Erythropoiesis

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  Subject Areas on Research

  • Abnormal lipid composition of the red cell membrane in congenital dyserythropoietic anemia type II (HEMPAS). 
  • Accumulation of glycolipids containing N-acetylglucosamine in erythrocyte stroma of patients with congenital dyserythropoietic anemia type II (HEMPAS). 
  • Adducin in erythrocyte precursor cells of rats and humans: expression and compartmentalization. 
  • Anaemia in early infancy. 
  • Anemia of prematurity. 
  • Anemia of prematurity. 
  • Benefits of early intervention with erythropoiesis- stimulating proteins in chemotherapy-induced anemia. 
  • Co-operative signalling mechanisms required for erythroid precursor expansion in response to erythropoietin and stem cell factor. 
  • Donor Iron Deficiency Study (DIDS): protocol of a study to test whether iron deficiency in blood donors affects red blood cell recovery after transfusion. 
  • Dynamics of the epigenetic landscape during erythroid differentiation after GATA1 restoration. 
  • Effects of graded doses of testosterone on erythropoiesis in healthy young and older men. 
  • Effects of intravascular, intrauterine transfusion on prenatal and postnatal hemolysis and erythropoiesis in severe fetal isoimmunization. 
  • Erythrocyte adhesion receptors: blood group antigens and related molecules. 
  • Erythrocytes of the human neonate. 
  • Erythropoiesis-stimulating protein support and survival. 
  • Erythropoietin receptor signals both proliferation and erythroid-specific differentiation. 
  • Exome Genotyping Identifies Pleiotropic Variants Associated with Red Blood Cell Traits. 
  • FGF23 at the crossroads of phosphate, iron economy and erythropoiesis. 
  • Failure of red blood cell maturation in mice with defects in the high-density lipoprotein receptor SR-BI. 
  • Failure of terminal erythroid differentiation in EKLF-deficient mice is associated with cell cycle perturbation and reduced expression of E2F2. 
  • Familial polycythemia due to truncations of the erythropoietin receptor. 
  • Garlic accelerates red blood cell turnover and splenic erythropoietic gene expression in mice: evidence for erythropoietin-independent erythropoiesis. 
  • Gfi-1B controls human erythroid and megakaryocytic differentiation by regulating TGF-beta signaling at the bipotent erythro-megakaryocytic progenitor stage. 
  • Helix-loop-helix transcription factors E12 and E47 are not essential for skeletal or cardiac myogenesis, erythropoiesis, chondrogenesis, or neurogenesis. 
  • Hepcidin antimicrobial peptide transgenic mice exhibit features of the anemia of inflammation. 
  • Hepcidin as a therapeutic tool to limit iron overload and improve anemia in β-thalassemic mice. 
  • High levels of human gamma-globin gene expression in adult mice carrying a transgene of deletion-type hereditary persistence of fetal hemoglobin. 
  • Identification of a human heme exporter that is essential for erythropoiesis. 
  • Inducers of Friend leukaemic cell differentiation in vitro--effects of in vivo administration. 
  • Ineffective erythropoiesis in beta-thalassemia is characterized by increased iron absorption mediated by down-regulation of hepcidin and up-regulation of ferroportin. 
  • Inverse relationship between splenomegaly and stem cell compartment size in mice treated with nitrogen mustard. 
  • Ion fluxes and differentiation in transformed cell lines. 
  • Iron homeostasis and erythropoiesis. 
  • Late stage erythroid precursor production is impaired in mice with chronic inflammation. 
  • Nitric oxide, malaria, and anemia: inverse relationship between nitric oxide production and hemoglobin concentration in asymptomatic, malaria-exposed children. 
  • Phase I study of pharmacological and immunological effects of human lymphoblastoid interferon given to patients with cancer. 
  • Physicochemical characteristics and biological effects of nickel oxides. 
  • Polycythemia vera erythroid precursors exhibit increased proliferation and apoptosis resistance associated with abnormal RAS and PI3K pathway activation. 
  • Prospective evaluation of the association between cardiac troponin T and markers of disturbed erythropoiesis in patients with heart failure. 
  • Purification and characterization of the yeast-expressed erythropoietin mutant Epo (R103A), a specific inhibitor of human primary hematopoietic cell erythropoiesis. 
  • RBC transfusions in paroxysmal nocturnal hemoglobinuria. 
  • Receptors that induce erythroid differentiation of Ba/F3 cells: structural requirements and effect on STAT5 binding. 
  • Red cell disturbances in the feto-maternal unit. 
  • Regulation of iron absorption in Hfe mutant mice. 
  • Sequential activation of splenic nuclear RNA polymerases by erythropoietin. 
  • Slc11a2 is required for intestinal iron absorption and erythropoiesis but dispensable in placenta and liver. 
  • The anemia of prematurity and the decision when to transfuse. 
  • The in vitro growth of murine high proliferative potential-colony forming cells is not enhanced by growth in a low oxygen atmosphere. 
  • The molecular regulation of iron metabolism. 
  • The transferrin receptor modulates Hfe-dependent regulation of hepcidin expression. 
  • Transcriptional control of erythropoiesis. 
  • Transferrin is a major determinant of hepcidin expression in hypotransferrinemic mice. 
  • Transferrin receptor 1 is differentially required in lymphocyte development. 
  • Transferrin receptor is necessary for development of erythrocytes and the nervous system. 
  • Type II congenital dyserythropoietic anemia. 
  • Validation and potential mechanisms of red cell distribution width as a prognostic marker in heart failure. 
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  Keywords of People

  • O'Connor, Christopher Michael, Richard Sean Stack, M.D. Distinguished Professor, Medicine, Clinical Pharmacology