Endometrium

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  Subject Areas on Research

  • 17Beta-estradiol suppresses TLR3-induced cytokine and chemokine production in endometrial epithelial cells. 
  • A diagnostically useful histopathologic feature of endometrial polyp: the long axis of endometrial glands arranged parallel to surface epithelium. 
  • A double-blind randomized study on the effects of red clover isoflavones on the endometrium. 
  • A novel human endometrial epithelial cell line for modeling gynecological diseases and for drug screening. 
  • A primer of endometrial cytology with histological correlation. 
  • A review of endometrium and implantation. 
  • ARID1A and PGR proteins interact in the endometrium and reveal a positive correlation in endometriosis. 
  • Aberrant activation of signal transducer and activator of transcription-3 (STAT3) signaling in endometriosis. 
  • Absence of secretory endometrium after false-positive home urine luteinizing hormone testing. 
  • Abundance and Localization of Progesterone Receptor Isoforms in Endometrium in Women With and Without Endometriosis and in Peritoneal and Ovarian Endometriotic Implants. 
  • Adrenomedullin expression in rat uterus is correlated with plasma estradiol. 
  • Adrenomedullin improves fertility and promotes pinopodes and cell junctions in the peri-implantation endometrium. 
  • Altered expression of microRNA-451 in eutopic endometrium of baboons (Papio anubis) with endometriosis. 
  • Androgens and endometrium: new lessons from the corpus luteum via the adrenal cortex? 
  • Association between endometriosis and gynecological cancers: a critical review of the literature. 
  • Basolateral secretions of human endometrial epithelial organoids impact stromal cell decidualization. 
  • Bioinformatic jujutsu to defeat an endometrial transcriptomic foe. 
  • COUP-TFII regulates human endometrial stromal genes involved in inflammation. 
  • CRISPLD2 is a target of progesterone receptor and its expression is decreased in women with endometriosis. 
  • Cell-autonomous activation of the PI3-kinase pathway initiates endometrial cancer from adult uterine epithelium. 
  • Characterization of GAB1 expression over the menstrual cycle in women with and without polycystic ovarian syndrome provides a new insight into its pathophysiology. 
  • Characterization of the tissue regression process in the uterus of older mice as apoptotic by the presence of Tp30, an isoform of terminin. 
  • Cocaine blocks extraneuronal uptake of norepinephrine by the pregnant human uterus. 
  • Complex hyperplasia with and without atypia: clinical outcomes and implications of progestin therapy. 
  • Complexity in endometrial estradiol signaling. 
  • Controlled preparation of the endometrium with exogenous steroids for the transfer of frozen-thawed pre-embryos in patients with anovulatory or irregular cycles. 
  • Cyclic regulation of T-Bet and GATA-3 in human endometrium. 
  • Cyclic regulation of transcription factor C/EBP beta in human endometrium. 
  • Decreased Notch pathway signaling in the endometrium of women with endometriosis impairs decidualization. 
  • Decreased epithelial progesterone receptor A at the window of receptivity is required for preparation of the endometrium for embryo attachment. 
  • Defining recurrent implantation failure: a profusion of confusion or simply an illusion? 
  • Diagnostic methods to determine microbiology of postpartum endometritis in South Asia: laboratory methods protocol used in the Postpartum Sepsis Study: a prospective cohort study. 
  • Differential Expression of KRAS and SIRT1 in Ovarian Cancers with and Without Endometriosis. 
  • Differential molecular mechanism of the estrogen action that regulates lactoferrin gene in human and mouse. 
  • Direct regulation of beta3-integrin subunit gene expression by HOXA10 in endometrial cells. 
  • Early Endometriosis in Females Is Directed by Immune-Mediated Estrogen Receptor α and IL-6 Cross-Talk. 
  • Effect of randomized serum progesterone concentration on secretory endometrial histologic development and gene expression. 
  • Effects of diazoxide and beta adrenergic drugs on spontaneous and induced uterine activity in the pregnant baboon. 
  • Effects of histone methyltransferase inhibition in endometriosis. 
  • Effects of intranasal administration of norethisterone on folliculogenesis, cervical mucus, vaginal cytology, endometrial morphology and reproductive-endocrine profile in women. 
  • Effects of variations in serum estradiol concentrations on secretory endometrial development and function in experimentally induced cycles in normal women. 
  • Elevated levels of adrenomedullin in eutopic endometrium and plasma from women with endometriosis. 
  • Emerging roles for lysophospholipid mediators in pregnancy. 
  • Endocannabinoid regulation in human endometrium across the menstrual cycle. 
  • Endometrial BCL6 Overexpression in Eutopic Endometrium of Women With Endometriosis. 
  • Endometrial CXCL13 expression is cycle regulated in humans and aberrantly expressed in humans and Rhesus macaques with endometriosis. 
  • Endometrial dating--still room for controversy. 
  • Endometrial development and function in experimentally induced luteal phase deficiency. 
  • Endometrial epithelial ARID1A is critical for uterine gland function in early pregnancy establishment. 
  • Endometrial receptivities after leuprolide suppression and gonadotropin stimulation: histology, steroid receptor concentrations, and implantation rates. 
  • Endometrial receptivity and implantation require uterine BMP signaling through an ACVR2A-SMAD1/SMAD5 axis. 
  • Endometrial receptivity and intrauterine adhesive disease. 
  • Endometrial receptivity: lessons from systems biology and candidate gene studies of endometriosis. 
  • Endomyometriosis ("Uterus-like mass") in an XY Male: Case Report With Molecular Confirmation and Literature Review. 
  • Enterococci in post-cesarean endometritis. 
  • Estradiol regulates MICA expression in human endometrial cells. 
  • Estrogen production and metabolism in endometriosis. 
  • Evaluation of danazol as an oral contraceptive. 
  • Evaluation of endometrial receptivity and implantation failure. 
  • Evaluation, validation and refinement of noninvasive diagnostic biomarkers for endometriosis (ENDOmarker): A protocol to phenotype bio-specimens for discovery and validation. 
  • Evidence of juxtacrine signaling for transforming growth factor alpha in human endometrium. 
  • Expression of Toll-like receptors in human endometrial epithelial cells and cell lines. 
  • Expression of the transmembrane mucins, MUC1, MUC4 and MUC16, in normal endometrium and in endometriosis. 
  • Extracellular vesicles from endometriosis patients are characterized by a unique miRNA-lncRNA signature. 
  • FOXO1 regulates uterine epithelial integrity and progesterone receptor expression critical for embryo implantation. 
  • Female steroid hormones use signal transducers and activators of transcription protein-mediated pathways to modulate the expression of T-bet in epithelial cells: a mechanism for local immune regulation in the human reproductive tract. 
  • G protein-coupled estrogen receptor (GPER) expression in normal and abnormal endometrium. 
  • GOG 8020/210: Risk stratification of lymph node metastasis, disease progression and survival using single nucleotide polymorphisms in endometrial cancer: An NRG oncology/gynecologic oncology group study. 
  • Genetic and epigenetic changes in the eutopic endometrium of women with endometriosis: association with decreased endometrial αvβ3 integrin expression. 
  • High throughput, cell type-specific analysis of key proteins in human endometrial biopsies of women from fertile and infertile couples. 
  • Histological dating of timed endometrial biopsy tissue is not related to fertility status. 
  • Histopathologic distinctions in the relationship of estrogens and endometrial cancer. 
  • Homeostasis imbalance in the endometrium of women with implantation defects: the role of estrogen and progesterone. 
  • Hormonal and Growth Regulation of Epithelial and Stromal Cells From the Normal and Malignant Endometrium by Pigment Epithelium-Derived Factor. 
  • Hormone control and expression of androgen receptor coregulator MAGE-11 in human endometrium during the window of receptivity to embryo implantation. 
  • Human Endometrial Transcriptome and Progesterone Receptor Cistrome Reveal Important Pathways and Epithelial Regulators. 
  • Human endometrial epithelial cells cyclically express Toll-like receptor 3 (TLR3) and exhibit TLR3-dependent responses to dsRNA. 
  • Human endometrial transforming growth factor-alpha: a transmembrane, surface epithelial protein that transiently disappears during the midsecretory phase of the menstrual cycle. 
  • Hyaluronic Acid Hydrogel Integrated with Mesenchymal Stem Cell-Secretome to Treat Endometrial Injury in a Rat Model of Asherman's Syndrome. 
  • Hysteroscopic Endometrial Polypectomy with Manual Vacuum Aspiration Compared to Mechanical Morcellation. 
  • IL-17A Contributes to the Pathogenesis of Endometriosis by Triggering Proinflammatory Cytokines and Angiogenic Growth Factors. 
  • Immune-inflammation gene signatures in endometriosis patients. 
  • Immunologic, virologic, and pharmacologic characterization of the female upper genital tract in HIV-infected women. 
  • In vitro models of the human endometrium: evolution and application for women's health. 
  • In vivo and in vitro evidence suggest that HB-EGF regulates endometrial expression of human decay-accelerating factor. 
  • Incidence and clinical significance of morphologically benign-appearing endometrial cells in patients age 40 years or older: the impact of the 2001 Bethesda System. 
  • Induction of maternal tolerance to fetal alloantigens by RANTES production. 
  • Integrative analysis of the forkhead box A2 (FOXA2) cistrome for the human endometrium. 
  • Integrins and other cell adhesion molecules in endometrium and endometriosis. 
  • Interleukin-1beta elevates cyclooxygenase-2 protein level and enzyme activity via increasing its mRNA stability in human endometrial stromal cells: an effect mediated by extracellularly regulated kinases 1 and 2. 
  • Interleukin-33 modulates inflammation in endometriosis. 
  • Interobserver and intraobserver variability in the histological dating of the endometrium in fertile and infertile women. 
  • KRAS Activation and over-expression of SIRT1/BCL6 Contributes to the Pathogenesis of Endometriosis and Progesterone Resistance. 
  • Lactoferrin expression in the mouse reproductive tract during the natural estrous cycle: correlation with circulating estradiol and progesterone. 
  • Lactoferrin gene expression is estrogen responsive in human and rhesus monkey endometrium. 
  • Large, Non-Cavity Distorting Intramural Leiomyomas Decrease Leukemia Inhibitory Factor in the Secretory Phase Endometrium. 
  • Localization of tenascin in uterine sarcomas and partially transformed endometrial stromal cells. 
  • Loss of HDAC3 results in nonreceptive endometrium and female infertility. 
  • Loss of MIG-6 results in endometrial progesterone resistance via ERBB2. 
  • Malignant transformation of the human endometrium is associated with overexpression of lactoferrin messenger RNA and protein. 
  • Mechanical signaling in reproductive tissues: mechanisms and importance. 
  • Menstrual cyclic change of metastin/GPR54 in endometrium. 
  • Metastatic malignant melanoma in an endometrial polyp. 
  • Microarray analysis reveals distinct gene expression profiles among different histologic types of endometrial cancer. 
  • Modulation of implantation-associated integrin expression but not uteroglobin by steroid hormones in an endometrial cell line. 
  • Msx Homeobox Genes Act Downstream of BMP2 to Regulate Endometrial Decidualization in Mice and in Humans. 
  • Neutrophil recruitment and function in endometriosis patients and a syngeneic murine model. 
  • Nuclear pore complex proteins mark the implantation window in human endometrium. 
  • Oestrogen and progesterone action on endometrium: a translational approach to understanding endometrial receptivity. 
  • Overexpression of Four Joint Box-1 Protein (FJX1) in Eutopic Endometrium From Women With Endometriosis. 
  • Parallel Expression of Enzyme Inhibitors of CD8T Cell Activity in Tumor Microenvironments and Secretory Endometrium. 
  • Pathogenesis of endometriosis. 
  • Patterns of gene expression in different histotypes of epithelial ovarian cancer correlate with those in normal fallopian tube, endometrium, and colon. 
  • Patterns of use and outcomes of sentinel lymph node mapping for patients with high-grade endometrial cancer. 
  • Pelvic inflammatory disease. 
  • Pinopodes: Recent advancements, current perspectives, and future directions. 
  • Podocalyxin is a key negative regulator of human endometrial epithelial receptivity for embryo implantation. 
  • Poor Endometrial Proliferation After Clomiphene is Associated With Altered Estrogen Action. 
  • Porcine necrotizing staphylococcal endometritis. 
  • Preservation of the endometrial enhancement after magnetic resonance imaging-guided high-intensity focused ultrasound ablation of submucosal uterine fibroids. 
  • Primate-specific melanoma antigen-A11 regulates isoform-specific human progesterone receptor-B transactivation. 
  • Progesterone Resistance in Endometriosis Is Modulated by the Altered Expression of MicroRNA-29c and FKBP4. 
  • Progesterone Signaling in Endometrial Epithelial Organoids. 
  • Progesterone function in human endometrium: clinical perspectives. 
  • Progesterone resistance in PCOS endometrium: a microarray analysis in clomiphene citrate-treated and artificial menstrual cycles. 
  • Prospective assessment of midsecretory endometrial leukemia inhibitor factor expression versus ανβ3 testing in women with unexplained infertility. 
  • Protein Inhibitor of Activated STAT3 (PIAS3) Is Down-Regulated in Eutopic Endometrium of Women with Endometriosis. 
  • Proteomic analysis of endometrium from fertile and infertile patients suggests a role for apolipoprotein A-I in embryo implantation failure and endometriosis. 
  • Proteomic analysis of the luteal endometrial secretome. 
  • RBPJ mediates uterine repair in the mouse and is reduced in women with recurrent pregnancy loss. 
  • Randomized Phase II Trial of Carboplatin-Paclitaxel Compared with Carboplatin-Paclitaxel-Trastuzumab in Advanced (Stage III-IV) or Recurrent Uterine Serous Carcinomas that Overexpress Her2/Neu (NCT01367002): Updated Overall Survival Analysis. 
  • Reactivity of epidermal growth factor receptor monoclonal antibodies with human uterine tissues. 
  • Regulated expression of heparin-binding EGF-like growth factor (HB-EGF) in the human endometrium: a potential paracrine role during implantation. 
  • Relationship between minimally invasive hysterectomy, pelvic cytology, and lymph vascular space invasion: a single institution study of 458 patients. 
  • Resveratrol and endometrium: a closer look at an active ingredient of red wine using in vivo and in vitro models. 
  • Role of SIRT1 and Progesterone Resistance in Normal and Abnormal Endometrium. 
  • SIRT1 plays an important role in implantation and decidualization during mouse early pregnancy. 
  • SOX17 regulates uterine epithelial-stromal cross-talk acting via a distal enhancer upstream of Ihh. 
  • Safety and efficacy of the selective progesterone receptor modulator asoprisnil for heavy menstrual bleeding with uterine fibroids: pooled analysis of two 12-month, placebo-controlled, randomized trials. 
  • Self-renewing endometrial epithelial organoids of the human uterus. 
  • Should we stop offering endometrial scratching prior to in vitro fertilization? 
  • Sonographic appearance of the endometrium: the predictive value for the outcome of in-vitro fertilization in stimulated cycles. 
  • Systematic review highlights difficulty interpreting diverse clinical outcomes in abnormal uterine bleeding trials. 
  • The Estrogen Receptor α Cistrome in Human Endometrium and Epithelial Organoids. 
  • The endometria of women with endometriosis exhibit dysfunctional expression of complement regulatory proteins during the mid secretory phase. 
  • The reproducibility of endometrial volume acquisition and measurement with the VOCAL-imaging program. 
  • The two FIGO systems for normal and abnormal uterine bleeding symptoms and classification of causes of abnormal uterine bleeding in the reproductive years: 2018 revisions. 
  • Transfer of cryopreserved-thawed pre-embryos in a cycle using exogenous steroids without prior gonadotrophin-releasing hormone agonist suppression yields favourable pregnancy results. 
  • Ultrasonographic appearance of the endometrium in natural and stimulated in-vitro fertilization cycles and its correlation with outcome. 
  • Ultrasound of the postpartum uterus. Prediction of retained placental tissue. 
  • Up-regulation of cyclooxygenase-2 expression and prostaglandin synthesis in endometrial stromal cells by malignant endometrial epithelial cells. A paracrine effect mediated by prostaglandin E2 and nuclear factor-kappa B. 
  • Uterine Neoplasms. Clinical Practice Guidelines in Oncology. 
  • Vaginal administration of low-dose conjugated estrogens: systemic absorption and effects on the endometrium. 
  • WNT4 acts downstream of BMP2 and functions via β-catenin signaling pathway to regulate human endometrial stromal cell differentiation. 
  • WT1 and DAX-1 inhibit aromatase P450 expression in human endometrial and endometriotic stromal cells. 
  • What exactly is endometrial receptivity? 
  • cAMP-Response Element-Binding 3-Like Protein 1 (CREB3L1) is Required for Decidualization and its Expression is Decreased in Women with Endometriosis. 
  • p53lyn and p56lyn: a new signaling pathway in human endometrium and endometrial adenocarcinomas. 
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  Keywords of People

  • Berchuck, Andrew, James M. Ingram Distinguished Professor of Gynecologic Oncology, Obstetrics and Gynecology, Gynecologic Oncology