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Subject Areas on Research
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4.5 kb of the rat tyrosine hydroxylase 5' flanking sequence directs tissue specific expression during development and contains consensus sites for multiple transcription factors.
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5' UTR m(6)A Promotes Cap-Independent Translation.
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A Molecular Switch Regulating Cell Fate Choice between Muscle Progenitor Cells and Brown Adipocytes.
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A common ankyrin-G-based mechanism retains KCNQ and NaV channels at electrically active domains of the axon.
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A de novo deafwaddler mutation of Pmca2 arising in ES cells and hitchhiking with a targeted modification of the Pparg gene.
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A kinome RNAi screen identified AMPK as promoting poxvirus entry through the control of actin dynamics.
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A pathway of neuronal apoptosis induced by hypoxia/reoxygenation: roles of nuclear factor-kappaB and Bcl-2.
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A sensitized mutagenesis screen identifies Gli3 as a modifier of Sox10 neurocristopathy.
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A transgenic DND1GFP fusion allele reports in vivo expression and RNA-binding targets in undifferentiated mouse germ cells†.
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A tyrosine hydroxylase-yellow fluorescent protein knock-in reporter system labeling dopaminergic neurons reveals potential regulatory role for the first intron of the rodent tyrosine hydroxylase gene.
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ABI2-deficient mice exhibit defective cell migration, aberrant dendritic spine morphogenesis, and deficits in learning and memory.
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Abeta42 neurotoxicity in primary co-cultures: effect of apoE isoform and Abeta conformation.
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Abl tyrosine kinases regulate cell-cell adhesion through Rho GTPases.
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Ablation of calcineurin Aβ reveals hyperlipidemia and signaling cross-talks with phosphodiesterases.
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Active staining of mouse embryos for magnetic resonance microscopy.
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Adaptive mechanisms that preserve cardiac function in mice without myoglobin.
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An ultrastructural study of C-type virion assembly in mouse cells.
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Analysis of the Conditions That Affect the Selective Processing of Endogenous Notch1 by ADAM10 and ADAM17.
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Analyzing somatosensory axon projections with the sensory neuron-specific Advillin gene.
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Antillatoxin, a novel lipopeptide, enhances neurite outgrowth in immature cerebrocortical neurons through activation of voltage-gated sodium channels.
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Aurora-A kinase is essential for bipolar spindle formation and early development.
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Axonal Odorant Receptors Mediate Axon Targeting.
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BMP antagonism is required in both the node and lateral plate mesoderm for mammalian left-right axis establishment.
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BMP antagonism protects Nodal signaling in the gastrula to promote the tissue interactions underlying mammalian forebrain and craniofacial patterning.
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BMP receptor IA is required in mammalian neural crest cells for development of the cardiac outflow tract and ventricular myocardium.
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BMP receptor IA is required in the mammalian embryo for endodermal morphogenesis and ectodermal patterning.
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Beta-arrestin1 mediates insulin-like growth factor 1 (IGF-1) activation of phosphatidylinositol 3-kinase (PI3K) and anti-apoptosis.
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Biophysical properties of the zona pellucida measured by capillary suction: is zona hardening a mechanical phenomenon?
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Biosynthesis and in vivo localization of the decapentaplegic-Vg-related protein, DVR-6 (bone morphogenetic protein-6).
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Bone morphogenetic protein signaling is required in the dorsal neural folds before neurulation for the induction of spinal neural crest cells and dorsal neurons.
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CBX2 is required to stabilize the testis pathway by repressing Wnt signaling.
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CHMP5 is essential for late endosome function and down-regulation of receptor signaling during mouse embryogenesis.
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Calcium influx through L-type CaV1.2 Ca2+ channels regulates mandibular development.
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Cardiac-specific LIM protein FHL2 modifies the hypertrophic response to beta-adrenergic stimulation.
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Cartilage-specific β-catenin signaling regulates chondrocyte maturation, generation of ossification centers, and perichondrial bone formation during skeletal development.
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Cell cycle control during early embryogenesis.
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Cell interactions modulate embryonal carcinoma cell differentiation into parietal or visceral endoderm.
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Cell surface-associated proteins which bind native type IV collagen or gelatin.
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Cell-cell adhesions and cell contractility are upregulated upon desmosome disruption.
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Characterization of a rat type 2 angiotensin II receptor stably expressed in 293 cells.
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Chlorpyrifos elicits mitotic abnormalities and apoptosis in neuroepithelium of cultured rat embryos.
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Chondrogenic differentiation of human embryonic stem cell-derived cells in arginine-glycine-aspartate-modified hydrogels.
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Co-expression of vimentin and cytokeratins in parietal endoderm cells of early mouse embryo.
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Comparison of the potency of competitive NMDA antagonists against the neurotoxicity of glutamate and NMDA.
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Concerted morphogenesis of genital ridges and nephric ducts in the mouse captured through whole-embryo imaging.
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Conservation of dishevelled structure and function between flies and mice: isolation and characterization of Dvl2.
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Conserved and divergent expression dynamics during early patterning of the telencephalon in mouse and chick embryos.
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Cortical inhibition modified by embryonic neural precursors grafted into the postnatal brain.
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Current technology for the derivation of pluripotent stem cell lines from human embryos.
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Cytochrome c deficiency causes embryonic lethality and attenuates stress-induced apoptosis.
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Cytoplasmic localization of the transforming protein of Fujinami sarcoma virus: salt-sensitive association with subcellular components.
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DNA methylation in epigenetic control of gene expression.
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Dax1 regulates testis cord organization during gonadal differentiation.
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Defective prolactin signaling impairs pancreatic β-cell development during the perinatal period.
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Delta-like 1-Lysine613 regulates notch signaling.
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Desmoplakin: an unexpected regulator of microtubule organization in the epidermis.
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Development of blobs in the visual cortex of macaques.
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Developmental and spatial patterns of expression of the mouse homeobox gene, Hox 2.1.
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Developmental and transformation-sensitive expression of the Sparc gene on mouse chromosome 11.
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Developmental defects in mouse embryos lacking N-cadherin.
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Developmental expression of tissue inhibitor of metalloproteinase (TIMP) RNA.
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Diacylglycerol kinase zeta regulates actin cytoskeleton reorganization through dissociation of Rac1 from RhoGDI.
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Differential regulation of cAMP by endogenous versus transfected formylpeptide chemoattractant receptors: implications for Gi-coupled receptor signaling.
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Disruption of Arp2/3 results in asymmetric structural plasticity of dendritic spines and progressive synaptic and behavioral abnormalities.
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Disruption of Fgf13 causes synaptic excitatory-inhibitory imbalance and genetic epilepsy and febrile seizures plus.
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Distinct regulatory mechanisms governing embryonic versus adult adipocyte maturation.
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Distinctions in the specificity of E2F function revealed by gene expression signatures.
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Distribution of expression of 2AR (osteopontin) in the embryonic mouse inner ear revealed by in situ hybridisation.
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Effect of halothane in cortical cell cultures exposed to N-methyl-D-aspartate.
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Efficacy and safety of ganirelix acetate versus leuprolide acetate in women undergoing controlled ovarian hyperstimulation.
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Embryo implantation in in vitro fertilization and intracytoplasmic sperm injection: impact of cleavage status, morphology grade, and number of embryos transferred.
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Embryo research revisited.
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Embryonic development of human transplantation antigens.
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Embryonic expression of Lim-1, the mouse homolog of Xenopus Xlim-1, suggests a role in lateral mesoderm differentiation and neurogenesis.
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Embryonic expression of a haematopoietic growth factor encoded by the Sl locus and the ligand for c-kit.
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Embryonic expression of mouse bone morphogenetic protein-1 (BMP-1), which is related to the Drosophila dorsoventral gene tolloid and encodes a putative astacin metalloendopeptidase.
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Embryonic germ cells are capable of adipogenic differentiation in vitro and in vivo.
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Engineering musculoskeletal tissues with human embryonic germ cell derivatives.
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Establishing the epigenetic status of the Prader-Willi/Angelman imprinting center in the gametes and embryo.
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Evidence from molecular cloning that SPARC, a major product of mouse embryo parietal endoderm, is related to an endothelial cell 'culture shock' glycoprotein of Mr 43,000.
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Evolution and development of the mammalian dentition: insights from the marsupial Monodelphis domestica.
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Experience with subzonal insemination (SUZI) and intracytoplasmic sperm injection (ICSI) on unfertilized aged human oocytes.
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Expression and localization of components of the histone deacetylases multiprotein repressory complexes in the mouse preimplantation embryo.
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Expression and modification of Hox 2.1 protein in mouse embryos.
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Expression of Ca(2+)/calmodulin-dependent protein kinase IV (caMKIV) messenger RNA during murine embryogenesis.
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Expression of a murine cytomegalovirus early-late protein in "latently" infected mice.
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Expression of transforming growth factor beta 2 RNA during murine embryogenesis.
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Failure of terminal erythroid differentiation in EKLF-deficient mice is associated with cell cycle perturbation and reduced expression of E2F2.
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Fetal alcohol exposure impairs Hedgehog cholesterol modification and signaling.
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Fetal and adolescent nicotine administration: effects on CNS serotonergic systems.
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Fgf8 is required for anterior heart field development.
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Freezing techniques and results.
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From embryo to teratocarcinoma in tissue culture.
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Functional complementation between FADD and RIP1 in embryos and lymphocytes.
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Fusion of the termini of the murine cytomegalovirus genome after infection.
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GATA6 levels modulate primitive endoderm cell fate choice and timing in the mouse blastocyst.
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Gata3 loss leads to embryonic lethality due to noradrenaline deficiency of the sympathetic nervous system.
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Gene silencing using RNA interference in embryonic stem cells.
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Generation of primary tumors with Flp recombinase in FRT-flanked p53 mice.
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Genome-wide CRISPR Screen to Identify Genes that Suppress Transformation in the Presence of Endogenous KrasG12D.
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Genomic locus modulating corneal thickness in the mouse identifies POU6F2 as a potential risk of developing glaucoma.
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Global analysis of microRNA target gene expression reveals that miRNA targets are lower expressed in mature mouse and Drosophila tissues than in the embryos.
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Glucocorticoid administration alters nuclear transcription factors in fetal rat brain: implications for the use of antenatal steroids.
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Glutamine enhances heat shock protein 70 expression via increased hexosamine biosynthetic pathway activity.
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Growth rate of control and beta-interferon-treated human fibroblast populations over the course of their in vitro life span.
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HNF-3 beta as a regulator of floor plate development.
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Hepcidin induction by transgenic overexpression of Hfe does not require the Hfe cytoplasmic tail, but does require hemojuvelin.
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High-efficiency, long-term cardiac expression of foreign genes in living mouse embryos and neonates.
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High-resolution magnetic resonance histology of the embryonic and neonatal mouse: a 4D atlas and morphologic database.
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Homer modulates NFAT-dependent signaling during muscle differentiation.
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How vinculin regulates force transmission.
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Human embryos derived from in vitro and in vivo matured oocytes: analysis for chromosomal abnormalities and nuclear morphology.
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Human immunodeficiency virus type 1 Vpr-binding protein VprBP, a WD40 protein associated with the DDB1-CUL4 E3 ubiquitin ligase, is essential for DNA replication and embryonic development.
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Immuno-characterization of the switch of peptide elongation factors eEF1A-1/EF-1alpha and eEF1A-2/S1 in the central nervous system during mouse development.
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Immunofluorescence localization of an adducin-like protein in the chromosomes of mouse oocytes.
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Impact of intracytoplasmic sperm injection on embryo cryopreservation and clinical outcome.
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In situ hybridization analysis of TGF beta 3 RNA expression during mouse development: comparative studies with TGF beta 1 and beta 2.
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In vitro synthesis of type IV procollagen.
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Incorporation into Reichert's membrane of laminin-like extracellular proteins synthesized by parietal endoderm cells of the mouse embryo.
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Induction of apoptosis in vascular smooth muscle cells by mechanical stretch.
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Influence of number of pre-embryos transferred, progesterone level and oestradiol/progesterone ratio at thaw on pregnancy results during replacement of cryopreserved pre-embryos in natural cycles.
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Intravital imaging of mouse embryos.
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Isolation of a human teratoma cell line which expresses F9 antigen.
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Isolation of cDNA clones for basal lamina components: type IV procollagen.
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J. P. Hill and Katherine Watson's studies of the neural crest in marsupials.
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LKB1 reduces ROS-mediated cell damage via activation of p38.
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Lineage-specific laminar organization of cortical GABAergic interneurons.
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Localization and phosphorylation of Abl-interactor proteins, Abi-1 and Abi-2, in the developing nervous system.
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Loss of Mafb and Maf distorts myeloid cell ratios and disrupts fetal mouse testis vascularization and organogenesis†.
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Magnetic resonance imaging of embryos: an Internet resource for the study of embryonic development.
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Magnetic resonance microscopy of embryos.
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Mechanical injury to neuronal/glial cultures in microplates: role of NMDA receptors and pH in secondary neuronal cell death.
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Mesothelium contributes to vascular smooth muscle and mesenchyme during lung development.
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Metabolic regulation of protein N-alpha-acetylation by Bcl-xL promotes cell survival.
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Methionine metabolism is essential for SIRT1-regulated mouse embryonic stem cell maintenance and embryonic development.
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MiR-106a-5p modulates apoptosis and metabonomics changes by TGF-β/Smad signaling pathway in cleft palate.
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Misexpression of ptf1a in cortical pyramidal cells in vivo promotes an inhibitory peptidergic identity.
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Mitochondrial phosphatase PTPMT1 is essential for cardiolipin biosynthesis.
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Modulation of BMP signaling by Noggin is required for the maintenance of palatal epithelial integrity during palatogenesis.
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Molecular analysis of genetic instability caused by chronic inflammation.
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Motor deficits are triggered by reperfusion-reoxygenation injury as diagnosed by MRI and by a mechanism involving oxidants.
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Mouse models of Casc3 reveal developmental functions distinct from other components of the exon junction complex.
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Mouse primordial germ cells: isolation and in vitro culture.
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Mouse small eye results from mutations in a paired-like homeobox-containing gene.
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Multiple phenotypic changes in mice after knockout of the B3gnt5 gene, encoding Lc3 synthase--a key enzyme in lacto-neolacto ganglioside synthesis.
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Multi‑organ assessment via a 9.4‑Tesla MRS evaluation of metabolites during the embryonic development of cleft palate induced by dexamethasone.
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NF-kappaB RelA opposes epidermal proliferation driven by TNFR1 and JNK.
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NIEHS/EPA Workshops. Growth and differentiation factors.
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NIEHS/EPA Workshops. Pattern formation.
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Neocortical disynaptic inhibition requires somatodendritic integration in interneurons.
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Neurod6 expression defines new retinal amacrine cell subtypes and regulates their fate.
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Neurosteroid modulation of embryonic neuronal survival in vitro following anoxia.
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Nicotine evokes cell death in embryonic rat brain during neurulation.
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Nicotine inhibits voltage-dependent sodium channels and sensitizes vanilloid receptors.
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Nonhuman primate models of intrauterine cytomegalovirus infection.
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Normal development of the human female reproductive tract and alterations resulting from experimental exposure to diethylstilbestrol.
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Notch signaling maintains Leydig progenitor cells in the mouse testis.
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Notch signaling maintains bone marrow mesenchymal progenitors by suppressing osteoblast differentiation.
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Nrf2-mediated protection against 6-hydroxydopamine.
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Numb regulates somatic cell lineage commitment during early gonadogenesis in mice.
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Oct4 RNA interference induces trophectoderm differentiation in mouse embryonic stem cells.
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Oesophageal and sternohyal muscle fibres are novel Pax3-dependent migratory somite derivatives essential for ingestion.
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Ontogenesis of prolactin receptors in the human fetus in early gestation. Implications for tissue differentiation and development.
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Ontogenetic and phylogenetic transformations of the ear ossicles in marsupial mammals.
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Optical coherence tomography guided microinjections in live mouse embryos: high-resolution targeted manipulation for mouse embryonic research.
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PMS2 endonuclease activity has distinct biological functions and is essential for genome maintenance.
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Peritubular myoid cells are not the migrating population required for testis cord formation in the XY gonad.
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Phosphorylation at tyrosine 262 promotes GADD34 protein turnover.
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Precise pattern of recombination in serotonergic and hypothalamic neurons in a Pdx1-cre transgenic mouse line.
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Predictive value of pregnancy during original in vitro fertilization cycle on implantation and pregnancy in subsequent cryothaw cycles.
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Prenatal choline deficiency decreases the cross-sectional area of cholinergic neurons in the medial septal nucleus.
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Prenatal hypoxia decreases lung extracellular superoxide dismutase expression and activity.
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Progesterone receptor signaling in the initiation of pregnancy and preservation of a healthy uterus.
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Protection of mice from Semliki Forest virus infection by lymphocytes treated with low levels of interferon.
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Protein farnesyltransferase in embryogenesis, adult homeostasis, and tumor development.
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Rac1 activation controls nuclear localization of beta-catenin during canonical Wnt signaling.
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Rapid dendritic transport of TGN38, a putative cargo receptor.
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Reciprocal regulation of angiotensin receptor-activated extracellular signal-regulated kinases by beta-arrestins 1 and 2.
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Reduced cortical BDNF expression and aberrant memory in Carf knock-out mice.
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Regulation of early adipose commitment by Zfp521.
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Relationship between pre-embryo pronuclear morphology (zygote score) and standard day 2 or 3 embryo morphology with regard to assisted reproductive technique outcomes.
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Rescue of Methyl-CpG Binding Protein 2 Dysfunction-induced Defects in Newborn Neurons by Pentobarbital.
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Response to the letter of Hanley et al. ([1999] Teratology 59:323-324), concerning the article by Roy et al. ([1998] Teratology 58:62-68).
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Restricted expression of type-II TGF beta receptor in murine embryonic development suggests a central role in tissue modeling and CNS patterning.
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Retinoic acid induction and regional differentiation prefigure olfactory pathway formation in the mammalian forebrain.
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Retrograde BMP signaling regulates trigeminal sensory neuron identities and the formation of precise face maps.
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Rho GDP dissociation inhibitor-mediated disruption of Rho GTPase activity impairs lens fiber cell migration, elongation and survival.
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Roles for inositol polyphosphate kinases in the regulation of nuclear processes and developmental biology.
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Roles of bone morphogenetic protein signaling and its antagonism in holoprosencephaly.
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Roles of cadherins in patterning of the developing brain.
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SNP array-based analyses of unbalanced embryos as a reference to distinguish between balanced translocation carrier and normal blastocysts.
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SRD5A3 is required for converting polyprenol to dolichol and is mutated in a congenital glycosylation disorder.
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Selective expression of the small GTPase RhoB in the early developing mouse lens.
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Sequential roles of Hedgehog and Wnt signaling in osteoblast development.
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Sex differences in microglial colonization of the developing rat brain.
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Small eye (Sey): a mouse model for the genetic analysis of craniofacial abnormalities.
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Surrogate tolerogenesis: possible pretransplant induction of accommodation of pig xenografts.
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T1 rho relaxation and its application to MR histology.
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TRPC6 expression in neurons is differentially regulated by NR2A- and NR2B-containing NMDA receptors.
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Targeted Epigenetic Remodeling of Endogenous Loci by CRISPR/Cas9-Based Transcriptional Activators Directly Converts Fibroblasts to Neuronal Cells.
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Targeted deletion of 5'HS2 of the murine beta-globin LCR reveals that it is not essential for proper regulation of the beta-globin locus.
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Targeted disruption of the mouse gene encoding steroidogenic acute regulatory protein provides insights into congenital lipoid adrenal hyperplasia.
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Targeting inhibition of GluR1 Ser845 phosphorylation with an RNA aptamer that blocks AMPA receptor trafficking.
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Targeting lysosomal degradation induces p53-dependent cell death and prevents cancer in mouse models of lymphomagenesis.
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Tau--an inhibitor of deacetylase HDAC6 function.
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Testis formation in the fetal mouse: dynamic and complex de novo tubulogenesis.
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The EJC component Magoh regulates proliferation and expansion of neural crest-derived melanocytes.
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The Ethics of Experimenting With Human Brain Tissue
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The RGD motif in fibronectin is essential for development but dispensable for fibril assembly.
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The RNA-binding protein DND1 acts sequentially as a negative regulator of pluripotency and a positive regulator of epigenetic modifiers required for germ cell reprogramming.
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The adaptor protein beta-arrestin2 enhances endocytosis of the low density lipoprotein receptor.
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The autonomous activity of calcium/calmodulin-dependent protein kinase IV is required for its role in transcription.
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The effects of high-dose toluene on embryonic development in the rat.
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The exon junction complex component Magoh controls brain size by regulating neural stem cell division.
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The forkhead genes, Foxc1 and Foxc2, regulate paraxial versus intermediate mesoderm cell fate.
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The inhibition of differentiation caused by TGFbeta in fetal myoblasts is dependent upon selective expression of PKCtheta: a possible molecular basis for myoblast diversification during limb histogenesis.
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The iron exporter ferroportin/Slc40a1 is essential for iron homeostasis.
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The mammalian class 3 PI3K (PIK3C3) is required for early embryogenesis and cell proliferation.
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The requirement of SUMO2/3 for SENP2 mediated extraembryonic and embryonic development.
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The tau N279K exon 10 splicing mutation recapitulates frontotemporal dementia and parkinsonism linked to chromosome 17 tauopathy in a mouse model.
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The transcription factor calcium-response factor limits NMDA receptor-dependent transcription in the developing brain.
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Three-dimensional structure of the developing mouse genital ridge.
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Thrombospondin receptor α2δ-1 promotes synaptogenesis and spinogenesis via postsynaptic Rac1.
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Time-course imaging of rat embryos in utero with magnetic resonance microscopy.
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Timing and irreversibility of Müllerian duct inhibition in the embryonic reproductive tract of the human male.
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Tissue-specific expression in mammalian brain, heart, and muscle of S1, a member of the elongation factor-1 alpha gene family.
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Transcription factors MYOCD, SRF, Mesp1 and SMARCD3 enhance the cardio-inducing effect of GATA4, TBX5, and MEF2C during direct cellular reprogramming.
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Transcription in mouse embryo cells permissively infected by murine cytomegalovirus.
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Transcription of H-2 and Qa genes in embryonic and adult mice.
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Transcriptome analysis of mouse stem cells and early embryos.
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Transcriptome profiling of genes involved in neural tube closure during human embryonic development using long serial analysis of gene expression (long-SAGE).
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Transferrin receptor is necessary for development of erythrocytes and the nervous system.
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Transgenic indicator mice for studying activated retinoic acid receptors during development.
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Transient neurites of retinal horizontal cells exhibit columnar tiling via homotypic interactions.
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Transplantation of embryonic stem cells into the infarcted mouse heart: formation of multiple cell types.
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Treating cancer with embryonic stem cells: rationale comes from aging studies.
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Two mouse early embryonic beta-globin gene sequences. Evolution of the nonadult beta-globins.
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Ubiquitous expression of mRFP1 in transgenic mice.
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Unc-51-like kinase 1/2-mediated endocytic processes regulate filopodia extension and branching of sensory axons.
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Use of human gametes obtained from anonymous donors for the production of human embryonic stem cell lines.
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Using human neural stem cells to model neurological disease.
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VCP is essential for mitochondrial quality control by PINK1/Parkin and this function is impaired by VCP mutations.
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Whole Mount In Situ Hybridization in Murine Tissues.
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[Potential role of presenilin 1 in regulation of synaptic function].
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beta -Arrestins regulate protease-activated receptor-1 desensitization but not internalization or Down-regulation.
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beta-Adrenergic modulation of muscarinic cholinergic receptor expression and function in developing heart.
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beta-Catenin protects the epidermis from mechanical stresses.
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Keywords of People
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Erickson, Harold Paul,
James B. Duke Distinguished Professor Emeritus,
Cell Biology
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Freemark, Michael Scott,
Robert C. Atkins, M.D. and Veronica Atkins Distinguished Professor of Pediatrics, in the School of Medicine,
Pediatrics, Endocrinology
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Hilton, Matthew James,
Associate Professor in Orthopaedic Surgery,
Cell Biology
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Hogan, Brigid L. M.,
Research Professor of Cell Biology,
Cell Biology
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Johnson, G. Allan,
Charles E. Putman University Distinguished Professor of Radiology,
Biomedical Engineering
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McLendon, Roger Edwin,
Professor of Pathology,
Pathology
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Silver, Debra Lynn,
Associate Professor of Molecular Genetics and Microbiology,
Duke Science & Society
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Sullivan, Daniel Carl,
Professor Emeritus of Radiology,
Radiology
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Velkey, John Matthew,
Assistant Professor of the Practice of Medical Education in the Department of Cell Biology,
Cell Biology