Subject Areas on Research
- Metabolite gene regulation: imidazole and imidazole derivatives which circumvent cyclic adenosine 3',5'-monophosphate in induction of the Escherichia coli L-arabinose operon.
- Regulation of enzyme activity. The activity of enzymes can be controlled by a multiplicity of conformational equilibria.
- Structure-based redesign of corepressor specificity of the Escherichia coli purine repressor by substitution of residue 190.
- Suppression of the constitutive, male-specific rat hepatic cytochrome P-450 2c and its mRNA by 3,4,5,3',4',5'-hexachlorobiphenyl and 3-methylcholanthrene.
- Techniques for the study of the biochemical basis of drug action.
- The repression of hormone-activated PEPCK gene expression by glucose is insulin-independent but requires glucose metabolism.
- Transposed LEU2 gene of Saccharomyces cerevisiae is regulated normally.