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Subject Areas on Research
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A Liver-Specific Thyromimetic, VK2809, Decreases Hepatosteatosis in Glycogen Storage Disease Type Ia.
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A link between leptin and steatosis in chronic hepatitis C? Time to weigh up the fats.
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A20 protects mice from lethal liver ischemia/reperfusion injury by increasing peroxisome proliferator-activated receptor-alpha expression.
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AST to ALT ratio and arterial stiffness in non-fatty liver Japanese population:a secondary analysis based on a cross-sectional study.
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Accumulation of natural killer T cells in progressive nonalcoholic fatty liver disease.
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Accuracy of Automated Liver Contouring, Fat Fraction, and R2* Measurement on Gradient Multiecho Magnetic Resonance Images.
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Activation of nuclear receptor CAR ameliorates diabetes and fatty liver disease.
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Acute encephalopathy and fatty hepatomegaly.
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Acute fatty liver of pregnancy and long-chain 3-hydroxyacyl-coenzyme A dehydrogenase deficiency.
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Acute fatty liver of pregnancy associated with short-chain acyl-coenzyme A dehydrogenase deficiency.
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Acute fatty liver of pregnancy, hemolysis, elevated liver enzymes, and low platelets syndrome, and long chain 3-hydroxyacyl-coenzyme A dehydrogenase deficiency.
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After goodbye? Dead hepatocytes as a biomarker for fibrosis and steatohepatitis.
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Alcohollike liver disease in nonalcoholics. A clinical and histologic comparison with alcohol-induced liver injury.
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Alterations in liver ATP homeostasis in human nonalcoholic steatohepatitis: a pilot study.
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Altered hepatic lymphocyte subpopulations in obesity-related murine fatty livers: potential mechanism for sensitization to liver damage.
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Alternative splicing in Acad8 resulting a mitochondrial defect and progressive hepatic steatosis in mice.
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Animal models of steatohepatitis.
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Animal models of steatosis.
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Apoptosis and cytokines in non-alcoholic steatohepatitis.
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Assessment of intrahepatic triglyceride content using magnetic resonance spectroscopy.
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Association between puberty and features of nonalcoholic fatty liver disease.
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Associations of depression, anxiety and antidepressants with histological severity of nonalcoholic fatty liver disease.
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Automated liver sampling using a gradient dual-echo Dixon-based technique.
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Automated patient-tailored screening of the liver for diffuse steatosis and iron overload using MRI.
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Beneficial IL28B genotype associated with lower frequency of hepatic steatosis in patients with chronic hepatitis C.
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Breath biomarkers and non-alcoholic fatty liver disease: preliminary observations.
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CCAAT/enhancer-binding protein beta deletion reduces adiposity, hepatic steatosis, and diabetes in Lepr(db/db) mice.
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CYP2E1 activity before and after weight loss in morbidly obese subjects with nonalcoholic fatty liver disease.
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CYP2E1-dependent and leptin-mediated hepatic CD57 expression on CD8+ T cells aid progression of environment-linked nonalcoholic steatohepatitis.
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Cafeteria diet is a robust model of human metabolic syndrome with liver and adipose inflammation: comparison to high-fat diet.
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Caffeine stimulates hepatic lipid metabolism by the autophagy-lysosomal pathway in mice.
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Carbohydrate restriction, prostate cancer growth, and the insulin-like growth factor axis.
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Cases from the Osler Medical Service at Johns Hopkins University. Zieve syndrome.
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ChREBP regulates fructose-induced glucose production independently of insulin signaling.
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Choline intake in a large cohort of patients with nonalcoholic fatty liver disease.
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Chronological development of elevated aminotransferases in a nonalcoholic population.
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Clinical correlates of histopathology in pediatric nonalcoholic steatohepatitis.
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Clinical update on screening, diagnosis and management of metabolic disorders and cardiovascular risk factors associated with polycystic ovary syndrome.
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Clinical, laboratory and histological associations in adults with nonalcoholic fatty liver disease.
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Comparison of noninvasive markers of fibrosis in patients with nonalcoholic fatty liver disease.
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Comparison of the frequency of coronary artery disease in alcohol-related versus non-alcohol-related endstage liver disease.
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Complications of human immunodeficiency virus therapy.
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Correlation of vitamin E, uric acid, and diet composition with histologic features of pediatric NAFLD.
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Costaining for keratins 8/18 plus ubiquitin improves detection of hepatocyte injury in nonalcoholic fatty liver disease.
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Critical role of FoxO3a in alcohol-induced autophagy and hepatotoxicity.
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Cytokine network during NASH and possible treatment selection.
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Cytokine regulation of liver injury and repair.
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Cytokines and the pathogenesis of non-alcoholic steatohepatitis.
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Cytokines in alcoholic and nonalcoholic steatohepatitis.
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De novo nonalcoholic fatty liver disease after liver transplantation.
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Defining nonalcoholic fatty liver disease: implications for epidemiologic studies.
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Deletion of CaMKK2 from the liver lowers blood glucose and improves whole-body glucose tolerance in the mouse.
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Derivation and analysis of viscoelastic properties in human liver: impact of frequency on fibrosis and steatosis staging.
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Development of a Scoring System to Differentiate Amiodarone-Induced Liver Injury From Alcoholic Steatohepatitis.
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Diacylglycerol acyltranferase 1 anti-sense oligonucleotides reduce hepatic fibrosis in mice with nonalcoholic steatohepatitis.
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Diagnosis of nonalcoholic fatty liver disease.
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Diet and exercise interventions reduce intrahepatic fat content and improve insulin sensitivity in obese older adults.
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Dietary composition and nonalcoholic fatty liver disease.
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Dietary factors alter hepatic innate immune system in mice with nonalcoholic fatty liver disease.
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Disrupted signaling and inhibited regeneration in obese mice with fatty livers: implications for nonalcoholic fatty liver disease pathophysiology.
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Disruption of Gpr45 causes reduced hypothalamic POMC expression and obesity.
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Dissociation of hepatic steatosis and insulin resistance in mice overexpressing DGAT in the liver.
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Dual gradient-echo in-phase and opposed-phase hepatic MR imaging: a useful tool for evaluating more than fatty infiltration or fatty sparing.
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ENU mutagenesis identifies mice with cardiac fibrosis and hepatic steatosis caused by a mutation in the mitochondrial trifunctional protein beta-subunit.
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Effect of a 12-month intensive lifestyle intervention on hepatic steatosis in adults with type 2 diabetes.
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Effect of apolipoproteins on the induction of hepatic steatosis in rats.
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Effect of changes on body weight and lifestyle in nonalcoholic fatty liver disease.
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Elevated hepatocyte levels of the Forkhead box A2 (HNF-3beta) transcription factor cause postnatal steatosis and mitochondrial damage.
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Elevated serum CK18 levels in chronic hepatitis C patients are associated with advanced fibrosis but not steatosis.
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Endoplasmic reticulum stress, hepatocyte CD1d and NKT cell abnormalities in murine fatty livers.
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Environmental toxin-linked nonalcoholic steatohepatitis and hepatic metabolic reprogramming in obese mice.
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Epigallocatechin-3-gallate (EGCG), a green tea polyphenol, stimulates hepatic autophagy and lipid clearance.
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Factors Associated With Persistent Increase in Level of Alanine Aminotransferase in Patients With Chronic Hepatitis B Receiving Oral Antiviral Therapy.
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Fat and the liver--a molecular overview.
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Fatty liver vulnerability to endotoxin-induced damage despite NF-kappaB induction and inhibited caspase 3 activation.
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Fatty liver, hypertension, and the metabolic syndrome.
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Focal fatty infiltration: a cause of nontumorous defects in the left hepatic lobe during CT arterial portography.
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Fructose consumption as a risk factor for non-alcoholic fatty liver disease.
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Gender and menopause impact severity of fibrosis among patients with nonalcoholic steatohepatitis.
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Genetic differences in oxidative stress and inflammatory responses to diet-induced obesity do not alter liver fibrosis in mice.
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Genetic signatures in choline and 1-carbon metabolism are associated with the severity of hepatic steatosis.
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Genetic susceptibility to hepatic steatosis.
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Genome-wide association analysis identifies variants associated with nonalcoholic fatty liver disease that have distinct effects on metabolic traits.
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Genotype 3 Infection: The Last Stand of Hepatitis C Virus.
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Hedgehog pathway activation parallels histologic severity of injury and fibrosis in human nonalcoholic fatty liver disease.
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Hedgehog pathway and pediatric nonalcoholic fatty liver disease.
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Hedgehog-mediated epithelial-to-mesenchymal transition and fibrogenic repair in nonalcoholic fatty liver disease.
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Hepatic ATP reserve and efficiency of replenishing: comparison between obese and nonobese normal individuals.
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Hepatic MR imaging for in vivo differentiation of steatosis, iron deposition and combined storage disorder: single-ratio in/opposed phase analysis vs. dual-ratio Dixon discrimination.
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Hepatic accumulation of Hedgehog-reactive progenitors increases with severity of fatty liver damage in mice.
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Hepatic acyl-CoA:diacylglcyerol acyltransferase (DGAT) overexpression, diacylglycerol, and insulin sensitivity.
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Hepatic complications of obesity.
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Hepatic complications of obesity.
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Hepatic fat and adenosine triphosphate measurement in overweight and obese adults using 1H and 31P magnetic resonance spectroscopy.
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Hepatic fibrosis associated with aging in four stocks of mice.
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Hepatic gene expression profiles differentiate presymptomatic patients with mild versus severe nonalcoholic fatty liver disease.
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Hepatic hyperplasia in noncirrhotic fatty livers: is obesity-related hepatic steatosis a premalignant condition?
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Hepatic insulin signaling is required for obesity-dependent expression of SREBP-1c mRNA but not for feeding-dependent expression.
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Hepatic overexpression of glycerol-sn-3-phosphate acyltransferase 1 in rats causes insulin resistance.
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Hepatic steatosis and type 2 diabetes mellitus.
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Hepatic triglyceride synthesis and nonalcoholic fatty liver disease.
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Hepatitis C and steatosis.
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Hyaluronic acid, an accurate serum marker for severe hepatic fibrosis in patients with non-alcoholic fatty liver disease.
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Hypoxia Signaling Cascade for Erythropoietin Production in Hepatocytes.
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IL28B rs12979860 is not associated with histologic features of NAFLD in a cohort of Caucasian North American patients.
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Idiopathic hyperammonemia following an unrelated cord blood transplant for mucopolysaccharidosis I.
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Impact of steatosis on perioperative outcome following hepatic resection.
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Incorporation of palmitate-1-14C into liver lipids of rats fed millet (Sorghum vulgarie) at different protein levels.
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Increased Hepatic Fat Content in Patients with Resistance to Thyroid Hormone Beta.
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Increased fructose consumption is associated with fibrosis severity in patients with nonalcoholic fatty liver disease.
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Increased gastrointestinal ethanol production in obese mice: implications for fatty liver disease pathogenesis.
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Increased production of sonic hedgehog by ballooned hepatocytes.
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Influence of gender, race, and ethnicity on suspected fatty liver in obese adolescents.
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Inhibiting triglyceride synthesis improves hepatic steatosis but exacerbates liver damage and fibrosis in obese mice with nonalcoholic steatohepatitis.
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Insulin resistance and altered systemic glucose metabolism in mice lacking Nur77.
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Insulin resistance and steatosis in hepatitis C virus infection.
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Insulin resistance syndrome and nonalcoholic fatty liver disease.
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Intermittent disconjugate gaze: a novel finding in nonalcoholic steatohepatitis and cryptogenic cirrhosis.
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Is liver biopsy useful in the evaluation of patients with chronically elevated liver enzymes?
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KLF15 is a molecular link between endoplasmic reticulum stress and insulin resistance.
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Leptin is key to peroxynitrite-mediated oxidative stress and Kupffer cell activation in experimental non-alcoholic steatohepatitis.
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Light to moderate alcohol consumption is associated with lower frequency of hypertransaminasemia.
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Linearity and Bias of Proton Density Fat Fraction as a Quantitative Imaging Biomarker: A Multicenter, Multiplatform, Multivendor Phantom Study.
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Lipoatrophic diabetes and end-stage liver disease secondary to nonalcoholic steatohepatitis with recurrence after liver transplantation.
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Liver disease in pregnancy.
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Liver disease in pregnancy.
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Liver disease in pregnancy.
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Liver fat quantification using a multi-step adaptive fitting approach with multi-echo GRE imaging.
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Liver regeneration in obese mice with fatty livers: does the impairment have relevance for other types of fatty liver disease?
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Liver-specific deletion of augmenter of liver regeneration accelerates development of steatohepatitis and hepatocellular carcinoma in mice.
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Low-dose unenhanced CT for IV contrast bolus timing: is it reliable to assess hepatic steatosis?
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Lower serum hepcidin and greater parenchymal iron in nonalcoholic fatty liver disease patients with C282Y HFE mutations.
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Measurement of fat/water ratios in rat liver using 3D three-point dixon MRI.
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Mechanisms of disease progression in NASH: new paradigms.
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Mechanisms of disease progression in nonalcoholic fatty liver disease.
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Mechanisms of ischemic injury are different in the steatotic and normal rat liver.
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Metabolic syndrome and liver steatosis occur at lower body mass index in US Asian patients with chronic hepatitis B.
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Metformin reverses fatty liver disease in obese, leptin-deficient mice.
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Mild donor liver steatosis has no impact on hepatitis C virus fibrosis progression following liver transplantation.
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Mitochondrial adaptations to obesity-related oxidant stress.
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Mitochondrial glycerol-3-phosphate acyltransferase-1 is essential in liver for the metabolism of excess acyl-CoAs.
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Mitochondrial proteins that regulate apoptosis and necrosis are induced in mouse fatty liver.
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Multinodular focal fatty infiltration of the liver: atypical imaging findings on delayed T1-weighted Gd-BOPTA-enhanced liver-specific MR images.
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Murine leptin deficiency alters Kupffer cell production of cytokines that regulate the innate immune system.
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Myocardial infarction and coronary artery dissection in pregnancy.
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NAFLD and extrahepatic cancers: have a look at the colon.
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NAFLD, NASH and liver cancer.
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NASH and cryptogenic cirrhosis: a histological analysis.
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NKT-associated hedgehog and osteopontin drive fibrogenesis in non-alcoholic fatty liver disease.
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No significant effects of ethyl-eicosapentanoic acid on histologic features of nonalcoholic steatohepatitis in a phase 2 trial.
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Non-alcoholic fatty liver disease: lumen-liver interactions and possible role for probiotics.
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Non-alcoholic steatohepatitis pathogenesis: role of repair in regulating the disease progression.
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Nonalcoholic fatty liver disease as a complication of insulin resistance.
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Nonalcoholic fatty liver disease in women.
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Nonalcoholic fatty liver disease.
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Nonalcoholic fatty liver disease: an agenda for clinical research.
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Nonalcoholic fatty liver disease: an underrecognized cause of cryptogenic cirrhosis.
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Nonalcoholic fatty liver disease: implications for alcoholic liver disease pathogenesis.
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Nonalcoholic steatohepatitis and nonalcoholic Fatty liver disease in young women with polycystic ovary syndrome.
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Nonalcoholic steatohepatitis.
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Nonalcoholic steatosis and steatohepatitis IV. Nonalcoholic fatty liver disease abnormalities in macrophage function and cytokines.
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Noninvasive evaluation of hepatic fibrosis using acoustic radiation force-based shear stiffness in patients with nonalcoholic fatty liver disease.
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Norepinephrine regulates hepatic innate immune system in leptin-deficient mice with nonalcoholic steatohepatitis.
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Obese humans with nonalcoholic fatty liver disease display alterations in fecal microbiota and volatile organic compounds.
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Obesity and female gender increase breath ethanol concentration: potential implications for the pathogenesis of nonalcoholic steatohepatitis.
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Obesity increases sensitivity to endotoxin liver injury: implications for the pathogenesis of steatohepatitis.
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Osteopontin is induced by hedgehog pathway activation and promotes fibrosis progression in nonalcoholic steatohepatitis.
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Oval cells compensate for damage and replicative senescence of mature hepatocytes in mice with fatty liver disease.
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Oxidative DNA damage and DNA repair enzyme expression are inversely related in murine models of fatty liver disease.
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Oxidative stress and oval cell accumulation in mice and humans with alcoholic and nonalcoholic fatty liver disease.
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PPDPF alleviates hepatic steatosis through inhibition of mTOR signaling.
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Pan-caspase inhibitor VX-166 reduces fibrosis in an animal model of nonalcoholic steatohepatitis.
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Paracrine Hedgehog signaling drives metabolic changes in hepatocellular carcinoma.
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Patatin-like phospholipase domain-containing protein 3 and liver disease: opportunities to unravel mechanisms underlying statistical associations.
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Pathogenesis of hepatic steatosis in the parenterally fed rat.
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Persistent liver biochemistry abnormalities are more common in older patients and those with cholestatic drug induced liver injury.
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Phosphatase and tensin homolog (PTEN) regulates hepatic lipogenesis, microsomal triglyceride transfer protein, and the secretion of apolipoprotein B-containing lipoproteins.
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Physical activity recommendations, exercise intensity, and histological severity of nonalcoholic fatty liver disease.
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Pilot study assessing differentiation of steatosis hepatis, hepatic iron overload, and combined disease using two-point dixon MRI at 3 T: in vitro and in vivo results of a 2D decomposition technique.
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Pioglitazone, vitamin E, or placebo for nonalcoholic steatohepatitis.
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Polycystic ovary syndrome and severe nonalcoholic steatohepatitis: beneficial effect of modest weight loss and exercise on liver biopsy findings.
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Portal chronic inflammation in nonalcoholic fatty liver disease (NAFLD): a histologic marker of advanced NAFLD-Clinicopathologic correlations from the nonalcoholic steatohepatitis clinical research network.
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Pre-transplant hepatic steatosis (fatty liver) is associated with chronic graft-vs-host disease but not mortality.
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Prediction of Recurrence Patterns from Hepatic Parenchymal Disease After Resection of Colorectal Liver Metastases.
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Prenatal sensitization of a postnatal trigger for metabolic disease.
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Prevalence and indicators of portal hypertension in patients with nonalcoholic fatty liver disease.
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Probiotics and antibodies to TNF inhibit inflammatory activity and improve nonalcoholic fatty liver disease.
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Purinergic receptor X7 is a key modulator of metabolic oxidative stress-mediated autophagy and inflammation in experimental nonalcoholic steatohepatitis.
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Quality of life in adults with nonalcoholic fatty liver disease: baseline data from the nonalcoholic steatohepatitis clinical research network.
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Quantification of hepatic steatosis with a multistep adaptive fitting MRI approach: prospective validation against MR spectroscopy.
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Race and comorbid factors predict nonalcoholic fatty liver disease histopathology in severely obese patients.
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Recurrence of nonalcoholic steatohepatitis in a liver transplant recipient.
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Regional anthropometric measures and hepatic fibrosis in patients with nonalcoholic Fatty liver disease.
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Relationship between adipose tissue insulin resistance and liver histology in nonalcoholic steatohepatitis: a pioglitazone versus vitamin E versus placebo for the treatment of nondiabetic patients with nonalcoholic steatohepatitis trial follow-up study.
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Relationship between methylome and transcriptome in patients with nonalcoholic fatty liver disease.
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Reply: To PMID 23913408.
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Reply: To PMID 24123276.
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Reye's syndrome treated by peritoneal dialysis.
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Reye's syndrome. Possible causes and pathogenetic pathways.
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Role of inflammation in nonalcoholic steatohepatitis.
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Roux-en-Y gastric bypass improves liver histology in patients with non-alcoholic fatty liver disease.
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STAT-3 overexpression and p21 up-regulation accompany impaired regeneration of fatty livers.
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Scintigraphy, ultrasound and CT scanning of the liver.
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Serum hepatic enzyme and bilirubin elevations during parenteral nutrition.
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Should nonalcoholic fatty liver disease be treated differently in elderly patients?
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Signals from dying hepatocytes trigger growth of liver progenitors.
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Similarities and differences in the pathogenesis of alcoholic and nonalcoholic steatohepatitis.
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Specific polymorphisms in hepatitis C virus genotype 3 core protein associated with intracellular lipid accumulation.
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Steatosis and chronic hepatitis C virus infection: mechanisms and significance.
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Steatosis is an independent predictor of relapse following rapid virologic response in patients with HCV genotype 3.
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Sympathetic nervous system inhibition increases hepatic progenitors and reduces liver injury.
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Temporal dynamics of liver mitochondrial protein acetylation and succinylation and metabolites due to high fat diet and/or excess glucose or fructose.
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The FGF21 response to fructose predicts metabolic health and persists after bariatric surgery in obese humans.
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The association of genetic variants with hepatic steatosis in patients with genotype 1 chronic hepatitis C infection.
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The diagnosis and management of non-alcoholic fatty liver disease: Practice guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological Association.
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The diagnosis and management of non-alcoholic fatty liver disease: practice Guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological Association.
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The diagnosis and management of non-alcoholic fatty liver disease: practice guideline by the American Gastroenterological Association, American Association for the Study of Liver Diseases, and American College of Gastroenterology.
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The effect of a low-carbohydrate, ketogenic diet on nonalcoholic fatty liver disease: a pilot study.
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The effect of a probiotic on hepatic steatosis.
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The effect of choline supplementation on hepatic steatosis in the parenterally fed rat.
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The effects of varying dietary carbohydrate and fat content on survival in a murine LNCaP prostate cancer xenograft model.
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The glucagon-like peptide-1 receptor agonist Exendin 4 has a protective role in ischemic injury of lean and steatotic liver by inhibiting cell death and stimulating lipolysis.
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The impact of steatosis on disease progression and early and sustained treatment response in chronic hepatitis C patients.
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The importance of routine liver biopsy in diagnosing nonalcoholic steatohepatitis in bariatric patients.
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The liver in obesity and type 2 diabetes mellitus.
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The predictive value of donor liver biopsies for the development of primary nonfunction after orthotopic liver transplantation.
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The predictive value of donor liver biopsies on the development of primary nonfunction after orthotopic liver transplantation.
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The prevalence and etiology of elevated aminotransferase levels in the United States.
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The problem of establishing relationships between hepatic steatosis and hepatic insulin resistance.
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Treatment of nonalcoholic fatty liver disease in children: TONIC trial design.
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Tumor necrosis factor and its potential role in insulin resistance and nonalcoholic fatty liver disease.
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Values and limitations of serum aminotransferases in clinical trials of nonalcoholic steatohepatitis.
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Keywords of People
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Amin, Mansi D,
Assistant Professor of Pediatrics,
Pediatrics, Gastroenterology, Hepatology and Nutrition
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Bradford, William Dalton,
Professor of Pathology,
Pathology
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Choi, Steven Sok,
Associate Professor of Medicine,
Medicine, Gastroenterology
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Dinani, Amreen,
Associate Professor of Medicine,
Medicine, Gastroenterology
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Hirschey, Matthew,
Associate Professor of Medicine,
Cell Biology
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Nightingale, Kathryn Radabaugh,
Theo Pilkington Distinguished Professor of Biomedical Engineering,
Biomedical Engineering
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Pang, Herbert,
Adjunct Assistant Professor in the Department of Biostatistics & Bioinformatics,
Biostatistics & Bioinformatics
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White, Phillip James,
Assistant Professor in Medicine,
Pharmacology & Cancer Biology
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Yancy Jr., William Samuel,
Professor of Medicine,
Medicine, General Internal Medicine