Extremities

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  Subject Areas on Research

  • A Logical Model of Homology for Comparative Biology. 
  • A multi-institution experience comparing the clinical and physiologic differences between upper extremity and lower extremity melphalan-based isolated limb infusion. 
  • A multi-institutional experience of isolated limb infusion: defining response and toxicity in the US. 
  • A multicenter phase I dose escalation trial to evaluate safety and tolerability of intra-arterial temozolomide for patients with advanced extremity melanoma using normothermic isolated limb infusion. 
  • A multicenter prospective evaluation of the clinical utility of F-18 FDG-PET/CT in patients with AJCC stage IIIB or IIIC extremity melanoma. 
  • A new model predicting locomotor cost from limb length via force production. 
  • A phase 1 study of systemic ADH-1 in combination with melphalan via isolated limb infusion in patients with locally advanced in-transit malignant melanoma. 
  • A phase I multi-institutional study of systemic sorafenib in conjunction with regional melphalan for in-transit melanoma of the extremity. 
  • ACR Appropriateness Criteria® Chronic Extremity Joint Pain-Suspected Inflammatory Arthritis, Crystalline Arthritis, or Erosive Osteoarthritis: 2022 Update. 
  • ADAMTS metalloproteases generate active versican fragments that regulate interdigital web regression. 
  • Accessories to Limb Regeneration. 
  • Adjunctive β2-agonist treatment reduces glycogen independently of receptor-mediated acid α-glucosidase uptake in the limb muscles of mice with Pompe disease. 
  • Adjuvant chemotherapy for osteosarcoma of the extremity. Long-term results of two consecutive prospective protocol studies. 
  • Adjuvant radiation therapy increases disease-free survival in stage IB Merkel cell carcinoma. 
  • Advanced Modeling to Predict Pneumonia in Combat Trauma Patients. 
  • Age-related disparities in the use of radiotherapy for treatment of localized soft tissue sarcoma. 
  • Ambulatory discharge after long-acting peripheral nerve blockade: 2382 blocks with ropivacaine. 
  • Amniotic band syndrome in fetal lambs. I: Fetoscopic release and morphometric outcome. 
  • Amputation versus limb salvage. 
  • Analysis of "old" proteins unmasks dynamic gradient of cartilage turnover in human limbs. 
  • Angiography and the pediatric trauma patient: a 10-year review. 
  • Assessment of multimodality therapy use for extremity sarcoma in the United States. 
  • Autologous bone marrow mononuclear cell therapy is safe and promotes amputation-free survival in patients with critical limb ischemia. 
  • Biomechanics: deadly strike mechanism of a mantis shrimp. 
  • Body dimensions of Japanese and American gymnasts. 
  • Bone morphogenetic proteins in development. 
  • CYP2C19 status and risk of major adverse cardiovascular events in peripheral artery disease: Insights from the EUCLID Trial. 
  • Cadherin-11 expressed in association with mesenchymal morphogenesis in the head, somite, and limb bud of early mouse embryos. 
  • Can laboratory model systems instruct human limb regeneration? 
  • Childhood rhabdomyosarcoma. Analysis of coordinated therapy and results. 
  • Colocalization of BMP 7 and BMP 2 RNAs suggests that these factors cooperatively mediate tissue interactions during murine development. 
  • Combining levodopa and virtual reality-based therapy for rehabilitation of the upper limb after acute stroke: pilot study Part II. 
  • Comment on "Grasping primate origins". 
  • Comparative spring mechanics in mantis shrimp. 
  • Comparison of 3D X-ray tomography with computed tomography in patients with distal extremity fractures. 
  • Comparison of real and idealized cetacean flippers. 
  • Comparison of the expression of three highly related genes, Fgf8, Fgf17 and Fgf18, in the mouse embryo. 
  • Composite tissue allotransplantation: classification of clinical acute skin rejection. 
  • Computed tomography of benign angiomatous lesions of the extremities. 
  • Continuous peripheral nerve block for ambulatory surgery. 
  • Cutaneous involvement by T-cell prolymphocytic leukemia presenting as livedoid vasculopathy. 
  • De novo mutations in NALCN cause a syndrome characterized by congenital contractures of the limbs and face, hypotonia, and developmental delay. 
  • Defining a textbook surgical outcome for patients undergoing surgical resection of intermediate and high-grade soft tissue sarcomas of the extremities. 
  • Designing a Rational Follow-Up Schedule for Patients with Extremity Soft Tissue Sarcoma. 
  • Disability fingerprints: patterns of disability in spinal cord injury and multiple sclerosis differ. 
  • Don't hedge your bets: hedgehog signaling as a central mediator of endochondral bone development and cartilage diseases. 
  • Drosophila nonmuscle myosin II has multiple essential roles in imaginal disc and egg chamber morphogenesis. 
  • Early experience with computed tomographic angiography in microsurgical reconstruction. 
  • Effect of exercise and ischemia on tissue oximetry and cytochrome in normal subjects, patients with chronic limb pain, and patients with mitochondrial mitopathies. 
  • Effective limb length and the scaling of locomotor cost in terrestrial animals. 
  • Effects of U-37883A, a vascular selective KATP+ channel antagonist, in the pulmonary and hindlimb circulation. 
  • Effects of head and body cooling on hemodynamics during immersed prone exercise at 1 ATA. 
  • Efficacy of hyperthermic isolated limb perfusion for extremity-confined recurrent melanoma. 
  • Emergent Endovascular Treatment of Penetrating Trauma: Solid Organ and Extremity. 
  • Eruptive pseudoangiomatosis: a unique childhood exanthem? 
  • Evolution of novel abdominal appendages in a sepsid fly from histoblasts, not imaginal discs. 
  • Examination of national lymph node evaluation practices for adult extremity soft tissue sarcoma. 
  • Extravasation of nonionic radiologic contrast media: efficacy of conservative treatment. 
  • Extreme impact and cavitation forces of a biological hammer: strike forces of the peacock mantis shrimp Odontodactylus scyllarus. 
  • Extremity War Injury Symposium XV: Sports and Readiness Symposium Summary. 
  • Fgf-dependent depletion of microRNA-133 promotes appendage regeneration in zebrafish. 
  • Fgfs control homeostatic regeneration in adult zebrafish fins. 
  • Genetic interactions between Shox2 and Hox genes during the regional growth and development of the mouse limb. 
  • Granular cell tumors of the extremities. 
  • Hybrid Metachronal Rowing Augments Swimming Speed and Acceleration via Increased Stroke Amplitude. 
  • Immunotherapy following regional chemotherapy treatment of advanced extremity melanoma. 
  • Incidence, Characteristics, and Outcomes of Myocardial Infarction in Patients With Peripheral Artery Disease: Insights From the EUCLID Trial. 
  • Increased beta-catenin protein and somatic APC mutations in sporadic aggressive fibromatoses (desmoid tumors). 
  • Increased local failure for patients with intermediate-risk rhabdomyosarcoma on ARST0531: A report from the Children's Oncology Group. 
  • Induction of lef1 during zebrafish fin regeneration. 
  • Inhibition of poly(ADP-ribose) polymerase enhances the effect of chemotherapy in an animal model of regional therapy for the treatment of advanced extremity malignant melanoma. 
  • Involvement of Bone Morphogenetic Protein-4 (BMP-4) and Vgr-1 in morphogenesis and neurogenesis in the mouse. 
  • Ischemic limb necrosis in septic shock: What is the role of high-dose vasopressor therapy? 
  • Isolated Limb Infusion as a Limb Salvage Strategy for Locally Advanced Extremity Sarcoma. 
  • Isolated limb infusion for in-transit malignant melanoma of the extremity: a well-tolerated but less effective alternative to hyperthermic isolated limb perfusion. 
  • Keeping at arm's length during regeneration. 
  • Lack of correlation between the central anti-nociceptive and peripheral anti-inflammatory effects of selective COX-2 inhibitor parecoxib. 
  • Leiomyosarcoma of the somatic soft tissues. 
  • Limb salvage versus amputation in patients with osteosarcoma of the extremities: an update in the modern era using the National Cancer Database. 
  • Limited regional cerebellar dysfunction induces focal dystonia in mice. 
  • Lithium dilution cardiac output measurement: a clinical assessment of central venous and peripheral venous indicator injection. 
  • Long-Term Oncologic Outcomes After Isolated Limb Infusion for Locoregionally Metastatic Melanoma: An International Multicenter Analysis. 
  • Long-Term Outcomes and Associations With Major Adverse Limb Events After Peripheral Artery Revascularization. 
  • MDCT angiography of pediatric vascular diseases of the abdomen, pelvis, and extremities. 
  • Maintenance of blastemal proliferation by functionally diverse epidermis in regenerating zebrafish fins. 
  • Management of extremity soft tissue sarcomas with limb-sparing surgery and postoperative irradiation: do total dose, overall treatment time, and the surgery-radiotherapy interval impact on local control? 
  • Management of recurrent melanoma of the extremity. 
  • Marked variability of melphalan plasma drug levels during regional hyperthermic isolated limb perfusion. 
  • Mirror movements complicate interpretation of cerebral activation changes during recovery from subcortical infarction. 
  • Modularity and rates of evolutionary change in a power-amplified prey capture system. 
  • Mps1 defines a proximal blastemal proliferative compartment essential for zebrafish fin regeneration. 
  • Mucosal erosions and bullae in a child. Pemphigus vulgaris in a child with tinea capitis. 
  • Multi-level analysis of elastic morphology: the mantis shrimp’s spring 
  • Myoid differentiation and prognosis in adult pleomorphic sarcomas of the extremity: an analysis of 92 cases. 
  • NCCN Guidelines Insights: Soft Tissue Sarcoma, Version 1.2021. 
  • Nanostructures and Monolayers of Spheres Reduce Surface Reflections in Hyperiid Amphipods. 
  • New regulators of vertebrate appendage regeneration. 
  • Novel approach to the treatment of distal malperfusion secondary to ascending aortic dissection. 
  • Novel intrathecal and subcutaneous catheter delivery systems in the mouse. 
  • Nursing care of patients undergoing isolated limb procedures for recurrent melanoma of the extremity. 
  • Oncologic Outcomes After Isolated Limb Infusion for Advanced Melanoma: An International Comparison of the Procedure and Outcomes Between the United States and Australia. 
  • Optimizing melphalan pharmacokinetics in regional melanoma therapy: does correcting for ideal body weight alter regional response or toxicity? 
  • Optimizing regional infusion treatment strategies for melanoma of the extremities. 
  • Organogenesis and pattern formation in the mouse: RNA distribution patterns suggest a role for bone morphogenetic protein-2A (BMP-2A). 
  • Outcomes of the Keystone Island Perforator Flap: A Systematic Review. 
  • Partial co-option of the appendage patterning pathway in the development of abdominal appendages in the sepsid fly Themira biloba. 
  • Pediatric cutaneous angiosarcomas: a clinicopathologic study of 10 cases. 
  • Periodic limb movement variability in older DIMS patients across consecutive nights of home monitoring. 
  • Peripheral nerve block techniques for ambulatory surgery. 
  • Peripheral nerve blockade with long-acting local anesthetics: a survey of the Society for Ambulatory Anesthesia. 
  • Plasma cytokine analysis in patients with advanced extremity melanoma undergoing isolated limb infusion. 
  • Positional cloning of a temperature-sensitive mutant emmental reveals a role for sly1 during cell proliferation in zebrafish fin regeneration. 
  • Practical radiation oncology for extremity sarcomas. 
  • Predicting the energy cost of terrestrial locomotion: a test of the LiMb model in humans and quadrupeds. 
  • Predictors of outcome after hyperthermic isolated limb perfusion: role of tumor response. 
  • Prognostic factors for fibromatoses: a correlation of proliferation index, estrogen receptor, p53, retinoblastoma, and src gene products and clinical features with outcome. 
  • Prospective multicenter phase II trial of systemic ADH-1 in combination with melphalan via isolated limb infusion in patients with advanced extremity melanoma. 
  • Purpura fulminans. 
  • Quality of life after isolated limb infusion for in-transit melanoma of the extremity. 
  • Rac1 activation controls nuclear localization of beta-catenin during canonical Wnt signaling. 
  • Race is an independent predictor of survival in patients with soft tissue sarcoma of the extremities. 
  • Randomized multicenter trial of hyperthermic isolated limb perfusion with melphalan alone compared with melphalan plus tumor necrosis factor: American College of Surgeons Oncology Group Trial Z0020. 
  • Reference data on in vitro anatomy and indentation response of tissue layers of musculoskeletal extremities. 
  • Reference data on thickness and mechanics of tissue layers and anthropometry of musculoskeletal extremities. 
  • Regeneration of amputated zebrafish fin rays from de novo osteoblasts. 
  • Regenerative scaffold electrodes for peripheral nerve interfacing. 
  • Regional vascular responses to prolonged lower body negative pressure in normal subjects. 
  • Relating ranging ecology, limb length, and locomotor economy in terrestrial animals. 
  • Resection of residual disease after isolated limb infusion (ILI) is equivalent to a complete response after ILI-alone in advanced extremity melanoma. 
  • Retinoic acid receptor alpha function in vertebrate limb skeletogenesis: a modulator of chondrogenesis. 
  • Rocky Mountain spotted fever complicated by gangrene: report of six cases and review. 
  • Roles for Fgf signaling during zebrafish fin regeneration. 
  • Scaling and mechanics of carnivoran footpads reveal the principles of footpad design. 
  • Seasonal variation in body mass and locomotor kinetics of the fat-tailed dwarf lemur (Cheirogaleus medius). 
  • Sensory and response interference by ipsilesional stimuli in tactile extinction. 
  • Single fiber electromyography in chronic progressive external ophthalmoplegia. 
  • Soft Tissue Sarcoma, Version 2.2022, NCCN Clinical Practice Guidelines in Oncology. 
  • Statin therapy and long-term adverse limb outcomes in patients with peripheral artery disease: insights from the REACH registry. 
  • Surgical treatment and prognosis in patients with high-grade soft tissue malignant fibrous histiocytoma of the extremities. 
  • Survival differences between patients with scalp or neck melanoma and those with melanoma of other sites in the Surveillance, Epidemiology, and End Results (SEER) program. 
  • Systemic doxorubicin and intraarterial cisplatin preoperative chemotherapy plus postoperative adjuvant chemotherapy in patients with osteosarcoma. 
  • Technical note: out-of-plane angular correction based on a trigonometric function for use in two-dimensional kinematic studies. 
  • Temozolomide is a novel regional infusion agent for the treatment of advanced extremity melanoma. 
  • The Banff 2007 working classification of skin-containing composite tissue allograft pathology. 
  • The Extremity War Injury Symposium: Emerging Combat and Readiness Research. 
  • The concept of fillet flaps: classification, indications, and analysis of their clinical value. 
  • The inhibition of differentiation caused by TGFbeta in fetal myoblasts is dependent upon selective expression of PKCtheta: a possible molecular basis for myoblast diversification during limb histogenesis. 
  • The origin and evolution of animal appendages. 
  • The return of tourniquets. Original research evaluates the effectiveness of prehospital tourniquets for civilian penetrating extremity injuries. 
  • The role of hyperthermia in regional alkylating agent chemotherapy. 
  • The roles of growth regulation and appendage patterning genes in the morphogenesis of treehopper pronota. 
  • The segment polarity gene porcupine encodes a putative multitransmembrane protein involved in Wingless processing. 
  • Three-dimensional, automated, real-time video system for tracking limb motion in brain-machine interface studies. 
  • Thrombolytic Salvage of Threatened Frostbitten Extremities and Digits: A Systematic Review. 
  • Tissue expansion of free and pedicled flaps after transfer: possibilities and indications. 
  • Two urokinase dose regimens in native arterial and graft occlusions: initial results of a prospective, randomized clinical trial. 
  • UBC-Nepal expedition: upper and lower limb conduit artery shear stress and flow-mediated dilation on ascent to 5,050 m in lowlanders and Sherpa. 
  • Use of the tourniquet during surgery in patients with sickle cell hemoglobinopathies. 
  • Utilizing Precision Medicine to Estimate Timing for Surgical Closure of Traumatic Extremity Wounds. 
  • Vascularized tissue transfer for closure of irradiated wounds after soft tissue sarcoma resection. 
  • Venography of the extremities and pelvis. 
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  Keywords of People

  • Nielsen, Karen Cristina, Associate Professor of Anesthesiology, Anesthesiology, Ambulatory
  • Olson, Steven Arthur, Goldner Jones Distinguished Professor of Orthopaedic Surgery, Orthopaedic Surgery