Exploratory Behavior

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  Subject Areas on Research

  • 5-HT2C Agonists Modulate Schizophrenia-Like Behaviors in Mice. 
  • A Primer on Foraging and the Explore/Exploit Trade-Off for Psychiatry Research. 
  • A preliminary analysis of interactions between genotype, retrospective ADHD symptoms, and initial reactions to smoking in a sample of young adults. 
  • A single high dose of cocaine induces differential sensitization to specific behaviors across adolescence. 
  • Active and explorative individuals are often restless and excluded from studies measuring resting metabolic rate: Do alternative metabolic rate measures offer a solution? 
  • Active tactile exploration influences the functional maturation of the somatosensory system. 
  • Age-related declines in exploratory behavior and markers of hippocampal plasticity are attenuated by prenatal choline supplementation in rats. 
  • Age-related preservation of top-down attentional guidance during visual search. 
  • Altered ultrasonic vocalization and impaired learning and memory in Angelman syndrome mouse model with a large maternal deletion from Ube3a to Gabrb3. 
  • Animals lacking endothelin-converting enzyme-2 are deficient in learning and memory. 
  • Anxiolytic effects of nicotine in zebrafish. 
  • Apolipoprotein E expression and behavioral toxicity of high charge, high energy (HZE) particle radiation. 
  • Approach and exploration of a novel alternative by 12-month-old infants. 
  • Associations between temperament and DSM-IV externalizing disorders in children and adolescents. 
  • Attack cone avoidance during predator inspection visits by wild finescale dace (Phoxinus neogaeus): the effects of predator diet. 
  • Axonal regrowth after spinal cord injury via chondroitinase and the tissue plasminogen activator (tPA)/plasmin system. 
  • Bacterial infection early in life protects against stressor-induced depressive-like symptoms in adult rats. 
  • Behavioral and circuit basis of sucrose rejection by Drosophila females in a simple decision-making task. 
  • Behavioral effects of developmental lead exposure in rhesus monkeys. 
  • Behavioral profiling of multiple pairs of rats selectively bred for high and low alcohol intake using the MCSF test. 
  • Branched-chain amino acids alter neurobehavioral function in rats. 
  • Brief report: Circumscribed attention in young children with autism. 
  • Buspirone, chlordiazepoxide and diazepam effects in a zebrafish model of anxiety. 
  • Catechol O-methyltransferase val158met genotype and neural mechanisms related to affective arousal and regulation. 
  • Catechol-O-methyltransferase inhibition alters pain and anxiety-related volitional behaviors through activation of β-adrenergic receptors in the rat. 
  • Causal evidence of performance monitoring by neurons in posterior cingulate cortex during learning. 
  • Cognition in animals: learning as program assembly. 
  • Combined exposure to tobacco smoke and ethanol during adolescence leads to short- and long-term modulation of anxiety-like behavior. 
  • Comt1 genotype and expression predicts anxiety and nociceptive sensitivity in inbred strains of mice. 
  • Critical developmental periods for effects of low-level tobacco smoke exposure on behavioral performance. 
  • Development of a computer-based behavioral assessment of checking behavior in obsessive-compulsive disorder. 
  • Developmental diazinon neurotoxicity in rats: later effects on emotional response. 
  • Developmental exposure to a complex PAH mixture causes persistent behavioral effects in naive Fundulus heteroclitus (killifish) but not in a population of PAH-adapted killifish. 
  • Developmental exposure to organophosphate flame retardants causes behavioral effects in larval and adult zebrafish. 
  • Developmental strategies in the analysis of ingestive behavior. 
  • Disruption of Arp2/3 results in asymmetric structural plasticity of dendritic spines and progressive synaptic and behavioral abnormalities. 
  • Dopamine D1 receptors and phosphorylation of dopamine- and cyclic AMP-regulated phosphoprotein-32 in the medial preoptic area are involved in experience-induced enhancement of male sexual behavior in rats. 
  • Dopaminergic control of sleep-wake states. 
  • Early ethanol consumption predicts relapse-like behavior in adolescent male rats. 
  • Effects of nicotine on novelty detection and memory recognition performance: double-blind, placebo-controlled studies of smokers and nonsmokers. 
  • Effects of periadolescent versus adult cocaine exposure on cocaine conditioned place preference and motor sensitization in mice. 
  • Effects on blood pressure and exploratory behaviour of mice lacking angiotensin II type-2 receptor. 
  • Emergence of anxiety-like behaviours in depressive-like Cpe(fat/fat) mice. 
  • Emotional curiosity: modulation of visuospatial attention by arousal is preserved in aging and early-stage Alzheimer's disease. 
  • Environmental effects on the ontogeny of exploratory and escape behaviors of Mongolian gerbils. 
  • Environmental enrichment has minimal effects on behavior in the Shank3 complete knockout model of autism spectrum disorder. 
  • Estradiol replacement enhances cocaine-stimulated locomotion in female C57BL/6 mice through estrogen receptor alpha. 
  • Facets of openness predict mortality in patients with cardiac disease. 
  • Familiar social and nonsocial stimuli and the kitten's response to a strange environment. 
  • Genome-wide activity-dependent MeCP2 phosphorylation regulates nervous system development and function. 
  • Ghrelin enhances olfactory sensitivity and exploratory sniffing in rodents and humans. 
  • Hippocampal networks habituate as novelty accumulates. 
  • Human apoE targeted replacement mouse lines: h-apoE4 and h-apoE3 mice differ on spatial memory performance and avoidance behavior. 
  • Hyperdopaminergia and NMDA receptor hypofunction disrupt neural phase signaling. 
  • Increased hypothermic responses to ethanol in rats selectively bred for cholinergic supersensitivity. 
  • Individual differences in novelty-seeking behavior but not in anxiety response to a new environment can predict nicotine consumption in adolescent C57BL/6 mice. 
  • Influence of L-triiodothyronine on memory following repeated electroconvulsive shock in rats: implications for human electroconvulsive therapy. 
  • Interactive effects of D1 and D2 agonists with scopolamine on radial-arm maze performance. 
  • Local knockdown of genes in the brain using small interfering RNA: a phenotypic comparison with knockout animals. 
  • Long-term behavioral assessment of guinea pigs following neonatal pneumoperitoneum. 
  • Long-term effects of acute and of chronic hypoxia on behavior and on hippocampal histology in the developing brain. 
  • Long-term effects of excitatory amino acid antagonists NBQX and MK-801 on the developing brain. 
  • Low-dose mecamylamine improves learning of rats in the radial-arm maze repeated acquisition procedure. 
  • MeCP2 phosphorylation limits psychostimulant-induced behavioral and neuronal plasticity. 
  • Microglia and memory: modulation by early-life infection. 
  • Middle-aged human apoE4 targeted-replacement mice show retention deficits on a wide range of spatial memory tasks. 
  • Motivational valence alters memory formation without altering exploration of a real-life spatial environment. 
  • Mouse handling limits the impact of stress on metabolic endpoints. 
  • Neuroanatomical and behavioral deficits in mice haploinsufficient for Pericentriolar material 1 (Pcm1). 
  • Neurobehavioral impairments caused by developmental imidacloprid exposure in zebrafish. 
  • Neurobehavioral toxicology of halothane in rats. 
  • Neuronal basis of sequential foraging decisions in a patchy environment. 
  • Neurophenotyping genetically modified mice for social behavior. 
  • Neurotoxicity of FireMaster 550® in zebrafish (Danio rerio): Chronic developmental and acute adolescent exposures. 
  • New modules are added to vibrissal premotor circuitry with the emergence of exploratory whisking. 
  • Nigrostriatal bundle damage and the lateral hypothalamic syndrome. 
  • Nitrous oxide does not alter infarct volume in rats undergoing reversible middle cerebral artery occlusion. 
  • Novel E815K knock-in mouse model of alternating hemiplegia of childhood. 
  • Novelty seeking and stereotypic activation of behavior in mice with disruption of the Dat1 gene. 
  • Novelty seeking and the dopamine D4 receptor gene (DRD4) revisited in Asians: haplotype characterization and relevance of the 2-repeat allele. 
  • Persistent behavioral alterations in rats neonatally exposed to low doses of the organophosphate pesticide, parathion. 
  • Persistent behavioral effects following early life exposure to retinoic acid or valproic acid in zebrafish. 
  • Persisting behavioral consequences of prenatal domoic acid exposure in rats. 
  • Plasticity of directional place fields in a model of rodent CA3. 
  • Potential neuroprotective effects of continuous topiramate therapy in the developing brain. 
  • Pre- and postnatal dietary protein deficiency influences anxiety, memory and social behaviour in the African striped mouse Rhabdomys dilectus chakae. 
  • Pre-treatment measures of impulsivity, aggression and sensation seeking are associated with treatment outcome for African-American cocaine-dependent patients. 
  • Preclinical drug trials in the mdx mouse: assessment of reliable and sensitive outcome measures. 
  • Predictors of exposure from an antimarijuana media campaign: outcome research assessing sensation seeking targeting. 
  • Prenatal choline availability modulates hippocampal neurogenesis and neurogenic responses to enriching experiences in adult female rats. 
  • Prenatal ethanol exposure in rats does not alter maze exploration or impair visual discrimination with or without distracting stimuli. 
  • Primary blast injury causes cognitive impairments and hippocampal circuit alterations. 
  • ProSAAS-derived peptides are regulated by cocaine and are required for sensitization to the locomotor effects of cocaine. 
  • Protein kinase C inhibition by tamoxifen antagonizes manic-like behavior in rats: implications for the development of novel therapeutics for bipolar disorder. 
  • Psychosocial correlates of job strain in a sample of working women. 
  • Purposive behavior and cognitive mapping: a neural network model. 
  • Reduced cortical BDNF expression and aberrant memory in Carf knock-out mice. 
  • Restoring striatal WAVE-1 improves maze exploration performance of GluN1 knockdown mice. 
  • Role of residual olfactory cues in the determination of feeding site selection and exploration patterns of domestic rats. 
  • SUN1/2 and Syne/Nesprin-1/2 complexes connect centrosome to the nucleus during neurogenesis and neuronal migration in mice. 
  • Searching from the top down: ageing and attentional guidance during singleton detection. 
  • Serotonin transporter polymorphisms and measures of impulsivity, aggression, and sensation seeking among African-American cocaine-dependent individuals. 
  • Smoking and the bandit: a preliminary study of smoker and nonsmoker differences in exploratory behavior measured with a multiarmed bandit task. 
  • Smoking automaticity and tolerance moderate brain activation during explore-exploit behavior. 
  • Social context affects how rhesus monkeys explore their environment. 
  • Suboptimal foraging behavior: a new perspective on gambling. 
  • Television campaigns and adolescent marijuana use: tests of sensation seeking targeting. 
  • The Three Cs of a Scientific Autobiography: Curiosity, Circumstance, and Colleagues. 
  • The fat mass and obesity associated gene (Fto) regulates activity of the dopaminergic midbrain circuitry. 
  • The functional anatomy of limbic status epilepticus in the rat. I. Patterns of 14C-2-deoxyglucose uptake and Fos immunocytochemistry. 
  • The functional significance of shyness in anorexia nervosa. 
  • The infant separates himself from his mother. 
  • The infant's free entry into a new environment. 
  • The influence of interpersonal interaction on diastolic blood pressure. 
  • Tobacco smoke containing high or low levels of nicotine during adolescence: effects on novelty-seeking and anxiety-like behaviors in mice. 
  • TrkB activation by 7, 8-dihydroxyflavone increases synapse AMPA subunits and ameliorates spatial memory deficits in a mouse model of Alzheimer's disease. 
  • Use of the light/dark test for anxiety in adult and adolescent male rats. 
  • Ventral striatal dopamine transporter availability is associated with lower trait motor impulsivity in healthy adults. 
  • Virtual active touch using randomly patterned intracortical microstimulation. 
  • Zebrafish assessment of cognitive improvement and anxiolysis: filling the gap between in vitro and rodent models for drug development. 
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  Keywords of People

  • Soderling, Scott Haydn, Professor in Cell Biology, Cell Biology
  • Warner, David Samuel, Distinguished Professor of Anesthesiology, in the School of Medicine, Neurobiology