Family Health

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  Subject Areas on Research

  • "Family matters": a conceptual framework for genetic testing in children. 
  • "Just three more bites": an observational analysis of parents' socialization of children's eating at mealtime. 
  • A North Carolina service for those with questions about Alzheimer disease, other memory disorders, and family care. 
  • A boy with fever and whorl keratopathy. 
  • A combined genomewide linkage scan of 1,233 families for prostate cancer-susceptibility genes conducted by the international consortium for prostate cancer genetics. 
  • A duplication in chromosome 4q35 is associated with hereditary benign intraepithelial dyskeratosis. 
  • A founder mutation in the Ashkenazi Jewish population affecting messenger RNA splicing of the CCM2 gene causes cerebral cavernous malformations. 
  • A gene for familial venous malformations maps to chromosome 9p in a second large kindred. 
  • A genome-wide search for linkage to asthma phenotypes in the genetics of asthma international network families: evidence for a major susceptibility locus on chromosome 2p. 
  • A genomewide scan for early-onset coronary artery disease in 438 families: the GENECARD Study. 
  • A germline mutation at the extreme 3' end of the APC gene results in a severe desmoid phenotype and is associated with overexpression of beta-catenin in the desmoid tumor. 
  • A human erythropoietin receptor gene mutant causing familial erythrocytosis is associated with deregulation of the rates of Jak2 and Stat5 inactivation. 
  • A locus for generalized tonic-clonic seizure susceptibility maps to chromosome 10q25-q26. 
  • A novel mutation in the erythropoietin receptor gene is associated with familial erythrocytosis. 
  • A qualitative study of family healthy lifestyle behaviors of Mexican-American and Mexican immigrant fathers and mothers. 
  • A three-generation approach in biodemography is based on the developmental profiles and the epigenetics of female gametes. 
  • Adaptation and Implementation of a Family Caregiver Skills Training Program: From Single Site RCT to Multisite Pragmatic Intervention. 
  • Adenosine deaminase deficiency with mosaicism for a "second-site suppressor" of a splicing mutation: decline in revertant T lymphocytes during enzyme replacement therapy. 
  • Age of onset in chronic major depression: relation to demographic and clinical variables, family history, and treatment response. 
  • Allergies, obesity, other risk factors and survival from pancreatic cancer. 
  • An autosomal genomic screen for dementia in an extended Amish family. 
  • Angiopoietin receptor TEK mutations underlie primary congenital glaucoma with variable expressivity. 
  • Arrhythmogenic right ventricular dysplasia: a United States experience. 
  • Assessing Acute Secondary Treatment Outcomes in Early-Onset Obsessive-Compulsive Disorder. 
  • Assessment of four stakeholder groups' preferences concerning outpatient commitment for persons with schizophrenia. 
  • Association between common germline genetic variation in 94 candidate genes or regions and risks of invasive epithelial ovarian cancer. 
  • Association between maternal education and infant diarrhea in different household and community environments of Cebu, Philippines. 
  • Association of the apolipoprotein E gene with age-related macular degeneration: possible effect modification by family history, age, and gender. 
  • Associations between Infant and Parent Characteristics and Measures of Family Well-Being in Neonates with Seizures: A Cohort Study. 
  • BRCA1 maps proximal to D17S579 on chromosome 17q21 by genetic analysis. 
  • Benefits of child-focused anxiety treatments for parents and family functioning. 
  • Birth measurements, family history, and environmental factors associated with later-life hypertensive status. 
  • Blunted cortisol responses to stress signal social and behavioral problems among maltreated/bullied 12-year-old children. 
  • Bullying victimisation and risk of self harm in early adolescence: longitudinal cohort study 
  • CD8+ T-cell alveolitis in familial pulmonary alveolar microlithiasis. 
  • Center for Child and Family Health-North Carolina. What is it? And why? 
  • Childhood sexual and physical abuse and the 1-year prevalence of medical problems in the National Comorbidity Survey. 
  • Clinical and pathologic features of familial focal segmental glomerulosclerosis. 
  • Clinical characteristics of African-American men with hereditary prostate cancer: the AAHPC Study. 
  • Clinical heterogeneity in lymphoedema-distichiasis with FOXC2 truncating mutations. 
  • Clinical manifestations and outcome of Haemophilus influenzae type b disease. 
  • Cohort Profile: FAMILY Cohort. 
  • Commentary on caring for the uninsured and underinsured. 
  • Comprehensive association analysis of APOE regulatory region polymorphisms in Alzheimer disease. 
  • Concealed medicines for people with schizophrenia: a U.S. perspective. 
  • Confirmation of a second locus for CMT2 and evidence for additional genetic heterogeneity. 
  • Confirmation of linkage of oculopharyngeal muscular dystrophy to chromosome 14q11.2-q13 in American families suggests the existence of a second causal mutation. 
  • Consumption of obesogenic foods in non-Hispanic black mother-infant dyads. 
  • Control elements within the PWS/AS imprinting box and their function in the imprinting process. 
  • Coping strategies in families of children with sickle cell disease. 
  • DNA repair related to multiple skin cancers and drug use. 
  • De novo partial duplication of chromosome 7p in a male with autistic disorder. 
  • Decreasing age at prostate cancer diagnosis over successive generations in prostate cancer families. 
  • Delayed onset of Alzheimer's disease with nonsteroidal anti-inflammatory and histamine H2 blocking drugs. 
  • Delirium tremens in acute myocardial infarction. 
  • Dementia in relation to family caregiver involvement and burden in long-term care. 
  • Deployment and mental health diagnoses among children of US Army personnel. 
  • Deployment and the use of mental health services among U.S. Army wives. 
  • Depression in elderly hospitalized patients with medical illness. 
  • Description of selected characteristics of familial glioma patients - results from the Gliogene Consortium. 
  • Development of psychiatric comorbidity with substance abuse in adolescents: effects of timing and sex. 
  • Disruption of Fgf13 causes synaptic excitatory-inhibitory imbalance and genetic epilepsy and febrile seizures plus. 
  • Domestic Violence and Families: Trauma-Focused Treatment Options. 
  • Dystonia with and without deafness is caused by TIMM8A mutation. 
  • Effects of a Rural Family Drug Treatment Court Collaborative on Child Welfare Outcomes: Comparison Using Propensity Score Analysis. 
  • Ethnic identity and type 2 diabetes health attitudes in Americans of African ancestry. 
  • Evidence for the segregation of a major gene for human plasma GABA levels. 
  • Exclusion of homozygous PLCE1 (NPHS3) mutations in 69 families with idiopathic and hereditary FSGS. 
  • Exploring the association of glyceraldehyde-3-phosphate dehydrogenase gene and Alzheimer disease. 
  • Familial dermatomyositis. 
  • Familial eccrine syringofibroadenomatosis with associated ophthalmologic abnormalities. 
  • Familial variable expression of dilated cardiomyopathy in Alström syndrome: a report of four sibs. 
  • Familiality of quantitative metabolic traits in Finnish families with non-insulin-dependent diabetes mellitus. Finland-United States Investigation of NIDDM Genetics (FUSION) Study investigators. 
  • Family Spirituality and Family Health Among Korean-American Elderly Couples. 
  • Family and personal medical history and risk of meningioma. 
  • Family diabetes matters: a view from the other side. 
  • Family history and TOMM40 '523 interactive associations with memory in middle-aged and Alzheimer's disease cohorts. 
  • Family history as a marker of platinum sensitivity in pancreatic adenocarcinoma. 
  • Family history of cancer and risk of sporadic differentiated thyroid carcinoma. 
  • Family history of cancer: pooled analysis in the International Head and Neck Cancer Epidemiology Consortium. 
  • Family history of mood disorder and characteristics of major depressive disorder: a STAR*D (sequenced treatment alternatives to relieve depression) study. 
  • Family history of prostate cancer and relapse after definitive external beam radiation therapy. 
  • Family pain history predicts child health status in children with chronic rheumatic disease. 
  • Family-Based Genome-Wide Association Study of South Indian Pedigrees Supports WNT7B as a Central Corneal Thickness Locus. 
  • Family-based case-control study of MAOA and MAOB polymorphisms in Parkinson disease. 
  • Family-based youth mental health interventions delivered by nonspecialist providers in low- and middle-income countries: A systematic review. 
  • Food Insecurity Was Associated With Greater Family Health Care Expenditures In The US, 2016-17. 
  • Further exclusion of FSHD1B from the telomeric region of 10q. 
  • Genetic counseling and testing for breast-ovarian cancer susceptibility: what do women want? 
  • Genome-wide high-density SNP linkage search for glioma susceptibility loci: results from the Gliogene Consortium. 
  • Genome-wide scan for adult onset primary open angle glaucoma. 
  • Health consequences of familial longevity influence among the Chinese elderly. 
  • Health-related quality of life of children with acute lymphoblastic leukaemia: comparisons and correlations between parent and clinician reports. 
  • Hereditary link: scientists seek clues in genetic risks for prostate cancer. 
  • Heritability of functioning in families with schizophrenia in relation to neurocognition. 
  • High heritability of metabolomic profiles in families burdened with premature cardiovascular disease. 
  • How COVID-19 impacted child and family health and healthcare: a mixed-methods study incorporating family voices. 
  • How Incarceration Affects the Health of Communities and Families. 
  • How does family drug treatment court participation affect child welfare outcomes? 
  • Human Gut Microbiota Predicts Susceptibility to Vibrio cholerae Infection. 
  • Hypercholesterolemia and prostate cancer: a hospital-based case-control study. 
  • ISPAD Guidelines. Managing diabetes in preschool children. 
  • Identification of a novel germline SPOP mutation in a family with hereditary prostate cancer. 
  • Identification of a novel mutation (C321X) in HJV. 
  • Identification of novel genes in late-onset Alzheimer's disease. 
  • Identification of risk and age-at-onset genes on chromosome 1p in Parkinson disease. 
  • Implementation and dissemination of military informed and evidence-based interventions for community dwelling military families. 
  • Implementation of health risk assessments with family health history: barriers and benefits. 
  • Implementation of the Texas Medication Algorithm Project patient and family education program. 
  • Incarceration, maternal hardship, and perinatal health behaviors. 
  • Inference on haplotype/disease association using parent-affected-child data: the projection conditional on parental haplotypes method. 
  • Inter-generational continuity in periodontal health: findings from the Dunedin family history study. 
  • Interleukin 7 receptor alpha chain (IL7R) shows allelic and functional association with multiple sclerosis. 
  • Interpreting analyses of continuous covariates in affected sibling pair linkage studies. 
  • Intragenic modifiers of hereditary spastic paraplegia due to spastin gene mutations. 
  • Lack of association between UBQLN1 and Alzheimer disease. 
  • Lack of association between autism and SLC25A12. 
  • Li-Fraumeni syndrome: report of a clinical research workshop and creation of a research consortium. 
  • Linkage analysis of candidate myelin genes in familial multiple sclerosis. 
  • Linkage and association analysis of chromosome 19q13 in multiple sclerosis. 
  • Linkage and association with the NOS2A locus on chromosome 17q11 in multiple sclerosis. 
  • Linkage disequilibrium and haplotype tagging polymorphisms in the Tau H1 haplotype. 
  • Linkage disequilibrium at the Angelman syndrome gene UBE3A in autism families. 
  • Linkage of familial Wilms' tumor predisposition to chromosome 19 and a two-locus model for the etiology of familial tumors. 
  • Locus heterogeneity, anticipation and reduction of the chromosome 2p minimal candidate region in autosomal dominant familial spastic paraplegia. 
  • Maternal depression and children's antisocial behavior: nature and nurture effects. 
  • Maternal homozygosity for the common MTHFR mutation as a potential risk factor for offspring with limb defects. 
  • Maternal work hours and adolescents' school outcomes among low-income families in four urban counties. 
  • Memory B cell responses to Vibrio cholerae O1 lipopolysaccharide are associated with protection against infection from household contacts of patients with cholera in Bangladesh. 
  • Meta-analysis of age at onset in spastin-associated hereditary spastic paraplegia provides no evidence for a correlation with mutational class. 
  • Methods for interaction analyses using family-based case-control data: conditional logistic regression versus generalized estimating equations. 
  • Multilocus mapping of the X-linked hypophosphatemic rickets gene. 
  • Mutation of MYH9, encoding non-muscle myosin heavy chain A, in May-Hegglin anomaly. 
  • Mutations in NGLY1 cause an inherited disorder of the endoplasmic reticulum-associated degradation pathway. 
  • Mutations in UPF3B, a member of the nonsense-mediated mRNA decay complex, cause syndromic and nonsyndromic mental retardation. 
  • NOS2A and the modulating effect of cigarette smoking in Parkinson's disease. 
  • No genetic association between the LRP receptor and sporadic or late-onset familial Alzheimer disease. 
  • Offspring of patients with diabetes exhibit a clustering of psychosocial distress and inflammatory and metabolic risk factors. 
  • Ordered-subset analysis of savant skills in autism for 15q11-q13. 
  • Pairing nurses and social workers in schools: North Carolina’s school-based child and family support teams. 
  • Parent-adolescent relationship quality as a moderator of links between COVID-19 disruption and reported changes in mothers' and young adults' adjustment in five countries. 
  • Parental history of hypertension is associated with narrower retinal arteriolar caliber in young girls. 
  • Parents' information and support needs when their child is diagnosed with type 1 diabetes: a qualitative study. 
  • Participation in a women's breast cancer risk counseling trial. Who participates? Who declines? High Risk Breast Cancer Consortium. 
  • Pathways: a school-based, randomized controlled trial for the prevention of obesity in American Indian schoolchildren. 
  • Patient selection for hemiablative focal therapy of prostate cancer: variables predictive of tumor unilaterality based upon radical prostatectomy. 
  • Patient's lung cancer diagnosis as a cue for relatives' smoking cessation: evaluating the constructs of the teachable moment. 
  • Pelvic Inflammatory Disease and the Risk of Ovarian Cancer and Borderline Ovarian Tumors: A Pooled Analysis of 13 Case-Control Studies. 
  • Perception of friends' use of alcohol, cigarettes, and marijuana among urban schoolchildren: a longitudinal analysis. 
  • Phenotypic analysis of 303 multiplex families with common epilepsies. 
  • Polygenic transmission disequilibrium confirms that common and rare variation act additively to create risk for autism spectrum disorders. 
  • Possible bipolar nature of irritability in major depressive disorder. 
  • Precocious osteoarthritis in a family with recurrent COL2A1 mutation. 
  • Predictors of parental accommodation in pediatric obsessive-compulsive disorder: findings from the Pediatric Obsessive-Compulsive Disorder Treatment Study (POTS) trial. 
  • Prevalence of deleterious ATM germline mutations in gastric cancer patients. 
  • Prevalence, correlates, and course of minor depression and major depression in the National Comorbidity Survey. 
  • Problematic alcohol use among fathers in Kenya: Poverty, people, and practices as barriers and facilitators to help acceptance. 
  • Promoting healthful family meals to prevent obesity: HOME Plus, a randomized controlled trial. 
  • Protocol for implementation of family health history collection and decision support into primary care using a computerized family health history system. 
  • Providing patient education: impact on quantity and quality of family health history collection. 
  • Quality of family history collection with use of a patient facing family history assessment tool. 
  • Quality of life of patients with otitis media and caregivers: a multicenter study. 
  • Quantitative and qualitative differences in the T cell response to HIV in uninfected Ugandans exposed or unexposed to HIV-infected partners. 
  • R726L androgen receptor mutation is uncommon in prostate cancer families in the united states. 
  • RAS mutations in thyroid FNA specimens are highly predictive of predominantly low-risk follicular-pattern cancers. 
  • RNASEL mutations in hereditary prostate cancer. 
  • Racial differences in prostate cancer screening by family history. 
  • Racial differences in the interaction between family history and risk factors associated with diabetes in the National Health and Nutritional Examination Survey, 1999-2004. 
  • Rare functional genetic variants in COL7A1, COL6A5, COL1A2 and COL5A2 frequently occur in Chiari Malformation Type 1. 
  • Reconsidering the family history in primary care. 
  • Refinement of the PARK3 locus on chromosome 2p13 and the analysis of 14 candidate genes. 
  • Refractory calculation-induced idiopathic generalized epilepsy: a case report and review of the literature. 
  • Relationship of nutritional status to health and societal participation in children with cerebral palsy. 
  • Religiosity and Physician Lifestyle from a Family Health Strategy. 
  • Resettlement, mental health, and coping: a mixed methods survey with recently resettled refugee parents in Canada. 
  • Retinal microvessels reflect familial vulnerability to psychotic symptoms: A comparison of twins discordant for psychotic symptoms and controls. 
  • Revised PORT recommendations. 
  • Risk factors for febrile status epilepticus: a case-control study. 
  • SCN5A variant that blocks fibroblast growth factor homologous factor regulation causes human arrhythmia. 
  • Segregation analysis in cutaneous malignant melanoma/dysplastic nevus syndrome families. 
  • Sequence variation in alpha-methylacyl-CoA racemase and risk of early-onset and familial prostate cancer. 
  • Shift work disorder case studies: applying management principles in clinical practice. 
  • Smoking, caffeine, and nonsteroidal anti-inflammatory drugs in families with Parkinson disease. 
  • Social context of pain in children with Juvenile Primary Fibromyalgia Syndrome: parental pain history and family environment. 
  • Social issues of the Alzheimer's patient and family. 
  • Strategies and tactics in the management of maintenance treatment for depressed patients. 
  • Subtelomeric deletions of chromosome 6p: molecular and cytogenetic characterization of three new cases with phenotypic overlap with Ritscher-Schinzel (3C) syndrome. 
  • T locus shows no evidence for linkage disequilibrium or mutation in American Caucasian neural tube defect families. 
  • The Great Smoky Mountains Study of Youth. Goals, design, methods, and the prevalence of DSM-III-R disorders. 
  • The Survival of Spouses Marrying Into Longevity-Enriched Families. 
  • The alpha-synuclein gene is not a major risk factor in familial Parkinson disease. 
  • The benefits of motivational interviewing and coaching for improving the practice of comprehensive family assessments in child welfare. 
  • The burden of Parkinson's disease on society, family, and the individual. 
  • The caregiving environments provided to children by depressed mothers with or without an antisocial history. 
  • The costs of schizophrenia. 
  • The effect of a telephone family assessment intervention on the functional health of patients with elevated family stress. 
  • The effect of parental history of myopia on eye size of pre-school children: a pilot study. 
  • The family routines inventory: theoretical origins. 
  • The genetic component of discrete disability traits: an analysis using liability models with age-dependent thresholds. 
  • The healthy families act: vital support for families of people with developmental disabilities. 
  • The moderating effects of children's fear and activity level on relations between parenting practices and childhood symptomatology. 
  • The role of social support in families coping with childhood brain tumor. 
  • Truncating BRCA1 mutations are uncommon in a cohort of hereditary prostate cancer families with evidence of linkage to 17q markers. 
  • Two common endoglin mutations in families with hereditary hemorrhagic telangiectasia in the Netherlands Antilles: evidence for a founder effect. 
  • Two new familial severe infantile spasm syndromes in males. 
  • Use of a patient-entered family health history tool with decision support in primary care: impact of identification of increased risk patients on genetic counseling attendance. 
  • Use of complementary and alternative medicine in men with family history of prostate cancer: a pilot study. 
  • Validation of the phenomenon of autistic regression using home videotapes. 
  • Variable presentation of nemaline myopathy: novel mutation of alpha actin gene. 
  • WHIM syndrome caused by a single amino acid substitution in the carboxy-tail of chemokine receptor CXCR4. 
  • Weight control practices and disordered eating behaviors among adolescent females and males with type 1 diabetes: associations with sociodemographics, weight concerns, familial factors, and metabolic outcomes. 
  • Whole genomewide linkage screen for neural tube defects reveals regions of interest on chromosomes 7 and 10. 
  • X-linked lissencephaly in an Indian family. 
  • [Dialogues on the work process in oral health in Brazil: an analysis based on the PMAQ-AB survey]. 
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  Keywords of People

  • Clements III, Dennis Alfred, Professor Emeritus of Pediatrics, Pediatrics, General Pediatrics and Adolescent Health
  • Orlando, Lori Ann, Professor of Medicine, Medicine, General Internal Medicine
  • Schanberg, Laura Eve, Professor of Pediatrics, Pediatrics, Rheumatology