Extracellular Matrix

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  Subject Areas on Research

  • (Pro)renin receptor is expressed in human retinal pigment epithelium and participates in extracellular matrix remodeling. 
  • 3-Dimensional spatially organized PEG-based hydrogels for an aortic valve co-culture model. 
  • ^* CRISPR-Based Epigenome Editing of Cytokine Receptors for the Promotion of Cell Survival and Tissue Deposition in Inflammatory Environments. 
  • A Heterotopic Xenograft Model of Human Airways for Investigating Fibrosis in Asthma. 
  • A Sensitized Screen for Genes Promoting Invadopodia Function In Vivo: CDC-42 and Rab GDI-1 Direct Distinct Aspects of Invadopodia Formation. 
  • A basement membrane discovery pipeline uncovers network complexity, regulators, and human disease associations. 
  • A biomechanical role for perlecan in the pericellular matrix of articular cartilage. 
  • A developmental biologist's "outside-the-cell" thinking. 
  • A new generation organ culture arising from cross-talk between multiple primary human cell types. 
  • A new hypothesis about the origin of uterine fibroids based on gene expression profiling with microarrays. 
  • A prospective, multicenter study to evaluate clinical and radiographic outcomes in primary rotator cuff repair reinforced with a xenograft dermal matrix. 
  • A six-armed oligomer isolated from cell surface fibronectin preparations. 
  • A synthetic matrix with independently tunable biochemistry and mechanical properties to study epithelial morphogenesis and EMT in a lung adenocarcinoma model. 
  • Abl kinases are required for invadopodia formation and chemokine-induced invasion. 
  • Abnormal extracellular material in the levator palpebrae superioris complex in congenital ptosis. 
  • Actions of thrombin in the interstitium. 
  • Activated lymphocytes promote endothelial cell detachment from matrix: a role for modulation of endothelial cell beta 1 integrin affinity. 
  • Adipocyte mesenchymal transition contributes to mammary tumor progression. 
  • Advances in Wound Management. 
  • Aligned multilayered electrospun scaffolds for rotator cuff tendon tissue engineering. 
  • Alterations in endothelial superoxide dismutase levels as a function of growth state in vitro. 
  • Altered wound healing in mice lacking a functional osteopontin gene (spp1). 
  • An immunoelectron microscope study of the aged human lens capsule. 
  • An off-the-shelf artificial cardiac patch improves cardiac repair after myocardial infarction in rats and pigs. 
  • Anchorage of VEGF to the extracellular matrix conveys differential signaling responses to endothelial cells 
  • Angiotensin II-induced hypertension regulates AT1 receptor subtypes and extracellular matrix turnover in mouse retinal pigment epithelium. 
  • Ankyrin-B interactions with spectrin and dynactin-4 are required for dystrophin-based protection of skeletal muscle from exercise injury. 
  • Articular chondrocyte tenascin-C production and assembly into de novo extracellular matrix. 
  • Aryl hydrocarbon receptor deficiency causes dysregulated cellular matrix metabolism and age-related macular degeneration-like pathology. 
  • Ascorbic acid promotes extracellular matrix deposition while preserving valve interstitial cell quiescence within 3D hydrogel scaffolds. 
  • B-LINK: a hemicentin, plakin, and integrin-dependent adhesion system that links tissues by connecting adjacent basement membranes. 
  • BCVS scientific conference 2012 meeting report. 
  • Balloon catheterization induced arterial expression of embryonic fibronectins. 
  • Basement Membranes in the Worm: A Dynamic Scaffolding that Instructs Cellular Behaviors and Shapes Tissues. 
  • Basement membrane remodeling guides cell migration and cell morphogenesis during development. 
  • Beta-catenin expression in Dupuytren's disease: potential role for cell-matrix interactions in modulating beta-catenin levels in vivo and in vitro. 
  • Biaxial Stretch Improves Elastic Fiber Maturation, Collagen Arrangement, and Mechanical Properties in Engineered Arteries 
  • Binding of hexabrachion (tenascin) to the extracellular matrix and substratum and its effect on cell adhesion. 
  • Binding of tenascin-C to soluble fibronectin and matrix fibrils. 
  • Biochemical and molecular homogeneity in the patellar tendon of the immature pig. 
  • Biochemical and structural studies of tenascin/hexabrachion proteins. 
  • Biological basis of bone formation, remodeling, and repair-part II: extracellular matrix. 
  • Biomarkers and proteomic analysis of osteoarthritis. 
  • Biomaterial-mediated retroviral gene transfer using self-assembled monolayers. 
  • Calcific Aortic Valve Disease: Part 2-Morphomechanical Abnormalities, Gene Reexpression, and Gender Effects on Ventricular Hypertrophy and Its Reversibility. 
  • Cancer-associated fibroblasts promote directional cancer cell migration by aligning fibronectin. 
  • Cartilage matrix remodelling differs by disease state and joint type. 
  • Cathepsin B is up-regulated and mediates extracellular matrix degradation in trabecular meshwork cells following phagocytic challenge. 
  • Ccn2a is an injury-induced matricellular factor that promotes cardiac regeneration in zebrafish. 
  • Cell and extracellular matrix growth theory and its implications for tumorigenesis. 
  • Cell migration through defined, synthetic ECM analogs. 
  • Cell polarity in sea urchin embryos: reorientation of cells occurs quickly in aggregates. 
  • Cellular functions of metallo-endoproteinases. 
  • Characterization of gelatinases linked to extracellular matrix invasion in ovarian adenocarcinoma: purification of matrix metalloproteinase 2. 
  • Chemokines have diverse abilities to form solid phase gradients. 
  • Chondrogenic differentiation of adipose-derived adult stem cells in agarose, alginate, and gelatin scaffolds. 
  • Chondrogenic differentiation of human embryonic stem cell-derived cells in arginine-glycine-aspartate-modified hydrogels. 
  • Chondroitin sulfate based niches for chondrogenic differentiation of mesenchymal stem cells. 
  • Cigarette smoke-related oxidants and the development of sub-RPE deposits in an experimental animal model of dry AMD. 
  • Citrullination of fibronectin alters integrin clustering and focal adhesion stability promoting stromal cell invasion. 
  • Cocultures of adult and juvenile chondrocytes compared with adult and juvenile chondral fragments: in vitro matrix production. 
  • Comparison of Cartilage Mechanical Properties Measured During Creep and Recovery. 
  • Comparison of plasminogen binding and activation on extracellular matrices produced by vascular smooth muscle and endothelial cells. 
  • Comprehensive Endogenous Tagging of Basement Membrane Components Reveals Dynamic Movement within the Matrix Scaffolding. 
  • Comprehensive Multi-omics Analysis Reveals Mitochondrial Stress as a Central Biological Hub for Spaceflight Impact. 
  • Control of Skeletal Muscle Cell Growth and Size Through Adhesion GPCRs. 
  • Control of basement membrane remodeling and epithelial branching morphogenesis in embryonic lung by Rho and cytoskeletal tension. 
  • Control of mesenchymal stem cell phenotype and differentiation depending on cell adhesion mechanism. 
  • Control of stem cell fate by physical interactions with the extracellular matrix. 
  • Controlling the kinetics of thiol-maleimide Michael-type addition gelation kinetics for the generation of homogenous poly (ethylene glycol) hydrogels 
  • Correlation between heart valve interstitial cell stiffness and transvalvular pressure: implications for collagen biosynthesis. 
  • Current technology for the derivation of pluripotent stem cell lines from human embryos. 
  • Decellularized native and engineered arterial scaffolds for transplantation. 
  • Decellularized tissue-engineered blood vessel as an arterial conduit. 
  • Design and characterization of poly(ethylene glycol) photopolymerizable semi-interpenetrating networks for chondrogenesis of human mesenchymal stem cells. 
  • Design of cell–matrix interactions in hyaluronic acid hydrogel scaffolds 
  • Development of a YIGSR-peptide-modified polyurethaneurea to enhance endothelialization. 
  • Development of the lipid-rich core in human atherosclerosis. 
  • Diastolic filling vortex forces and cardiac adaptations: probing the epigenetic nexus. 
  • Diet-induced obesity differentially regulates behavioral, biomechanical, and molecular risk factors for osteoarthritis in mice. 
  • Differential expression of galectin-1 and its interactions with cells and laminins in the intervertebral disc. 
  • Direct-contact co-culture between smooth muscle and endothelial cells inhibits TNF-alpha-mediated endothelial cell activation. 
  • Drebrin regulates angiotensin II-induced aortic remodelling. 
  • Dual labeling of the fibronectin matrix and actin cytoskeleton with green fluorescent protein variants. 
  • Dynamic Ligand Presentation in Biomaterials. 
  • Dynamic reciprocity between cells and their microenvironment in reproduction. 
  • Dynamics and elasticity of the fibronectin matrix in living cell culture visualized by fibronectin-green fluorescent protein. 
  • ECM production of primary human and bovine chondrocytes in hybrid PEG hydrogels containing type I collagen and hyaluronic acid. 
  • Early metabolite levels predict long-term matrix accumulation for chondrocytes in elastin-like polypeptide biopolymer scaffolds. 
  • Echinonectin: a new embryonic substrate adhesion protein. 
  • Effective boundary conditions for syncytial tissues. 
  • Effects of Copper and Cross-Linking on the Extracellular Matrix of Tissue-Engineered Arteries. 
  • Effects of cholesterol-lowering statins on the aqueous humor outflow pathway. 
  • Effects of copper and cross-linking on the extracellular matrix of tissue-engineered arteries. 
  • Effects of elevated intraocular pressure on outflow facility and TIGR/MYOC expression in perfused human anterior segments. 
  • Effects of epidermal growth factor on fibroblast migration through biomimetic hydrogels. 
  • Efficient transdifferentiation of human dermal fibroblasts into skeletal muscle. 
  • Electrospun cartilage-derived matrix scaffolds for cartilage tissue engineering. 
  • Elucidating the role of plexin D1 in body fat distribution and susceptibility to metabolic disease using a zebrafish model system. 
  • Endogenous presenilin 1 redistributes to the surface of lamellipodia upon adhesion of Jurkat cells to a collagen matrix. 
  • Engineering cell-material interfaces for long-term expansion of human pluripotent stem cells. 
  • Engineering of the microenvironment to accelerate vascular regeneration. 
  • Enhanced chondrogenic differentiation of embryonic stem cells by coculture with hepatic cells. 
  • Epithelial-to-mesenchymal transition activates PERK-eIF2α and sensitizes cells to endoplasmic reticulum stress. 
  • Establishment and characterization of conditionally immortalized cells from the mouse urogenital ridge. 
  • Estrogen receptor beta protects against in vivo injury in RPE cells. 
  • Evaluation of culture conditions for in vitro meniscus repair model systems using bone marrow-derived mesenchymal stem cells. 
  • Exome sequencing identifies highly recurrent MED12 somatic mutations in breast fibroadenoma. 
  • Expression Profiling of Human Schlemm's Canal Endothelial Cells From Eyes With and Without Glaucoma. 
  • Expression of laminin isoforms, receptors, and binding proteins unique to nucleus pulposus cells of immature intervertebral disc. 
  • Expression of renin-angiotensin system and extracellular matrix genes in cardiovascular cells and its regulation through AT1 receptor. 
  • Extent of Cell Confinement in Microtracks Affects Speed and Results in Differential Matrix Strains. 
  • Extracellular Matrix Degradation Products Downregulate Neoplastic Esophageal Cell Phenotype. 
  • Extracellular Matrix Remodeling Regulates Glucose Metabolism through TXNIP Destabilization. 
  • Extracellular hyaluronate pressure shaped by cellular tethers drives tissue morphogenesis. 
  • Extracellular matrix and Hippo signaling as therapeutic targets of antifibrotic compounds for uterine fibroids. 
  • Extracellular matrix disruption and pain after eccentric muscle action. 
  • Extracellular matrix in aged human ciliary body: an immunoelectron microscope study. 
  • Extracellular matrix protein betaig-h3/TGFBI promotes metastasis of colon cancer by enhancing cell extravasation. 
  • Extracellular matrix remodeling after balloon angioplasty injury in a rabbit model of restenosis. 
  • Extracellular space measurements with CMR imaging. 
  • Extracellular superoxide dismutase deficiency worsens outcome from focal cerebral ischemia in the mouse. 
  • Extracellular-matrix-based and Arg-Gly-Asp-modified photopolymerizing hydrogels for cartilage tissue engineering. 
  • Fabrication of 3D hepatic tissues by additive photopatterning of cellular hydrogels. 
  • Failure of ventral body wall closure in mouse embryos lacking a procollagen C-proteinase encoded by Bmp1, a mammalian gene related to Drosophila tolloid. 
  • Female gender, estrogen loss, and Sub-RPE deposit formation in aged mice. 
  • Fibrillar collagen and remodeling of dilated canine left ventricle. 
  • Fibrillar peptide gels in biotechnology and biomedicine. 
  • Fibrotic Changes to Schlemm's Canal Endothelial Cells in Glaucoma. 
  • Focal adhesion integrity is downregulated by the alternatively spliced domain of human tenascin. 
  • Fueling Cell Invasion through Extracellular Matrix. 
  • Functional advantages conferred by extracellular prokaryotic membrane vesicles. 
  • Future directions in idiopathic pulmonary fibrosis research. An NHLBI workshop report. 
  • Gastrulation in the sea urchin embryo requires the deposition of crosslinked collagen within the extracellular matrix. 
  • Genes of innate immunity and the biological response to inhaled ozone. 
  • Genetic Engineering of Mesenchymal Stem Cells for Differential Matrix Deposition on 3D Woven Scaffolds. 
  • Genetic association study of exfoliation syndrome identifies a protective rare variant at LOXL1 and five new susceptibility loci. 
  • Genetic elimination of α3(IV) collagen fails to rescue anti-collagen B cells. 
  • Genetic pathway analysis reveals a major role for extracellular matrix organization in inflammatory and neuropathic pain. 
  • Global phosphotyrosinylated protein profile of cell-matrix adhesion complexes of trabecular meshwork cells. 
  • Glucosamine modulates chondrocyte proliferation, matrix synthesis, and gene expression. 
  • Granular hydrogels: emergent properties of jammed hydrogel microparticles and their applications in tissue repair and regeneration. 
  • Growing up and advancing in airway smooth muscle research. 
  • Growth Differentiation Factor-15-Induced Contractile Activity and Extracellular Matrix Production in Human Trabecular Meshwork Cells. 
  • Growth factor-regulated proteases and extracellular matrix remodeling during mammalian development. 
  • Hand2 regulates extracellular matrix remodeling essential for gut-looping morphogenesis in zebrafish. 
  • Heparanase and platelet factor-4 induce smooth muscle cell proliferation and migration via bFGF release from the ECM. 
  • High attenuation areas on chest computed tomography in community-dwelling adults: the MESA study. 
  • High-resolution microrheology in the pericellular matrix of prostate cancer cells. 
  • Histoarchitecture of the fibrillary matrix of human fetal posterior tibial tendons. 
  • Histopathology of experimental preretinal neovascularization. 
  • How vinculin regulates force transmission. 
  • Human breast cancer invasion and aggression correlates with ECM stiffening and immune cell infiltration. 
  • Human cardiac fibroblasts and receptors for angiotensin II and bradykinin: a potential role for bradykinin in the modulation of cardiac extracellular matrix. 
  • Human myelomeningocele risk and ultra-rare deleterious variants in genes associated with cilium, WNT-signaling, ECM, cytoskeleton and cell migration. 
  • Hybrid photopatterned enzymatic reaction (HyPER) for in situ cell manipulation 
  • Hydrogel-based three-dimensional matrix for neural cells. 
  • Identification of Estrogen Signaling in a Prioritization Study of Intraocular Pressure-Associated Genes. 
  • Immuno-electron labelling of matrix components in congenital hereditary endothelial dystrophy. 
  • Immunochemical and biochemical characterization of a glioma-associated extracellular matrix glycoprotein. 
  • Immunofluorescence-guided atomic force microscopy to measure the micromechanical properties of the pericellular matrix of porcine articular cartilage. 
  • Immunolocalization of monoclonal antibody-defined extracellular matrix antigens in human brain tumors. 
  • In Situ Drug Delivery to Breast Cancer-Associated Extracellular Matrix. 
  • In vivo performance of dual ligand augmented endothelialized expanded polytetrafluoroethylene vascular grafts. 
  • Induction of TGF-beta1 in the trabecular meshwork under cyclic mechanical stress. 
  • Inflammatory Cytokines and Matrix Metalloproteinases in the Synovial Fluid After Intra-articular Ankle Fracture. 
  • Influence of Sterilization Technologies on Electrospun Poly(ester urea)s for Soft Tissue Repair. 
  • Influence of oxygen tension on interleukin 1-induced peroxynitrite formation and matrix turnover in articular cartilage. 
  • Influence of physical properties of biomaterials on cellular behavior. 
  • Insights from a chimpanzee adipose stromal cell population: opportunities for adult stem cells to expand primate functional genomics. 
  • Integral role for lysyl oxidase-like-1 in conventional outflow tissue function and behavior. 
  • Integrating valve-inspired design features into poly(ethylene glycol) hydrogel scaffolds for heart valve tissue engineering. 
  • Integrin-mediated interactions with extracellular matrix proteins for nucleus pulposus cells of the human intervertebral disc. 
  • Integrins and other cell adhesion molecules in endometrium and endometriosis. 
  • Interaction of apolipoprotein E with laminin increases neuronal adhesion and alters neurite morphology. 
  • Interaction of retinal glial cells with collagen matrices: implications for pathogenesis of cell-mediated vitreous traction. 
  • Interactions between dystrophin and the sarcolemma membrane. 
  • Interconnected macroporous poly(ethylene glycol) cryogels as a cell scaffold for cartilage tissue engineering. 
  • Interendothelial claudin-5 expression depends on cerebral endothelial cell-matrix adhesion by β(1)-integrins. 
  • Intradiscal injection of simvastatin results in radiologic, histologic, and genetic evidence of disc regeneration in a rat model of degenerative disc disease. 
  • Invadopodia and basement membrane invasion in vivo. 
  • Isolation and culture of human trabecular meshwork cells by extracellular matrix digestion. 
  • Laminin oligopeptide derivatized agarose gels allow three-dimensional neurite extension in vitro. 
  • Ligament-derived matrix stimulates a ligamentous phenotype in human adipose-derived stem cells. 
  • Lineage restriction of human hepatic stem cells to mature fates is made efficient by tissue-specific biomatrix scaffolds. 
  • Localization of a cryptic binding site for tenascin on fibronectin. 
  • MMP-14 and TIMP-2 overexpression protects against hydroquinone-induced oxidant injury in RPE: implications for extracellular matrix turnover. 
  • Matrix Metalloproteinases and Glaucoma Treatment. 
  • Matrix compliance permits NF-κB activation to drive therapy resistance in breast cancer. 
  • Matrix metalloproteinases and their inhibitors in human vitreous. 
  • Matrix produced by diseased cardiac fibroblasts affects early myotube formation and function. 
  • Matrix stiffness regulation of integrin-mediated mechanotransduction during osteogenic differentiation of human mesenchymal stem cells. 
  • Maximizing phenotype constraint and extracellular matrix production in primary human chondrocytes using arginine-glycine-aspartate concentration gradient hydrogels. 
  • Measurement of endothelial permeability to 125I-low density lipoproteins in rabbit arteries by use of en face preparations. 
  • Mechanical Signaling and Extracellular Matrix in Uterine Fibroids. 
  • Mechanical homeostasis is altered in uterine leiomyoma. 
  • Mechanical regulation of nuclear structure and function. 
  • Mechanical signaling in reproductive tissues: mechanisms and importance. 
  • Mechanically induced integrin ligation mediates intracellular calcium signaling with single pulsating cavitation bubbles. 
  • Mechanism of Fibronectin Binding to Human Trabecular Meshwork Exosomes and Its Modulation by Dexamethasone. 
  • Mechanisms of disease progression in NASH: new paradigms. 
  • Mechanistic basis of Rho GTPase-induced extracellular matrix synthesis in trabecular meshwork cells. 
  • Medulloblastoma cell-substrate interaction in vitro. 
  • Meniscus-Derived Matrix Bioscaffolds: Effects of Concentration and Cross-Linking on Meniscus Cellular Responses and Tissue Repair. 
  • Meniscus-Derived Matrix Scaffolds Promote the Integrative Repair of Meniscal Defects. 
  • Metabolic glycan labeling and chemoselective functionalization of native biomaterials. 
  • Method for decellularizing skeletal muscle without detergents or proteolytic enzymes. 
  • MicroRNA-182 drives metastasis of primary sarcomas by targeting multiple genes. 
  • Microglia-mediated degradation of perineuronal nets promotes pain. 
  • Micromechanical mapping of early osteoarthritic changes in the pericellular matrix of human articular cartilage. 
  • Microscale diffusion properties of the cartilage pericellular matrix measured using 3D scanning microphotolysis. 
  • Mineralized gelatin methacrylate-based matrices induce osteogenic differentiation of human induced pluripotent stem cells. 
  • Modeling the Early Steps of Ovarian Cancer Dissemination in an Organotypic Culture of the Human Peritoneal Cavity. 
  • Modeling the tumor extracellular matrix: Tissue engineering tools repurposed towards new frontiers in cancer biology. 
  • Modification of integrin-mediated cell attachment to substrata by serine proteinases in the presence and absence of divalent cations. 
  • Modulation of gene expression in neonatal rat cardiomyocytes by surface modification of polylactide-co-glycolide substrates. 
  • Molecular therapies for vascular diseases. 
  • Molecular-Scale Tools for Studying Mechanotransduction. 
  • Morphogenesis: Shaping Tissues through Extracellular Force Gradients. 
  • Multi-component extracellular matrices based on peptide self-assembly. 
  • Multifactorial optimization of endothelial cell growth using modular synthetic extracellular matrices. 
  • Multilayered electrospun scaffolds for tendon tissue engineering. 
  • Mutations near amino end of alpha1(I) collagen cause combined osteogenesis imperfecta/Ehlers-Danlos syndrome by interference with N-propeptide processing. 
  • Myocardial remodelling and matrix metalloproteinases in heart failure: turmoil within the interstitium. 
  • NIEHS/EPA Workshops. Cellular migration. 
  • New Insight of Common Regulatory Pathways in Human Trabecular Meshwork Cells in Response to Dexamethasone and Prednisolone Using an Integrated Quantitative Proteomics: SWATH and MRM-HR Mass Spectrometry. 
  • Nitric oxide-generating hydrogels inhibit neointima formation. 
  • Out of Eden: stem cells and their niches. 
  • Overexpression of cell surface cytokeratin 8 in multidrug-resistant MCF-7/MX cells enhances cell adhesion to the extracellular matrix. 
  • Overexpression of extracellular superoxide dismutase reduces acute radiation induced lung toxicity. 
  • Overexpression of lysyl oxidase to increase matrix crosslinking and improve tissue strength in dermal wound healing. 
  • Overload-induced skeletal muscle extracellular matrix remodelling and myofibre growth in mice lacking IL-6. 
  • Pacing-induced heart failure: a model to study the mechanism of disease progression and novel therapy in heart failure. 
  • Parathyroid hormone 1-34 enhances extracellular matrix deposition and organization during flexor tendon repair. 
  • Passive ventricular mechanics in tight-skin mice. 
  • Pentosan polysulfate decreases prostate smooth muscle proliferation and extracellular matrix turnover. 
  • Peripheral blood levels of matrix metalloproteinases in patients referred for percutaneous balloon mitral valve commissurotomy. 
  • Peritoneal and subperitoneal stroma may facilitate regional spread of ovarian cancer. 
  • Pharmacodynamics of basic fibroblast growth factor: route of administration determines myocardial and systemic distribution. 
  • Phenotypic analysis of four human medulloblastoma cell lines and transplantable xenografts. 
  • Pigment epithelium-derived factor regulates early pancreatic fibrotic responses and suppresses the profibrotic cytokine thrombospondin-1. 
  • Plexin D1 determines body fat distribution by regulating the type V collagen microenvironment in visceral adipose tissue. 
  • Polar axis fixation in Fucus zygotes: components of the cytoskeleton and extracellular matrix. 
  • Porphyrin-Based SOD Mimic MnTnBu OE -2-PyP5+ Inhibits Mechanisms of Aortic Valve Remodeling in Human and Murine Models of Aortic Valve Sclerosis. 
  • Prestress in the extracellular matrix sensitizes latent TGF-β1 for activation. 
  • Primary human chondrocyte extracellular matrix formation and phenotype maintenance using RGD-derivatized PEGDM hydrogels possessing a continuous Young's modulus gradient. 
  • Profiling and targeting connective tissue remodeling in autoimmunity - A novel paradigm for diagnosing and treating chronic diseases. 
  • Protease production by cultured microglia: substrate gel analysis and immobilized matrix degradation. 
  • Proteoglycans of uterine fibroids and keloid scars: similarity in their proteoglycan composition. 
  • Proteomics characterization of cell membrane blebs in human retinal pigment epithelium cells. 
  • Quantifying cellular traction forces in three dimensions. 
  • RAP2 mediates mechanoresponses of the Hippo pathway. 
  • RB-mediated tumor suppression of a lung cancer cell line is abrogated by an extract enriched in extracellular matrix. 
  • Regional localization of a glioma-associated antigen defined by monoclonal antibody 81C6 in vivo: kinetics and implications for diagnosis and therapy. 
  • Regulated exocytosis and sequential construction of the extracellular matrix surrounding the sea urchin zygote. 
  • Regulation of angiotensin II receptors and extracellular matrix turnover in human retinal pigment epithelium: role of angiotensin II. 
  • Regulation of connective tissue growth factor expression in the aqueous humor outflow pathway. 
  • Regulation of plasminogen activation by components of the extracellular matrix. 
  • Regulation of plasticity and fibrogenic activity of trabecular meshwork cells by Rho GTPase signaling. 
  • Regulation of vascular permeability factor/vascular endothelial growth factor (VPF/VEGF-A) expression in podocytes. 
  • Reichert's membrane as a model for studying the biosynthesis and assembly of basement membrane components. 
  • Relations of matrix remodeling biomarkers to blood pressure progression and incidence of hypertension in the community. 
  • Relevance for neurobiology and neurooncology of antigens of malignant gliomas as defined by monoclonal antibodies. 
  • Repetitive nonlethal oxidant injury to retinal pigment epithelium decreased extracellular matrix turnover in vitro and induced sub-RPE deposits in vivo. 
  • Response of zonal chondrocytes to extracellular matrix-hydrogels. 
  • Retention of the native chondrocyte pericellular matrix results in significantly improved matrix production. 
  • Revisiting the mystery of fibronectin multimers: the fibronectin matrix is composed of fibronectin dimers cross-linked by non-covalent bonds. 
  • RhoA regulates initiation of invagination, but not convergent extension, during sea urchin gastrulation. 
  • Role of pericellular matrix in development of a mechanically functional neocartilage. 
  • SGK1 signaling promotes glucose metabolism and survival in extracellular matrix detached cells. 
  • SMAD3 deficiency promotes vessel wall remodeling, collagen fiber reorganization and leukocyte infiltration in an inflammatory abdominal aortic aneurysm mouse model. 
  • SPARC Promotes Cell Invasion In Vivo by Decreasing Type IV Collagen Levels in the Basement Membrane. 
  • Scaffold-free, Human Mesenchymal Stem Cell-Based Tissue Engineered Blood Vessels. 
  • Scaffold-mediated lentiviral transduction for functional tissue engineering of cartilage. 
  • Secretion of extracellular matrix-degrading proteinases is increased in epithelial ovarian carcinoma. 
  • Severe airway epithelial injury, aberrant repair and bronchiolitis obliterans develops after diacetyl instillation in rats. 
  • Single molecular force spectroscopy of modular proteins in the nervous system. 
  • Smooth muscle cell growth in photopolymerized hydrogels with cell adhesive and proteolytically degradable domains: synthetic ECM analogs for tissue engineering. 
  • Smooth muscle cell rigidity and extracellular matrix organization influence endothelial cell spreading and adhesion formation in coculture. 
  • Sonic hedgehog ligand partners with caveolin-1 for intracellular transport. 
  • Spatial control of neuronal cell attachment and differentiation on covalently patterned laminin oligopeptide substrates. 
  • Spatial mapping of the biomechanical properties of the pericellular matrix of articular cartilage measured in situ via atomic force microscopy. 
  • Stemming Lung Disease? 
  • Storage and mobilization of extracellular matrix proteins during sea urchin development. 
  • Stromal gene signatures in large-B-cell lymphomas. 
  • Structural basement membrane components and corresponding integrins in Schlemm's canal endothelia. 
  • Structure of the cumulus matrix and zona pellucida in the golden hamster: a new view of sperm interaction with oocyte-associated extracellular matrices. 
  • Substrate Stiffness Controls Osteoblastic and Chondrocytic Differentiation of Mesenchymal Stem Cells without Exogenous Stimuli. 
  • Synergistic role of HSP90α and HSP90β to promote myofibroblast persistence in lung fibrosis. 
  • Synthetic ECM: Bioactive Synthetic Hydrogels for 3D Tissue Engineering. 
  • TAK1 regulates SOX9 expression in chondrocytes and is essential for postnatal development of the growth plate and articular cartilages. 
  • TRPV4-mediated calcium signaling in mesenchymal stem cells regulates aligned collagen matrix formation and vinculin tension. 
  • Targeted activation of c-Jun N-terminal kinase in vivo induces restrictive cardiomyopathy and conduction defects. 
  • Temporal spatial expression and function of non-muscle myosin II isoforms IIA and IIB in scar remodeling. 
  • Tenascin expression in prostatic hyperplasia, intraepithelial neoplasia, and carcinoma. 
  • Tenascin is induced at implantation sites in the mouse uterus and interferes with epithelial cell adhesion. 
  • Tenascin-C inhibits extracellular matrix-dependent gene expression in mammary epithelial cells. Localization of active regions using recombinant tenascin fragments. 
  • Tenascin-C knockout mouse has no detectable tenascin-C protein. 
  • Tenascin-C, tenascin-R and tenascin-X: a family of talented proteins in search of functions. 
  • Tenascin/hexabrachion in human skin: biochemical identification and localization by light and electron microscopy. 
  • Tenascin: an extracellular matrix protein prominent in specialized embryonic tissues and tumors. 
  • Teriparatide as a chondroregenerative therapy for injury-induced osteoarthritis. 
  • Testis formation in the fetal mouse: dynamic and complex de novo tubulogenesis. 
  • Tethered-TGF-beta increases extracellular matrix production of vascular smooth muscle cells. 
  • The Diacetyl-Exposed Human Airway Epithelial Secretome: New Insights into Flavoring-Induced Airways Disease. 
  • The ErbB2ΔEx16 splice variant is a major oncogenic driver in breast cancer that promotes a pro-metastatic tumor microenvironment. 
  • The RGD motif in fibronectin is essential for development but dispensable for fibril assembly. 
  • The actin membrane skeleton in Drosophila development. 
  • The cell and molecular biology of glaucoma: mechanisms in the conventional outflow pathway. 
  • The control of foxN2/3 expression in sea urchin embryos and its function in the skeletogenic gene regulatory network. 
  • The effect of enzymatically degradable poly (ethylene glycol) hydrogels on smooth muscle cell phenotype 
  • The effects of acellular dermal matrix in expander-implant breast reconstruction after total skin-sparing mastectomy: results of a prospective practice improvement study. 
  • The effects of ascorbic acid on cartilage metabolism in guinea pig articular cartilage explants. 
  • The effects of exposure of articular cartilage to air. A histochemical and ultrastructural investigation. 
  • The extracellular matrix protein mindin is a pattern-recognition molecule for microbial pathogens. 
  • The human myoepithelial cell displays a multifaceted anti-angiogenic phenotype. 
  • The inhibition by interleukin 1 of MSC chondrogenesis and the development of biomechanical properties in biomimetic 3D woven PCL scaffolds. 
  • The matrix protein Fibulin-5 is at the interface of tissue stiffness and inflammation in fibrosis. 
  • The micro-mechanics of single molecules studied with atomic force microscopy. 
  • The perplexing complexity of cardiac arrhythmias: beyond electrical remodeling. 
  • The role of Osteopontin in tumor metastasis. 
  • The role of extracellular matrix composition in structure and function of bioengineered skeletal muscle. 
  • The role of extracellular matrix elasticity and composition in regulating the nucleus pulposus cell phenotype in the intervertebral disc: a narrative review. 
  • The use of optical clearing and multiphoton microscopy for investigation of three-dimensional tissue-engineered constructs 
  • Therapeutic efficacy of antiglioma mesenchymal extracellular matrix 131I-radiolabeled murine monoclonal antibody in a human glioma xenograft model. 
  • Three-Dimensional Printing of Nano Hydroxyapatite/Poly(ester urea) Composite Scaffolds with Enhanced Bioactivity. 
  • Three-dimensional traction force microscopy: a new tool for quantifying cell-matrix interactions. 
  • Tissue Engineering Approaches to Uncover Therapeutic Targets for Endothelial Dysfunction in Pathological Microenvironments. 
  • Tissue engineered bone mimetics to study bone disorders ex vivo: Role of bioinspired materials. 
  • Tissue linkage through adjoining basement membranes: The long and the short term of it. 
  • Tissue mechanics modulate microRNA-dependent PTEN expression to regulate malignant progression. 
  • Tissue transglutaminase expression in human breast cancer. 
  • Tissue-specific expression and regulation of the alternatively-spliced forms of lysyl hydroxylase 2 (LH2) in human kidney cells and skin fibroblasts. 
  • Tissue-specific, temporal changes in cell adhesion to echinonectin in the sea urchin embryo. 
  • Trafficking mechanisms of extracellular matrix macromolecules: insights from vertebrate development and human diseases. 
  • Transfection in the third dimension 
  • Transforming growth factor beta3 regulates the versican variants in the extracellular matrix-rich uterine leiomyomas. 
  • Transition to invasive breast cancer is associated with progressive changes in the structure and composition of tumor stroma. 
  • Trimers of the fibronectin cell adhesion domain localize to actin filament bundles and undergo rearward translocation. 
  • Tunable PEG Hydrogels for Discerning Differential Tumor Cell Response to Biomechanical Cues. 
  • Twist1 in Infiltrating Macrophages Attenuates Kidney Fibrosis via Matrix Metallopeptidase 13-Mediated Matrix Degradation. 
  • Type V Collagen in Scar Tissue Regulates the Size of Scar after Heart Injury. 
  • Type VI Collagen Regulates Pericellular Matrix Properties, Chondrocyte Swelling, and Mechanotransduction in Mouse Articular Cartilage. 
  • Up-regulated expression of extracellular matrix remodeling genes in phagocytically challenged trabecular meshwork cells. 
  • Utilizing cell–matrix interactions to modulate gene transfer to stem cells inside hyaluronic acid hydrogels 
  • VEGF internalization is not required for VEGFR-2 phosphorylation in bioengineered surfaces with covalently linked VEGF 
  • Vascular remodeling: mechanisms and implications. 
  • Vesicoureteral reflux and the extracellular matrix connection. 
  • Viable bone marrow stromal cells are required for the in vitro survival of B-cell precursor acute lymphoblastic leukemic cells. 
  • Wisteria floribunda lectin is associated with specific cell types in the ventral cochlear nucleus of the gerbil, Meriones unguiculatus. 
  • X-ray diffraction analysis of isolated skin lipids: reconstitution of intercellular lipid domains. 
  • Zonal changes in the three-dimensional morphology of the chondron under compression: The relationship among cellular, pericellular, and extracellular deformation in articular cartilage 
  • alphaSU2, an epithelial integrin that binds laminin in the sea urchin embryo. 
  • p38 MAP kinase mediates inflammatory cytokine induction in cardiomyocytes and extracellular matrix remodeling in heart. 
  • β-arrestin deficiency protects against pulmonary fibrosis in mice and prevents fibroblast invasion of extracellular matrix. 
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  Keywords of People

  • Erickson, Harold Paul, James B. Duke Distinguished Professor Emeritus, Cell Biology
  • Hogan, Brigid L. M., Research Professor of Cell Biology, Cell Biology
  • McDonnell, Donald Patrick, Glaxo-Wellcome Distinguished Professor of Molecular Cancer Biology, in the School of Medicine, Cell Biology
  • Sherwood, David R., Jerry G. and Patricia Crawford Hubbard Professor, Biology
  • Stinnett, Sandra Sue, Associate Professor of Biostatistics & Bioinformatics, Biostatistics & Bioinformatics