Endoplasmic Reticulum

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  Subject Areas on Research

  • A Circle RNA Regulatory Axis Promotes Lung Squamous Metastasis via CDR1-Mediated Regulation of Golgi Trafficking. 
  • A critical role of eEF-2K in mediating autophagy in response to multiple cellular stresses. 
  • A link between endoplasmic reticulum stress-induced β-cell apoptosis and the group VIA Ca2+-independent phospholipase A2 (iPLA2β). 
  • A mathematical model for persistent post-CSD vasoconstriction. 
  • A mathematical model quantifying GnRH-induced LH secretion from gonadotropes. 
  • A novel function of VCP (valosin-containing protein; p97) in the control of N-glycosylation of proteins in the endoplasmic reticulum. 
  • A pharmacoproteomic approach implicates eukaryotic elongation factor 2 kinase in ER stress-induced cell death. 
  • A platform for compartmentalized protein synthesis: protein translation and translocation in the ER. 
  • A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress. 
  • A signature in HIV-1 envelope leader peptide associated with transition from acute to chronic infection impacts envelope processing and infectivity. 
  • AAV exploits subcellular stress associated with inflammation, endoplasmic reticulum expansion, and misfolded proteins in models of cystic fibrosis. 
  • Acetaminophen toxicity in cultured trout liver cells. I. Morphological alterations and effects on cytochrome P450 1A1. 
  • Acetaminophen toxicity in cultured trout liver cells. II. Maintenance of cytochrome P450 1A1. 
  • Alveolar type II cell responses to chronic inhalation of chrysotile asbestos in rats. 
  • Amino acid permeases require COPII components and the ER resident membrane protein Shr3p for packaging into transport vesicles in vitro. 
  • Analysis of mRNA partitioning between the cytosol and endoplasmic reticulum compartments of mammalian cells. 
  • Analyzing mRNA localization to the endoplasmic reticulum via cell fractionation. 
  • Androgen-induced expression of endoplasmic reticulum (ER) stress response genes in prostate cancer cells. 
  • Argyrosis of the lacrimal sac. 
  • Association with endoplasmic reticulum promotes proteasomal degradation of GADD34 protein. 
  • Autophagy regulates endoplasmic reticulum homeostasis and calcium mobilization in T lymphocytes. 
  • BPIFB3 Regulates Endoplasmic Reticulum Morphology To Facilitate Flavivirus Replication. 
  • BPIFB3 interacts with ARFGAP1 and TMED9 to regulate non-canonical autophagy and RNA virus infection. 
  • BPIFB3 regulates autophagy and coxsackievirus B replication through a noncanonical pathway independent of the core initiation machinery. 
  • BPIFB6 Regulates Secretory Pathway Trafficking and Enterovirus Replication. 
  • Bcl-2 suppresses sarcoplasmic/endoplasmic reticulum Ca2+-ATPase expression in cystic fibrosis airways: role in oxidant-mediated cell death. 
  • Bi-allelic variants in the ER quality-control mannosidase gene EDEM3 cause a congenital disorder of glycosylation. 
  • Binding of anti-GRP78 autoantibodies to cell surface GRP78 increases tissue factor procoagulant activity via the release of calcium from endoplasmic reticulum stores. 
  • Biochemical, cell biological and immunological issues surrounding the endoplasmic reticulum chaperone GRP94/gp96. 
  • Biology of hepatocellular neoplasia in the mouse. III. Electron microscopy of safrole-induced hepatocellular adenomas and hepatocellular carcinomas. 
  • Biomedicine. Insulin resistance takes a trip through the ER. 
  • Bortezomib inhibits PKR-like endoplasmic reticulum (ER) kinase and induces apoptosis via ER stress in human pancreatic cancer cells. 
  • Bortezomib sensitizes pancreatic cancer cells to endoplasmic reticulum stress-mediated apoptosis. 
  • CHOP mediates endoplasmic reticulum stress-induced apoptosis in Gimap5-deficient T cells. 
  • CLN3p impacts galactosylceramide transport, raft morphology, and lipid content. 
  • COPII and secretory cargo capture into transport vesicles. 
  • COPII-cargo interactions direct protein sorting into ER-derived transport vesicles. 
  • Calcineurin colocalizes with P-bodies and stress granules during thermal stress in Cryptococcus neoformans. 
  • Calcium signals and calpain-dependent necrosis are essential for release of coxsackievirus B from polarized intestinal epithelial cells. 
  • Canalicular reticulum in vestibular hair cells. 
  • Catch me if you can: the link between autophagy and viruses. 
  • Cell biology: How to combat stress. 
  • Cellular response to endoplasmic reticulum stress: a matter of life or death. 
  • Chaperone-mediated cross-priming: a hitchhiker's guide to vesicle transport (review). 
  • Characterization of kinectin, a kinesin-binding protein: primary sequence and N-terminal topogenic signal analysis. 
  • Characterization of three Arabidopsis homologs of human RING membrane anchor E3 ubiquitin ligase. 
  • Cholesterol-induced macrophage apoptosis requires ER stress pathways and engagement of the type A scavenger receptor. 
  • Coat proteins and selective protein packaging into transport vesicles. 
  • Comparison of acute response to polychlorinated biphenyl in liver of rat and channel catfish: a biochemical and morphological study. 
  • Control of antiviral innate immune response by protein geranylgeranylation. 
  • Control of cellular GADD34 levels by the 26S proteasome. 
  • Control of innate immune signaling and membrane targeting by the Hepatitis C virus NS3/4A protease are governed by the NS3 helix α0. 
  • Coupling endoplasmic reticulum stress to cell death program in isolated human pancreatic islets: effects of gene transfer of Bcl-2. 
  • Cytotoxicity phase of diethylnitrosamine-induced hepatic neoplasia in medaka. 
  • De novo translation initiation on membrane-bound ribosomes as a mechanism for localization of cytosolic protein mRNAs to the endoplasmic reticulum. 
  • Dengue Virus Selectively Annexes Endoplasmic Reticulum-Associated Translation Machinery as a Strategy for Co-opting Host Cell Protein Synthesis. 
  • Dengue and Zika viruses subvert reticulophagy by NS2B3-mediated cleavage of FAM134B. 
  • Dengue virus and autophagy. 
  • Destabilization of the VCP-Ufd1-Npl4 complex is associated with decreased levels of ERAD substrates. 
  • Developing seeds of Arabidopsis store different minerals in two types of vacuoles and in the endoplasmic reticulum. 
  • Developmental regulation of alpha beta T cell antigen receptor expression results from differential stability of nascent TCR alpha proteins within the endoplasmic reticulum of immature and mature T cells. 
  • Differential maturation and subcellular localization of severe acute respiratory syndrome coronavirus surface proteins S, M and E. 
  • Disorders of cell volume regulation. I. Effects of inhibition of plasma membrane adenosine triphosphatase with ouabain. 
  • Disruption of sarcoendoplasmic reticulum calcium ATPase function in Drosophila leads to cardiac dysfunction. 
  • Distinct patterns of glycosylation of colligin, a collagen-binding glycoprotein, and SPARC (osteonectin), a secreted Ca2+-binding glycoprotein. Evidence for the localisation of colligin in the endoplasmic reticulum. 
  • Divergent regulation of protein synthesis in the cytosol and endoplasmic reticulum compartments of mammalian cells. 
  • Diversity and selectivity in mRNA translation on the endoplasmic reticulum. 
  • Domain 3 of hepatitis C virus core protein is sufficient for intracellular lipid accumulation. 
  • Dynamic movements of organelles containing Niemann-Pick C1 protein: NPC1 involvement in late endocytic events. 
  • Dynamic regulation of sarcoplasmic reticulum Ca(2+) stores by stromal interaction molecule 1 and sarcolipin during muscle differentiation. 
  • ER stress as a trigger for β-cell dysfunction and autoimmunity in type 1 diabetes. 
  • ER stress modulates cellular metabolism. 
  • ERAAP synergizes with MHC class I molecules to make the final cut in the antigenic peptide precursors in the endoplasmic reticulum. 
  • Eca1, a sarcoplasmic/endoplasmic reticulum Ca2+-ATPase, is involved in stress tolerance and virulence in Cryptococcus neoformans. 
  • Effect of lysine and threonine deficient and supplement rice diets on lipids of hepatic smooth and rough endoplasmic reticulum of rats. 
  • Effects of vitamin A and phenobarbital on liver endoplasmic reticulum of rats. 
  • Electron microscopy of young Candida albicans chlamydospores. 
  • Endoplasmic reticulum chaperone GRP94 subunit assembly is regulated through a defined oligomerization domain. 
  • Endoplasmic reticulum sorting and kinesin-1 command the targeting of axonal GABAB receptors. 
  • Endoplasmic reticulum stress, hepatocyte CD1d and NKT cell abnormalities in murine fatty livers. 
  • Endoplasmic reticulum stress. 
  • Endoplasmic reticulum-bound ribosomes reside in stable association with the translocon following termination of protein synthesis. 
  • Epithelial-to-mesenchymal transition activates PERK-eIF2α and sensitizes cells to endoplasmic reticulum stress. 
  • Erg6 affects membrane composition and virulence of the human fungal pathogen Cryptococcus neoformans. 
  • Erythrocyte phagocytosis in the human trabecular meshwork. 
  • Evidence for Compartmentalized Axonal Mitochondrial Biogenesis: Mitochondrial DNA Replication Increases in Distal Axons As an Early Response to Parkinson's Disease-Relevant Stress. 
  • Evidence for nutrient-dependent regulation of the COPII coat by O-GlcNAcylation. 
  • Expression of functional bacterial undecaprenyl pyrophosphate synthase in the yeast rer2{Delta} mutant and CHO cells. 
  • FIT2 is an acyl-coenzyme A diphosphatase crucial for endoplasmic reticulum homeostasis. 
  • Fine structure of a radiation-induced osteogenic sarcoma. 
  • Fitm2 is required for ER homeostasis and normal function of murine liver. 
  • Functional regulation of Wnt protein through post-translational modifications. 
  • GRP78: a chaperone with diverse roles beyond the endoplasmic reticulum. 
  • GTP-mediated Ca2+ release in rough endoplasmic reticulum. Correlation with a GTP-sensitive increase in membrane permeability. 
  • Gibberellin signaling: biosynthesis, catabolism, and response pathways. 
  • Glioblastoma proto-oncogene SEC61gamma is required for tumor cell survival and response to endoplasmic reticulum stress. 
  • Glutamate excitotoxicity in neurons triggers mitochondrial and endoplasmic reticulum accumulation of Parkin, and, in the presence of N-acetyl cysteine, mitophagy. 
  • Growth arrest and DNA damage-inducible protein GADD34 targets protein phosphatase 1 alpha to the endoplasmic reticulum and promotes dephosphorylation of the alpha subunit of eukaryotic translation initiation factor 2. 
  • Hepatic GALE Regulates Whole-Body Glucose Homeostasis by Modulating Tff3 Expression. 
  • Hepatic cellular distribution of cytochrome P-450 IA1 in rainbow trout (Oncorhynchus mykiss): an immunohisto- and cytochemical study. 
  • Hepatic parenchymal cells in cystic fibrosis: ultrastructural evidence for abnormal intracellular transport. 
  • Herpes simplex virus blocks intracellular transport of HLA-G in placentally derived human cells. 
  • Heterogeneous translational landscape of the endoplasmic reticulum revealed by ribosome proximity labeling and transcriptome analysis. 
  • Hierarchical regulation of mRNA partitioning between the cytoplasm and the endoplasmic reticulum of mammalian cells. 
  • Hsp 70/Hsp 90 organizing protein as a nitrosylation target in cystic fibrosis therapy. 
  • Identification of calcium-modulating cyclophilin ligand (CAML) as transducer of angiotensin II-mediated nuclear factor of activated T cells (NFAT) activation. 
  • Identification of novel quaternary domain interactions in the Hsp90 chaperone, GRP94. 
  • Identification of self-lipids presented by CD1c and CD1d proteins. 
  • Imaging-Based Reporter Systems to Define CVB-Induced Membrane Remodeling in Living Cells. 
  • In situ cryofixation of kidney for electron probe X-ray microanalysis. 
  • In vitro and tissue culture methods for analysis of translation initiation on the endoplasmic reticulum. 
  • Increased production of sonic hedgehog by ballooned hepatocytes. 
  • Induction of protein secretory pathway is required for systemic acquired resistance. 
  • Inositol 1,4,5-trisphosphate receptor localization and stability in neonatal cardiomyocytes requires interaction with ankyrin-B. 
  • Interaction of endoplasmic reticulum chaperone GRP94 with peptide substrates is adenine nucleotide-independent. 
  • Intestinal inflammation requires FOXO3 and prostaglandin E2-dependent lipogenesis and elevated lipid droplets. 
  • Iron metabolism and cell membranes. II. The relationship of ferritin to the cytocavitary network in rat hepatic parenchymal cells. 
  • LOCAL TRANSLATION. Comment on "Principles of ER cotranslational translocation revealed by proximity-specific ribosome profiling". 
  • Lipid rafts function in biosynthetic delivery of proteins to the cell surface in yeast. 
  • Lipid rafts in protein sorting and cell polarity in budding yeast Saccharomyces cerevisiae. 
  • Localization of a baculovirus-induced chitinase in the insect cell endoplasmic reticulum. 
  • Long-Chain Polyprenols Promote Spore Wall Formation in Saccharomyces cerevisiae. 
  • Lumenal proteins of the mammalian endoplasmic reticulum are required to complete protein translocation. 
  • M1 of Murine Gamma-Herpesvirus 68 Induces Endoplasmic Reticulum Chaperone Production. 
  • MAVS Coordination of Antiviral Innate Immunity. 
  • Macrophage deficiency of p38alpha MAPK promotes apoptosis and plaque necrosis in advanced atherosclerotic lesions in mice. 
  • Membrane topology mapping of vitamin K epoxide reductase by in vitro translation/cotranslocation. 
  • Methods to Visualize MAVS Subcellular Localization. 
  • Mitochondrial-associated endoplasmic reticulum membranes (MAM) form innate immune synapses and are targeted by hepatitis C virus. 
  • Modulation of the unfolded protein response in prostate cancer cells by antibody-directed against the carboxyl-terminal domain of GRP78. 
  • Molecular determinants and dynamics of hepatitis C virus secretion. 
  • Mouse liver cell culture. I. Hepatocyte isolation. 
  • Multifunctional roles for the protein translocation machinery in RNA anchoring to the endoplasmic reticulum. 
  • Multiple activities of the plant pathogen type III effector proteins WtsE and AvrE require WxxxE motifs. 
  • Nascent secretory chain binding and translocation are distinct processes: differentiation by chemical alkylation. 
  • Nelfinavir, A lead HIV protease inhibitor, is a broad-spectrum, anticancer agent that induces endoplasmic reticulum stress, autophagy, and apoptosis in vitro and in vivo. 
  • New lessons in the regulation of glucose metabolism taught by the glucose 6-phosphatase system. 
  • Novel type of proliferating lymphoplasmacytoid cell with a characteristic spotted immunofluorescence pattern. 
  • Observations on cell volume, ultrastructure, mitochondrial conformation and vital-dye uptake in Ehrlich ascites tumor cells. Effects of inhibiting energy production and function of the plasma membrane. 
  • Oncoprotein AEG-1 is an endoplasmic reticulum RNA-binding protein whose interactome is enriched in organelle resident protein-encoding mRNAs. 
  • Overexpression of rat long chain acyl-coa synthetase 1 alters fatty acid metabolism in rat primary hepatocytes. 
  • Palmitate-mediated disruption of the endoplasmic reticulum decreases intracellular vesicle motility. 
  • Partitioning and translation of mRNAs encoding soluble proteins on membrane-bound ribosomes. 
  • Pathways for compartmentalizing protein synthesis in eukaryotic cells: the template-partitioning model. 
  • Phosphoenolpyruvate Is a Metabolic Checkpoint of Anti-tumor T Cell Responses. 
  • Primary role for endoplasmic reticulum-bound ribosomes in cellular translation identified by ribosome profiling. 
  • Protein kinase C signaling during T cell activation induces the endoplasmic reticulum stress response. 
  • Protein synthesis inhibitors and the chemical chaperone TMAO reverse endoplasmic reticulum perturbation induced by overexpression of the iodide transporter pendrin. 
  • Protein synthesis. The perks of balancing glucose. 
  • Proteomic analysis of mitochondrial-associated ER membranes (MAM) during RNA virus infection reveals dynamic changes in protein and organelle trafficking. 
  • Pseudomonas aeruginosa vesicles associate with and are internalized by human lung epithelial cells. 
  • Quality Control in Neurons: Mitophagy and Other Selective Autophagy Mechanisms. 
  • Quantitative Proteomics Links the LRRC59 Interactome to mRNA Translation on the ER Membrane. 
  • RAB-10-Dependent Membrane Transport Is Required for Dendrite Arborization. 
  • Re-patterning of skeletal muscle energy metabolism by fat storage-inducing transmembrane protein 2. 
  • Receptor mediated and fluid phase pathways for internalization of the ER Hsp90 chaperone GRP94 in murine macrophages. 
  • Receptor quality control in the endoplasmic reticulum for plant innate immunity. 
  • Recruitment of endoplasmic reticulum-targeted and cytosolic mRNAs into membrane-associated stress granules. 
  • Regulation of ribosome detachment from the mammalian endoplasmic reticulum membrane. 
  • Regulation of the ribosome-membrane junction at early stages of presecretory protein translocation in the mammalian endoplasmic reticulum. 
  • Research Resource: Roles for Calcium/Calmodulin-Dependent Protein Kinase Kinase 2 (CaMKK2) in Systems Metabolism. 
  • Response of bone marrow to MC29 avian leukosis virus in vitro. 
  • Retention of pendrin in the endoplasmic reticulum is a major mechanism for Pendred syndrome. 
  • Ribosome-independent regulation of translocon composition and Sec61alpha conformation. 
  • Role of calcium-independent phospholipase A(2)β in human pancreatic islet β-cell apoptosis. 
  • Role of chaperones in antigen processing. 
  • Salicylic acid-independent role of NPR1 is required for protection from proteotoxic stress in the plant endoplasmic reticulum. 
  • Sar1 assembly regulates membrane constriction and ER export. 
  • Sel1L is indispensable for mammalian endoplasmic reticulum-associated degradation, endoplasmic reticulum homeostasis, and survival. 
  • Selective inhibition of eukaryotic translation initiation factor 2 alpha dephosphorylation potentiates fatty acid-induced endoplasmic reticulum stress and causes pancreatic beta-cell dysfunction and apoptosis. 
  • Selective inhibition of protein secretion by abrogating receptor-coat interactions during ER export. 
  • Signal sequence- and translation-independent mRNA localization to the endoplasmic reticulum. 
  • Similarities and differences in the pathogenesis of alcoholic and nonalcoholic steatohepatitis. 
  • Sodium 4-phenylbutyrate protects against liver ischemia reperfusion injury by inhibition of endoplasmic reticulum-stress mediated apoptosis. 
  • Sphingosine-1-phosphate phosphohydrolase regulates endoplasmic reticulum-to-golgi trafficking of ceramide. 
  • Spontaneous development of endoplasmic reticulum stress that can lead to diabetes mellitus is associated with higher calcium-independent phospholipase A2 expression: a role for regulation by SREBP-1. 
  • Stable ribosome binding to the endoplasmic reticulum enables compartment-specific regulation of mRNA translation. 
  • Stage- and ribosome-specific alterations in nascent chain-Sec61p interactions accompany translocation across the ER membrane. 
  • Stroma provides an intestinal stem cell niche in the absence of epithelial Wnts. 
  • Structural cues involved in endoplasmic reticulum degradation of G85E and G91R mutant cystic fibrosis transmembrane conductance regulator. 
  • Structural determinants for signal sequence function in the mammalian endoplasmic reticulum. 
  • Structure and folding of nascent polypeptide chains during protein translocation in the endoplasmic reticulum. 
  • Structure of the N-terminal domain of GRP94. Basis for ligand specificity and regulation. 
  • Subcellular changes in capillary endothelial cells during repair of hyperoxic lung injury. 
  • Succination of Protein Disulfide Isomerase Links Mitochondrial Stress and Endoplasmic Reticulum Stress in the Adipocyte During Diabetes. 
  • Synaptotagmin 17 controls neurite outgrowth and synaptic physiology via distinct cellular pathways. 
  • TMEM41B is a host factor required for the replication of diverse coronaviruses including SARS-CoV-2. 
  • The Early-Acting Peroxin PEX19 Is Redundantly Encoded, Farnesylated, and Essential for Viability in Arabidopsis thaliana. 
  • The angiotensin II type I receptor-associated protein, ATRAP, is a transmembrane protein and a modulator of angiotensin II signaling. 
  • The common variant of cystic fibrosis transmembrane conductance regulator is recognized by hsp70 and degraded in a pre-Golgi nonlysosomal compartment. 
  • The contribution of autophagy to lymphocyte survival and homeostasis. 
  • The cytoplasmic domain of a disintegrin and metalloproteinase 10 (ADAM10) regulates its constitutive activity but is dispensable for stimulated ADAM10-dependent shedding. 
  • The endoplasmic reticulum and neurological diseases. 
  • The fate of membrane-bound ribosomes following the termination of protein synthesis. 
  • The feelgood mutation in zebrafish dysregulates COPII-dependent secretion of select extracellular matrix proteins in skeletal morphogenesis. 
  • The final touches make perfect the peptide-MHC class I repertoire. 
  • The fine structure of three malignant melanomas of the iris. 
  • The immunity-related GTPase Irgm3 relieves endoplasmic reticulum stress response during coxsackievirus B3 infection via a PI3K/Akt dependent pathway. 
  • The immunological properties of endoplasmic reticulum chaperones: a conflict of interest? 
  • The inducibly expressed GTPase localizes to the endoplasmic reticulum, independently of GTP binding. 
  • The intestinal tuft cell nanostructure in 3D. 
  • The outer segment serves as a default destination for the trafficking of membrane proteins in photoreceptors. 
  • The secretory pathway in control of endoplasmic reticulum homeostasis. 
  • The segment polarity gene porcupine encodes a putative multitransmembrane protein involved in Wingless processing. 
  • The tetraspanin CD81 regulates the expression of CD19 during B cell development in a postendoplasmic reticulum compartment. 
  • The unfolded protein response triggers selective mRNA release from the endoplasmic reticulum. 
  • The yeast Rab GTPase Ypt1 modulates unfolded protein response dynamics by regulating the stability of HAC1 RNA. 
  • To find the road traveled to tumor immunity: the trafficking itineraries of molecular chaperones in antigen-presenting cells. 
  • Topology of mammalian isoprenylcysteine carboxyl methyltransferase determined in live cells with a fluorescent probe. 
  • Transfer of the Septin Ring to Cytokinetic Remnants in ER Stress Directs Age-Sensitive Cell-Cycle Re-entry. 
  • Tubular arrays on electron microscopy not specific. 
  • Tumor-induced reshuffling of lipid composition on the endoplasmic reticulum membrane sustains macrophage survival and pro-tumorigenic activity. 
  • Two kinetically-distinct components of UDP-glucuronic acid transport in rat liver endoplasmic reticulum. 
  • Two mechanistically distinct immune evasion proteins of cowpox virus combine to avoid antiviral CD8 T cells. 
  • Ubiquitin fold modifier 1 (UFM1) and its target UFBP1 protect pancreatic beta cells from ER stress-induced apoptosis. 
  • Unique evolution of the UPR pathway with a novel bZIP transcription factor, Hxl1, for controlling pathogenicity of Cryptococcus neoformans. 
  • Up-regulation of GRP78 and antiapoptotic signaling in murine peritoneal macrophages exposed to insulin. 
  • Visualizing Intracellular Organelle and Cytoskeletal Interactions at Nanoscale Resolution on Millisecond Timescales. 
  • WLS retrograde transport to the endoplasmic reticulum during Wnt secretion. 
  • Wnt traffic from endoplasmic reticulum to filopodia. 
  • Zinc transporter ZIP7 is a novel determinant of ferroptosis. 
  • mRNA translation is compartmentalized to the endoplasmic reticulum following physiological inhibition of cap-dependent translation. 
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  Keywords of People

  • Choi, Steven Sok, Associate Professor of Medicine, Medicine, Gastroenterology
  • McLendon, Roger Edwin, Professor of Pathology, Pathology
  • Taylor, Gregory Alan, Professor in Medicine, Integrative Immunobiology