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Subject Areas on Research
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Absence of biochemical evidence for renal and hepatic dysfunction after 8 hours of 1.25 minimum alveolar concentration sevoflurane anesthesia in volunteers.
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Analysis of alkylphenol ethoxylate metabolites in the aquatic environment using liquid chromatography-electrospray mass spectrometry.
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Analysis of calcium homeostasis in activated human polymorphonuclear leukocytes. Evidence for two distinct mechanisms for lowering cytosolic calcium.
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Antimicrobial and bacteria-releasing multifunctional surfaces: oligo (p-phenylene-ethynylene)/poly (N-isopropylacrylamide) films deposited by RIR-MAPLE.
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Antimicrobial oligo(p-phenylene-ethynylene) film deposited by resonant infrared matrix-assisted pulsed laser evaporation.
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Application of ruthenium-induced macrocyclization for the construction of macrocyclic depsipeptides.
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Assessment of low-flow sevoflurane and isoflurane effects on renal function using sensitive markers of tubular toxicity.
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Biotransformation of L-cysteine S-conjugates and N-acetyl-L-cysteine S-conjugates of the sevoflurane degradation product fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether (compound A) in human kidney in vitro: interindividual variability in N-acetylation, N-deacetylation, and beta-lyase-catalyzed metabolism.
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Biotransformation of sevoflurane.
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Catalytic enantioselective alkylation of substituted dioxanone enol ethers: ready access to Calpha-tetrasubstituted hydroxyketones, acids, and esters.
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Clinical experience with substance P receptor (NK1) antagonists in depression.
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Clinical sevoflurane metabolism and disposition. I. Sevoflurane and metabolite pharmacokinetics.
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Clinical sevoflurane metabolism and disposition. II. The role of cytochrome P450 2E1 in fluoride and hexafluoroisopropanol formation.
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Comparative absorption and bioaccumulation of polybrominated diphenyl ethers following ingestion via dust and oil in male rats.
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Comparison of Amsorb, sodalime, and Baralyme degradation of volatile anesthetics and formation of carbon monoxide and compound a in swine in vivo.
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Compound A uptake and metabolism to mercapturic acids and 3,3,3-trifluoro-2-fluoromethoxypropanoic acid during low-flow sevoflurane anesthesia: biomarkers for exposure, risk assessment, and interspecies comparison.
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Cytotoxicity of S-conjugates of the sevoflurane degradation product fluoromethyl-2,2-difluoro-1-(trifluoromethyl) vinyl ether (Compound A) in a human proximal tubular cell line.
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Dietary accumulation and metabolism of polybrominated diphenyl ethers by juvenile carp (Cyprinus carpio).
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Dose-dependent metabolism of fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether (compound A), an anesthetic degradation product, to mercapturic acids and 3,3,3-trifluoro-2-(fluoromethoxy)propanoic acid in rats.
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Effect of sevoflurane on P50 and on measurement of oxygen tension.
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Effects of ether and thiopental on spinal presynaptic terminals.
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Evidence for metabolism of fluoromethyl 2,2-difluoro-1-(trifluoromethyl)vinyl ether (compound A), a sevoflurane degradation product, by cysteine conjugate beta-lyase.
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Gene expression profiling of nephrotoxicity from the sevoflurane degradation product fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether ("compound A") in rats.
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Glutathione S-conjugation of the sevoflurane degradation product, fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether (compound A) in human liver, kidney, and blood in vitro.
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Human kidney methoxyflurane and sevoflurane metabolism. Intrarenal fluoride production as a possible mechanism of methoxyflurane nephrotoxicity.
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Identification in rat bile of glutathione conjugates of fluoromethyl 2,2-difluoro-1-(trifluoromethyl)vinyl ether, a nephrotoxic degradate of the anesthetic agent sevoflurane.
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Identification of cytochrome P450 2E1 as the predominant enzyme catalyzing human liver microsomal defluorination of sevoflurane, isoflurane, and methoxyflurane.
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Local deformation behavior of surface porous polyether-ether-ketone.
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Long-duration low-flow sevoflurane and isoflurane effects on postoperative renal and hepatic function.
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Low-flow sevoflurane compared with low-flow isoflurane anesthesia in patients with stable renal insufficiency.
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Metabolism and toxicity of the new anesthetic agents.
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Modified extraction procedure for gas-liquid chromatography applied to the identification of anaerobic bacteria.
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Multiple calcium-mediated effector mechanisms regulate chloride secretory responses in T84-cells.
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Myocardial ischemia and adverse cardiac outcomes in cardiac patients undergoing noncardiac surgery with sevoflurane and isoflurane. Sevoflurane Ischemia Study Group.
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Nephrotoxicity of sevoflurane compound A [fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether] in rats: evidence for glutathione and cysteine conjugate formation and the role of renal cysteine conjugate beta-lyase.
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Nonionic Ethoxylated Surfactants Induce Adipogenesis in 3T3-L1 Cells.
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Origins of the helical wrapping of phenyleneethynylene polymers about single-walled carbon nanotubes.
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P450-dependent and nonenzymatic human liver microsomal defluorination of fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether (compound A), a sevoflurane degradation product.
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Pharmacovigilance and safety aspects of sevoflurane.
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Regio- and stereoselective synthesis of alkyl allylic ethers via gold(I)-catalyzed intermolecular hydroalkoxylation of allenes with alcohols.
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Regulation of inositol phosphate metabolism in chemoattractant-stimulated human polymorphonuclear leukocytes. Definition of distinct dephosphorylation pathways for IP3 isomers.
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Renal cysteine conjugate beta-lyase and compound A nephrotoxicity: minimal evidence for an association.
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Role of cytochrome P4503A in cysteine S-conjugates sulfoxidation and the nephrotoxicity of the sevoflurane degradation product fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether (compound A) in rats.
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Role of renal cysteine conjugate beta-lyase in the mechanism of compound A nephrotoxicity in rats.
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Role of the renal cysteine conjugate beta-lyase pathway in inhaled compound A nephrotoxicity in rats.
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Safety of low-flow sevoflurane anesthesia in patients with chronically impaired renal function is not proven.
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Serum levels of polybrominated diphenyl ethers (PBDEs) in foam recyclers and carpet installers working in the United States.
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Sevoflurane and halothane reduce focal ischemic brain damage in the rat. Possible influence on thermoregulation.
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Sevoflurane, fluoride ion, and renal toxicity.
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Spectrum and subcellular determinants of fluorinated anesthetic-mediated proximal tubular injury.
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Sulfoxidation of cysteine and mercapturic acid conjugates of the sevoflurane degradation product fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether (compound A).
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Supramolecular nanomimetics: replication of micelles, viruses, and other naturally occurring nanoscale objects.
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The hemodynamic and renal effects of sevoflurane and isoflurane in patients with coronary artery disease and chronic hypertension. Sevoflurane Ischemia Study Group.
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The regio- and stereospecific intermolecular dehydrative alkoxylation of allylic alcohols catalyzed by a gold(I) N-heterocyclic carbene complex.
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[Compound A: toxicology and clinical relevance].
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