Enzyme Inhibitors

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  Subject Areas on Research

  • "Synthesis of 5-ethynyl-2'-deoxyuridine-5'-boranomonophosphate as a Potential Thymidylate Synthase Inhibitor" 
  • 2.3 Å resolution cryo-EM structure of human p97 and mechanism of allosteric inhibition. 
  • 3-Aminopyrrolidinone farnesyltransferase inhibitors: design of macrocyclic compounds with improved pharmacokinetics and excellent cell potency. 
  • 3-nitrotyrosine attenuates respiratory syncytial virus infection in human bronchial epithelial cell line. 
  • A 2-pyridone-amide inhibitor targets the glucose metabolism pathway of Chlamydia trachomatis. 
  • A CORRELATION BETWEEN THE PROTEIN STRUCTURE AND CATALYTIC ACTIVITY OF ASPARTATE AMINOTRANSFERASE. 
  • A Double-Blind, Randomized, Placebo-Controlled Trial of Soluble Epoxide Hydrolase Inhibition in Patients with Aneurysmal Subarachnoid Hemorrhage. 
  • A GH3-like domain in reaper is required for mitochondrial localization and induction of IAP degradation. 
  • A Phase 2 Study of AMO-02 (Tideglusib) in Congenital and Childhood-Onset Myotonic Dystrophy Type 1 (DM1). 
  • A Phase I trial of preoperative eniluracil plus 5-fluorouracil and radiation for locally advanced or unresectable adenocarcinoma of the rectum and colon. 
  • A Predictive Model for Selective Targeting of the Warburg Effect through GAPDH Inhibition with a Natural Product. 
  • A Screen for Extracellular Signal-Regulated Kinase-Primed Glycogen Synthase Kinase 3 Substrates Identifies the p53 Inhibitor iASPP. 
  • A beta-lactam inhibitor of cytosolic phospholipase A2 which acts in a competitive, reversible manner at the lipid/water interface. 
  • A comparison of Zn2+- and Ca2+-triggered depolarization of liver mitochondria reveals no evidence of Zn2+-induced permeability transition. 
  • A decade of caspases. 
  • A glucan synthase FKS1 homolog in cryptococcus neoformans is single copy and encodes an essential function. 
  • A high-performance liquid chromatography method for the quantification of cysmethynil, an inhibitor of isoprenylcysteine carboxylmethyl transferase, in mouse plasma. 
  • A mouse model of familial porphyria cutanea tarda. 
  • A new link between the c-Abl tyrosine kinase and phosphoinositide signalling through PLC-gamma1. 
  • A non-transformed oligodendrocyte precursor cell line, OL-1, facilitates studies of insulin-like growth factor-I signaling during oligodendrocyte development. 
  • A novel antisense inhibitor of MMP-9 attenuates angiogenesis, human prostate cancer cell invasion and tumorigenicity. 
  • A novel low-molecular weight inhibitor of focal adhesion kinase, TAE226, inhibits glioma growth. 
  • A novel protein geranylgeranyltransferase-I inhibitor with high potency, selectivity, and cellular activity. 
  • A peptide inhibitor derived from p55PIK phosphatidylinositol 3-kinase regulatory subunit: a novel cancer therapy. 
  • A phase I study of eniluracil/5-FU in combination with radiation therapy for potentially resectable and/or unresectable cancer of the pancreas and distal biliary tract. 
  • A phase I study of the safety and pharmacokinetics of edotecarin (J-107088), a novel topoisomerase I inhibitor, in patients with advanced solid tumors. 
  • A phase I trial of the farnesyl transferase inhibitor, SCH 66336, with temozolomide for patients with malignant glioma. 
  • A phase I/IIa clinical trial of a recombinant Rho protein antagonist in acute spinal cord injury. 
  • A phase II trial of O6-benzylguanine and carmustine in patients with advanced soft tissue sarcoma. 
  • A phase III, randomized, double-blind, placebo-controlled study of peldesine (BCX-34) cream as topical therapy for cutaneous T-cell lymphoma. 
  • A phase Ib study of the combination regorafenib with PF-03446962 in patients with refractory metastatic colorectal cancer (REGAL-1 trial). 
  • A randomized controlled trial of allopurinol vs. placebo added on to antipsychotics in patients with schizophrenia or schizoaffective disorder. 
  • A role for Cdc2- and PP2A-mediated regulation of Emi2 in the maintenance of CSF arrest. 
  • A role for a lithium-inhibited Golgi nucleotidase in skeletal development and sulfation. 
  • A role for the thromboxane receptor in L-NAME hypertension. 
  • A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress. 
  • A slow, tight-binding inhibitor of the zinc-dependent deacetylase LpxC of lipid A biosynthesis with antibiotic activity comparable to ciprofloxacin. 
  • A small interfering RNA screen for modulators of tumor cell motility identifies MAP4K4 as a promigratory kinase. 
  • A small molecule inhibitor of isoprenylcysteine carboxymethyltransferase induces autophagic cell death in PC3 prostate cancer cells. 
  • A small-molecule inhibitor of isoprenylcysteine carboxyl methyltransferase with antitumor activity in cancer cells. 
  • A small-molecule probe of the histone methyltransferase G9a induces cellular senescence in pancreatic adenocarcinoma. 
  • A sphingosine kinase inhibitor induces cell death in temozolomide resistant glioblastoma cells. 
  • A synthetic peptide homologous to retroviral transmembrane envelope proteins depresses protein kinase C mediated lymphocyte proliferation and directly inactivated protein kinase C: a potential mechanism for immunosuppression. 
  • A tissue-engineered human trabecular meshwork hydrogel for advanced glaucoma disease modeling. 
  • A unique type II topoisomerase mutant that is hypersensitive to a broad range of cleavage-inducing antitumor agents. 
  • A3 adenosine and CB1 receptors activate a PKC-sensitive Cl- current in human nonpigmented ciliary epithelial cells via a G beta gamma-coupled MAPK signaling pathway. 
  • ACC/AHA expert consensus document. Use of sildenafil (Viagra) in patients with cardiovascular disease. American College of Cardiology/American Heart Association. 
  • AKT1 mediates bypass of the G1/S checkpoint after genotoxic stress in normal human cells. 
  • AT1 blockade prevents glucose-induced cardiac dysfunction in ventricular myocytes: role of the AT1 receptor and NADPH oxidase. 
  • Aberrant expression of tumor suppressor proteins in the Ewing family of tumors. 
  • Absence of progeria-like disease phenotypes in knock-in mice expressing a non-farnesylated version of progerin. 
  • Abundant expression of ponsin, a focal adhesion protein, in lens and downregulation of its expression by impaired cytoskeletal signaling. 
  • Acetyl-CoA:1-O-alkyl-2-lyso-sn-glycero-3-phosphocholine acetyltransferase is directly activated by p38 kinase. 
  • Activated forms of H-RAS and K-RAS differentially regulate membrane association of PI3K, PDK-1, and AKT and the effect of therapeutic kinase inhibitors on cell survival. 
  • Activated αvβ3 integrin regulates αvβ5 integrin-mediated phagocytosis in trabecular meshwork cells. 
  • Activation of Akt/PDK signaling in macrophages upon binding of receptor-recognized forms of alpha2-macroglobulin to its cellular receptor: effect of silencing the CREB gene. 
  • Activation of EGF receptors mediates pulmonary vasoconstriction induced by residual oil fly ash. 
  • Activation of MEF2 by muscle activity is mediated through a calcineurin-dependent pathway. 
  • Activation of the PI3K/Akt pathway and chemotherapeutic resistance. 
  • Activation of the sphingomyelin cycle by brefeldin A: effects of brefeldin A on differentiation and implications for a role for ceramide in regulation of protein trafficking. 
  • Activation of tyrosine kinases in cancer. 
  • Active involvement of PKC for insulin-mediated rates of muscle protein synthesis in Zucker rats. 
  • Acute pancreatitis associated with administration of a nitric oxide synthase inhibitor in tumor-bearing dogs. 
  • Acyl-CoAs are functionally channeled in liver: potential role of acyl-CoA synthetase. 
  • Addendum to Letter to the Editor: Safety, efficacy, and authorization of eliglustat as a first-line therapy in Gaucher disease type 1. 
  • Adenylosuccinate Is an Insulin Secretagogue Derived from Glucose-Induced Purine Metabolism. 
  • Akt/protein kinase B is constitutively active in non-small cell lung cancer cells and promotes cellular survival and resistance to chemotherapy and radiation. 
  • Alpha-adducin dissociates from F-actin and spectrin during platelet activation. 
  • Alpha-fodrin is cleaved by caspase-3 in a chronic ocular hypertensive (COH) rat model of glaucoma. 
  • Alteration in sphingolipid metabolism: bioassays for fumonisin- and ISP-I-like activity in tissues, cells and other matrices. 
  • Alterations in calcium metabolism in murine macrophages by the benzene metabolite 1,4-benzoquinone. 
  • Alterations in gene expression induced by cyclic mechanical stress in trabecular meshwork cells. 
  • Altered cyclic AMP-dependent human chorionic gonadotropin production in cultured human placental trophoblasts exposed to ethanol. 
  • Altered protein kinase C (PKC) isoforms in non-small cell lung cancer cells: PKCdelta promotes cellular survival and chemotherapeutic resistance. 
  • Alternative activation of extracellular signal-regulated protein kinases in curcumin and arsenite-induced HSP70 gene expression in human colorectal carcinoma cells. 
  • American Society of Clinical Oncology technology assessment of pharmacologic interventions for breast cancer risk reduction including tamoxifen, raloxifene, and aromatase inhibition. 
  • Aminoguanidine inhibits reactive oxygen species formation, lipid peroxidation, and oxidant-induced apoptosis. 
  • An Inhibitor of the F1 subunit of ATP synthase (IF1) modulates the activity of angiostatin on the endothelial cell surface. 
  • An activity necessary for in vitro transcription is a DNase inhibitor. 
  • An unbiased evaluation of CK2 inhibitors by chemoproteomics: characterization of inhibitor effects on CK2 and identification of novel inhibitor targets. 
  • Androgens and masculinization of genitalia in the spotted hyaena (Crocuta crocuta). 2. Effects of prenatal anti-androgens. 
  • Angiotensin II attenuates chemical hypoxia-induced caspase-3 activation in primary cortical neuronal cultures. 
  • Antibody binding to a conformation-dependent epitope induces L-selectin association with the detergent-resistant cytoskeleton. 
  • Antidepressant actions of histone deacetylase inhibitors. 
  • Antifungal activity of compounds targeting the Hsp90-calcineurin pathway against various mould species. 
  • Antioxidant responses and NRF2 in synergistic developmental toxicity of PAHs in zebrafish. 
  • Antiretroviral intensification and valproic acid lack sustained effect on residual HIV-1 viremia or resting CD4+ cell infection. 
  • Apolipoprotein E Exerts a Whole-Brain Protective Property by Promoting M1? Microglia Quiescence After Experimental Subarachnoid Hemorrhage in Mice. 
  • Apoptosis as a host defense mechanism in Crassostrea virginica and its modulation by Perkinsus marinus. 
  • Apoptosis in Drosophila: neither fish nor fowl (nor man, nor worm). 
  • Apoptosis induces expression of sphingosine kinase 1 to release sphingosine-1-phosphate as a "come-and-get-me" signal. 
  • Apparent elastic modulus and hysteresis of skeletal muscle cells throughout differentiation. 
  • Appendices. Kinetic models for the analysis of modulation and suppression of irreversible enzymatic inhibition. 
  • Assignment of the 1H, 13C and 15N resonances of the LpxC deacetylase from Aquifex aeolicus in complex with the substrate-analog inhibitor TU-514. 
  • Autophagy-dependent metabolic reprogramming sensitizes TSC2-deficient cells to the antimetabolite 6-aminonicotinamide. 
  • Bacterial endotoxin stimulates macrophages to release HMGB1 partly through CD14- and TNF-dependent mechanisms. 
  • Bacteriophage T4, a model system for understanding the mechanism of type II topoisomerase inhibitors. 
  • Basis for resistance to 3-deazaaristeromycin, an inhibitor of S-adenosylhomocysteine hydrolase, in human B-lymphoblasts. 
  • Benzimidazole and Benzoxazole Zinc Chelators as Inhibitors of Metallo-β-Lactamase NDM-1. 
  • Benzo(a)pyrene inhibits expression of inducible heat shock protein 70 in vascular endothelial cells. 
  • Bi-directional migration of lens epithelial cells in a physiological electrical field. 
  • Binding of activated alpha2-macroglobulin to its cell surface receptor GRP78 in 1-LN prostate cancer cells regulates PAK-2-dependent activation of LIMK. 
  • Binding of anti-GRP78 autoantibodies to cell surface GRP78 increases tissue factor procoagulant activity via the release of calcium from endoplasmic reticulum stores. 
  • Binding of receptor-recognized forms of alpha2-macroglobulin to the alpha2-macroglobulin signaling receptor activates phosphatidylinositol 3-kinase. 
  • Biochemical modulation of 5-fluorouacil through dihydropyrimidine dehydrogenase inhibition: a Southwest Oncology Group phase II trial of eniluracil and 5-fluorouracil in advanced resistant colorectal cancer. 
  • Biochemical recurrence of prostate cancer. 
  • Biomarker bonanza? 
  • Birinapant Enhances Gemcitabine's Antitumor Efficacy in Triple-Negative Breast Cancer by Inducing Intrinsic Pathway-Dependent Apoptosis. 
  • Blockade of the extracellular signal-regulated kinase pathway by U0126 attenuates neuronal damage following circulatory arrest. 
  • Brain cancer stem cells display preferential sensitivity to Akt inhibition. 
  • Brain tumors in mice are susceptible to blockade of epidermal growth factor receptor (EGFR) with the oral, specific, EGFR-tyrosine kinase inhibitor ZD1839 (iressa). 
  • Bullous systemic lupus erythematosus in a 6-year-old boy. 
  • Bypass of hexavalent chromium-induced growth arrest by a protein tyrosine phosphatase inhibitor: enhanced survival and mutagenesis. 
  • C2-symmetrical tetrahydroxyazepanes as inhibitors of glycosidases and HIV/FIV proteases. 
  • CCI-779 inhibits cell-cycle G2-M progression and invasion of castration-resistant prostate cancer via attenuation of UBE2C transcription and mRNA stability. 
  • CD14-dependent mechanism for endotoxin-mediated nitric oxide synthesis in murine macrophages. 
  • CD19 amplification of B lymphocyte Ca2+ responses: a role for Lyn sequestration in extinguishing negative regulation. 
  • CLL cell apoptosis induced by nitric oxide synthase inhibitors: correlation with lipid solubility and NOS1 dissociation constant. 
  • Caged protein prenyltransferase substrates: tools for understanding protein prenylation. 
  • Calcineurin inhibition or mutation enhances cell wall inhibitors against Aspergillus fumigatus. 
  • Calcineurin mediates pancreatic growth in protease inhibitor-treated mice. 
  • Calcineurin regulates cyclin D1 accumulation in growth-stimulated fibroblasts. 
  • Calmodulin overexpression causes Ca(2+)-dependent apoptosis of pancreatic beta cells, which can be prevented by inhibition of nitric oxide synthase. 
  • Camptothecin analogues with enhanced antitumor activity at acidic pH. 
  • Camptothecin and Fas receptor agonists synergistically induce medulloblastoma cell death: ROS-dependent mechanisms. 
  • Can O6-alkylguanine-DNA alkyltransferase depletion enhance alkylator activity in the clinic? 
  • Cancer. A radical approach to treatment. 
  • Caspase-3 dependent cleavage and activation of skeletal muscle phosphorylase b kinase. 
  • Caspase-dependent cleavage of carbamoyl phosphate synthetase II during apoptosis. 
  • Cell cycle control of BRCA2. 
  • Cell cycle effects of nonsteroidal anti-inflammatory drugs and enhanced growth inhibition in combination with gemcitabine in pancreatic carcinoma cells. 
  • Cell cycle-independent death of prostate adenocarcinoma is induced by the trk tyrosine kinase inhibitor CEP-751 (KT6587). 
  • Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms. 
  • Cellular mechanisms regulating protein phosphatase-1. A key functional interaction between inhibitor-2 and the type 1 protein phosphatase catalytic subunit. 
  • Central glucagon like peptide-1 delays solid gastric emptying via central CRF and peripheral sympathetic pathway in rats. 
  • Central regulation of photosensitive membrane turnover in the lateral eye of Limulus, II: octopamine acts via adenylate cyclase/cAMP-dependent protein kinase to prime the retina for transient rhabdom shedding. 
  • Changes in osmolality sensitize the response to capsaicin in trigeminal sensory neurons. 
  • Characterization of PDK2 activity against protein kinase B gamma. 
  • Characterization of a human plasma membrane heme transporter in intestinal and hepatocyte cell lines. 
  • Characterization of a putative insulin-responsive element and its binding protein(s) in rat angiotensinogen gene promoter: regulation by glucose and insulin. 
  • Characterization of a selective inhibitor of inositol hexakisphosphate kinases: use in defining biological roles and metabolic relationships of inositol pyrophosphates. 
  • Characterization of cell-cycle arrest by fumonisin B1 in CV-1 cells. 
  • Chemical logic of MraY inhibition by antibacterial nucleoside natural products. 
  • Chemoinformatic identification of novel inhibitors against Mycobacterium tuberculosis L-aspartate α-decarboxylase. 
  • Chikungunya virus nsP3 & nsP4 interacts with HSP-90 to promote virus replication: HSP-90 inhibitors reduce CHIKV infection and inflammation in vivo. 
  • Chiral action at a distance: remote substituent effects on the optical activity of calyculins A and B. 
  • Chromatographic analysis and decomposition product characterization of compound SR16157 (NSC 732011). 
  • Chronic hypergastrinemia: causes and consequences. 
  • Clinical dose ranging studies with finasteride, a type 2 5alpha-reductase inhibitor, in men with male pattern hair loss. 
  • Clinical evaluation of ZD6474, an orally active inhibitor of VEGF and EGF receptor signaling, in patients with solid, malignant tumors. 
  • Clinical isoflurane metabolism by cytochrome P450 2E1. 
  • Clinical research in pancreatic cancer: the Radiation Therapy Oncology Group trials. 
  • Cloning and characterization of PDE7B, a cAMP-specific phosphodiesterase. 
  • Cloning and characterization of a mammalian lithium-sensitive bisphosphate 3'-nucleotidase inhibited by inositol 1,4-bisphosphate. 
  • Co-operative signalling mechanisms required for erythroid precursor expansion in response to erythropoietin and stem cell factor. 
  • Cocaine increases dopamine release by mobilization of a synapsin-dependent reserve pool. 
  • Combination PI3K/MEK inhibition promotes tumor apoptosis and regression in PIK3CA wild-type, KRAS mutant colorectal cancer. 
  • Combination of low-dose flutamide and finasteride for PSA-only recurrent prostate cancer after primary therapy. 
  • Combined targeting of SET and tyrosine kinases provides an effective therapeutic approach in human T-cell acute lymphoblastic leukemia. 
  • Combined treatment with vessel dilator and kaliuretic hormone in persons with congestive heart failure. 
  • Comparative analysis of small molecules and histone substrate analogues as LSD1 lysine demethylase inhibitors. 
  • Comparison of in vitro activities of camptothecin and nitidine derivatives against fungal and cancer cells. 
  • Comparison of in vitro and in vivo inhibition potencies of fluvoxamine toward CYP2C19. 
  • Comparison of maltose and acarbose as inhibitors of maltase-glucoamylase activity in assaying acid alpha-glucosidase activity in dried blood spots for the diagnosis of infantile Pompe disease. 
  • Competitive inhibition of enzyme activity by urea. 
  • Complex response of breast epithelial cell lines to topoisomerase inhibitors. 
  • Computational design, synthesis and biological evaluation of para-quinone-based inhibitors for redox regulation of the dual-specificity phosphatase Cdc25B. 
  • Concentration-related effects of nitric oxide and endothelin-1 on human trabecular meshwork cell contractility. 
  • Concordance between trifluoroacetic acid and hepatic protein trifluoroacetylation after disulfiram inhibition of halothane metabolism in rats. 
  • Concurrent assessment of hepatic and intestinal cytochrome P450 3A activities using deuterated alfentanil. 
  • Conformation-assisted inhibition of protein-tyrosine phosphatase-1B elicits inhibitor selectivity over T-cell protein-tyrosine phosphatase. 
  • Consequences of inhibiting amyloid precursor protein processing enzymes on synaptic function and plasticity. 
  • Conservative management of morbidly adherent placenta: expert review. 
  • Constitutive and inducible Akt activity promotes resistance to chemotherapy, trastuzumab, or tamoxifen in breast cancer cells. 
  • Contemporary Management of Struvite Stones Using Combined Endourologic and Medical Treatment: Predictors of Unfavorable Clinical Outcome. 
  • Contribution of itraconazole metabolites to inhibition of CYP3A4 in vivo. 
  • Control of a biomolecular motor-powered nanodevice with an engineered chemical switch. 
  • Control of liver and brain aromatic amino-acid metabolism by phenylalanine hydroxylase. 
  • Controversies of renin-angiotensin system inhibition during the COVID-19 pandemic. 
  • Convergent translational evidence of a role for anandamide in amygdala-mediated fear extinction, threat processing and stress-reactivity 
  • Conversion of protein phosphatase 1 catalytic subunit to a Mn(2+)-dependent enzyme impairs its regulation by inhibitor 1. 
  • Coordinate regulation of forskolin-induced cellular proliferation in macrophages by protein kinase A/cAMP-response element-binding protein (CREB) and Epac1-Rap1 signaling: effects of silencing CREB gene expression on Akt activation. 
  • Critical role of FoxO3a in alcohol-induced autophagy and hepatotoxicity. 
  • Cryptococcus neoformans Ilv2p confers resistance to sulfometuron methyl and is required for survival at 37 degrees C and in vivo. 
  • Cryptococcus neoformans histone acetyltransferase Gcn5 regulates fungal adaptation to the host. 
  • Crystal structures of the active and alloxanthine-inhibited forms of xanthine dehydrogenase from Rhodobacter capsulatus. 
  • Crystal structures of the anticancer clinical candidates R115777 (Tipifarnib) and BMS-214662 complexed with protein farnesyltransferase suggest a mechanism of FTI selectivity. 
  • Crystallographic analysis reveals that anticancer clinical candidate L-778,123 inhibits protein farnesyltransferase and geranylgeranyltransferase-I by different binding modes. 
  • Curative Treatment of Severe Gram-Negative Bacterial Infections by a New Class of Antibiotics Targeting LpxC. 
  • Cyclic AMP mediated GSTP1 gene activation in tumor cells involves the interaction of activated CREB-1 with the GSTP1 CRE: a novel mechanism of cellular GSTP1 gene regulation. 
  • Cyclic mechanical stress and trabecular meshwork cell contractility. 
  • Cytosolic phospholipase A(2) activity associated with nuclei is not inhibited by arachidonyl trifluoromethyl ketone in macrophages stimulated with receptor-recognized forms of alpha(2)-macroglobulin. 
  • DNA repair protein O6-alkylguanine-DNA alkyltransferase is phosphorylated by two distinct and novel protein kinases in human brain tumour cells. 
  • DNA transfection of macaque and murine respiratory tissue is greatly enhanced by use of a nuclease inhibitor. 
  • Deactylase inhibitors disrupt cellular complexes containing protein phosphatases and deacetylases. 
  • Demethylation of H3K27 Is Essential for the Induction of Direct Cardiac Reprogramming by miR Combo. 
  • Dendritic cell transmigration through brain microvessel endothelium is regulated by MIP-1alpha chemokine and matrix metalloproteinases. 
  • Dependence of leucine-rich repeat kinase 2 (LRRK2) kinase activity on dimerization. 
  • Design and synthesis of novel imidazole-substituted dipeptide amides as potent and selective inhibitors of Candida albicans myristoylCoA:protein N-myristoyltransferase and identification of related tripeptide inhibitors with mechanism-based antifungal activity. 
  • Diacetyl induces amphiregulin shedding in pulmonary epithelial cells and in experimental bronchiolitis obliterans. 
  • Diatom gliding is the result of an actin-myosin motility system. 
  • Differential apoptosis-inducing effect of quercetin and its glycosides in human promyeloleukemic HL-60 cells by alternative activation of the caspase 3 cascade. 
  • Differential effects of prostaglandin E2-sensitive receptors on contractility of human ocular cells that regulate conventional outflow. 
  • Differential effects of prostate cancer therapeutics on neuroendocrine transdifferentiation. 
  • Differential mechanisms of morphine antinociceptive tolerance revealed in (beta)arrestin-2 knock-out mice. 
  • Difluoromethylornithine is a novel inhibitor of Helicobacter pylori growth, CagA translocation, and interleukin-8 induction. 
  • Diminished capacity for p53 in mediating a radiation-induced G1 arrest in established human tumor cell lines. 
  • Direct cloning of DNA sequences from the common fragile site region at chromosome band 3p14.2. 
  • Discovery and Optimization of a Porcupine Inhibitor. 
  • Discovery of geranylgeranyltransferase-I inhibitors with novel scaffolds by the means of quantitative structure-activity relationship modeling, virtual screening, and experimental validation. 
  • Discovery of novel bacterial elongation condensing enzyme inhibitors by virtual screening. 
  • Discovery of novel targets of quinoline drugs in the human purine binding proteome. 
  • Discovery of thiophene inhibitors of polo-like kinase. 
  • Disruption of dystroglycan-laminin interactions modulates water uptake by astrocytes. 
  • Distinct roles of matrix metalloproteases in the early- and late-phase development of neuropathic pain. 
  • Disulfiram is a direct and potent inhibitor of human O6-methylguanine-DNA methyltransferase (MGMT) in brain tumor cells and mouse brain and markedly increases the alkylating DNA damage. 
  • Does acid suppressive therapy reduce the risk of laryngeal cancer recurrence? 
  • Does ranolazine have a place in the treatment of acute coronary syndromes? 
  • Drug design from the cryptic inhibitor envelope. 
  • Durable Remissions with Ivosidenib in IDH1-Mutated Relapsed or Refractory AML. 
  • Duration of cytochrome P-450 2E1 (CYP2E1) inhibition and estimation of functional CYP2E1 enzyme half-life after single-dose disulfiram administration in humans. 
  • ERK MAP kinase activation in superficial spinal cord neurons induces prodynorphin and NK-1 upregulation and contributes to persistent inflammatory pain hypersensitivity. 
  • Effect of O6-benzylguanine on nitrogen mustard-induced toxicity, apoptosis, and mutagenicity in Chinese hamster ovary cells. 
  • Effect of a NOS inhibitor, L-NMMA, on the contractile function of reperfused skeletal muscle. 
  • Effect of cocaine on intracellular calcium regulation in myometrium from pregnant women. 
  • Effect of famoxadone on photoinduced electron transfer between the iron-sulfur center and cytochrome c1 in the cytochrome bc1 complex. 
  • Effect of genetic circular permutation near the active site on the activity and stability of an enzyme inhibitor. 
  • Effect of nitric oxide synthase inhibition on haemodynamics and outcome of patients with persistent cardiogenic shock complicating acute myocardial infarction: a phase II dose-ranging study. 
  • Effect of protein kinase C inhibitors and activators on corneal re-epithelialization in the rat. 
  • Effect of the isoflavone genistein against galactose-induced cataracts in rats. 
  • Effect of tilarginine acetate in patients with acute myocardial infarction and cardiogenic shock: the TRIUMPH randomized controlled trial. 
  • Effects of CoA-independent transacylase inhibitors on the production of lipid inflammatory mediators. 
  • Effects of Y27632 on keratinocyte procurement and wound healing. 
  • Effects of a novel arginine methyltransferase inhibitor on T-helper cell cytokine production. 
  • Effects of arginase isoforms on NO Production by nNOS. 
  • Effects of cardiotonic steroids on trabecular meshwork cells: search for mediator of ouabain-enhanced outflow facility. 
  • Effects of histone methyltransferase inhibition in endometriosis. 
  • Effects of kaliuretic peptide on sodium and water excretion in persons with congestive heart failure. 
  • Effects of pharmacologic inhibition of protein geranylgeranyltransferase type I on aqueous humor outflow through the trabecular meshwork. 
  • Effects of quercetin on magnesium-dependent adenosine triphosphatase and the metabolism of human polymorphonuclear leukocytes. 
  • Effects of striatal nitric oxide production on regional cerebral blood flow and seizure development in rats exposed to extreme hyperoxia. 
  • Efficacy and pharmacokinetic/pharmacodynamic evaluation of the Aurora kinase A inhibitor MLN8237 against preclinical models of pediatric cancer. 
  • Efficacy and tolerability of finasteride 1 mg in men aged 41 to 60 years with male pattern hair loss. 
  • Efficacy of finasteride 1 mg in the treatment of androgenetic alopecia in men. 
  • Egr-1 is activated by 17beta-estradiol in MCF-7 cells by mitogen-activated protein kinase-dependent phosphorylation of ELK-1. 
  • Electric fields and MAP kinase signaling can regulate early wound healing in lens epithelium. 
  • Electrical stimulation of neonatal cardiac myocytes activates the NFAT3 and GATA4 pathways and up-regulates the adenylosuccinate synthetase 1 gene. 
  • Eliglustat maintains long-term clinical stability in patients with Gaucher disease type 1 stabilized on enzyme therapy. 
  • Emerging therapies in hepatitis C: dawn of the era of the direct-acting antivirals. 
  • Emodin induces apoptosis in human promyeloleukemic HL-60 cells accompanied by activation of caspase 3 cascade but independent of reactive oxygen species production. 
  • Enantiomeric metabolic interactions and stereoselective human methadone metabolism. 
  • Endocrine therapy in metastatic breast cancer. 
  • Endothelial cell surface F1-F0 ATP synthase is active in ATP synthesis and is inhibited by angiostatin. 
  • Endotoxin-mediated nitric oxide synthesis inhibits IL-1beta gene transcription in ANA-1 murine macrophages. 
  • Endotoxin-mediated synthesis of nitric oxide is dependent on Gq protein signal transduction. 
  • Engineering of glycerol-stimulated insulin secretion in islet beta cells. Differential metabolic fates of glucose and glycerol provide insight into mechanisms of stimulus-secretion coupling. 
  • Enhanced Electrical Field Stimulated Nitrergic and Purinergic Vasoreactivity in Distal vs Proximal Internal Pudendal Arteries. 
  • Enhancement of irinotecan (CPT-11) activity against central nervous system tumor xenografts by alkylating agents. 
  • Enhancement of melphalan activity by inhibition of DNA polymerase-alpha and DNA polymerase-beta. 
  • Enteroviruses infect human enteroids and induce antiviral signaling in a cell lineage-specific manner. 
  • Epac1-induced cellular proliferation in prostate cancer cells is mediated by B-Raf/ERK and mTOR signaling cascades. 
  • Epidermal growth factor receptor expression and signaling are essential in glutamine's cytoprotective mechanism in heat-stressed intestinal epithelial-6 cells. 
  • Epidermal growth factor receptor trans-activation mediates the tonic and fibrogenic effects of endothelin in the aortic wall of transgenic mice. 
  • Essential role of AT1A receptor in the development of 2K1C hypertension. 
  • Estrogen excess associated with novel gain-of-function mutations affecting the aromatase gene. 
  • Estrogen production and metabolism in endometriosis. 
  • Estrogen protects against intracranial aneurysm rupture in ovariectomized mice. 
  • Evidence for fumonisin inhibition of ceramide synthase in humans consuming maize-based foods and living in high exposure communities in Guatemala. 
  • Evidence for metabolism of fluoromethyl 2,2-difluoro-1-(trifluoromethyl)vinyl ether (compound A), a sevoflurane degradation product, by cysteine conjugate beta-lyase. 
  • Evidence that polyphenols do not inhibit the phospholipid scramblase TMEM16F. 
  • Evolutionarily conserved role of calcineurin in phosphodegron-dependent degradation of phosphodiesterase 4D. 
  • Evolved resistance to partial GAPDH inhibition results in loss of the Warburg effect and in a different state of glycolysis. 
  • Exogenous PP2A inhibitor exacerbates the progression of nonalcoholic fatty liver disease via NOX2-dependent activation of miR21. 
  • Expanded safety analysis of pevonedistat, a first-in-class NEDD8-activating enzyme inhibitor, in patients with acute myeloid leukemia and myelodysplastic syndromes. 
  • Experimental inhibition of porcupine-mediated Wnt O-acylation attenuates kidney fibrosis. 
  • Exposure to naturally circulating androgens during foetal life incurs direct reproductive costs in female spotted hyenas, but is prerequisite for male mating. 
  • Expression of a beta-adrenergic receptor kinase 1 inhibitor prevents the development of myocardial failure in gene-targeted mice. 
  • Expression of a peptide inhibitor of protein phosphatase 1 increases phosphorylation and activity of CREB in NIH 3T3 fibroblasts. 
  • Expression of nonphagocytic NADPH oxidase system in the ocular lens. 
  • Expression of p27 in residual rectal cancer after preoperative chemoradiation predicts long-term outcome. 
  • Expression signatures of the lipid-based Akt inhibitors phosphatidylinositol ether lipid analogues in NSCLC cells. 
  • Extracellular release of ATP mediated by cyclic mechanical stress leads to mobilization of AA in trabecular meshwork cells. 
  • Extracellular signal-regulated kinase plays an essential role in hypertrophic agonists, endothelin-1 and phenylephrine-induced cardiomyocyte hypertrophy. 
  • Extrapolation of Adult Efficacy Data to Pediatric Systemic Lupus Erythematosus: Evaluating Similarities in Exposure-Response. 
  • FOXO transcription factors control E2F1 transcriptional specificity and apoptotic function. 
  • Facile synthesis of substituted trans-2-arylcyclopropylamine inhibitors of the human histone demethylase LSD1 and monoamine oxidases A and B. 
  • Farnesyltransferase inhibitors alter the prenylation and growth-stimulating function of RhoB. 
  • Fasnall, a Selective FASN Inhibitor, Shows Potent Anti-tumor Activity in the MMTV-Neu Model of HER2(+) Breast Cancer. 
  • Fasudil decreases lesion burden in a murine model of cerebral cavernous malformation disease. 
  • Fatty acid synthase inhibition engages a novel caspase-2 regulatory mechanism to induce ovarian cancer cell death. 
  • Fatty acid synthesis is essential for survival of Cryptococcus neoformans and a potential fungicidal target. 
  • Feedback regulation of beta-arrestin1 function by extracellular signal-regulated kinases. 
  • Female pattern hair loss. 
  • Fibronectin-integrin signaling is required for L-glutamine's protection against gut injury. 
  • Finasteride in the treatment of men with androgenetic alopecia. Finasteride Male Pattern Hair Loss Study Group. 
  • Fluctuation-driven directional flow in biochemical cycle: further study of electric activation of Na,K pumps. 
  • Fluvoxamine-theophylline interaction: gap between in vitro and in vivo inhibition constants toward cytochrome P4501A2. 
  • Forskolin stimulation of water and cation permeability in aquaporin 1 water channels. 
  • Frequent engagement of the classical and alternative NF-kappaB pathways by diverse genetic abnormalities in multiple myeloma. 
  • Frontal fibrosing alopecia: a retrospective review of 19 patients seen at Duke University. 
  • Fumonisin B1 alters sphingolipid metabolism and disrupts the barrier function of endothelial cells in culture. 
  • Fumonisin toxicity and sphingolipid biosynthesis. 
  • Fumonisins and fumonisin analogs as inhibitors of ceramide synthase and inducers of apoptosis. 
  • Function of nuclear factor kappaB in pancreatic cancer metastasis. 
  • Functionalized indoleamines as potent, drug-like inhibitors of isoprenylcysteine carboxyl methyltransferase (Icmt). 
  • Future trends in managing hepatitis C. 
  • G protein beta gamma subunits stimulate phosphorylation of Shc adapter protein. 
  • G protein-coupled receptor internalization signaling is required for cardioprotection in ischemic preconditioning. 
  • GPR54 is a target for suppression of metastasis in endometrial cancer. 
  • GTP cyclohydrolase and tetrahydrobiopterin regulate pain sensitivity and persistence. 
  • Gamma-L-glutaminyl-3,4-benzoquinone. Structural studies and enzymatic synthesis. 
  • Gating of CaMKII by cAMP-regulated protein phosphatase activity during LTP. 
  • Genetic and biochemical studies establish that the fungicidal effect of a fully depeptidized inhibitor of Cryptococcus neoformans myristoyl-CoA:protein N-myristoyltransferase (Nmt) is Nmt-dependent. 
  • Genetic and pharmacologic analyses of the role of Icmt in Ras membrane association and function. 
  • Genetic and pharmacologic identification of Akt as a mediator of brain-derived neurotrophic factor/TrkB rescue of neuroblastoma cells from chemotherapy-induced cell death. 
  • Genetically determined P2X7 receptor pore formation regulates variability in chronic pain sensitivity. 
  • Geographic variations in the use of medical and surgical therapies for benign prostatic hyperplasia. 
  • GlcNAc-1-P-transferase-tunicamycin complex structure reveals basis for inhibition of N-glycosylation. 
  • Glucocorticoid metabolism in proximal tubules modulates angiotensin II-induced electrolyte transport. 
  • Glucose metabolism as a target of histone deacetylase inhibitors. 
  • Growth arrest and DNA damage-inducible protein GADD34 targets protein phosphatase 1 alpha to the endoplasmic reticulum and promotes dephosphorylation of the alpha subunit of eukaryotic translation initiation factor 2. 
  • Growth factor induced activation of Rho and Rac GTPases and actin cytoskeletal reorganization in human lens epithelial cells. 
  • Growth hormone regulates phosphorylation and function of CCAAT/enhancer-binding protein beta by modulating Akt and glycogen synthase kinase-3. 
  • HEPATIC ALDEHYDE OXIDASE. 3. THE SUBSTRATE-BINDING SITE. 
  • HIV-1 gp120 induces anergy in naive T lymphocytes through CD4-independent protein kinase-A-mediated signaling. 
  • Haptotactic gradients for directed cell migration: stimulation and inhibition using soluble factors. 
  • Heme oxygenase-1 is upregulated in the kidney of angiotensin II-induced hypertensive rats : possible role in renoprotection. 
  • Heterotopic ossification in rectal cancer: Rare finding with a novel proposed mechanism. 
  • High affinity for farnesyltransferase and alternative prenylation contribute individually to K-Ras4B resistance to farnesyltransferase inhibitors. 
  • High frequency of aberrant p16(INK4A) expression in human breast cancer. 
  • High levels of glucose stimulate angiotensinogen gene expression via the P38 mitogen-activated protein kinase pathway in rat kidney proximal tubular cells. 
  • High susceptibility of MDR and XDR Gram-negative pathogens to biphenyl-diacetylene-based difluoromethyl-allo-threonyl-hydroxamate LpxC inhibitors. 
  • High-affinity inhibitors of dihydrofolate reductase: antimicrobial and anticancer activities of 7,8-dialkyl-1,3-diaminopyrrolo[3,2-f]quinazolines with small molecular size. 
  • High-dose, single-agent irinotecan as first-line therapy in the treatment of metastatic colorectal cancer. 
  • High-performance liquid chromatographic analysis for a non-chromophore-containing phosphatidyl inositol analog, 1-((1-O-octadecyl-2-O-methyl-sn-glycero)phospho)-1D-3-deoxy-myo-inositol, using indirect UV detection. 
  • Highly substituted terphenyls as inhibitors of parasite cGMP-dependent protein kinase activity. 
  • Hippocampal long-term potentiation is normal in heme oxygenase-2 mutant mice. 
  • Histone H3 lysine 4 demethylation is a target of nonselective antidepressive medications. 
  • Histone acetylation in keratinocytes enables control of the expression of cathelicidin and CD14 by 1,25-dihydroxyvitamin D3. 
  • Histone deacetylase 3 binds to and regulates the GCMa transcription factor. 
  • Histone deacetylase inhibitor panobinostat induces clinical responses with associated alterations in gene expression profiles in cutaneous T-cell lymphoma. 
  • Hormone refractory prostate cancer: Management and advances. 
  • Human CD34+ hematopoietic progenitors have low, cytokine-unresponsive O6-alkylguanine-DNA alkyltransferase and are sensitive to O6-benzylguanine plus BCNU. 
  • Human enteric microsomal CYP4F enzymes O-demethylate the antiparasitic prodrug pafuramidine. 
  • Human halothane metabolism, lipid peroxidation, and cytochromes P(450)2A6 and P(450)3A4. 
  • Hydrolyzed fumonisins HFB1 and HFB2 are acylated in vitro and in vivo by ceramide synthase to form cytotoxic N-acyl-metabolites. 
  • Hyperbaric oxygen reduces cerebral blood flow by inactivating nitric oxide. 
  • Hyperpolarization induces a long-term increase in the spontaneous firing rate of cerebellar Golgi cells. 
  • Hypersecretion of mucin in response to inflammatory mediators by guinea pig tracheal epithelial cells in vitro is blocked by inhibition of nitric oxide synthase. 
  • Hyposmotically activated chloride channels in cultured rabbit non-pigmented ciliary epithelial cells. 
  • IKKβ promotes metabolic adaptation to glutamine deprivation via phosphorylation and inhibition of PFKFB3. 
  • Identification and biochemical studies on novel non-nucleoside inhibitors of the enzyme adenosine kinase. 
  • Identification of a Novel Inhibitor of Human Rhinovirus Replication and Inflammation in Airway Epithelial Cells. 
  • Identification of a glutathione S-transferase without affinity for glutathione sepharose in human kidney. 
  • Identification of a new family of protein phosphatase 2A regulatory subunits. 
  • Identification of chemical inhibitors to human tissue transglutaminase by screening existing drug libraries. 
  • Identification of highly potent and selective Cdc25 protein phosphatases inhibitors from miniaturization click-chemistry-based combinatorial libraries. 
  • Immunotoxin FN18-CRM9 induces stronger T cell signaling than unconjugated monoclonal antibody FN18. 
  • Implication of mitochondrial involvement in apoptotic activity of fragile histidine triad gene: application of synchronous luminescence spectroscopy. 
  • Importance of the beta12-beta13 loop in protein phosphatase-1 catalytic subunit for inhibition by toxins and mammalian protein inhibitors. 
  • Importance of the stress kinase p38alpha in mediating the direct cytotoxic effects of the thalidomide analogue, CPS49, in cancer cells and endothelial cells. 
  • Improved loading and cleavage methods for solid-phase synthesis using chlorotrityl resins: synthesis and testing of a library of 144 discrete chemicals as potential farnesyltransferase inhibitors. 
  • In vitro biological activity of a novel small-molecule inhibitor of polo-like kinase 1. 
  • In vitro hepatic metabolism explains higher clearance of voriconazole in children versus adults: role of CYP2C19 and flavin-containing monooxygenase 3. 
  • In vivo and in vitro inhibition of CYP1A-dependent activity in Fundulus heteroclitus by the polynuclear aromatic hydrocarbon fluoranthene. 
  • Inactivation of 4-oxalocrotonate tautomerase by 2-oxo-3-pentynoate. 
  • Increased ileal proglucagon expression after jejunectomy is not suppressed by inhibition of bowel growth. 
  • Increased renal dopamine and acute renal adaptation to a high-phosphate diet. 
  • Independent beta-arrestin 2 and G protein-mediated pathways for angiotensin II activation of extracellular signal-regulated kinases 1 and 2. 
  • Induction of apoptotic cell death and prevention of tumor growth by ceramide analogues in metastatic human colon cancer. 
  • Induction of cyclooxygenase-2 synthesis by ligation of the macrophage alpha(2)-macroglobulin signalling receptor. 
  • Induction of hepatic CYP1A in channel catfish increases binding of 2-aminoanthracene to DNA in vitro and in vivo. 
  • Induction of nitric oxide in cultured microglia: evidence for a cytoprotective role. 
  • Influence of group B streptococci on piglet pulmonary artery response to bradykinin. 
  • Influence of metal ions on substrate binding and catalytic activity of mammalian protein geranylgeranyltransferase type-I. 
  • Inhibiting the inhibitor: targeting vascular endothelial protein tyrosine phosphatase to promote tumor vascular maturation. 
  • Inhibiting the palmitoylation/depalmitoylation cycle selectively reduces the growth of hematopoietic cells expressing oncogenic Nras. 
  • Inhibition of CYP1A1 enzyme activity in mouse hepatoma cell culture by soybean isoflavones. 
  • Inhibition of Human Dendritic Cell ER Stress Response Reduces T Cell Alloreactivity Yet Spares Donor Anti-tumor Immunity. 
  • Inhibition of Isoprenylcysteine Carboxylmethyltransferase Induces Cell-Cycle Arrest and Apoptosis through p21 and p21-Regulated BNIP3 Induction in Pancreatic Cancer. 
  • Inhibition of LRRK2 kinase activity promotes anterograde axonal transport and presynaptic targeting of α-synuclein. 
  • Inhibition of NF-kappa B by S-nitrosylation. 
  • Inhibition of Rho-kinase induces alphaB-crystallin expression in lens epithelial cells. 
  • Inhibition of aldehyde dehydrogenase expands hematopoietic stem cells with radioprotective capacity. 
  • Inhibition of de novo ceramide synthesis reverses diet-induced insulin resistance and enhances whole-body oxygen consumption. 
  • Inhibition of human immunodeficiency virus type 1 transcription by chemical cyclin-dependent kinase inhibitors. 
  • Inhibition of iNOS attenuates skeletal muscle reperfusion injury in extracellular superoxide dismutase knockout mice. 
  • Inhibition of iNOS with 1400W improves contractile function and alters nos gene and protein expression in reperfused skeletal muscle. 
  • Inhibition of isoprenylcysteine carboxylmethyltransferase induces autophagic-dependent apoptosis and impairs tumor growth. 
  • Inhibition of mitogen-activated protein kinase and phosphatidylinositol 3-kinase activity in MCF-7 cells prevents estrogen-induced mitogenesis. 
  • Inhibition of nitric oxide synthase on brain oxygenation in anesthetized rats exposed to hyperbaric oxygen. 
  • Inhibition of notch signaling induces neural differentiation in Ewing sarcoma. 
  • Inhibition of receptor-localized PI3K preserves cardiac beta-adrenergic receptor function and ameliorates pressure overload heart failure. 
  • Inhibition of sarco(endo)plasmic reticulum Ca2+-ATPase differentially regulates contractile function in cardiac myocytes from normotensive and spontaneously hypertensive rats: role of Ca2+ regulatory proteins. 
  • Inhibition of sphingosine kinase 2 downregulates the expression of c-Myc and Mcl-1 and induces apoptosis in multiple myeloma. 
  • Inhibition of the Staphylococcus aureus sortase transpeptidase SrtA by phosphinic peptidomimetics. 
  • Inhibition of the gut enzyme intestinal alkaline phosphatase may explain how aspartame promotes glucose intolerance and obesity in mice. 
  • Inhibition of vascular smooth muscle cell proliferation, migration, and survival by the tumor suppressor protein PTEN. 
  • Inhibitor binding increases the mechanical stability of staphylococcal nuclease. 
  • Inhibitor-1 interaction domain that mediates the inhibition of protein phosphatase-1. 
  • Inhibitor-1, a regulator of protein phosphatase 1 function. 
  • Inhibitors of prostaglandin synthesis inhibit human prostate tumor cell invasiveness and reduce the release of matrix metalloproteinases. 
  • Initial testing (stage 1) of the PARP inhibitor BMN 673 by the pediatric preclinical testing program: PALB2 mutation predicts exceptional in vivo response to BMN 673. 
  • Insight into the mechanism of inactivation of ribonucleotide reductase by gemcitabine 5'-diphosphate in the presence or absence of reductant. 
  • Insulin inhibits angiotensinogen gene expression via the mitogen-activated protein kinase pathway in rat kidney proximal tubular cells. 
  • Insulin-like growth factor-1 but not growth hormone augments mammalian myocardial contractility by sensitizing the myofilament to Ca2+ through a wortmannin-sensitive pathway: studies in rat and ferret isolated muscles. 
  • Integrating diagnostics and therapeutics: revolutionizing drug discovery and patient care. 
  • Interleukin 10 is induced by recombinant HIV-1 Nef protein involving the calcium/calmodulin-dependent phosphodiesterase signal transduction pathway. 
  • Interleukin-1, tumor necrosis factor alpha, and interleukin-17 synergistically up-regulate nitric oxide and prostaglandin E2 production in explants of human osteoarthritic knee menisci. 
  • Interleukin-1beta elevates cyclooxygenase-2 protein level and enzyme activity via increasing its mRNA stability in human endometrial stromal cells: an effect mediated by extracellularly regulated kinases 1 and 2. 
  • Interleukin-3-induced activation of the JAK/STAT pathway is prolonged by proteasome inhibitors. 
  • Intracellular innate immune cascades and interferon defenses that control hepatitis C virus. 
  • Intracellular trafficking of histone deacetylase 4 regulates neuronal cell death. 
  • Intralysosomal iron induces lysosomal membrane permeabilization and cathepsin D-mediated cell death in trabecular meshwork cells exposed to oxidative stress. 
  • Intravenous Migraine Treatment in Children and Adolescents. 
  • Intravenous allopurinol decreases myocardial oxygen consumption and increases mechanical efficiency in dogs with pacing-induced heart failure. 
  • Involvement of a cytosine side chain in proton transfer in the rate-determining step of ribozyme self-cleavage. 
  • Involvement of cAMP-dependent protein kinase in mu-opioid modulation of NMDA-mediated synaptic currents. 
  • Involvement of the MKK6-p38gamma cascade in gamma-radiation-induced cell cycle arrest. 
  • Involvement of the checkpoint protein Mec1p in silencing of gene expression at telomeres in Saccharomyces cerevisiae. 
  • Irinotecan treatment for recurrent malignant glioma using an every-3-week regimen. 
  • Irinotecan: promising activity in the treatment of malignant glioma. 
  • Isolation and characterization of a protein from rat testis which inhibits cyclic AMP-dependent protein kinase and phosdiesterase. 
  • Isolation and regulation of the protein kinase inhibitor and the calcium-dependent cyclic nucleotide phosphodiesterase regulator in the Sertoli cell-enriched testis. 
  • Isolation from the mushroom Agaricus bisporus and chemical synthesis of gamma-L-glutaminyl-4-hydroxybenzene. 
  • Isolation of an active fragment of protein phosphatase inhibitor-I from rabbit skeletal muscle. 
  • Isolation, structure and biological activities of platensimycin B4 from Streptomyces platensis. 
  • Isolation, structure, and HIV-1-integrase inhibitory activity of structurally diverse fungal metabolites. 
  • Isoprenylcysteine carboxylmethyltransferase regulates mitochondrial respiration and cancer cell metabolism. 
  • JAK2 inhibition prevents innate immune responses and rescues animals from sepsis. 
  • JNK-induced MCP-1 production in spinal cord astrocytes contributes to central sensitization and neuropathic pain. 
  • Joint acute toxicity of esfenvalerate and diazinon to larval fathead minnows (Pimephales promelas). 
  • Juglone, an inhibitor of the peptidyl-prolyl isomerase Pin1, also directly blocks transcription. 
  • KDM1 class flavin-dependent protein lysine demethylases. 
  • Lack of effect of topical finasteride suggests an endocrine role for dihydrotestosterone. 
  • Lack of efficacy of finasteride in postmenopausal women with androgenetic alopecia. 
  • Lack of single-dose disulfiram effects on cytochrome P-450 2C9, 2C19, 2D6, and 3A4 activities: evidence for specificity toward P-450 2E1. 
  • Lactate uptake contributes to the NAD(P)H biphasic response and tissue oxygen response during synaptic stimulation in area CA1 of rat hippocampal slices. 
  • Letrozole in the treatment of breast cancer. 
  • Ligation of the alpha2M signalling receptor elevates the levels of p21Ras-GTP in macrophages. 
  • Local encoding of computationally designed enzyme activity. 
  • Lonafarnib for cancer and progeria. 
  • Long-lasting CNS effects of a short-term chemical knockout of ornithine decarboxylase during development: nicotinic cholinergic receptor upregulation and subtle macromolecular changes in adulthood. 
  • Loss of PTEN/MMAC1/TEP in EGF receptor-expressing tumor cells counteracts the antitumor action of EGFR tyrosine kinase inhibitors. 
  • Loss of RB and MTS1/CDKN2 (p16) expression in human sarcomas. 
  • Loss of phosphatase and tensin homologue increases transforming growth factor beta-mediated invasion with enhanced SMAD3 transcriptional activity. 
  • Lung-specific induction of heme oxygenase-1 and hyperoxic lung injury. 
  • Lysine-specific histone demethylase 1 inhibitors control breast cancer proliferation in ERα-dependent and -independent manners. 
  • Lysophosphatidic acid receptor signaling in mammalian retinal pigment epithelial cells. 
  • MAP kinase phosphorylation-dependent activation of Elk-1 leads to activation of the co-activator p300. 
  • MDM2-dependent inhibition of p53 is required for Epstein-Barr virus B-cell growth transformation and infected-cell survival. 
  • Macrophage tumor killing: influence of the local environment. 
  • Mammalian target of rapamycin inhibition. 
  • Management of adverse events associated with idelalisib treatment: expert panel opinion. 
  • Matrix metalloproteinase inhibition of pancreatic cancer: matching mechanism of action to clinical trial design. 
  • Mature macrophage cell lines exhibit variable responses to LPS. 
  • Mechanical stress and nitric oxide influence leukotriene production in cartilage. 
  • Mechanism of action of nalidixic acid: purification of Escherichia coli nalA gene product and its relationship to DNA gyrase and a novel nicking-closing enzyme. 
  • Mechanism of regulation of casein kinase I activity by group I metabotropic glutamate receptors. 
  • Mechanism of time-dependent inhibition of 5 alpha-reductases by delta 1-4-azasteroids: toward perfection of rates of time-dependent inhibition by using ligand-binding energies. 
  • Mechanisms associated with tumor vascular shut-down induced by combretastatin A-4 phosphate: intravital microscopy and measurement of vascular permeability. 
  • Mechanisms of excessive estrogen formation in endometriosis. 
  • Mechanisms of ischemic injury are different in the steatotic and normal rat liver. 
  • Mechanisms of nonimmunological histamine and tryptase release from human cutaneous mast cells. 
  • Metabolic efficiency with ranolazine for less ischemia in non-ST elevation acute coronary syndromes (MERLIN TIMI-36) study. 
  • Metabolism of alfentanil by cytochrome p4503a (cyp3a) enzymes. 
  • Metabolism of levo-alpha-Acetylmethadol (LAAM) by human liver cytochrome P450: involvement of CYP3A4 characterized by atypical kinetics with two binding sites. 
  • Metabolism of levulinate in perfused rat livers and live rats: conversion to the drug of abuse 4-hydroxypentanoate. 
  • Metabolism of methadone and levo-alpha-acetylmethadol (LAAM) by human intestinal cytochrome P450 3A4 (CYP3A4): potential contribution of intestinal metabolism to presystemic clearance and bioactivation. 
  • Metabolomics and mass isotopomer analysis as a strategy for pathway discovery: pyrrolyl and cyclopentenyl derivatives of the pro-drug of abuse, levulinate. 
  • Metallothionein alleviates glutathione depletion-induced oxidative cardiomyopathy in murine hearts. 
  • Methyltransferase inhibitors restore SATB1 protective activity against cutaneous T cell lymphoma in mice. 
  • Minoxidil inhibits ocular cell proliferation and lysyl hydroxylase activity. 
  • Mitigation of pennyroyal oil hepatotoxicity in the mouse. 
  • Mitochondrial DNA damage as a potential biomarker of LRRK2 kinase activity in LRRK2 Parkinson's disease. 
  • Mitogen-activated protein kinases as potential targets for pain killers. 
  • Mitotic phosphatase activity is required for MCC maintenance during the spindle checkpoint. 
  • Modulation of IA currents by capsaicin in rat trigeminal ganglion neurons. 
  • Modulation of aqueous humor outflow facility by the Rho kinase-specific inhibitor Y-27632. 
  • Modulation of estrogen receptor levels in mouse uterus by protein kinase C isoenzymes. 
  • Molecular cloning and characterization of a distinct human phosphodiesterase gene family: PDE11A. 
  • Molecular cloning of ILP-2, a novel member of the inhibitor of apoptosis protein family. 
  • Molecular cloning of protein phosphatase inhibitor-1 and its expression in rat and rabbit tissues. 
  • Molecular determinants of nuclear protein phosphatase-1 regulation by NIPP-1. 
  • Molecular mechanisms of glucose action on angiotensinogen gene expression in rat proximal tubular cells. 
  • Molecular or pharmacologic perturbation of the link between glucose and lipid metabolism is without effect on glucose-stimulated insulin secretion. A re-evaluation of the long-chain acyl-CoA hypothesis. 
  • Multicenter phase II study of a 28-day regimen of orally administered eniluracil and fluorouracil in the treatment of patients with anthracycline- and taxane-resistant advanced breast cancer. 
  • Multiple interactions within the AKAP220 signaling complex contribute to protein phosphatase 1 regulation. 
  • Multiple pathways of rapid beta 2-adrenergic receptor desensitization. Delineation with specific inhibitors. 
  • Multiple polyamine regulatory pathways control compensatory cardiovascular hypertrophy in coarctation hypertension. 
  • Multiple structural elements define the specificity of recombinant human inhibitor-1 as a protein phosphatase-1 inhibitor. 
  • Mutant epidermal growth factor receptor up-regulates molecular effectors of tumor invasion. 
  • Mutations of the bacteriophage T4 type II DNA topoisomerase that alter sensitivity to antitumor agent 4'-(9-acridinylamino)methanesulfon-m-anisidide and an antibacterial quinolone. 
  • My hair is thinning on the top of my head. What treatments are available for hair loss in women? 
  • Myocardial G protein-coupled receptor kinases: implications for heart failure therapy. 
  • Myogenic constriction of human coronary arterioles. 
  • NAAG peptidase inhibition reduces locomotor activity and some stereotypes in the PCP model of schizophrenia via group II mGluR. 
  • NAD(P)H quinone oxidoreductase 1 is essential for ozone-induced oxidative stress in mice and humans. 
  • NADPH oxidase promotes NF-kappaB activation and proliferation in human airway smooth muscle. 
  • NFκB-mediated CXCL1 production in spinal cord astrocytes contributes to the maintenance of bone cancer pain in mice. 
  • Naive human T cells are activated and proliferate in response to the heme oxygenase-1 inhibitor tin mesoporphyrin. 
  • Neoadjuvant comparisons of aromatase inhibitors and tamoxifen: pretreatment determinants of response and on-treatment effect. 
  • Neonatal infection-induced memory impairment after lipopolysaccharide in adulthood is prevented via caspase-1 inhibition. 
  • Neonatal polyamine depletion by alpha-difluoromethylornithine: effects on adenylyl cyclase cell signaling are separable from effects on brain region growth. 
  • Nerve activity-dependent modulation of calcineurin signaling in adult fast and slow skeletal muscle fibers. 
  • Neuregulin-1 enhances depolarization-induced GABA release. 
  • Neurokinin-1 receptor enhances TRPV1 activity in primary sensory neurons via PKCepsilon: a novel pathway for heat hyperalgesia. 
  • Neurotrophin-3 mediates the autocrine survival of the catecholaminergic CAD CNS neuronal cell line. 
  • New fungal metabolite geranylgeranyltransferase inhibitors with antifungal activity. 
  • New member of the trefoil factor family of proteins is an alpha-macroglobulin protease inhibitor. 
  • Nicotinamide Phosphoribosyltransferase Attenuates Methotrexate Response in Juvenile Idiopathic Arthritis and In Vitro. 
  • Nitric oxide contributes to cerebrovascular shear-mediated dilatation but not steady-state cerebrovascular reactivity to carbon dioxide. 
  • Nitric oxide donors protect murine myocardium against infarction via modulation of mitochondrial permeability transition. 
  • Nitric oxide is fundamental to neurovascular coupling in humans. 
  • Nitric oxide is necessary for CC-class chemokine expression in endotoxin-stimulated ANA-1 murine macrophages. 
  • Nitric oxide modulates branching morphogenesis in fetal rat lung explants. 
  • Nitric oxide production and regulation of neuronal NOS in tyrosine hydroxylase containing neurons. 
  • Nitric oxide synthase inhibitors decrease coronary sinus-free radical concentration and ameliorate myocardial stunning in an ischemia-reperfusion model. 
  • Nociceptors are interleukin-1beta sensors. 
  • Notch promotes radioresistance of glioma stem cells. 
  • Notch signaling maintains Leydig progenitor cells in the mouse testis. 
  • Novel PI analogues selectively block activation of the pro-survival serine/threonine kinase Akt. 
  • Novel antiangiogenic therapies for renal cell cancer. 
  • Novel biologically active nonpeptidic inhibitors of myristoylCoA:protein N-myristoyltransferase. 
  • Novel role of the nociceptin system as a regulator of glutamate transporter expression in developing astrocytes. 
  • Novel therapeutic approaches to advanced prostate cancer. 
  • Nuclear deformation during breast cancer cell transmigration. 
  • Nucleo-cytoplasmic interactions that control nuclear envelope breakdown and entry into mitosis in the sea urchin zygote. 
  • Nucleotide excision repair functions in the removal of chromium-induced DNA damage in mammalian cells. 
  • Numerical simulations of ethacrynic acid transport from precorneal region to trabecular meshwork. 
  • O6-benzylguanine-mediated enhancement of chemotherapy. 
  • O6-benzylguanine-mediated enhancement of nitrosourea activity in Mer- central nervous system tumor xenografts--implications for clinical trials. 
  • Okadaic acid disrupts synaptic vesicle trafficking in a ribbon-type synapse. 
  • Oncogenic KRAS is dependent upon an EFR3A-PI4KA signaling axis for potent tumorigenic activity. 
  • Oncogenic PIK3CA mutations reprogram glutamine metabolism in colorectal cancer. 
  • Oral poly(ADP-ribose) polymerase-1 inhibitor BSI-401 has antitumor activity and synergizes with oxaliplatin against pancreatic cancer, preventing acute neurotoxicity. 
  • Overexpression of the cardiac beta(2)-adrenergic receptor and expression of a beta-adrenergic receptor kinase-1 (betaARK1) inhibitor both increase myocardial contractility but have differential effects on susceptibility to ischemic injury. 
  • Overview consensus statement. Newer approaches to androgen deprivation therapy in prostate cancer. 
  • Oxidant-mediated Akt activation in human RPE cells. 
  • PAK1 mediates resistance to PI3K inhibition in lymphomas. 
  • PI3K inhibitors block skeletogenesis but not patterning in sea urchin embryos. 
  • PTEN status mediates 2ME2 anti-tumor efficacy in preclinical glioblastoma models: role of HIF1α suppression. 
  • Pan-caspase inhibitor VX-166 reduces fibrosis in an animal model of nonalcoholic steatohepatitis. 
  • Paradoxical role of cytochrome P450 3A in the bioactivation and clinical effects of levo-alpha-acetylmethadol: importance of clinical investigations to validate in vitro drug metabolism studies. 
  • Parathyroid hormone inhibits renal phosphate transport by phosphorylation of serine 77 of sodium-hydrogen exchanger regulatory factor-1. 
  • Pathophysiology of hypercortisolism in depression: pituitary and adrenal responses to low glucocorticoid feedback. 
  • Pentosan polysulfate decreases prostate smooth muscle proliferation and extracellular matrix turnover. 
  • Pentostatin (2'-deoxycoformycin) in the treatment of cutaneous T-cell lymphoma. 
  • Perifosine as a potential novel anti-telomerase therapy. 
  • Persistent expression of human clotting factor IX from mouse liver after intravenous injection of adeno-associated virus vectors. 
  • Perturbation of Staphylococcus aureus gene expression by the enoyl-acyl carrier protein reductase inhibitor AFN-1252. 
  • Pevonedistat (MLN4924), a First-in-Class NEDD8-activating enzyme inhibitor, in patients with acute myeloid leukaemia and myelodysplastic syndromes: a phase 1 study. 
  • Pevonedistat, a first-in-class NEDD8-activating enzyme inhibitor, combined with azacitidine in patients with AML. 
  • Pharmacokinetics and bioequivalence of a combined oral formulation of eniluracil, an inactivator of dihydropyrimidine dehydrogenase, and 5-fluorouracil in patients with advanced solid malignancies. 
  • Pharmacologic disruption of Polycomb-repressive complex 2-mediated gene repression selectively induces apoptosis in cancer cells. 
  • Pharmacological and surgical treatments for obesity. 
  • Phase 2 study of sodium phenylbutyrate in ALS. 
  • Phase I Study of Seviteronel, a Selective CYP17 Lyase and Androgen Receptor Inhibitor, in Men with Castration-Resistant Prostate Cancer. 
  • Phase I and pharmacokinetic study of 3'-C-ethynylcytidine (TAS-106), an inhibitor of RNA polymerase I, II and III,in patients with advanced solid malignancies. 
  • Phase I and pharmacokinetic study of lonafarnib, SCH 66336, using a 2-week on, 2-week off schedule in patients with advanced solid tumors. 
  • Phase I study of the farnesyltransferase inhibitor lonafarnib with weekly paclitaxel in patients with solid tumors. 
  • Phase I trial of O6-benzylguanine for patients undergoing surgery for malignant glioma. 
  • Phase I trial of single-dose temozolomide and continuous administration of o6-benzylguanine in children with brain tumors: a pediatric brain tumor consortium report. 
  • Phase I trial of weekly MK-0752 in children with refractory central nervous system malignancies: a pediatric brain tumor consortium study. 
  • Phase II study of oral eniluracil, 5-fluorouracil, and leucovorin in patients with advanced colorectal carcinoma. 
  • Phase II study of the farnesyltransferase inhibitor R115777 in advanced melanoma (CALGB 500104). 
  • Phase II trial of 5-fluorouracil plus eniluracil in patients with advanced pancreatic cancer: a Southwest Oncology Group study. 
  • Phase II trial of ZD1694 (Tomudex) in patients with advanced pancreatic cancer. 
  • Phase II trial of gefitinib in recurrent glioblastoma. 
  • Phenotypes of trypsin- and collagenase-prepared bovine corneal endothelial cells in the presence of a selective Rho kinase inhibitor, Y-27632. 
  • Phosphatidylinositol 3-kinase activates ERK in primary sensory neurons and mediates inflammatory heat hyperalgesia through TRPV1 sensitization. 
  • Phosphatidylinositol 3-kinase is an early intermediate in the G beta gamma-mediated mitogen-activated protein kinase signaling pathway. 
  • Phosphorus-based SAHA analogues as histone deacetylase inhibitors. 
  • Phosphorylation of eukaryotic translation initiation factor 4G1 (eIF4G1) by protein kinase C{alpha} regulates eIF4G1 binding to Mnk1. 
  • Phosphorylation of phosphatase inhibitor-2 at centrosomes during mitosis. 
  • Physiologic importance of protein phosphatase inhibitors. 
  • Platelet-derived growth factor receptors: a therapeutic target in solid tumors. 
  • Polyribonucleotides induce nitric oxide production by human monocyte-derived macrophages. 
  • Post-transcriptional inhibition of lipopolysaccharide-induced expression of inducible nitric oxide synthase by Gö6976 in murine microglia. 
  • Postsynaptic requirement for Abl kinases in assembly of the neuromuscular junction. 
  • Potentiation of CD3-induced expression of the linker for activation of T cells (LAT) by the calcineurin inhibitors cyclosporin A and FK506. 
  • Potentiation of calcium levels by extracellular arachidonic acid in nuclei isolated from macrophages stimulated with receptor-recognized forms of alpha(2)-macroglobulin. 
  • Potentiation of paclitaxel cytotoxicity in lung and esophageal cancer cells by pharmacologic inhibition of the phosphoinositide 3-kinase/protein kinase B (Akt)-mediated signaling pathway. 
  • Preclinical and clinical pharmacodynamic assessment of L-778,123, a dual inhibitor of farnesyl:protein transferase and geranylgeranyl:protein transferase type-I. 
  • Preferential inhibition of Akt and killing of Akt-dependent cancer cells by rationally designed phosphatidylinositol ether lipid analogues. 
  • Probing of the cis-5-phenyl proline scaffold as a platform for the synthesis of mechanism-based inhibitors of the Staphylococcus aureus sortase SrtA isoform. 
  • Progressive neuronal activation accompanies epileptogenesis caused by hippocampal glutamine synthetase inhibition. 
  • Proinflammatory actions of thromboxane receptors to enhance cellular immune responses. 
  • Promoter methylation and silencing of the tissue factor pathway inhibitor-2 (TFPI-2), a gene encoding an inhibitor of matrix metalloproteinases in human glioma cells. 
  • Protease activity of normal and PHA stimulated human lymphocytes. 
  • Protein (serine and threonine) phosphate phosphatases. 
  • Protein Geranylgeranyltransferase Type 1 as a Target in Cancer. 
  • Protein kinase C and Ca2+ activation of mucin secretion in airway goblet cells. 
  • Protein kinase C inhibition abrogates hepatic ischemic preconditioning responses. 
  • Protein kinase C mediates potentiation of synaptic transmission by phorbol ester at parallel fibers in the dorsal cochlear nucleus. 
  • Protein kinase C modulates estrogen receptors in differentiated osteoblastic cells in vitro. 
  • Protein kinase CK2 phosphorylates the cell cycle regulatory protein Geminin. 
  • Protein kinase activity and identification of a toxic effector domain of the target of rapamycin TOR proteins in yeast. 
  • Protein kinase involved in lung injury susceptibility: evidence from enzyme isoform genetic knockout and in vivo inhibitor treatment. 
  • Protein phosphatase 1 regulation by inhibitors and targeting subunits. 
  • Protein phosphatase 2A activates the proapoptotic function of BAD in interleukin- 3-dependent lymphoid cells by a mechanism requiring 14-3-3 dissociation. 
  • Protein phosphatase 2A and its B56 regulatory subunit inhibit Wnt signaling in Xenopus. 
  • Protein phosphatase 2A dephosphorylation of phosphoserine 112 plays the gatekeeper role for BAD-mediated apoptosis. 
  • Protein phosphatase 2A inhibitors, I(1)(PP2A) and I(2)(PP2A), associate with and modify the substrate specificity of protein phosphatase 1. 
  • Protein phosphatase regulation by endogenous inhibitors. 
  • Protein phosphatases mediate depotentiation induced by high-intensity theta-burst stimulation. 
  • Protein prenylation: unique fats make their mark on biology. 
  • Protein prenyltransferases. 
  • Protein synthesis-dependent potentiation by thyroxine of antiviral activity of interferon-gamma. 
  • Protein tyrosine kinase and protein phosphatase signaling pathways regulate volume-sensitive chloride currents in a nonpigmented ciliary epithelial cell line. 
  • Psammaplin A as a general activator of cell-based signaling assays via HDAC inhibition and studies on some bromotyrosine derivatives. 
  • Purification of alpha-sarcin and an antifungal protein from Aspergillus giganteus by blue sepharose CL-6B affinity chromatography. 
  • Pyruvate dehydrogenase complex and nicotinamide nucleotide transhydrogenase constitute an energy-consuming redox circuit. 
  • Quantifying ceramide kinetics in vivo using stable isotope tracers and LC-MS/MS. 
  • Quantitative distinctions of active site molecular recognition by P-glycoprotein and cytochrome P450 3A4. 
  • Quantitative structure-activity relationship (QSAR) of indoloacetamides as inhibitors of human isoprenylcysteine carboxyl methyltransferase. 
  • Quinidine in the treatment of KCNT1-positive epilepsies. 
  • REV1 inhibitor JH-RE-06 enhances tumor cell response to chemotherapy by triggering senescence hallmarks. 
  • Radiolabeled inhibitors as probes for imaging mutant IDH1 expression in gliomas: Synthesis and preliminary evaluation of labeled butyl-phenyl sulfonamide analogs. 
  • Ranolazine-related dyspnea on exertion. 
  • Rapid, reversible modulation of blood-brain barrier P-glycoprotein transport activity by vascular endothelial growth factor. 
  • Rational Design of Selective Allosteric Inhibitors of PHGDH and Serine Synthesis with Anti-tumor Activity. 
  • Reactivation of Epstein-Barr Virus by HIF-1α Requires p53. 
  • Receptor-induced transient reduction in plasma membrane PtdIns(4,5)P2 concentration monitored in living cells. 
  • Reciprocal control of Forkhead box O 3a and c-Myc via the phosphatidylinositol 3-kinase pathway coordinately regulates p27Kip1 levels. 
  • Reciprocal regulation of angiotensin receptor-activated extracellular signal-regulated kinases by beta-arrestins 1 and 2. 
  • Recommendations for the use of eliglustat in the treatment of adults with Gaucher disease type 1 in the United States. 
  • Refined solution structure of the LpxC-TU-514 complex and pKa analysis of an active site histidine: insights into the mechanism and inhibitor design. 
  • Regression of atherosclerosis in monkeys reduces vascular superoxide levels. 
  • Regulation of M2-type pyruvate kinase mediated by the high-affinity IgE receptors is required for mast cell degranulation. 
  • Regulation of MMP-9 (type IV collagenase) production and invasiveness in gliomas by the extracellular signal-regulated kinase and jun amino-terminal kinase signaling cascades. 
  • Regulation of NFkappaB in hepatic ischemic preconditioning. 
  • Regulation of alpha-synuclein expression by poly (ADP ribose) polymerase-1 (PARP-1) binding to the NACP-Rep1 polymorphic site upstream of the SNCA gene. 
  • Regulation of casein kinase I epsilon and casein kinase I delta by an in vivo futile phosphorylation cycle. 
  • Regulation of cyclin D1/Cdk4 complexes by calcium/calmodulin-dependent protein kinase I. 
  • Regulation of cytosolic phospholipase A2 activity in macrophages stimulated with receptor-recognized forms of alpha 2-macroglobulin: role in mitogenesis and cell proliferation. 
  • Regulation of myosin light chain phosphorylation in the trabecular meshwork: role in aqueous humour outflow facility. 
  • Regulation of platelet-activating factor synthesis in human neutrophils by MAP kinases. 
  • Regulation of the brain's vascular responses to oxygen. 
  • Regulation of thromboxane receptor (TP) phosphorylation by protein phosphatase 1 (PP1) and PP2A. 
  • Relative contribution of preload and afterload to the reduction in cardiac output caused by nitric oxide synthase inhibition with L-N(G)-methylarginine hydrochloride 546C88. 
  • Release of DNA from dead and dying lymphocyte and monocyte cell lines in vitro. 
  • Releasing the block: setting differentiation free with mutant IDH inhibitors. 
  • Reperfusion injury is reduced in skeletal muscle by inhibition of inducible nitric oxide synthase. 
  • Reprogramming metabolic pathways in vivo with CRISPR/Cas9 genome editing to treat hereditary tyrosinaemia. 
  • Requirement of the prolyl isomerase Pin1 for the replication checkpoint. 
  • Resistance to dual blockade of the kinases PI3K and mTOR in KRAS-mutant colorectal cancer models results in combined sensitivity to inhibition of the receptor tyrosine kinase EGFR. 
  • Resistance to tyrosine kinase inhibition by mutant epidermal growth factor receptor variant III contributes to the neoplastic phenotype of glioblastoma multiforme. 
  • Resolving TRPV1- and TNF-α-mediated spinal cord synaptic plasticity and inflammatory pain with neuroprotectin D1. 
  • Responses to propofol in the pulmonary vascular bed of the rat. 
  • Rho GDP dissociation inhibitor-mediated disruption of Rho GTPase activity impairs lens fiber cell migration, elongation and survival. 
  • Rho GTPase/Rho kinase inhibition as a novel target for the treatment of glaucoma. 
  • Rho Kinase Inhibition Blunts Lesion Development and Hemorrhage in Murine Models of Aggressive Pdcd10/Ccm3 Disease. 
  • Rho kinase promotes alloimmune responses by regulating the proliferation and structure of T cells. 
  • Role of 14-3-3-mediated p38 mitogen-activated protein kinase inhibition in cardiac myocyte survival. 
  • Role of aromatase in endometrial disease. 
  • Role of calcium-independent phospholipase A(2)β in human pancreatic islet β-cell apoptosis. 
  • Role of cytochrome P4502B6 in methadone metabolism and clearance. 
  • Role of endocytosis in the activation of the extracellular signal-regulated kinase cascade by sequestering and nonsequestering G protein-coupled receptors. 
  • Role of farnesyltransferase in ABA regulation of guard cell anion channels and plant water loss. 
  • Role of leptin in fat regulation. 
  • Role of lysophospholipid growth factors in the modulation of aqueous humor outflow facility. 
  • Role of metabolic activation and the TRPA1 receptor in the sensory irritation response to styrene and naphthalene. 
  • Role of nitric oxide in vasodilation in upstream muscle during intermittent pneumatic compression. 
  • Role of phospholipase Cbeta3 phosphorylation in the desensitization of cellular responses to platelet-activating factor. 
  • Role of renal cysteine conjugate beta-lyase in the mechanism of compound A nephrotoxicity in rats. 
  • Role of the GLT-1 subtype of glutamate transporter in glutamate homeostasis: the GLT-1-preferring inhibitor WAY-855 produces marginal neurotoxicity in the rat hippocampus. 
  • Role of the renal cysteine conjugate beta-lyase pathway in inhaled compound A nephrotoxicity in rats. 
  • Role of vagus nerve in postprandial antropyloric coordination in conscious dogs. 
  • Roles for Fgf signaling during zebrafish fin regeneration. 
  • Roles of cytoplasmic Ca2+ and intracellular Ca2+ stores in induction and suppression of apoptosis in S49 cells. 
  • Ruboxistaurin, a protein kinase C beta inhibitor, as an emerging treatment for diabetes microvascular complications. 
  • Ruboxistaurin. 
  • S-nitrosoglutathione inhibits alpha1-adrenergic receptor-mediated vasoconstriction and ligand binding in pulmonary artery. 
  • STT4 is an essential phosphatidylinositol 4-kinase that is a target of wortmannin in Saccharomyces cerevisiae. 
  • SU5416 delays wound healing through inhibition of TGF-beta 1 activation. 
  • Second messenger systems in human gliomas. 
  • Selective activation and inhibition of calmodulin-dependent enzymes by a calmodulin-like protein found in human epithelial cells. 
  • Selective aromatase inhibition for patients with androgen-independent prostate carcinoma. 
  • Selective inhibition of JNK with a peptide inhibitor attenuates pain hypersensitivity and tumor growth in a mouse skin cancer pain model. 
  • Selective inhibition of matrix metalloproteinase-14 blocks tumor growth, invasion, and angiogenesis. 
  • Selective killing of cancer cells harboring mutant RAS by concomitant inhibition of NADPH oxidase and glutathione biosynthesis. 
  • Sensitivity of mature Erbb2 to geldanamycin is conferred by its kinase domain and is mediated by the chaperone protein Hsp90. 
  • Sequential doxorubicin and topotecan in relapsed/refractory aggressive non-Hodgkin's lymphoma: results of CALGB 59906. 
  • Serotonin 5-HT1A receptor-mediated Erk activation requires calcium/calmodulin-dependent receptor endocytosis. 
  • Sex-Dependent Glial Signaling in Pathological Pain: Distinct Roles of Spinal Microglia and Astrocytes. 
  • Signal transduction through substance P receptor in human glioblastoma cells: roles for Src and PKCdelta. 
  • Signal-transduction cascades as targets for therapeutic intervention by natural products. 
  • Signaling pathways utilized by PTH and dopamine to inhibit phosphate transport in mouse renal proximal tubule cells. 
  • Similarities and differences in the currents activated by capsaicin, piperine, and zingerone in rat trigeminal ganglion cells. 
  • Simtuzumab Is Ineffective for Patients With Bridging Fibrosis or Compensated Cirrhosis Caused by Nonalcoholic Steatohepatitis. 
  • Single-cell microarray enables high-throughput evaluation of DNA double-strand breaks and DNA repair inhibitors. 
  • Single-dose disulfiram does not inhibit CYP2A6 activity. 
  • Sirt2 Inhibition Enhances Metabolic Fitness and Effector Functions of Tumor-Reactive T Cells. 
  • Smac/Diablo antagonizes ubiquitin ligase activity of inhibitor of apoptosis proteins. 
  • Solution structure of DFF40 and DFF45 N-terminal domain complex and mutual chaperone activity of DFF40 and DFF45. 
  • Solving the Hydroxychloroquine Dosing Dilemma With a Smartphone App. 
  • Sonic hedgehog induces GLT-1 degradation via PKC delta to suppress its transporter activities. 
  • Sortase transpeptidases: insights into mechanism, substrate specificity, and inhibition. 
  • Spaced administration of PA32540 and clopidogrel results in greater platelet inhibition than synchronous administration of enteric-coated aspirin and enteric-coated omeprazole and clopidogrel. 
  • Species-specific and inhibitor-dependent conformations of LpxC: implications for antibiotic design. 
  • Specific agrin isoforms induce cAMP response element binding protein phosphorylation in hippocampal neurons. 
  • Specific inhibitors implicate a soluble metalloendoproteinase in exocytosis. 
  • Specificity determinants in phosphoinositide dephosphorylation: crystal structure of an archetypal inositol polyphosphate 5-phosphatase. 
  • Spectrum and subcellular determinants of fluorinated anesthetic-mediated proximal tubular injury. 
  • Sphingolipid metabolism: roles in signal transduction and disruption by fumonisins. 
  • Sphingolipids--the enigmatic lipid class: biochemistry, physiology, and pathophysiology. 
  • Spinal activation of protein kinase C elicits phrenic motor facilitation. 
  • Spinal injection of TNF-α-activated astrocytes produces persistent pain symptom mechanical allodynia by releasing monocyte chemoattractant protein-1. 
  • Src-mediated tyrosine phosphorylation of dynamin is required for beta2-adrenergic receptor internalization and mitogen-activated protein kinase signaling. 
  • Statin safety: an assessment using an administrative claims database. 
  • Statins inhibit toll-like receptor 4-mediated lipopolysaccharide signaling and cytokine expression. 
  • Stereochemical aspects of itraconazole metabolism in vitro and in vivo. 
  • Stimulation of Acanthamoeba actomyosin ATPase activity by myosin-II polymerization. 
  • Stimulation of thymocyte proliferation by phosphorothioate DNA oligonucleotides. 
  • Strain-dependent effects of environmental signals on the production of extracellular phospholipase by Cryptococcus neoformans. 
  • Stretch-induced nitric oxide modulates mechanical properties of skeletal muscle cells. 
  • Structural basis for binding and selectivity of antimalarial and anticancer ethylenediamine inhibitors to protein farnesyltransferase. 
  • Structural basis of small molecule ATPase inhibition of a human mitotic kinesin motor protein. 
  • Structure based design of a series of potent and selective non peptidic PTP-1B inhibitors. 
  • Structure of the LpxC deacetylase with a bound substrate-analog inhibitor. 
  • Structure of the deacetylase LpxC bound to the antibiotic CHIR-090: Time-dependent inhibition and specificity in ligand binding. 
  • Structure, inhibition, and regulation of essential lipid A enzymes. 
  • Structure- and Ligand-Dynamics-Based Design of Novel Antibiotics Targeting Lipid A Enzymes LpxC and LpxH in Gram-Negative Bacteria. 
  • Structure-Activity Relationship of Sulfonyl Piperazine LpxH Inhibitors Analyzed by an LpxE-Coupled Malachite Green Assay. 
  • Structure-guided DOT1L probe optimization by label-free ligand displacement. 
  • Sulfation of glycosaminoglycans depends on the catalytic activity of lithium-inhibited phosphatase BPNT2 in vitro. 
  • Synergic antiproliferative effect of DNA methyltransferase inhibitor in combination with anticancer drugs in gastric carcinoma. 
  • Syntheses, structures and antibiotic activities of LpxC inhibitors based on the diacetylene scaffold. 
  • Synthesis and activity of largazole analogues with linker and macrocycle modification 
  • Synthesis and evaluation of sulfonyl piperazine LpxH inhibitors. 
  • Synthesis of isomeric 3-piperidinyl and 3-pyrrolidinyl benzo[5,6]cyclohepta[1,2-b]pyridines: sulfonamido derivatives as inhibitors of Ras prenylation. 
  • System for expression of microsporidian methionine amino peptidase type 2 (MetAP2) in the yeast Saccharomyces cerevisiae. 
  • T cell activation up-regulates the expression of the focal adhesion kinase Pyk2: opposing roles for the activation of protein kinase C and the increase in intracellular Ca2+. 
  • TRPC6 expression in neurons is differentially regulated by NR2A- and NR2B-containing NMDA receptors. 
  • TRPV4 is necessary for trigeminal irritant pain and functions as a cellular formalin receptor. 
  • Tamoxifen pharmacogenomics: the role of CYP2D6 as a predictor of drug response. 
  • Targeted beta-adrenergic receptor kinase (betaARK1) inhibition by gene transfer in failing human hearts. 
  • Targeting EZH2 histone methyltransferase activity alleviates experimental intestinal inflammation. 
  • Targeting Hypoxia-Inducible Factor 1α in a New Orthotopic Model of Glioblastoma Recapitulating the Hypoxic Tumor Microenvironment. 
  • Targeting Isocitrate Dehydrogenase Mutations in Cancer: Emerging Evidence and Diverging Strategies. 
  • Targeting PDGF receptors in cancer--rationales and proof of concept clinical trials. 
  • Targeting Syk-activated B cells in murine and human chronic graft-versus-host disease. 
  • Targeting UDP-α-D-glucose 6-dehydrogenase inhibits glioblastoma growth and migration. 
  • Targeting methylguanine-DNA methyltransferase in the treatment of neuroblastoma. 
  • Targeting protein localization for anti-infective therapy. 
  • Targeting the hexosamine biosynthetic pathway and O-linked N-acetylglucosamine cycling for therapeutic and imaging capabilities in diffuse large B-cell lymphoma. 
  • Targeting the histone methyltransferase G9a activates imprinted genes and improves survival of a mouse model of Prader-Willi syndrome. 
  • Tau--an inhibitor of deacetylase HDAC6 function. 
  • Telomerase, cell immortality, and cancer. 
  • Tenellones A and B from a Diaporthe sp.: two highly substituted benzophenone inhibitors of parasite cGMP-dependent protein kinase activity. 
  • The Cryptococcus neoformans MAP kinase Mpk1 regulates cell integrity in response to antifungal drugs and loss of calcineurin function. 
  • The HDAC inhibitor SB939 overcomes resistance to BCR-ABL kinase Inhibitors conferred by the BIM deletion polymorphism in chronic myeloid leukemia. 
  • The IAP proteins: caspase inhibitors and beyond. 
  • The MEK pathway is required for stimulation of p21(WAF1/CIP1) by transforming growth factor-beta. 
  • The RAM1 gene encoding a protein-farnesyltransferase beta-subunit homologue is essential in Cryptococcus neoformans. 
  • The Soluble Guanylate Cyclase Stimulator IWP-953 Increases Conventional Outflow Facility in Mouse Eyes. 
  • The autonomous activity of calcium/calmodulin-dependent protein kinase IV is required for its role in transcription. 
  • The basis for K-Ras4B binding specificity to protein farnesyltransferase revealed by 2 A resolution ternary complex structures. 
  • The c-Jun N-terminal kinase 1 (JNK1) in spinal astrocytes is required for the maintenance of bilateral mechanical allodynia under a persistent inflammatory pain condition. 
  • The crystal structure of human protein farnesyltransferase reveals the basis for inhibition by CaaX tetrapeptides and their mimetics. 
  • The cyclophilin-like domain of Ran-binding protein-2 modulates selectively the activity of the ubiquitin-proteasome system and protein biogenesis. 
  • The cytoplasmic prolyl-tRNA synthetase of the malaria parasite is a dual-stage target of febrifugine and its analogs. 
  • The development of phosphatidylinositol ether lipid analogues as inhibitors of the serine/threonine kinase, Akt. 
  • The discovery of rofecoxib, [MK 966, Vioxx, 4-(4'-methylsulfonylphenyl)-3-phenyl-2(5H)-furanone], an orally active cyclooxygenase-2-inhibitor. 
  • The distal cytoplasmic domain of the erythropoietin receptor induces granulocytic differentiation in 32D cells. 
  • The effect of Rho-associated kinase inhibition on the ocular penetration of timolol maleate. 
  • The effects of N(omega)-propyl-L-arginine on reperfusion injury of skeletal muscle. 
  • The endothelial receptor tyrosine kinase Tie1 activates phosphatidylinositol 3-kinase and Akt to inhibit apoptosis. 
  • The expression of HMGB1 on microparticles from Jurkat and HL-60 cells undergoing apoptosis in vitro. 
  • The extracellular release of HMGB1 during apoptotic cell death. 
  • The farnesyl protein transferase inhibitor SCH66336 is a potent inhibitor of MDR1 product P-glycoprotein. 
  • The human oncoprotein and chromatin architectural factor DEK counteracts DNA replication stress. 
  • The in vitro reversal of histamine-induced vasodilation in the human internal mammary artery. 
  • The inhibition of the kynurenine pathway prevents behavioral disturbances and oxidative stress in the brain of adult rats subjected to an animal model of schizophrenia. 
  • The mutagen and carcinogen cadmium is a high-affinity inhibitor of the zinc-dependent MutLα endonuclease. 
  • The nitric oxide synthase inhibitor N(G)-nitro-L-arginine decreases defibrillation-induced free radical generation. 
  • The nitric oxide synthase inhibitor N(G)-nitro-L-arginine decreases defibrillation-induced free radical generation. 
  • The p16 status of tumor cell lines identifies small molecule inhibitors specific for cyclin-dependent kinase 4. 
  • The prostaglandin E2 EP1 receptor mediates pain perception and regulates blood pressure. 
  • The purinome, a complex mix of drug and toxicity targets. 
  • The quest for the "Holy Grail" of ischemic stroke cytoprotection: Statins may not be the answer. 
  • The release of microparticles by Jurkat leukemia T cells treated with staurosporine and related kinase inhibitors to induce apoptosis. 
  • The role of CYP1A inhibition in the embryotoxic interactions between hypoxia and polycyclic aromatic hydrocarbons (PAHs) and PAH mixtures in zebrafish (Danio rerio). 
  • The role of cAMP-dependent signaling in receptor-recognized forms of alpha 2-macroglobulin-induced cellular proliferation. 
  • The role of differential activation of p38-mitogen-activated protein kinase in preconditioned ventricular myocytes. 
  • The role of membrane lipids in the induction of macrophage apoptosis by microparticles. 
  • The role of protein kinase C in modulation of aqueous humor outflow facility. 
  • The role of the aryl hydrocarbon receptor pathway in mediating synergistic developmental toxicity of polycyclic aromatic hydrocarbons to zebrafish. 
  • The roles of 14-3-3 proteins in signal transduction. 
  • The structural basis for the selectivity of benzotriazole inhibitors of PTP1B. 
  • The therapeutic potential of a kallikrein inhibitor for treating hereditary angioedema. 
  • The use of acarbose inhibition in the measurement of acid alpha-glucosidase activity in blood lymphocytes for the diagnosis of Pompe disease. 
  • The viral oncoprotein E1A blocks transforming growth factor beta-mediated induction of p21/WAF1/Cip1 and p15/INK4B. 
  • Thematic review series: lipid posttranslational modifications. Structural biology of protein farnesyltransferase and geranylgeranyltransferase type I. 
  • Therapeutic activity of the topoisomerase I inhibitor J-107088 [6-N-(1-hydroxymethyla-2-hydroxyl) ethylamino-12,13-dihydro-13-(beta-D-glucopyranosyl) -5H-indolo[2,3-a]-pyrrolo[3,4-c]-carbazole-5,7(6H)-dione]] against pediatric and adult central nervous system tumor xenografts. 
  • Thrombospondin-1 mediates Rho-kinase inhibitor-induced increase in outflow-facility. 
  • Time-dependent inhibition of isoprenylcysteine carboxyl methyltransferase by indole-based small molecules. 
  • Tirapazamine: a hypoxia-activated topoisomerase II poison. 
  • Tissue-specific effects of chlorpyrifos on carboxylesterase and cholinesterase activity in adult rats: an in vitro and in vivo comparison. 
  • Topoisomerase I is essential in Cryptococcus neoformans: role In pathobiology and as an antifungal target. 
  • Topotecan for the treatment of recurrent or progressive central nervous system tumors - a pediatric oncology group phase II study. 
  • Topotecan is a potent inhibitor of SUMOylation in glioblastoma multiforme and alters both cellular replication and metabolic programming. 
  • Total synthesis and molecular target of largazole, a histone deacetylase inhibitor. 
  • Toxicity of oxidized low density lipoproteins for vascular smooth muscle cells and partial protection by antioxidants. 
  • Transient gamma-secretase inhibition accelerates and enhances fracture repair likely via Notch signaling modulation. 
  • Transient hypoxia stimulates mitochondrial biogenesis in brain subcortex by a neuronal nitric oxide synthase-dependent mechanism. 
  • Translating protein phosphatase research into treatments for neurodegenerative diseases. 
  • Transport properties of the calcium ionophore ETH-129. 
  • Traumatic brain injury-induced neuronal damage in the somatosensory cortex causes formation of rod-shaped microglia that promote astrogliosis and persistent neuroinflammation. 
  • Treatment of diabetic macular edema with an inhibitor of vascular endothelial-protein tyrosine phosphatase that activates Tie2. 
  • Trehalose pathway as an antifungal target. 
  • Two mammalian longevity assurance gene (LAG1) family members, trh1 and trh4, regulate dihydroceramide synthesis using different fatty acyl-CoA donors. 
  • Two-photon molecular excitation imaging of Ca2+ transients in Langendorff-perfused mouse hearts. 
  • Tyrosine kinase inhibitors in renal cell carcinoma. 
  • UDP acts as a growth factor for vascular smooth muscle cells by activation of P2Y(6) receptors. 
  • UV radiation is a transcriptional inducer of p21(Cip1/Waf1) cyclin-kinase inhibitor in a p53-independent manner. 
  • Unexpected effects of FERM domain mutations on catalytic activity of Jak3: structural implication for Janus kinases. 
  • Upregulation of spinal cannabinoid-1-receptors following nerve injury enhances the effects of Win 55,212-2 on neuropathic pain behaviors in rats. 
  • Upstream regulatory role for XIAP in receptor-mediated apoptosis. 
  • Urethral afferent nerve activity affects the micturition reflex; implication for the relationship between stress incontinence and detrusor instability. 
  • Uric acid level and allopurinol use as risk markers of mortality and morbidity in systolic heart failure. 
  • Uridine-based inhibitors as new leads for antibiotics targeting Escherichia coli LpxC. 
  • Urinary bladder organ hypertrophy is partially regulated by Akt1-mediated protein synthesis pathway. 
  • Use of integrative epigenetic and cytogenetic analyses to identify novel tumor-suppressor genes in malignant melanoma. 
  • Use of protein phosphatase inhibitors. 
  • Use of ranolazine in patients with incomplete revascularization after percutaneous coronary intervention: design and rationale of the Ranolazine for Incomplete Vessel Revascularization Post-Percutaneous Coronary Intervention (RIVER-PCI) trial. 
  • Use of sildenafil (Viagra) in patients with cardiovascular disease. Technology and Practice Executive Committee. 
  • VCP is essential for mitochondrial quality control by PINK1/Parkin and this function is impaired by VCP mutations. 
  • Vaccine-Mediated Inhibition of the Transporter Associated with Antigen Processing Is Insufficient To Induce Major Histocompatibility Complex E-Restricted CD8+ T Cells in Nonhuman Primates. 
  • Valproic acid without intensified antiviral therapy has limited impact on persistent HIV infection of resting CD4+ T cells. 
  • Vanadium-induced STAT-1 activation in lung myofibroblasts requires H2O2 and P38 MAP kinase. 
  • Variable apoptotic response of NSCLC cells to inhibition of the MEK/ERK pathway by small molecules or dominant negative mutants. 
  • Vascular endothelial growth factor receptor 2 controls blood pressure by regulating nitric oxide synthase expression. 
  • Vascular smooth muscle cell migration induced by domains of thrombospondin-1 is differentially regulated. 
  • Vinyl sulfones: inhibitors of SrtA, a transpeptidase required for cell wall protein anchoring and virulence in Staphylococcus aureus. 
  • XIAP as target for therapeutic apoptosis in prostate cancer. 
  • XIAP inhibition of caspase-3 preserves its association with the Apaf-1 apoptosome and prevents CD95- and Bax-induced apoptosis. 
  • XPO1/CRM1 Inhibition Causes Antitumor Effects by Mitochondrial Accumulation of eIF5A. 
  • Xanthine urolithiasis. 
  • alpha-Crystallin localizes to the leading edges of migrating lens epithelial cells. 
  • beta-Adrenergic activation of p38 MAP kinase in adipocytes: cAMP induction of the uncoupling protein 1 (UCP1) gene requires p38 MAP kinase. 
  • beta-Arrestin 2 expression determines the transcriptional response to lysophosphatidic acid stimulation in murine embryo fibroblasts. 
  • beta-Arrestin-mediated PDE4 cAMP phosphodiesterase recruitment regulates beta-adrenoceptor switching from Gs to Gi. 
  • c-Jun N-terminal kinase activation mediates downregulation of connexin43 in cardiomyocytes. 
  • cGMP-independent inotropic effects of nitric oxide and peroxynitrite donors: potential role for nitrosylation. 
  • p38 Mitogen-activated protein kinase mediates a negative inotropic effect in cardiac myocytes. 
  • p38 Mitogen-activated protein kinase plays a stimulatory role in hepatic gluconeogenesis. 
  • p38 mitogen-activated protein kinase is activated after a spinal nerve ligation in spinal cord microglia and dorsal root ganglion neurons and contributes to the generation of neuropathic pain. 
  • p38 mitogen-activated protein kinase is the central regulator of cyclic AMP-dependent transcription of the brown fat uncoupling protein 1 gene. 
  • p38 mitogen-activated protein kinase regulates growth factor-induced mitogenesis of rat pulmonary myofibroblasts. 
  • sCD44 overexpression increases intraocular pressure and aqueous outflow resistance. 
  • trans-2-Phenylcyclopropylamine is a mechanism-based inactivator of the histone demethylase LSD1. 
  • β-Arrestin-2-Dependent Signaling Promotes CCR4-mediated Chemotaxis of Murine T-Helper Type 2 Cells. 
  • β-Secretase (BACE1) inhibition causes retinal pathology by vascular dysregulation and accumulation of age pigment. 
• 

  Keywords of People

  • Alexander, John Hunter Peel, Professor of Medicine, Medicine, Cardiology
  • Berchuck, Andrew, James M. Ingram Distinguished Professor of Gynecologic Oncology, Obstetrics and Gynecology, Gynecologic Oncology
  • Choi, Steven Sok, Associate Professor of Medicine, Medicine, Gastroenterology
  • Guan, Ziqiang, Research Professor in Biochemistry, Biochemistry
  • McDonnell, Donald Patrick, Glaxo-Wellcome Distinguished Professor of Molecular Cancer Biology, in the School of Medicine, Cell Biology
  • McLendon, Roger Edwin, Professor of Pathology, Pathology
  • Milano, Carmelo Alessio, Joseph W. and Dorothy W. Beard Distinguished Professor of Experimental Surgery, Surgery, Cardiovascular and Thoracic Surgery
  • O'Connor, Christopher Michael, Adjunct Professor in the Department of Medicine, Medicine, Clinical Pharmacology
  • Preminger, Glenn Michael, James F. Glenn, M.D. Distinguished Professor of Urology, Surgery, Urology
  • Sampson, John Howard, Robert H., M.D. and Gloria Wilkins Professor of Neurosurgery, in the School of Medicine, Biomedical Engineering
  • Soderling, Scott Haydn, George Barth Geller Distinguished Professor of Molecular Biology, Cell Biology