Epidemiologic Methods

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  Subject Areas on Research

  • A case-control method for assessing environmental risks from multiple industrial point sources. 
  • A case-control study of cancers of the nasal cavity and paranasal sinuses. 
  • A case-only approach for assessing gene by sex interaction in human longevity. 
  • A clinical and biochemical score for mortality prediction in patients with acute dyspnoea: derivation, validation and incorporation into a bedside programme. 
  • A cohort analysis of U.S. stomach cancer mortality 1950-1977. 
  • A comparison of respondent-driven and venue-based sampling of female sex workers in Liuzhou, China. 
  • A generalized estimating equation approach for modeling random length binary vector data. 
  • A large outbreak of foodborne salmonellosis on the Navajo Nation Indian Reservation, epidemiology and secondary transmission. 
  • A method for analyzing mortality data collected in follow-up studies. 
  • A model for morbidity after lung resection in octogenarians. 
  • A natural history of weight change in men with prostate cancer on androgen-deprivation therapy (ADT): results from the Shared Equal Access Regional Cancer Hospital (SEARCH) database. 
  • A new method for correcting under-estimation of disabled life expectancy and an application to the Chinese oldest-old. 
  • A pilot risk model for the prediction of rapid radiographic progression in rheumatoid arthritis. 
  • A possible artefactual component in specific cause mortality gradients. Social class variations in the clinical accuracy of death certificates. 
  • A review of the application of inflammatory biomarkers in epidemiologic cancer research. 
  • A smoker's paradox in patients hospitalized for heart failure: findings from OPTIMIZE-HF. 
  • A systematic review comparing antiretroviral adherence descriptive and intervention studies conducted in the USA. 
  • A theoretical model of the physiological dynamics of circulatory disease in human populations. 
  • A three-decade review of thermal injuries among the elderly at a regional burn centre. 
  • A two-disease model of female breast cancer: mortality in 1969 among white females in the United States. 
  • Acquisition of Clostridium difficile from the hospital environment. 
  • Adequacy of endogenous erythropoietin levels and mortality in anaemic heart failure patients. 
  • Adjuvant versus salvage radiation therapy for prostate cancer and the risk of death. 
  • Air pollution and lung cancer mortality in Harris County, Texas, 1979-1981. 
  • Alcohol consumption and blood pressure in black adults: the Pitt County Study. 
  • An approach to conducting epidemiologic research within cooperative clinical trials groups. 
  • An outbreak of Shigella sonnei gastroenteritis on Colorado River raft trips. 
  • Approaches to monitoring biological outcomes for HPV vaccination: challenges of early adopter countries. 
  • Are comparisons the answer to understanding behavioral aspects of aging in racial and ethnic groups? 
  • Asbestos fibre dimensions and lung cancer mortality among workers exposed to chrysotile. 
  • Assessing the clinical effectiveness of preventive maneuvers: analytic principles and systematic methods in reviewing evidence and developing clinical practice recommendations. A report by the Canadian Task Force on the Periodic Health Examination. 
  • Assessment of myocardial infarction by cardiac magnetic resonance imaging and long-term mortality. 
  • Association of depression and survival in patients with chronic heart failure over 12 Years. 
  • Association of education with incidence of cognitive impairment in three established populations for epidemiologic studies of the elderly. 
  • Associations of major bleeding and myocardial infarction with the incidence and timing of mortality in patients presenting with non-ST-elevation acute coronary syndromes: a risk model from the ACUITY trial. 
  • Atrial fibrillation management strategies and early mortality after myocardial infarction: results from the Valsartan in Acute Myocardial Infarction (VALIANT) Trial. 
  • Bayesian isotonic regression and trend analysis. 
  • Bayesian latent factor regression for functional and longitudinal data. 
  • Carcinomas in children. Clinical and demographic characteristics. 
  • Caries experience associated with attention-deficit/hyperactivity disorder. 
  • Changes in alkaline phosphatase levels in patients with prostate cancer receiving degarelix or leuprolide: results from a 12-month, comparative, phase III study. 
  • Changes in health status among participants of the Framingham Heart Study from the 1960s to the 1990s: application of an index of cumulative deficits. 
  • Childhood cancer and occupational radiation exposure in parents. 
  • Clear cell adenocarcinoma of the vagina and cervix: incidence, undetected disease, and diethylstilbestrol. 
  • Clinical Relevance of Rehospitalizations for Unstable Angina and Unplanned Revascularization Following Acute Myocardial Infarction. 
  • Clinical and epidemiologic features of Rocky Mountain spotted fever in Mississippi, 1933-1973. 
  • Clinical data bases. Accomplishments and unrealized potential. 
  • Clinical predictors of renal mass pathological features. 
  • Clinical, radiographic, molecular and MRI-based predictors of cartilage loss in knee osteoarthritis. 
  • Combined low-dose flutamide plus finasteride vs low-dose flutamide monotherapy for recurrent prostate cancer: a comparative analysis of two phase II trials with a long-term follow-up. 
  • Combining biological gene expression signatures in predicting outcome in breast cancer: An alternative to supervised classification. 
  • Commentary: Sir Arthur Mitchell--pioneer of psychiatric epidemiology and of community care. 
  • Comorbidity. 
  • Comparison of complication rates of porous anophthalmic orbital implants. 
  • Comparison of prostate-specific antigen recurrence-free survival in a contemporary cohort of patients undergoing either radical retropubic or robot-assisted laparoscopic radical prostatectomy. 
  • Compartment model approaches for estimating the parameters of a chronic disease process under changing risk factor exposures. 
  • Controversies in community-based psychiatric epidemiology: let the data speak for themselves. 
  • Coronary artery disease epidemic in Pakistan: more electrocardiographic evidence of ischaemia in women than in men. 
  • Criteria for the use of Sartwell's incubation period model to study chronic diseases with uncertain etiology. 
  • Cultural concepts of distress and psychiatric disorders: literature review and research recommendations for global mental health epidemiology. 
  • Cutpoint selection for categorizing a continuous predictor. 
  • DNA adduct formation by 12 chemicals with populations potentially suitable for molecular epidemiological studies. 
  • Design and conduct of occupational epidemiology studies: I. Design aspects of cohort studies. 
  • Design and conduct of occupational epidemiology studies: II. Analysis of cohort data. 
  • Design and conduct of occupational epidemiology studies: III. Design aspects of case-control studies. 
  • Design and conduct of occupational epidemiology studies: IV. The analysis of case-control data. 
  • Design, methodological issues and participation in a multiple sclerosis case-control study. 
  • Development and longitudinal validation of the overall benefit of analgesia score: a simple multi-dimensional quality assessment instrument. 
  • Development and validation of a rapid assessment tool for malaria prevention. 
  • Developments in child psychiatric epidemiology. 
  • Diagnostic tests: understanding results, assessing utility, and predicting performance. 
  • Dihydropiridine calcium-channel blockers and perioperative mortality in aortic aneurysm surgery. 
  • Dysfunctional labor: Case definition & guidelines for data collection, analysis, and presentation of immunization safety data. 
  • ESC Forum on Drug Eluting Stents European Heart House, Nice, 27-28 September 2007. 
  • Effect of pulmonary tuberculosis on mortality in patients receiving HAART. 
  • Epidemic Shiga bacillus dysentery in Central America. II. Epidemiologic studies in 1969. 
  • Epidemiological marker for oxidant status: comparison of the ELISA and the gas chromatography/mass spectrometry assay for urine 2,3-dinor-5,6-dihydro-15-F2t-isoprostane. 
  • Epidemiological modeling of acute mountain sickness (AMS). A prospective data collection standard. 
  • Epidemiologists, our patient is society. 
  • Erectile function after posterior urethroplasty for pelvic fracture-urethral distraction defect injuries. 
  • Established populations for epidemiologic studies of the elderly: study design and methodology. 
  • Estimating Survival in Patients With Lung Cancer and Brain Metastases: An Update of the Graded Prognostic Assessment for Lung Cancer Using Molecular Markers (Lung-molGPA). 
  • Estimating crude or common odds ratios in case-control studies with informatively missing exposure data. 
  • Estimating quality-adjusted life year losses associated with visual field deficits using methodological approaches. 
  • Estimating the occurrence of amyotrophic lateral sclerosis among Gulf War (1990-1991) veterans using capture-recapture methods. 
  • Ethnicity and gestational diabetes in New York City, 1995-2003. 
  • Evaluation metrics for biostatistical and epidemiological collaborations. 
  • Evidence-based therapy prescription in high-cardiovascular risk patients: the REACT study. 
  • Examining the relationship between uterine fibroids and dyspareunia among premenopausal women in the United States. 
  • Exposures and mortality among chrysotile asbestos workers. Part II: mortality. 
  • External validation of the SEARCH model for predicting aggressive recurrence after radical prostatectomy: results from the Duke Prostate Center Database. 
  • Factors influencing variation in prescribing of antidepressants by general practices in Scotland. 
  • Familial aggregation of age-related macular degeneration in the Utah population. 
  • Familial aggregation of multiple myeloma and central nervous system diseases. 
  • Familial ovarian cancer: a population-based case-control study. 
  • Follow-up study of chrysotile textile workers: cohort mortality and exposure-response. 
  • From correlates to causes: can quasi-experimental studies and statistical innovations bring us closer to identifying the causes of antisocial behavior? 
  • Gender and heart disease. 
  • Genetic epidemiology of the susceptibility to leprosy. 
  • Head-to-head comparison of the Lyon Schuss and fixed flexion radiographic techniques. Long-term reproducibility in normal knees and sensitivity to change in osteoarthritic knees. 
  • High-intensity focused ultrasound for prostate cancer: comparative definitions of biochemical failure. 
  • Histone H4 acetylation by immunohistochemistry and prognosis in relapsed acute lymphocytic leukaemia (ALL). 
  • I Brazilian Registry of Heart Failure - Clinical Aspects, Care Quality and Hospitalization Outcomes. 
  • Identifying a national death index match. 
  • Impact of a medical journal club on house-staff reading habits, knowledge, and critical appraisal skills. A randomized control trial. 
  • Impact of diabetes on outcomes in patients with low and preserved ejection fraction heart failure: an analysis of the Candesartan in Heart failure: Assessment of Reduction in Mortality and morbidity (CHARM) programme. 
  • Impact of early surgery on survival of patients with severe mitral regurgitation. 
  • Improving mental health practices in primary care: findings from recent research. 
  • Increased incidence of cervical and vaginal dysplasia in 3,980 diethylstilbestrol-exposed young women. Experience of the National Collaborative Diethylstilbestrol Adenosis Project. 
  • Industrial hygiene involvement in occupational epidemiology. 
  • Inference for nonlinear epidemiological models using genealogies and time series. 
  • Injury history as a risk factor for incident injury in youth soccer. 
  • Interdependent effects of cohesion and concurrency for epidemic potential. 
  • Invited commentary: positivity in practice. 
  • Karyotyping of Cryptococcus neoformans as an epidemiological tool. 
  • Knowledge and beliefs associated with refractive errors and undercorrection: the Singapore Malay Eye Study. 
  • Laboratory methods for assessing human semen in epidemiologic studies: a consensus report. 
  • Laparoscopic Approach in Colonic Diverticulitis: Dispelling Myths and Misperceptions. 
  • Learning from 2523 trauma deaths in India- opportunities to prevent in-hospital deaths. 
  • Long-term outcomes following microwave ablation for liver malignancies. 
  • Longitudinal change in clinical fracture incidence after initiation of bisphosphonates. 
  • Los Angeles student nurse study. Daily symptom reporting and photochemical oxidants. 
  • Mantel-Haenszel statistics and direct standardization. 
  • Mathematical models in decision analysis. 
  • Meta-analysis of high- versus low-chloride content in perioperative and critical care fluid resuscitation. 
  • Methodologic issues in a population-based health survey of Gulf War veterans. 
  • Methodological considerations in observational comparative effectiveness research for implantable medical devices: an epidemiologic perspective. 
  • Methodology of the Singapore Indian Chinese Cohort (SICC) eye study: quantifying ethnic variations in the epidemiology of eye diseases in Asians. 
  • Modeling disease incidence data with spatial and spatio temporal dirichlet process mixtures. 
  • Multiple imputation for missing data via sequential regression trees. 
  • Multiple myeloma and family history of cancer. A case-control study. 
  • Music meets surgery: two sides to the art of "healing". 
  • Nonparametric inference on median residual life function. 
  • Obese African-Americans with prostate cancer (T1c and a prostate-specific antigen, PSA, level of <10 ng/mL) have higher-risk pathological features and a greater risk of PSA recurrence than non-African-Americans. 
  • Obesity and oncological outcome after radical prostatectomy: impact of prostate-specific antigen-based prostate cancer screening: results from the Shared Equal Access Regional Cancer Hospital and Duke Prostate Center databases. 
  • Obesity and positive surgical margins by anatomic location after radical prostatectomy: results from the Shared Equal Access Regional Cancer Hospital database. 
  • Outcomes of medicare beneficiaries with heart failure and atrial fibrillation. 
  • Perceptions of weight discrimination: prevalence and comparison to race and gender discrimination in America. 
  • Perspectives on statistical significance testing. 
  • Population impact of mortality reduction: the effects of elimination of major causes of death on the 'saved' population. 
  • Post-myocardial infarction smoking cessation counseling: associations with immediate and late mortality in older Medicare patients. 
  • Potential misinterpretation of the case-only study to assess gene-environment interaction. 
  • Pre-operative homocysteine levels and morbidity and mortality following cardiac surgery. 
  • Predicting Outcomes Over Time in Patients With Heart Failure, Left Ventricular Systolic Dysfunction, or Both Following Acute Myocardial Infarction. 
  • Predicting freedom from clinical events in non-ST-elevation acute coronary syndromes: the Global Registry of Acute Coronary Events. 
  • Predicting which people with psychosocial distress are at risk of becoming dependent on state benefits: analysis of routinely available data. 
  • Prediction of risk of death and myocardial infarction in the six months after presentation with acute coronary syndrome: prospective multinational observational study (GRACE). 
  • Prediction of subsequent ischemic heart disease using serial resting electrocardiograms. 
  • Predictors of prolonged operative time during robot-assisted laparoscopic radical prostatectomy. 
  • Predictors of secondary treatment following biochemical recurrence after radical prostatectomy: results from the Shared Equal Access Regional Cancer Hospital database. 
  • Prenatal diethylstilbestrol exposure and human genital tract abnormalities. 
  • Prevalence and prognostic implications of electrocardiographic left ventricular hypertrophy in heart failure: evidence from the CHARM programme. 
  • Primary ocular adnexal mucosa-associated lymphoid tissue lymphoma (MALT): single institution experience in a large cohort of patients. 
  • Projecting chronic disease prevalence. 
  • Prospective study of incident injuries among southeastern United States commercial fishermen. 
  • Prospective validation of the Bleeding Academic Research Consortium classification in the all-comer PRODIGY trial. 
  • Prostate cancer and diet: food for thought? 
  • Prostate cancer: a significant risk factor for late-life suicide. 
  • Prostate-specific antigen velocity based risk-adapted discontinuation of prostate cancer screening in elderly men. 
  • Protecting Confidentiality in Cancer Registry Data With Geographic Identifiers. 
  • Psychiatric diagnoses of medical service users: evidence from the Epidemiologic Catchment Area Program. 
  • Psychiatric disorders in adult children of alcoholics: data from the Epidemiologic Catchment Area project. 
  • Pyogenic liver abscesses: mortality-related factors. 
  • Randomized controlled, multicentre clinical trial comparing a dual-probe ultrasonic lithotrite with a single-probe lithotrite for percutaneous nephrolithotomy. 
  • Randomized trial showed requesting medical records with a survey produced a more representative sample than requesting separately. 
  • Rasch analysis informed the development of a classification system for a diabetes-specific preference-based measure of health. 
  • Rationale and methodology for a population-based study of eye diseases in Malay people: The Singapore Malay eye study (SiMES). 
  • Rationale, design, methodology, and baseline data of a population-based study in rural China: the Handan Eye Study. 
  • Re-calibration and external validation of an existing nomogram to predict aggressive recurrences after radical prostatectomy. 
  • Re: "Ordinal regression models for epidemiologic data". 
  • Regression analysis of matched case-control data. 
  • Relation of prescription nonsteroidal antiinflammatory drug use to cognitive function among community-dwelling elderly. 
  • Relative impact of maternal depression and associated risk factors on offspring psychopathology. 
  • Renal impairment, worsening renal function, and outcome in patients with heart failure: an updated meta-analysis. 
  • Research Methods in Healthcare Epidemiology and Antimicrobial Stewardship-Mathematical Modeling. 
  • Research Methods in Healthcare Epidemiology and Antimicrobial Stewardship. 
  • Response rates to a questionnaire 26 years after baseline examination with minimal interim participant contact and baseline differences between respondents and nonrespondents. 
  • Retinopathy of prematurity in the United States. 
  • Risk factors for estrogen receptor-positive breast cancer. 
  • Risk factors for nuclear, cortical and posterior subcapsular cataracts in the Chinese population of Singapore: the Tanjong Pagar Survey. 
  • Risk of smoking and receipt of cessation services among veterans with mental disorders. 
  • Risk stratification in ST-elevation myocardial infarction is enhanced by combining baseline ST deviation and subsequent ST-segment resolution. 
  • Risk stratification of serious adverse events after gastric bypass in the Bariatric Outcomes Longitudinal Database. 
  • Robot-assisted laparoscopic prostatectomy is not associated with early postoperative radiation therapy. 
  • Sensitivity and specificity of standardized screens of cognitive impairment and dementia among elderly black and white community residents. 
  • Sequential phase II Southwest Oncology Group studies (S0112 and S0301) of daunorubicin and cytarabine by continuous infusion, without and with ciclosporin, in older patients with previously untreated acute myeloid leukaemia. 
  • Shigellosis at sea: an outbreak aboard a passenger cruise ship. 
  • Short- and long-term outcomes following atrial fibrillation in patients with acute coronary syndromes with or without ST-segment elevation. 
  • Social support and hypertension among blacks and whites in a rural, southern community. 
  • Social support and mortality in an elderly community population. 
  • Socioeconomic inequalities in oral health in childhood and adulthood in a birth cohort. 
  • Somatization disorder in the community. A study of diagnostic concordance among three diagnostic systems. 
  • Some features of the spread of epidemics and information on a random graph. 
  • Statistical modelling of lung cancer and laryngeal cancer incidence in Scotland, 1960-1979. 
  • Statistics for hospital epidemiology. General design and analysis questions. 
  • Synthesis of environmental evidence: nitrogen dioxide epidemiology studies. 
  • Tadalafil administered once daily for lower urinary tract symptoms secondary to benign prostatic hyperplasia: a 1-year, open-label extension study. 
  • Testing for contributions of mitochondrial DNA mutations to complex diseases. 
  • Testing homogeneity of two zero-inflated Poisson populations. 
  • The Aging, Demographics, and Memory Study: study design and methods. 
  • The NCDR ACTION Registry-GWTG: transforming contemporary acute myocardial infarction clinical care. 
  • The NIMH Epidemiologic Catchment Area program. Historical context, major objectives, and study population characteristics. 
  • The Shared Equal Access Regional Cancer Hospital (SEARCH) nomogram for risk stratification in intermediate risk group of men with prostate cancer: validation in the Duke Prostate Center database. 
  • The U.S. Food and Drug Administration's Mini-Sentinel program: status and direction. 
  • The association between prostate size and Gleason score upgrading depends on the number of biopsy cores obtained: results from the Shared Equal Access Regional Cancer Hospital Database. 
  • The contribution of hypertension to mortality in the US: 1968, 1977. 
  • The effect of involuntary job loss on smoking intensity and relapse. 
  • The epidemiologic evidence for a relationship between social support and health. 
  • The epidemiology of psychiatric disorders in the elderly. 
  • The high prevalence of substance use disorders among recent MDMA users compared with other drug users: Implications for intervention. 
  • The impact of religious practice and religious coping on geriatric depression. 
  • The interleukin 1 inhibitor rilonacept in treatment of chronic gouty arthritis: results of a placebo-controlled, monosequence crossover, non-randomised, single-blind pilot study. 
  • The iowa structured psychiatric interview. Rationale, reliability, and validity. 
  • The prevalence of and risk factors for pterygium in an urban Malay population: the Singapore Malay Eye Study (SiMES). 
  • The primary care physician and the psychiatric epidemiologist: a symbiotic service research partnership. 
  • The prognostic significance of heart rate in patients hospitalized for heart failure with reduced ejection fraction in sinus rhythm: insights from the EVEREST (Efficacy of Vasopressin Antagonism in Heart Failure: Outcome Study With Tolvaptan) trial. 
  • The pulmonary arterial hypertension quality enhancement research initiative: comparison of patients with idiopathic PAH to patients with systemic sclerosis-associated PAH. 
  • The relation of computer-based measures of sperm morphology and motility to male infertility. 
  • The theory and practice of psychiatry in the Soviet Union. 
  • The use of mortality time series data to produce hypothetical morbidity distributions and projects mortality trends. 
  • Throw that epidemiologist out of the emergency room! Using the television series ER as a vehicle for teaching methodologists about medical issues. 
  • Trends in US suicide mortality rates 1968 to 1982: race and sex differences in age, period and cohort components. 
  • Trends in acute reperfusion therapy for ST-segment elevation myocardial infarction from 1999 to 2006: we are getting better but we have got a long way to go. 
  • Two-level stochastic search variable selection in GLMs with missing predictors. 
  • U.S. cancer mortality 1950-1978: a strategy for analyzing spatial and temporal patterns. 
  • Usefulness of clinical and NT-proBNP monitoring for prognostic guidance in destabilized heart failure outpatients. 
  • Using Kendall's tau b correlations to improve variable selection methods in case-control studies. 
  • Using epidemiologic survey data to plan geriatric mental health services. 
  • Weight loss and mortality risk in patients with chronic heart failure in the candesartan in heart failure: assessment of reduction in mortality and morbidity (CHARM) programme. 
  • When epidemiology meets the Internet: Web-based surveys in the Millennium Cohort Study. 
  • Who's crazy in Manhattan: a reexamination of "treatment of psychological disorders among urban children". 
  • Workshop on fiber toxicology research needs. 
  • X-LRT: a likelihood approach to estimate genetic risks and test association with X-linked markers using a case-parents design. 
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  Keywords of People

  • Charles, Hal Cecil, Associate Professor of Radiology, Radiology
  • Curtis, Lesley H., Professor in Population Health Sciences, Medicine, General Internal Medicine
  • Dement, John McCray, Professor Emeritus in Family Medicine and Community Health, Community and Family Medicine, Occupational & Environmental Medicine
  • Dunson, David B., Arts and Sciences Professor of Statistical Science, Mathematics
  • Fisher, Deborah Anne, Associate Professor of Medicine, Medicine, Gastroenterology
  • Grambow, Steven C., Assistant Professor of Biostatistics and Bioinformatics, Biostatistics & Bioinformatics
  • Koontz, Bridget Fey, Associate Professor of Radiation Oncology, Radiation Oncology
  • Merli, M. Giovanna, Professor in the Sanford School of Public Policy, Duke Global Health Institute
  • Muir, Kelly Walton, Associate Professor of Ophthalmology, Ophthalmology, Glaucoma
  • O'Connor, Christopher Michael, Richard Sean Stack, M.D. / Guidant Foundation Professor of Cardiology, Medicine, Clinical Pharmacology
  • Odgers, Candice L., Research Professor in the Sanford School of Public Policy, Sanford School of Public Policy
  • Ostbye, Truls, Professor of Family Medicine and Community Health, Community and Family Medicine
  • Preminger, Glenn Michael, James F. Glenn, M.D. Professor of Urology, Surgery
  • Stinnett, Sandra Sue, Associate Professor of Biostatistics and Bioinformatics, Biostatistics & Bioinformatics
  • Wu, Li-Tzy, Professor in Psychiatry and Behavioral Sciences, Medicine, General Internal Medicine