Endonucleases

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  Subject Areas on Research

  • A circular trans-acting hepatitis delta virus ribozyme. 
  • A nuclease-resistant RNA aptamer specifically inhibits angiopoietin-1-mediated Tie2 activation and function. 
  • Association and interactions between DNA repair gene polymorphisms and adult glioma. 
  • Association between the ERCC5 Asp1104His polymorphism and cancer risk: a meta-analysis. 
  • Beta-thalassemia resulting from a single nucleotide substitution in an acceptor splice site. 
  • Cas9 loosens its grip on off-target sites. 
  • Characterization of reaction intermediates of human excision repair nuclease. 
  • Chromosome aberrations resulting from double-strand DNA breaks at a naturally occurring yeast fragile site composed of inverted ty elements are independent of Mre11p and Sae2p. 
  • Clinical and Genetic Risk Prediction of Subsequent CNS Tumors in Survivors of Childhood Cancer: A Report From the COG ALTE03N1 Study. 
  • Clinical application of whole-genome sequencing in patients with primary immunodeficiency. 
  • Correction of dystrophin expression in cells from Duchenne muscular dystrophy patients through genomic excision of exon 51 by zinc finger nucleases. 
  • Correlation of DNA fragmentation and chromatin condensation in apoptotic nuclei of the Ser 6 mouse retina. 
  • Cyanobacterial ribosomal RNA genes with multiple, endonuclease-encoding group I introns 
  • DNA polymerase zeta introduces multiple mutations when bypassing spontaneous DNA damage in Saccharomyces cerevisiae. 
  • DNA repair gene ERCC1 and ERCC2/XPD polymorphisms and risk of squamous cell carcinoma of the head and neck. 
  • Diagnosis of 22q11.2 deletion syndrome and artemis deficiency in two children with T-B-NK+ immunodeficiency. 
  • Differential staining of actin in metaphase spindles with 7-nitrobenz-2-oxa-1,3-diazole-phallacidin and fluorescent DNase: is actin involved in chromosomal movement? 
  • Direct carrier testing in 14 families with haemophilia B. 
  • ERCC1 and ERCC2 polymorphisms predict clinical outcomes of oxaliplatin-based chemotherapies in gastric and colorectal cancer: a systemic review and meta-analysis. 
  • ERCC1 and ERCC2 variants predict survival in gastric cancer patients. 
  • ERCC1 protein expression is associated with differential survival in oropharyngeal head and neck squamous cell carcinoma. 
  • EcoRI endonuclease. Physical and catalytic properties of the homogenous enzyme. 
  • Effects of hexavalent chromium on the survival and cell cycle distribution of DNA repair-deficient S. cerevisiae. 
  • Efficient generation of targeted and controlled mutational events in porcine cells using nuclease-directed homologous recombination. 
  • EndoU is a novel regulator of AICD during peripheral B cell selection. 
  • Endonuclease-independent DNA mismatch repair processes on the lagging strand. 
  • Evidence that non-caspase proteases are required for chromatin degradation during apoptosis. 
  • Evolution of Pleopsidium (lichenized Ascomycota) S943 group I introns and the phylogeography of an intron-encoded putative homing endonuclease. 
  • Expression of nucleotide excision repair genes and the risk for squamous cell carcinoma of the head and neck. 
  • Functional genetic variants of XRCC4 and ERCC1 predict survival of gastric cancer patients treated with chemotherapy by regulating the gene expression. 
  • Genetic polymorphisms of selected DNA repair genes, estrogen and progesterone receptor status, and breast cancer risk. 
  • Genetic variants in ERCC1 and XPC predict survival outcome of non-small cell lung cancer patients treated with platinum-based therapy. 
  • Genome-editing Technologies for Gene and Cell Therapy. 
  • Genotypes and haplotypes of ERCC1 and ERCC2/XPD genes predict levels of benzo[a]pyrene diol epoxide-induced DNA adducts in cultured primary lymphocytes from healthy individuals: a genotype-phenotype correlation analysis. 
  • High gene expression of TS1, GSTP1, and ERCC1 are risk factors for survival in patients treated with trimodality therapy for esophageal cancer. 
  • Highly active zinc-finger nucleases by extended modular assembly. 
  • Human MutLγ, the MLH1-MLH3 heterodimer, is an endonuclease that promotes DNA expansion. 
  • Improving the clinical risk score: an analysis of molecular biomarkers in the era of modern chemotherapy for resectable hepatic colorectal cancer metastases. 
  • In Vivo Zinc Finger Nuclease-mediated Targeted Integration of a Glucose-6-phosphatase Transgene Promotes Survival in Mice With Glycogen Storage Disease Type IA. 
  • In vitro maturation of circular bacteriophage P2 DNA. Purification of ter components and characterization of the reaction. 
  • In vivo activity of nuclease-resistant siRNAs. 
  • In vivo repair of alkylating and oxidative DNA damage in the mitochondrial and nuclear genomes of wild-type and glycosylase-deficient Caenorhabditis elegans 
  • Inactivation of the human papillomavirus E6 or E7 gene in cervical carcinoma cells by using a bacterial CRISPR/Cas RNA-guided endonuclease. 
  • Interplay between structure-specific endonucleases for crossover control during Caenorhabditis elegans meiosis. 
  • Interplay of catalysis, fidelity, threading, and processivity in the exo- and endonucleolytic reactions of human exonuclease I. 
  • Isolation and characterization of the Escherichia coli mutH gene product. 
  • Machine Learning Approach to Classify Cardiovascular Disease in Patients With Nonalcoholic Fatty Liver Disease in the UK Biobank Cohort. 
  • Meiotic recombination involving heterozygous large insertions in Saccharomyces cerevisiae: formation and repair of large, unpaired DNA loops. 
  • Mre11-Sae2 and RPA Collaborate to Prevent Palindromic Gene Amplification. 
  • Multiple DNA repair mechanisms and alkylator resistance in the human medulloblastoma cell line D-283 Med (4-HCR). 
  • No evidence of an association of ERCC1 and ERCC2 polymorphisms with clinical outcomes of platinum-based chemotherapies in non-small cell lung cancer: a meta-analysis. 
  • Overlapping specificities of base excision repair, nucleotide excision repair, recombination, and translesion synthesis pathways for DNA base damage in Saccharomyces cerevisiae. 
  • PCNA function in the activation and strand direction of MutLα endonuclease in mismatch repair. 
  • PMS2 endonuclease activity has distinct biological functions and is essential for genome maintenance. 
  • Polymorphisms in ERCC1 and XPF genes and risk of gastric cancer in an eastern Chinese population. 
  • Polymorphisms in the DNA repair genes XPC, XPD, and XPG and risk of cutaneous melanoma: a case-control analysis. 
  • Polymorphisms in the ERCC5 gene and risk of esophageal squamous cell carcinoma (ESCC) in Eastern Chinese populations. 
  • Polymorphisms in the XPG gene and risk of gastric cancer in Chinese populations. 
  • Polymorphisms of XPG/ERCC5 and risk of squamous cell carcinoma of the head and neck. 
  • Polymorphisms of nucleotide excision repair genes predict melanoma survival. 
  • Potentially functional variants in the core nucleotide excision repair genes predict survival in Japanese gastric cancer patients. 
  • Prognostic significance of mucin and p53 expression in stage IB non-small cell lung cancer: a laboratory companion study to CALGB 9633. 
  • RGEN Editing of RNA and DNA: The Long and Winding Road from Catalytic RNAs to CRISPR to the Clinic. 
  • RNA-guided transcriptional silencing in vivo with S. aureus CRISPR-Cas9 repressors. 
  • Reaction mechanism of human DNA repair excision nuclease. 
  • Reading frame correction by targeted genome editing restores dystrophin expression in cells from Duchenne muscular dystrophy patients. 
  • Recognition sequence of the dam methylase of Escherichia coli K12 and mode of cleavage of Dpn I endonuclease. 
  • Recombination between homologous chromosomes induced by unrepaired UV-generated DNA damage requires Mus81p and is suppressed by Mms2p. 
  • Recombinational Repair of Nuclease-Generated Mitotic Double-Strand Breaks with Different End Structures in Yeast. 
  • Reduced expression levels of nucleotide excision repair genes in lung cancer: a case-control analysis. 
  • RelB cellular regulation and transcriptional activity are regulated by p100. 
  • Repair of DNA loops involves DNA-mismatch and nucleotide-excision repair proteins. 
  • Resveratrol prevents protein nitration and release of endonucleases from mitochondria during acetaminophen hepatotoxicity. 
  • Saccharomyces cerevisiae MutLalpha is a mismatch repair endonuclease. 
  • Sequence variations in DNA repair gene XPC is associated with lung cancer risk in a Chinese population: a case-control study. 
  • Some properties of a DNA-unwinding protein unique to lymphocytes from chronic lymphocytic leukemia. 
  • Structure of the endonuclease domain of MutL: unlicensed to cut. 
  • Structure of the eukaryotic transcription apparatus: features of the gene for the largest subunit of Drosophila RNA polymerase II. 
  • Structures and mechanisms of DNA restriction and modification enzymes. 
  • Structures of human exonuclease 1 DNA complexes suggest a unified mechanism for nuclease family. 
  • Tagging single nucleotide polymorphisms in excision repair cross-complementing group 1 (ERCC1) and risk of primary lung cancer in a Chinese population. 
  • Temporal and tissue-specific expression of distinct retrovirus-like (VL30) elements during mouse development. 
  • The evolution of homing endonuclease genes and group I introns in nuclear rDNA. 
  • The next generation of CRISPR-Cas technologies and applications. 
  • Two restriction-like enzymes from Xanthomonas malvacearum. 
  • Variants in nucleotide excision repair core genes and susceptibility to recurrence of squamous cell carcinoma of the oropharynx. 
  • Wogonin and fisetin induce apoptosis in human promyeloleukemic cells, accompanied by a decrease of reactive oxygen species, and activation of caspase 3 and Ca(2+)-dependent endonuclease. 
  • Yeast base excision repair: interconnections and networks. 
  • α-synucleinopathy exerts sex-dimorphic effects on the multipurpose DNA repair/redox protein APE1 in mice and humans.