Endotoxins

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  Subject Areas on Research

  • A controlled clinical trial of E5 murine monoclonal IgM antibody to endotoxin in the treatment of gram-negative sepsis. The XOMA Sepsis Study Group. 
  • A neutrophil chemotatic factor derived from C'5 upon interaction of guinea pig serum with endotoxin. 
  • A selective inhibitor of cyclooxygenase-2 reverses endotoxin-induced pyretic responses in non-human primates. 
  • Abnormal production of interleukin-1 by microglia from trisomy 16 mice. 
  • Activation of complement by endotoxin. 
  • Activation of complement by endotoxin: a role for 2 globulin, C1, C4 and C2 in the consumption of terminal complement components by endotoxin-coated erythrocytes. 
  • Alkaline Phosphatase Activity and Endotoxemia After Infant Cardiothoracic Surgery. 
  • Alteration in regulation of inflammatory response to influenza a virus and endotoxin in suckling rat pups: a potential relationship to sudden infant death syndrome. 
  • Altered cell-averaged microviscosity of murine peritoneal macrophages undergoing activation in vivo or in vitro. 
  • Anti-mouse mesangial cell serum induces acute glomerulonephropathy in mice. 
  • Anti-phospholipid human monoclonal antibodies inhibit CCR5-tropic HIV-1 and induce beta-chemokines. 
  • Aseptic peritonitis with home peritoneal dialysis. 
  • Bactericidal antibiotics increase tumor necrosis factor-alpha and cardiac output in rats after cecal ligation and puncture. 
  • Beta-arrestin-2 regulates the development of allergic asthma. 
  • Biological activity of complement in vivo. Role of C5 in the accumulation of polymorphonuclear leukocytes in inflammatory exudates. 
  • Brucellosis. Indications for splenectomy. 
  • Byssinosis and respiratory diseases of cotton mill workers. 
  • CD14-dependent mechanism for endotoxin-mediated nitric oxide synthesis in murine macrophages. 
  • Characterization of short range DNA looping in endotoxin-mediated transcription of the murine inducible nitric-oxide synthase (iNOS) gene. 
  • Chemotaxis of inflammatory cells. 
  • Cholera toxin and cell growth: role of membrane gangliosides. 
  • Consumption of hamster complement by bacterial endotoxin. 
  • Cyclic AMP modulates the functional plasticity of immature dendritic cells by inhibiting Src-like kinases through protein kinase A-mediated signaling. 
  • Effect of C4 depletion on the utilization of the terminal components of guinea-pig complement by endotoxin. 
  • Effect of endotoxin and alum adjuvant vaccine on peanut allergy. 
  • Effects of antifungal agents and gamma interferon on macrophage cytotoxicity for fungi and tumor cells. 
  • Effects of bacterial lipopolysaccharide on the hydrolysis of phosphatidylinositol-4,5-bisphosphate in murine peritoneal macrophages. 
  • Endotoxin (LPS) stimulates in vitro migration of macrophages from LPS-resistant mice but not from LPS-sensitive mice. 
  • Endotoxin content in neonatal formulas, fortification, and lactoferrin products: association with outcomes and guidance on acceptable limits. 
  • Endotoxin mediated-iNOS induction causes insulin resistance via ONOO⁻ induced tyrosine nitration of IRS-1 in skeletal muscle. 
  • Endotoxin stress-response in cardiomyocytes: NF-kappaB activation and tumor necrosis factor-alpha expression. 
  • Endotoxin-induced uveitis in the rat: observations on altered vascular permeability, clinical findings, and histology. 
  • Endotoxin-mediated synthesis of nitric oxide is dependent on Gq protein signal transduction. 
  • Epidemiology, pathophysiology and clinical presentation of gram-negative sepsis. 
  • Essential roles of S-nitrosothiols in vascular homeostasis and endotoxic shock. 
  • Further characterization of a factor from endotoxin-treated serum which releases histamine and heparin from mast cells. 
  • Gene expression signatures of radiation response are specific, durable and accurate in mice and humans. 
  • Globin attenuates the innate immune response to endotoxin. 
  • Glucocorticoid therapy in sepsis/shock caused by gram-negative microorganisms. 
  • Glutamine induces heat shock protein and protects against endotoxin shock in the rat. 
  • Gut barrier dysfunction in the Apc(Min/+) mouse model of colon cancer cachexia. 
  • Human alveolar and peritoneal macrophages mediate fungistasis independently of L-arginine oxidation to nitrite or nitrate. 
  • Humoral mediators of chemotaxis of mononuclear leukocytes. 
  • Immune fever in the rabbit: responses of the hematologic and complement systems. 
  • Immunological mechanisms of periodontal tissue destruction. 
  • Induction of ferritin and heme oxygenase-1 by endotoxin in the lung. 
  • Inhibition of the inositol triphosphate receptor increases endotoxin-mediated nitric oxide synthesis in macrophages. 
  • Interaction of TLR2 and TLR4 ligands with the N-terminal domain of Gp96 amplifies innate and adaptive immune responses. 
  • Interaction of complex polysaccharides with the complement system: effect of calcium depletion on terminal component consumption. 
  • Interaction of platelet-activating factor, spleen and atrial natriuretic peptide in plasma volume regulation during endotoxaemia in rats. 
  • Interactions of the complement system with endotoxic lipopolysaccharide. Generation of a factor chemotactic for polymorphonuclear leukocytes. 
  • Intravascular coagulation--a source of possible error in carbon-clearance determinations. 
  • Limulus amebocyte lysate test in neonates. 
  • Low-level endotoxin induces potent inflammatory activation of human blood vessels: inhibition by statins. 
  • Lower endotoxin immunity predicts increased cognitive dysfunction in elderly patients after cardiac surgery. 
  • Lymphocyte responses to purified ragweed allergens in vitro. I. Proliferative responses in normal, newborn, agammaglobulinemic, and atopic subjects. 
  • Macrophage tumor killing: influence of the local environment. 
  • Mediators of pulmonary injury induced by inhalation of bacterial endotoxin. 
  • Metabolic factors associated with endotoxin-induced tolerance for hemorrhagic shock. 
  • Modification of a commercial cell sorter to support efficient and reliable preparation of ALDH-bright cells for clinical use. 
  • Modulation of the tumoricidal function of activated macrophages by bacterial endotoxin and mammalian macrophage activation factor (s). 
  • Morphologic aspects of the protection by endotoxin against acute and chronic oxygen-induced lung injury in adult rats. 
  • Morphometric changes of the lung induced by inhaled bacterial endotoxin. 
  • Newly Developed Recombinant Antithrombin Protects the Endothelial Glycocalyx in an Endotoxin-Induced Rat Model of Sepsis. 
  • Non-neurogenic stimulation of adrenomedullary secretion during endotoxicosis in the one day old rat. 
  • Nonalcoholic fatty liver disease: implications for alcoholic liver disease pathogenesis. 
  • Partial liquid ventilation influences pulmonary histopathology in an animal model of acute lung injury. 
  • Partial liquid ventilation with perflubron attenuates in vivo oxidative damage to proteins and lipids. 
  • Periodontal disease: a model for the study of inflammation. 
  • Pharmacological stimulation of the cholinergic antiinflammatory pathway. 
  • Photoperiodic adjustments in immune function protect Siberian hamsters from lethal endotoxemia. 
  • Priming with endotoxin increases acute lung injury in mice by enhancing the severity of lung endothelial injury. 
  • Protection of the endothelial glycocalyx by antithrombin in an endotoxin-induced rat model of sepsis. 
  • Protocol to measure endotoxin from opaque tissues in mice using an optimized kinetic limulus amebocyte lysate assay. 
  • Quantification of mouse macrophage chemotaxis in vitro: role of C5 for the production of chemotactic activity. 
  • Regulation of endotoxin-induced proinflammatory activation in human coronary artery cells: expression of functional membrane-bound CD14 by human coronary artery smooth muscle cells. 
  • Role for endotoxin and complement in periodontal tissue destruction. 
  • S-nitrosylation of heterogeneous nuclear ribonucleoprotein A/B regulates osteopontin transcription in endotoxin-stimulated murine macrophages. 
  • Significance of complement to the mechanism of action of endotoxin. 
  • Strain variation in antiphagocytic activity of capsular polysaccharides from Cryptococcus neoformans serotype A. 
  • Sudden infant death syndrome: a toxic response. 
  • Suppression of HMGB1 release by stearoyl lysophosphatidylcholine:an additional mechanism for its therapeutic effects in experimental sepsis. 
  • Synergistic effect of influenza a virus on endotoxin-induced mortality in rat pups: a potential model for sudden infant death syndrome. 
  • The inflammatory response and resistance to endotoxin in mice. 
  • The role of the immune response in the development of periodontal disease. 
  • Toll-like receptor 4 antagonist (E5564) prevents the chronic airway response to inhaled lipopolysaccharide. 
  • Treatment of neuroinflammation by soluble tumor necrosis factor receptor Type II fused to a thermally responsive carrier. 
  • alpha-Melanocyte-stimulating hormone infused ICV fails to affect body temperature or endotoxin fever in the cat. 
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  Keywords of People

  • Bennett, Vann, George Barth Geller Distinguished Professor of Molecular Biology, Duke Cancer Institute
  • Laskowitz, Daniel Todd, Professor of Neurology, Duke Science & Society