Ethyl Methanesulfonate

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  Subject Areas on Research

  • Alpha-tocopheryl succinate protects hepatocytes from chemical-induced toxicity under physiological calcium conditions. 
  • Chromosomes with high gene density are preferentially repaired in human cells. 
  • Comparison of dose-response relationships for ethyl methanesulfonate and 1-ethyl-1-nitrosourea in Drosophila melanogaster spermatozoa. 
  • Elevated frequency of microsatellite mutations in TK6 human lymphoblast clones selected for mutations at the thymidine kinase locus. 
  • Evidence for coincident mutations in human lymphoblast clones selected for functional loss of a thymidine kinase gene. 
  • Identification of a negative regulatory function for steroid receptors. 
  • Ligand-binding residues integrate affinity and efficacy in the NMDA receptor. 
  • Localization of the activation gate for small conductance Ca2+-activated K+ channels. 
  • Molecular dosimetry of chemical mutagens. Determination of molecular dose to the germ line. 
  • Molecular dosimetry of the mutagen ethyl methanesulfonate in Drosophila melanogaster spermatozoa: linear relation of DNA alkylation per sperm cell (dose) to sex-linked recessive lethals. 
  • Molecular mechanisms of spontaneous and induced loss of heterozygosity in human cells in vitro. 
  • Projections of Drosophila multidendritic neurons in the central nervous system: links with peripheral dendrite morphology. 
  • The NMDA receptor M3 segment is a conserved transduction element coupling ligand binding to channel opening. 
  • Tn5-mediated bleomycin resistance in Escherichia coli requires the expression of host genes.