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Subject Areas on Research
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7alpha,11beta-Dimethyl-19-nortestosterone: a potent and selective androgen response modulator with prostate-sparing properties.
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A link between breast cancer and local estrogen biosynthesis suggested by quantification of breast adipose tissue aromatase cytochrome P450 transcripts using competitive polymerase chain reaction after reverse transcription.
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A longer duration of estrogen deficiency increases fibrosis risk among postmenopausal women with nonalcoholic fatty liver disease.
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A physiologic model of the dehydroepiandrosterone to estrogen conversion system in the fetoplacental unit. I. Development.
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A physiologic model of the dehydroepiandrosterone to estrogen conversion system in the fetoplacental unit. II. Preliminary clinical application--the dehydroepiandrosterone loading test.
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A randomized pilot trial of estrogen replacement therapy in post-menopausal women with Parkinson's disease.
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A reevaluation of the concept of separable periods of organizational and activational actions of estrogens in development of brain and behavior.
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Actions of steroids in mitochondria.
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Activity of a Py-Im polyamide targeted to the estrogen response element.
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Adrenomedullin expression in rat uterus is correlated with plasma estradiol.
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Age trends in estradiol and estrone levels measured using liquid chromatography tandem mass spectrometry in community-dwelling men of the Framingham Heart Study.
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Allosteric regulation of estrogen receptor structure, function, and coactivator recruitment by different estrogen response elements.
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Alpha adrenergic receptor subtypes in rabbit uterus: mediation of myometrial contraction and regulation by estrogens.
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Amenorrhea: observations based on the analysis of luteinizing hormone-releasing hormone testing.
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Anchoring ethinylestradiol induced gene expression changes with testicular morphology and reproductive function in the medaka.
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Androgen and estrogen treatment, alone or in combination, differentially influences bone maturation and hypothalamic mechanisms that time puberty in the male rhesus monkey (Macaca mulatta).
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Angiotensinogen synthesis in the liver is independent of physiological estrogen levels.
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Anterior cruciate ligament injuries in the female athlete.
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Apoptosis in atretic ovarian follicles is associated with selective decreases in messenger ribonucleic acid transcripts for gonadotropin receptors and cytochrome P450 aromatase.
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Application of the estrogen threshold hypothesis to the physiologic hypoestrogenemia of lactation.
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Assessing human fertility using several markers of ovulation.
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Assessment of sex steroid action in vitro.
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Association Between Menopausal Estrogen-Only Therapy and Ovarian Carcinoma Risk.
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Association of genetic polymorphisms of ER-alpha and the estradiol-synthesizing enzyme genes CYP17 and CYP19 with breast cancer risk in Chinese women.
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Biochemical identification of apoptosis (programmed cell death) in granulosa cells: evidence for a potential mechanism underlying follicular atresia.
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Biological and biochemical consequences of global deletion of exon 3 from the ER alpha gene.
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Biological assessment of bisphenol A degradation in water following direct photolysis and UV advanced oxidation.
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Biological assessments of a mixture of endocrine disruptors at environmentally relevant concentrations in water following UV/H2O2 oxidation.
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Blood pressure control and hormone replacement therapy in postmenopausal women at risk for coronary heart disease.
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Bone mineral content and levels of gonadotropins and estrogens in amenorrheic running women.
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Breast cancer and estrogen replacement therapy.
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Carcinoma of the prostate: the therapeutic dilemma.
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Case-based discussion on the implications of exogenous estrogens in hemostasis and thrombosis: the obstetrician's view.
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Cellular mechanisms which distinguish between hormone- and antihormone-activated estrogen receptor.
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Changing trends and prognostic features in endometrial cancer associated with exogenous estrogen therapy.
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Clinical response to hormone therapy correlated with estrogen receptor analyses. Biochemical v histochemical methods.
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Coactivation of liver receptor homologue-1 by peroxisome proliferator-activated receptor gamma coactivator-1alpha on aromatase promoter II and its inhibition by activated retinoid X receptor suggest a novel target for breast-specific antiestrogen therapy.
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Coactivator AIB1 links estrogen receptor transcriptional activity and stability.
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Combination drug therapy for Alzheimer's disease: what is evidence-based, and what is not?
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Combination therapy for early Alzheimer's disease: what are we waiting for?
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Coming of age: steroid hormones of wild immature baboons, Papio cynocephalus
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Compartmental ovarian steroidogenesis in polycystic ovary syndrome.
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Connections and regulation of the human estrogen receptor.
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Creation of an active estrogen-responsive element by a single base change in the flanking sequence of a cellular oncogene: a possible mechanism for hormonal carcinogenesis?
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Current and future treatments for cognitive deficits in dementia.
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Decreased beta-adrenergic responses in the female rat brain are eliminated by ovariectomy: correlation of [3H]dihydroalprenolol binding and catecholamine stimulated cyclic AMP levels.
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Decreased intracellular potassium levels underlie increased progesterone synthesis during ovarian follicular atresia.
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Determination of hormonal steroid concentrations in biological extracts by high resolution mass fragmentography.
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Determination of steroid estrogens in wastewater by immunoaffinity extraction coupled with HPLC-electrospray-MS.
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Development of an ER action indicator mouse for the study of estrogens, selective ER modulators (SERMs), and Xenobiotics.
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Development of the external genitalia: perspectives from the spotted hyena (Crocuta crocuta).
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Dietary intervention study to assess estrogenicity of dietary soy among postmenopausal women.
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Differential molecular mechanism of the estrogen action that regulates lactoferrin gene in human and mouse.
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Differential recruitment of co-regulatory proteins to the human estrogen receptor 1 in response to xenoestrogens.
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Disruption of the mouse oestrogen receptor gene: resulting phenotypes and experimental findings.
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Dissection of the molecular mechanism of action of GW5638, a novel estrogen receptor ligand, provides insights into the role of estrogen receptor in bone.
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Distinct properties of cell-type-specific and shared transcription factor binding sites.
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Do estrogen or selective estrogen receptor modulators improve quality of life for women with postmenopausal osteoporosis?
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EZH2 regulates the transcription of estrogen-responsive genes through association with REA, an estrogen receptor corepressor.
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Effect of an intrauterine contraceptive device on uterine motility in the rat.
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Effect of exogenous dehydroepiandrosterone upon the fetoplacental biosynthesis of estrogens and its effect upon uterine blood flow in the term pregnant ewe.
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Effects of an oral contraceptive combination with or without androgen on mammary tissues: a study in rats.
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Effects of atrial natriuretic peptide on rat ovarian granulosa cell steroidogenesis in vitro.
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Effects of cytokines on porcine granulosa cell steroidogenesis in vitro.
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Effects of long-term estrogen replacement therapy. I. Metabolic effects.
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Effects of long-term estrogen replacement therapy. II. Neoplasia.
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Effects of risk factors for ovarian cancer in women with and without endometriosis.
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Endocrine Screening Methods Workshop report: detection of estrogenic and androgenic hormonal and antihormonal activity for chemicals that act via receptor or steroidogenic enzyme mechanisms.
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Endocrine therapy in metastatic breast cancer.
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Endometrial hyperplasia risk in relation to recent use of oral contraceptives and hormone therapy.
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Endometrial receptivity and implantation require uterine BMP signaling through an ACVR2A-SMAD1/SMAD5 axis.
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Endometriosis, in vitro fertilisation and the risk of gynaecological malignancies, including ovarian and breast cancer.
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Environmental estrogens differentially engage the histone methyltransferase EZH2 to increase risk of uterine tumorigenesis.
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Environmentally relevant xenoestrogen tissue concentrations correlated to biological responses in mice.
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Eosinophilia in cancer and its regulation by sex hormones.
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Epithelial progesterone receptor exhibits pleiotropic roles in uterine development and function.
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Estradiol replacement therapy regulates innate immune response in ovariectomized arthritic mice.
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Estrogen Receptor Signaling in the Immune System.
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Estrogen and progesterone production by developing porcine follicles in vitro: evidence for estrogen formation by theca.
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Estrogen and progesterone production by granulosa cell monolayers derived from in vitro fertilization procedures: lack of evidence for modulation by androgen.
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Estrogen and sex-dependent loss of the vocal learning system in female zebra finches.
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Estrogen and thyroid hormone interaction on regulation of gene expression.
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Estrogen bioactivation, genetic polymorphisms, and ovarian cancer.
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Estrogen effects on cognition across the lifespan.
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Estrogen induction of ovalbumin mRNA: evidence for transcription control.
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Estrogen levels in childhood determined by an ultrasensitive recombinant cell bioassay.
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Estrogen mediates inflammatory role of mast cells in endometriosis pathophysiology.
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Estrogen mediates neuroprotection and anti-inflammatory effects during EAE through ERα signaling on astrocytes but not through ERβ signaling on astrocytes or neurons.
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Estrogen metabolism within the lung and its modulation by tobacco smoke.
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Estrogen pathway polymorphisms in relation to primary open angle glaucoma: an analysis accounting for gender from the United States.
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Estrogen production and metabolism in endometriosis.
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Estrogen protects against intracranial aneurysm rupture in ovariectomized mice.
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Estrogen receptor (ER) modulators each induce distinct conformational changes in ER alpha and ER beta.
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Estrogen receptor gene disruption: molecular characterization and experimental and clinical phenotypes.
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Estrogen receptor-cofactor interactions as targets for novel drug discovery.
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Estrogen regulation of aquaporins in the mouse uterus: potential roles in uterine water movement.
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Estrogen represses SOX9 during sex determination in the red-eared slider turtle Trachemys scripta.
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Estrogen treatment enhances hereditary renal tumor development in Eker rats.
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Estrogen, estrogen plus progestin therapy, and risk of breast cancer.
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Estrogen-induced mitogenesis of MCF-7 cells does not require the induction of mitogen-activated protein kinase activity.
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Estrogen-mediated epigenetic repression of large chromosomal regions through DNA looping.
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Estrogen-regulated feedback loop limits the efficacy of estrogen receptor-targeted breast cancer therapy.
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Estrogen/progesterone receptor and HER2 discordance between primary tumor and brain metastases in breast cancer and its effect on treatment and survival.
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Estrogenic ovulatory dysfunction or functional female hyperandrogenism: an argument to discard the term polycystic ovary syndrome.
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Estrogenic responses of larval sunshine bass (Morone saxatilis x M. Chrysops) exposed to New York City sewage effluent.
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Estrogens and prostate cancer.
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Exome sequencing identifies highly recurrent MED12 somatic mutations in breast fibroadenoma.
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Expression of ectopic heat shock protein 90 in male and female primary afferent nociceptors regulates inflammatory pain.
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Female gender, estrogen loss, and Sub-RPE deposit formation in aged mice.
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Female steroid hormones and target cell nuclei.
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Female steroid hormones use signal transducers and activators of transcription protein-mediated pathways to modulate the expression of T-bet in epithelial cells: a mechanism for local immune regulation in the human reproductive tract.
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Follicular development, acquisition of mature oocytes, and pregnancy after 2 weeks of leuprolide acetate administration during the midluteal phase.
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Galanin is an estrogen-inducible, secretory product of the rat anterior pituitary.
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Gender and estrogen supplementation increases severity of experimental choroidal neovascularization.
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Gender differences in cholesterol nucleation in native bile: estrogen is a potential contributory factor.
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Gene expression profiling of breast cancer in relation to estrogen receptor status and estrogen-metabolizing enzymes: clinical implications.
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Granulosa cell differentiation in vitro: effect of insulin on growth and functional integrity.
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Heart hypertrophy during pregnancy: a better functioning heart?
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Hematology reference intervals for transgender adults on stable hormone therapy.
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Hepatic dysfunction following busulfan and cyclophosphamide myeloablation: a retrospective, multicenter analysis.
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High level expression of biologically active estrogen receptor in Saccharomyces cerevisiae.
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Histopathologic distinctions in the relationship of estrogens and endometrial cancer.
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Homeostasis imbalance in the endometrium of women with implantation defects: the role of estrogen and progesterone.
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Hormonal and personal effects on estrogen receptors in breast cancer.
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Hormonal and reproductive risk factors for development of systemic lupus erythematosus: results of a population-based, case-control study.
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Hormonal control of oviduct growth and differentiation.
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Hormonal management of menopausal symptoms in women with a history of gynecologic malignancy.
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Hormonal, environmental, and infectious risk factors for developing systemic lupus erythematosus.
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Hormone control and expression of androgen receptor coregulator MAGE-11 in human endometrium during the window of receptivity to embryo implantation.
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Hormone receptor activities of complex mixtures of known and suspect chemicals in personal silicone wristband samplers worn in office buildings.
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Hormone signaling and fatty liver in females: analysis of estrogen receptor α mutant mice.
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Hormone therapy: physiological complexity belies therapeutic simplicity.
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Hyperprogesteronemia in response to Vitex fischeri consumption in wild chimpanzees (Pan troglodytes schweinfurthii).
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Hypothalamic insufficiency: the cause of hypopituitarism in sarcoidosis.
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Identification of Estrogen Signaling in a Prioritization Study of Intraocular Pressure-Associated Genes.
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Identification of resting cells by dual-parameter flow cytometry of statin expression and DNA content.
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Immunological approach to the study of hormone action: regulation of the phosphorylation state of protein phosphatase inhibitor-1 by hormones.
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Impact of gene variants on sex-specific regulation of human Scavenger receptor class B type 1 (SR-BI) expression in liver and association with lipid levels in a population-based study.
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Impact of progestin and estrogen potency in oral contraceptives on ovarian cancer risk.
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Implanted estrogen pellets associated with hypertriglyceridemia, biliary dyskinesia and focal nodular hyperplasia of the liver: a case report.
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In situ distinction between steroid receptor binding and transactivation at a target gene.
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Increased Ca2+ signaling through CaV1.2 promotes bone formation and prevents estrogen deficiency-induced bone loss.
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Indian hedgehog as a progesterone-responsive factor mediating epithelial-mesenchymal interactions in the mouse uterus.
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Influence of the Gastrointestinal Environment on the Bioavailability of Ethinyl Estradiol Sorbed to Single-Walled Carbon Nanotubes.
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Inhibition of estrogen signaling in myeloid cells increases tumor immunity in melanoma.
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Inhibition of mitogen-activated protein kinase and phosphatidylinositol 3-kinase activity in MCF-7 cells prevents estrogen-induced mitogenesis.
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Integrating the female masculinization and challenge hypotheses: Female dominance, male deference, and seasonal hormone fluctuations in adult blue-eyed black lemurs (Eulemur flavifrons).
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Interaction of estrogen receptor alpha with protein kinase C alpha and c-Src in osteoblasts during differentiation.
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Inverse association of female hormone replacement therapy with age-related macular degeneration and interactions with ARMS2 polymorphisms.
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Investigation of antiestrogenic properties of unleaded gasoline in female mice.
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Lactoferrin gene expression is estrogen responsive in human and rhesus monkey endometrium.
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Life-history correlates of steroid concentrations in wild peripartum baboons.
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Loss of epithelial oestrogen receptor α inhibits oestrogen-stimulated prostate proliferation and squamous metaplasia via in vivo tissue selective knockout models.
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Lower-dose vs high-dose oral estradiol therapy of hormone receptor-positive, aromatase inhibitor-resistant advanced breast cancer: a phase 2 randomized study.
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Management of Menopausal Symptoms for Women Who Are at High Risk of Thrombosis.
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Measuring fecal testosterone in females and fecal estrogens in males: comparison of RIA and LC/MS/MS methods for wild baboons (Papio cynocephalus).
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Mechanisms of excessive estrogen formation in endometriosis.
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Mechanisms of sexual selection: sexual swellings and estrogen concentrations as fertility indicators and cues for male consort decisions in wild baboons.
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Menopausal hormones and risk of ovarian cancer.
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Menstrual cycle effects on caffeine elimination in the human female.
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Mig-6 modulates uterine steroid hormone responsiveness and exhibits altered expression in endometrial disease.
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Mining the complexities of the estrogen signaling pathways for novel therapeutics.
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Mitochondrial Quality Control as a Therapeutic Target.
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Molecular and functional signature of heart hypertrophy during pregnancy.
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Molecular cloning of the cDNA and promoter sequences for the mouse sodium-hydrogen exchanger regulatory factor.
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Monitoring the randomized trials of the Women's Health Initiative: the experience of the Data and Safety Monitoring Board.
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Multimodal therapy of prostatic cancer.
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Multiple drug chemotherapy regimen for patients with hormonally-unresponsive carcinoma of the prostate: a preliminary report.
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Necropsy diagnosis of endometrial cancer and detection-bias in case/control studies.
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Nonpharmacologic and pharmacologic treatment of patients with low levels of high-density lipoprotein cholesterol.
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Oestrogen and progesterone action on endometrium: a translational approach to understanding endometrial receptivity.
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Oestrogen shuts the door on SOX9.
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Organization of the human aromatase p450 (CYP19) gene.
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Osteoporosis.
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Ovalbumin messenger RNA of chick oviduct: partial characterization, estrogen dependence, and translation in vitro.
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Patient receipt and understanding of written information provided with isotretinoin and estrogen prescriptions.
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Peptidyl-prolyl isomerase 1 (Pin1) serves as a coactivator of steroid receptor by regulating the activity of phosphorylated steroid receptor coactivator 3 (SRC-3/AIB1).
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Phenol sulfotransferases: hormonal regulation, polymorphism, and age of onset of breast cancer.
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Phytochemical mimicry of reproductive hormones and modulation of herbivore fertility by phytoestrogens.
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Platelet-derived growth factor in fibrous musculoskeletal disorders: a study of pathologic tissue sections and in vitro primary cell cultures.
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Poor Endometrial Proliferation After Clomiphene is Associated With Altered Estrogen Action.
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Prenatal cocaine eliminates the sex-dependent differences in activation observed in adult rats after cocaine challenge.
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Proceedings: Hormonal control of steroid synthesis by a feminizing adrenal tumour.
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Proceedings: Measurement of endogenous steroid levels in human breast tumours by mass fragmentography.
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Production of progestin-stimulatory factor(s) by enriched populations of rat T and B lymphocytes.
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Progesterone Signaling in Endometrial Epithelial Organoids.
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Progesterone inhibits glucocorticoid-induced murine thymocyte apoptosis.
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Progesterone receptor membrane component 1: is metabolism integral to its function and what other steroids are involved?
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Progestin and estrogen potency of combination oral contraceptives and endometrial cancer risk.
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Prostaglandin F 2 alpha production by the human ovary.
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Prostaglandin F2alpha levels in human ovarian plasma in pregnancy and in a case of Halban's disease.
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Psychometric properties of a tool for measuring hormone-related symptoms in breast cancer survivors.
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Race, Menopausal Hormone Therapy, and Invasive Breast Cancer in the Carolina Breast Cancer Study.
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Receptor interconversion model of hormone action. 2. Requirement of both kinase and phosphatase activities for conferring estrogen binding activity to the estrogen receptor.
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Regulation of lipoprotein synthesis. Studies on the molecular mechanisms of lipoprotein synthesis and their regulation by estrogen in the cockerel.
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Reproductive Endocrinology Reference Intervals for Transgender Men on Stable Hormone Therapy.
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Reproductive and general metabolic effects of phytoestrogens in mammals.
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Requirement of estrogen receptor alpha DNA-binding domain for HPV oncogene-induced cervical carcinogenesis in mice.
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Responses to olfactory stimuli in spotted hyenas (Crocuta crocuta): II. Discrimination of conspecific scent
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Risk of complex and atypical endometrial hyperplasia in relation to anthropometric measures and reproductive history.
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Risk of exogenous estrogen therapy and endometrial cancer.
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Role of aromatase in endometrial disease.
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Roles of estrogen in the formation of intracranial aneurysms in ovariectomized female mice.
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Self-renewing endometrial epithelial organoids of the human uterus.
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Sex Hormone Relations to Histologic Severity of Pediatric Nonalcoholic Fatty Liver Disease.
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Sex hormones, acting on the TERT gene, increase telomerase activity in human primary hematopoietic cells.
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Sex steroids, APOE genotype and the innate immune system.
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Sex-related differences in clinical drug response: Implications for women's health
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Sex-related differences in clinical outcomes among patients with myocardial infarction with nonobstructive coronary artery disease: A systematic review and meta-analysis.
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Sexual function in women with urinary incontinence and pelvic organ prolapse.
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Spotted hyaenas and the sexual spectrum: reproductive endocrinology and development.
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Steroid hormone induction of a specific translatable messenger RNA.
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Steroid hormone regulation of specific gene expression.
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Steroid hormone regulation of specific messenger RNA and protein synthesis in eucaryotic cells.
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Steroid hormones drive cancer development.
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Steroid structural requirements for high affinity binding to human sex steroid binding protein (SBP).
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Steroidal modulation of steroid secretion in vitro: an experimental approach to intra-follicular regulatory mechanisms.
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Steroidogenesis in porcine atretic follicles: loss of aromatase activity in isolated granulosa and theca.
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Structural organization and regulation of the chicken estrogen receptor.
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Synthesis of very low density lipoproteins in the cockerel. Effects of estrogen.
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Temperature, genes, and sex: a comparative view of sex determination in Trachemys scripta and Mus musculus.
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The Alzheimer's Disease Assessment Scale: patterns and predictors of baseline cognitive performance in multicenter Alzheimer's disease trials.
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The Development of Prostate Adenocarcinoma in a Transgender Male to Female Patient: Could Estrogen Therapy Have Played a Role?
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The Estrogen Receptor α Cistrome in Human Endometrium and Epithelial Organoids.
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The G protein-coupled receptor GPR30 inhibits proliferation of estrogen receptor-positive breast cancer cells.
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The Impact of Endometriosis across the Lifespan of Women: Foreseeable Research and Therapeutic Prospects.
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The Urinary Microbiome in Postmenopausal Women with Recurrent Urinary Tract Infections.
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The clinical spectrum of prostate cancer.
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The dehydroepiandrosterone loading test. III. A possible placental function test.
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The dehydroepiandrosterone loading test. IV. Evaluation of clinical utility.
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The development and stability of estrogen-modulated spatial navigation strategies in female rats.
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The dual ErbB1/ErbB2 inhibitor, lapatinib (GW572016), cooperates with tamoxifen to inhibit both cell proliferation- and estrogen-dependent gene expression in antiestrogen-resistant breast cancer.
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The endocrinology of pregnancy and fetal loss in wild baboons.
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The estrogen receptor beta-isoform (ERbeta) of the human estrogen receptor modulates ERalpha transcriptional activity and is a key regulator of the cellular response to estrogens and antiestrogens.
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The impact of endocrine therapy on sexual dysfunction in postmenopausal women with early stage breast cancer: encouraging results from a prospective study.
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The mechanism of steroid-hormone regulation of transcription of specific eukaryotic genes.
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The menstrual cycle in context, II: Human gonadal steroid hormone variability
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The molecular mechanisms underlying the pharmacological actions of estrogens, SERMs and oxysterols: implications for the treatment and prevention of osteoporosis.
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The molecular pharmacology of ovarian steroid receptors.
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The nonhuman primate model of the relationship between gonadal steroids and coronary heart disease.
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The pathologic features and behavior of endometrial carcinoma associated with exogenous estrogen administration.
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The prediction and/or detection of ovulation by means of urinary steroid assays.
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The timing of the "fertile window" in the menstrual cycle: day specific estimates from a prospective study.
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Therapeutic implications of estrogen for cerebral vasospasm and delayed cerebral ischemia induced by aneurysmal subarachnoid hemorrhage.
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Toxicology of environmental estrogens.
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Toy story: why do monkey and human males prefer trucks? Comment on "Sex differences in rhesus monkey toy preferences parallel those of children" by Hassett, Siebert and Wallen.
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Transcription profiling of estrogen target genes in young and old mouse uterus.
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Transdermal versus oral estrogen therapy in postmenopausal smokers: hemodynamic and endothelial effects.
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Transforming growth factor beta mediates the estrogen induced inhibition of UMR106 cell growth.
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Transgender women on oral HIV pre-exposure prophylaxis have significantly lower tenofovir and emtricitabine concentrations when also taking oestrogen when compared to cisgender men.
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Tumor Cell-Independent Estrogen Signaling Drives Disease Progression through Mobilization of Myeloid-Derived Suppressor Cells.
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Update on Alzheimer's disease. Promising advances in detection and treatment.
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Use of alternative therapies in menopause.
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Vaginal rugae: measurement and significance.
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Vasomotor symptoms, serum estrogens, and gonadotropin levels in surgical menopause.
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Women's Health Initiative clinical trials: potential interactive effect of calcium and vitamin D supplementation with hormonal therapy on cardiovascular disease.
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Working group on noncoronary cardiovascular disease and exercise in women.
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p38α MAPK Regulates Lineage Commitment and OPG Synthesis of Bone Marrow Stromal Cells to Prevent Bone Loss under Physiological and Pathological Conditions.
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Keywords of People
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Berchuck, Andrew,
James M. Ingram Distinguished Professor of Gynecologic Oncology,
Obstetrics and Gynecology, Gynecologic Oncology
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Liu, Yutao,
Adjunct Assistant Professor in the Department of Medicine,
Medicine, Medical Genetics
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McDonnell, Donald Patrick,
Glaxo-Wellcome Distinguished Professor of Molecular Cancer Biology, in the School of Medicine,
Cell Biology
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Moorman, Patricia Gripka,
Professor Emeritus in Family Medicine and Community Health,
Duke Cancer Institute