Eye

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  Subject Areas on Research

  • A 6-year-old boy with facial swelling and monocular blindness. 
  • A biomimetic Schlemm's canal inner wall: A model to study outflow physiology, glaucoma pathology and high-throughput drug screening. 
  • A chiton uses aragonite lenses to form images. 
  • A comparison of the rate of refractive growth in pediatric aphakic and pseudophakic eyes. 
  • A complicated case of ciliary body melanoma and glaucoma. 
  • A highly distributed Bragg stack with unique geometry provides effective camouflage for Loliginid squid eyes. 
  • A novel eye in 'eyeless' shrimp from hydrothermal vents of the Mid-Atlantic Ridge. 
  • A study of cataract in murine congenital toxoplasmosis. 
  • A tripartite interaction among alleles of Notch, Delta, and Enhancer of split during imaginal development of Drosophila melanogaster. 
  • A unique advantage for giant eyes in giant squid. 
  • AIDS-related cytomegalovirus retinitis: lessons from the laboratory. 
  • Accessibility to and Quality of Human Eye Tissue for Research: A Cross-Sectional Survey of ARVO Members. 
  • Active cytomegalovirus particles in the eyes of an AIDS patient being treated with 9-[2-hydroxy-1-(hydroxymethyl) ethoxymethyl] guanine (Ganciclovir). 
  • Altered mechanobiology of Schlemm's canal endothelial cells in glaucoma. 
  • An Update of Eye Shape and Myopia. 
  • Anesthesia for intraocular surgery. 
  • Angiotensin II-induced hypertension regulates AT1 receptor subtypes and extracellular matrix turnover in mouse retinal pigment epithelium. 
  • Are myopic eyes less likely to have diabetic retinopathy? 
  • Association of age, stature, and education with ocular dimensions in an older white population. 
  • Association of intraocular pressure and myopia in children. 
  • Attentional and eye tracking deficits correlate with negative symptoms in schizophrenia. 
  • BE-FAST (Balance, Eyes, Face, Arm, Speech, Time): Reducing the Proportion of Strokes Missed Using the FAST Mnemonic. 
  • BMP4 is essential for lens induction in the mouse embryo. 
  • Body mass index and its effects on retinal vessel diameter in 6-year-old children. 
  • Bone morphogenetic proteins in development. 
  • Botulinum toxin for blepharospasm: single-fiber EMG studies. 
  • Cellular senescence in the glaucomatous outflow pathway. 
  • Central regulation of photosensitive membrane turnover in the lateral eye of Limulus. I. Octopamine primes the retina for daily transient rhabdom shedding. 
  • Central retinal vein occlusion in patients treated with long-term warfarin sodium (Coumadin) for anticoagulation. 
  • Characterization of intraocular immunopathology following intracameral inoculation with alloantigen. 
  • Chronic dry eye disease is principally mediated by effector memory Th17 cells. 
  • Clearance of antitransferrin receptor immunotoxin from the rabbit eye. 
  • Clinical characteristics and mortality rates for suprachoroidal hemorrhage: seven-year experience at a tertiary eye center. 
  • Collagens in ocular tissues. 
  • Combined central retinal vein and artery occlusion associated with an isolated superior ophthalmic vein thrombosis. 
  • Communicative eye contact signals a commitment to cooperate for young children. 
  • Comparison of dynamic contour tonometry and goldmann applanation tonometry in African American subjects. 
  • Computational visual ecology in the pelagic realm. 
  • Congenital neuro-ophthalmic toxoplasmosis in the mouse. 
  • Congenital ocular defects associated with an abnormality of the human chromosome 1: trisomy 1q32-qter. 
  • Contactless optical coherence tomography of the eyes of freestanding individuals with a robotic scanner. 
  • Contralateral decreased visual acuity and extraocular muscle palsies following retrobulbar anesthesia. 
  • Core-shell nanospheres behind the blue eyes of the bay scallop Argopecten irradians . 
  • Current concepts in the management of central retinal vein occlusion. 
  • Cycling in the Cell Fate Landscape. 
  • De Novo Pathogenic Variants in N-cadherin Cause a Syndromic Neurodevelopmental Disorder with Corpus Collosum, Axon, Cardiac, Ocular, and Genital Defects. 
  • Dedication of Special Issue on Purinergic Regulation in the Eye to Mortimer M. Civan. 
  • Determinants of angle closure in older Singaporeans. 
  • Development, Validation, and Innovation in Ophthalmic Laser-Based Imaging: Report From a US Food and Drug Administration-Cosponsored Forum. 
  • Dietary factors, myopia, and axial dimensions in children. 
  • Differential gene expression in mouse sclera during ocular development. 
  • Discovery and functional annotation of SIX6 variants in primary open-angle glaucoma. 
  • Distribution and determinants of ocular biometric parameters in an Asian population: the Singapore Malay eye study. 
  • Distribution of axial length and ocular biometry measured using partial coherence laser interferometry (IOL Master) in an older white population. 
  • Do routine eye exams improve vision? 
  • Doing without learning: stimulation of the frontal eye fields and floccular complex does not instruct motor learning in smooth pursuit eye movements. 
  • Drosophila betaHeavy-spectrin is essential for development and contributes to specific cell fates in the eye. 
  • Education, socioeconomic status, and ocular dimensions in Chinese adults: the Tanjong Pagar Survey. 
  • Effect of Axial Eye Length on Retinal Vessel Parameters in 6 to 12-Year-Old Malay Girls. 
  • Effect of axial length on retinal vascular network geometry. 
  • Effects of molting on the visual acuity of the blue crab, Callinectes sapidus. 
  • Effects of ocular carteolol and timolol on plasma high-density lipoprotein cholesterol level. 
  • Effects of organophosphates on the visual system of rats. 
  • Emerging therapeutics for ocular surface disease. 
  • Evaluation of a delivery system providing long-term release of cyclosporine. 
  • Evidence that a locus for familial high myopia maps to chromosome 18p. 
  • Evidence that eye-facing photophores serve as a reference for counterillumination in an order of deep-sea fishes. 
  • Examining the Effects of Chromatic Aberration, Object Distance, and Eye Shape on Image-Formation in the Mirror-Based Eyes of the Bay Scallop Argopecten irradians. 
  • Experimental ocular toxocariasis: a mouse model. 
  • Eye-derived cytokines and the immunosuppressive intraocular microenvironment: a review. 
  • Fibrotic Changes to Schlemm's Canal Endothelial Cells in Glaucoma. 
  • Formation and maintenance of synaptic connections in autonomic ganglia. 
  • Functional reconstitution of purified metabotropic glutamate receptor expressed in the fly eye. 
  • GPR158 in the Visual System: Homeostatic Role in Regulation of Intraocular Pressure. 
  • Genetic association study of exfoliation syndrome identifies a protective rare variant at LOXL1 and five new susceptibility loci. 
  • Genome-wide meta-analysis of myopia and hyperopia provides evidence for replication of 11 loci. 
  • Geometry of neonatal neurones and the regulation of synapse elimination. 
  • Growth inhibition of human Tenon's capsule fibroblasts and rabbit dermal fibroblasts with non-carcinogenic N-alkylated anthracyclines. 
  • HSV-1 retinitis and delayed hypersensitivity in DBA/2 and C57BL/6 mice. 
  • Haploinsufficiency of the transcription factors FOXC1 and FOXC2 results in aberrant ocular development. 
  • Hematolymphoid malignancies with intraocular intravascular involvement: report of 2 cases. 
  • Histopathologic features of trabeculectomy surgery. 
  • How does hypertension affect your eyes? 
  • Human retinal hemodynamics following administration of 5-isosorbide mononitrate. 
  • Hypermetropia, axial length, and hypertension: the Tanjong Pagar survey. 
  • Identification of Tgf beta1i4 as a downstream target of Foxc1. 
  • Immunofluorescent studies of the eye in Waldenström's macroglobulinemia. 
  • Immunoregulatory mechanisms of the eye. 
  • Improving eye care in residential aged care facilities using the Residential Ocular Care (ROC) model: study protocol for a multicentered, prospective, customized, and cluster randomized controlled trial in Australia. 
  • In-utero epigenetic factors are associated with early-onset myopia in young children. 
  • Increasing the Availability and Quality of Donor Eyes for Research. 
  • Induction and Characterization of the Allergic Eye Disease Mouse Model. 
  • International Chronic Ocular Graft-vs-Host-Disease (GVHD) Consensus Group: proposed diagnostic criteria for chronic GVHD (Part I). 
  • Joint Effect of Early Microvascular Damage in the Eye &Kidney on Risk of Cardiovascular Events. 
  • LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development. 
  • Late traumatic wound rupture following successful partial penetrating keratoplasty. 
  • Lateral and axial measurement differences between spectral-domain optical coherence tomography systems. 
  • Learning from healthy and stable eyes: A new approach for detection of glaucomatous progression. 
  • Level of tear cytokines in population-level participants and correlation with clinical features. 
  • Localized steady-state oxygen measurements from the preretinal space of the rabbit eye using 19F NMR. 
  • Loss of Drosophila melanogaster p21-activated kinase 3 suppresses defects in synapse structure and function caused by spastin mutations. 
  • Loss of the perforin cytotoxic pathway predisposes mice to experimental cytomegalovirus retinitis. 
  • MOSFET dosimetry for radiation dose assessment of bismuth shielding of the eye in children. 
  • MPS VI associated ocular phenotypes in an MPS VI murine model and the therapeutic effects of odiparcil treatment. 
  • Microwave refraction in the eye. 
  • Miliary blastomycosis with metastatic spread to posterior uvea of both eyes. 
  • Molecular genetics of human myopia: an update. 
  • Molecular phylogenetic evidence for the independent evolutionary origin of an arthropod compound eye. 
  • Morphology of the fibrinogen exudate during evolution of a mycobacterial-induced murine eye granuloma. 
  • Mouse small eye results from mutations in a paired-like homeobox-containing gene. 
  • Multiple dosing of prostaglandin F2 alpha or epinephrine on cynomolgus monkey eyes. III. Histopathology. 
  • Murine cytomegalovirus retinitis during MAIDS: Susceptibility correlates with elevated intraocular levels of interleukin-4 mRNA. 
  • Murine cytomegalovirus retinitis during retrovirus-induced immunodeficiency (MAIDS) in mice: interleukin-2 immunotherapy correlates with increased intraocular levels of perforin mRNA. 
  • Myopia in young adults is inversely related to an objective marker of ocular sun exposure: the Western Australian Raine cohort study. 
  • Myopia, axial length, and OCT characteristics of the macula in Singaporean children. 
  • Neutrophil L-Plastin Controls Ocular Paucibacteriality and Susceptibility to Keratitis. 
  • New insights into mononuclear phagocyte biology from the visual system. 
  • Nonclinical Safety and Toxicokinetics of MnTnBuOE-2-PyP5+ (BMX-001). 
  • Novel association of smaller anterior chamber width with angle closure in Singaporeans. 
  • Ocular albumin fluorophotometric quantitation of endotoxin-induced vascular permeability. 
  • Ocular blood flow in unilateral carotid stenosis and hypotension. 
  • Ocular component growth curves among Singaporean children with different refractive error status. 
  • Ocular manifestations of multiple myeloma, Waldenström's macroglobulinemia and benign monoclonal gammopathy. 
  • Ocular manifestations of preeclampsia. 
  • Ocular mucosal CD11b+ and CD103+ mouse dendritic cells under normal conditions and in allergic immune responses. 
  • Ocular neoplastic disease. 
  • Ocular pathology of Fabry's disease in a hemizygous male following renal transplantation. 
  • Ocular penetration of 5-fluorocytosine. 
  • Ocular signs of brain stimulation in the human. 
  • Ocular sonography in pre-eclampsia: a simple technique to detect raised intracranial pressure? 
  • Ophthalmic phenotypes and the representativeness of twin data for the general population. 
  • Optimizing gene transfer to conventional outflow cells in living mouse eyes. 
  • Osteological evidence for the evolution of activity pattern and visual acuity in primates. 
  • Patient-preferred sites of restylane injection in periocular and facial soft-tissue augmentation. 
  • Pediatric cataract, myopic astigmatism, familial exudative vitreoretinopathy and primary open-angle glaucoma co-segregating in a family. 
  • Penetration of new azole compounds into the eye and efficacy in experimental Candida endophthalmitis. 
  • Periocular fillers and related anatomy. 
  • Phenotypic stability of Pro347Leu rhodopsin transgenic pigs as indicated by photoreceptor cell degeneration. 
  • Physical activity, television viewing time, and retinal vascular caliber. 
  • Powerful ideas driven by simple tools: lessons from experimental embryology. 
  • Preparation and study of human eyes obtained postmortem with the Miyake posterior photographic technique. 
  • Prevalence, Risk Factors, and Impact of Undiagnosed Visually Significant Cataract: The Singapore Epidemiology of Eye Diseases Study. 
  • Prox 1, a prospero-related homeobox gene expressed during mouse development. 
  • Psychosocial Outcomes in Adult Survivors of Retinoblastoma. 
  • Quantifiable Biomarkers of Normal Aging in the Japanese Medaka Fish (Oryzias latipes) 
  • Quantitatively comparing weekly changes in retinal vascular characteristics of eyes eventually treated versus not treated for retinopathy of prematurity. 
  • Ras promotes cell survival by antagonizing both JNK and Hid signals in the Drosophila eye. 
  • Recent advances in the applications of metabolomics in eye research. 
  • Refractive error, axial dimensions, and primary open-angle glaucoma: the Singapore Malay Eye Study. 
  • Rejuvenation of the Upper Face and Periocular Region: Combining Neuromodulator, Facial Filler, Laser, Light, and Energy-Based Therapies for Optimal Results. 
  • Relationship of axial length and retinal vascular caliber in children. 
  • Repeatability and Reproducibility of Quantification of Superficial Peri-papillary Capillaries by four Different Optical Coherence Tomography Angiography Devices. 
  • Rethinking primate origins 
  • Retinal microvascular abnormalities and blood pressure in older people: the Cardiovascular Health Study. 
  • Review of international criteria and mixture rules for health hazard classification. 
  • Rho GDP dissociation inhibitor-mediated disruption of Rho GTPase activity impairs lens fiber cell migration, elongation and survival. 
  • Rho GTPase/Rho kinase inhibition as a novel target for the treatment of glaucoma. 
  • SYK inhibitor entospletinib prevents ocular and skin GVHD in mice. 
  • Scintigraphic evaluation of the ocular disposition of 18F-imirestat in rabbits. 
  • Silicone oil for progressive anterior ocular neovascularization after failed diabetic vitrectomy. 
  • Sites of neuronal excitation by epiretinal electrical stimulation. 
  • Small eye (Sey): a mouse model for the genetic analysis of craniofacial abnormalities. 
  • Small eyes (Sey): a homozygous lethal mutation on chromosome 2 which affects the differentiation of both lens and nasal placodes in the mouse. 
  • Spectral sensitivity of the concave mirror eyes of scallops: potential influences of habitat, self-screening and longitudinal chromatic aberration. 
  • Stent/coil treatment of very large and giant unruptured ophthalmic and cavernous aneurysms. 
  • Study of a US cohort supports the role of ZNF644 and high-grade myopia susceptibility. 
  • Subacute ethanol consumption reverses p-xylene-induced decreases in axonal transport. 
  • Susceptibility to murine cytomegalovirus retinitis during progression of MAIDS: correlation with intraocular levels of tumor necrosis factor-alpha and interferon-gamma. 
  • Systemic, Ocular and Genetic Risk Factors for Age-related Macular Degeneration and Polypoidal Choroidal Vasculopathy in Singaporeans. 
  • T helper subsets in allergic eye disease. 
  • Targeted Delivery of Cell Softening Micelles to Schlemm's Canal Endothelial Cells for Treatment of Glaucoma. 
  • Targeting VE-PTP activates TIE2 and stabilizes the ocular vasculature. 
  • Telemedicine for ophthalmic consultation services: use of a portable device and layering information for graders. 
  • The AAV vector toolkit: poised at the clinical crossroads. 
  • The Drosophila Cadherin Fat regulates tissue size and planar cell polarity through different domains. 
  • The Flk1-myr::mCherry mouse as a useful reporter to characterize multiple aspects of ocular blood vessel development and disease. 
  • The Matrix Metalloproteinase 9 Point-of-Care Test in Dry Eye. 
  • The clinical utility of dynamic contour tonometry and ocular pulse amplitude. 
  • The deubiquitinating enzyme DUBAI stabilizes DIAP1 to suppress Drosophila apoptosis. 
  • The effect of parental history of myopia on eye size of pre-school children: a pilot study. 
  • The effects of post-ganglionic axotomy on selective synaptic connexions in the superior cervical ganglion of the guinea-pig. 
  • The efficacy of a multimedia educational campaign to increase the use of eye care services. 
  • The eye: A window to the soul of the immune system. 
  • The forkhead/winged helix gene Mf1 is disrupted in the pleiotropic mouse mutation congenital hydrocephalus. 
  • The forkhead/winged-helix gene, Mf1, is necessary for the normal development of the cornea and formation of the anterior chamber in the mouse eye. 
  • The giant eyes of giant squid are indeed unexpectedly large, but not if used for spotting sperm whales. 
  • The normal anatomy of the pig tailed macaque (Macaca nemestrina) outflow apparatus with particular reference to the presence of smooth muscle. 
  • The relationship between ocular dimensions and refraction with adult stature: the Tanjong Pagar Survey. 
  • The role of protein kinase C in modulation of aqueous humor outflow facility. 
  • The superfast extraocular myosin (MYH13) is localized to the innervation zone in both the global and orbital layers of rabbit extraocular muscle. 
  • Theoretical strategy for choosing piggyback intraocular lens powers in young children. 
  • Three-dimensional magnetic resonance microscopy of the developing chick embryo. 
  • Toxic actions of dinoseb in medaka (Oryzias latipes) embryos as determined by in vivo 31P NMR, HPLC-UV and 1H NMR metabolomics. 
  • Transgenic indicator mice for studying activated retinoic acid receptors during development. 
  • Transplantation of feline islets of Langerhans in the subretinal space of cat eyes. 
  • Two eyes for two purposes: in situ evidence for asymmetric vision in the cockeyed squids Histioteuthis heteropsis and Stigmatoteuthis dofleini. 
  • Ultrasonic examination of the silicone-filled eye: theoretical and practical considerations. 
  • Ultrastructure of the eye in fetal type II glycogenosis (Pompe's disease). 
  • Unexpected autopsy findings arising from postmortem ocular examination. 
  • Unraveling a multifactorial late-onset disease: from genetic susceptibility to disease mechanisms for age-related macular degeneration. 
  • Use of pulmonary arteriovenous extracorporeal membrane oxygenation in conjunction with the total artificial heart. 
  • Vascular risk factors in glaucoma: a review. 
  • Visual acuity in ray-finned fishes correlates with eye size and habitat. 
  • Visualization of conventional outflow tissue responses to netarsudil in living mouse eyes. 
  • Vorapaxar and diplopia: Possible off-target PAR-receptor mismodulation. 
  • Whole genome expression profiling of normal human fetal and adult ocular tissues. 
  • [A study of suitable age for intraocular lens implantation in children according to ocular anatomy and development]. 
  • rAAV-compatible MiniPromoters for restricted expression in the brain and eye. 
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  Keywords of People

  • Bowes Rickman, Catherine, George and Geneva Boguslavsky Distinguished Professor of Eye Research, Cell Biology
  • Busuioc, Corina Adela, Medical Instructor in the Department of Ophthalmology, Ophthalmology, Corneal Diseases
  • Farsiu, Sina, Professor in the Department of Biomedical Engineering, Electrical and Computer Engineering
  • Fekrat, Sharon, Professor of Ophthalmology, Ophthalmology, Vitreoretinal Diseases & Surgery
  • Liu, Yutao, Adjunct Assistant Professor in the Department of Medicine, Medicine, Medical Genetics
  • Mruthyunjaya, Prithvi, Adjunct Associate Professor in the Department of Ophthalmology, Ophthalmology, Vitreoretinal Diseases & Surgery
  • Stinnett, Sandra Sue, Associate Professor of Biostatistics & Bioinformatics, Biostatistics & Bioinformatics
  • Toth, Cynthia Ann, Joseph A.C. Wadsworth Distinguished Professor of Ophthalmology, Biomedical Engineering
  • Woodward, Julie Ann, Professor of Ophthalmology, Dermatology