Edetic Acid

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  Subject Areas on Research

  • "Off-the-Shelf" K2-EDTA for Calcific Band Keratopathy. 
  • 68Ga-PSMA PET/CT and PET/MRI in high-risk prostate cancer patients. 
  • A New Panel-Estimated GFR, Including β2-Microglobulin and β-Trace Protein and Not Including Race, Developed in a Diverse Population. 
  • A kinetic study of embryonic cell adhesion. 
  • A rapid fluorescence assay for FtsZ assembly indicates cooperative assembly with a dimer nucleus. 
  • Additivity and the physical basis of multivalency effects: a thermodynamic investigation of the calcium EDTA interaction. 
  • Benchmarking ultra-high molecular weight DNA preservation methods for long-read and long-range sequencing. 
  • CD45 mAb induces cell adhesion in peripheral blood mononuclear cells via lymphocyte function-associated antigen-1 (LFA-1) and intercellular cell adhesion molecule 1 (ICAM-1). 
  • Cathepsin B1. A lysosomal enzyme that degrades native collagen. 
  • Characterization of Mn(III) complexes of linear and cyclic desferrioxamines as mimics of superoxide dismutase activity. 
  • Characterization of a Ca2+-calmodulin-stimulated cyclic GMP phosphodiesterase from bovine brain. 
  • Characterization of a spectrophotometric assay for cAMP phosphodiesterase. 
  • Chelation therapy and cardiovascular outcomes--in reply. 
  • Comparison of blood collected in acid-citrate-dextrose and EDTA for use in human immunodeficiency virus peripheral blood mononuclear cell cultures. 
  • Conditions influencing the interaction of asialo von Willebrand factor with human platelets--the effects of external ionized calcium concentration and the role of arachidonate pathway. 
  • Cooperative interaction of divalent metal ions, substrate, and tissue factor with factor VIIa. 
  • Critical role of chromium (Cr)-DNA interactions in the formation of Cr-induced polymerase arresting lesions. 
  • Cupric ion/ascorbate/hydrogen peroxide-induced DNA damage: DNA-bound copper ion primarily induces base modifications. 
  • Degradation of collagen by a human granulocyte collagenolytic system. 
  • Demonstration and characterization of specific binding sites for factor VIII/von Willebrand factor on human platelets. 
  • Design of the Trial to Assess Chelation Therapy (TACT). 
  • Differential Outcomes With Edetate Disodium-Based Treatment Among Stable Post Anterior vs. Non-Anterior Myocardial Infarction Patients. 
  • Differential adherence of hydrophobic and hydrophilic Candida albicans yeast cells to mouse tissues. 
  • Differential sensitivity of chromium-mediated DNA interstrand crosslinks and DNA-protein crosslinks to disruption by alkali and EDTA. 
  • EDTA chelation therapy alone and in combination with oral high-dose multivitamins and minerals for coronary disease: The factorial group results of the Trial to Assess Chelation Therapy. 
  • Effect of C4 depletion on the utilization of the terminal components of guinea-pig complement by endotoxin. 
  • Effect of disodium EDTA chelation regimen on cardiovascular events in patients with previous myocardial infarction: the TACT randomized trial. 
  • Effect of hydrostatic pressure gradients and Na2EDTA on permeability of human Schlemm's canal cell monolayers. 
  • Effect of temperature, pH, and metals on the stability and activity of phenylalanine hydroxylase from Chromobacterium violaceum. 
  • Enzymatic characterization of a mutant of Escherichia coli with an altered DNA ligase. 
  • Evidence for a novel insulin-like growth factor (IGF)-dependent protease regulating IGF-binding protein-4 in dermal fibroblasts. 
  • Facilitation of granule cell epileptiform activity by mossy fiber-released zinc in the pilocarpine model of temporal lobe epilepsy. 
  • Factors that influence siderophoremediated iron bioavailability: catalysis of interligand iron (III) transfer from ferrioxamine B to EDTA by hydroxamic acids. 
  • Free sphingosine formation from endogenous substrates by a liver plasma membrane system with a divalent cation dependence and a neutral pH optimum. 
  • FtsZ condensates: an in vitro electron microscopy study. 
  • Functional differences in the multiple hemocyanins of the horseshoe crab, Limulus polyphemus L. 
  • Generation of chemotactic activity by immune complexes carrying clustered or nonclustered C42 sites. 
  • Heavy Metals, Cardiovascular Disease, and the Unexpected Benefits of Chelation Therapy. 
  • Hepatitis delta virus ribozymes fold to generate a solvent-inaccessible core with essential nucleotides near the cleavage site phosphate. 
  • High level expression of mammalian protein farnesyltransferase in a baculovirus system. The purified protein contains zinc. 
  • Influence of metal ions on substrate binding and catalytic activity of mammalian protein geranylgeranyltransferase type-I. 
  • Influence of sample collection and storage on the detection of platelet factor 4-heparin antibodies. 
  • Irreversible stimulation of adenylate cyclase activity of fat cell membranes of phosphoramidate and phosphonate analogs of GTP. 
  • Kinetics of iron release from ferric binding protein (FbpA): mechanistic implications in bacterial periplasm-to-cytosol Fe3+ transport. 
  • Lipid modification gives rise to two distinct Haloferax volcanii S-layer glycoprotein populations. 
  • Liver lesions: manganese-enhanced MR and dual-phase helical CT for preoperative detection and characterization comparison with receiver operating characteristic analysis. 
  • Magnetic resonance imaging after arterial portography with manganese dipyridoxal diphosphate. 
  • Mammalian protein geranylgeranyltransferase. Subunit composition and metal requirements. 
  • Manganese dipyridoxyl diphosphate. Effect of dose, time, and pulse sequence on hepatic enhancement in rats. 
  • Mapping staphylococcal nuclease conformation using an EDTA-Fe derivative attached to genetically engineered cysteine residues. 
  • NMR studies of combined lanthanide shift and relaxation agents for differential characterization of 23Na in a two-compartment model system. 
  • Neutral proteinase of rabbit skin: an enzyme capable of degrading skin protein and inducing an inflammatory response. 
  • Nuclear magnetic resonance study of ligand binding to Mn-aspartate transcarbamylase. 
  • Optimized solubilization of TRIzol-precipitated protein permits Western blotting analysis to maximize data available from brain tissue. 
  • Possible differential benefits of edetate disodium in post-myocardial infarction patients with diabetes treated with different hypoglycemic strategies in the Trial to Assess Chelation Therapy (TACT). 
  • Protease activity of normal and PHA stimulated human lymphocytes. 
  • Quality-of-life outcomes with a disodium EDTA chelation regimen for coronary disease: results from the trial to assess chelation therapy randomized trial. 
  • Regulation of leukocyte migration by activation of the leukocyte adhesion molecule-1 (LAM-1) selectin. 
  • Release of [3H]norepinephrine from synaptic vesicles isolated from rat brain after the intracisternal administration of [3H]norepinephrine: influence of nucleotides, ions and drugs, and destabilization of transmitter storage caused by acute or chronic lithium administration. 
  • Responses to propofol in the pulmonary vascular bed of the rat. 
  • Role of granulocyte collagenase in collagen degradation. 
  • Safety and efficacy of mangafodipir trisodium (MnDPDP) injection for hepatic MRI in adults: results of the U.S. multicenter phase III clinical trials (safety). 
  • Section Editor's Notebook: Prostate Cancer Theranosis in Clinical Practice and in Clinical Trials-68Ga-Prostate-Specific Member Antigen (PSMA)-11 PET/CT and 177Lu-PSMA-617 Therapy. 
  • Sedimentation and volume analysis of human bone marrow. 
  • Stimulation of cell-free polypeptide synthesis by a protein fraction extracted from chick oviduct polyribosomes. 
  • Structure of human platelet membrane glycoproteins IIb and IIIa as determined by electron microscopy. 
  • Surface-bound iron: a metal ion buffer in the marine brown alga Ectocarpus siliculosus? 
  • The chemotactic attraction of human fibroblasts to a lymphocyte-derived factor. 
  • The effect of EDTA-based chelation on patients with diabetes and peripheral artery disease in the Trial to Assess Chelation Therapy (TACT). 
  • The effect of an EDTA-based chelation regimen on patients with diabetes mellitus and prior myocardial infarction in the Trial to Assess Chelation Therapy (TACT). 
  • The effect of protein synthesis inhibition on the entry of messenger RNA into the cytoplasm of sea urchin embryos. 
  • The kinetics of dimethylhydroxypyridinone interactions with iron(iii) and the catalysis of iron(iii) ligand exchange reactions: implications for bacterial iron transport and combination chelation therapies. 
  • The rapid and large scale separation of peritoneal macrophages. 
  • The response of circulating parameters of bone mineral metabolism to ethanol- and EDTA-induced hypocalcemia in the rat. 
  • The straight and curved conformation of FtsZ protofilaments-evidence for rapid exchange of GTP into the curved protofilament. 
  • The syndrome of hyperostosis and hyperphosphatemia. 
  • The third component of complement: covalent attachment of a radioactive sugar to the labile binding site of C3 via the alternative pathway. 
  • The trial to assess chelation therapy 2 (TACT2): Rationale and design. 
  • The unusual UBZ domain of Saccharomyces cerevisiae polymerase η. 
  • The use of chemical treatments for improved comminution of artificial stones. 
  • The use of gradient flow compensation to separate diffusion and microcirculatory flow in MRI. 
  • The zinc finger cluster domain of RanBP2 is a specific docking site for the nuclear export factor, exportin-1. 
  • Transition metal-chelate complexes as relaxation modifiers in nuclear magnetic resonance. 
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  Keywords of People

  • Bennett, Vann, George Barth Geller Distinguished Professor of Molecular Biology, Duke Cancer Institute
  • Erickson, Harold Paul, James B. Duke Distinguished Professor Emeritus, Cell Biology
  • Preminger, Glenn Michael, James F. Glenn, M.D. Distinguished Professor of Urology, Surgery, Urology