Elastin
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Subject Areas on Research
- A depot-forming glucagon-like peptide-1 fusion protein reduces blood glucose for five days with a single injection.
- A feasibility study of a thermally sensitive elastin-like polypeptide for submucosal injection application in endoscopic resection in 3 animal models.
- A genetically engineered thermally responsive sustained release curcumin depot to treat neuroinflammation.
- A highly parallel method for synthesizing DNA repeats enables the discovery of 'smart' protein polymers.
- A thermally responsive biopolymer for intra-articular drug delivery.
- A unified model for de novo design of elastin-like polypeptides with tunable inverse transition temperatures.
- Allosteric actuation of inverse phase transition of a stimulus-responsive fusion polypeptide by ligand binding.
- Alveolar septal structure in different species.
- An infrared spectroscopic study of the conformational transition of elastin-like polypeptides.
- An injectable and in situ-gelling biopolymer for sustained drug release following perineural administration.
- Anatomy and physiology of cervical ripening.
- Applications of elastin-like polypeptides in drug delivery.
- Applications of elastin-like polypeptides in tissue engineering.
- Aqueous two-phase system formation kinetics for elastin-like polypeptides of varying chain length.
- Bio-inspired synthesis of hybrid silica nanoparticles templated from elastin-like polypeptide micelles.
- Biomaterials based on new polyurethane and hydrolyzed collagen, k-elastin, hyaluronic acid and chondroitin sulfate.
- Brachytherapy using injectable seeds that are self-assembled from genetically encoded polypeptides in situ.
- Calcium binding peptide motifs from calmodulin confer divalent ion selectivity to elastin-like polypeptides.
- Capture and release of proteins on the nanoscale by stimuli-responsive elastin-like polypeptide "switches".
- Cellular and connective tissue changes in alveolar septal walls in emphysema.
- Chain stiffness of elastin-like polypeptides.
- Changes in dermal histomorphology following surgical weight loss versus diet-induced weight loss in the morbidly obese patient.
- Characterization of a genetically engineered elastin-like polypeptide for cartilaginous tissue repair.
- Cholesterol-fed and casein-fed rabbit models of atherosclerosis. Part 2: Differing morphological severity of atherogenesis despite matched plasma cholesterol levels.
- Chondrocytic differentiation of human adipose-derived adult stem cells in elastin-like polypeptide.
- Comparison of aortic intima and inner media in young adult versus aging rats. Stereology in a polarized system.
- Conclusive evidence for the presence of elastin in human and monkey cervix.
- Convergence of Artificial Protein Polymers and Intrinsically Disordered Proteins.
- Decreased elastic fibers and desmosine content in incompetent cervix.
- Development and characterization of a fusion protein between thermally responsive elastin-like polypeptide and interleukin-1 receptor antagonist: sustained release of a local antiinflammatory therapeutic.
- Drug delivery to solid tumors by elastin-like polypeptides.
- Drug targeting using thermally responsive polymers and local hyperthermia.
- Early metabolite levels predict long-term matrix accumulation for chondrocytes in elastin-like polypeptide biopolymer scaffolds.
- Effect of detergents on the thermal behavior of elastin-like polypeptides.
- Effects of Hofmeister anions on the phase transition temperature of elastin-like polypeptides.
- Elastin-like polypeptides as a purification tag for recombinant proteins.
- Elastin-like polypeptides as models of intrinsically disordered proteins.
- Elastin-like polypeptides: biomedical applications of tunable biopolymers.
- Enhanced uptake of a thermally responsive polypeptide by tumor cells in response to its hyperthermia-mediated phase transition.
- Evaluation of an elastin-like polypeptide-doxorubicin conjugate for cancer therapy.
- Expression and purification of recombinant proteins from Escherichia coli: Comparison of an elastin-like polypeptide fusion with an oligohistidine fusion.
- Extracellular lipid deposition in atherosclerosis.
- Extracellular matrix remodeling after balloon angioplasty injury in a rabbit model of restenosis.
- Fabrication of a reversible protein array directly from cell lysate using a stimuli-responsive polypeptide.
- Fabrication of elastin-like polypeptide nanoparticles for drug delivery by electrospraying.
- Force-induced prolyl cis-trans isomerization in elastin-like polypeptides.
- Function and biomechanics of tendons.
- Functional Modification of Silica through Enhanced Adsorption of Elastin-Like Polypeptide Block Copolymers.
- Fusion order controls expression level and activity of elastin-like polypeptide fusion proteins.
- Fusions of elastin-like polypeptides to pharmaceutical proteins.
- Genetically encoded lipid-polypeptide hybrid biomaterials that exhibit temperature-triggered hierarchical self-assembly.
- Genetically encoded synthesis of protein-based polymers with precisely specified molecular weight and sequence by recursive directional ligation: examples from the elastin-like polypeptide system.
- Hydration layer coupling and cooperativity in phase behavior of stimulus responsive peptide polymers.
- Hydrogen bonding of beta-turn structure is stabilized in D(2)O.
- Improved non-chromatographic purification of a recombinant protein by cationic elastin-like polypeptides.
- In situ cross-linking of elastin-like polypeptide block copolymers for tissue repair.
- In situ crosslinking elastin-like polypeptide gels for application to articular cartilage repair in a goat osteochondral defect model.
- In vitro chondrogenesis of mesenchymal stem cells in recombinant silk-elastinlike hydrogels.
- In vivo tumor targeting by a NGR-decorated micelle of a recombinant diblock copolypeptide.
- Increased matrix metalloproteinase-9 with elastolysis in nocturnal asthma.
- Inhaled NO improves early pulmonary function and modifies lung growth and elastin deposition in a baboon model of neonatal chronic lung disease.
- Injectable biomaterials and vertebral endplate treatment for repair and regeneration of the intervertebral disc.
- Injectable intratumoral depot of thermally responsive polypeptide-radionuclide conjugates delays tumor progression in a mouse model.
- Injectable polypeptide micelles that form radiation crosslinked hydrogels in situ for intratumoral radiotherapy.
- Injectable tissue integrating networks from recombinant polypeptides with tunable order.
- Interaction of low density lipoproteins with human aortic elastin.
- Interfacial phase transition of an environmentally responsive elastin biopolymer adsorbed on functionalized gold nanoparticles studied by colloidal surface plasmon resonance.
- Maladaptive matrix remodeling and regional biomechanical dysfunction in a mouse model of aortic valve disease.
- Maleimide-Functionalized Poly(2-Oxazoline)s and Their Conjugation to Elastin-Like Polypeptides.
- Micellar Self-Assembly of Recombinant Resilin-/Elastin-Like Block Copolypeptides.
- Microcantilever sensing and actuation with end-grafted stimulus-responsive elastin-like polypeptides.
- Molecular description of the LCST behavior of an elastin-like polypeptide.
- Morphing low-affinity ligands into high-avidity nanoparticles by thermally triggered self-assembly of a genetically encoded polymer.
- Multifunctional thermally transitioning oligopeptides prepared by ring-opening metathesis polymerization.
- Near-infrared spectrometry of abdominal aortic aneurysm in the ApoE-/- mouse.
- Neural network analysis identifies scaffold properties necessary for in vitro chondrogenesis in elastin-like polypeptide biopolymer scaffolds.
- Nitroxide conjugate of a thermally responsive elastin-like polypeptide for noninvasive thermometry.
- Non-chromatographic purification of recombinant elastin-like polypeptides and their fusions with peptides and proteins from Escherichia coli.
- Noncanonical self-assembly of highly asymmetric genetically encoded polypeptide amphiphiles into cylindrical micelles.
- Orientation of elastic fibers in the human cervix.
- Phase Behavior and Self-Assembly of Perfectly Sequence-Defined and Monodisperse Multiblock Copolypeptides.
- Photo-Crosslinkable Unnatural Amino Acids Enable Facile Synthesis of Thermoresponsive Nano- to Microgels of Intrinsically Disordered Polypeptides.
- Postnatal estradiol up-regulates lung nitric oxide synthases and improves lung function in bronchopulmonary dysplasia.
- Predicting transition temperatures of elastin-like polypeptide fusion proteins.
- Protein polymer hydrogels by in situ, rapid and reversible self-gelation.
- Protein purification by fusion with an environmentally responsive elastin-like polypeptide: effect of polypeptide length on the purification of thioredoxin.
- Purification of an elastin-like fusion protein by microfiltration.
- Purification of recombinant proteins by fusion with thermally-responsive polypeptides.
- Quantification of the effects of chain length and concentration on the thermal behavior of elastin-like polypeptides.
- Quantitative model of the phase behavior of recombinant pH-responsive elastin-like polypeptides.
- Quantitative ultrastructural analysis of perifibrous lipid and its association with elastin in nonatherosclerotic human aorta.
- Rapid cross-linking of elastin-like polypeptides with (hydroxymethyl)phosphines in aqueous solution.
- Rational design of "heat seeking" drug loaded polypeptide nanoparticles that thermally target solid tumors.
- Recursive directional ligation by plasmid reconstruction allows rapid and seamless cloning of oligomeric genes.
- Rheological properties of cysteine-containing elastin-like polypeptide solutions and hydrogels.
- Role of Matrix Metalloproteinases-1 and -2 in Interleukin-13-Suppressed Elastin in Airway Fibroblasts in Asthma.
- SMAD3 deficiency promotes vessel wall remodeling, collagen fiber reorganization and leukocyte infiltration in an inflammatory abdominal aortic aneurysm mouse model.
- Self-assembled hybrid elastin-like polypeptide/silica nanoparticles enable triggered drug release.
- Self-assembly of monodisperse oligonucleotide-elastin block copolymers into stars and compound micelles.
- Self-cleavable stimulus responsive tags for protein purification without chromatography.
- Sequence Directionality Dramatically Affects LCST Behavior of Elastin-Like Polypeptides.
- Solar elastosis in cutaneous melanoma.
- Stimulus responsive elastin biopolymers: Applications in medicine and biotechnology.
- Structural analysis of some soluble elastins by means of FT-IR and 2D IR correlation spectroscopy.
- Structural optimization of a "smart" doxorubicin-polypeptide conjugate for thermally targeted delivery to solid tumors.
- Sustained intra-articular delivery of IL-1RA from a thermally-responsive elastin-like polypeptide as a therapy for post-traumatic arthritis.
- Synthesis and characterization of a thermally-responsive tumor necrosis factor antagonist.
- Synthesis and in vitro evaluation of enzymatically cross-linked elastin-like polypeptide gels for cartilaginous tissue repair.
- Targeted drug delivery by thermally responsive polymers.
- Targeting a genetically engineered elastin-like polypeptide to solid tumors by local hyperthermia.
- Temperature sensitive peptides: engineering hyperthermia-directed therapeutics.
- Temperature triggered self-assembly of polypeptides into multivalent spherical micelles.
- The Weak Link: Optimization of the Ligand-Nanoparticle Interface To Enhance Cancer Cell Targeting by Polymer Micelles.
- The content of elastin in the uterine cervix.
- Thermal cycling enhances the accumulation of a temperature-sensitive biopolymer in solid tumors.
- Three-dimensional structures of uterine elastic fibers: scanning electron microscopic studies.
- Three-in-one chromatography-free purification, tag removal, and site-specific modification of recombinant fusion proteins using sortase A and elastin-like polypeptides.
- Thrombospondin-1 is required for normal murine pulmonary homeostasis and its absence causes pneumonia.
- Tracking the in vivo fate of recombinant polypeptides by isotopic labeling.
- Ultra-high expression of a thermally responsive recombinant fusion protein in E. coli.
- Unexpected multivalent display of proteins by temperature triggered self-assembly of elastin-like polypeptide block copolymers.