Endocytosis

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  Subject Areas on Research

  • A Fluorescent Hsp90 Probe Demonstrates the Unique Association between Extracellular Hsp90 and Malignancy in Vivo. 
  • A carcinoembryonic antigen (CEA) binding protein from ascites influences CEA uptake by macrophages. 
  • A central role for beta-arrestins and clathrin-coated vesicle-mediated endocytosis in beta2-adrenergic receptor resensitization. Differential regulation of receptor resensitization in two distinct cell types. 
  • A combination of two immunotoxins exerts synergistic cytotoxic activity against human breast-cancer cell lines. 
  • A common clathrin-mediated machinery co-ordinates cell-cell adhesion and bacterial internalization. 
  • A differential role for endocytosis in receptor-mediated activation of Nox1. 
  • A missense mutation in TFRC, encoding transferrin receptor 1, causes combined immunodeficiency. 
  • A mutation of the beta 2-adrenergic receptor impairs agonist activation of adenylyl cyclase without affecting high affinity agonist binding. Distinct molecular determinants of the receptor are involved in physical coupling to and functional activation of Gs. 
  • A quantitative study of the intracellular fate of pH-responsive doxorubicin-polypeptide nanoparticles. 
  • A requirement for ankyrin binding to clathrin during coated pit budding. 
  • A role for myocilin in receptor-mediated endocytosis. 
  • A unique protein kinase C-dependent pathway for tissue factor downregulation in pericytes. 
  • ALK1 regulates the internalization of endoglin and the type III TGF-β receptor. 
  • ARF1 regulates Nef-induced CD4 degradation. 
  • ASTN2 modulates synaptic strength by trafficking and degradation of surface proteins. 
  • Abi-1 forms an epidermal growth factor-inducible complex with Cbl: role in receptor endocytosis. 
  • Abl tyrosine kinase regulates endocytosis of the epidermal growth factor receptor. 
  • Activation-induced endocytosis of the raft-associated transmembrane adaptor protein LAB/NTAL in B lymphocytes: evidence for a role in internalization of the B cell receptor. 
  • Activity-dependent internalization of smoothened mediated by beta-arrestin 2 and GRK2. 
  • Acute and chronic phagocyte determinants of cardiac allograft vasculopathy. 
  • Adjuvant-free in vivo targeting. Antigen delivery by alpha 2-macroglobulin enhances antibody formation. 
  • Agonist-dependent recruitment of phosphoinositide 3-kinase to the membrane by beta-adrenergic receptor kinase 1. A role in receptor sequestration. 
  • Agonist-stimulated beta-adrenergic receptor internalization requires dynamic cytoskeletal actin turnover. 
  • Alpha 2-macroglobulin binds CpG oligodeoxynucleotides and enhances their immunostimulatory properties by a receptor-dependent mechanism. 
  • Alpha 2-macroglobulin: a sensor for proteolysis. 
  • Altered interaction of Cis-dichlorodiammineplatinum(II)--modified alpha 2-macroglobulin (alpha 2M) with the low density lipoprotein receptor-related protein/alpha 2M receptor but not the alpha 2M signaling receptor. 
  • Altering integrin engagement regulates membrane localization of Kir2.1 channels. 
  • An internalization signal in the simian immunodeficiency virus transmembrane protein cytoplasmic domain modulates expression of envelope glycoproteins on the cell surface. 
  • Analysis of hydrostatic pressure-induced changes in umbrella cell surface area. 
  • Anchorage of VEGF to the extracellular matrix conveys differential signaling responses to endothelial cells 
  • Ankyrin-G Inhibits Endocytosis of Cadherin Dimers. 
  • Anti-synthetic peptide antibody reacting at the fusion junction of deletion-mutant epidermal growth factor receptors in human glioblastoma. 
  • Apical and basolateral endocytic pathways of MDCK cells meet in acidic common endosomes distinct from a nearly-neutral apical recycling endosome. 
  • Apolipoprotein E and Alzheimer's disease: signal transduction mechanisms. 
  • Aptamer-mediated delivery of chemotherapy to pancreatic cancer cells. 
  • Aptamer-mediated delivery of splice-switching oligonucleotides to the nuclei of cancer cells. 
  • Arrestins come of age: a personal historical perspective. 
  • Association of beta-arrestin with G protein-coupled receptors during clathrin-mediated endocytosis dictates the profile of receptor resensitization. 
  • Attenuation of acid induced oesophagitis in VR-1 deficient mice. 
  • Axl2 integrates polarity establishment, maintenance, and environmental stress response in the filamentous fungus Ashbya gossypii. 
  • Axon regeneration pathways identified by systematic genetic screening in C. elegans. 
  • B cell antigen receptor endocytosis and antigen presentation to T cells require Vav and dynamin. 
  • Beta-Arrestins: new roles in regulating heptahelical receptors' functions. 
  • Beta-arrestin 2 mediates endocytosis of type III TGF-beta receptor and down-regulation of its signaling. 
  • Beta-arrestin scaffolding of phosphatidylinositol 4-phosphate 5-kinase Ialpha promotes agonist-stimulated sequestration of the beta2-adrenergic receptor. 
  • Beta-arrestins: multifunctional cellular mediators. 
  • Beyond desensitization: physiological relevance of arrestin-dependent signaling. 
  • Binding and endocytosis of alpha 2-macroglobulin-plasmin complexes. 
  • Biochemical and biophysical identification of cystic fibrosis transmembrane conductance regulator chloride channels as components of endocytic clathrin-coated vesicles. 
  • Blocking the interaction between apolipoprotein E and Aβ reduces intraneuronal accumulation of Aβ and inhibits synaptic degeneration. 
  • CHMP5 is essential for late endosome function and down-regulation of receptor signaling during mouse embryogenesis. 
  • Calmodulin dissociation regulates Myo5 recruitment and function at endocytic sites. 
  • Calmodulin in endocrine cells. 
  • Capsaicin vanilloid receptor-1 mediates substance P release in experimental pancreatitis. 
  • Carcinoembryonic antigen binding proteins on elicited peritoneal macrophages. 
  • Cases from the Osler medical service at Johns Hopkins University. 
  • Cdc2 and Mos regulate Emi2 stability to promote the meiosis I-meiosis II transition. 
  • Cell biology and physiology of the uroepithelium. 
  • Cell biology. Caveolae--not just craters in the cellular landscape. 
  • Cell necrosis and endocytosis (apoptosis) in an embryonal rhabdomyosarcoma of the orbit. 
  • Cell penetration properties of maurocalcine, a natural venom peptide active on the intracellular ryanodine receptor. 
  • Cell surface F1Fo ATP synthase: a new paradigm? 
  • Cell surface localization and density of the tumor-associated variant of the epidermal growth factor receptor, EGFRvIII. 
  • Cell-autonomous adiposity through increased cell surface GLUT4 due to ankyrin-B deficiency. 
  • Cellular cytoskeleton dynamics modulates non-viral gene delivery through RhoGTPases 
  • Cellular trafficking of G protein-coupled receptor/beta-arrestin endocytic complexes. 
  • Chaperone-mediated cross-priming: a hitchhiker's guide to vesicle transport (review). 
  • Chemical Modulation of Endocytic Sorting Augments Adeno-associated Viral Transduction. 
  • Chemical and structural modifications of alpha 2-macroglobulin: effects on receptor binding and endocytosis studied in an in vivo model. 
  • Clathrin is important for normal actin dynamics and progression of Sla2p-containing patches during endocytosis in yeast. 
  • Clathrin light chains are required for the gyrating-clathrin recycling pathway and thereby promote cell migration. 
  • Clathrin-mediated endocytosis of the beta-adrenergic receptor is regulated by phosphorylation/dephosphorylation of beta-arrestin1. 
  • Co-option of endocytic functions of cellular caveolae by pathogens. 
  • Constitutive arrestin-mediated desensitization of a human vasopressin receptor mutant associated with nephrogenic diabetes insipidus. 
  • Constitutively active alpha-1b adrenergic receptor mutants display different phosphorylation and internalization features. 
  • Counteracting signaling activities in lipid rafts associated with the invasion of lung epithelial cells by Pseudomonas aeruginosa. 
  • Coxsackievirus entry across epithelial tight junctions requires occludin and the small GTPases Rab34 and Rab5. 
  • Current Progress in Electrotransfection as a Nonviral Method for Gene Delivery. 
  • Cutting edge: CD91-independent cross-presentation of GRP94(gp96)-associated peptides. 
  • Cytoskeletal dynamics: a view from the membrane. 
  • Defective coupling of apical PTH receptors to phospholipase C prevents internalization of the Na+-phosphate cotransporter NaPi-IIa in Nherf1-deficient mice. 
  • Deletion of PIK3C3/Vps34 in sensory neurons causes rapid neurodegeneration by disrupting the endosomal but not the autophagic pathway. 
  • Delta-like 1-Lysine613 regulates notch signaling. 
  • Desensitization, internalization, and signaling functions of beta-arrestins demonstrated by RNA interference. 
  • Developmental regulation of apical endocytosis controls epithelial patterning in vertebrate tubular organs. 
  • Differential regulation of the dopamine D2 and D3 receptors by G protein-coupled receptor kinases and beta-arrestins. 
  • Differential uptake of DNA–poly (ethylenimine) polyplexes in cells cultured on collagen and fibronectin surfaces 
  • Directionality of wingless protein transport influences epidermal patterning in the Drosophila embryo. 
  • Dishevelled 2 recruits beta-arrestin 2 to mediate Wnt5A-stimulated endocytosis of Frizzled 4. 
  • Distinct conformations of GPCR-β-arrestin complexes mediate desensitization, signaling, and endocytosis. 
  • Distinct effects of endosomal escape and inhibition of endosomal trafficking on gene delivery via electrotransfection. 
  • Distinct roles for β-arrestin2 and arrestin-domain-containing proteins in β2 adrenergic receptor trafficking. 
  • Domains of the parathyroid hormone (PTH) receptor required for regulation by G protein-coupled receptor kinases (GRKs). 
  • Dynamic movements of organelles containing Niemann-Pick C1 protein: NPC1 involvement in late endocytic events. 
  • Dynamin and beta-arrestin reveal distinct mechanisms for G protein-coupled receptor internalization. 
  • Effects of ammonium ion derived from bovine endothelial cells upon low density lipoprotein degradation in cultured vascular smooth muscle cells. 
  • Effects of endocytosis on receptor-mediated signaling. 
  • Effects of pimozide and penfluridol on the binding and endocytosis of alpha 2-macroglobulin-CH3NH2 by mouse peritoneal macrophages. 
  • Emerging paradigms of β-arrestin-dependent seven transmembrane receptor signaling. 
  • Endocytosis and recycling of the T3-T cell receptor complex. The role of T3 phosphorylation. 
  • Endocytosis of G protein-coupled receptors: roles of G protein-coupled receptor kinases and beta-arrestin proteins. 
  • Endocytosis of Red Blood Cell Microparticles by Pulmonary Endothelial Cells is Mediated By Rab5. 
  • Endocytosis of functional epidermal growth factor receptor-green fluorescent protein chimera. 
  • Endocytosis of red blood cells or haemoglobin by activated macrophages inhibits their tumoricidal effect. 
  • Endocytosis of the type III transforming growth factor-beta (TGF-beta) receptor through the clathrin-independent/lipid raft pathway regulates TGF-beta signaling and receptor down-regulation. 
  • Endocytosis proteins and cancer: a potential link? 
  • Enterotoxigenic Escherichia coli vesicles target toxin delivery into mammalian cells. 
  • Essential role for G protein-coupled receptor endocytosis in the activation of mitogen-activated protein kinase. 
  • Evidence of a role for heterotrimeric GTP-binding proteins in endosome fusion. 
  • Expanding roles for beta-arrestins as scaffolds and adapters in GPCR signaling and trafficking. 
  • Fast endocytosis is inhibited by GABA-mediated chloride influx at a presynaptic terminal. 
  • Fetuin-A uptake in bovine vascular smooth muscle cells is calcium dependent and mediated by annexins. 
  • Flg22-induced Ca²⁺ increases undergo desensitization and resensitization. 
  • Fluorine-18 Labeling of the HER2-Targeting Single-Domain Antibody 2Rs15d Using a Residualizing Label and Preclinical Evaluation. 
  • Forward scatter pulse width signals resolve multiple populations of endosomes. 
  • Function and regulation of calmodulin in endocrine cells. 
  • G Protein-Coupled Receptor Endocytosis Confers Uniformity in Responses to Chemically Distinct Ligands. 
  • G Protein-Coupled Receptor Signaling Through β-Arrestin-Dependent Mechanisms. 
  • G protein-coupled receptor (GPCR) signaling via heterotrimeric G proteins from endosomes. 
  • G protein-coupled receptor internalization signaling is required for cardioprotection in ischemic preconditioning. 
  • G protein-coupled receptors mediate two functionally distinct pathways of tyrosine phosphorylation in rat 1a fibroblasts. Shc phosphorylation and receptor endocytosis correlate with activation of Erk kinases. 
  • GPCR desensitization: Acute and prolonged phases. 
  • Gangliosides are essential endosomal receptors for quasi-enveloped and naked hepatitis A virus. 
  • Genetic ablation of phosphatidylinositol transfer protein function in murine embryonic stem cells. 
  • Giant ankyrin-G stabilizes somatodendritic GABAergic synapses through opposing endocytosis of GABAA receptors. 
  • Glycosylphosphatidylinositol-anchored receptor-mediated bacterial endocytosis. 
  • HIV-1 Nef protein binds to the cellular protein PACS-1 to downregulate class I major histocompatibility complexes. 
  • Histone deacetylase 6 regulates growth factor-induced actin remodeling and endocytosis. 
  • Human immunodeficiency virus (HIV) infects human arterial smooth muscle cells in vivo and in vitro: implications for the pathogenesis of HIV-mediated vascular disease. 
  • Human monocytes as intermediaries between allogeneic endothelial cells and allospecific T cells: a role for direct scavenger receptor-mediated endothelial membrane uptake in the initiation of alloimmunity. 
  • Identification of NSF as a beta-arrestin1-binding protein. Implications for beta2-adrenergic receptor regulation. 
  • Identification of a somatodendritic targeting signal in the cytoplasmic domain of the transferrin receptor. 
  • Immunoinhibition of intracellular protein digestion in macrophages. 
  • Improved efficacy of stem cell labeling for magnetic resonance imaging studies by the use of cationic liposomes. 
  • In vitro preparation of nonenzymatically glucosylated human transferrin, alpha 2-macroglobulin, and fibrinogen with preservation of function. 
  • In vivo dynamics of clathrin and its adaptor-dependent recruitment to the actin-based endocytic machinery in yeast. 
  • Ingression of primary mesenchyme cells of the sea urchin embryo: a precisely timed epithelial mesenchymal transition 
  • Inhibiting clathrin-mediated endocytosis of the leucine-rich G protein-coupled receptor-5 diminishes cell fitness. 
  • Inhibition of the receptor-binding function of clathrin adaptor protein AP-2 by dominant-negative mutant mu2 subunit and its effects on endocytosis. 
  • Interaction of CTLA-4 with the clathrin-associated protein AP50 results in ligand-independent endocytosis that limits cell surface expression. 
  • Internalization is essential for the antiapoptotic effects of exogenous thymosin beta-4 on human corneal epithelial cells. 
  • Internalization of fibroblast growth factor receptor is inhibited by a point mutation at tyrosine 766. 
  • Intracellular trafficking of angiotensin II and its AT1 and AT2 receptors: evidence for selective sorting of receptor and ligand. 
  • Intracellular trafficking pathways in silver nanoparticle uptake and toxicity in Caenorhabditis elegans. 
  • Involvement of a Rac1-Dependent Macropinocytosis Pathway in Plasmid DNA Delivery by Electrotransfection. 
  • Involvement of cellular caveolae in bacterial entry into mast cells. 
  • Involvement of dynamin-2 in formation of discoid vesicles in urinary bladder umbrella cells. 
  • Kinetics of poliovirus uncoating in HeLa cells in a nonacidic environment. 
  • MARCH2 promotes endocytosis and lysosomal sorting of carvedilol-bound β(2)-adrenergic receptors. 
  • Mechanisms of cellular protrusions branch out. 
  • Mechanisms of immune stimulation by bacterial DNA. 
  • Membrane Trafficking in Plant Immunity. 
  • Membrane binding of plasmid DNA and endocytic pathways are involved in electrotransfection of mammalian cells. 
  • Metabolic cooperation between vascular endothelial cells and smooth muscle cells in co-culture: changes in low density lipoprotein metabolism. 
  • MinK-dependent internalization of the IKs potassium channel. 
  • Modular nanotransporters for targeted intracellular delivery of drugs: folate receptors as potential targets. 
  • Molecular determinants underlying the formation of stable intracellular G protein-coupled receptor-beta-arrestin complexes after receptor endocytosis*. 
  • Molecular mechanisms of G protein-coupled receptor desensitization and resensitization. 
  • Monocyte chemotactic peptide receptor. Functional characteristics and ligand-induced regulation. 
  • Multifaceted roles for lipids in viral infection. 
  • Multifaceted roles of beta-arrestins in the regulation of seven-membrane-spanning receptor trafficking and signalling. 
  • Multiple endocytic pathways of G protein-coupled receptors delineated by GIT1 sensitivity. 
  • N-formyl peptide receptors internalize but do not recycle in the absence of arrestins. 
  • NHERF: targeting and trafficking membrane proteins. 
  • Neuregulin-induced expression of the acetylcholine receptor requires endocytosis of ErbB receptors. 
  • Neurotrophin Signaling Is Required for Glucose-Induced Insulin Secretion. 
  • Neutrophil activation by nascent FimH subunits of type 1 fimbriae purified from the periplasm of Escherichia coli. 
  • New mechanisms in heptahelical receptor signaling to mitogen activated protein kinase cascades. 
  • New roles for mast cells in pathogen defense and allergic disease. 
  • Notch3 pathway alterations in ovarian cancer. 
  • Notochord vacuoles are lysosome-related organelles that function in axis and spine morphogenesis. 
  • Novel aminoalkyl tris-cyclometalated iridium complexes as cellular stains. 
  • Nucleic acid-binding polymers as anti-inflammatory agents. 
  • Okadaic acid disrupts synaptic vesicle trafficking in a ribbon-type synapse. 
  • Particulate allergens potentiate allergic asthma in mice through sustained IgE-mediated mast cell activation. 
  • Pathophysiology of the blood-brain barrier: animal models and methods. 
  • Pathways Governing Polyethylenimine Polyplex Transfection in Microporous Annealed Particle Scaffolds. 
  • Permeability properties of the mammalian bladder apical membrane. 
  • Pharmacologic disruption of TRPV1-expressing primary sensory neurons but not genetic deletion of TRPV1 protects mice against pancreatitis. 
  • Phenotypic regulation of the sphingosine 1-phosphate receptor miles apart by G protein-coupled receptor kinase 2. 
  • Phorbol myristate acetate stimulates pinocytosis and membrane spreading in mouse peritoneal macrophages. 
  • Phosphoinositide 3-kinase regulates beta2-adrenergic receptor endocytosis by AP-2 recruitment to the receptor/beta-arrestin complex. 
  • Phospholipid membrane composition affects EGF receptor and Notch signaling through effects on endocytosis during Drosophila development. 
  • Phosphorylation of Src by phosphoinositide 3-kinase regulates beta-adrenergic receptor-mediated EGFR transactivation. 
  • Phosphorylation of beta-arrestin2 regulates its function in internalization of beta(2)-adrenergic receptors. 
  • Phosphorylation of the deubiquitinase USP20 by protein kinase A regulates post-endocytic trafficking of β2 adrenergic receptors to autophagosomes during physiological stress. 
  • Physiological implications of the presence, distribution, and regulation of calmodulin in eukaryotic cells. 
  • Picornavirus entry. 
  • Plasma membrane polarization during mating in yeast cells. 
  • Poliovirus entry into human brain microvascular cells requires receptor-induced activation of SHP-2. 
  • Polyclonal HER2-specific antibodies induced by vaccination mediate receptor internalization and degradation in tumor cells. 
  • Properties of secretin receptor internalization differ from those of the beta(2)-adrenergic receptor. 
  • Protease activity of normal and PHA stimulated human lymphocytes. 
  • Protective astrogenesis from the SVZ niche after injury is controlled by Notch modulator Thbs4. 
  • Protein kinase A and G protein-coupled receptor kinase phosphorylation mediates beta-1 adrenergic receptor endocytosis through different pathways. 
  • Protein kinase activity of phosphoinositide 3-kinase regulates beta-adrenergic receptor endocytosis. 
  • RAB-10-Dependent Membrane Transport Is Required for Dendrite Arborization. 
  • RNA interference and single particle tracking analysis of hepatitis C virus endocytosis. 
  • Rab11 helps maintain apical crumbs and adherens junctions in the Drosophila embryonic ectoderm. 
  • Rapid dendritic transport of TGN38, a putative cargo receptor. 
  • Rapid endocytosis of a G protein-coupled receptor: substance P evoked internalization of its receptor in the rat striatum in vivo. 
  • Rapid loss of blood-brain barrier P-glycoprotein activity through transporter internalization demonstrated using a novel in situ proteolysis protection assay. 
  • Re-examination of CD91 function in GRP94 (glycoprotein 96) surface binding, uptake, and peptide cross-presentation. 
  • Receptor binding, endocytosis, and mitogenesis of insulin-like growth factors I and II in fetal rat brain neurons. 
  • Receptor endocytosis and dendrite reshaping in spinal neurons after somatosensory stimulation. 
  • Receptor mediated and fluid phase pathways for internalization of the ER Hsp90 chaperone GRP94 in murine macrophages. 
  • Receptor-mediated endocytosis of carcinoembryonic antigen by rat alveolar macrophages in vitro. 
  • Receptor-mediated endocytosis of carcinoembryonic antigen by rat liver Kupffer cells. 
  • Receptor-specific ubiquitination of beta-arrestin directs assembly and targeting of seven-transmembrane receptor signalosomes. 
  • Recombinant human acid alpha-glucosidase corrects acid alpha-glucosidase-deficient human fibroblasts, quail fibroblasts, and quail myoblasts. 
  • Regular structures in unit membranes. II. Morphological and biochemical characterization of two water-soluble membrane proteins isolated from the suckling rat ileum. 
  • Regular structures in unit membranes. III. Further observations on the particulate component of the suckling rat ileum endocytic membrane complex. 
  • Regulation of epidermal growth factor receptor internalization by G protein-coupled receptors. 
  • Regulation of spine structural plasticity by Arc/Arg3.1. 
  • Regulation of the human chemokine receptor CCR1. Cross-regulation by CXCR1 and CXCR2. 
  • Regulation of tyrosine kinase cascades by G-protein-coupled receptors. 
  • Reprogramming tumor-associated dendritic cells in vivo using miRNA mimetics triggers protective immunity against ovarian cancer. 
  • Requirement for JAK/STAT signaling throughout border cell migration in Drosophila. 
  • RhoB-dependent modulation of postendocytic traffic in polarized Madin-Darby canine kidney cells. 
  • Role of Scd5, a protein phosphatase-1 targeting protein, in phosphoregulation of Sla1 during endocytosis. 
  • Role of beta-arrestins in the intracellular trafficking of G-protein-coupled receptors. 
  • Role of endocytosis in the activation of the extracellular signal-regulated kinase cascade by sequestering and nonsequestering G protein-coupled receptors. 
  • Role of the Hof1-Cyk3 interaction in cleavage-furrow ingression and primary-septum formation during yeast cytokinesis. 
  • Roles for endocytic trafficking and phosphatidylinositol 4-kinase III alpha in hepatitis C virus replication. 
  • S-nitrosylation of beta-arrestin regulates beta-adrenergic receptor trafficking. 
  • SREC-I, a type F scavenger receptor, is an endocytic receptor for calreticulin. 
  • Sapap3 deletion causes mGluR5-dependent silencing of AMPAR synapses. 
  • Scara5 is a ferritin receptor mediating non-transferrin iron delivery. 
  • Scd5p and clathrin function are important for cortical actin organization, endocytosis, and localization of sla2p in yeast. 
  • Segmental distribution of the endocytosis receptor gp330 in renal proximal tubules. 
  • Sequestration of T cells in bone marrow in the setting of glioblastoma and other intracranial tumors. 
  • Serotonin 5-HT1A receptor-mediated Erk activation requires calcium/calmodulin-dependent receptor endocytosis. 
  • Signaling at the endosome: cryo-EM structure of a GPCR-G protein-beta-arrestin megacomplex. 
  • Spatial encoding of cyclic AMP signaling specificity by GPCR endocytosis. 
  • Sphingolipids signal heat stress-induced ubiquitin-dependent proteolysis. 
  • Spinophilin blocks arrestin actions in vitro and in vivo at G protein-coupled receptors. 
  • Src-dependent tyrosine phosphorylation regulates dynamin self-assembly and ligand-induced endocytosis of the epidermal growth factor receptor. 
  • Steroid-sensitive nephrotic syndrome candidate gene CLVS1 regulates podocyte oxidative stress and endocytosis. 
  • Stimulation of mitogen-activated protein kinase by G protein-coupled alpha(2)-adrenergic receptors does not require agonist-elicited endocytosis. 
  • Stretch-regulated exocytosis/endocytosis in bladder umbrella cells. 
  • Studies of the multifaceted mast cell response to bacteria. 
  • Synaptic vesicle biogenesis, docking, and fusion: a molecular description. 
  • Synergistic antitumor effects of 9.2.27-PE38KDEL and ABT-737 in primary and metastatic brain tumors. 
  • Synergistic regulation of beta2-adrenergic receptor sequestration: intracellular complement of beta-adrenergic receptor kinase and beta-arrestin determine kinetics of internalization. 
  • The BIN1 rs744373 SNP is associated with increased tau-PET levels and impaired memory. 
  • The C2 domain protein Cts1 functions in the calcineurin signaling circuit during high-temperature stress responses in Cryptococcus neoformans. 
  • The CD19 signal transduction complex of B lymphocytes. Deletion of the CD19 cytoplasmic domain alters signal transduction but not complex formation with TAPA-1 and Leu 13. 
  • The Control Centers of Biomolecular Phase Separation: How Membrane Surfaces, PTMs, and Active Processes Regulate Condensation. 
  • The Functional Landscape of Patient-Derived RNF43 Mutations Predicts Sensitivity to Wnt Inhibition. 
  • The G protein-coupled receptor GPR4 suppresses ERK activation in a ligand-independent manner. 
  • The Snail repressor is required for PMC ingression in the sea urchin embryo. 
  • The adaptor protein beta-arrestin2 enhances endocytosis of the low density lipoprotein receptor. 
  • The anti-helminthic niclosamide inhibits Wnt/Frizzled1 signaling. 
  • The beta(2)-adrenergic receptor mediates extracellular signal-regulated kinase activation via assembly of a multi-receptor complex with the epidermal growth factor receptor. 
  • The beta2-adrenergic receptor/betaarrestin complex recruits the clathrin adaptor AP-2 during endocytosis. 
  • The conformation-dependent interaction of alpha 2-macroglobulin with vascular endothelial growth factor. A novel mechanism of alpha 2-macroglobulin/growth factor binding. 
  • The deubiquitinases USP33 and USP20 coordinate beta2 adrenergic receptor recycling and resensitization. 
  • The effect of hyperbranched polyglycerol coatings on drug delivery using degradable polymer nanoparticles. 
  • The endocytic recycling regulator EHD1 is essential for spermatogenesis and male fertility in mice. 
  • The low density lipoprotein receptor regulates the level of central nervous system human and murine apolipoprotein E but does not modify amyloid plaque pathology in PDAPP mice. 
  • The microtubule-associated histone deacetylase 6 (HDAC6) regulates epidermal growth factor receptor (EGFR) endocytic trafficking and degradation. 
  • The role of lipid rafts in the pathogenesis of bacterial infections. 
  • The type 1 angiotensin II receptor tail affects receptor targeting, internalization, and membrane fusion properties. 
  • Timely Endocytosis of Cytokinetic Enzymes Prevents Premature Spindle Breakage during Mitotic Exit. 
  • Trafficking of G protein-coupled receptors. 
  • Trafficking patterns of beta-arrestin and G protein-coupled receptors determined by the kinetics of beta-arrestin deubiquitination. 
  • Transduction of receptor signals by beta-arrestins. 
  • Transfection in the third dimension 
  • Transfer of GRP94(Gp96)-associated peptides onto endosomal MHC class I molecules. 
  • Transiently expressed ATG16L1 inhibits autophagosome biogenesis and aberrantly targets RAB11-positive recycling endosomes. 
  • Transport of lysosomes decreases in the perinuclear region: Insights from changepoint analysis. 
  • Triphenylmethane dye activation of beta-arrestin. 
  • Tumor cell endocytosis imaging facilitates delineation of the glioma-brain interface. 
  • Two Small Molecules Block Oral Epithelial Cell Invasion by Porphyromons gingivalis. 
  • Ubiquitination of beta-arrestin links seven-transmembrane receptor endocytosis and ERK activation. 
  • Ultrastructural Analysis of Vesicular Transport in Electrotransfection. 
  • Unc-51-like kinase 1/2-mediated endocytic processes regulate filopodia extension and branching of sensory axons. 
  • VEGF internalization is not required for VEGFR-2 phosphorylation in bioengineered surfaces with covalently linked VEGF 
  • Vav and Rac activation in B cell antigen receptor endocytosis involves Vav recruitment to the adapter protein LAB. 
  • Visualizing receptor endocytosis and trafficking. 
  • WNT Activates the AAK1 Kinase to Promote Clathrin-Mediated Endocytosis of LRP6 and Establish a Negative Feedback Loop. 
  • Wsp1 is downstream of Cin1 and regulates vesicle transport and actin cytoskeleton as an effector of Cdc42 and Rac1 in Cryptococcus neoformans. 
  • [Endocytosis and receptors: molecular and physiological aspects]. 
  • beta-Arrestin 1 and Galphaq/11 coordinately activate RhoA and stress fiber formation following receptor stimulation. 
  • beta-Arrestin-mediated ADP-ribosylation factor 6 activation and beta 2-adrenergic receptor endocytosis. 
  • beta-arrestin1 interacts with the catalytic domain of the tyrosine kinase c-SRC. Role of beta-arrestin1-dependent targeting of c-SRC in receptor endocytosis. 
  • beta-arrestins regulate mitogenic signaling and clathrin-mediated endocytosis of the insulin-like growth factor I receptor. 
  • beta-arrestins: traffic cops of cell signaling. 
  • p38 signaling and receptor recycling events in a microfluidic endothelial cell adhesion assay. 
• 

  Keywords of People

  • Bejsovec, Amy, Associate Professor of Biology, Biology
  • Bennett, Vann, George Barth Geller Distinguished Professor of Molecular Biology, Duke Cancer Institute
  • Cianciolo, George James, Associate Professor Emeritus of Pathology, Pathology
  • Krangel, Michael S., George Barth Geller Distinguished Professor of Immunology, Integrative Immunobiology
  • McCall, Shannon Jones, Associate Professor of Pathology, Pathology
  • Soderling, Scott Haydn, George Barth Geller Distinguished Professor of Molecular Biology, Cell Biology