Endothelium

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  Subject Areas on Research

  • 'Chimeric' grafts assembled from multiple allodisparate donors enjoy enhanced transplant survival. 
  • A biomimetic Schlemm's canal inner wall: A model to study outflow physiology, glaucoma pathology and high-throughput drug screening. 
  • A preliminary study on efficacy of rupatadine for the treatment of acute dengue infection. 
  • Absence of hyperacute rejection in pig-to-primate orthotopic pulmonary xenografts. 
  • Acid mucopolysaccharides in the outflow apparatus. 
  • Actigraphy-Derived Sleep Efficiency Is Associated With Endothelial Function in Men and Women With Untreated Hypertension. 
  • Age related changes in extracellular materials in the inner wall of Schlemm's canal. 
  • Age-related changes in the human outflow apparatus. 
  • An In Vitro Bovine Cellular Model for Human Schlemm's Canal Endothelial Cells and Their Response to TGFβ Treatment. 
  • Analysis of the corneal endothelium in keratoconus. 
  • Apoptosis of sinusoidal endothelial cells is a critical mechanism of preservation injury in rat liver transplantation. 
  • Arachidonic acid metabolism in cultured aortic endothelial cells. Effect of cAMP and 3-isobutyl-1-methylxanthine. 
  • Artificial surfactant attenuates hyperoxic lung injury in primates. II. Morphometric analysis. 
  • Associations between the cells of the walls of Schlemm's canal. 
  • Axenfeld-Rieger syndrome. A spectrum of developmental disorders. 
  • Blockade of the epidermal growth factor receptor signaling by a novel tyrosine kinase inhibitor leads to apoptosis of endothelial cells and therapy of human pancreatic carcinoma. 
  • Bovine retinal explants cultured in collagen gels. A model system for the study of proliferative retinopathy. 
  • Brain microvascular injury and white matter disease provoked by diabetes-associated hyperamylinemia. 
  • Calpain inhibition prevents sinusoidal endothelial cell apoptosis in the cold ischemic rat liver. 
  • Cell surface annexin II is a high affinity receptor for the alternatively spliced segment of tenascin-C. 
  • Characterization of prostate-tissue-directed monoclonal antibody, alpha-Pro 13. 
  • Comparison of aortic intima and inner media in young adult versus aging rats. Stereology in a polarized system. 
  • Comparison of the effect of polymethylmethacrylate and silicone intraocular lenses on rabbit corneal endothelium in vitro. 
  • Computational models of cancer cell transport through the microcirculation. 
  • Coordinated activation of corneal wound response genes in vivo as observed by in situ hybridization. 
  • Cytochrome P450IA1 induction and localization in endothelium of vertebrate (teleost) heart. 
  • Development of biologic markers of response and assessment of antiangiogenic activity in a clinical trial of human recombinant endostatin. 
  • Development of retinal neovascularisation in vascular occlusive disease. 
  • Diabetic retinopathy and risk of heart failure. 
  • Differential effect of secondary aqueous humor from rabbit and cat on DNA synthesis of cultured bovine corneal endothelial cells. 
  • Distribution and significance of hyaluronidase-sensitive materials in the trabecular wall of Schlemm's canal. 
  • Drug reservoirs in topical therapy. 
  • Effect of an anti-C5a monoclonal antibody indicates a prominent role for anaphylatoxin in pulmonary xenograft dysfunction. 
  • Effects of age and rapid high-pressure fixation on the morphology of Schlemm's canal. 
  • Effects of ammonium ion derived from bovine endothelial cells upon low density lipoprotein degradation in cultured vascular smooth muscle cells. 
  • Effects of prolonged intracameral perfusion with mock aqueous humour on the morphology of the primate outflow apparatus. 
  • Endothelial SUR-8 acts in an ERK-independent pathway during atrioventricular cushion development. 
  • Endothelial cell surface expression and binding of factor VIII/von Willebrand factor. 
  • Endothelial cells adhere to the RGD domain and the fibrinogen-like terminal knob of tenascin. 
  • Endothelial deletion of murine Jag1 leads to valve calcification and congenital heart defects associated with Alagille syndrome. 
  • Endothelial denudation and myointimal thickening in the rat carotid artery induced by the passage of bubbles. 
  • Endothelial renin-angiotensin pathway: evidence for intracellular synthesis and secretion of angiotensins. 
  • Enhancement of Outflow Facility in the Murine Eye by Targeting Selected Tight-Junctions of Schlemm's Canal Endothelia. 
  • Epinephrine-induced activation of LW-mediated sickle cell adhesion and vaso-occlusion in vivo. 
  • Evidence for disruption of sphingolipid metabolism as a contributing factor in the toxicity and carcinogenicity of fumonisins. 
  • Evidence from molecular cloning that SPARC, a major product of mouse embryo parietal endoderm, is related to an endothelial cell 'culture shock' glycoprotein of Mr 43,000. 
  • Experimental gliomas: an autoradiographic study of the endothelial component. 
  • Expression analysis of the T-cell-targeting chemokines CXCL9 and CXCL10 in mice and humans with endothelial infections caused by rickettsiae of the spotted fever group. 
  • Expression of the human leukocyte adhesion molecule, LAM1. Identity with the TQ1 and Leu-8 differentiation antigens. 
  • Fibrinogen-Coated Albumin Nanospheres Prevent Thrombocytopenia-Related Bleeding. 
  • Fibrotic Changes to Schlemm's Canal Endothelial Cells in Glaucoma. 
  • Function and evolutionary conservation of distinct epitopes on the leukocyte adhesion molecule-1 (TQ-1, Leu-8) that regulate leukocyte migration. 
  • Further observations on the process of haemophagocytosis in the human outflow system. 
  • Giant vacuoles in the lining endothelium of the human Schlemm's canal after topical timolol maleate. 
  • High vascular pressure-induced lung injury requires P450 epoxygenase-dependent activation of TRPV4. 
  • High-affinity augmentation of endothelial cell attachment: long-term effects on focal contact and actin filament formation. 
  • Histopathology of experimental preretinal neovascularization. 
  • Human splenic sinusoidal lining cells express antigens associated with monocytes, macrophages, endothelial cells, and T lymphocytes. 
  • Human thrombocytopenia is associated with structural abnormalities of the endothelium that are ameliorated by glucocorticosteroid administration. 
  • Hydraulic pressure stimulates adenosine 3',5'-cyclic monophosphate accumulation in endothelial cells from Schlemm's canal. 
  • Hydrogen peroxide production by alveolar type II cells, alveolar macrophages, and endothelial cells. 
  • Hypothesis: hyperhomocysteinemia is an indicator of oxidant stress. 
  • Immunogold localization of type IV collagen and laminin in the aging human outflow system. 
  • Immunohistochemical detection of factor VIII/von Willebrand factor in hyperplastic endothelial cells in glioblastoma multiforme and mixed glioma-sarcoma. 
  • Impaired systemic tetrahydrobiopterin bioavailability and increased dihydrobiopterin in adult falciparum malaria: association with disease severity, impaired microvascular function and increased endothelial activation. 
  • In vitro interleukin-6 treatment prevents mortality associated with fatty liver transplants in rats. 
  • Increased adhesion of erythrocytes to endothelial cells in diabetes mellitus. 
  • Inhibition of rat arterial smooth muscle cell proliferation by heparin. In vivo studies with anticoagulant and nonanticoagulant heparin. 
  • Interaction of EGF receptor and grb2 in living cells visualized by fluorescence resonance energy transfer (FRET) microscopy. 
  • Interendothelial claudin-5 expression depends on cerebral endothelial cell-matrix adhesion by β(1)-integrins. 
  • Intravenous fluid resuscitation is associated with septic endothelial glycocalyx degradation. 
  • Isolation, culture, and characterization of endothelial cells from Schlemm's canal. 
  • Late-outgrowth endothelial progenitors from patients with coronary artery disease: endothelialization of confluent stromal cell layers. 
  • Light microscopic quantitation of the endothelial vacuoles in Schlemm's canal. 
  • Liposome-mediated augmentation of superoxide dismutase in endothelial cells prevents oxygen injury. 
  • Localization of factor VIII/von Willebrand factor and glial fibrillary acidic protein in the hemangioblastoma: implications for stromal cell histogenesis. 
  • Locational stereology performed within sampling fields in rat aortic wall, a polarized tissue. 
  • McCarey-Kaufman (MK) organ culture and MK medium-shifted corneas. 
  • Mechanism of bradykinin-stimulated prostacyclin synthesis in porcine aortic endothelial cells. 
  • Metabolic cooperation between vascular endothelial cells and smooth muscle cells in co-culture: changes in low density lipoprotein metabolism. 
  • Microanastomotic response to needle and suture size. 
  • Micropatterning of poly(ethylene glycol) diacrylate hydrogels with biomolecules to regulate and guide endothelial morphogenesis. 
  • Microvascular inflammation in renal allograft biopsies assessed by endothelial and leukocyte co-immunostain: a retrospective study on reproducibility and clinical/prognostic correlates. 
  • Molecular biology of chronic thromboembolic pulmonary hypertension. 
  • Morphologic aspects of the protection by endotoxin against acute and chronic oxygen-induced lung injury in adult rats. 
  • Multiple hyperacute rejections in the absence of detectable complement activation in a patient with endothelial cell reactive antibody. 
  • Natural surfactant and hyperoxic lung injury in primates. II. Morphometric analyses. 
  • Ocular pathology of Fabry's disease in a hemizygous male following renal transplantation. 
  • Pathophysiology and clinical evaluation of acute heart failure. 
  • Pigment epithelium-derived factor decreases outflow facility. 
  • Platelets induce sinusoidal endothelial cell apoptosis upon reperfusion of the cold ischemic rat liver. 
  • Possible prorenin activating mechanisms in the blood vessel wall. 
  • Pressure effects on flow channels in the lining endothelium of Schlemm's canal. A quantitative study by transmission electron microscopy. 
  • Pressure effects on the distribution of extracellular materials in the rhesus monkey outflow apparatus. 
  • Pressure effects on the endothelium of the trabecular wall of Schlemm's canal: a study by scanning electron microscopy. 
  • Pressure-induced changes in the ultrastructure of the endothelium lining Schlemm's canal. 
  • Promoter polymorphism (-786t>C) in the endothelial nitric oxide synthase gene is associated with risk of sporadic breast cancer in non-Hispanic white women age younger than 55 years. 
  • Protease-cleaved iron-transferrin augments oxidant-mediated endothelial cell injury via hydroxyl radical formation. 
  • Protective effects of ischemic preconditioning on the cold-preserved liver are tyrosine kinase dependent. 
  • Protein kinase C inhibition abrogates hepatic ischemic preconditioning responses. 
  • Regulation of factor IXa in vitro in human and mouse plasma and in vivo in the mouse. Role of the endothelium and the plasma proteinase inhibitors. 
  • Regulation of factor Xa in vitro in human and mouse plasma and in vivo in mouse. Role of the endothelium and plasma proteinase inhibitors. 
  • Renin expression by vascular endothelial cells in culture. 
  • Retinal neovascularisation arising from hyalinised blood vessels. 
  • SARS-CoV-2 has not been detected directly by electron microscopy in the endothelium of chilblain lesions. 
  • Secondary aqueous humor stimulates the proliferation of cultured bovine corneal endothelial cells. 
  • Selectins: a family of adhesion receptors. 
  • Sex hormones and renal nitric oxide synthases. 
  • Simian virus 40-induced retinopathy in the rat. 
  • Smooth muscle growth and cholesterol accumulation in atherogenesis. 
  • Soluble L-selectin is present in human plasma at high levels and retains functional activity. 
  • Synergism between platelets and leukocytes in inducing endothelial cell apoptosis in the cold ischemic rat liver: a Kupffer cell-mediated injury. 
  • Synergistic actions of hematopoietic and mesenchymal stem/progenitor cells in vascularizing bioengineered tissues. 
  • The NF-kappa B inhibitor, tepoxalin, suppresses surface expression of the cell adhesion molecules CD62E, CD11b/CD18 and CD106. 
  • The appearance of the outflow apparatus of the eye after staining with ruthenium red. 
  • The changing paradigm of outflow resistance generation: towards synergistic models of the JCT and inner wall endothelium. 
  • The dichotomous role of nitric oxide in the pathogenesis of accelerated atherosclerosis associated with systemic lupus erythematosus. 
  • The effect of silicone oil on the cornea. 
  • The effects of topical pilocarpine on the morphology of the outflow apparatus of the baboon (Papio cynocephalus). 
  • The fate of human platelets exposed to porcine renal endothelium: a single-pass model of platelet uptake in domestic and genetically modified porcine organs. 
  • The fine structure of the trabecular meshwork at graded levels of intraocular pressure. (1) Pressure effects within the near-physiological range (8-30 mmHg). 
  • The fine structure of the trabecular meshwork at graded levels of intraocular pressure. (2) Pressures outside the physiological range (0 and 50 mmHg). 
  • The relationship between cardiac endothelium and fibroblasts: it's complicated. 
  • The role of adhesive receptor patterns on cell transport in complex microvessels. 
  • The role of calcium in the regulation of prostacyclin synthesis by porcine aortic endothelial cells. 
  • The trabecular wall of Schlemm's canal: a study of the effects of pilocarpine by scanning electron microscopy. 
  • Transient receptor potential vanilloid 4-mediated disruption of the alveolar septal barrier: a novel mechanism of acute lung injury. 
  • Tyrosine 1101 of Tie2 is the major site of association of p85 and is required for activation of phosphatidylinositol 3-kinase and Akt. 
  • Ultrastructural pathology of melanomalytic glaucoma. 
  • Upregulation of miR21 and repression of Grhl3 by leptin mediates sinusoidal endothelial injury in experimental nonalcoholic steatohepatitis. 
  • Variation in the level of xenoantigen expression in porcine organs. 
  • Vascular wall renin-angiotensin pathway in control of the circulation. A hypothesis. 
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  Keywords of People

  • Erickson, Harold Paul, James B. Duke Distinguished Professor Emeritus, Cell Biology
  • Hogan, Brigid L. M., Research Professor of Cell Biology, Cell Biology