Exonucleases

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  Subject Areas on Research

  • Bacteriophage T7 Deoxyribonucleic acid replication in vitro. A protein of Escherichia coli required for bacteriophage T7 DNA polymerase activity. 
  • Crystal structure of a pol alpha family DNA polymerase from the hyperthermophilic archaeon Thermococcus sp. 9 degrees N-7. 
  • Crystal structure of a thermostable Bacillus DNA polymerase I large fragment at 2.1 A resolution. 
  • Crystal structures of the Klenow fragment of DNA polymerase I complexed with deoxynucleoside triphosphate and pyrophosphate. 
  • Deoxyribonucleic acid ligase. A steady state kinetic analysis of the reaction catalyzed by the enzyme from Escherichia coli. 
  • Disruption of the Rad9/Rad1/Hus1 (9-1-1) complex leads to checkpoint signaling and replication defects. 
  • Functional Analysis of the Bacteriophage T4 Rad50 Homolog (gp46) Coiled-coil Domain. 
  • Genetic and crystallographic studies of the 3',5'-exonucleolytic site of DNA polymerase I. 
  • Human mismatch repair: reconstitution of a nick-directed bidirectional reaction. 
  • Hypermethylation of 14-3-3 sigma (stratifin) is an early event in breast cancer. 
  • Interaction between the T4 helicase-loading protein (gp59) and the DNA polymerase (gp43): a locking mechanism to delay replication during replisome assembly. 
  • Methyl-directed mismatch repair is bidirectional. 
  • Mismatch repair proteins and mitotic genome stability. 
  • Multiple and specific initiation of T4 DNA replication. 
  • On the role of deoxyribonucleic acid polymerase in determining mutation rates. Characterization of the defect in the T4 deoxyribonucleic acid polymerase caused by the ts L88 mutation. 
  • Potentially functional polymorphisms of EXO1 and risk of lung cancer in a Chinese population: A case-control analysis. 
  • T7-induced DNA polymerase. Characterization of associated exonuclease activities and resolution into biologically active subunits.