Epidemiologic Methods

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  Subject Areas on Research

  • A case-control method for assessing environmental risks from multiple industrial point sources. 
  • A case-only approach for assessing gene by sex interaction in human longevity. 
  • A cohort analysis of U.S. stomach cancer mortality 1950-1977. 
  • A comparison of respondent-driven and venue-based sampling of female sex workers in Liuzhou, China. 
  • A generalized estimating equation approach for modeling random length binary vector data. 
  • A large outbreak of foodborne salmonellosis on the Navajo Nation Indian Reservation, epidemiology and secondary transmission. 
  • A model for morbidity after lung resection in octogenarians. 
  • A new method for correcting under-estimation of disabled life expectancy and an application to the Chinese oldest-old. 
  • A pilot risk model for the prediction of rapid radiographic progression in rheumatoid arthritis. 
  • A review of the application of inflammatory biomarkers in epidemiologic cancer research. 
  • A smoker's paradox in patients hospitalized for heart failure: findings from OPTIMIZE-HF. 
  • A theoretical model of the physiological dynamics of circulatory disease in human populations. 
  • A two-disease model of female breast cancer: mortality in 1969 among white females in the United States. 
  • A variant of the LRP4 gene affects the risk of chronic lymphocytic leukaemia transformation to Richter syndrome. 
  • Acquisition of Clostridium difficile from the hospital environment. 
  • Addressing Extreme Propensity Scores via the Overlap Weights. 
  • Adjuvant versus salvage radiation therapy for prostate cancer and the risk of death. 
  • Air pollution and lung cancer mortality in Harris County, Texas, 1979-1981. 
  • Alcohol consumption and blood pressure in black adults: the Pitt County Study. 
  • Alzheimer's disease: a study of epidemiological aspects. 
  • An approach to conducting epidemiologic research within cooperative clinical trials groups. 
  • An outbreak of Shigella sonnei gastroenteritis on Colorado River raft trips. 
  • Approaches to monitoring biological outcomes for HPV vaccination: challenges of early adopter countries. 
  • Asbestos fibre dimensions and lung cancer mortality among workers exposed to chrysotile. 
  • Assessing the clinical effectiveness of preventive maneuvers: analytic principles and systematic methods in reviewing evidence and developing clinical practice recommendations. A report by the Canadian Task Force on the Periodic Health Examination. 
  • Assessment of myocardial infarction by cardiac magnetic resonance imaging and long-term mortality. 
  • Association of depression and survival in patients with chronic heart failure over 12 Years. 
  • Association of education with incidence of cognitive impairment in three established populations for epidemiologic studies of the elderly. 
  • Associations of major bleeding and myocardial infarction with the incidence and timing of mortality in patients presenting with non-ST-elevation acute coronary syndromes: a risk model from the ACUITY trial. 
  • Assortativity and Bias in Epidemiologic Studies of Contagious Outcomes: A Simulated Example in the Context of Vaccination. 
  • Atrial fibrillation management strategies and early mortality after myocardial infarction: results from the Valsartan in Acute Myocardial Infarction (VALIANT) Trial. 
  • Bayesian isotonic regression and trend analysis. 
  • Bayesian latent factor regression for functional and longitudinal data. 
  • Byssinosis: a disease or a symptom? 
  • Carcinomas in children. Clinical and demographic characteristics. 
  • Caries experience associated with attention-deficit/hyperactivity disorder. 
  • Changes in alkaline phosphatase levels in patients with prostate cancer receiving degarelix or leuprolide: results from a 12-month, comparative, phase III study. 
  • Changes in health status among participants of the Framingham Heart Study from the 1960s to the 1990s: application of an index of cumulative deficits. 
  • Childhood cancer and occupational radiation exposure in parents. 
  • Clear cell adenocarcinoma of the vagina and cervix: incidence, undetected disease, and diethylstilbestrol. 
  • Clinical and epidemiologic features of Rocky Mountain spotted fever in Mississippi, 1933-1973. 
  • Clinical data bases. Accomplishments and unrealized potential. 
  • Clinical features of depression in Asia: results of a large prospective, cross-sectional study. 
  • Clinical predictors of renal mass pathological features. 
  • Clinical, radiographic, molecular and MRI-based predictors of cartilage loss in knee osteoarthritis. 
  • Combined low-dose flutamide plus finasteride vs low-dose flutamide monotherapy for recurrent prostate cancer: a comparative analysis of two phase II trials with a long-term follow-up. 
  • Combining biological gene expression signatures in predicting outcome in breast cancer: An alternative to supervised classification. 
  • Commentary: Sir Arthur Mitchell--pioneer of psychiatric epidemiology and of community care. 
  • Comorbidity. 
  • Comparing Mammography Abnormality Features to Genetic Variants in the Prediction of Breast Cancer in Women Recommended for Breast Biopsy. 
  • Comparison of complication rates of porous anophthalmic orbital implants. 
  • Comparison of prostate-specific antigen recurrence-free survival in a contemporary cohort of patients undergoing either radical retropubic or robot-assisted laparoscopic radical prostatectomy. 
  • Compartment model approaches for estimating the parameters of a chronic disease process under changing risk factor exposures. 
  • Controversies in community-based psychiatric epidemiology: let the data speak for themselves. 
  • Coronary artery disease epidemic in Pakistan: more electrocardiographic evidence of ischaemia in women than in men. 
  • Cough in the community: a cross sectional survey and the relationship to gastrointestinal symptoms. 
  • Criteria for the use of Sartwell's incubation period model to study chronic diseases with uncertain etiology. 
  • Cross-trial comparisons in reviews: proceed with caution. 
  • Cultural concepts of distress and psychiatric disorders: literature review and research recommendations for global mental health epidemiology. 
  • Cutpoint selection for categorizing a continuous predictor. 
  • DNA adduct formation by 12 chemicals with populations potentially suitable for molecular epidemiological studies. 
  • Design and conduct of occupational epidemiology studies: I. Design aspects of cohort studies. 
  • Design and conduct of occupational epidemiology studies: II. Analysis of cohort data. 
  • Design and conduct of occupational epidemiology studies: III. Design aspects of case-control studies. 
  • Design and conduct of occupational epidemiology studies: IV. The analysis of case-control data. 
  • Design, methodological issues and participation in a multiple sclerosis case-control study. 
  • Development and longitudinal validation of the overall benefit of analgesia score: a simple multi-dimensional quality assessment instrument. 
  • Development and validation of a rapid assessment tool for malaria prevention. 
  • Developments in child psychiatric epidemiology. 
  • Diagnostic tests: understanding results, assessing utility, and predicting performance. 
  • Differences in urinary incontinence between Hispanic and non-Hispanic white women: a population-based study. 
  • Doubly robust estimation of causal effects. 
  • ESC Forum on Drug Eluting Stents European Heart House, Nice, 27-28 September 2007. 
  • Enhanced Recovery After Surgery (ERAS) for Spine Surgery: A Systematic Review. 
  • Epidemic Shiga bacillus dysentery in Central America. II. Epidemiologic studies in 1969. 
  • Epidemiological marker for oxidant status: comparison of the ELISA and the gas chromatography/mass spectrometry assay for urine 2,3-dinor-5,6-dihydro-15-F2t-isoprostane. 
  • Epidemiological modeling of acute mountain sickness (AMS). A prospective data collection standard. 
  • Epidemiologists, our patient is society. 
  • Erectile function after posterior urethroplasty for pelvic fracture-urethral distraction defect injuries. 
  • Established populations for epidemiologic studies of the elderly: study design and methodology. 
  • Estimating Survival in Patients With Lung Cancer and Brain Metastases: An Update of the Graded Prognostic Assessment for Lung Cancer Using Molecular Markers (Lung-molGPA). 
  • Estimating crude or common odds ratios in case-control studies with informatively missing exposure data. 
  • Estimating quality-adjusted life year losses associated with visual field deficits using methodological approaches. 
  • Estimating the occurrence of amyotrophic lateral sclerosis among Gulf War (1990-1991) veterans using capture-recapture methods. 
  • Ethnicity and gestational diabetes in New York City, 1995-2003. 
  • Evaluation metrics for biostatistical and epidemiological collaborations. 
  • Evidence-based therapy prescription in high-cardiovascular risk patients: the REACT study. 
  • Exposures and mortality among chrysotile asbestos workers. Part II: mortality. 
  • External validation of the SEARCH model for predicting aggressive recurrence after radical prostatectomy: results from the Duke Prostate Center Database. 
  • Familial aggregation of age-related macular degeneration in the Utah population. 
  • Familial aggregation of multiple myeloma and central nervous system diseases. 
  • Familial ovarian cancer: a population-based case-control study. 
  • Fluctuation of gastrointestinal symptoms in the community: a 10-year longitudinal follow-up study. 
  • Follow-up study of chrysotile textile workers: cohort mortality and exposure-response. 
  • Gender and heart disease. 
  • Genetic epidemiology of the susceptibility to leprosy. 
  • Genomic lesions associated with a different clinical outcome in diffuse large B-Cell lymphoma treated with R-CHOP-21. 
  • Head-to-head comparison of the Lyon Schuss and fixed flexion radiographic techniques. Long-term reproducibility in normal knees and sensitivity to change in osteoarthritic knees. 
  • High-intensity focused ultrasound for prostate cancer: comparative definitions of biochemical failure. 
  • Histone H4 acetylation by immunohistochemistry and prognosis in relapsed acute lymphocytic leukaemia (ALL). 
  • Human Gut Microbiota Predicts Susceptibility to Vibrio cholerae Infection. 
  • I Brazilian Registry of Heart Failure - Clinical Aspects, Care Quality and Hospitalization Outcomes. 
  • Identifying a national death index match. 
  • Impact of a medical journal club on house-staff reading habits, knowledge, and critical appraisal skills. A randomized control trial. 
  • Impact of diabetes on outcomes in patients with low and preserved ejection fraction heart failure: an analysis of the Candesartan in Heart failure: Assessment of Reduction in Mortality and morbidity (CHARM) programme. 
  • Impact of early surgery on survival of patients with severe mitral regurgitation. 
  • Implications of M bias in epidemiologic studies: a simulation study. 
  • Improving mental health practices in primary care: findings from recent research. 
  • Increased incidence of cervical and vaginal dysplasia in 3,980 diethylstilbestrol-exposed young women. Experience of the National Collaborative Diethylstilbestrol Adenosis Project. 
  • Industrial hygiene involvement in occupational epidemiology. 
  • Initial poor quality of life and new onset of dyspepsia: results from a longitudinal 10-year follow-up study. 
  • Injury history as a risk factor for incident injury in youth soccer. 
  • Interdependent effects of cohesion and concurrency for epidemic potential. 
  • Invited Commentary: Epidemiologic Methods as Applied to Epidemiology Education-Goals and Expectations to Advance and Diversify the Field. 
  • Isoniazid preventive therapy, HAART and tuberculosis risk in HIV-infected adults in South Africa: a prospective cohort. 
  • Karyotyping of Cryptococcus neoformans as an epidemiological tool. 
  • Knowledge and beliefs associated with refractive errors and undercorrection: the Singapore Malay Eye Study. 
  • Laboratory methods for assessing human semen in epidemiologic studies: a consensus report. 
  • Laparoscopic Approach in Colonic Diverticulitis: Dispelling Myths and Misperceptions. 
  • Learning from 2523 trauma deaths in India- opportunities to prevent in-hospital deaths. 
  • Long-term outcomes following microwave ablation for liver malignancies. 
  • Longitudinal change in clinical fracture incidence after initiation of bisphosphonates. 
  • Los Angeles student nurse study. Daily symptom reporting and photochemical oxidants. 
  • Male sex workers in Moscow, Russia: a pilot study of demographics, substance use patterns, and prevalence of HIV-1 and sexually transmitted infections. 
  • Melanoma reporting to central cancer registries by US dermatologists: an analysis of the persistent knowledge and practice gap. 
  • Meta-analysis of high- versus low-chloride content in perioperative and critical care fluid resuscitation. 
  • Methodological considerations in observational comparative effectiveness research for implantable medical devices: an epidemiologic perspective. 
  • Methodology of the Singapore Indian Chinese Cohort (SICC) eye study: quantifying ethnic variations in the epidemiology of eye diseases in Asians. 
  • Modeling disease incidence data with spatial and spatio temporal dirichlet process mixtures. 
  • Morbidity and mortality due to shigella and enterotoxigenic Escherichia coli diarrhoea: the Global Burden of Disease Study 1990-2016. 
  • Multiple imputation for missing data via sequential regression trees. 
  • Multiple myeloma and family history of cancer. A case-control study. 
  • Music meets surgery: two sides to the art of "healing". 
  • Nonparametric inference on median residual life function. 
  • Obese African-Americans with prostate cancer (T1c and a prostate-specific antigen, PSA, level of <10 ng/mL) have higher-risk pathological features and a greater risk of PSA recurrence than non-African-Americans. 
  • Obesity and oncological outcome after radical prostatectomy: impact of prostate-specific antigen-based prostate cancer screening: results from the Shared Equal Access Regional Cancer Hospital and Duke Prostate Center databases. 
  • Outcomes of medicare beneficiaries with heart failure and atrial fibrillation. 
  • Patterns of mortality and causes of death in polytrauma patients--has anything changed? 
  • Perceptions of weight discrimination: prevalence and comparison to race and gender discrimination in America. 
  • Population impact of mortality reduction: the effects of elimination of major causes of death on the 'saved' population. 
  • Post-myocardial infarction smoking cessation counseling: associations with immediate and late mortality in older Medicare patients. 
  • Powering Research through Innovative Methods for Mixtures in Epidemiology (PRIME) Program: Novel and Expanded Statistical Methods. 
  • Pre-operative homocysteine levels and morbidity and mortality following cardiac surgery. 
  • Predicting Outcomes Over Time in Patients With Heart Failure, Left Ventricular Systolic Dysfunction, or Both Following Acute Myocardial Infarction. 
  • Predicting freedom from clinical events in non-ST-elevation acute coronary syndromes: the Global Registry of Acute Coronary Events. 
  • Prediction of risk of death and myocardial infarction in the six months after presentation with acute coronary syndrome: prospective multinational observational study (GRACE). 
  • Prediction of subsequent ischemic heart disease using serial resting electrocardiograms. 
  • Prenatal diethylstilbestrol exposure and human genital tract abnormalities. 
  • Prevalence and prognostic implications of electrocardiographic left ventricular hypertrophy in heart failure: evidence from the CHARM programme. 
  • Primary ocular adnexal mucosa-associated lymphoid tissue lymphoma (MALT): single institution experience in a large cohort of patients. 
  • Projecting chronic disease prevalence. 
  • Propensity Score-Based Estimators With Multiple Error-Prone Covariates. 
  • Prospective study of incident injuries among southeastern United States commercial fishermen. 
  • Prostate cancer: a significant risk factor for late-life suicide. 
  • Prostate-specific antigen velocity based risk-adapted discontinuation of prostate cancer screening in elderly men. 
  • Protecting Confidentiality in Cancer Registry Data With Geographic Identifiers. 
  • Psychiatric diagnoses of medical service users: evidence from the Epidemiologic Catchment Area Program. 
  • Psychiatric disorders in adult children of alcoholics: data from the Epidemiologic Catchment Area project. 
  • Randomized controlled, multicentre clinical trial comparing a dual-probe ultrasonic lithotrite with a single-probe lithotrite for percutaneous nephrolithotomy. 
  • Rationale and methodology for a population-based study of eye diseases in Malay people: The Singapore Malay eye study (SiMES). 
  • Rationale, design, methodology, and baseline data of a population-based study in rural China: the Handan Eye Study. 
  • Re-calibration and external validation of an existing nomogram to predict aggressive recurrences after radical prostatectomy. 
  • Relation of prescription nonsteroidal antiinflammatory drug use to cognitive function among community-dwelling elderly. 
  • Relative impact of maternal depression and associated risk factors on offspring psychopathology. 
  • Renal impairment, worsening renal function, and outcome in patients with heart failure: an updated meta-analysis. 
  • Research Methods in Healthcare Epidemiology and Antimicrobial Stewardship-Mathematical Modeling. 
  • Research Methods in Healthcare Epidemiology and Antimicrobial Stewardship. 
  • Retinopathy of prematurity in the United States. 
  • Risk factors for estrogen receptor-positive breast cancer. 
  • Risk factors for nuclear, cortical and posterior subcapsular cataracts in the Chinese population of Singapore: the Tanjong Pagar Survey. 
  • Risk of smoking and receipt of cessation services among veterans with mental disorders. 
  • Risk stratification in ST-elevation myocardial infarction is enhanced by combining baseline ST deviation and subsequent ST-segment resolution. 
  • Risk stratification of serious adverse events after gastric bypass in the Bariatric Outcomes Longitudinal Database. 
  • Robot-assisted laparoscopic prostatectomy is not associated with early postoperative radiation therapy. 
  • Sensitivity and specificity of standardized screens of cognitive impairment and dementia among elderly black and white community residents. 
  • Sequential phase II Southwest Oncology Group studies (S0112 and S0301) of daunorubicin and cytarabine by continuous infusion, without and with ciclosporin, in older patients with previously untreated acute myeloid leukaemia. 
  • Shigellosis at sea: an outbreak aboard a passenger cruise ship. 
  • Short- and long-term outcomes following atrial fibrillation in patients with acute coronary syndromes with or without ST-segment elevation. 
  • Single-centre, triple-blinded, randomised, 1-year, parallel-group, superiority study to compare the effects of Roux-en-Y gastric bypass and sleeve gastrectomy on remission of type 2 diabetes and β-cell function in subjects with morbid obesity: a protocol for the Obesity surgery in Tønsberg (Oseberg) study. 
  • Social support and hypertension among blacks and whites in a rural, southern community. 
  • Social support and mortality in an elderly community population. 
  • Socioeconomic inequalities in oral health in childhood and adulthood in a birth cohort. 
  • Somatization disorder in the community. A study of diagnostic concordance among three diagnostic systems. 
  • Some features of the spread of epidemics and information on a random graph. 
  • Statistical methods for the time-to-event analysis of individual participant data from multiple epidemiological studies. 
  • Synthesis of environmental evidence: nitrogen dioxide epidemiology studies. 
  • Testing for contributions of mitochondrial DNA mutations to complex diseases. 
  • Testing homogeneity of two zero-inflated Poisson populations. 
  • The Aging, Demographics, and Memory Study: study design and methods. 
  • The Consortium of Metabolomics Studies (COMETS): Metabolomics in 47 Prospective Cohort Studies. 
  • The Gulf War Era Cohort and Biorepository: A Longitudinal Research Resource of Veterans of the 1990-1991 Gulf War Era. 
  • The NCDR ACTION Registry-GWTG: transforming contemporary acute myocardial infarction clinical care. 
  • The NIMH Epidemiologic Catchment Area program. Historical context, major objectives, and study population characteristics. 
  • The U.S. Food and Drug Administration's Mini-Sentinel program: status and direction. 
  • The contribution of hypertension to mortality in the US: 1968, 1977. 
  • The epidemiologic evidence for a relationship between social support and health. 
  • The epidemiology of psychiatric disorders in the elderly. 
  • The high prevalence of substance use disorders among recent MDMA users compared with other drug users: Implications for intervention. 
  • The impact of religious practice and religious coping on geriatric depression. 
  • The prevalence of and risk factors for pterygium in an urban Malay population: the Singapore Malay Eye Study (SiMES). 
  • The primary care physician and the psychiatric epidemiologist: a symbiotic service research partnership. 
  • The prognostic significance of heart rate in patients hospitalized for heart failure with reduced ejection fraction in sinus rhythm: insights from the EVEREST (Efficacy of Vasopressin Antagonism in Heart Failure: Outcome Study With Tolvaptan) trial. 
  • The relation of computer-based measures of sperm morphology and motility to male infertility. 
  • The use of mortality time series data to produce hypothetical morbidity distributions and projects mortality trends. 
  • Throw that epidemiologist out of the emergency room! Using the television series ER as a vehicle for teaching methodologists about medical issues. 
  • Trends in US suicide mortality rates 1968 to 1982: race and sex differences in age, period and cohort components. 
  • Trends in acute reperfusion therapy for ST-segment elevation myocardial infarction from 1999 to 2006: we are getting better but we have got a long way to go. 
  • Two-level stochastic search variable selection in GLMs with missing predictors. 
  • U.S. cancer mortality 1950-1978: a strategy for analyzing spatial and temporal patterns. 
  • Using epidemiologic survey data to plan geriatric mental health services. 
  • Weight loss and mortality risk in patients with chronic heart failure in the candesartan in heart failure: assessment of reduction in mortality and morbidity (CHARM) programme. 
  • What is a cohort effect? Comparison of three statistical methods for modeling cohort effects in obesity prevalence in the United States, 1971-2006. 
  • Who's crazy in Manhattan: a reexamination of "treatment of psychological disorders among urban children". 
  • Why those differences between the U..K. and the Belgian Heart Disease Prevention Project results? 
  • Working with visual display units. 
  • Workshop on fiber toxicology research needs. 
  • X-LRT: a likelihood approach to estimate genetic risks and test association with X-linked markers using a case-parents design. 
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  Keywords of People

  • Charles, Hal Cecil, Adjunct Associate Professor in the Department of Radiology, Radiology
  • Curtis, Lesley H., Professor in Population Health Sciences, Medicine, General Internal Medicine
  • Dement, John McCray, Professor Emeritus in Family Medicine and Community Health, Family Medicine & Community Health,Occupational & Environmental Medicine
  • Dunson, David B., Arts and Sciences Distinguished Professor of Statistical Science, Mathematics
  • Grambow, Steven C., Associate Professor of Biostatistics & Bioinformatics, Biostatistics & Bioinformatics
  • Merli, M. Giovanna, Professor in the Sanford School of Public Policy, Duke Global Health Institute
  • Muir, Kelly Walton, Associate Professor of Ophthalmology, Ophthalmology, Glaucoma
  • O'Connor, Christopher Michael, Richard Sean Stack, M.D. Distinguished Professor, Medicine, Clinical Pharmacology
  • Ostbye, Truls, Professor of Family Medicine and Community Health, Family Medicine and Community Health
  • Preminger, Glenn Michael, James F. Glenn, M.D. Distinguished Professor of Urology, Surgery, Urology
  • Stinnett, Sandra Sue, Associate Professor of Biostatistics & Bioinformatics, Biostatistics & Bioinformatics
  • Wu, Li-Tzy, Professor in Psychiatry and Behavioral Sciences, Medicine, General Internal Medicine