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Subject Areas on Research
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Adult exposure to insecticides causes persistent behavioral and neurochemical alterations in zebrafish.
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Adverse benzo[a]pyrene effects on neurodifferentiation are altered by other neurotoxicant coexposures: interactions with dexamethasone, chlorpyrifos, or nicotine in PC12 cells.
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Adverse outcome pathways during early fish development: a conceptual framework for identification of chemical screening and prioritization strategies.
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Age- and gender-related differences in sensitivity to chlorpyrifos in the rat reflect developmental profiles of esterase activities.
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Age- and gender-related differences in the time course of behavioral and biochemical effects produced by oral chlorpyrifos in rats.
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Alpha7 nicotinic acetylcholine receptors targeted by cholinergic developmental neurotoxicants: nicotine and chlorpyrifos.
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Alterations in central nervous system serotonergic and dopaminergic synaptic activity in adulthood after prenatal or neonatal chlorpyrifos exposure.
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Alterations in serotonin transporter expression in brain regions of rats exposed neonatally to chlorpyrifos.
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Ameliorating the developmental neurotoxicity of chlorpyrifos: a mechanisms-based approach in PC12 cells.
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Amyloid precursor protein 96-110 and beta-amyloid 1-42 elicit developmental anomalies in sea urchin embryos and larvae that are alleviated by neurotransmitter analogs for acetylcholine, serotonin and cannabinoids.
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An invertebrate model of the developmental neurotoxicity of insecticides: effects of chlorpyrifos and dieldrin in sea urchin embryos and larvae.
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Behavioral alterations in adolescent and adult rats caused by a brief subtoxic exposure to chlorpyrifos during neurulation.
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Behavioral and neurochemical effects of acute chlorpyrifos in rats: tolerance to prolonged inhibition of cholinesterase.
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Benzo[a]pyrene impairs neurodifferentiation in PC12 cells.
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Brain anomalies in children exposed prenatally to a common organophosphate pesticide.
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Cellular mechanisms for developmental toxicity of chlorpyrifos: targeting the adenylyl cyclase signaling cascade.
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Chlorpyrifos accumulation patterns for child-accessible surfaces and objects and urinary metabolite excretion by children for 2 weeks after crack-and-crevice application.
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Chlorpyrifos affects phenotypic outcomes in a model of mammalian neurodevelopment: critical stages targeting differentiation in PC12 cells.
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Chlorpyrifos developmental neurotoxicity: interaction with glucocorticoids in PC12 cells.
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Chlorpyrifos elicits mitotic abnormalities and apoptosis in neuroepithelium of cultured rat embryos.
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Chlorpyrifos exposure during a critical neonatal period elicits gender-selective deficits in the development of coordination skills and locomotor activity.
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Chlorpyrifos exposure during neurulation: cholinergic synaptic dysfunction and cellular alterations in brain regions at adolescence and adulthood.
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Chlorpyrifos exposure of developing zebrafish: effects on survival and long-term effects on response latency and spatial discrimination.
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Chlorpyrifos interferes with cell development in rat brain regions.
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Chlorpyrifos releases norepinephrine from adult and neonatal rat brain synaptosomes.
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Chlorpyrifos targets developing glia: effects on glial fibrillary acidic protein.
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Cholinergic synaptic signaling mechanisms underlying behavioral teratogenicity: effects of nicotine, chlorpyrifos, and heroin converge on protein kinase C translocation in the intermedial part of the hyperstriatum ventrale and on imprinting behavior in an avian model.
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Comparative Assessment of Pesticide Exposures in Domestic Dogs and Their Owners Using Silicone Passive Samplers and Biomonitoring.
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Comparison of the in vitro sensitivity of rat acetylcholinesterase to chlorpyrifos-oxon: what do tissue IC50 values represent?
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Comparison of the role of esterases in the differential age-related sensitivity to chlorpyrifos and methamidophos.
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Contamination of rural surface and ground water by endosulfan in farming areas of the Western Cape, South Africa.
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Critical duration of exposure for developmental chlorpyrifos-induced neurobehavioral toxicity.
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Critical periods for chlorpyrifos-induced developmental neurotoxicity: alterations in adenylyl cyclase signaling in adult rat brain regions after gestational or neonatal exposure.
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Critical periods for the role of oxidative stress in the developmental neurotoxicity of chlorpyrifos and terbutaline, alone or in combination.
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Developmental chlorpyrifos effects on hatchling zebrafish swimming behavior.
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Developmental cholinotoxicants: nicotine and chlorpyrifos.
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Developmental effects of chlorpyrifos extend beyond neurotoxicity: critical periods for immediate and delayed-onset effects on cardiac and hepatic cell signaling.
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Developmental exposure of rats to chlorpyrifos elicits sex-selective hyperlipidemia and hyperinsulinemia in adulthood.
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Developmental exposure of rats to chlorpyrifos leads to behavioral alterations in adulthood, involving serotonergic mechanisms and resembling animal models of depression.
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Developmental exposure to chlorpyrifos elicits sex-selective alterations of serotonergic synaptic function in adulthood: critical periods and regional selectivity for effects on the serotonin transporter, receptor subtypes, and cell signaling.
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Developmental exposure to organophosphates triggers transcriptional changes in genes associated with Parkinson's disease in vitro and in vivo.
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Developmental exposure to terbutaline alters cell signaling in mature rat brain regions and augments the effects of subsequent neonatal exposure to the organophosphorus insecticide chlorpyrifos.
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Developmental exposure to terbutaline and chlorpyrifos, separately or sequentially, elicits presynaptic serotonergic hyperactivity in juvenile and adolescent rats.
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Developmental exposure to terbutaline and chlorpyrifos: pharmacotherapy of preterm labor and an environmental neurotoxicant converge on serotonergic systems in neonatal rat brain regions.
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Developmental neurotoxic effects of chlorpyrifos on acetylcholine and serotonin pathways in an avian model.
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Developmental neurotoxicants target neurodifferentiation into the serotonin phenotype: Chlorpyrifos, diazinon, dieldrin and divalent nickel.
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Developmental neurotoxicity elicited by gestational exposure to chlorpyrifos: when is adenylyl cyclase a target?
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Developmental neurotoxicity elicited by prenatal or postnatal chlorpyrifos exposure: effects on neurospecific proteins indicate changing vulnerabilities.
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Developmental neurotoxicity of chlorpyrifos in vivo and in vitro: effects on nuclear transcription factors involved in cell replication and differentiation.
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Developmental neurotoxicity of chlorpyrifos modeled in vitro: comparative effects of metabolites and other cholinesterase inhibitors on DNA synthesis in PC12 and C6 cells.
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Developmental neurotoxicity of chlorpyrifos: cellular mechanisms.
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Developmental neurotoxicity of chlorpyrifos: delayed targeting of DNA synthesis after repeated administration.
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Developmental neurotoxicity of chlorpyrifos: what is the vulnerable period?
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Developmental neurotoxicity of organophosphates targets cell cycle and apoptosis, revealed by transcriptional profiles in vivo and in vitro.
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Developmental neurotoxicity targeting hepatic and cardiac sympathetic innervation: effects of organophosphates are distinct from those of glucocorticoids.
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Differential acetylcholinesterase inhibition of chlorpyrifos, diazinon and parathion in larval zebrafish.
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Disparate developmental neurotoxicants converge on the cyclic AMP signaling cascade, revealed by transcriptional profiles in vitro and in vivo.
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Diverse neurotoxicants converge on gene expression for neuropeptides and their receptors in an in vitro model of neurodifferentiation: effects of chlorpyrifos, diazinon, dieldrin and divalent nickel in PC12 cells.
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Does pharmacotherapy for preterm labor sensitize the developing brain to environmental neurotoxicants? Cellular and synaptic effects of sequential exposure to terbutaline and chlorpyrifos in neonatal rats.
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Does the developmental neurotoxicity of chlorpyrifos involve glial targets? Macromolecule synthesis, adenylyl cyclase signaling, nuclear transcription factors, and formation of reactive oxygen in C6 glioma cells.
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Does thyroid disruption contribute to the developmental neurotoxicity of chlorpyrifos?
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Early biochemical detection of delayed neurotoxicity resulting from developmental exposure to chloropyrifos.
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Esterase metabolism of cholinesterase inhibitors using rat liver in vitro.
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Exposure to organophosphates reduces the expression of neurotrophic factors in neonatal rat brain regions: similarities and differences in the effects of chlorpyrifos and diazinon on the fibroblast growth factor superfamily.
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Factors in standardizing automated cholinesterase assays.
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Fetal chlorpyrifos exposure: adverse effects on brain cell development and cholinergic biomarkers emerge postnatally and continue into adolescence and adulthood.
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Fetal nicotinic overload, blunted sympathetic responsivity, and obesity.
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Gestational exposure to chlorpyrifos: apparent protection of the fetus?
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Gestational exposure to chlorpyrifos: comparative distribution of trichloropyridinol in the fetus and dam.
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Gestational exposure to chlorpyrifos: dose response profiles for cholinesterase and carboxylesterase activity.
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Imbalances emerge in cardiac autonomic cell signaling after neonatal exposure to terbutaline or chlorpyrifos, alone or in combination.
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In utero exposure to nicotine and chlorpyrifos alone, and in combination produces persistent sensorimotor deficits and Purkinje neuron loss in the cerebellum of adult offspring rats.
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Is fipronil safer than chlorpyrifos? Comparative developmental neurotoxicity modeled in PC12 cells.
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Is oxidative stress involved in the developmental neurotoxicity of chlorpyrifos?
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Maturational differences in chlorpyrifos-oxonase activity may contribute to age-related sensitivity to chlorpyrifos.
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Modeling the developmental neurotoxicity of chlorpyrifos in vitro: macromolecule synthesis in PC12 cells.
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Modeling the developmental neurotoxicity of chlorpyrifos in vitro: macromolecule synthesis in PC12 cells.
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Morphologic effects of subtoxic neonatal chlorpyrifos exposure in developing rat brain: regionally selective alterations in neurons and glia.
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Neonatal chlorpyrifos administration elicits deficits in immune function in adulthood: a neural effect?
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Neonatal chlorpyrifos exposure alters synaptic development and neuronal activity in cholinergic and catecholaminergic pathways.
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Neonatal chlorpyrifos exposure targets multiple proteins governing the hepatic adenylyl cyclase signaling cascade: implications for neurotoxicity.
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Neurobehavioral anomalies in zebrafish after sequential exposures to DDT and chlorpyrifos in adulthood: Do multiple exposures interact?
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Neurobehavioral effects of chronic dietary and repeated high-level spike exposure to chlorpyrifos in rats.
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Neurochemical effects of chronic dietary and repeated high-level acute exposure to chlorpyrifos in rats.
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Nicotine is a developmental neurotoxicant and neuroprotectant: stage-selective inhibition of DNA synthesis coincident with shielding from effects of chlorpyrifos.
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Nonenzymatic functions of acetylcholinesterase splice variants in the developmental neurotoxicity of organophosphates: chlorpyrifos, chlorpyrifos oxon, and diazinon.
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Organophosphate exposure during a critical developmental stage reprograms adenylyl cyclase signaling in PC12 cells.
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Oxidative and excitatory mechanisms of developmental neurotoxicity: transcriptional profiles for chlorpyrifos, diazinon, dieldrin, and divalent nickel in PC12 cells.
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Oxidative mechanisms contributing to the developmental neurotoxicity of nicotine and chlorpyrifos.
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Oxidative stress from diverse developmental neurotoxicants: antioxidants protect against lipid peroxidation without preventing cell loss.
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Perinatal diazinon exposure compromises the development of acetylcholine and serotonin systems.
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Perinatal exposure to environmental tobacco smoke upregulates nicotinic cholinergic receptors in monkey brain.
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Persistent behavioral consequences of neonatal chlorpyrifos exposure in rats.
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Persistent cholinergic presynaptic deficits after neonatal chlorpyrifos exposure.
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Prenatal chlorpyrifos exposure elicits presynaptic serotonergic and dopaminergic hyperactivity at adolescence: critical periods for regional and sex-selective effects.
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Prenatal chlorpyrifos exposure in rats causes persistent behavioral alterations.
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Prenatal dexamethasone augments the neurobehavioral teratology of chlorpyrifos: significance for maternal stress and preterm labor.
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Prenatal dexamethasone augments the sex-selective developmental neurotoxicity of chlorpyrifos: implications for vulnerability after pharmacotherapy for preterm labor.
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Prenatal dexamethasone, as used in preterm labor, worsens the impact of postnatal chlorpyrifos exposure on serotonergic pathways.
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Prenatal drug exposures sensitize noradrenergic circuits to subsequent disruption by chlorpyrifos.
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Prenatal nicotine alters the developmental neurotoxicity of postnatal chlorpyrifos directed toward cholinergic systems: better, worse, or just "different?".
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Prenatal nicotine changes the response to postnatal chlorpyrifos: Interactions targeting serotonergic synaptic function and cognition.
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Protein kinase C is a target for diverse developmental neurotoxicants: transcriptional responses to chlorpyrifos, diazinon, dieldrin and divalent nickel in PC12 cells.
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Quantitative morphological assessment reveals neuronal and glial deficits in hippocampus after a brief subtoxic exposure to chlorpyrifos in neonatal rats.
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Re: age-related brain cholinesterase inhibition kinetics following in vitro incubation with chlorpyrifos-oxon and diazinon-oxon.
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Response to the letter of Hanley et al. ([1999] Teratology 59:323-324), concerning the article by Roy et al. ([1998] Teratology 58:62-68).
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Reversal of chlorpyrifos neurobehavioral teratogenicity in mice by allographic transplantation of adult subventricular zone-derived neural stem cells.
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Reversal of chlorpyrifos neurobehavioral teratogenicity in mice by nicotine administration and neural stem cell transplantation.
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Sensorimotor deficits and increased brain nicotinic acetylcholine receptors following exposure to chlorpyrifos and/or nicotine in rats.
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Serotonergic systems targeted by developmental exposure to chlorpyrifos: effects during different critical periods.
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Silver impairs neurodevelopment: studies in PC12 cells.
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Slow accumulation of acetylcholinesterase in rat brain during enzyme inhibition by repeated dosing with chlorpyrifos.
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Studies on the correlation between blood cholinesterase inhibition and 'target tissue' inhibition in pesticide-treated rats.
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Synergism of chlorpyrifos against the German cockroach, Blattella germanica.
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Targeting of neurotrophic factors, their receptors, and signaling pathways in the developmental neurotoxicity of organophosphates in vivo and in vitro.
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The alterations in CNS serotonergic mechanisms caused by neonatal chlorpyrifos exposure are permanent.
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The relationship of oral chlorpyrifos effects on behavior, cholinesterase inhibition, and muscarinic receptor density in rat.
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The sea urchin embryo, an invertebrate model for mammalian developmental neurotoxicity, reveals multiple neurotransmitter mechanisms for effects of chlorpyrifos: therapeutic interventions and a comparison with the monoamine depleter, reserpine.
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Tissue-specific effects of chlorpyrifos on carboxylesterase and cholinesterase activity in adult rats: an in vitro and in vivo comparison.
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Transcriptional biomarkers distinguish between vulnerable periods for developmental neurotoxicity of chlorpyrifos: Implications for toxicogenomics.
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Transcriptional profiles for glutamate transporters reveal differences between organophosphates but similarities with unrelated neurotoxicants.
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Transcriptional profiles reveal similarities and differences in the effects of developmental neurotoxicants on differentiation into neurotransmitter phenotypes in PC12 cells.
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Ultraviolet photolysis of chlorpyrifos: developmental neurotoxicity modeled in PC12 cells.
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Validation of the use of 6,6'-dithiodinicotinic acid as a chromogen in the Ellman method for cholinesterase determinations.
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Zebrafish as a neurotoxicological model.
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Zebrafish provide a sensitive model of persisting neurobehavioral effects of developmental chlorpyrifos exposure: comparison with nicotine and pilocarpine effects and relationship to dopamine deficits.
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[Cholinergic regulation of the sea urchin embryonic and larval development].
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Keywords of People