic Agents, 1995-2017. 
  • Audit of Data Sharing by Pharmaceutical Companies for Anticancer Medicines Approved by the US Food and Drug Administration. 
  • Barriers and potential solutions to international collaboration in neuro-oncology clinical trials: Challenges from the Australian perspective. 
  • Biased signalling: from simple switches to allosteric microprocessors. 
  • Biomarkers as drug development tools: discovery, validation, qualification and use. 
  • Building a drug development database: challenges in reliable data availability. 
  • Cerebral ischemia/stroke and small ubiquitin-like modifier (SUMO) conjugation--a new target for therapeutic intervention? 
  • Challenges and Opportunities to Updating Prescribing Information for Longstanding Oncology Drugs. 
  • Challenges and Potential Improvements to Patient Access to Pharmaceuticals: Examples From Cardiology. 
  • Challenges to integrating pharmacogenetic testing into medication therapy management. 
  • Chemical Denaturation and Protein Precipitation Approach for Discovery and Quantitation of Protein-Drug Interactions. 
  • Classification models for the prediction of clinicians' information needs. 
  • Clinical Pharmacology Studies in Critically Ill Children. 
  • Clinical presentations and outcomes of bile duct loss caused by drugs and herbal and dietary supplements. 
  • Co-opting biology to deliver drugs. 
  • Common non-epigenetic drugs as epigenetic modulators. 
  • Concordance of Drug-resistance Profiles Between Persons With Drug-resistant Tuberculosis and Their Household Contacts: A Systematic Review and Meta-analysis. 
  • Congress, the FDA, and the fair development of new medications for children. 
  • Coping with critical drug shortages: an ethical approach for allocating scarce resources in hospitals. 
  • DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. 
  • Deprescribing Education vs Usual Care for Patients With Cognitive Impairment and Primary Care Clinicians: The OPTIMIZE Pragmatic Cluster Randomized Trial. 
  • Development and validation of XML-based calculations within order sets. 
  • Developmental exposure of zebrafish to vitamin D receptor acting drugs and environmental toxicants disrupts behavioral function. 
  • Developmental pharmacogenomics. 
  • Differentiation of erythroleukemia cells in vitro: properties of chemical inducers. 
  • Disagreements Within the US Food and Drug Administration Regarding Approval of Novel Therapeutic Agents, 2011-2015. 
  • Dosing in neonates: special considerations in physiology and trial design. 
  • Drug properties and host factors contribute to biochemical presentation of drug-induced liver injury: a prediction model from a machine learning approach. 
  • Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome. 
  • Drug rechallenge following drug-induced liver injury. 
  • Drug shortages in the United States: a critical evaluation of root causes and the need for action. 
  • Drugs of Abuse and Heart Failure. 
  • Dry eye medication use and expenditures: data from the medical expenditure panel survey 2001 to 2006. 
  • Early-life epilepsy after acute symptomatic neonatal seizures: A prospective multicenter study. 
  • Effect of bar-code technology on the safety of medication administration. 
  • Effects of an education program for community pharmacists on detecting drug-related problems in elderly patients. 
  • Effects of pharmaceutically active compounds on a mixed microbial community originating from a municipal wastewater treatment plant. 
  • Effects of selected pharmaceutically active compounds on the ammonia oxidizing bacterium Nitrosomonas europaea. 
  • Effects of selected pharmaceutically active compounds on treatment performance in sequencing batch reactors mimicking wastewater treatment plants operations. 
  • Engineered chimeric streptavidin tetramers as novel tools for bioseparations and drug delivery. 
  • Evaluation of multiple mechanism-based toxicity endpoints in primary cultured human hepatocytes for the identification of drugs with clinical hepatotoxicity: Results from 152 marketed drugs with known liver injury profiles. 
  • Evidence-based guidelines for pediatric clinical trials: focus on StaR Child Health. 
  • Fundamentals of Clinical Pharmacology With Application for Pregnant Women. 
  • Gaps in Drug Dosing for Obese Children: A Systematic Review of Commonly Prescribed Emergency Care Medications. 
  • Global health and university patents. 
  • Harms reported by patients in rheumatology drug trials: a systematic review of randomized trials in the cochrane library from an OMERACT working group. 
  • Health care providers' use of a drug information service for pregnancy-related inquiries. 
  • Heavy-atom effect on room temperature phosphorimetry. 
  • Highly-loaded protein nanocarriers prepared by Flash NanoPrecipitation with hydrophobic ion pairing. 
  • How important are drug-drug interactions to the health of older adults? 
  • Identifying genomic and developmental causes of adverse drug reactions in children. 
  • In vitro bioequivalence testing. 
  • Inappropriate medication use among frail elderly inpatients. 
  • Inappropriate prescribing for elderly Americans in a large outpatient population. 
  • Indications, labeling, and outcomes assessment for drugs aimed at improving functional status in older persons: a conversation between aging researchers and FDA regulators. 
  • Individualization of treatments with drugs metabolized by CES1: combining genetics and metabolomics. 
  • Industry perspectives on ICH guidelines. 
  • Inhibition of microsomal oxidative drug metabolism by 1,4-bis (2-[(2-hydroxyethyl)amino]-ethylamino)-9,10-anthracenedione diacetate, a new antineoplastic agent. 
  • Injection drug use practices and HIV infection among people who inject drugs in Kigali, Rwanda: a cross-sectional study. 
  • Innovative clinical trial design for pediatric therapeutics. 
  • Institutional Pediatric Convulsive Status Epilepticus Protocol Decreases Time to First and Second Line Anti-Seizure Medication Administration. 
  • Interplay of gender, age and drug properties on reporting frequency of drug-induced liver injury. 
  • Intranasal Spray Characteristics for Best Drug Delivery in Patients With Chronic Rhinosinusitis. 
  • Introduction: Metals in Medicine. 
  • Is genetic testing for cytochrome P450 polymorphisms ready for implementation? 
  • Is meta-analysis the optimal method to decide the duration of antiplatelet therapy in diabetic patients treated with drug‑eluting stenting? 
  • Isoforms of GPCR proteins combine for diverse signalling. 
  • Machine Learning Uncovers Food- and Excipient-Drug Interactions. 
  • Medication Use in the Neonatal Intensive Care Unit and Changes from 2010 to 2018. 
  • Medication adherence: a challenge for patients with postmenopausal osteoporosis and other chronic illnesses. 
  • Medication taking behaviors in the high- and low-functioning elderly: MacArthur field studies of successful aging. 
  • Metabolomics: a global biochemical approach to drug response and disease. 
  • Methodological and Regulatory Considerations for Updated Guidance on the Pressor Effects of Drugs. 
  • Molecular and Materials Engineering for Delivery of Peptide Drugs to Treat Type 2 Diabetes. 
  • Molecular characterization of CYP2B6 substrates. 
  • Multidimensional Acculturation, Acculturative Stress and Alcohol or Drug Use of Adult Latinx Immigrants. 
  • Neonatal Therapeutics: Considerations for Dosing. 
  • On computational fluid dynamics models for sinonasal drug transport: Relevance of nozzle subtraction and nasal vestibular dilation. 
  • On the assessment of similarity for dissolution profiles of two drug products. 
  • Opportunities for performance improvement in relation to medication administration during pediatric stabilization. 
  • Parenteral administration of oral medications in lung transplant recipients: An underrecognized problem. 
  • Payment Reform, Medication Use, and Costs: Can We Afford to Leave Out Drugs? 
  • Peer-reviewed publication of clinical trials completed for pediatric exclusivity. 
  • Perception of clinical research among patients and healthy volunteers of clinical trials. 
  • Pharmaceuticals as antifoulants: concept and principles. 
  • Pharmacological strategies for the prevention of Alzheimer's disease. 
  • Plasma levels of angiopoietin-2, VEGF-A, and VCAM-1 as markers of bevacizumab-induced hypertension: CALGB 80303 and 90401 (Alliance). 
  • Polymorphisms in genes encoding drug metabolizing enzymes and their influence on the outcome of children with neuroblastoma. 
  • Preconception Evaluation Before In Vitro Fertilization. 
  • Prediction of short-term antidepressant response using probabilistic graphical models with replication across multiple drugs and treatment settings. 
  • Predictive model of multiple emergency department visits among adults: analysis of the data from the National Survey of Drug Use and Health (NSDUH). 
  • Predictors of Willingness to Diffuse PrEP Information within Ego-Centric Networks of Women Who Inject Drugs. 
  • Prescriptions for justice: using social accounts to legitimate the exercise of professional control. 
  • Priorities for the Priority Review Voucher. 
  • Probability lower bounds for USP/NF tests. 
  • Quantifying the utility of taking pills for preventing adverse health outcomes: a cross-sectional survey. 
  • Quantitative proteomics approach for identifying protein-drug interactions in complex mixtures using protein stability measurements. 
  • Racial and Ethnic Diversity in Studies Funded Under the Best Pharmaceuticals for Children Act. 
  • Recombinant Synthesis of Hybrid Lipid-Peptide Polymer Fusions that Self-Assemble and Encapsulate Hydrophobic Drugs. 
  • Safety and feasibility of adjunctive antiplatelet therapy with intravenous elinogrel, a direct-acting and reversible P2Y12 ADP-receptor antagonist, before primary percutaneous intervention in patients with ST-elevation myocardial infarction: the Early Rapid ReversAl of platelet thromboSis with intravenous Elinogrel before PCI to optimize reperfusion in acute Myocardial Infarction (ERASE MI) pilot trial. 
  • Safety and transparency of pediatric drug trials. 
  • Safety, dosing, and pharmaceutical quality for studies that evaluate medicinal products (including biological products) in neonates. 
  • Screening of 16 common therapeutic drugs. Possible association with the Ah locus. 
  • Selection of Informative Examples in Chemogenomic Datasets. 
  • Self-assembly of thermally responsive nanoparticles of a genetically encoded peptide polymer by drug conjugation. 
  • Sex, drugs, and race: how behaviors differentially contribute to the sexually transmitted infection risk network structure. 
  • Sex-related differences in clinical drug response: Implications for women's health 
  • Should the patent system for new medicines be abolished? 
  • Similarity of drug names. 
  • Some disease-modifying osteoarthritis drugs make small improvements in knee and hip osteoarthritis. 
  • Sources of variability: a College of American Pathologists Therapeutic Drug Monitoring study. 
  • Specialty knowledge and competency standards for pharmacotherapy for pediatric obsessive-compulsive disorder. 
  • Stability analysis for drugs with multiple active ingredients. 
  • Statistical methods for bridging studies. 
  • Statistical methods for exploring spontaneous adverse event reporting databases for drug-host factor interactions. 
  • Steady state variables in the guarded receptor hypothesis. 
  • Structural model of human PORCN illuminates disease-associated variants and drug-binding sites. 
  • Synaptic plasticity in drug reward circuitry. 
  • Systematic review on irrational use of medicines in China and Vietnam. 
  • The Impact of Pregnancy on Antihypertensive Drug Metabolism and Pharmacokinetics: Current Status and Future Directions. 
  • The NCI Biomedical Imaging Program: five-year progress report. 
  • The Untapped Potential of Pharmacy Leaflets for Informing Patients About Drug Benefits and Risks. 
  • The effect of variance function estimation on nonlinear calibration inference in immunoassay data. 
  • The genomic epidemiology of multi-drug resistant invasive non-typhoidal Salmonella in selected sub-Saharan African countries. 
  • The influence of health literacy level on an educational intervention to improve glaucoma medication adherence. 
  • The potential of a placebo/nocebo effect in pharmacogenetics. 
  • Thermo-responsive systems for controlled drug delivery 
  • Transdermal drug delivery enhanced and controlled by erbium:YAG laser: a comparative study of lipophilic and hydrophilic drugs. 
  • US changes trade policy on essential medicines. 
  • Underuse of indicated medications among physically frail older US veterans at the time of hospital discharge: results of a cross-sectional analysis of data from the Geriatric Evaluation and Management Drug Study. 
  • Unpredictable drug shortages: an ethical framework for short-term rationing in hospitals. 
  • Using a computerized provider order entry system to meet the unique prescribing needs of children: description of an advanced dosing model. 
  • Using pharmacogenetics to improve drug safety and efficacy. 
  • What types of inappropriate prescribing predict adverse drug reactions in older adults? 
  • Why not real economics? 
  • Wide range of perioperative drugs and doses used in inguinal hernia repairs for premature infants. 
  • Xenobiotic metabolism and transport in Caenorhabditis elegans . 
  • t⁴ workshop report. Nanotoxicology: "the end of the beginning" - signs on the roadmap to a strategy for assuring the safe application and use of nanomaterials. 
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  Keywords of People

  • Cohen-Wolkowiez, Michael, Kiser-Arena Distinguished Professor, Pediatrics, Infectious Diseases
  • Muir, Kelly Walton, Associate Professor of Ophthalmology, Ophthalmology, Glaucoma
  • Stinnett, Sandra Sue, Associate Professor of Biostatistics & Bioinformatics, Biostatistics & Bioinformatics
  • Sullivan, Daniel Carl, Professor Emeritus of Radiology, Radiology