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Subject Areas on Research
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A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure.
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A centenarian-only approach for assessing gene-gene interaction in human longevity.
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A comprehensive genome-wide analysis of melanoma Breslow thickness identifies interaction between CDC42 and SCIN genetic variants.
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A genome-wide RNAi screen reveals multiple regulators of caspase activation.
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A genome-wide association study of resistance to HIV infection in highly exposed uninfected individuals with hemophilia A.
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A hybrid framework for genome wide epistasis discovery.
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A tripartite interaction among alleles of Notch, Delta, and Enhancer of split during imaginal development of Drosophila melanogaster.
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APOE, TOMM40, and sex interactions on neural network connectivity.
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Activation of an EDS1-mediated R-gene pathway in the snc1 mutant leads to constitutive, NPR1-independent pathogen resistance.
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Adaptive evolution: evaluating empirical support for theoretical predictions.
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An "almost exhaustive" search-based sequential permutation method for detecting epistasis in disease association studies.
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An analysis paradigm for investigating multi-locus effects in complex disease: examination of three GABA receptor subunit genes on 15q11-q13 as risk factors for autistic disorder.
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Assessment of LD matrix measures for the analysis of biological pathway association.
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Associations of PI3KR1 and mTOR polymorphisms with esophageal squamous cell carcinoma risk and gene-environment interactions in Eastern Chinese populations.
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CD19 hyperexpression augments Sle1-induced humoral autoimmunity but not clinical nephritis.
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Coevolution of self-fertilization and inbreeding depression. III. Homozygous lethal mutations at multiple loci.
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Comparative analysis of quantitative trait loci controlling glucosinolates, myrosinase and insect resistance in Arabidopsis thaliana.
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Complete genomic screen for disease susceptibility loci in nuclear families.
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Constitutive disease resistance requires EDS1 in the Arabidopsis mutants cpr1 and cpr6 and is partially EDS1-dependent in cpr5.
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Cytokinesis proteins Tum and Pav have a nuclear role in Wnt regulation.
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Dependence of epistasis on environment and mutation severity as revealed by in silico mutagenesis of phage t7.
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Dependence of the regulation of telomere length on the type of subtelomeric repeat in the yeast Saccharomyces cerevisiae.
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Dissection of genetic pathways in C. elegans.
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Drosophila APC2 is a cytoskeletally-associated protein that regulates wingless signaling in the embryonic epidermis.
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Epistasis among Drosophila persimilis factors conferring hybrid male sterility with D. pseudoobscura bogotana.
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Epistasis amongst PTPN2 and genes of the vitamin D pathway contributes to risk of juvenile idiopathic arthritis.
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Epistasis and balanced polymorphism influencing complex trait variation.
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Epistasis between polymorphisms in COMT, ESR1, and GCH1 influences COMT enzyme activity and pain.
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Epistasis modifies the dominance of loci causing hybrid male sterility in the Drosophila pseudoobscura species group.
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Epistatic Gene-Based Interaction Analyses for Glaucoma in eMERGE and NEIGHBOR Consortium.
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Epistatic genetic interactions govern morphogenesis during sexual reproduction and infection in a global human fungal pathogen.
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Epistatic roles for Pseudomonas aeruginosa MutS and DinB (DNA Pol IV) in coping with reactive oxygen species-induced DNA damage.
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Evaluation of allelic strength of human TET2 mutations and cooperation between Tet2 knockdown and oncogenic Nras mutation.
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Evidence of biologic epistasis between BDNF and SLC6A4 and implications for depression.
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Examination of the roles of Sgs1 and Srs2 helicases in the enforcement of recombination fidelity in Saccharomyces cerevisiae.
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From genotype to phenotype: systems biology meets natural variation.
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Functional genomic analysis of phagocytosis and identification of a Drosophila receptor for E. coli.
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Fungal genome and mating system transitions facilitated by chromosomal translocations involving intercentromeric recombination.
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G protein-coupled receptor Gpr4 senses amino acids and activates the cAMP-PKA pathway in Cryptococcus neoformans.
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Gene × dietary pattern interactions in obesity: analysis of up to 68 317 adults of European ancestry.
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Gene-educational attainment interactions in a multi-ancestry genome-wide meta-analysis identify novel blood pressure loci.
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Gene-gene Interaction Analyses for Atrial Fibrillation.
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Genetic Interactions in Nonsyndromic Orofacial Clefts in Europe-EUROCRAN Study.
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Genetic interaction screens identify a role for hedgehog signaling in Drosophila border cell migration.
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Genetic interactions among regulators of septin organization.
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Genetic interactions between Shox2 and Hox genes during the regional growth and development of the mouse limb.
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Genetic polymorphisms in tumor necrosis factor (TNF)-alpha and TNF-beta in a population-based study of systemic lupus erythematosus: associations and interaction with the interleukin-1alpha-889 C/T polymorphism.
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Genome-wide architecture of reproductive isolation in a naturally occurring hybrid zone between Mus musculus musculus and M. m. domesticus.
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Gpr1, a putative G-protein-coupled receptor, regulates morphogenesis and hypha formation in the pathogenic fungus Candida albicans.
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Haplotype associations with quantitative traits in the presence of complex multilocus and heterogeneous effects.
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Human Epistatic Interaction Controls IL7R Splicing and Increases Multiple Sclerosis Risk.
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Identification of quantitative trait loci influencing wood specific gravity in an outbred pedigree of loblolly pine.
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In vitro characterization of 6-[18F]fluoro-A-85380, a high-affinity ligand for alpha4beta2* nicotinic acetylcholine receptors.
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Integrated pathway and epistasis analysis reveals interactive effect of genetic variants at TERF1 and AFAP1L2 loci on melanoma risk.
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Interaction Between Peroxisome Proliferator Activated Receptor δ and Epithelial Membrane Protein 2 Polymorphisms Influences HDL-C Levels in the Chinese Population.
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Interactions of IL-12A and IL-12B polymorphisms on the risk of cervical cancer in Chinese women.
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Interplay between stress-related genes may influence Alzheimer's disease development: The results of genetic interaction analyses of human data.
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Kernel canonical correlation analysis for assessing gene-gene interactions and application to ovarian cancer.
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Loss of Drosophila melanogaster p21-activated kinase 3 suppresses defects in synapse structure and function caused by spastin mutations.
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MCP1 SNPs and pulmonary tuberculosis in cohorts from West Africa, the USA and Argentina: lack of association or epistasis with IL12B polymorphisms.
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Mapping of QTL for resistance against the crucifer specialist herbivore Pieris brassicae in a new Arabidopsis inbred line population, Da(1)-12 x Ei-2.
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Mice mutant for Egfr and Shp2 have defective cardiac semilunar valvulogenesis.
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Mitochondrial Genome Variation Affects Multiple Respiration and Nonrespiration Phenotypes in Saccharomyces cerevisiae.
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Model selection in binary trait locus mapping.
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Multifactor dimensionality reduction reveals gene-gene interactions associated with multiple sclerosis susceptibility in African Americans.
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Natural and orthogonal model for estimating gene-gene interactions applied to cutaneous melanoma.
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Pde1 phosphodiesterase modulates cyclic AMP levels through a protein kinase A-mediated negative feedback loop in Cryptococcus neoformans.
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Pleiotropy and epistasis within and between signaling pathways defines the genetic architecture of fungal virulence.
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Protein phosphatase 2A and its B56 regulatory subunit inhibit Wnt signaling in Xenopus.
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Random Forests approach for identifying additive and epistatic single nucleotide polymorphisms associated with residual feed intake in dairy cattle.
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Recombination and the divergence of hybridizing species.
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Reduced mRNA expression of nucleotide excision repair genes in lymphocytes and risk of squamous cell carcinoma of the head and neck.
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Regulation of growth-defense balance by the JASMONATE ZIM-DOMAIN (JAZ)-MYC transcriptional module.
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Regulation of mitotic homeologous recombination in yeast. Functions of mismatch repair and nucleotide excision repair genes.
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Regulators of pseudohyphal differentiation in Saccharomyces cerevisiae identified through multicopy suppressor analysis in ammonium permease mutant strains.
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Requirement for the vasa RNA helicase in gurken mRNA localization.
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Role of Cdc42p in pheromone-stimulated signal transduction in Saccharomyces cerevisiae.
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Role of mismatch repair in the fidelity of RAD51- and RAD59-dependent recombination in Saccharomyces cerevisiae.
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Roles of RAD6 epistasis group members in spontaneous polzeta-dependent translesion synthesis in Saccharomyces cerevisiae.
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Scarecrow-like 3 promotes gibberellin signaling by antagonizing master growth repressor DELLA in Arabidopsis.
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Searching for epistatic interactions in nuclear families using conditional linkage analysis.
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Sequential elimination of major-effect contributors identifies additional quantitative trait loci conditioning high-temperature growth in yeast.
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Sex-specific incompatibility generates locus-specific rates of introgression between species.
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Shared genetic pathways contribute to the tolerance of endogenous and low-dose exogenous DNA damage in yeast.
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Stall encodes an ADAMTS metalloprotease and interacts genetically with Delta in Drosophila ovarian follicle formation.
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Statistical analysis of genetic interactions in Tn-Seq data.
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Studying genetic resilience to improve human health.
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Summary of contributions to GAW15 Group 13: candidate gene association studies.
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The APOE4 allele shows opposite sex bias in microbleeds and Alzheimer's disease of humans and mice.
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The HMG-box transcription factor SoxNeuro acts with Tcf to control Wg/Wnt signaling activity.
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The earliest stages of adaptation in an experimental plant population: strong selection on QTLs for seed dormancy.
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The genetic architecture of biofilm formation in a clinical isolate of Saccharomyces cerevisiae.
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The whole-genome landscape of medulloblastoma subtypes.
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Uncoupling PR-gene expression from NPR1 and bacterial resistance: Characterization of the dominant Arabidopsis cpr6 mutant.
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Understanding rice adaptation to varying agro-ecosystems: trait interactions and quantitative trait loci.
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Unifying genetic canalization, genetic constraint, and genotype-by-environment interaction: QTL by genomic background by environment interaction of flowering time in Boechera stricta.
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Use of pathway information in molecular epidemiology.
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Yeast pseudohyphal growth is regulated by GPA2, a G protein alpha homolog.
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Zebrafish second heart field development relies on progenitor specification in anterior lateral plate mesoderm and nkx2.5 function.
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Keywords of People