Extracellular Space

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  Subject Areas on Research

  • A Fluorescent Hsp90 Probe Demonstrates the Unique Association between Extracellular Hsp90 and Malignancy in Vivo. 
  • A local hyperthermia treatment which enhances antibody uptake in a glioma xenograft model does not affect tumour interstitial fluid pressure. 
  • A mathematical model for histamine synthesis, release, and control in varicosities 
  • A tridomain model for potassium clearance in optic nerve of Necturus. 
  • Acid mucopolysaccharides in the outflow apparatus. 
  • Actions of thrombin in the interstitium. 
  • Adaptation of cat motoneurons to sustained and intermittent extracellular activation. 
  • Airway smooth muscle dysfunction in Pompe (Gaa-/- ) mice. 
  • Alkaline Phosphatase, Soluble Extracellular Adenine Nucleotides, and Adenosine Production after Infant Cardiopulmonary Bypass. 
  • Altered intracellular and extracellular signaling leads to impaired T-cell functions in ADA-SCID patients. 
  • Altered ultrastructural morphology of self-aggregated low density lipoproteins: coalescence of lipid domains forming droplets and vesicles. 
  • An image-based RNAi screen identifies SH3BP1 as a key effector of Semaphorin 3E-PlexinD1 signaling. 
  • An upper limit for the electrogenic Na-K pump contribution to maximum diastolic potential in feline cardiac Purkinje fibers in steady state. 
  • Angiogenesis, microvascular architecture, microhemodynamics, and interstitial fluid pressure during early growth of human adenocarcinoma LS174T in SCID mice. 
  • Antibody-induced growth inhibition is mediated through immunochemically and functionally distinct epitopes on the extracellular domain of the c-erbB-2 (HER-2/neu) gene product p185. 
  • Apolipoprotein E is present in hippocampal neurons without neurofibrillary tangles in Alzheimer's disease and in age-matched controls. 
  • Apolipoprotein E protects against oxidative stress in mixed neuronal-glial cell cultures by reducing glutamate toxicity. 
  • Associations between Cardiac Magnetic Resonance T1 Mapping Parameters and Ventricular Arrhythmia in Patients with Chagas Disease. 
  • Asymmetry of neuronal activity during extracellular microelectrode recording from left and right human temporal lobe neocortex during rhyming and line-matching. 
  • Attenuation of cerebral vasospasm after subarachnoid hemorrhage in mice overexpressing extracellular superoxide dismutase. 
  • Available space and extracellular transport of macromolecules: effects of pore size and connectedness. 
  • BMP antagonism protects Nodal signaling in the gastrula to promote the tissue interactions underlying mammalian forebrain and craniofacial patterning. 
  • Biomechanical strain as a trigger for pore formation in Schlemm's canal endothelial cells. 
  • Blocking the interaction between apolipoprotein E and Aβ reduces intraneuronal accumulation of Aβ and inhibits synaptic degeneration. 
  • Bursts and the efficacy of selective serotonin reuptake inhibitors. 
  • Calcium-sensing receptor regulates stomatal closure through hydrogen peroxide and nitric oxide in response to extracellular calcium in Arabidopsis. 
  • Capsaicin and nicotine both activate a subset of rat trigeminal ganglion neurons. 
  • Cardiac extracellular potentials. Analysis of complex wave forms about the Purkinje networks in dogs. 
  • Characterization of the hyperpolarization-activated chloride current in dissociated rat sympathetic neurons. 
  • Chemokine production by G protein-coupled receptor activation in a human mast cell line: roles of extracellular signal-regulated kinase and NFAT. 
  • Chloride dependence of hyperpolarization-activated chloride channel gates. 
  • Collision of excitation waves in the dog Purkinje system. Extracellular identification. 
  • Combining 'caged-dopamine' photolysis with fast-scan cyclic voltammetry to assess dopamine clearance and release autoinhibition in vitro. 
  • Come forth CD1d: Hsp110 in the regulation of intestinal epithelial CD1d expression. 
  • Comparative studies of erythrophagocytosis in the rabbit and human vitreous. 
  • Comprehensive population-averaged arterial input function for dynamic contrast-enhanced vmagnetic resonance imaging of head and neck cancer. 
  • Concerted use of immunologic and ultrastructural analyses in diagnostic medicine: immunoelectron microscopy and correlative microscopy. 
  • Concurrent autoreceptor-mediated control of dopamine release and uptake during neurotransmission: an in vivo voltammetric study. 
  • Contrast enhanced liver MRI in patients with primary sclerosing cholangitis: inverse appearance of focal confluent fibrosis on delayed phase MR images with hepatocyte specific versus extracellular gadolinium based contrast agents. 
  • Depression of sustained evoked potentials and glial depolarization in the spinal cord by barbiturates and by diphenylhydantoin. 
  • Differential localization of placental extracellular superoxide dismutase as pregnancy progresses. 
  • Distinct patterns of fat metabolism in skeletal muscle of normal-weight, overweight, and obese humans. 
  • Distribution and significance of hyaluronidase-sensitive materials in the trabecular wall of Schlemm's canal. 
  • Dopamine efflux during withdrawal from continuous or intermittent cocaine. 
  • Dynamics of segmental extracellular volumes during changes in body position by bioimpedance analysis. 
  • Dysregulation of ectonucleotidase-mediated extracellular adenosine during postmenopausal bone loss. 
  • Early extracellular and cellular lipid deposits in aorta of cholesterol-fed rabbits. 
  • Effect of nonuniform interstitial space properties on impulse propagation: a discrete multidomain model. 
  • Effects of electroporation on transmembrane potential induced by defibrillation shocks. 
  • Effects of myocardial water exchange on T1 enhancement during bolus administration of MR contrast agents. 
  • Effects of stimulation frequency on potassium activity and cell volume in cardiac tissue. 
  • Electromobility of plasmid DNA in tumor tissues during electric field-mediated gene delivery. 
  • Electrophysiological interaction through the interstitial space between adjacent unmyelinated parallel fibers. 
  • Endogenous production of extracellular adenosine by trabecular meshwork cells: potential role in outflow regulation. 
  • Enhanced tonic GABA current in normotopic and hilar ectopic dentate granule cells after pilocarpine-induced status epilepticus. 
  • Estimation of cardiac bidomain parameters from extracellular measurement: two dimensional study. 
  • Expression of extracellular glutathione peroxidase in human and mouse gastrointestinal tract. 
  • Extracellular (volume conductor) effect on adjoining cardiac muscle electrophysiology. 
  • Extracellular Ca2+ mobilization in potential-dependent contraction of trachealis of maturing swine. 
  • Extracellular discontinuities in cardiac muscle: evidence for capillary effects on the action potential foot. 
  • Extracellular field required for excitation in three-dimensional anisotropic canine myocardium. 
  • Extracellular hyaluronate pressure shaped by cellular tethers drives tissue morphogenesis. 
  • Extracellular ions, hypoxic irreversible loss of function and delayed postischemic neuron degeneration studied in vitro. 
  • Extracellular pH modulates block of both sodium and calcium channels by nicardipine. 
  • Extracellular potassium influences DNA and protein syntheses and glial fibrillary acidic protein expression in cultured glial cells. 
  • Extracellular superoxide dismutase in the airways of transgenic mice reduces inflammation and attenuates lung toxicity following hyperoxia. 
  • Extracellular superoxide dismutase overexpression improves behavioral outcome from closed head injury in the mouse. 
  • Extracellular superoxide dismutase overexpression protects against aging-induced cognitive impairment in mice. 
  • Extracellular superoxide dismutase protects lung development in hyperoxia-exposed newborn mice. 
  • Extracellular superoxide dismutase, nitric oxide, and central nervous system O2 toxicity. 
  • Extracellular superoxide dismutase. 
  • Fine structure of a radiation-induced osteogenic sarcoma. 
  • Fluorescence ratio imaging of interstitial pH in solid tumours: effect of glucose on spatial and temporal gradients. 
  • Furosemide and mannitol suppression of epileptic activity in the human brain. 
  • Genesis of the monophasic action potential: role of interstitial resistance and boundary gradients. 
  • High molecular weight extracellular proteins synthesized by endoderm cells derived from mouse teratocarcinoma cells and normal extraembryonic membranes. 
  • Homeostatic mechanisms in dopamine synthesis and release: a mathematical model. 
  • Hydrogen peroxide production by alveolar type II cells, alveolar macrophages, and endothelial cells. 
  • In vivo assessment of free radical activity during shock wave lithotripsy using a microdialysis system: the renoprotective action of allopurinol. 
  • Incorporation of biotinylated SP-A into rat lung surfactant layer, type II cells, and clara cells. 
  • Increased interstitial loading reduces the effect of microstructural variations in cardiac tissue. 
  • Increased microvascular permeability contributes to preferential accumulation of Stealth liposomes in tumor tissue. 
  • Induction of tissue-type plasminogen activator and 72-kDa type-IV collagenase by ionizing radiation in rat astrocytes. 
  • Inhibition of nitric oxide synthase increases extracellular cerebral glutamate concentration after global ischemia. 
  • Inputs from the ipsilateral and contralateral vestibular apparatus to behaviorally characterized abducens neurons in rhesus monkeys. 
  • Interactions between extracellular stimuli and excitation waves in an atrial reentrant loop. 
  • Intercellular Protein Transfer from Thymocytes to Thymic Epithelial Cells. 
  • Intercellular growth factor signaling and the development of mouse tracheal submucosal glands. 
  • Interleukin-1 beta decreases acetylcholine measured by microdialysis in the hippocampus of freely moving rats. 
  • Interleukin-1beta elevates cyclooxygenase-2 protein level and enzyme activity via increasing its mRNA stability in human endometrial stromal cells: an effect mediated by extracellularly regulated kinases 1 and 2. 
  • Interstitial hydraulic conductivity in a fibrosarcoma. 
  • Ischemic injury and extracellular amino acid accumulation in hippocampal area CA1 are not dependent upon an intact septo-hippocampal pathway. 
  • Leukemia inhibitory factor, oncostatin M, IL-6, and stem cell factor mRNA expression in human thymus increases with age and is associated with thymic atrophy. 
  • Macrophage-mediated fungistasis in vitro: requirements for intracellular and extracellular cytotoxicity. 
  • Magnificent seven: roles of G protein-coupled receptors in extracellular sensing in fungi. 
  • Manipulation of intra- and extracellular pH in spontaneous canine tumours by use of hyperglycaemia. 
  • Mast cell-derived particles deliver peripheral signals to remote lymph nodes. 
  • Mechanism of natriuresis during intrarenal infusion of prostaglandins. 
  • Membrane currents underlying bursting pacemaker activity and spike frequency adaptation in invertebrates. 
  • MicroRNAs in placental health and disease. 
  • Microdialysis assessment of shock wave lithotripsy-induced renal injury. 
  • Microparticles as a source of extracellular DNA. 
  • Microvascular permeability and interstitial penetration of sterically stabilized (stealth) liposomes in a human tumor xenograft. 
  • Modeling deep brain stimulation: point source approximation versus realistic representation of the electrode. 
  • Modelling the periodicity of cardiac muscle. 
  • Models of dopaminergic and serotonergic signaling. 
  • Modest increase in extracellular potassium unmasks effect of recurrent mossy fiber growth. 
  • Modifications of the cardiac double-layer source arising from interstitial potentials. 
  • Molecular manipulations of extracellular superoxide dismutase: functional importance for learning. 
  • Molecular overexpression of extracellular superoxide dismutase increases the dependency of learning and memory performance on motivational state. 
  • Morphologic aspects of the protection by endotoxin against acute and chronic oxygen-induced lung injury in adult rats. 
  • Neurohumoral mechanisms in heart failure: role in pathogenesis, therapy, and drug tolerance. 
  • Nitric oxide synthase inhibition and extracellular glutamate concentration after cerebral ischemia/reperfusion. 
  • Novel mitochondrial derived Nuclear Excisosome degrades nuclei during differentiation of prosimian Galago (bush baby) monkey lenses. 
  • Nucleic acid scavenging polymers inhibit extracellular DNA-mediated innate immune activation without inhibiting anti-viral responses. 
  • Nucleic acid-binding polymers as anti-inflammatory agents. 
  • Optical imaging reveals elevated intracellular chloride in hippocampal pyramidal neurons after oxidative stress. 
  • Optimal tuning of bacterial sensing potential. 
  • Overexpression of extracellular superoxide dismutase reduces acute radiation induced lung toxicity. 
  • Oxidative and nonoxidative macronutrient disposal in lean and obese men after mixed meals. 
  • Oxidative stress and inflammation contribute to lung toxicity after a common breast cancer chemotherapy regimen. 
  • PRCD is essential for high-fidelity photoreceptor disc formation. 
  • Physiologic effects of extracellular superoxide dismutase transgene overexpression on myocardial function after ischemia and reperfusion injury. 
  • Postsynaptic Mechanisms Render Syn I/II/III Mice Highly Responsive to Psychostimulants. 
  • Potentiation of calcium levels by extracellular arachidonic acid in nuclei isolated from macrophages stimulated with receptor-recognized forms of alpha(2)-macroglobulin. 
  • Prenatal hypoxia decreases lung extracellular superoxide dismutase expression and activity. 
  • Pressure effects on the distribution of extracellular materials in the rhesus monkey outflow apparatus. 
  • Proconvulsant and anticonvulsant properties of ethanol: studies of electrographic seizures in vitro. 
  • Protection of perfused lung from oxidant injury by inhibitors of anion exchange. 
  • Proton-gated ion channels in mouse bone marrow stromal cells. 
  • Pus: the Rodney Dangerfield of immunology. 
  • Quantitative analysis of the spatiotemporal dynamics of a synthetic predator-prey ecosystem. 
  • Quantitative ultrastructural analysis of perifibrous lipid and its association with elastin in nonatherosclerotic human aorta. 
  • Recirculatory pharmacokinetic models of markers of blood, extracellular fluid and total body water administered concomitantly. 
  • Reconstructing the engram: simultaneous, multisite, many single neuron recordings. 
  • Reduced extracellular dopamine and increased responsiveness to novelty: neurochemical and behavioral sequelae of intermittent hypoxia. 
  • Regulation of cation channels in liver cells by intracellular calcium and protein kinase C. 
  • Regulation of extracellular calcium entry in endothelial cells: role of intracellular calcium pool. 
  • Regulation of interleukin-8 expression by cellular pH in human pancreatic adenocarcinoma cells. 
  • Renal function in the AT1A receptor knockout mouse during normal and volume-expanded conditions. 
  • Restriction of tumor growth in mice by sodium-deficient diet. 
  • Role for the Abi/wave protein complex in T cell receptor-mediated proliferation and cytoskeletal remodeling. 
  • Role of extracellular disulfide-bonded cysteines in the ligand binding function of the beta 2-adrenergic receptor. 
  • Sampling rates required for digital recording of intracellular and extracellular cardiac potentials. 
  • Secretion of extracellular superoxide dismutase in neonatal lungs. 
  • Sensitivity of temporal excitation properties to the neuronal element activated by extracellular stimulation. 
  • Simultaneous administration of glucose and hyperoxic gas achieves greater improvement in tumor oxygenation than hyperoxic gas alone. 
  • Single residues in the outer pore of TRPV1 and TRPV3 have temperature-dependent conformations. 
  • Strain-dependent effects of environmental signals on the production of extracellular phospholipase by Cryptococcus neoformans. 
  • Study of unipolar electrogram morphology in a computer model of atrial fibrillation. 
  • Succinylcholine-induced hyperkalemia: effects of succinylcholine on resting potentials and electrolyte distributions in normal and denervated muscle. 
  • Survival of allografted pancreatic islets in the subretinal space in rats. 
  • Synaptic clustering of AMPA receptors by the extracellular immediate-early gene product Narp. 
  • Synthesis and localization of two sulphated glycoproteins associated with basement membranes and the extracellular matrix. 
  • Temperature dependence of potassium clearance in the central nervous system. 
  • The Alarmin Properties of DNA and DNA-associated Nuclear Proteins. 
  • The brain interstitial system: Anatomy, modeling, in vivo measurement, and applications. 
  • The contribution of local blood flow to the rapid clearance of potassium from the cortical extracellular space. 
  • The effect of aldosterone on water and electrolyte composition of incubated rat diaphragms. 
  • The effect of interstitial air on the in vitro thrombogenicity of ePTFE vascular grafts. 
  • The engine driving the ship: metabolic steering of cell proliferation and death. 
  • The extracellular release of DNA and HMGB1 from Jurkat T cells during in vitro necrotic cell death. 
  • The impact of adjacent isotropic fluids on electrograms from anisotropic cardiac muscle. A modeling study. 
  • The inflammatory response to cardiopulmonary bypass. 
  • The influence of removing extracellular Ca2+ in the desensitization responses to capsaicin, zingerone and olvanil in rat trigeminal ganglion neurons. 
  • The relationship between apoptosis and high-mobility group protein 1 release from murine macrophages stimulated with lipopolysaccharide or polyinosinic-polycytidylic acid. 
  • The responses of atrial natriuretic factor concentrations to acute volume changes in conscious rats. 
  • The role of lipoproteins in atherogenesis. 
  • The von Hippel-Lindau tumor suppressor gene inhibits hepatocyte growth factor/scatter factor-induced invasion and branching morphogenesis in renal carcinoma cells. 
  • Transvascular drug delivery in solid tumors. 
  • Two different mechanisms underlie reversible, intrinsic optical signals in rat hippocampal slices. 
  • Ultrastructural analysis of damage to nuclear fiber cell membranes in advanced age-related cataracts from India. 
  • Ultrastructural discrimination of lipid droplets and vesicles in atherosclerosis: value of osmium-thiocarbohydrazide-osmium and tannic acid-paraphenylenediamine techniques. 
  • Ultrastructure of hypertensive rat aorta. Increased basement membrane-like material. 
  • Urea as a recovery marker for quantitative assessment of tumor interstitial solutes with microdialysis. 
  • Validation of changes in extracellular volume measured during hemodialysis using a segmental bioimpedance technique. 
  • [Extracellular Ca2+ signaling: first messenger in animals and plants]. 
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  Keywords of People

  • Berchuck, Andrew, James M. Ingram Distinguished Professor of Gynecologic Oncology, Obstetrics and Gynecology, Gynecologic Oncology
  • Charles, Hal Cecil, Adjunct Associate Professor in the Department of Radiology, Radiology
  • Craciunescu, Oana, Professor of Radiation Oncology, Radiation Oncology
  • Henriquez, Craig S., Professor of Biomedical Engineering, Biomedical Engineering
  • Hogan, Brigid L. M., Research Professor of Cell Biology, Cell Biology
  • Krangel, Michael S., George Barth Geller Distinguished Professor of Immunology, Integrative Immunobiology