-
Subject Areas on Research
-
A binding site for Pax proteins regulates expression of the gene for the neural cell adhesion molecule in the embryonic spinal cord.
-
A comprehensive mutation analysis of RP2 and RPGR in a North American cohort of families with X-linked retinitis pigmentosa.
-
A proteomic analysis of human cilia: identification of novel components.
-
A role for myocilin in receptor-mediated endocytosis.
-
A simplified method for the isolation of highly purified bovine retinal S antigen.
-
A tissue-engineered human trabecular meshwork hydrogel for advanced glaucoma disease modeling.
-
APOE Isoforms Control Pathogenic Subretinal Inflammation in Age-Related Macular Degeneration.
-
Abnormal cone ERGs in a family with congenital nystagmus and photophobia harboring a p.X423Lfs mutation in the PAX6 gene.
-
Absence of synaptic regulation by phosducin in retinal slices.
-
Alterations in human trabecular meshwork cell homeostasis by selenium.
-
An unusual X-linked retinoschisis phenotype and biochemical characterization of the W112C RS1 mutation.
-
Analysis of the molecular interaction of the farnesyl moiety of transducin through the use of a photoreactive farnesyl analogue.
-
Angiotensin II-induced hypertension regulates AT1 receptor subtypes and extracellular matrix turnover in mouse retinal pigment epithelium.
-
Ankyrin-B is required for coordinated expression of beta-2-spectrin, the Na/K-ATPase and the Na/Ca exchanger in the inner segment of rod photoreceptors.
-
Aquaporin-1 expression and conventional aqueous outflow in human eyes.
-
Association of common SIX6 polymorphisms with peripapillary retinal nerve fiber layer thickness: the Singapore Chinese Eye Study.
-
Astrocytes follow ganglion cell axons to establish an angiogenic template during retinal development.
-
Autoimmune dacryoadenitis of NOD/LtJ mice and its subsequent effects on tear protein composition.
-
Autophagic dysregulation in glaucomatous trabecular meshwork cells.
-
Autosomal recessive best vitelliform macular dystrophy: report of a family and management of early-onset neovascular complications.
-
Avian Binocularity and Adaptation to Nocturnal Environments: Genomic Insights from a Highly Derived Visual Phenotype.
-
BMP4 is essential for lens induction in the mouse embryo.
-
Beta-adrenergic receptor kinase-2 and beta-arrestin-2 as mediators of odorant-induced desensitization.
-
Beta-adrenergic receptor kinase: identification of a novel protein kinase that phosphorylates the agonist-occupied form of the receptor.
-
Beta-arrestin2, a novel member of the arrestin/beta-arrestin gene family.
-
Biochemical and biomechanical characteristics of dystrophin-deficient mdx3cv mouse lens.
-
CMPK1 and RBP3 are associated with corneal curvature in Asian populations.
-
CYP1B1, MYOC, and LTBP2 mutations in primary congenital glaucoma patients in the United States.
-
Ca(2+)-dependent interaction of recoverin with rhodopsin kinase.
-
Ca++-switch induction of RPE differentiation.
-
Changes in the expression of transcription factors ATF-2 and Fra-2 after axotomy and during regeneration in rat retinal ganglion cells.
-
Characterization of corneal proteoglycans under vitamin A deficiency.
-
Characterization of free-floating spheres from human trabecular meshwork (HTM) cell culture in vitro.
-
Characterizing differences between MSCs and TM cells: Toward autologous stem cell therapies for the glaucomatous trabecular meshwork.
-
Choroidal Thickness and En Face Optical Coherence Tomography Imaging in Autoimmune Retinopathy.
-
Chromosome Xq23 is associated with lower atherogenic lipid concentrations and favorable cardiometabolic indices.
-
Clinical and immunohistochemical evidence for an X linked retinitis pigmentosa syndrome with recurrent infections and hearing loss in association with an RPGR mutation.
-
Cloning of zebrafish vsx1: expression of a paired-like homeobox gene during CNS development.
-
Coiled-coil targeting of myocilin to intracellular membranes.
-
Comment on "Identification of Novel G Protein-Coupled Receptor 143 Ligands as Pharmacologic Tools for Investigating X-Linked Ocular Albinism".
-
Comment on 'A PAX6 gene polymorphism is associated with genetic predisposition to extreme myopia'.
-
Correlation of Color Fundus Photograph Grading with Risks of Early Age-related Macular Degeneration by using Automated OCT-derived Drusen Measurements.
-
Cyclic phosphorylation-dephosphorylation of rhodopsin in retina by protein kinase FA (the activator of ATP.Mg-dependent protein phosphatase).
-
Cytoprotective effects of proteasome beta5 subunit overexpression in lens epithelial cells.
-
DNA copy number variants of known glaucoma genes in relation to primary open-angle glaucoma.
-
Deletion of the phosphatase INPP5E in the murine retina impairs photoreceptor axoneme formation and prevents disc morphogenesis.
-
Desensitization of G protein-coupled receptors.
-
Desensitization of the isolated beta 2-adrenergic receptor by beta-adrenergic receptor kinase, cAMP-dependent protein kinase, and protein kinase C occurs via distinct molecular mechanisms.
-
Determination of the G beta gamma-binding domain of phosducin. A regulatable modulator of G beta gamma signaling.
-
Developmental changes in carbachol-stimulated inositolphosphate release in pigmented rat retina.
-
Differential gene expression in mouse sclera during ocular development.
-
Differential response and withdrawal profile of glucocorticoid-treated human trabecular meshwork cells.
-
Directional Exosome Proteomes Reflect Polarity-Specific Functions in Retinal Pigmented Epithelium Monolayers.
-
Disease expression of RP1 mutations causing autosomal dominant retinitis pigmentosa.
-
Disruption of PAX6 function in mice homozygous for the Pax6Sey-1Neu mutation produces abnormalities in the early development and regionalization of the diencephalon.
-
Dissecting the genetics of human high myopia: a molecular biologic approach.
-
Distribution of WDR36 DNA sequence variants in patients with primary open-angle glaucoma.
-
Downregulation of a unique photoreceptor protein correlates with improper outer segment assembly.
-
Dynamin and beta-arrestin reveal distinct mechanisms for G protein-coupled receptor internalization.
-
Effect of bimatoprost on intraocular pressure in prostaglandin FP receptor knockout mice.
-
Effect of timolol on aqueous humor protein concentration in humans.
-
Efficacy of low-release-rate fluocinolone acetonide intravitreal implants to treat experimental uveitis.
-
Elovl4 5-bp-deletion knock-in mice develop progressive photoreceptor degeneration.
-
Endogenous IL-12 is required for induction and expression of experimental autoimmune uveitis.
-
Exome Sequence Analysis of 14 Families With High Myopia.
-
Experimental autoimmune uveoretinitis and pinealitis induced by interphotoreceptor retinoid-binding protein and S-antigen: induction of intraretinal and subretinal neovascularization.
-
Expression of interleukin-1 alpha, interleukin-1 beta, and an interleukin-1 receptor antagonist in human retinal pigment epithelial cells.
-
Expression of the blue-light receptor cryptochrome in the human retina.
-
Extracellular trafficking of myocilin in human trabecular meshwork cells.
-
Failure of the ILD to determine data combinability for slow loris phylogeny.
-
Fezf2 regulates telencephalic precursor differentiation from mouse embryonic stem cells.
-
Functional desensitization of the isolated beta-adrenergic receptor by the beta-adrenergic receptor kinase: potential role of an analog of the retinal protein arrestin (48-kDa protein).
-
Functional roles of the two domains of phosducin and phosducin-like protein.
-
G-protein-coupled receptors: regulatory role of receptor kinases and arrestin proteins.
-
Gene expression profile in human trabecular meshwork from patients with primary open-angle glaucoma.
-
Gene therapy for leber congenital amaurosis caused by RPE65 mutations: safety and efficacy in 15 children and adults followed up to 3 years.
-
Genetic Variants in CPA6 and PRPF31 Are Associated With Variation in Response to Metformin in Individuals With Type 2 Diabetes.
-
Genetic mapping of the beta-arrestin 1 and 2 genes on mouse chromosomes 7 and 11 respectively.
-
Genetics of adult glaucoma.
-
Genome-wide association study identifies seven novel susceptibility loci for primary open-angle glaucoma.
-
Genome-wide association study of young-onset hypertension in the Han Chinese population of Taiwan.
-
Genotype-phenotype correlations and differential diagnosis in autosomal dominant macular disease.
-
Glaucoma genetics.
-
Glaucoma in Ghana, West Africa: clinical features and the role of mutations in Myocilin.
-
Gln368STOP myocilin mutation in families with late-onset primary open-angle glaucoma.
-
Growth factor receptor-bound protein 14 undergoes light-dependent intracellular translocation in rod photoreceptors: functional role in retinal insulin receptor activation.
-
Hic-5 Regulates Actin Cytoskeletal Reorganization and Expression of Fibrogenic Markers and Myocilin in Trabecular Meshwork Cells.
-
IFN-gamma-deficient mice develop experimental autoimmune uveitis in the context of a deviant effector response.
-
Identification of a nonsense mutation at codon 128 of the Norrie's disease gene in a male infant.
-
Identification of genes expressed in a human scleral cDNA library.
-
Identification of novel genes preferentially expressed in the retina using a custom human retina cDNA microarray.
-
Identification of two novel mutations in families with X-linked ocular albinism.
-
Immunocytochemical localization of photopigments in cephalopod retinae.
-
Increasing evidence for syndromic phenotypes associated with RPGR mutations.
-
Insights into X-linked retinitis pigmentosa type 3, allied diseases and underlying pathomechanisms.
-
Interleukin 12 protects from a T helper type 1-mediated autoimmune disease, experimental autoimmune uveitis, through a mechanism involving interferon gamma, nitric oxide, and apoptosis.
-
Intravitreal Delivery of rAAV2tYF-CB-hRS1 Vector for Gene Augmentation Therapy in Patients with X-Linked Retinoschisis: 1-Year Clinical Results.
-
Isolation of retinal proteins that interact with retinitis pigmentosa GTPase regulator by interaction trap screen in yeast.
-
Isolation, culture, and characterization of endothelial cells from Schlemm's canal.
-
Isoprenylation in regulation of signal transduction by G-protein-coupled receptor kinases.
-
Isoprenylation of a protein kinase. Requirement of farnesylation/alpha-carboxyl methylation for full enzymatic activity of rhodopsin kinase.
-
Knocking out lca5 in zebrafish causes cone-rod dystrophy due to impaired outer segment protein trafficking.
-
L-DOPA is an endogenous ligand for OA1.
-
L-type calcium channels play a critical role in maintaining lens transparency by regulating phosphorylation of aquaporin-0 and myosin light chain and expression of connexins.
-
Lack of association of mutations in optineurin with disease in patients with adult-onset primary open-angle glaucoma.
-
Lifetime regulation of G protein-effector complex: emerging importance of RGS proteins.
-
Ligatin from embryonic chick neural retina.
-
Localization of three genes expressed in retina on mouse chromosome 11.
-
Low prevalence of myocilin mutations in an African American population with primary open-angle glaucoma.
-
Mechanistic basis for the failure of cone transducin to translocate: why cones are never blinded by light.
-
Mice deficient in inducible nitric oxide synthase are susceptible to experimental autoimmune uveoretinitis.
-
Microarray analysis of gene expression in adult retinal ganglion cells.
-
Misexpression of ptf1a in cortical pyramidal cells in vivo promotes an inhibitory peptidergic identity.
-
Mouse retinal pigmented epithelial cell lines retain their phenotypic characteristics after transfection with human papilloma virus: a new tool to further the study of RPE biology.
-
Multiple ciliary localization signals control INPP5E ciliary targeting.
-
Mutation screening of patients with Leber Congenital Amaurosis or the enhanced S-Cone Syndrome reveals a lack of sequence variations in the NRL gene.
-
Mutations in RPGR and RP2 account for 15% of males with simplex retinal degenerative disease.
-
Myocilin Mutations in Patients With Normal-Tension Glaucoma.
-
Myocilin and optineurin coding variants in Hispanics of Mexican descent with POAG.
-
Myocilin levels in primary open-angle glaucoma and pseudoexfoliation glaucoma human aqueous humor.
-
Myocilin mutations in black South Africans with POAG.
-
Myocilin polymorphisms and high myopia in subjects of European origin.
-
Myocilin, a component of a membrane-associated protein complex driven by a homologous Q-SNARE domain.
-
Myocilin-associated exosomes in human ocular samples.
-
Nine loci for ocular axial length identified through genome-wide association studies, including shared loci with refractive error.
-
Norrie disease gene sequence variants in an ethnically diverse population with retinopathy of prematurity.
-
North Carolina macular dystrophy (MCDR1) locus: a fine resolution genetic map and haplotype analysis.
-
Odorant receptors and desensitization proteins colocalize in mammalian sperm.
-
Onset of feedback reactions underlying vertebrate rod photoreceptor light adaptation.
-
Opsin, G-protein and 48-kDa protein in normal and rd mouse retinas: developmental expression of mRNAs and proteins and light/dark cycling of mRNAs.
-
Osteogenesis imperfecta and primary open angle glaucoma: genotypic analysis of a new phenotypic association.
-
Out-foxing fate; molecular switches create neuronal diversity in the retina.
-
Overexpression of beta-arrestin and beta-adrenergic receptor kinase augment desensitization of beta 2-adrenergic receptors.
-
PRCD Is a Small Disc-Specific Rhodopsin-Binding Protein of Unknown Function.
-
PRCD is essential for high-fidelity photoreceptor disc formation.
-
Paraneoplastic retinopathy with multiple detachments of the neurosensory retina and autoantibodies against interphotoreceptor retinoid binding protein (IRBP) in cutaneous melanoma.
-
Pentablock copolymer dexamethasone nanoformulations elevate MYOC: in vitro liberation, activity and safety in human trabecular meshwork cells.
-
Phosducin facilitates light-driven transducin translocation in rod photoreceptors. Evidence from the phosducin knockout mouse.
-
Phosducin regulates the expression of transducin betagamma subunits in rod photoreceptors and does not contribute to phototransduction adaptation.
-
Phosducin regulates transmission at the photoreceptor-to-ON-bipolar cell synapse.
-
Phosducin, potential role in modulation of olfactory signaling.
-
Phosphorylation and desensitization of the human beta 1-adrenergic receptor. Involvement of G protein-coupled receptor kinases and cAMP-dependent protein kinase.
-
Photoreceptor phosphodiesterase: interaction of inhibitory gamma subunit and cyclic GMP with specific binding sites on catalytic subunits.
-
Pigment epithelium-derived factor decreases outflow facility.
-
Pigment epithelium-derived factor supports normal Müller cell development and glutamine synthetase expression after removal of the retinal pigment epithelium.
-
Pigment epithelium-derived factor supports normal development of photoreceptor neurons and opsin expression after retinal pigment epithelium removal.
-
Polarized Exosome Release from the Retinal Pigmented Epithelium.
-
Predicting the pathogenicity of RPE65 mutations.
-
Prevalence of mutations in TIGR/Myocilin in patients with adult and juvenile primary open-angle glaucoma.
-
Prevalence of myocilin mutations in adults with primary open-angle glaucoma in Ghana, West Africa.
-
Progressive Rod-Cone Degeneration (PRCD) Protein Requires N-Terminal S-Acylation and Rhodopsin Binding for Photoreceptor Outer Segment Localization and Maintaining Intracellular Stability.
-
Prolonged dark adaptation changes connexin expression in the mouse retina.
-
Protein kinases that phosphorylate activated G protein-coupled receptors.
-
Protein profile of exosomes from trabecular meshwork cells.
-
Protein translocation in photoreceptor light adaptation: a common theme in vertebrate and invertebrate vision.
-
Proteome analysis of the rat cornea during angiogenesis.
-
Proteomic identification of unique photoreceptor disc components reveals the presence of PRCD, a protein linked to retinal degeneration.
-
Proteomic profiling of a layered tissue reveals unique glycolytic specializations of photoreceptor cells.
-
Proteomics characterization of cell membrane blebs in human retinal pigment epithelium cells.
-
Purification and characterization of the beta-adrenergic receptor kinase.
-
Putative human blue-light photoreceptors hCRY1 and hCRY2 are flavoproteins.
-
Quantitative Trait Locus Analysis of SIX1-SIX6 With Retinal Nerve Fiber Layer Thickness in Individuals of European Descent.
-
RPGR isoforms in photoreceptor connecting cilia and the transitional zone of motile cilia.
-
RPGRIP1s with distinct neuronal localization and biochemical properties associate selectively with RanBP2 in amacrine neurons.
-
Receptor-specific desensitization with purified proteins. Kinase dependence and receptor specificity of beta-arrestin and arrestin in the beta 2-adrenergic receptor and rhodopsin systems.
-
Recoverin improves rod-mediated vision by enhancing signal transmission in the mouse retina.
-
Recoverin undergoes light-dependent intracellular translocation in rod photoreceptors.
-
Regulation of myocilin-associated exosome release from human trabecular meshwork cells.
-
Retinal phenotype of an X-linked pseudo-Usher syndrome in association with the G173R mutation in the RPGR gene.
-
RhoA GTPase-induced ocular hypertension in a rodent model is associated with increased fibrogenic activity in the trabecular meshwork.
-
Rhodopsin maturation antagonized by dominant rhodopsin mutants.
-
Rhodopsin phosphorylation: from terminating single photon responses to photoreceptor dark adaptation.
-
Rhodopsin transgenic pigs as a model for human retinitis pigmentosa.
-
Role of acidic amino acids in peptide substrates of the beta-adrenergic receptor kinase and rhodopsin kinase.
-
Role of beta-arrestin in mediating agonist-promoted G protein-coupled receptor internalization.
-
Role of mouse cryptochrome blue-light photoreceptor in circadian photoresponses.
-
Screening of CYP1B1 and LTBP2 genes in Saudi families with primary congenital glaucoma: genotype-phenotype correlation.
-
Selective loss of RPGRIP1-dependent ciliary targeting of NPHP4, RPGR and SDCCAG8 underlies the degeneration of photoreceptor neurons.
-
Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction.
-
Serial analysis of gene expression (SAGE) in normal human trabecular meshwork.
-
Sex-Specific Genetic Associations for Barrett's Esophagus and Esophageal Adenocarcinoma.
-
Single origin of Malagasy Carnivora from an African ancestor.
-
Single-target molecule detection with nonbleaching multicolor optical immunolabels.
-
Sorting of lens aquaporins and connexins into raft and nonraft bilayers: role of protein homo-oligomerization.
-
Species-specific subcellular localization of RPGR and RPGRIP isoforms: implications for the phenotypic variability of congenital retinopathies among species.
-
Sphingosine-1-phosphate effects on the inner wall of Schlemm's canal and outflow facility in perfused human eyes.
-
Studying recombination with high-throughput sequencing: an educational primer for use with "fine-scale heterogeneity in crossover rate in the garnet-scalloped region of the Drosophila melanogaster X chromosome".
-
Sub-retinal drusenoid deposits in human retina: organization and composition.
-
Subacute ethanol consumption reverses p-xylene-induced decreases in axonal transport.
-
Systems Genetics Approach to Biomarker Discovery: GPNMB and Heart Failure in Mice and Humans.
-
TIGR/myocilin in human aqueous humor.
-
Tgf-beta inhibits activation and uveitogenicity of primary but not of fully polarized retinal antigen-specific memory-effector T cells.
-
The Aryl Hydrocarbon Receptor: A Mediator and Potential Therapeutic Target for Ocular and Non-Ocular Neurodegenerative Diseases.
-
The C-terminal domain of viral IAP associated factor (cVIAF) is a structural homologue of phosducin: resonance assignments and secondary structure of the C-terminal domain of VIAF.
-
The Enigma of CRB1 and CRB1 Retinopathies.
-
The LOV domain family: photoresponsive signaling modules coupled to diverse output domains.
-
The alpha-helical domain of Galphat determines specific interaction with regulator of G protein signaling 9.
-
The circadian regulatory proteins BMAL1 and cryptochromes are substrates of casein kinase Iepsilon.
-
The effects of Cenozoic global change on squirrel phylogeny.
-
The exon junction complex component Magoh controls brain size by regulating neural stem cell division.
-
The genetics of primary open-angle glaucoma: a review.
-
The receptor kinase family: primary structure of rhodopsin kinase reveals similarities to the beta-adrenergic receptor kinase.
-
The retinitis pigmentosa GTPase regulator (RPGR) interacts with novel transport-like proteins in the outer segments of rod photoreceptors.
-
The role of proteolytic cellular systems in trabecular meshwork homeostasis.
-
The structural organization and protein composition of lens fiber junctions.
-
The ubiquitous subunit of erythroid transcription factor NF-E2 is a small basic-leucine zipper protein related to the v-maf oncogene.
-
The water permeability of lens aquaporin-0 depends on its lipid bilayer environment.
-
Transcriptome analysis of adult and fetal trabecular meshwork, cornea, and ciliary body tissues by RNA sequencing.
-
Transducin gamma-subunit sets expression levels of alpha- and beta-subunits and is crucial for rod viability.
-
Transient requirement for ganglion cells during assembly of retinal synaptic layers.
-
Transplantation of full-thickness retina in the rhodopsin transgenic pig.
-
Ubiquitylation of the transducin betagamma subunit complex. Regulation by phosducin.
-
Unique response profile of trabecular meshwork cells to the novel selective glucocorticoid receptor agonist, GW870086X.
-
Visual impairment in an optineurin mouse model of primary open-angle glaucoma.
-
X-linked high myopia associated with cone dysfunction.
-
beta-Arrestin: a protein that regulates beta-adrenergic receptor function.
-
mRNAs coding for proteins of the cGMP cascade in the degenerative retina of the rd mouse.
-
mirror controls planar polarity and equator formation through repression of fringe expression and through control of cell affinities.
-
mirror encodes a novel PBX-class homeoprotein that functions in the definition of the dorsal-ventral border in the Drosophila eye.
-
Keywords of People
-
Bowes Rickman, Catherine,
George and Geneva Boguslavsky Distinguished Professor of Eye Research,
Cell Biology
-
Ferreira, Paulo Alexandre,
Associate Professor in Ophthalmology,
Pathology
-
Mruthyunjaya, Prithvi,
Adjunct Associate Professor in the Department of Ophthalmology,
Ophthalmology, Vitreoretinal Diseases & Surgery
-
Roth, V. Louise,
Professor of Biology,
Evolutionary Anthropology