Epidermis

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  Subject Areas on Research

  • A conserved retromer-independent function for RAB-6.2 in C. elegans epidermis integrity. 
  • A transgenic toolkit for visualizing and perturbing microtubules reveals unexpected functions in the epidermis. 
  • AKT1 gene mutation levels are correlated with the type of dermatologic lesions in patients with Proteus syndrome. 
  • Actin-related protein2/3 complex regulates tight junctions and terminal differentiation to promote epidermal barrier formation. 
  • Activin enhances skin tumourigenesis and malignant progression by inducing a pro-tumourigenic immune cell response. 
  • Acute and Chronic Ophthalmic Involvement in Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis - A Comprehensive Review and Guide to Therapy. II. Ophthalmic Disease. 
  • An unusual photoactivated skin eruption. Quinidine-induced livedo reticularis. 
  • Angiotensin II stimulates canonical TGF-β signaling pathway through angiotensin type 1 receptor to induce granulation tissue contraction. 
  • Anti-cell surface pemphigus autoantibody stimulates plasminogen activator activity of human epidermal cells. A mechanism for the loss of epidermal cohesion and blister formation. 
  • Anti-epidermal-cell-surface pemphigus antibody detaches viable epidermal cells from culture plates by activation of proteinase. 
  • Antibody-induced proteinase activation: a proposed mechanism for pemphigus. 
  • Apoptotic force and tissue dynamics during Drosophila embryogenesis. 
  • Asymmetric cell divisions promote stratification and differentiation of mammalian skin. 
  • Autodegradation of 125I-labeled human epidermal cell surface proteins. 
  • CDK2 activation in mouse epidermis induces keratinocyte proliferation but does not affect skin tumor development. 
  • CDK4 regulation by TNFR1 and JNK is required for NF-kappaB-mediated epidermal growth control. 
  • CYLD inhibits tumorigenesis and metastasis by blocking JNK/AP1 signaling at multiple levels. 
  • Cell adhesion in epidermal development and barrier formation. 
  • Characterization of a cDNA clone encoding human filaggrin and localization of the gene to chromosome region 1q21. 
  • Characterization of cis-regulatory elements controlling repo transcription in Drosophila melanogaster. 
  • Characterization of human thymic epithelial cell surface antigens: phenotypic similarity of thymic epithelial cells to epidermal keratinocytes. 
  • Characterization of keratinocyte plasminogen activator inhibitors and demonstration of the prevention of pemphigus IgG-induced acantholysis by a purified plasminogen activator inhibitor. 
  • Chemical skin carcinogenesis is prevented in mice by the induced expression of a TGF-beta related transgene. 
  • Clinical Improvements in Very Dry Skin from a Natural Ingredient-Based Moisturizing Cream Compared With a Leading Colloidal Oatmeal Control. 
  • Complete canthi removal reveals that forces from the amnioserosa alone are sufficient to drive dorsal closure in Drosophila. 
  • Degradation of the epidermal-dermal junction by proteolytic enzymes from human skin and human polymorphonuclear leukocytes. 
  • Dendritic epidermal T cells regulate skin antimicrobial barrier function. 
  • Desmoplakin: an unexpected regulator of microtubule organization in the epidermis. 
  • Differential expression of plasminogen activators and their inhibitors in an organotypic skin coculture system. 
  • Differentiated Daughter Cells Regulate Stem Cell Proliferation and Fate through Intra-tissue Tension. 
  • Directionality of wingless protein transport influences epidermal patterning in the Drosophila embryo. 
  • Drosophila APC2 is a cytoskeletally-associated protein that regulates wingless signaling in the embryonic epidermis. 
  • Drosophila RhoA regulates the cytoskeleton and cell-cell adhesion in the developing epidermis. 
  • Effects of acid-stress on epidermal mucous cells of the brown bullhead Ictalurus nebulosus (LeSeur): a morphometric study. 
  • Emergent properties during dorsal closure in Drosophila morphogenesis. 
  • Engineering the tissue which encapsulates subcutaneous implants. I. Diffusion properties. 
  • Epidermal denervation and its effects on keratinocytes and Langerhans cells. 
  • Epidermal plasminogen activator is abnormal in cutaneous lesions. 
  • Epidermal structure and differentiation. 
  • Expression of antigens by cultured epithelial cells: comparison of epidermis and thymic epithelium. 
  • Expression of plasminogen activator inhibitor type 2 in normal and psoriatic epidermis. 
  • Expression of plasminogen activators in basal cell carcinoma. 
  • Expression of unusually large keratins during terminal differentiation: balance of type I and type II keratins is not disrupted. 
  • FRAP analysis reveals stabilization of adhesion structures in the epidermis compared to cultured keratinocytes. 
  • Functional analysis of Wingless reveals a link between intercellular ligand transport and dorsal-cell-specific signaling. 
  • Granulysin is a key mediator for disseminated keratinocyte death in Stevens-Johnson syndrome and toxic epidermal necrolysis. 
  • Growth and development of the barnacle Amphibalanus amphitrite: time and spatially resolved structure and chemistry of the base plate. 
  • Histologic evaluation of the long term effects of tretinoin on photodamaged skin. 
  • Human S100A15 splice variants are differentially expressed in inflammatory skin diseases and regulated through Th1 cytokines and calcium. 
  • Human epidermal plasminogen activator. Characterization, localization, and modulation. 
  • Human skin proteinases as inflammatory mediators. 
  • Identification and characterization of small molecule inducers of epidermal keratinocyte differentiation 
  • Identifying Genetic Players in Cell Sheet Morphogenesis Using a Drosophila Deficiency Screen for Genes on Chromosome 2R Involved in Dorsal Closure. 
  • Identifying Key Genetic Regions for Cell Sheet Morphogenesis on Chromosome 2L Using a Drosophila Deficiency Screen in Dorsal Closure. 
  • Induction of lef1 during zebrafish fin regeneration. 
  • Injury enhances TLR2 function and antimicrobial peptide expression through a vitamin D-dependent mechanism. 
  • Intrauterine epidermal necrosis. 
  • Involvement of urokinase-type plasminogen activator in acantholysis induced by pemphigus IgG. 
  • KIF18B is a cell type-specific regulator of spindle orientation in the epidermis. 
  • Keratinocyte urokinase-type plasminogen activator is secreted as a single chain precursor. 
  • Lack of cyclin-dependent kinase 4 inhibits c-myc tumorigenic activities in epithelial tissues. 
  • Lis1 is essential for cortical microtubule organization and desmosome stability in the epidermis. 
  • Local Burn Injury Promotes Defects in the Epidermal Lipid and Antimicrobial Peptide Barriers in Human Autograft Skin and Burn Margin: Implications for Burn Wound Healing and Graft Survival. 
  • Local Dkk1 crosstalk from breeding ornaments impedes regeneration of injured male zebrafish fins. 
  • Local burn injury impairs epithelial permeability and antimicrobial peptide barrier function in distal unburned skin. 
  • Loss of BMI1 in mature olfactory sensory neurons leads to increased olfactory basal cell proliferation. 
  • Loss of the Ubiquitin-conjugating Enzyme UBE2W Results in Susceptibility to Early Postnatal Lethality and Defects in Skin, Immune, and Male Reproductive Systems. 
  • Maintenance of blastemal proliferation by functionally diverse epidermis in regenerating zebrafish fins. 
  • Melanocytic tumors with intraepidermal melanophages: a report of five cases with review of 231 archived cutaneous melanocytic tumors. 
  • Mice lacking expression of secondary lymphoid organ chemokine have defects in lymphocyte homing and dendritic cell localization. 
  • Modulation of ultraviolet light-induced epidermal damage: beneficial effects of tocopherol. 
  • Molecular imaging of epidermal growth factor receptor in live cells with refractive index sensitivity using dark-field microspectroscopy and immunotargeted nanoparticles. 
  • Molecular size of secreted and cell-associated plasminogen activators from cultured epidermal cells. 
  • Monoclonal antibody 4F2 reactive with basal layer keratinocytes: studies in the normal and a hyperproliferative state. 
  • Morphogenesis in skin is governed by discrete sets of differentially expressed microRNAs. 
  • Mucosubstance histochemistry in control and acid-stressed epidermis of brown bullhead catfish, Ictalurus nebulosus (LeSueur). 
  • Multiple forces contribute to cell sheet morphogenesis for dorsal closure in Drosophila. 
  • Mutations in Drosophila crinkled/Myosin VIIA disrupt denticle morphogenesis. 
  • Mutualism or parasitism? Using a phylogenetic approach to characterize the oxpecker-ungulate relationship. 
  • NF-kappaB RelA opposes epidermal proliferation driven by TNFR1 and JNK. 
  • NF-kappaB blockade and oncogenic Ras trigger invasive human epidermal neoplasia. 
  • Nicotinic acetylcholine receptor stimulation impairs epidermal permeability barrier function and recovery and modulates cornified envelope proteins. 
  • Noncentrosomal microtubules and type II myosins potentiate epidermal cell adhesion and barrier formation. 
  • Organization of skin stratum corneum extracellular lamellae: diffraction evidence for asymmetric distribution of cholesterol. 
  • PSORS2 is due to mutations in CARD14. 
  • Pairing of competitive and topologically distinct regulatory modules enhances patterned gene expression. 
  • Penicillamine-induced pemphigus. Immunoglobulin from this patient induces plasminogen activator synthesis by human epidermal cells in culture: mechanism for acantholysis in pemphigus. 
  • Plasminogen activators in epithelial biology. 
  • Polarity and stratification of the epidermis. 
  • Polarity in skin development and cancer. 
  • Primary Cutaneous T-Cell Lymphomas Showing Gamma-Delta (γδ) Phenotype and Predominantly Epidermotropic Pattern are Clinicopathologically Distinct From Classic Primary Cutaneous γδ T-Cell Lymphomas. 
  • Proteinase activation: a mechanism for cellular dyshesion in pemphigus. 
  • Proteomic analysis of desmosomes reveals novel components required for epidermal integrity. 
  • Quantifying dorsal closure in three dimensions. 
  • RNA-Seq and ChIP-Seq reveal SQSTM1/p62 as a key mediator of JunB suppression of NF-κB-dependent inflammation. 
  • RacGap50C negatively regulates wingless pathway activity during Drosophila embryonic development. 
  • Reflectance confocal microscopy features of angioma serpiginosum. 
  • Regulated spindle orientation buffers tissue growth in the epidermis. 
  • Robust control of mitotic spindle orientation in the developing epidermis. 
  • Roles for Fgf signaling during zebrafish fin regeneration. 
  • Roles for Ndel1 in keratin organization and desmosome function. 
  • Roles of wingless in patterning the larval epidermis of Drosophila. 
  • Salt-split human skin substrate for the immunofluorescent screening of serum from patients with cicatricial pemphigoid and a new method of immunoprecipitation with IgA antibodies. 
  • Secretion and movement of wingless protein in the epidermis of the Drosophila embryo. 
  • Segment polarity gene interactions modulate epidermal patterning in Drosophila embryos. 
  • Serine proteinases in human cutaneous mastocytosis. 
  • Signaling activities of the Drosophila wingless gene are separately mutable and appear to be transduced at the cell surface. 
  • Skin-resident T cells sense ultraviolet radiation-induced injury and contribute to DNA repair. 
  • Skp2 deficiency inhibits chemical skin tumorigenesis independent of p27(Kip1) accumulation. 
  • Smad5 induces ventral fates in Xenopus embryo. 
  • SoxNeuro and Shavenbaby act cooperatively to shape denticles in the embryonic epidermis of Drosophila . 
  • Stat3 binds to mtDNA and regulates mitochondrial gene expression in keratinocytes. 
  • Stimulation of DNA synthesis in human epidermis by UVB radiation and its inhibition by difluoromethylornithine. 
  • TGFβ/Smad3 signal pathway is not required for epidermal Langerhans cell development. 
  • Target recognition by the archenteron during sea urchin gastrulation. 
  • Tenascin/hexabrachion in human skin: biochemical identification and localization by light and electron microscopy. 
  • The HMG-box transcription factor SoxNeuro acts with Tcf to control Wg/Wnt signaling activity. 
  • The Histone Methyltransferase Ash1l is Required for Epidermal Homeostasis in Mice. 
  • The effect of 13-cis retinoic acid on epidermal lysosomal hydrolase activity in Darier's disease and pityriasis rubra pilaris. 
  • The effect of corticosteroids, dapsone and gold upon plasminogen activator synthesis and secretion by human epidermal cells cultured with pemphigus antibody. 
  • The gene for a novel epidermal antigen maps near the neurofibromatosis 1 gene. 
  • The nature and significance of differential keratin gene expression. 
  • The role of adhesion molecules in epithelial-T-cell interactions in thymus and skin. 
  • Tissue plasminogen activator in psoriasis. 
  • Total nipple-areola complex necrosis in inferior pedicle breast reduction. 
  • Transient Receptor Potential Vanilloid 4 Ion Channel Functions as a Pruriceptor in Epidermal Keratinocytes to Evoke Histaminergic Itch. 
  • Transient laminin beta 1a Induction Defines the Wound Epidermis during Zebrafish Fin Regeneration. 
  • Two cases of transfusion-associated graft-vs-host disease after open heart surgery. 
  • Ultraviolet light and free radicals: an immunologic theory of epidermal carcinogenesis. 
  • X-ray diffraction analysis of isolated skin lipids: reconstitution of intercellular lipid domains. 
  • beta-Catenin protects the epidermis from mechanical stresses. 
  • mRNA for tissue-type plasminogen activator is present in lesional epidermis from patients with psoriasis, pemphigus, or bullous pemphigoid, but is not detected in normal epidermis. 
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  Keywords of People

  • Bejsovec, Amy, Associate Professor of Biology, Biology
  • Erickson, Harold Paul, James B. Duke Distinguished Professor Emeritus, Cell Biology
  • Lechler, Terry H., Professor in Dermatology, Cell Biology
  • Soderling, Scott Haydn, George Barth Geller Distinguished Professor of Molecular Biology, Cell Biology