Enzymes

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  Subject Areas on Research

  • "Parallel Iterative Reaction Path Optimization in ab initio Quantum Mechanical/Molecular Mechanical Modeling of Enzyme Reaction" 
  • A classification for genetic disorders of interest to orthopaedists. 
  • A comparsion of polyurethane and silastic artificial hearts in 10 long survival experiments in calves. 
  • A golden era for understanding enzyme mechanisms. 
  • A pseudobond parametrization for improved electrostatics in quantum mechanical/molecular mechanical simulations of enzymes. 
  • A robust and efficient method for estimating enzyme complex abundance and metabolic flux from expression data. 
  • A simple and enzyme-free method for processing infiltrating lymphocytes from small mouse tumors for ELISpot analysis. 
  • A structural perspective on the where, how, why, and what of nucleosome positioning. 
  • Acute, subacute, and residual effects of polychlorinated biphenyl (pcb) in rats. II. Pathology and electron microscopy of liver and serum enzyme study. 
  • Adapting the nudged elastic band method for determining minimum-energy paths of chemical reactions in enzymes. 
  • Advances in enzymology and related areas of molecular biology. Preface. 
  • An automated decision-tree approach to predicting protein interaction hot spots. 
  • Analyses of plasma for metabolic and hormonal changes in rats flown aboard COSMOS 2044. 
  • Assay and detection of the molybdenum cofactor. 
  • Beta-blockers alprenolol and carvedilol stimulate beta-arrestin-mediated EGFR transactivation. 
  • Biosensors and biochips: advances in biological and medical diagnostics. 
  • C-C bond forming radical SAM enzymes involved in the construction of carbon skeletons of cofactors and natural products. 
  • Compounds from silicones alter enzyme activity in curing barnacle glue and model enzymes. 
  • Computing van der Waals energies in the context of the rotamer approximation. 
  • Construction of new ligand binding sites in proteins of known structure. I. Computer-aided modeling of sites with pre-defined geometry. 
  • Controlled Protein Delivery Based on Enzyme-Responsive Nanocapsules 
  • Developmental pharmacogenomics. 
  • Distribution of lead-203 in human peripheral blood in vitro. 
  • Droplet-based pyrosequencing using digital microfluidics. 
  • ELEMENTARY STEPS IN ENZYME REACTIONS (AS STUDIED BY RELAXATION SPECTROMETRY). 
  • Early ribbon drawings of proteins. 
  • Effects of phenethyl isothiocyanate, a carcinogenesis inhibitor, on xenobiotic-metabolizing enzymes and nitrosamine metabolism in rats. 
  • Elucidating solvent contributions to solution reactions with ab initio QM/MM methods. 
  • Endocrine Screening Methods Workshop report: detection of estrogenic and androgenic hormonal and antihormonal activity for chemicals that act via receptor or steroidogenic enzyme mechanisms. 
  • Enzymatic polymerization of high molecular weight DNA amphiphiles that self-assemble into star-like micelles. 
  • Enzymatic studies in the different types of normal and leukemic human white cells. 
  • Enzymatic susceptibility and spontaneous release of human melanoma tumor-associated antigens. 
  • Enzyme elevation in patients with juvenile dermatomyositis and steroid myopathy. 
  • Enzyme-Responsive Delivery of Multiple Proteins with Spatiotemporal Control 
  • Enzyme-catalyzed synthesis of carbohydrates. 
  • Etomoxir-induced PPARalpha-modulated enzymes protect during acute renal failure. 
  • Free energies of chemical reactions in solution and in enzymes with ab initio quantum mechanics/molecular mechanics methods. 
  • Gene expression and survival changes in Saccharomyces cerevisiae during suspension culture. 
  • Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma. 
  • How do enzymes really work? 
  • Inhibitory proteins in the Newcastle disease virus-induced suppression of cell protein synthesis. 
  • Isolation and characterization of renal cortical membranes using an aqueous two-phase partition technique. 
  • Kinetics of allosteric enzymes. 
  • Linkage and association with type 1 diabetes on chromosome 1q42. 
  • Local adaptation across a climatic gradient despite small effective population size in the rare sapphire rockcress. 
  • MECHANISM OF ENZYME CATALYSIS. 
  • Mechanisms of resistance to oxidative and nitrosative stress: implications for fungal survival in mammalian hosts. 
  • Molecular mechanical properties of short-sequence peptide enzyme mimics. 
  • Multiple conformational changes in enzyme catalysis. 
  • Nine enzymes are required for assembly of the pacidamycin group of peptidyl nucleoside antibiotics. 
  • Nuclear quantum effects on an enzyme-catalyzed reaction with reaction path potential: proton transfer in triosephosphate isomerase. 
  • Optimality and robustness in quorum sensing (QS)-mediated regulation of a costly public good enzyme. 
  • Paradigm Shift for Radical S-Adenosyl-l-methionine Reactions: The Organometallic Intermediate Ω Is Central to Catalysis. 
  • Partial hepatectomy and bile duct ligation in rainbow trout (Oncorhynchus mykiss): histologic, immunohistochemical and enzyme histochemical characterization of hepatic regeneration and biliary hyperplasia. 
  • Periplasmic binding proteins: a versatile superfamily for protein engineering. 
  • Pharmacokinetic analysis of two-step approaches using bifunctional and enzyme-conjugated antibodies. 
  • Physiological and nutritional regulation of enzymes of triacylglycerol synthesis. 
  • Physiological implications of the presence, distribution, and regulation of calmodulin in eukaryotic cells. 
  • Predicting the clinical status of human breast cancer by using gene expression profiles. 
  • Probing the oligomeric structure of an enzyme by electrospray ionization time-of-flight mass spectrometry. 
  • Protein phosphorylation: hormones, drugs, and bioregulation. 
  • Quantum mechanics/molecular mechanics minimum free-energy path for accurate reaction energetics in solution and enzymes: sequential sampling and optimization on the potential of mean force surface. 
  • Radioenzymatic assay of platelet serotonin, dopamine and norepinephrine in subjects with normal and increased serotonin production. 
  • Rational design of nascent metalloenzymes. 
  • Reaction path determination for quantum mechanical/molecular mechanical modeling of enzyme reactions by combining first order and second order "chain-of-replicas" methods. 
  • Receptor biophysics and biochemistry. Enzymes. 
  • Receptor-selective coactivators as tools to define the biology of specific receptor-coactivator pairs. 
  • Relaxation spectra of enzymatic reactions. 
  • Robustness of MetaNet graph models: predicting control of urea production in humans. 
  • Sex-specific alterations in mRNA level of key lipid metabolism enzymes in skeletal muscle of overweight and obese subjects following endurance exercise. 
  • Simple biochemical pathways far from steady state can provide switchlike and integrated responses. 
  • Spectroscopic study of a DNA brush synthesized in situ by surface initiated enzymatic polymerization. 
  • Structure, inhibition, and regulation of essential lipid A enzymes. 
  • Structures involved in Tetrahymena rRNA self-splicing and RNA enzyme activity. 
  • The Arabidopsis epithiospecifier protein promotes the hydrolysis of glucosinolates to nitriles and influences Trichoplusia ni herbivory. 
  • The anatomy and taxonomy of protein structure. 
  • The biological significance of substrate inhibition: a mechanism with diverse functions. 
  • The cis-Pro touch-turn: a rare motif preferred at functional sites. 
  • The construction of metal centers in proteins by rational design. 
  • The evolution of control and distribution of adaptive mutations in a metabolic pathway 
  • Transcriptome analysis reveals novel patterning and pigmentation genes underlying Heliconius butterfly wing pattern variation. 
  • Transient kinetic approaches to enzyme mechanisms. 
  • Transscleral diffusion of ethacrynic acid and sodium fluorescein. 
  • Use of recombinant adenovirus for metabolic engineering of mammalian cells. 
  • [Activity of various enzyme systems after the administration of phenylbutazone (butazolidine)]. 
  • [Enzyme activity and hyperaminoacidemia arising in a case of essential hypoproteinemia]. 
  • [Hypoproteinemia and enzyme activity]. 
  • [THE ENZYMES OF THE LEUKOCYTE]. 
  • [Value of the determination of lactic dehydrase in the etiological diagnosis of serous effusions]. 
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  Keywords of People

  • Ferreira, Paulo Alexandre, Associate Professor in Ophthalmology, Pathology
  • Sullivan, Daniel Carl, Professor Emeritus of Radiology, Radiology