Exodeoxyribonucleases

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  Subject Areas on Research

  • A defined human system that supports bidirectional mismatch-provoked excision. 
  • A possible mechanism for exonuclease 1-independent eukaryotic mismatch repair. 
  • Amino acid changes in Xrs2p, Dun1p, and Rfa2p that remove the preferred targets of the ATM family of protein kinases do not affect DNA repair or telomere length in Saccharomyces cerevisiae. 
  • Analysis of the excision step in human DNA mismatch repair. 
  • BLM-DNA2-RPA-MRN and EXO1-BLM-RPA-MRN constitute two DNA end resection machineries for human DNA break repair. 
  • Bacteriophage T4 mutants hypersensitive to an antitumor agent that induces topoisomerase-DNA cleavage complexes. 
  • Bidirectional excision in methyl-directed mismatch repair. 
  • Biocatalytic microcontact printing. 
  • Chromosome aberrations resulting from double-strand DNA breaks at a naturally occurring yeast fragile site composed of inverted ty elements are independent of Mre11p and Sae2p. 
  • Clinical and molecular phenotype of Aicardi-Goutieres syndrome. 
  • Coupling of human DNA excision repair and the DNA damage checkpoint in a defined in vitro system. 
  • Cytoplasmic activation of GAF, an IFN-gamma-regulated DNA-binding factor. 
  • DNA nicks inflicted by restriction endonucleases are repaired by a RecA- and RecB-dependent pathway in Escherichia coli. 
  • Decreased meiotic intergenic recombination and increased meiosis I nondisjunction in exo1 mutants of Saccharomyces cerevisiae. 
  • Endonucleolytic function of MutLalpha in human mismatch repair. 
  • Enhancer-origin interaction in plasmid R6K involves a DNA loop mediated by initiator protein. 
  • Enzymatic polymerization of high molecular weight DNA amphiphiles that self-assemble into star-like micelles. 
  • Exonuclease 1 (EXO1) gene variation and melanoma risk. 
  • FAN1 mutations cause karyomegalic interstitial nephritis, linking chronic kidney failure to defective DNA damage repair. 
  • Fine-structure mapping of meiosis-specific double-strand DNA breaks at a recombination hotspot associated with an insertion of telomeric sequences upstream of the HIS4 locus in yeast. 
  • Genomic instability and endoreduplication triggered by RAD17 deletion. 
  • Genomic mismatch scanning: a new approach to genetic linkage mapping. 
  • Human exonuclease 1 and BLM helicase interact to resect DNA and initiate DNA repair. 
  • Human exonuclease I is required for 5' and 3' mismatch repair. 
  • Human mismatch repair: reconstitution of a nick-directed bidirectional reaction. 
  • Hydrolytic function of Exo1 in mammalian mismatch repair. 
  • In vivo requirement for RecJ, ExoVII, ExoI, and ExoX in methyl-directed mismatch repair. 
  • Interplay of catalysis, fidelity, threading, and processivity in the exo- and endonucleolytic reactions of human exonuclease I. 
  • Mechanism of 5'-directed excision in human mismatch repair. 
  • Mechanisms in eukaryotic mismatch repair. 
  • Mechanisms of DNA-mismatch correction. 
  • Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways. 
  • Mre11-Sae2 and RPA Collaborate to Prevent Palindromic Gene Amplification. 
  • Redundant exonuclease involvement in Escherichia coli methyl-directed mismatch repair. 
  • Regulation of hetDNA Length during Mitotic Double-Strand Break Repair in Yeast. 
  • Roles of exonucleases and translesion synthesis DNA polymerases during mitotic gap repair in yeast. 
  • Sensing and Processing of DNA Interstrand Crosslinks by the Mismatch Repair Pathway. 
  • Structural basis for the 3'-5' exonuclease activity of Escherichia coli DNA polymerase I: a two metal ion mechanism. 
  • Structure of the Rad50 x Mre11 DNA repair complex from Saccharomyces cerevisiae by electron microscopy. 
  • Structures of ParB bound to DNA reveal mechanism of partition complex formation. 
  • Structures of human exonuclease 1 DNA complexes suggest a unified mechanism for nuclease family. 
  • Synthesis of 5-substituted 2'-deoxycytidine 5'-(alpha-P-borano)triphosphates, their incorporationinto DNA and effects on exonuclease. 
  • The Mre11p/Rad50p/Xrs2p complex and the Tel1p function in a single pathway for telomere maintenance in yeast. 
  • The protein hSnm1B is stabilized when bound to the telomere-binding protein TRF2. 
  • The role of Exo1p exonuclease in DNA end resection to generate gene conversion tracts in Saccharomyces cerevisiae. 
  • Trex2 enables spontaneous sister chromatid exchanges without facilitating DNA double-strand break repair. 
  • hSnm1B is a novel telomere-associated protein. 
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  Keywords of People

  • Erickson, Harold Paul, James B. Duke Distinguished Professor of Cell Biology, Biomedical Engineering