Enkephalins
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Subject Areas on Research
- A functional prodynorphin promoter polymorphism and opioid dependence.
- A novel nonopioid action of enkephalins: competitive inhibition of the mammalian brain high affinity L-proline transporter.
- Agonist-dependent phosphorylation of the mouse delta-opioid receptor: involvement of G protein-coupled receptor kinases but not protein kinase C.
- Altered genetic response to beta-adrenergic receptor activation in late passage C6 glioma cells.
- Ancient and recent positive selection transformed opioid cis-regulation in humans.
- Behavioral activation by enkephalins in mice.
- Clinical Correlates and Prognostic Value of Proenkephalin in Acute and Chronic Heart Failure.
- Cyclic AMP, morphine, met-enkephalin and neuronal firing.
- Delta-opioid-receptor activation by [D-Pen2,D-Pen5]enkephalin and morphine inhibits substance P release from trigeminal nucleus slices.
- Distribution of opioid peptide gene expression in the limbic system of Fawn-Hooded (alcohol-preferring) and Wistar-Kyoto (alcohol-non-preferring) rats.
- ERK MAP kinase activation in superficial spinal cord neurons induces prodynorphin and NK-1 upregulation and contributes to persistent inflammatory pain hypersensitivity.
- Early ontogeny of kappa-opioid receptor regulation of prolactin secretion in the rat.
- Enkephalin-dopamine interactions in behavioral arousal.
- Enkephalin-like immunoreactivity in the mossy fiber pathway of the hippocampal formation of the tree shrew (Tupaia glis).
- Estrogen and thyroid hormone interaction on regulation of gene expression.
- Gene therapy of bladder pain with herpes simplex virus (HSV) vectors expressing preproenkephalin (PPE).
- Glutamate and dynorphin release from a subcellular fraction enriched in hippocampal mossy fiber synaptosomes.
- Heterogeneity in presynaptic regulation of GABA release from hippocampal inhibitory neurons.
- High-threshold Ca2+ currents in rat hippocampal interneurones and their selective inhibition by activation of GABA(B) receptors.
- Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter.
- Identifying local and descending inputs for primary sensory neurons.
- Implanted reuptake-deficient or wild-type dopaminergic neurons improve ON L-dopa dyskinesias without OFF-dyskinesias in a rat model of Parkinson's disease.
- In vitro assays fail to predict in vivo effects of regulatory polymorphisms.
- Interactions between cardiovascular and pain regulatory systems.
- K-ras mutation and p16 and preproenkephalin promoter hypermethylation in plasma DNA of pancreatic cancer patients: in relation to cigarette smoking.
- Mechanisms of pain perception in patients with silent myocardial ischemia.
- Methionine-enkephalin and morphine: amount ejected microiontophoretically.
- Molecular characterization of the human delta opioid receptor in lung cancer.
- Morphine and methionine-enkephalin: different effects on spontaneous and evoked neuronal firing in the mesencephalic reticular formation of the rat.
- Multiple Functional Variants in cis Modulate PDYN Expression.
- Neurohormonal peptides in ovarian carcinoids: an immunohistochemical study of 81 primary carcinoids and of intraovarian metastases from six mid-gut carcinoids.
- Neuropathic pain activates the endogenous kappa opioid system in mouse spinal cord and induces opioid receptor tolerance.
- Opioid inhibition of rapid eye movement sleep by a specific mu receptor agonist.
- Opioid regulation of hypothalamic-pituitary-adrenal function in depression.
- Secondary structure creates mismatched base pairs required for high-affinity binding of cAMP response element-binding protein to the human enkephalin enhancer.
- Sensitive analysis of [D-Pen2,5]enkephalin in rat serum by capillary electrophoresis and laser-induced fluorescence detection.
- Serotonin depletion exacerbates changes in striatal gene expression following quinolinic acid injection.
- Voltage-dependent effects of opioid peptides on hippocampal CA3 pyramidal neurons in vitro.
- [Analgesic effect of intrathecal injection of Herpes simplex virus type I amplicon vector-mediated human preproenkephalin gene on chronic neuropathic pain: experiment with rats].
- [Electroacupuncture enhances enkephalin mRNA expression in the spinal cord and medulla, an in situ hybridization study].
- [Intrathecal administration of HSV-I amplicon vector-mediated HPPE gene therapy of nocicepion in rats with formalin pain].
- [Proto-oncogene and pain modulation].
- mu-Opioid agonists stimulate growth hormone secretion in immature rats.
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Keywords of People
- Wray, Gregory Allan, Professor of Biology, Duke Innovation & Entrepreneurship